BMC Endocrine Disorders via MedWorm.com

Assessment of quality of care given to diabetic patients at Jimma University Specialized Hospital Diabetes Follow-up clinic, Jimma, Ethiopia

BMC Endocrine Disorders — Tue, 20 Dec 2011 05:00:00 +0100

This study aims to describe the gaps in the care of Ethiopian diabetic patients at Jimma University Specialized Hospital. Methods: - A total of 329 diabetic patients were selected as participants in the study, aged 15 years or greater, who have been active in follow-up for their diabetes for more than 1 year at the hospital. They were interviewed for their demographic characters and relevant clinical profiles. Their charts were simultaneously reviewed for characters related to diabetes and related morbidities. Descriptive statistics was used for most variables and Chi-square test, where necessary, was used to test the association among various variables. P-value of < 0.05 was used as statistical significance. Results: - Blood glucose determination was done for 98.5% of patients at each of ...

Effect of 12 months of testosterone replacement therapy on metabolic syndrome components in hypogonadal men: data from the Testim Registry in the US (TRiUS)

BMC Endocrine Disorders — Tue, 01 Nov 2011 04:00:00 +0100

We examined the effect of 12 months of TRT on MetS components in a large cohort of hypogonadal men. Methods: Data were obtained from TRiUS (Testim(R) Registry in the United States), a 12-month, multicenter, prospective observational registry (N=849) of hypogonadal men prescribed Testim 1% testosterone gel (5-10 g/day). Data analyzed included age, total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), and MetS components: waist circumference, blood pressure, fasting blood glucose, plasma triglycerides, and HDL cholesterol. Results: Of evaluable patients (581/849) at baseline, 37% were MetS+ (n=213) and 63% were MetS- (n=368). MetS+ patients had significantly lower TT (p (Source: BMC Endocrine Disorders)

Reasons given by general practitioners for non-treatment decisions in younger and older patients with newly diagnosed type 2 diabetes mellitus in the United Kingdom: A survey study

BMC Endocrine Disorders — Fri, 28 Oct 2011 04:00:00 +0100

Background: Older patients with newly diagnosed type 2 diabetes mellitus are less likely to receive antihyperglycaemic therapy compared to their younger counterparts. The purpose of this study was to assess the reasons of general practitioners (GPs) for not treating younger and older patients with newly diagnosed type 2 diabetes mellitus with antihyperglycaemic agents. Methods: In a survey conducted between November 2009 and January 2010, 358 GPs from the United Kingdom selected reasons for not initiating antihyperglycaemic therapy in younger ( (Source: BMC Endocrine Disorders)

Association of Inflammation and Endothelial Dysfunction with Metabolic Syndrome, Prediabetes and Diabetes in Adults from Inner Mongolia, China

BMC Endocrine Disorders — Tue, 11 Oct 2011 04:00:00 +0100

Conclusions: Diabetes and the MetS are common in the Inner Mongolian population. Biomarkers of inflammation and endothelial dysfunction are associated with increased risk for prediabetes, diabetes and MetS in this population. These results are consistent with results from other populations. (Source: BMC Endocrine Disorders)

Impact of Severity, Duration, and Etiology of Hyperthyroidism on Bone Turnover Markers and Bone Mineral Density in Men

BMC Endocrine Disorders — Fri, 05 Aug 2011 23:00:00 +0100

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Impact of newly diagnosed abnormal glucose regulation on long-term prognosis in low risk patients with ST-elevation myocardial infarction: a follow-up study.

BMC Endocrine Disorders — Thu, 28 Jul 2011 23:00:00 +0100

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Circulating adiponectin levels are lower in Latino versus non-Latino white patients at risk for cardiovascular disease, independent of adiposity measures

BMC Endocrine Disorders — Wed, 06 Jul 2011 23:00:00 +0100

Background: Latinos in the United States have a higher prevalence of type 2 diabetes than non-Latino whites, even after controlling for adiposity. Decreased adiponectin is associated with insulin resistance and predicts T2DM, and therefore may mediate this ethnic difference. We compared total and high-molecular-weight (HMW) adiponectin in Latino versus white individuals, identified factors associated with adiponectin in each ethnic group, and measured the contribution of adiponectin to ethnic differences in insulin resistance. Methods: We utilized cross-sectional data from subjects in the Latinos Using Cardio Health Actions to reduce Risk study. Participants were Latino (n = 119) and non-Latino white (n = 60) men and women with hypertension and at least one other risk factor for CVD (age 6...

Efficacy of vitamin D3-fortified-yogurt drink on anthropometric, metabolic, inflammatory and oxidative stress biomarkers according to vitamin D receptor gene polymorphisms in subjects with type 2 diabetes: a study protocol for a randomized controlled clinical trial

BMC Endocrine Disorders — Tue, 21 Jun 2011 23:00:00 +0100

This study was designed to evaluate the possible role of VDR single nucleotide polymorphisms (SNPs) on different aspects of diabetic host response (anthropometric, metabolic, oxidative stress and inflammatory) to daily intake of vitamin D through fortified Persian yogurt drink (doogh) for 12 weeks. Methods: This study comprises two parts: (i) a case-control study; and (ii) an intervention trial. In the first part, VDR polymorphisms (Taq1, Fok1, apa1, Bsm1, and Cdx1) are determined in 350 T2DM patients and 350 non-diabetic subjects. In the second part, the possible effects of daily intake of two servings of vitamin D3-fortified yogurt drink (FYD; 500IU vitamin D/250mL) on some selected metabolic (including insulin resistance), inflammatory and oxidative stress biomarkers in 135 T2DM patient...

