MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Neurology' source. Wed, 08 Feb 2012 20:42:58 +0100 http://www.medworm.com/index.php?rid=5668631&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F12%2F2 Conclusions: Donepezil is highly cost-effective in patients with AD in Germany, leading to improvements in health outcomes and substantial savings compared to no treatment. This holds across a variety of sensitivity analyses. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5668631 Wed, 08 Feb 2012 05:00:00 +0100 5668631 http://www.medworm.com/index.php?rid=5668630&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F12%2F3 This study will enrol 600 adults aged 70 years and over with normal cognitive function and without overt cardiovascular disease. Subjects will undergo cognitive testing, brain MRI and RVI at baseline and after 3 years of study treatment. All subjects will be recruited from a 19,000-patient clinical outcome trial conducted in Australia and the United States that will evaluate the effects of aspirin in maintaining disability-free longevity over 5 years. The intervention will be aspirin 100 mg daily versus matching placebo, randomized on a 1:1 basis.DiscussionThis study will improve understanding of the mechanisms at the level of brain and vascular structure that underlie the effects of aspirin on cognitive function. Given the limited access and high cost of MRI, RVI may prove useful as a too... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5668630 Wed, 08 Feb 2012 05:00:00 +0100 5668630 http://www.medworm.com/index.php?rid=5649938&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F12%2F1 Conclusions: Our study suggests that short duration (one hour) of supine recumbence may be as efficient as long duration (four hours) of supine recumbence to prevent PLPH. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5649938 Mon, 30 Jan 2012 05:00:00 +0100 5649938 http://www.medworm.com/index.php?rid=5539113&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F157 Background: Progressive supranuclear palsy (PSP) and parkinsonian variant of multiple system atrophy (MSA-P) are clinically difficult to differentiate from idiopathic Parkinson's disease (PD), particularly in the early stages of the disease. Previous reports indicated that the olfactory function is relatively intact or slightly reduced in patients with PSP and MSA-P, suggesting that the odor stick identification test for Japanese (OSIT-J), which is a short and simple noninvasive test that is potentially useful clinically for detecting early-stage PD in Japan, may be useful in the differential diagnosis of early-stage PD from MSA-P and PSP. There is no information on the sensitivity and specificity of OSIT-J in the diagnosis of parkinsonian syndromes such as PSP and MSA-P. Methods: We asses... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5539113 Thu, 22 Dec 2011 05:00:00 +0100 5539113 http://www.medworm.com/index.php?rid=5526885&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F156 Conclusions: Cognitive dysfunction may develop as an isolated neurological manifestation in association with type 1A diabetes and anti-GAD autoimmunity. A systematic study with extensive neuropsychological assessment is indicated in patients with type 1 diabetes and anti-GAD autoimmunity. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5526885 Wed, 21 Dec 2011 05:00:00 +0100 5526885 http://www.medworm.com/index.php?rid=5526886&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F155 Conclusions: The IL-12 receptor shares a common subunit, the IL-12Rbeta2, with the IL-23 receptor. Both of these receptors have a probable role in regulating IL-17 and TH-17 cells, important mediators of inflammation in multiple sclerosis (MS). Thus, the changes in the numbers of CD4+ T-cells expressing these receptors in response to IFN-beta-1a treatment may point to an important mechanism of action for this drug, but further large scale studies are needed to confirm these preliminary observations. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5526886 Mon, 19 Dec 2011 05:00:00 +0100 5526886 http://www.medworm.com/index.php?rid=5506688&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F154 Conclusions: Regardless of the role of metabolic and/or inflammatory factors on the aetiology of the intracranial stenosis in this case, the course of the vessel disease was unexpected and previously unreported in the literature at our knowledge. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5506688 Tue, 13 Dec 2011 05:00:00 +0100 5506688 http://www.medworm.com/index.php?rid=5495885&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F153 At the early onset of the 20th century, several studies already reported that the gray matter was implicated in the histopathology of multiple sclerosis (MS). However, as white matter pathology long received predominant attention in this disease, and histological staining techniques for detecting myelin in the gray matter were suboptimal, it was not until the beginning of the 21st century that the true extent and importance of gray matter pathology in MS was finally recognized. Gray matter damage was shown to be frequent and extensive, and more pronounced in the progressive disease phases. Several studies subsequently demonstrated that the histopathology of gray matter lesions differs from that of white matter lesions. Unfortunately, imaging of pathology in gray matter structures proved to... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5495885 Mon, 12 Dec 2011 05:00:00 +0100 5495885 http://www.medworm.com/index.php?rid=5477918&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F152 The easily identifiable, ubiquitous demyelination and neuronal damage that occurs within the cerebral white matter of patients with multiple sclerosis (MS) has been the subject of extensive study. Accordingly, MS has historically been described as a disease of the white matter. Recently, the cerebral cortex (gray matter) of patients with MS has been recognized as an additional and major site of disease pathogenesis. This acknowledgement of cortical tissue damage is due, in part, to more powerful MRI that allows detection of such injury and to focused neuropathology-based investigations. Cortical tissue damage has been associated with inflammation that is less pronounced to that which is associated with damage in the white matter. There is, however, emerging evidence that suggests cortical ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5477918 Tue, 06 Dec 2011 05:00:00 +0100 5477918 http://www.medworm.com/index.php?rid=5470245&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F151 Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5470245 Fri, 02 Dec 2011 05:00:00 +0100 5470245 http://www.medworm.com/index.php?rid=5459438&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F150 Background Children diagnosed with spastic Cerebral Palsy (CP) often show perceptual and cognitive problems, which may contribute to their functional deficit. Here we investigated if altered ability to determine whether an observed movement is performed by themselves (sense of agency) contributes to the motor deficit in children with CP.Methods Three groups; 1) CP children, 2) healthy peers, and 3) healthy adults produced straight drawing movements on a pen-tablet which was not visible for the subjects. The produced movement was presented as a virtual moving object on a computer screen. Subjects had to evaluate after each trial whether the movement of the object on the computer screen was generated by themselves or by a computer program which randomly manipulated the visual feedback by ang... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5459438 Wed, 30 Nov 2011 05:00:00 +0100 5459438 http://www.medworm.com/index.php?rid=5459439&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F149 Conclusions: Persistent high titers of anti-thyroid peroxidase antibodies from admission to discharge and until one year later in this patient may suggest a propensity to autoimmunity in anti-N-methyl-D-aspartate receptor encephalitis and support the idea that neuronal and thyroid autoimmunities represent a pathogenic spectrum. Enduring anti-N-methyl-D-aspartate receptor antibodies from admission to one year follow-up but seroreversion of Epstein-Barr virus viral capsid antigen IgM may raise the important issue of elucidating the triggers and boosters of anti- N-methyl-D-aspartate receptor encephalitis. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5459439 Tue, 29 Nov 2011 05:00:00 +0100 5459439 http://www.medworm.com/index.php?rid=5423666&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F147 Background: Few data are available on the prevalence of cognitive impairment (CI) in Spain, and the existing information shows important variations depending on the geographical setting and the methodology employed. The aim of this study was to determine the prevalence of CI in individuals aged over 65 in an urban area, and to analyze its associated risk factors. Methods: Design: A descriptive, cross-sectional, home questionnaire-based study; Setting: Populational, urban setting. Participants: The reference population comprised over-65s living in the city of Salamanca (Spain) in 2009. Randomized sampling stratified according to health district was carried out, and a total of 480 people were selected. In all, 327 patients were interviewed (68.10%), with a mean age of 76.35 years (SD: 7.33).... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5423666 Thu, 17 Nov 2011 05:00:00 +0100 5423666 http://www.medworm.com/index.php?rid=5410315&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F145 Conclusions: 13C-methionine-breath-test indicates subclinical hepatic mitochondrial dysfunction in Friedreich ataxia but did not correlate with GAA repeat lengths, disease duration or disease severity. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5410315 Tue, 15 Nov 2011 05:00:00 +0100 5410315 http://www.medworm.com/index.php?rid=5410314&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F146 Conclusions: Our study suggests that the endothelial function in the cerebral and systemic circulation might be different in migraine patients without comorbidities, while that of the anterior and posterior cerebral circulation might be coupled. These results could improve understanding of endothelial function in migraine patients without comorbidities. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5410314 Tue, 15 Nov 2011 05:00:00 +0100 5410314 http://www.medworm.com/index.php?rid=5401631&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F144 Conclusions: Patients on IM IFN beta-1a had fewer ISRs and were less likely to switch therapies than patients on other therapies. This study may have implications in selecting initial therapy or, for patients considering switching or discontinuing therapy because of ISRs, selecting an alternative option. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5401631 Thu, 10 Nov 2011 05:00:00 +0100 5401631 http://www.medworm.com/index.php?rid=5389768&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F142 Conclusions: Our case may contribute to the early recognition of AHS and to explore the abnormal neural mechanism of AHS. To our knowledge, rare reports have ever documented such mixed AHS coexisting secondary to the callosal lesion, based on advanced neuroimaging methods as in our case. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5389768 Wed, 09 Nov 2011 05:00:00 +0100 5389768 http://www.medworm.com/index.php?rid=5389767&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F143 Conclusions: The long-term outcomes of IIM patients in our cohort have improved dramatically. Those patients most likely to survive had a high chance of reaching stable disease status, and obtained long-term or possibly permanent remission to a large extent. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5389767 Wed, 09 Nov 2011 05:00:00 +0100 5389767 http://www.medworm.com/index.php?rid=5389769&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F141 Conclusions: The findings in the FM group may reflect a learned avoidance mechanism away from affective migraine triggers. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5389769 Sat, 05 Nov 2011 04:00:00 +0100 5389769 http://www.medworm.com/index.php?rid=5389772&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F138 Conclusions; We estimated the long-term prognosis of stroke patients with isolated symptomatic MCAD under current medical management in Korea. Diabetes mellitus was found to be a significant predictor for stroke recurrence and mortality (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5389772 Fri, 04 Nov 2011 04:00:00 +0100 5389772 http://www.medworm.com/index.php?rid=5389771&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F139 Conclusion: The impaired glutathione status together with the elevated Trx and TrxR and the remarkable over expression of both Prx I and Prx III, could be used as diagnostic biomarkers of autism. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5389771 Fri, 04 Nov 2011 04:00:00 +0100 5389771 http://www.medworm.com/index.php?rid=5389770&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F140 DiscussionThis ongoing registry includes 609 subjects with the following baseline data: 75.9% female, 93.6% Caucasian, mean age 57.6 +/- 14.3, age at symptom onset 48.3 +/- 16.2, and time to diagnosis 5.4 +/- 8.6 years, with an additional 1.0 +/- 3.5 years before treatment. Of those employed at the time of diagnosis, 36.6% stopped working as a result of CD. CD PROBE, the largest clinical registry of CD treatment, will provide useful data on current treatment practices with onabotulinumtoxinA, potentially leading to refinements for optimization of outcomes.Trial registration: NCT00836017 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5389770 Fri, 04 Nov 2011 04:00:00 +0100 5389770 http://www.medworm.com/index.php?rid=5365245&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F137 Conclusions: The clinicoradiological profile of our patient suggested that dorsal ponto-mesencephalic lesions could contribute to the pathogenesis of PA. Physicians should pay more attention to striking CNS seeding of metastatic NKTL. MTX pulse therapy had an excellent effect in improving serious symptoms and brain lesions in our patient. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5365245 Wed, 02 Nov 2011 04:00:00 +0100 5365245 http://www.medworm.com/index.php?rid=5365246&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F136 Conclusions: In patients with suspected prion disease, a characteristic change in sleep pattern can be an important clinical clue for identifying sFI or FFI; polysomnography (PSG), genetic analysis, and nuclear imaging may aid in diagnosis. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5365246 Mon, 31 Oct 2011 04:00:00 +0100 5365246 http://www.medworm.com/index.php?rid=5365247&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F135 Background: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly(TM) device now also allows supraorbital TNS. During observational clinical studies, several patients reported decreased vigilance or even sleepiness during a session of supraorbital TNS. We decided therefore to explore in more detail the potential sedative effect of supraorbital TNS, using standardized psychophysical tests in healthy volunteers. Methods: We performed a double-blind cross-over sham-controlled study on 30 healthy subjects. They underwent a series of 4 vigilance tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale, d2 test). Each subject was tested under 4 different experimenta... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5365247 Fri, 28 Oct 2011 04:00:00 +0100 5365247 http://www.medworm.com/index.php?rid=5365249&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F133 Conclusions: CSF 14-3-3, tau and S100B proteins are useful diagnostic markers of sCJD even in a low-prevalence clinical population. CSF tau showed better overall diagnostic accuracy than 14-3-3 or S100B. Reporting of quantitative assay results and combining tau with S100B could enhance case definitions used in diagnosis and surveillance of sCJD. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5365249 Thu, 27 Oct 2011 04:00:00 +0100 5365249 http://www.medworm.com/index.php?rid=5365248&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F134 Conclusions: Our findings indicate that demyelinating polyneuropathy and dilated cardiomyopathy are part of the action myoclonus-renal failure syndrome. Moreover, they raise the possibility that in rare cases heterozygous SCARB2 mutations may be associated with PNP features. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5365248 Thu, 27 Oct 2011 04:00:00 +0100 5365248 http://www.medworm.com/index.php?rid=5349603&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F132 Conclusion: The methods for diagnosing CCSVI need to be refined, as the between-centre differences, particularly in single criteria, were excessively high. Despite these discrepancies, the strong associations between CCSVI and MS phenotype suggest that the presence of CCSVI may favour a later development of MS in patients with a lower susceptibility to autoimmune diseases and may increase its severity. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5349603 Wed, 26 Oct 2011 04:00:00 +0100 5349603 http://www.medworm.com/index.php?rid=5349604&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F131 Conclusions: The present report adds clinical and genetic information on this particular and rare MJD presentation, and raises the hypothesis that DJ-1 and APOE polymorphisms may confer susceptibility to the parkinsonian phenotype in MJD. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5349604 Mon, 24 Oct 2011 04:00:00 +0100 5349604 http://www.medworm.com/index.php?rid=5338044&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F129 DiscussionIn order to direct clinicians, patients, and other health decision-makers, there is a need for a head-to-head comparison of different approaches to active, task-related walking training after stroke. We hypothesize that outcomes will be optimized through the application of a task-related training program that is consistent with key motor learning principles related to practice, guidance and feedback.Trial Registration: ClinicalTrials.gov # NCT00561405 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5338044 Fri, 21 Oct 2011 04:00:00 +0100 5338044 http://www.medworm.com/index.php?rid=5338043&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F130 Conclusions: A Chinese family with Cerebrotendinous Xanthomatosis had typical clinical manifestation. CYP27A1 mutations were found in the proband and all other family members. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5338043 Fri, 21 Oct 2011 04:00:00 +0100 5338043 http://www.medworm.com/index.php?rid=5338045&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F128 Background: The potential pathogenesis between the presence and severity of chronic cerebrospinal venous insufficiency (CCSVI) and its relation to clinical and imaging outcomes in brain parenchyma of multiple sclerosis (MS) patients has not yet been elucidated. The aim of the study was to investigate the relationship between CCSVI, and altered brain parenchyma venous vasculature visibility (VVV) on susceptibility-weighted imaging (SWI) in patients with MS and in sex- and age-matched healthy controls (HC). Methods: 59 MS patients, 41 relapsing-remitting and 18 secondary-progressive, and 33 HC were imaged on a 3T GE scanner using pre- and post-contrast SWI venography. The presence and severity of CCSVI was determined using extra-cranial and trans-cranial Doppler criteria. Apparent total veno... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5338045 Wed, 19 Oct 2011 04:00:00 +0100 5338045 http://www.medworm.com/index.php?rid=5316798&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F125 Background: Conventional magnetic resonance imaging (MRI) has improved the diagnosis and monitoring of multiple sclerosis (MS). In clinical trials, MRI has been found to detect treatment effects with greater sensitivity than clinical measures; however, clinical and MRI outcomes tend to correlate poorly. Methods: In this observational study, patients (n=550; 18-50 years; relapsing-remitting MS [Expanded Disability Status Scale score (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5316798 Fri, 14 Oct 2011 04:00:00 +0100 5316798 http://www.medworm.com/index.php?rid=5316797&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F126 Conclusions: The prefilled pen is a safe and effective device for administration of IM IFN beta-1a and represents an alternative method for self-injection for MS patients using this therapy. Trial registration: This study is registered at clinicaltrials.gov, identifier: NCT00828204 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5316797 Fri, 14 Oct 2011 04:00:00 +0100 5316797 http://www.medworm.com/index.php?rid=5305842&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F124 Conclusion: Multidisciplinary outpatient headache centres offer an effective way to establish a three-tier treatment offer for difficult headache patients depending on clinical needs. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5305842 Mon, 10 Oct 2011 04:00:00 +0100 5305842 http://www.medworm.com/index.php?rid=5298167&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F123 Conclusions: : The hygiene hypothesis may play a role in the occurrence of MS and could explain disease distribution and increasing incidence. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5298167 Thu, 06 Oct 2011 04:00:00 +0100 5298167 http://www.medworm.com/index.php?rid=5287322&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F122 Conclusions: Nearly 60% of newly-diagnosed MS patients in this commercial managed care population remained untreated while over a quarter of treated patients stopped therapy and one-sixth experienced treatment gaps despite the risk of disease progression or a return of pre-treatment disease activity. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5287322 Thu, 06 Oct 2011 04:00:00 +0100 5287322 http://www.medworm.com/index.php?rid=5287324&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F120 Conclusion: The 14-3-3 gamma ELISA was more sensitive than conventional WB, and was useful for laboratory diagnosis of CJD, similar to the ELISA for the tau protein. Using DWI-MRI and these ELISA tests on CSF, diagnosis of CJD will be possible even at early stages of the disease. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5287324 Tue, 04 Oct 2011 04:00:00 +0100 5287324 http://www.medworm.com/index.php?rid=5287323&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F121 Conclusions: Our results suggest that plasma 24S-OH-Chol levels might be increased in the first stages of LOAD, and this phenomenon might be related with systemic inflammation. The finding of lower 24S-OH-Chol concentrations in VD might be related with a more advanced stage of VD compared with LOAD in our sample, and/or to different pathogenetic mechanisms and evolution of these two forms of dementia. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5287323 Tue, 04 Oct 2011 04:00:00 +0100 5287323 http://www.medworm.com/index.php?rid=5275546&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F119 Conclusion: Our data indicate that WDR62 mutations cause about 4% of autosomal recessive primary microcephaly in Pakistan. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5275546 Sat, 01 Oct 2011 04:00:00 +0100 5275546 http://www.medworm.com/index.php?rid=5275547&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F118 Conclusion: Substituted judgment of the patient's QoL does not correlate with dementia severity. Substituted judgment is subject to proxy-related variables in a gender-dependent fashion and therefore not suited to serve as an appropriate surrogate of the patients' quality of life. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5275547 Fri, 30 Sep 2011 04:00:00 +0100 5275547 http://www.medworm.com/index.php?rid=5262494&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F117 Conclusion: RLS patients treated with dopaminergic agents and dopamine agonists in particular, should be forewarned of potential side effects. A careful history of risk factors should be taken. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5262494 Wed, 28 Sep 2011 04:00:00 +0100 5262494 http://www.medworm.com/index.php?rid=5262495&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F116 Conclusions: Although the hybrid assistive limb suit is not useful for all hemiplegic patients, it may increase the walking speed and affect the walking ability. Further investigation would clarify its indication for the possibility of gait training. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5262495 Tue, 27 Sep 2011 04:00:00 +0100 5262495 http://www.medworm.com/index.php?rid=5262496&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F115 Conclusion: We found that HAMP usually showed stereotyped clinical features including mild intensity, a dull or pressing quality, localisation ipsilateral to the side of MP use, provocation by prolonged MP use and often accompanied by a burning sensation. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5262496 Mon, 26 Sep 2011 04:00:00 +0100 5262496 http://www.medworm.com/index.php?rid=5252025&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F114 Conclusions: SUA may not be neuroprotective alone, but may provide a beneficial effect in patients receiving thrombolysis. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5252025 Sun, 25 Sep 2011 04:00:00 +0100 5252025 http://www.medworm.com/index.php?rid=5252026&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F113 DiscussionThe theory underlying this approach is that these myelinating progenitors will phenotypically replace myelin lost during injury whilst helping to promote a repair environment in the lesion. However, the importance of demyelination in the pathogenesis of human spinal cord injury is a contentious issue and a body of literature suggests that it is only a minor factor in the overall injury process.SummaryThis review examines the validity of the theory underpinning the on-going clinical trial as well as analysing published data from animal models and finally discussing issues surrounding safety and purity in order to assess the potential of this approach to successfully treat acute human spinal cord injury. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5252026 Fri, 23 Sep 2011 04:00:00 +0100 5252026 http://www.medworm.com/index.php?rid=5252027&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F112 DiscussionIn multiple studies, MAO-B inhibitors, such as selegiline and rasagiline, have shown to provide mild symptomatic effects, delay the need for levodopa, and to reduce the incidence of motor fluctuations. Although their symptomatic efficacy is inferior compared to dopamine agonists and levodopa, MAO-B inhibitors undoubtedly have fewer side effects and are easy to administer. In contrary to their competitors, MAO-B inhibitors may furthermore offer a chance for disease modification, which so far remains a major unmet need in the management of PD and eventually makes them ideal candidates for the early treatment of the disease.SummaryMAO-B inhibitors may constitute a preferable therapeutic option for early PD, mainly due to their favourable safety profile and their putative neuroprotec... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5252027 Thu, 22 Sep 2011 04:00:00 +0100 5252027 http://www.medworm.com/index.php?rid=5239813&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F111 DiscussionPatient recruitment began in June 2009 and the last patient is expected to complete the trial protocol in November 2011.Trial registration:Current controlled trials ISRCTN83178718 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5239813 Wed, 21 Sep 2011 04:00:00 +0100 5239813 http://www.medworm.com/index.php?rid=5239815&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F109 DiscussionThe FUTURE study has the potential to make an important contribution to increase the knowledge on risk factors and long-term prognosis in young stroke patients. Our study differs from previous studies by having a maximal follow-up of more than 30 years, including not only TIA and ischemic stroke but also hemorrhagic stroke, the addition of healthy controls and prospectively collect data during an extensive follow-up visit. Completion of the FUTURE study may provide better information for treating physicians and patients with respect to the prognosis of young stroke (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5239815 Tue, 20 Sep 2011 04:00:00 +0100 5239815 http://www.medworm.com/index.php?rid=5239814&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F110 Background: stroke is the main cause of disability in high-income countries, and ranks second as a cause of death worldwide. Patients with acute stroke are at risk for infections, but reported post-stroke infection rates vary considerably. We performed a systematic review and meta-analysis to estimate the pooled post-stroke infection rate and its effect on outcome. Methods: MEDLINE and EMBASE were searched for studies on post-stroke infection. Cohort studies and randomized clinical trials were included when post-stroke infection rate was reported. Rates of infection were pooled after assessment of heterogeneity. Associations between population- and study characteristics and infection rates were quantified. Finally, we reviewed the association between infection and outcome. Results: 87 stud... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5239814 Tue, 20 Sep 2011 04:00:00 +0100 5239814 http://www.medworm.com/index.php?rid=5185532&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F108 Background: Dynamic cerebral autoregulation after intracerebral hemorrhage (ICH) remains poorly understood. We performed a case-control study to compare dynamic autoregulation between ICH patients and healthy controls. Methods: Twenty-one patients (66+/-15 years) with early ( (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5185532 Tue, 30 Aug 2011 23:00:00 +0100 5185532 http://www.medworm.com/index.php?rid=5147581&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F107 Conclusions: The results of this study indicated that the determinants of stroke phenotypes were different from the predictors (i.e., CHADS2 and CHA2DS2-VASc score) of stroke in patients with AF. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5147581 Tue, 23 Aug 2011 23:00:00 +0100 5147581 http://www.medworm.com/index.php?rid=5147584&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F104 Conclusions: The NPSI-G potentially combines the properties of a diagnostic tool and an instrument to identify subtypes of neuropathic pain. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5147584 Mon, 22 Aug 2011 23:00:00 +0100 5147584 http://www.medworm.com/index.php?rid=5147583&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F105 Conclusions: These results confirm cortical neurometabolic changes in the acute post-concussion phase as well as recovery and continued metabolic abnormalities in the chronic phase. The results indicate that complex pathophysiological processes differ depending on the post-injury phase and the neurometabolite in question. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5147583 Mon, 22 Aug 2011 23:00:00 +0100 5147583 http://www.medworm.com/index.php?rid=5147582&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F106 This study has been reviewed and approved by the medical ethics committee of the region Arnhem-Nijmegen, the Netherlands. The primary outcome measure is quality of life as measured by the EQ-5D, SF-36 and the Individualized neuromuscular Quality of Life Questionnaire. The primary analysis will be an intention-to-treat analysis on the area under the curve of the quality of life scores. A linear mixed model will be used with random factor group and fixed factors treatment, baseline score and type of neuromuscular disease. For the economic evaluation an incremental cost-effectiveness analysis will be conducted from a societal perspective, relating differences in costs to difference in health outcome. Results are expected in 2012.DiscussionThis study will be the first randomized controlled tri... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5147582 Mon, 22 Aug 2011 23:00:00 +0100 5147582 http://www.medworm.com/index.php?rid=5147585&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F103 Conclusions: With a prevalence similar to adults, primary care physicians should be aware of the probability of migraine headaches in university students in order to maintain a successful school performance. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5147585 Thu, 18 Aug 2011 23:00:00 +0100 5147585 http://www.medworm.com/index.php?rid=5133636&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F102 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5133636 Mon, 15 Aug 2011 23:00:00 +0100 5133636 http://www.medworm.com/index.php?rid=5121082&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F101 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5121082 Thu, 11 Aug 2011 23:00:00 +0100 5121082 http://www.medworm.com/index.php?rid=5111297&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F100 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5111297 Tue, 09 Aug 2011 23:00:00 +0100 5111297 http://www.medworm.com/index.php?rid=5111299&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F98 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5111299 Sun, 07 Aug 2011 23:00:00 +0100 5111299 http://www.medworm.com/index.php?rid=5111298&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F99 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5111298 Sun, 07 Aug 2011 23:00:00 +0100 5111298 http://www.medworm.com/index.php?rid=5099068&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F97 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5099068 Thu, 04 Aug 2011 23:00:00 +0100 5099068 http://www.medworm.com/index.php?rid=5099069&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F96 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5099069 Wed, 03 Aug 2011 23:00:00 +0100 5099069 http://www.medworm.com/index.php?rid=5089636&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F95 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5089636 Tue, 02 Aug 2011 23:00:00 +0100 5089636 http://www.medworm.com/index.php?rid=5081384&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F94 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5081384 Sun, 31 Jul 2011 23:00:00 +0100 5081384 http://www.medworm.com/index.php?rid=5081385&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F93 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5081385 Sat, 30 Jul 2011 23:00:00 +0100 5081385 http://www.medworm.com/index.php?rid=5081386&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F92 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5081386 Thu, 28 Jul 2011 23:00:00 +0100 5081386 http://www.medworm.com/index.php?rid=5071858&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F90 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5071858 Tue, 26 Jul 2011 23:00:00 +0100 5071858 http://www.medworm.com/index.php?rid=5071857&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F91 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5071857 Tue, 26 Jul 2011 23:00:00 +0100 5071857 http://www.medworm.com/index.php?rid=5064851&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F89 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5064851 Sun, 24 Jul 2011 23:00:00 +0100 5064851 http://www.medworm.com/index.php?rid=5054147&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F88 ${item.shortDescription} (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5054147 Wed, 20 Jul 2011 23:00:00 +0100 5054147 http://www.medworm.com/index.php?rid=5041639&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F87 This study aims to determine which treatment is more effective, a standardized approach or individualized therapy in patients with homonymous hemianopia post stroke. Methods: This study is a double-blind randomized controlled, multicenter trial. A standardised scanning rehabilitation program (Neuro Vision Technology (NVT) program) of 7 weeks at 3 times per week, is compared to individualized therapy recommended by clinicians.DiscussionThe results of the trial will provide information that could potentially inform the allocation of resources in visual rehabilitation post stroke.Trial Registration: ACTRN12610000494033 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5041639 Mon, 18 Jul 2011 23:00:00 +0100 5041639 http://www.medworm.com/index.php?rid=5022473&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F86 Conclusions: Learning from these couples has resulted in recommendations that challenge the tendency to treat MD1 as a condition with primarily physical impairments. It is vital to listen to couples, to elicit the impact of MD1, as a multisystem disorder that influences every aspect of their life together. Couple management, supporting the self-management skills of both partners is proposed as a way of reducing the mismatch between health services and health needs. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5022473 Tue, 12 Jul 2011 23:00:00 +0100 5022473 http://www.medworm.com/index.php?rid=5022474&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F85 Conclusions: The m.14459G>A might lead to LS, complicated LS or Leber Optic Hereditary Neuropathy. A comprehensive re-evaluation of previously described 14459G>A-mutated patients does not explain this large clinical heterogeneity. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5022474 Mon, 11 Jul 2011 23:00:00 +0100 5022474 http://www.medworm.com/index.php?rid=5001074&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F83 Conclusion: The results of our study suggest that occupational factors do not play a substantial etiologic role in this population. However, among men, professional or technical occupations may decrease the risk of PD. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=5001074 Wed, 06 Jul 2011 23:00:00 +0100 5001074 http://www.medworm.com/index.php?rid=4987447&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F81 Background: Ethnic differences have been reported with regard to several medical therapies. The aim of this study was to investigate the relation between ethnicity and thrombolysis in stroke patients. Methods: Retrospective single-centre study. Patients admitted with an ischemic stroke between 2003 and 2008 were included. Ethnicity was determined by self-identification and stratified into white and non-white (all other ethnicities). The main outcome measure was the difference in thrombolysis rate between white and non-white patients. Logistic regression analysis was used to identify potential confounders of the relation between ethnicity and thrombolysis. Results: 510 patients were included, 392 (77%) white and 118 (23%) non-white. Non-white patients were younger (median 69 vs. 60 years, p... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4987447 Wed, 29 Jun 2011 23:00:00 +0100 4987447 http://www.medworm.com/index.php?rid=4978604&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F79 Conclusions: The results of this study indicate that consumption of PS-DHA at a dosage of 300 mg PS/day for 15 weeks, or 100 mg PS/day for 30 weeks, is safe, well tolerated, and does not produce any negative effects in the tested parameters.Trial registration: clinicaltrials. gov, identifier: NCT00437983 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4978604 Mon, 27 Jun 2011 23:00:00 +0100 4978604 http://www.medworm.com/index.php?rid=4978603&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F80 This study will be the first to test this new type of treatment in childhood. The paper presents the theoretical background, study hypotheses, outcome measures and trial methodology.Trial Registration: NCT01016496 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4978603 Mon, 27 Jun 2011 23:00:00 +0100 4978603 http://www.medworm.com/index.php?rid=4962558&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F78 Conclusions: Pr-AD might be distinguished from S-MCI at baseline using the combination of MMSE and CVLT-LDTR. These two neuropsychological predictors are relatively brief and may be readily completed in non-specialist clinical settings. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4962558 Thu, 23 Jun 2011 23:00:00 +0100 4962558 http://www.medworm.com/index.php?rid=4962561&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F75 DiscussionNeurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies.SummaryIn this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4962561 Wed, 22 Jun 2011 23:00:00 +0100 4962561 http://www.medworm.com/index.php?rid=4962560&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F76 ConclusionThese data suggested that the advantage of MISPT was displayed in minute trauma and safety, and seemed to be feasible and to had a trend towards improved long-term outcome.Trial Registration The Australian New Zealand Clinical Trials Registry (ANZCTR)the registration number:ACTRN12610000945022. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4962560 Wed, 22 Jun 2011 23:00:00 +0100 4962560 http://www.medworm.com/index.php?rid=4962559&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F77 Conclusions: Patients with non-speech dominant hemispheric infarctions and decompressive hemicraniectomy are at high risk of depression and severe cognitive impairment. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4962559 Wed, 22 Jun 2011 23:00:00 +0100 4962559 http://www.medworm.com/index.php?rid=4947341&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F74 DiscussionIt has recently been found that alpha-synuclein may behave similarly to the prion precursor and propagate between cells. The post-mortem proof of alpha-synuclein containing Lewy bodies in embryonic dopamine cells transplants in PD patient suggests that the misfolded protein might be transmitted from the diseased host to donor neurons reminiscent of prion behavior. The involvement of the basal ganglia and brainstem in the degenerative process are other congruencies between Parkinson's and Creutzfeldt-Jakob disease. However, a number of issues advise caution before categorizing Parkinson's disease as a prion disorder, because clinical appearance, brain imaging, cerebrospinal fluid and neuropathological findings exhibit fundamental differences between both disease entities. Most of ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4947341 Sun, 19 Jun 2011 23:00:00 +0100 4947341 http://www.medworm.com/index.php?rid=4939681&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F73 Conclusion: The results of this trial will assist with the development of a model for community-based rehabilitation management for stroke patients and their carers, with emphasis on goal-directed practice to enhance home and community participation status. Facilitation of participation in valued activities may be effective in reducing the incidence or severity of post-stroke depression, as well as enhancing the individual's perception of their health-related quality of life. The engagement of carers in the rehabilitation process will enable review of the influence of the broader social context on recovery.Trial registrationThis trial is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12608000042347) (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4939681 Fri, 17 Jun 2011 23:00:00 +0100 4939681 http://www.medworm.com/index.php?rid=4939682&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F72 Conclusion: Pregnancy may worsen the symptoms of ARJP/PARK2, although appropriate treatments with antiparkinsonian drugs and adequate assistance in the activities of daily living might enable successful pregnancy and birth of healthy children. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4939682 Thu, 16 Jun 2011 23:00:00 +0100 4939682 http://www.medworm.com/index.php?rid=4939683&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F71 Conclusions: Intrathecal lidocaine prior to SNL blunts the response to noxious stimuli by attenuating Nav1.3 up-regulation and suppressing activation of spinal microglia. Although its effects are limited to 3 days, intrathecal lidocaine pretreatment can alleviate acute SNL-induced neuropathic pain. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4939683 Wed, 15 Jun 2011 23:00:00 +0100 4939683 http://www.medworm.com/index.php?rid=4939684&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F70 DiscussionThe FACTS-2-ALS study is the first theory-based randomized controlled trial to evaluate the effects, and the maintenance of effects, of AET and CBT on functioning and QoL in patients with ALS. The results of this study are expected to generate new evidence for the effect of multidisciplinary care of persons with ALS.Trial registration: Dutch Trial Register NTR1616. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4939684 Mon, 13 Jun 2011 23:00:00 +0100 4939684 http://www.medworm.com/index.php?rid=4915415&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F69 Conclusion: Imaging as performed by venous CT-angiography or MR-angiography has a 1 to 2 in 10 chance to detect CVT when typical symptoms are present. D-dimer measurements are of limited clinical value because of false positive and negative results. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4915415 Thu, 09 Jun 2011 23:00:00 +0100 4915415 http://www.medworm.com/index.php?rid=4905753&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F67 Conclusion: The usefulness of clinical variables for predicting the course of MS on an individual basis is limited, despite being associated with the disease course. By training a NNet with the most informative variables we achieved a good accuracy for predicting short-term disability. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4905753 Mon, 06 Jun 2011 23:00:00 +0100 4905753 http://www.medworm.com/index.php?rid=4886850&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F64 Conclusions: Our findings are suggestive of a slowing of information processing for MS patients that may be a consequence of demyelination and axonal degeneration, which also seems to occur in MS patients that show little or no progression in the physical severity of the disease over time. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4886850 Wed, 01 Jun 2011 23:00:00 +0100 4886850 http://www.medworm.com/index.php?rid=4886849&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F65 Conclusion: Varying demands are required for muscles activated during distinctly different postures and ankle movement tasks. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4886849 Wed, 01 Jun 2011 23:00:00 +0100 4886849 http://www.medworm.com/index.php?rid=4886848&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F66 Conclusions: MTHFR C677T is associated with MA in individuals selected for depression study. A meta-analysis of 15 studies supports this association and demonstrated effects across ethnic groups. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4886848 Wed, 01 Jun 2011 23:00:00 +0100 4886848 http://www.medworm.com/index.php?rid=4879042&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F63 Conclusions: Peripheral neuropathy, especially the subtype of axonal sensori-motor neuropathy, is common in patients with CTX. Evidence of lipid metabolic derangement in CTX can be reflected in ultrastructural studies of muscles. With an adequate multi-parametric evaluation, a high incidence of ANS abnormalities can be seen in this rare lipid-storage disease, and a high incidence of small fiber involvement is also reflected in the IENF density measurement of skin biopsies. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4879042 Mon, 30 May 2011 23:00:00 +0100 4879042 http://www.medworm.com/index.php?rid=4874226&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F62 We present analyses of familial clustering of CFS in a computerized genealogical resource linking multiple generations of genealogy data with medical diagnosis data of a large Utah health care system. We compare pair-wise relatedness among cases to expected relatedness in the Utah population, and we estimate risk for CFS for first, second, and third degree relatives of CFS cases. Results: We observed significant excess relatedness of CFS cases compared to that expected in this population. Significant excess relatedness was observed for both close (p (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4874226 Thu, 26 May 2011 23:00:00 +0100 4874226 http://www.medworm.com/index.php?rid=4866319&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F60 This study is registered at clinicaltrials.gov, identifier: NCT01147185. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4866319 Thu, 26 May 2011 23:00:00 +0100 4866319 http://www.medworm.com/index.php?rid=4866318&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F61 Conclusions: Our recommendations can assist in diagnosing Fabry small fiber neuropathy early, and offer clinicians guidance in controlling peripheral pain. This is particularly important since management of pain in young patients with Fabry disease appears to be inadequate.Key words: Diagnosis; Fabry Disease; Neuropathy; Pain; Treatment (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4866318 Thu, 26 May 2011 23:00:00 +0100 4866318 http://www.medworm.com/index.php?rid=4866321&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F58 Conclusions: The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4866321 Wed, 25 May 2011 23:00:00 +0100 4866321 http://www.medworm.com/index.php?rid=4866320&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F59 Conclusions: Ang-1, but not Ang-2, is significantly altered in patients suffering from SAH and especially in those experiencing CVS and cerebral ischemia. The loss of vascular integrity, regulated by Ang-1, might be in part responsible for the development of cerebral vasospasm and subsequent cerebral ischemia. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4866320 Wed, 25 May 2011 23:00:00 +0100 4866320 http://www.medworm.com/index.php?rid=4866322&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F57 Conclusion: The 23 mg/d dose of donepezil was associated with typical cholinergic AEs, particularly gastrointestinal-related AEs, similar to that observed in studies with a dose increase from 5 to 10 mg/d. The good safety and predictable tolerability profile for donepezil 23 mg/d supports its favorable risk/benefit ratio in patients with moderate to severe AD.Trial RegistrationNCT00478205 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4866322 Tue, 24 May 2011 23:00:00 +0100 4866322 http://www.medworm.com/index.php?rid=4856241&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F54 Conclusions: Prospective investigation of a large population of oldest old can contribute significantly to understanding the relations between age, cognitive decline, and dementia occurrence. Use of informant-based instruments in surveys in the oldest old is crucial in assessing everyday functioning and changes, especially in participants with no cognitive test performance available. Failure to include information on deceased elderly would underestimate, increasingly with age, the prevalence of cognitive and functional disability in the elderly population. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4856241 Tue, 24 May 2011 23:00:00 +0100 4856241 http://www.medworm.com/index.php?rid=4856240&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F55 Conclusions: DPN and fibromyalgia patients experience very similar sensory phenomena. The combination of sensory symptoms - the sensory profile - is in most cases distinct and almost unique for each one of the two entities indicating aetiology-specific mechanisms of symptom generation. Beside the unique aetiology-specific sensory profiles an overlap of sensory profiles can be found in 20-35% of patients of both aetiologies. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4856240 Tue, 24 May 2011 23:00:00 +0100 4856240 http://www.medworm.com/index.php?rid=4856239&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F56 This study comprises a non-selected population with first ever stroke and impaired arm function. Measurements are performed both using traditional clinical assessments as well as computer based measurement systems providing objective kinematic data. The ICF classification of functioning, disability and health is used as framework for the selection of assessment measures. The study design with several repeated measurements on motor function will give us more confident information about the recovery patterns after stroke. This knowledge is essential both for optimizing rehabilitation planning as well as providing important information to the patient about the recovery perspectives.Trial registrationClinicalTrials.gov NCT01115348 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4856239 Tue, 24 May 2011 23:00:00 +0100 4856239 http://www.medworm.com/index.php?rid=4856242&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F53 Conclusions: Findings derived from a neuromuscular model suggest that aberrant force feedback regulation from Golgi tendon organs involving an inhibitory interneuron may underpin the typical fixed flexion postures in CRPS patients with dystonia. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4856242 Mon, 23 May 2011 23:00:00 +0100 4856242 http://www.medworm.com/index.php?rid=4833333&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F52 Conclusions: Different age groups with SSCs have different main clinical presentations. VCC appears to be more efficacious than VC. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4833333 Tue, 17 May 2011 23:00:00 +0100 4833333 http://www.medworm.com/index.php?rid=4815026&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F51 Background: Multiple pathogenic factors may contribute to the pathophysiology of Alzheimer's disease (AD). Peripheral blood markers have been used to assess biochemical changes associated with AD and mild cognitive impairment (MCI) and involved in their pathophysiology. Methods: Plasma samples and clinical data were obtained from participants in the Ansan Geriatric Study (AGE study). Plasma concentrations of four candidate biomarkers were measured in the normal control (NC), MCI, and AD group : interleukin-8 (IL-8), IL-10, monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-alpha (TNF-alpha).Body mass index (BMI), MMSE (Mini Mental State Examination), CDR(Clinical Dementia Rating) score and homocystein level were recorded with social and demographic information. Results: ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4815026 Wed, 11 May 2011 23:00:00 +0100 4815026 http://www.medworm.com/index.php?rid=4807575&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F50 Conclusions: Association of a "progressive supranuclear palsy-like" syndrome with marked visuospatial impairment, motor neuron disease and early behavioral disturbances may represent a clinically distinct phenotype of FTLD-TDP. Our observations further support the concept that TDP-43 proteinopathies represent a spectrum of disorders, where preferential localization of pathogenetic inclusions and neuronal cell loss defines clinical phenotypes ranging from frontotemporal dementia with or without motor neuron disease, to corticobasal syndrome and to a progressive supranuclear palsy-like syndrome. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4807575 Mon, 09 May 2011 23:00:00 +0100 4807575 http://www.medworm.com/index.php?rid=4783976&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F49 In this study, We used both DTI and MRS to examine possible secondary damage of thalamus in patients with corona radiata infarction. Methods: Twelve patients with unilateral corona radiata infarction underwent MR imaging including DTI and MRS at one week (W1), four weeks (W4), and twelve weeks (W12) after onset of stroke. Twelve age-matched controls were imaged. Mean diffusivity (MD), fractional anisotropy (FA), N-acetylaspartate (NAA), choline(Cho), and creatine(Cr) were measured in thalami.Results T1-weighted fluid attenuation inversion recovery (FLAIR), T2-weighted, and T2-FLAIR imaging showed an infarct at unilateral corona radiate but no other lesion in each patient brain. In patients, MD was significantly increased at W12, compared to W1 and W4 (all P (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4783976 Wed, 04 May 2011 23:00:00 +0100 4783976 http://www.medworm.com/index.php?rid=4759942&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F48 The objective of this study was to validate a new measure, the Post Sleep Questionnaire (PSQ), to assess sleep dysfunction in subjects with moderate-to-severe RLS symptoms. Methods: Pooled data were analyzed from 2 12-week, randomized, placebo-controlled trials of gabapentin enacarbil (N=540). At baseline and Week 12, subjects completed the PSQ and other validated health surveys: IRLS Rating Scale, Clinical Global Impression of Improvement (CGI-I), Profile of Mood States (POMS), Medical Outcomes Study Scale-Sleep (MOS-Sleep), and RLS-Quality of Life (RLSQoL). Pooled data were used post hoc to examine the convergent, divergent, and known-group validity and the responsiveness of the PSQ. Results: Convergent validity was demonstrated by significant correlations between baseline PSQ items and ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4759942 Wed, 27 Apr 2011 23:00:00 +0100 4759942 http://www.medworm.com/index.php?rid=4755581&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F47 Background: Guidelines recommend maintaining the heart rate (HR) of acute stroke patients within physiological limits; data on the frequency and predictors of significant deviations from these limits are scarce. Methods: Demographical data, stroke risk factors, NIH stroke scale score, lesion size and location, and ECG parameters were prospectively assessed in 256 patients with ischemic stroke. Patients were continuously monitored for at least 24 hours on a certified stroke unit. Tachycardia (HR [greater than or equal to]120 bpm) and bradycardia (HR (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4755581 Tue, 26 Apr 2011 23:00:00 +0100 4755581 http://www.medworm.com/index.php?rid=4727264&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F46 Conclusions: The main conclusion of this study is that ABD has a high impact in both epidemiological and economic terms as well as loss in quality of life. The overall prevalence obtained is equivalent to 0.7% of the total population. The substantial economic burden is distributed nearly evenly between formal and informal costs. Specifically, it was found that the physical dimensions of quality of life are the most severely affected. The prevalence-based approach showed adequate to estimate the population impact of ABD and the resources needed to compensate the disability. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4727264 Sun, 17 Apr 2011 23:00:00 +0100 4727264 http://www.medworm.com/index.php?rid=4711175&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F45 We noticed after publication that there are errors in Table two of our article, recently published in BMC Neurology.Please find the corrections below:1) A 2.82 is missing in column VM.2) The superscripts in column BPPV are superfluous, as the last two questions allow only oneanswer each, as detailed in the caption.These corrections are included in the spreadsheet files we offered upon request in the article. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4711175 Wed, 13 Apr 2011 23:00:00 +0100 4711175 http://www.medworm.com/index.php?rid=4666094&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F43 Pain in general and headache in particular are characterized by a change in activity in brain areas involved in pain processing. The therapeutic challenge is to identify drugs with molecular targets that restore the healthy state, resulting in meaningful pain relief or even freedom from pain. Different aspects of pain perception, i.e. sensory and affective components, also explain why there is not just one single target structure for therapeutic approaches to pain. A network of brain areas ("pain matrix") are involved in pain perception and pain control. This diversification of the pain system explains why a wide range of molecularly different substances can be used in the treatment of different pain states and why in recent years more and more studies have described a superior efficacy of... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4666094 Wed, 30 Mar 2011 23:00:00 +0100 4666094 http://www.medworm.com/index.php?rid=4660043&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F42 Conclusions: This study provides valuable insight into the wellbeing of patients living at home one year post stroke. Physical functioning and quality of life are comparable to the general population of the same age, but improvements in mental functioning can be envisaged. In addition, more attention should be paid to maintaining the patients' activities. The wellbeing of these stroke patients could be increased further if greater attention is paid to these aspects of life. This seems to be applicable to general practice. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4660043 Wed, 30 Mar 2011 23:00:00 +0100 4660043 http://www.medworm.com/index.php?rid=4660044&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F41 Background: Study aimed at investigation of pathogenic role and prognostic value of several selected cerebrospinal fluid acute phase factors that can reflect the severity of ischemic brain damage. Methods: Ninety five acute ischemic stroke patients were investigated. Ischemic region visualized at the twenty fourth hour by conventional Magnetic Resonance Imaging. Stroke severity evaluated by National Institute Health Stroke Scale. One month outcome of disease was assessed by Barthel Index. Cerebrospinal fluid was taken at the sixth hour of stroke onset. CSF pro- and anti-inflammatory cytokines were studied by Enzyme Linked Immunosorbent Assay. Nitric Oxide and Lipoperoxide radical were measured by Electron Paramagnetic Resonance. CSF Nitrate levels were detected using the Griess reagent. St... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4660044 Tue, 29 Mar 2011 23:00:00 +0100 4660044 http://www.medworm.com/index.php?rid=4654981&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F39 Conclusion: Edaravone treatment reduced the volume of the infarct and improved neurological deficits during the subacute period, especially in the small-vessel occlusion strokes. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4654981 Tue, 29 Mar 2011 23:00:00 +0100 4654981 http://www.medworm.com/index.php?rid=4646088&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F38 Background: To examine age and sex specific incidence and 30 day case fatality for subarachnoid haemorrhage (SAH) in Scotland over a 20 year period. Methods: A retrospective cohort study using routine hospital discharge data linked to death records. Results: Between 1986 and 2005, 12,056 individuals experienced an incident SAH. Of these 10,113 (84%) survived to reach hospital. Overall age-standardised incidence rates were greater in women than men and remained relatively stable over the study period. In 2005, incidence in women was 12.8 (95% CI 11.5 to 14.0) and in men 7.9 (95% CI 6.9 to 9.1). 30 day case fatality in individuals hospitalised with SAH declined substantially, falling from 30.0% in men and 33.9% in women in 1986-1990 to 24.5% in men and 29.1% in women in 2001-2005. For both m... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4646088 Mon, 28 Mar 2011 23:00:00 +0100 4646088 http://www.medworm.com/index.php?rid=4628267&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F36 ConclusionTreatment of SMA patients with VPA may be a potential alternative to alleviate the progression of the disease. TrialRegistrationcurrent control trials NCT01033331. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4628267 Thu, 24 Mar 2011 00:00:00 +0100 4628267 http://www.medworm.com/index.php?rid=4628266&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F37 Conclusions: The clinical and sleep features of chronic post-SARS form a syndrome of chronic fatigue, pain, weakness, depression and sleep disturbance, which overlaps with the clinical and sleep features of FMS and chronic fatigue syndrome. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4628266 Thu, 24 Mar 2011 00:00:00 +0100 4628266 http://www.medworm.com/index.php?rid=4572091&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F34 Conclusion: Bulbar central pattern generators coordinate the pharyngeal swallowing phase. The observed right hemispheric lateralization in brainstem stroke can therefore be interpreted as acute cortical compensation of subcortically caused dysphagia. The reduction of activation in brainstem stroke patients and dysphagic patients with cortical stroke could be explained in terms of diaschisis. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4572091 Fri, 11 Mar 2011 00:00:00 +0100 4572091 http://www.medworm.com/index.php?rid=4556042&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F31 Background: Celiac disease (CD) is a common systemic disease related to a permanent intolerance to gluten and is often associated with different autoimmune and neurological diseases. Its mean prevalence in the general population is 1-2% worldwide. Our aim was to study the prevalence of celiac disease in a prospective series of Multiple Sclerosis (MS) patients and their first-degree relatives. Methods: We analyzed the prevalence of serological, histological and genetic CD markers in a series of 72 MS patients and in their 126 first-degree relatives, compared to 123 healthy controls. Results: Tissue IgA-anti-transglutaminase-2 antibodies were positive in 7 MS patients (10%), compared to 3 healthy controls (2.4%) (p (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4556042 Mon, 07 Mar 2011 00:00:00 +0100 4556042 http://www.medworm.com/index.php?rid=4525713&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F28 Conclusion: The EURLSSG task force reached a consensus and agreed on the diagnostic and treatment algorithms published here. An electronic version of the diagnostic algorithm is available online on the EULRSSG website: http://www.EURLSSG.com (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4525713 Sun, 27 Feb 2011 00:00:00 +0100 4525713 http://www.medworm.com/index.php?rid=4518885&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F26 Background: In daily clinical setting, some patients affected by relapsing-remitting Multiple Sclerosis (RRMS) are switched from the low-dose to the high-dose Interferon beta (IFNB) in order to achieve a better control of the disease. In this observational, post-marketing study we reported the 2-year clinical outcomes of patients switched to the high-dose IFNB; we also evaluated whether different criteria adopted to switch patients had an influence on the clinical outcomes. Methods: Patients affected by RRMS and switched from the low-dose to the high-dose IFNB due to the occurrence of relapses, or contrast-enhancing lesions (CELs) as detected by yearly scheduled MRI scans, were followed for two years. Expanded Disability Status Scale (EDSS) scores, as well as clinical relapses, were evalua... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4518885 Fri, 25 Feb 2011 00:00:00 +0100 4518885 http://www.medworm.com/index.php?rid=4518884&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F27 Background: Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized to correlate with the symptom of fatigue. The need to investigate this association has been highlighted. The aim of the study was to investigate the occurrence of heat sensitivity and its relations to disease course, disability, common MS-related symptoms and ongoing immunosuppressive treatments among individuals 65 years or younger diagnosed with MS.MethodA cross-sectional designed survey was undertaken. A questionnaire was sent to MS-patients with an Expanded Disability Status Score (EDSS) in the interval 0-6.5 and between 20 and 65 years of age, living in an eastern region of Sweden (n=334). Besides occurrence of heat sensitivity (Yes/No) and corresp... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4518884 Fri, 25 Feb 2011 00:00:00 +0100 4518884 http://www.medworm.com/index.php?rid=4491367&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F22 Discussion: The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4491367 Thu, 17 Feb 2011 00:00:00 +0100 4491367 http://www.medworm.com/index.php?rid=4443100&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F21 Of the estimated 5.3 million people with Alzheimer's disease in the United States, more than half would be classified as having moderate or severe disease. Alzheimer's disease is a progressive disorder with the moderate to severe stages generally characterized by significant cognitive, functional, and behavioral dysfunction. Unsurprisingly, these advanced stages are often the most challenging for both patients and their caregivers/families. Symptomatic treatments for moderate to severe Alzheimer's disease are approved in the United States and include the acetylcholinesterase inhibitor donepezil and the glutamate receptor antagonist memantine. Progressive symptomatic decline is nevertheless inevitable even with the available therapies, and therefore additional treatment options are urgently... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4443100 Mon, 07 Feb 2011 00:00:00 +0100 4443100 http://www.medworm.com/index.php?rid=4415993&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F16 Background: We aimed to examine current practice of the management and secondary prevention of intracerebral haemorrhage (ICH) in China where the disease is more common than in Western populations. Methods: Data on baseline characteristics, management in-hospital and post-stroke, and outcome of ICH patients are from the ChinaQUEST (QUality Evaluation of Stroke Care and Treatment) study, a multi-centre, prospective, 62 hospital registry in China during 2006-07. Results: Nearly all ICH patients (n=1572) received an intravenous haemodiluting agent such as mannitol (96%) or a neuroprotectant (72%), and there was high use of intravenous traditional Chinese medicine (TCM) (42%). Neurosurgery was undertaken in 137 (9%) patients; being overweight, having a low Glasgow Coma Scale (GCS) score on adm... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4415993 Sun, 30 Jan 2011 00:00:00 +0100 4415993 http://www.medworm.com/index.php?rid=4407772&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F14 The objective of this study is to determine whether the addition of CSS improves diagnostic accuracy of stroke triage. Methods: This prospective experimental study will be conducted during a one-year period in the 911 call center of Santa Clara County, CA. We will include callers aged > 18 years with a chief complaint suggestive of stroke and second party callers (by-stander or family who are in close proximity to the patient and can administer the tool) > 18 years of age. Life threatening calls will be excluded from the study. Card 28 questions will be administered to subjects who meet study criteria. After completion of Card 28, CSS tool will be administered to all calls. EMDs will record their initial assessment of a cerebro-vascular accident (stroke) after completion of Card 28 and the... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4407772 Thu, 27 Jan 2011 00:00:00 +0100 4407772 http://www.medworm.com/index.php?rid=4407771&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F15 Background: The major difficulty in postoperative care in patients after craniotomy is to distinguish the intracranial deficits from the residual effect of general anesthesia. In present study, we used cerebral state index (CSI) monitoring in patients after craniotomy with delayed recovery, and evaluated the prediction probability of CSI for long-term postoperative unconsciousness. Methods: We enrolled 57 consecutive adult patients admitted to neurosurgical intensive care unit (NICU) after elective craniotomy with delayed recovery. CSI was continuously monitored for 6 hours after admission. Patient's level of consciousness was followed up for 24 hours. According to whether obeyed verbal command, patients were divided into awaken group and non-awaken group. CSI values were compared between ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4407771 Thu, 27 Jan 2011 00:00:00 +0100 4407771 http://www.medworm.com/index.php?rid=4401901&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F12 Conclusion ASCI was found in 18.9% (7/37) of HIV-negative CM adults. Serial MRI follow-up studies may allow a better delineation of ASCI in this specific group of infectious disease and multiple lacunar infarctions was the most common type. Older in age and presence of DM and previous stroke were the significant underlying conditions. CM patients with ASCI also had a poor therapeutic outcome. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4401901 Wed, 26 Jan 2011 00:00:00 +0100 4401901 http://www.medworm.com/index.php?rid=4401900&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F13 Background: The clinical presentation in progressive supranuclear palsy (PSP), an atypical parkinsonian disorder, includes varying degrees of frontal dysexecutive symptoms. Using diffusion tensor imaging (DTI) and tractography (DTT), we investigated whether diffusion changes and atrophy of the inferior fronto-occipital fasciculus (IFO) occurs in PSP and if these changes correlate with disease stage and clinical phenotype. The corticospinal tract (CST), which is often involved in PSP, was investigated for comparison. Methods: DTI of the whole brain was performed with a 3T MR scanner using a single shot-EPI sequence with diffusion encoding in 48 directions. Scans were obtained in patients with PSP (n=13) and healthy age-matched controls (n=12). DTT of the IFO and CST was performed with the P... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4401900 Wed, 26 Jan 2011 00:00:00 +0100 4401900 http://www.medworm.com/index.php?rid=4395818&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F10 DiscussionThe proposed research project will be the first study to provide data about the cost-effectiveness of the ketogenic diet for children and adolescents with intractable epilepsy, in comparison with usual care. It is anticipated that positive results in (cost-) effectiveness of the proposed intervention will contribute to the improvement of treatment for epilepsy in children and adolescents and will lead to a smaller burden to society.Trial registration: The study has been registered with the Netherlands Trial Registry (NTR2498). (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4395818 Tue, 25 Jan 2011 00:00:00 +0100 4395818 http://www.medworm.com/index.php?rid=4395817&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F11 DiscussionBimanual coordination emerges as an active, task-specific assembling process where the limbs are constrained to act as a single unit by virtue of mutual coupling. Consequently, exploring, assessing, re-establishing and exploiting functional bimanual synergies following stroke, require moving beyond the classical characterization of performance of each limb in separate and isolated fashion, to study coupling signatures at both neural and behavioural levels. Grounded on the conceptual framework of the dynamic system approach to bimanual coordination, we debated on two main assumptions: 1) stroke-induced impairment of bimanual coordination might be anticipated/understood by comparing, in join protocols, changes in coupling strength and asymmetry of bimanual discrete movements observ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4395817 Tue, 25 Jan 2011 00:00:00 +0100 4395817 http://www.medworm.com/index.php?rid=4390675&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F9 Conclusions: These results suggest that patients with schwannomas have a significant probability of carrying a SMARCB1 mutation. Combined with data available from other studies, they confirm the clinical indications for genetic screening of the SMARCB1 gene. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4390675 Mon, 24 Jan 2011 00:00:00 +0100 4390675 http://www.medworm.com/index.php?rid=4379263&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F8 Conclusions: CT angiography is self-reliant to exclude ruptured aneurysms when either a perimesencephalic hemorrhage or no-hemorrhage pattern is identified on the CT within a week of symptom onset. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4379263 Fri, 21 Jan 2011 00:00:00 +0100 4379263 http://www.medworm.com/index.php?rid=4379264&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F7 The objective was to analyze the effect of pregabalin (PGB) on pain alleviation and longitudinal health and non-health resources utilization and derived costs in peripheral refractory NeP in routine medical practice in primary care settings (PCS) in Spain. Methods: Subjects from PCS were older than 18 years, with peripheral NeP (diabetic neuropathy, post-herpetic neuralgia or trigeminal neuralgia), refractory to at least one previous analgesic, and included in a prospective, real world, and 12-week two-visit cost-of-illness study. Measurement of resources utilization included both direct healthcare and indirect expenditures. Pain severity was measured by the Short Form-McGill Pain Questionnaire (SF-MPQ). Results: One-thousand-three-hundred-fifty-four PGB-naive patients [58.8% women, 59.5 (... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4379264 Thu, 20 Jan 2011 00:00:00 +0100 4379264 http://www.medworm.com/index.php?rid=4357231&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F5 Conclusion: The present study reveals that there are significant variations in the CW among intra and inter ethnic groups (Caucasian, African and Asian: Iran and Sri Lanka dominant populations), and warrants further studies keeping the methods of measurements, data assessment, and the definitions of hypoplasia the same. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4357231 Mon, 17 Jan 2011 00:00:00 +0100 4357231 http://www.medworm.com/index.php?rid=4327966&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F3 This study is designed to examine how clinical, psychological factors, socioeconomic circumstances, and healthcare delivery influence the experience of epilepsy for individuals and families allowing better targeting of specific services and informing policy makers and practitioners. In addition, the study will provide the basis for a longitudinal population-based cohort study and potentially inform qualitative sub-studies and randomised controlled trials of intervention strategies.The study has been registered on the Australia New Zealand Clinical Trial Registration database with ANZCTRN12609000059268. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4327966 Sun, 09 Jan 2011 00:00:00 +0100 4327966 http://www.medworm.com/index.php?rid=4319621&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F2 Conclusions: In Korea, stroke awareness not only on the part of patients, but also of bystanders, had a great impact on early arrival at hospital. To increase the rate of thrombolysis therapy and the incidence of favorable outcomes, extensive general public education including how to recognize stroke symptoms would be important. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4319621 Thu, 06 Jan 2011 00:00:00 +0100 4319621 http://www.medworm.com/index.php?rid=4315284&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F1 Conclusions: Our evidence suggests that the current practice of treating Bell's palsy with AVT plus corticosteroid may lead to slightly higher recovery rates compared to treating with prednisone alone but this does not quite reach statistical significance; prednisone remains the best evidence-based treatment. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4315284 Wed, 05 Jan 2011 00:00:00 +0100 4315284 http://www.medworm.com/index.php?rid=4299490&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F124 Conclusions: Under-nutrition is a problem for around 15% of community dwelling people with PD. All PD patients should be screened for under-nutrition; the MUST score is a useful early screening tool. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4299490 Thu, 30 Dec 2010 00:00:00 +0100 4299490 http://www.medworm.com/index.php?rid=4299489&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F125 Background: Though vascular factors may be important in the aetiology of late-life depression, it is not clear whether they have a major effect on the risk of depression after a stroke. We investigated the relationship between physiological, biochemical, neuro-imaging and socio-economic factors and late-phase post-stroke depression in a cross-sectional case-control study. Methods: People living at home at least 9 months after a stroke were interviewed using a structured proforma. Depression was diagnosed according to DSM-IV criteria, together with a Montgomery Asberg (MADRS) score >17. Stroke survivors of similar age and functional status but without symptoms of, or recent treatment for, depression and with MADRS score (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4299489 Thu, 30 Dec 2010 00:00:00 +0100 4299489 http://www.medworm.com/index.php?rid=4297126&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F123 Background: In patients with patent foramen ovale (PFO) there is evidence supporting the hypothesis of a change in right-to-left shunt (RLS) over time. Proven, this could have implications for the care of patients with PFO and a history of stroke. The following study addressed this hypothesis in a cohort of patients with stroke and PFO. Methods: The RLS volume assessed during hospitalisation for stroke (index event/T0) was compared with the RLS volume on follow-up (T1) (median time between T0 and T1 was 10 months). In 102 patients with a history of stroke and PFO the RLS volume was re-assessed on follow-up using contrast-enhanced transcranial Doppler/duplex (ce-TCD) ultrasound. A change in RLS volume was defined as a difference of at least 20 microembolic signals (MES) or no evidence of RL... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4297126 Wed, 29 Dec 2010 00:00:00 +0100 4297126 http://www.medworm.com/index.php?rid=4234938&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F121 Conclusion: Acquired synesthesia, exclusively coincident with migraine aura, gives support to the idea of an anomalous cortical processing underlying the phenomenon. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4234938 Tue, 07 Dec 2010 00:00:00 +0100 4234938 http://www.medworm.com/index.php?rid=4227079&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F120 Conclusions: This report shows the usefulness of multimodal MR imaging in achieving early diagnosis during an acute neurological attack of HaNDL. Our experience, along with that of others, demonstrates that neuroimaging tests reveal the presence of cerebral hypoperfusion in HaNDL syndrome (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4227079 Thu, 02 Dec 2010 00:00:00 +0100 4227079 http://www.medworm.com/index.php?rid=4222026&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F119 Conclusions: The absence of differences in endothelium-dependent vasodilation, basal endothelial nitric oxide production and stimulated t-PA release between migraine patients and healthy control subjects argues against the presence of endothelial dysfunction in forearm resistance vessels of migraine patients. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4222026 Wed, 01 Dec 2010 00:00:00 +0100 4222026 http://www.medworm.com/index.php?rid=4216320&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F117 Conclusions: A clinician should consider LNB when being confronted with an HIV patient with focal encephalitis, without any history of Lyme disease or tick bites, in an endemic area. Rapid diagnosis and treatment is necessary in order to minimize severe sequelae. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4216320 Tue, 30 Nov 2010 00:00:00 +0100 4216320 http://www.medworm.com/index.php?rid=4216319&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F118 Conclusions: He made a marked recovery after further treatment with high dose steroids and plasma exchange. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4216319 Tue, 30 Nov 2010 00:00:00 +0100 4216319 http://www.medworm.com/index.php?rid=4184785&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F116 Conclusions: Little evidence is available relevant to the treatment of refractory neuropathic pain despite the clinical need. There is a notable lack of high-quality comparative studies. It is evident that there is a need for future, high quality trials, particularly "gold-standard" RCTs in this refractory patient population. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4184785 Fri, 19 Nov 2010 00:00:00 +0100 4184785 http://www.medworm.com/index.php?rid=4173290&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F115 Conclusions: Congenital anomalies thus do not appear to be associated with MS. However, we did not have complete data on types and severity of congenital anomalies or on maternal birth history and thus this study should be regarded as preliminary. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4173290 Tue, 16 Nov 2010 00:00:00 +0100 4173290 http://www.medworm.com/index.php?rid=4169452&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F114 Conclusions: Our data demonstrates that ultrasound-mediated BBB disruption causes an activation of the Akt signaling pathway in neuronal cells surrounding the disrupted BBB. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=4169452 Mon, 15 Nov 2010 00:00:00 +0100 4169452