The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats

BMC Endocrine Disorders — Wed, 25 May 2011 23:00:00 +0100

Conclusions: The PPARalpha agonist fenofibrate, and to a lesser extent the PPARaplha agonist Wyeth 14643, maintained BMD and bone architecture at sham levels, while the PPARgamma agonist pioglitazone exaggerated bone loss and negatively affected bone architecture, in ovariectomized rats. (Source: BMC Endocrine Disorders)

Thyroid disease is a favorable prognostic factor in achieving sustained virologic response in chronic hepatitis C undergoing combination therapy: A nested case control study

BMC Endocrine Disorders — Mon, 23 May 2011 23:00:00 +0100

Conclusions: Development of TD during treatment for hepatitis C infection is associated with a significantly increased chance of achieving SVR. The pathophysiogical mechanisms for this observation remain to be determined.Trial RegistrationThe Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRB 12610000830099 (Source: BMC Endocrine Disorders)

Exenatide Once Weekly Treatment Maintained Improvements in Glycemic Control and Weight Loss Over 2 Years

BMC Endocrine Disorders — Thu, 28 Apr 2011 23:00:00 +0100

In this report, we describe the 2-year results of the open-label, open-ended extension to the DURATION-1 trial of exenatide QW for type 2 diabetes. Methods: A 2-stage protocol was used: patients received either exenatide QW (2 mg) or exenatide twice daily for 30 weeks (5 ug for the first 4 weeks and 10 ug thereafter), followed by 1.5 years of treatment with exenatide QW (2 mg), for a total of 2 years (104 weeks) of exenatide treatment. Of the 295 (intent-to-treat [ITT]) patients who entered the trial, 73% (n=216) completed 2 years of treatment (completer population). Baseline characteristics (mean +/-SE) for these patients were: A1C, 8.2 +/-0.1%; FPG, 168.4 +/-43.0 mg/dL; body weight, 101.1 +/-18.7 kg; and diabetes duration, 7 +/-5 years. Results: In the completer population, significant i...

Advanced Age, Altered Level of Consciousness and a New Diagnosis of Diabetes are Independently Associated with Hypernatreamia in Hyperglycaemic Crisis

BMC Endocrine Disorders — Sun, 17 Apr 2011 23:00:00 +0100

Background: There is limited literature on hypernatreamia in the setting of hyperglycaemic crisis. This is despite the fact that the presence of hypernatreamia may impact on the classification of hyperglycaemic crisis and its management particularly with regards to the nature of fluids therapy. We determined the prevalence of hypernatreamia and its associated factors at presentation for hyperglycaemic crisis. Methods: This was a retrospective review of data for hyperglycaemic crisis admissions in Nelson Mandela Academic Hospital, Mthatha, South Africa. The prevalence of hypernatreamia (uncorrected Serum Sodium at presentation > 145 mmol/L) was determined. Hyperosmolality was defined by calculated effective osmolality > 320 mosmols/Kg. Multivariate logistic regression was undertaken using v...

Delayed beta-cell response and glucose intolerance in young women with Turner syndrome

BMC Endocrine Disorders — Tue, 15 Mar 2011 00:00:00 +0100

Conclusions: Young normal weight TS women show significant glucose intolerance in spite of normal insulin secretion during hyperglycaemic clamping and normal insulin sensitivity. We recommend regularly testing for diabetes in TS.Registered with clinicaltrials.com, ID nr: NCT00419107 (Source: BMC Endocrine Disorders)

Ethnic disparity in 21-hydroxylase gene mutations identified in Pakistani congenital adrenal hyperplasia patients

BMC Endocrine Disorders — Fri, 18 Feb 2011 00:00:00 +0100

Conclusion: Our study showed that CAH exists in our population with ethnic difference in the prevalence of mutations examined. (Source: BMC Endocrine Disorders)

Treatment adherence with the easypodTM growth hormone electronic auto-injector and patient acceptance: survey results from 824 children and their parents

BMC Endocrine Disorders — Fri, 04 Feb 2011 00:00:00 +0100

Conclusions: easypodTM provides an accurate method of monitoring adherence to treatment with r-hGH. In children who received treatment with r-hGH using easypodTM, short-term adherence is good, and significantly higher in treatment-naive children compared with treatment-experienced children. Children/parents rate the device highly. The high level of acceptability of the device is reflected by a desire to continue using it by over 90% of the children in the survey. (Source: BMC Endocrine Disorders)

Glucose challenge increases circulating progenitor cells in Asian Indian male subjects with normal glucose tolerance which is compromised in subjects with pre-diabetes: A pilot study.

BMC Endocrine Disorders — Tue, 11 Jan 2011 00:00:00 +0100

Background: Haematopoietic stem cells undergo mobilization from bone marrow to blood in response to physiological stimuli such as ischemia and tissue injury. The aim of study was to determine the kinetics of circulating CD34+ and CD133+CD34+ progenitor cells in response to 75g glucose load in subjects with normal and impaired glucose metabolism. Methods: Asian Indian male subjects (n=50) with no prior history of glucose imbalance were subjected to 2 hour oral glucose tolerance test (OGTT). 24 subjects had normal glucose tolerance (NGT), 17 subjects had impaired glucose tolerance (IGT) and 9 had impaired fasting glucose (IFG). The IGT and IFG subjects were grouped together as pre-diabetes group (n=26). Progenitor cell counts in peripheral circulation at fasting and 2 hour post glucose chall...

Systematic review of communication technologies to promote access and engagement of young people with diabetes into healthcare

BMC Endocrine Disorders — Thu, 06 Jan 2011 00:00:00 +0100

Conclusions: The breadth of study design and types of technologies reported make the magnitude of benefit and their effects on health difficult to determine. While communication technologies may increase the frequency of contact between patient and health care professional, it remains unclear whether this results in improved outcomes and is often the basis of the intervention itself. Further research is needed to explore the effectiveness and cost effectiveness of increasing the use of communication technologies between young people and healthcare professionals. (Source: BMC Endocrine Disorders)

Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross-sectional study

BMC Endocrine Disorders — Thu, 16 Dec 2010 00:00:00 +0100

Conclusions: Negative associations of age with random insulin levels, together with positive associations of age with proinsulin and proinsulin/insulin, point towards a loss of beta cell function inherent in the ageing process. (Source: BMC Endocrine Disorders)

Glucagon-like peptide analogues for type 2 diabetes mellitus: systematic review and meta-analysis

BMC Endocrine Disorders — Thu, 09 Dec 2010 00:00:00 +0100

Conclusions: GLP-1 agonists are effective in improving glycaemic control and promoting weight loss. (Source: BMC Endocrine Disorders)

Symptomatic Hypopituitarism revealing primary suprasellar lymphoma.

BMC Endocrine Disorders — Mon, 29 Nov 2010 00:00:00 +0100

Conclusion: This case presentation reports a rare cause of hypopituitarism. Primary suprasellar lymphoma is extremely rare and represented a real diagnostic challenge. Besides, suprasellar masses are varied in aetiology and can present diagnostic problems for a radiologist. Also, because of the increased incidence of PCNSL, lymphoma must be kept in mind in the differential diagnosis of lesions in the suprasellar region.Key words:Hypopituitarism, suprasellar mass, primary central nervous system lymphoma. (Source: BMC Endocrine Disorders)

Short term effects of a low-carbohydrate diet in overweight and obese subjects with low HDL-C levels

BMC Endocrine Disorders — Tue, 09 Nov 2010 00:00:00 +0100

Background: The aim of this study was to evaluate short-term effects of a low-carbohydrate diet in overweight and obese subjects with low HDL-C levels. Methods: Overweight (BMI between 25-30 kg/m2) or obese (BMI over 30 kg/m2) subjects with low HDL-C levels (men with HDL-C (Source: BMC Endocrine Disorders)

Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies - Results from The Hvidoere Study Group

BMC Endocrine Disorders — Wed, 22 Sep 2010 23:00:00 +0100

Conclusion: GAD, IA-2A, and ICA negative children with new onset type 1 diabetes have slower disease progression as assessed by residual beta-cell function and improved glycemic control 12 months after diagnosis. One out of 24 had a mutation in ABCC8, suggesting that screening of ABCC8 should be considered in patients with idiopathic diabetes. (Source: BMC Endocrine Disorders)

Diabetes: cost of illness in Norway

BMC Endocrine Disorders — Sun, 19 Sep 2010 23:00:00 +0100

Conclusions: Diabetes represents a considerable burden to society in terms of health care costs and productivity losses. (Source: BMC Endocrine Disorders)

Predictors of mortality of patients newly diagnosed with clinical type 2 diabetes: a 5-year follow up study

BMC Endocrine Disorders — Mon, 09 Aug 2010 23:00:00 +0100

Conclusions: We found that patients who rated their health as less than excellent had increased 5-year mortality, similar to that of patients with prevalent CVD, even when biochemical, clinical and life-style variables were controlled for. This finding could motivate doctors to discuss perceptions of health with newly diagnosed diabetic patients and be attentive to patients with suboptimal health ratings. Our findings also confirm that life-style changes and optimizing treatment are particularly relevant for relatively young and inactive patients and those who already have CVD or (micro)albuminuria at the time of diabetes diagnosis. (Source: BMC Endocrine Disorders)

Whether to report diabetes as the underlying cause-of-death? a survey of internists of different sub-specialties

BMC Endocrine Disorders — Thu, 22 Jul 2010 23:00:00 +0100

Conclusions: Internists of different sub-specialties do have different opinions on the reporting of diabetes as the UCD, especially when the diabetic patient has a coexisting CVD. (Source: BMC Endocrine Disorders)

Increases in summer serum 25-hydroxyvitamin D (25OHD) concentrations in elderly subjects in Sao Paulo, Brazil vary with age, gender and ethnicity

BMC Endocrine Disorders — Sun, 13 Jun 2010 23:00:00 +0100

Background: Hypovitaminosis D is a common condition among elderly individuals in temperate-climate countries, with a clear seasonal variation on 25 hydroxyvitamin D levels, increasing after summer and decreasing after winter, but there are few data from sunny countries such as Brazil. Many factors can interfere on vitamin D cutaneous synthesis. We aimed at studying the 25OHD variations during winter and summer in an outdoor physically active elderly population living in Sao Paulo city, and analysed their determining factors. Methods: Ninety-nine individuals (52 women and 47 men, from 55 to 83 years old) from different ethnic groups were selected from an outdoor physical activity group. Data are reported as Mean +/- SD, and we used Pearson Linear Correlation, Student's t-test for non-relate...

Is impaired energy regulation the core of the metabolic syndrome in various ethnic groups of the USA and Taiwan?

BMC Endocrine Disorders — Mon, 31 May 2010 23:00:00 +0100

Conclusions: There is a MetS core which unifies populations. It comprises WC, TG and FPG as a core, IER, which may be expressed and modulated in various second order ways. (Source: BMC Endocrine Disorders)

The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study

BMC Endocrine Disorders — Sun, 16 May 2010 23:00:00 +0100

Conclusions: TCF7L2 rs7903146 is not consistently associated with retinal microvascular signs. However, we report an association between the TCF7L2 rs7903146 polymorphism and focal arteriolar narrowing in Caucasians with hypertension or without diabetes. Further research in other large, population-based studies is needed to replicate these findings. (Source: BMC Endocrine Disorders)

Prolactinomas, Cushing's disease and acromegaly: debating the role of medical therapy for secretory pituitary adenomas

BMC Endocrine Disorders — Sun, 16 May 2010 23:00:00 +0100

In conclusion, the treatment of patients with pituitary adenomas requires a multidisciplinary approach. Dopamine agonists are an effective first-line medical therapy in most patients with a prolactinoma, and somatostatin analogues can be used as first-line therapy in selected patients with acromegaly. Current medical therapies for Cushing's disease primarily focus on adrenal blockade of cortisol production, although pasireotide and cabergoline show promise as pituitary-directed medical therapy for Cushing's disease; further long-term evaluation of efficacy and safety is important. (Source: BMC Endocrine Disorders)

Thyroid function derangement and childhood obesity: an Italian experience

BMC Endocrine Disorders — Mon, 03 May 2010 23:00:00 +0100

Conclusions: These results suggest that: (1) a moderate elevation of TSH concentrations, is frequently found in obese children; (2) in obese children increase of TSH is not associated to metabolic risk factors, (3) hyperthyrotropinemia is reversible after weight loss and these data suggest that it should not be treated. (Source: BMC Endocrine Disorders)

Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes

BMC Endocrine Disorders — Wed, 21 Apr 2010 23:00:00 +0100

Conclusions: In this updated pooled safety analysis of data from 10,246 patients with type 2 diabetes, sitagliptin 100 mg/day was generally well tolerated in clinical trials of up to 2 years in duration. (Source: BMC Endocrine Disorders)

Low serum creatinine is associated with type 2 diabetes in morbidly obese women and men: a cross-sectional study

BMC Endocrine Disorders — Sat, 17 Apr 2010 23:00:00 +0100

Conclusions: Low serum creatinine is a predictor of type 2 diabetes in Caucasian morbidly obese patients, independent of age, gender, family history of diabetes, anthropometric measures, hypertension, and current smoking. Longitudinal studies of both obese and non-obese populations are needed to investigate whether serum creatinine may be causally linked with type 2 diabetes, and if so, precisely how they are linked. (Source: BMC Endocrine Disorders)

Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control

BMC Endocrine Disorders — Tue, 06 Apr 2010 23:00:00 +0100

Conclusions: There was EPC dysfunction in type 2 diabetes which might be improved by strict glycemic control. However, the circulating EPC number and proliferative function in patients with good glycemic control did not reach the level in healthy controls. (Source: BMC Endocrine Disorders)

Early limited nitrosamine exposures exacerbate high fat diet-mediated type2 diabetes and neurodegeneration

BMC Endocrine Disorders — Fri, 19 Mar 2010 00:00:00 +0100

Conclusions: Early limited exposure to nitrosamines exacerbates the adverse effects of later chronic high dietary fat intake in promoting T2DM and neurodegeneration. The mechanism involves increased generation of ceramides and probably other toxic lipids in brain. (Source: BMC Endocrine Disorders)

The weight lowering effect of sibutramine and its impact on serum lipids in cardiovascular high risk patients with and without type 2 diabetes mellitus - an analysis from the SCOUT lead-in period

BMC Endocrine Disorders — Fri, 26 Feb 2010 00:00:00 +0100

We examined whether blood lipid changes with short term administration of the weight lowering drug, sibutramine and lifestyle modification in obese and overweight high-risk patients was associated with T2D status at screening. Methods: The Sibutramine Cardiovascular OUTcomes (SCOUT) trial included obese and overweight patients at increased risk of cardiovascular events. All patients received guidance on diet and exercise plus once-daily 10mg sibutramine during the 6-week, single blind lead-in period. Multivariable regression models were used to investigate factors associated with changes in lipid levels during the first four weeks of treatment. Results: A total of 10 742 patients received at least one dose of sibutramine during the 6-week lead-in period of SCOUT. After four weeks, patients...

Hypothyroidism among military infants born in countries of varied iodine nutrition status

BMC Endocrine Disorders — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions: In this study, hypothyroidism in military-dependent infants did not vary by birth location, but was associated with other risk factors, including preterm birth, civilian maternal status, and advanced maternal age. (Source: BMC Endocrine Disorders)

Role of Receptor-Interacting Protein 140 in human fat cells

BMC Endocrine Disorders — Fri, 29 Jan 2010 00:00:00 +0100

Conclusions: Human RIP140 inhibits glucose uptake and the expression of genes promoting energy expenditure in the same fashion as the murine orthologue. Increased levels of human RIP140 in subcutaneous WAT of lean subjects may contribute to economize on energy stores. By contrast, the function and expression pattern does not support that RIP140 regulate human obesity. (Source: BMC Endocrine Disorders)

Endogenous melatonin and oxidatively damaged guanine in DNA

BMC Endocrine Disorders — Sat, 17 Oct 2009 23:00:00 +0100

Background: A significant body of literature indicates that melatonin, a hormone primarily produced nocturnally by the pineal gland, is an important scavenger of hydroxyl radicals and other reactive oxygen species. Melatonin may also lower the rate of DNA base damage resulting from hydroxyl radical attack and increase the rate of repair of that damage. This paper reports the results of a study relating the level of overnight melatonin production to the overnight excretion of the two primary urinary metabolites of the repair of oxidatively damaged guanine in DNA. Methods: Mother-father-daughter(s) families (n=55) were recruited and provided complete overnight urine samples. Total overnight creatinine-adjusted 6-sulphatoxymelatonin (aMT6s/Cr) has been shown to be highly correlated with total...

Age-related increases in parathyroid hormone may be antecedent to both osteoporosis and dementia

BMC Endocrine Disorders — Mon, 12 Oct 2009 23:00:00 +0100

Conclusion: Our findings of a statistically lower bone density and prolonged P300 in patients with high parathyroid hormone levels may suggest that increased parathyroid hormone levels coupled with prolonged P300 latency may become putative biological markers of both dementia and osteoporosis and warrant intensive investigation. (Source: BMC Endocrine Disorders)

Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluation

BMC Endocrine Disorders — Wed, 07 Oct 2009 23:00:00 +0100

Conclusions: PEG is highly effective for improving patients' IGF-1 level. Signs and symptoms of disease improve but evidence is lacking about long term effects on improved signs and symptoms of disease, quality of life, patient compliance and safety. Economic evaluation indicated that if current standards (UK) for determining cost-effectiveness of therapies were to be applied to PEG it would be considered not to represent good value for money. (Source: BMC Endocrine Disorders)

The consequences of delaying insulin initiation in UK type 2 diabetes patients failing oral hyperglycaemic agents: a modelling study

BMC Endocrine Disorders — Sun, 04 Oct 2009 23:00:00 +0100

Conclusions: UK type 2 diabetes patients are at increased risk of a large number of diabetes-related complications due to an unnecessary delay in insulin initiation. Despite clear guidelines recommending tight glycaemic control this failure to begin insulin therapy promptly is likely to result in needlessly reduced life expectancy and compromised quality of life. (Source: BMC Endocrine Disorders)

The association between history of diabetic foot ulcer, perceived health and psychological distress: the Nord-Trondelag Health Study

BMC Endocrine Disorders — Mon, 24 Aug 2009 23:00:00 +0100

Conclusions: Perceived health and psychological well-being were significantly poorer among participants with diabetes and a history of foot ulcer compared to those without diabetes. Among people with diabetes, a history of foot ulcer had significant negative impact on perceived health but did not independently contribute to psychological distress. (Source: BMC Endocrine Disorders)

Actos Now for the Prevention of Diabetes (ACT NOW) Study

BMC Endocrine Disorders — Tue, 28 Jul 2009 23:00:00 +0100

Conclusion: ACT NOW is designed to determine if pioglitazone can prevent/delay progression to diabetes in high risk IGT subjects, and to define the mechanisms (improved insulin sensitivity and/or enhanced beta cell function) via which pioglitazone exerts its beneficial effect on glucose metabolism to prevent/delay onset of T2DM.Trial Registration: clinical trials.gov identifier: NCT00220961 (Source: BMC Endocrine Disorders)

Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study

BMC Endocrine Disorders — Sat, 20 Jun 2009 23:00:00 +0100

Background: Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population. Methods: In 2001-2004, 1811 men and women (30-75 years) were randomly selected from the Vara population, south-western Sweden (81% participation rate). Of these, 1671 subjects with full information on basal morning and evening salivary cortisol and anthropometric measurements were included in this cross-sectional study. Differences between groups were examined by general linear model and by logistic and linear regression analyses. Results: Morning and delta-cortisol (morning - evening cortisol) were significantly higher in women than men. In both genders ...

Randomised controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial

BMC Endocrine Disorders — Thu, 18 Jun 2009 23:00:00 +0100

DiscussionGiven the extensive phenotypic characterization, this study will provide valuable insights into the mechanisms underlying the beneficial effects of aerobic exercise as well as the efficacy, feasibility and safety of such interventions in this age group. (Source: BMC Endocrine Disorders)

Cost-effectiveness comparison between palpation- and ultrasound-guided thyroid fine-needle aspiration biopsies

BMC Endocrine Disorders — Sat, 16 May 2009 04:00:00 +0100

Conclusions: Universal application of USG-FNA for all thyroid nodules is cost-effective and saves 138 Euros per additional accurate diagnosis of benign versus malignant thyroid nodular disease. Trial registration: ClinicalTrials.gov, NCT00571090 (Source: BMC Endocrine Disorders)

DreamTel; Diabetes risk evaluation and management tele-monitoring study

BMC Endocrine Disorders — Sat, 09 May 2009 04:00:00 +0100

DiscussionThe first phase will determine if the use of the Bluetooth enabled blood glucose devices which can transmit results electronically will lead to changes in A1c levels. It will also determine the feasibility of recruiting subjects to use this technology. In the second and third phases lasting 18 months, the Diabetes Risk Evaluation and Management Tele-monitoring (DreamTel) study will determine if the delivery of a diabetes intensification management program by the Home Care team supported by the Bluetooth enabled glucose meters leads to improvements in diabetes management. Protocol NCT00325624 (Source: BMC Endocrine Disorders)

Family history of diabetes and clinical characteristics in Greek subjects with type 2 diabetes

BMC Endocrine Disorders — Mon, 27 Apr 2009 04:00:00 +0100

Conclusion: The present study showed an excess maternal transmission of T2D in a sample of Greek diabetic patients. However, no different influence was found between maternal and paternal diabetes on the clinical characteristics of diabetic patients except for LDL-cholesterol levels and presence of hypertension. The presence of a family history of diabetes resulted to an early onset of the disease to the offspring. (Source: BMC Endocrine Disorders)

Graz Endocrine Causes Of Hypertension (GECOH) study: a diagnostic accuracy study of aldosterone to active renin ratio in screening for primary aldosteronism

BMC Endocrine Disorders — Tue, 07 Apr 2009 04:00:00 +0100

Conclusions: Screening for PA with subsequent targeted treatment is of great potential benefit for hypertensive patients. In the GECOH study we will evaluate a standardised procedure for screening and diagnosing of this disease. (Source: BMC Endocrine Disorders)

Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPAR gamma agonist pioglitazone

BMC Endocrine Disorders — Mon, 30 Mar 2009 04:00:00 +0100

Conclusions: We show opposite skeletal effects of PPAR alpha and gamma agonists in intact female rats. FENO resulted in significantly higher femoral BMD and lower medullary area, while PIO induced bone loss and impairment of the mechanical strength. This represents a novel skeletal effect of PPAR alpha activation. (Source: BMC Endocrine Disorders)

Clinical features, predictive factors and outcome of hyperglycaemic emergencies in a developing country

BMC Endocrine Disorders — Tue, 10 Mar 2009 04:00:00 +0100

Conclusion: HHS carry a higher case fatality rate than DKA and the predictive factors for hyperglycaemic emergencies' mortality in the Nigerian with DM include foot ulcers, hypokalaemia and being elderly. (Source: BMC Endocrine Disorders)

Clinical features,predictive factors and outcome of hyperglycaemic emergencies in a developing country.

BMC Endocrine Disorders — Tue, 10 Mar 2009 04:00:00 +0100

Conclusions: HHS carry a higher case fatality rate than DKA and the predictive factors for hyperglycaemic emergencies' mortality in the Nigerian with DM include foot ulcers, hypokalaemia and being elderly. (Source: BMC Endocrine Disorders)

Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFκB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus

BMC Endocrine Disorders — Wed, 25 Feb 2009 05:00:00 +0100

Conclusion: In type 2 diabetic patients, the anti-inflammatory effect of rosiglitazone is not reflected by changes in NFκB and PPARγ target genes in PBMCs in vivo. Furthermore, our results do not support that high insulin concentrations contribute to the pro-inflammatory profile in type 2 diabetic patients. (Source: BMC Endocrine Disorders)

Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?

BMC Endocrine Disorders — Wed, 25 Feb 2009 05:00:00 +0100

Conclusions: In summary, the zinc transporting system in beta-cells is influenced by the exposure to cytokines. Particularly ZnT8, which has been associated with the development of diabetes, seems to be cytokine sensitive. (Source: BMC Endocrine Disorders)

Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFkappaB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus

BMC Endocrine Disorders — Wed, 25 Feb 2009 05:00:00 +0100

Background Rosiglitazone not only improves insulin-sensitivity, but also exerts anti-inflammatory effects. We have now examined in type 2 diabetic patients if these effects are reflected by changes in mRNA expression in peripheral blood mononuclear cells (PBMCs) to see if these cells can be used to study these anti-inflammatory effects at the molecular level in vivo. Method Eleven obese type 2 diabetic patients received rosiglitazone (2x4 mg/d) for 8 weeks. Fasting blood samples were obtained before and after treatment. Ten obese control subjects served as reference group. The expression of NFkappaB-related genes and PPARgamma target genes in PBMCs, plasma TNFalpha, IL6, MCP1 and hsCRP concentrations were measured. In addition, blood samples were obtained after a hyperinsulinemic-euglycem...

Self-care coping strategies in people with diabetes: a qualitative exploratory study

BMC Endocrine Disorders — Fri, 20 Feb 2009 05:00:00 +0100

Conclusions: Patients have different diabetes self-care coping strategies which are influenced by their self-care health value and consequently may affect their diet and exercise choices, frequency of blood glucose monitoring, and compliance with prescribed medication regimens. Particular attention should be paid to the patient's self-care coping strategy, and self-care protocols should be tailored to complement the different "ideal" patient types. (Source: BMC Endocrine Disorders)

Diabetes Mellitus: Indigenous naming, indigenous diagnosis and self-management in an African setting: the example from Cameroon

BMC Endocrine Disorders — Thu, 19 Feb 2009 05:00:00 +0100

Conclusion: The evolution of indigenous names for diabetes is an important factor that influences the subsequent self-diagnosis and management of diabetes in both biomedical and traditional health care settings.KeywordsIndigenous naming, diagnosis, self-monitoring, diabetes mellitus, Africa. (Source: BMC Endocrine Disorders)

Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

BMC Endocrine Disorders — Wed, 28 Jan 2009 05:00:00 +0100

Conclusion: The efficacy of a high intensity exercise protocol, involving only ~250 kcal of work each week, to substantially improve insulin action in young sedentary subjects is remarkable. This novel time-efficient training paradigm can be used as a strategy to reduce metabolic risk factors in young and middle aged sedentary populations who otherwise would not adhere to time consuming traditional aerobic exercise regimes. (Source: BMC Endocrine Disorders)

Cardiovascular autonomic function tests in an African population

BMC Endocrine Disorders — Tue, 30 Dec 2008 05:00:00 +0100

Conclusions: The test battery revealed cut-off values different from those measured in Caucasians. Further studies are recommended to assess whether these reference values are generally applicable to Africans. (Source: BMC Endocrine Disorders)

The Edinburgh Type 2 Diabetes Study: study protocol

BMC Endocrine Disorders — Thu, 11 Dec 2008 05:00:00 +0100

This study will provide a wealth of epidemiological and biomarker data that should be invaluable in the identification of potentially modifiable, causal risk factors for diabetes-related cognitive impairment, liver dysfunction and vascular disease, which can be targeted for the development of preventive and therapeutic interventions. (Source: BMC Endocrine Disorders)

Association of angiotensin-converting enzyme inhibitor therapy and comorbidity in diabetes: results from the Vermont Diabetes Information System

BMC Endocrine Disorders — Fri, 05 Dec 2008 05:00:00 +0100

Conclusions: ACE inhibitor use is associated with a lower likelihood of a history of cancer and peptic ulcers in patients with diabetes. These findings are limited by the cross sectional study design, self-report of comorbid diagnoses, and lack of information on the timing and duration of ACE inhibitor use. Further research is needed to confirm these associations and understand their mechanisms. (Source: BMC Endocrine Disorders)

Pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective study

BMC Endocrine Disorders — Thu, 27 Nov 2008 05:00:00 +0100

Conclusions: Our results corroborate those of previous studies showing that thyroid hormone levels change markedly during childhood, and that adult reference intervals are not universally applicable to children. Moreover, differences of our reference intervals compared to previous studies were observed, likely caused by different antibody characteristics of various analytical methods, different populations or undefined geographic covariates, e.g. iodine and selenium status. (Source: BMC Endocrine Disorders)

The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome

BMC Endocrine Disorders — Mon, 13 Oct 2008 04:00:00 +0100

Background: Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is caused by artefacts, is a form of beneficial adaptation, or is a disorder requiring treatment. Trials investigating substitution therapy of NTIS revealed contradictory results. The comparison of heterogeneous patient cohorts may be the cause for those inconsistencies.ObjectivesPrimary objective of this study is the identification and differentiation of different functional states of thyrotropic feedback control in order to define relevant evaluation criteria for the prognosis of ...

The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome.

BMC Endocrine Disorders — Mon, 13 Oct 2008 04:00:00 +0100

Background: Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is caused by artefacts, is a form of beneficial adaptation, or is a disorder requiring treatment. Trials investigating substitution therapy of NTIS revealed contradictory results. The comparison of heterogeneous patient cohorts may be the cause for those inconsistencies. Objectives: Primary objective of this study is the identification and differentiation of different functional states of thyrotropic feedback control in order to define relevant evaluation criteria for the prognosis ...

Randomized, controlled, parallel-group prospective study to investigate the clinical effectiveness of early insulin treatment in patients with latent autoimmune diabetes in adults

BMC Endocrine Disorders — Thu, 24 Jul 2008 04:00:00 +0100

This study seeks the best treatment for early LADA in terms of maintaining glycaemic control and maintaining natural insulin production.Trial registrationISRCTN63815121 (Source: BMC Endocrine Disorders)

Randomized, controlled, parallel-group prospective study to investigate the clinical effectiveness of early insulin treatment in patients with latent autoimmune diabetes in adults.

BMC Endocrine Disorders — Thu, 24 Jul 2008 04:00:00 +0100

This study seeks the best treatment for early LADA in terms of maintaining glycaemic control and maintaining natural insulin production. (Source: BMC Endocrine Disorders)

Primary prevention of diabetes mellitus type 2 and cardiovascular diseases using a cognitive behavior program aimed at lifestyle changes in people at risk: design of a randomized controlled trial

BMC Endocrine Disorders — Tue, 24 Jun 2008 04:00:00 +0100

DiscussionChanging behaviors is difficult, requires time, considerable effort and motivation. Combining the two counseling methods MI and PST, followed by booster sessions may result in sustained behavioral change. Trial registration: Current Controlled Trials ISRCTN59358434 (Source: BMC Endocrine Disorders)

Validation of ICD-9-CM coding algorithm for improved identification of hypoglycemia visits

BMC Endocrine Disorders — Tue, 01 Apr 2008 04:00:00 +0100

Conclusions: The proposed algorithm improves on prior strategies to identify hypoglycemia visits in administrative data sets and will enhance the ability to study the epidemiology and design interventions for this important complication of diabetes care. (Source: BMC Endocrine Disorders)

Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance

BMC Endocrine Disorders — Thu, 27 Mar 2008 04:00:00 +0100

Conclusions: The 2-year intervention up-regulated mitochondrial HSP expressions in middle-aged subjects with impaired glucose tolerance. These improvements, however, were not correlated directly with enhanced glucose tolerance. (Source: BMC Endocrine Disorders)

The role of Se, vitamin C, and zinc in benign thyroid diseases and of Se in malignant thyroid diseases: low Se levels are found in subacute and silent thyroiditis and in papillary and follicular carcinoma

BMC Endocrine Disorders — Fri, 25 Jan 2008 05:00:00 +0100

Conclusions: The Ho can be accepted for zinc levels whereas it has to be rejected for Se. Patients with benign or malignant thyroid diseases can present low Se levels as compared to controls. Low levels of vitamin C were found in some subgroups of patients. (Source: BMC Endocrine Disorders)

Study protocol: Insulin and its role in cancer

BMC Endocrine Disorders — Mon, 22 Oct 2007 04:00:00 +0100

This study could provide insights to the role of insulin, insulin resistance, IGF-1 in carcinogenesis although a precise role and the extent of influence cannot be determined. In future, cancer prevention and treatment strategies could revolve around insulin and insulin resistance. (Source: BMC Endocrine Disorders)

Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas

BMC Endocrine Disorders — Thu, 04 Oct 2007 04:00:00 +0100

Conclusions: Features of the somatic mutations suggest that they may confer a selective advantage and contribute to the molecular pathogenesis of parathyroid adenomas. Importantly, the statistically significant differences in mutation prevalence in oxyphil vs. chief cell adenomas also suggest that mtDNA mutations may contribute to the oxyphil phenotype. (Source: BMC Endocrine Disorders)

Association between erythrocyte Na+K+-ATPase activity and some blood lipids in Type 1 diabetic patients from Lagos, Nigeria

BMC Endocrine Disorders — Mon, 01 Oct 2007 04:00:00 +0100

Conclusion: It can be concluded that poor glycemic control evokes greater reduction in erythrocyte Na+K+-ATPase activity and promote enzyme-blood atherogenic lipid relationships in Type 1 diabetic Nigerian patients. (Source: BMC Endocrine Disorders)

Brief Intervention in Type 1 diabetes - Education for Self-efficacy (BITES): Protocol for a randomised controlled trial to assess biophysical and psychological effectiveness

BMC Endocrine Disorders — Fri, 14 Sep 2007 04:00:00 +0100

DiscussionWe hope the trial will demonstrate feasibility of a pragmatic randomised trial of BITES and help quantify therapeutic effect. A follow up multi-centre trial powered to detect this effect could provide further evidence. Trial registration: Current Controlled Trials ISRCTN75807800 (Source: BMC Endocrine Disorders)

Is annual surveillance of all treated hypothyroid patients necessary?

BMC Endocrine Disorders — Mon, 02 Jul 2007 04:00:00 +0100

Conclusions: 18 monthly surveillance may be adequate in the long term follow-up of hypothyroid patients less than 60 years of age on a stable thyroxine dose of 100-150 micrograms/day where there are robust follow-up mechanisms in place. Implementing this strategy has potential for cost saving. (Source: BMC Endocrine Disorders)

A randomized, double-blind, placebo-controlled trial to assess safety and tolerability during treatment of type 2 diabetes with usual diabetes therapy and either Cycloset or placebo

BMC Endocrine Disorders — Mon, 25 Jun 2007 04:00:00 +0100

This study will extend the current data on Cycloset safety, tolerability and efficacy in individuals with type 2 diabetes to include its effects in combination with thiazolodinediones, insulin secretagogues, metformin, alpha-glucosidase inhibitors and exogenous insulin regimens. Trial registration: clinical trials.gov NCT00377676 (Source: BMC Endocrine Disorders)

Accuracy of self-reported height measurements in parents and its effect on mid-parental target height calculation

BMC Endocrine Disorders — Mon, 02 Apr 2007 04:00:00 +0100

Background: Clinical determination of mid-parental height is an important part of the assessment of a child's growth, however our clinical impression has been that parents cannot be relied upon to accurately report their own heights. Therefore, we conducted this study to assess the accuracy of parental height self-reporting and its effect on calculated mid-parental target height for children presenting to a pediatric endocrinology office. Methods: All parents bringing their children for an initial evaluation to a pediatric endocrinology clinic over a period of nine months were questioned and then measured by a pediatric endocrinologist. Parents were blinded to the study. Mid-parental target heights, based on reported and actual height were compared. Results: There were 241 families: 98 fa...

The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study

BMC Endocrine Disorders — Fri, 30 Mar 2007 04:00:00 +0100

Conclusions: This study suggests a functional variant of UCP1 contributes to the variance of AIRg in an AA population; the plausibility of this unexpected association is supported by the novel finding that UCP1 is expressed in islets. (Source: BMC Endocrine Disorders)

A multinodular goiter as the initial presentation of a renal cell carcinoma harbouring a novel VHL mutation

BMC Endocrine Disorders — Thu, 26 Oct 2006 06:00:00 +0100

Conclusion: In the presence of a clear-cell tumor of the thyroid gland, screening for somatic mutations in the VHL gene in material derived from thyroid aspirates might provide additional information to immunocytochemical studies and therefore plays a contributory role to establish the final diagnosis. Moreover, in a near future, this piece of information might be useful to define a targeted therapy. (Source: BMC Endocrine Disorders)

Insulin versus oral agents in the management of Cystic Fibrosis Related Diabetes: a case based study

BMC Endocrine Disorders — Wed, 21 Jun 2006 06:00:00 +0100

Conclusions: Insulin alone may not be the only therapeutic option in managing CFRD. Oral hypoglycemic agents were equally effective in treating CFRD and may provide an alternative class of agents for patients reluctant in using insulin. (Source: BMC Endocrine Disorders)

Reversible hypothyroidism and Whipple's disease

BMC Endocrine Disorders — Wed, 10 May 2006 06:00:00 +0100

Conclusion: This is the first ante-mortem case report studying the possible involvement of the thyroid gland by Whipples disease. Despite the normalization of her thyroid function test biochemically after antibiotic therapy, there is diminished thyroid reserve thus requiring close and regular monitoring. (Source: BMC Endocrine Disorders)

Neurocognitive function in children with compensated hypothyroidism: lack of short term effects on or off thyroxin

BMC Endocrine Disorders — Mon, 20 Mar 2006 07:00:00 +0100

Conclusion: In this small, short term study, thyroxin therapy could not be shown to affect neuropsychological function in children with compensated hypothyroidism. These children may have attention problems but appear to have normal verbal and visual processing, motor speed/coordination and achievement. (Source: BMC Endocrine Disorders)

Echocardiographic assessment of subclinical left ventricular eccentric hypertrophy in adult-onset GHD patients by geometric remodeling: an observational case-control study

BMC Endocrine Disorders — Tue, 28 Feb 2006 07:00:00 +0100

Conclusions: Though the lack of significant differences in resting LV morphology and function, about 25% of GHD patients in this study showed high LVMi (as eccentric LV hypertrophy), not dissimilarly to overweight controls. This finding, which prognostic role is already known in obese and hypertensive patients, is worthy to be investigated in GHD patients through wider controlled trials. (Source: BMC Endocrine Disorders)

Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance?

BMC Endocrine Disorders — Sat, 10 Dec 2005 07:00:00 +0100

Background: The global pattern of varying prevalence of diseases of affluence, such as obesity, cardiovascular disease and diabetes, suggests that some environmental factor specific to agrarian societies could initiate these diseases.Presentation of the hypothesisWe propose that a cereal-based diet could be such an environmental factor. Through previous studies in archaeology and molecular evolution we conclude that humans and the human leptin system are not specifically adapted to a cereal-based diet, and that leptin resistance associated with diseases of affluence could be a sign of insufficient adaptation to such a diet. We further propose lectins as a cereal constituent with sufficient properties to cause leptin resistance, either through effects on metabolism central to the proper fun...

Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice

BMC Endocrine Disorders — Thu, 08 Dec 2005 07:00:00 +0100

Conclusion: Islets from diabetic mice show some mis-regulation of intracellular pH, and their secretory capacity is consistently enhanced by DMA/amiloride. Thus, amiloride derivatives show promise as potential therapeutic agents for type 2 diabetes. (Source: BMC Endocrine Disorders)

The spectrum of thyroid dysfunction in an Australian hepatitis C population treated with combination Interferon-α2β and Ribavirin

BMC Endocrine Disorders — Wed, 12 Oct 2005 06:00:00 +0100

Conclusion: Ninety three percent of HCV treated patients have intact thyroid function at the end of treatment. The predominant TD is hypothyroidism. The predominant pattern of thyrotoxicosis (TTX) is that of thyroiditis although the number is small. Graves' like disease was not observed. People with pre-existing thyroid auto-antibodies should be closely monitored for thyroid dysfunction, particularly hypothyroidism. (Source: BMC Endocrine Disorders)

Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study

BMC Endocrine Disorders — Fri, 01 Jul 2005 06:00:00 +0100

Conclusion: CETP TaqI B and APOE HhaI polymorphism may not be associated with type II diabetes mellitus in North Indian population, however CETP TaqI B polymorphism may be associated with hypertension along with T2DM. (Source: BMC Endocrine Disorders)

Insulin resistance in adolescents with Down syndrome: a cross-sectional study

BMC Endocrine Disorders — Fri, 17 Jun 2005 06:00:00 +0100

Conclusion: The obese and overweight, female and adult patients showed the highest values of HOMA and insulin. (Source: BMC Endocrine Disorders)

An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36

BMC Endocrine Disorders — Wed, 01 Jun 2005 06:00:00 +0100

Conclusion: The polymorphism in the promoter region of the IGF-I gene is related to birth weight in men only, and to LDL concentration only. Furthermore, the genotype for this polymorphism modified the relationships between birth weight and the risk factors, especially for systolic and diastolic blood pressure. (Source: BMC Endocrine Disorders)

Effects of aging and type 2 diabetes on resting and post occlusive hyperemia of the forearm; the impact of rosiglitazone

BMC Endocrine Disorders — Thu, 24 Mar 2005 07:00:00 +0100

Conclusion: These studies suggest a different mechanism causing a reduction in vascular reactivity with aging and diabetes. (Source: BMC Endocrine Disorders)