MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Neurology' source. Sat, 20 Mar 2010 14:40:35 +0100 http://www.medworm.com/index.php?rid=3376164&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F19 DiscussionTo our knowledge this is the first randomised controlled trial of platelet transfusion for an acute haemorrhagic disease.Trial registrationThe Netherlands National Trial Register (NTR1303) (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3376164 Thu, 18 Mar 2010 00:00:00 +0100 3376164 http://www.medworm.com/index.php?rid=3352142&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F18 This study aimed at investigating whether migraine patients present an altered response to NO also in the peripheral artery system. Methods: We enrolled 21 migraineurs (10 with aura [MwA], 11 without aura [MwoA]), and 13 controls. FMD was evaluated with ultrasound in all subjects by measuring the percentage increase of the brachial artery diameter induced by hyperaemia reactive to sustained cuff inflation around the arm above systolic pressure. FMD values were then normalized for shear stress. Results: Normalized FMD values were higher in patients with MwA (28.5 10-2%.s) than in controls (9.0 10-2%.s) and patients with MwoA (13.7 10-2%.s) (p (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3352142 Wed, 10 Mar 2010 00:00:00 +0100 3352142 http://www.medworm.com/index.php?rid=3344576&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F17 Conclusion: This study identified new variants of the SPAST gene which included benign missense variants and short insertions/deletions. No large rearrangements were found. Based on these data, 7 new pathogenic variants of HSP are associated with clinical phenotypes. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3344576 Tue, 09 Mar 2010 00:00:00 +0100 3344576 http://www.medworm.com/index.php?rid=3277855&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F14 DiscussionThis research will be an important first step in quantifying the effect of an exercise intervention on cognitive and daily function among seniors with sub-cortical ischaemic vascular cognitive impairment, a recognized risk state for progression to dementia. Exercise has the potential to be an effective, inexpensive, and accessible intervention strategy with minimal adverse effects. Reducing the rate of cognitive decline among seniors with sub-cortical ischaemic vascular cognitive impairment could preserve independent functioning and quality of life in this population. This, in turn, could lead to reduced health care utilization costs and avoidance of early institutional care. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3277855 Wed, 17 Feb 2010 00:00:00 +0100 3277855 http://www.medworm.com/index.php?rid=3252473&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F12 Conclusions: Apart from an association between listening to music on a daily basis and overall headache, no consistent associations between the use of electronic media and different types of headache were observed. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3252473 Tue, 09 Feb 2010 00:00:00 +0100 3252473 http://www.medworm.com/index.php?rid=3222014&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F11 In clinical neurology, a comprehensive understanding of consciousness has been regarded as an abstract concept - best left to philosophers. However times are changing and the need to clinically assess consciousness is increasingly becoming a real-world, practical challenge. Current methods for evaluating altered levels of consciousness are highly reliant on either behaviour measures or anatomical imaging. While these methods have some utility, estimates of misdiagnosis are worrisome (as high as 43%) - clearly this is a major clinical problem. The solution must involve objective, physiologically based measures that do not rely on behaviour. This paper reviews recent advances in physiologically based measures that enable better evaluation of consciousness states (coma, vegetative state, mini... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3222014 Fri, 29 Jan 2010 00:00:00 +0100 3222014 http://www.medworm.com/index.php?rid=3218551&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F10 Conclusion: Our data suggest that the natural food supplement Co-Q is potentially efficacious and tolerable in the treatment of CVS, and should be considered as an option in CVS prophylaxis. Our data would likely be helpful in the design of a double-blind clinical trial. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3218551 Thu, 28 Jan 2010 00:00:00 +0100 3218551 http://www.medworm.com/index.php?rid=3191217&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F9 Conclusions: Our study shows that TCS is a reliable and highly sensitive tool for differentiation of IPD patients from individuals without CNS disorders. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3191217 Thu, 21 Jan 2010 00:00:00 +0100 3191217 http://www.medworm.com/index.php?rid=3183717&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F8 DiscussionA major strength of the FACTS-2-PPS study is the use of a mixed methods design in which a responsive and economic evaluation runs parallel to the trial. The results of this study will generate new evidence for the rehabilitation treatment of persons with PPS.Trial registration: Dutch Trial Register NTR1371. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3183717 Mon, 18 Jan 2010 00:00:00 +0100 3183717 http://www.medworm.com/index.php?rid=3173925&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F6 Conclusion: In this large population-based study, smoking was associated with ALS risk and worse survival in women but not in men. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3173925 Thu, 14 Jan 2010 00:00:00 +0100 3173925 http://www.medworm.com/index.php?rid=3173924&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F7 Conclusions: Our study demonstrated that a structured interview based on the ICHD criteria is a useful and valid tool to identify migraine in research settings and to a limited extent in clinical settings, and could be used in studies on large samples where clinical interviews are less practical. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3173924 Thu, 14 Jan 2010 00:00:00 +0100 3173924 http://www.medworm.com/index.php?rid=3161445&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F4 This study aims to compare the efficacy of CIMT to BIM training to improve outcomes across the International Classification of Functioning, Disability and Health (ICF) for school children with congenital hemiplegia. Methods: A matched pairs randomised comparison design will be used with children matched by age, gender, side of hemiplegia and level of upper limb function. Based on power calculations a sample size of 52 children (26 matched pairs) will be recruited. Children will be randomised within pairs to receive either CIMT or BIM training. Both interventions will use an intensive activity based day camp model, with groups receiving the same dosage of intervention delivered in the same environment (total 60 hours over 10 days). A novel circus theme will be used to enhance motivation. Gr... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3161445 Tue, 12 Jan 2010 00:00:00 +0100 3161445 http://www.medworm.com/index.php?rid=3147504&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F3 DiscussionIf effective, this multimodal intervention could be delivered in both urban and rural environments. For example, existing infrastructure such as regional stroke centers and existing secondary stroke prevention clinics, make this intervention, if effective, deliverable and sustainable.Trial Registration: ISRCTN95662526 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3147504 Wed, 06 Jan 2010 00:00:00 +0100 3147504 http://www.medworm.com/index.php?rid=3144245&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F10%2F1 Conclusions: The clinical profile of PD in Nigerians is similar to that in other populations, but is characterized by delayed presentation as has been reported in other developing countries. Young-onset disease occurs but may be less commonly encountered, and frequency of a positive family history is lower than in western populations. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3144245 Tue, 05 Jan 2010 00:00:00 +0100 3144245 http://www.medworm.com/index.php?rid=3109478&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F63 Conclusions: Parallel reductions of CSF sAPPalpha and sAPPbeta in ADC and CNS opportunistic infections suggest an effect of CNS immune activation or inflammation on neuronal amyloid synthesis or processing. Elevation of CSF t-tau in some ADC and CNS infection patients without concomitant increase in p-tau indicates neural injury without preferential accumulation of hyperphosphorylated tau as found in Alzheimer's disease. These biomarker changes define pathogenetic pathways to brain injury in ADC that differ from those of Alzheimer's disease. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3109478 Tue, 22 Dec 2009 00:00:00 +0100 3109478 http://www.medworm.com/index.php?rid=3103248&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F62 Conclusions: TBZ effectively suppresses HD-related chorea for up to 80 weeks. Patients treated chronically with TBZ should be monitored for parkinsonism, dysphagia and other side effects including sleep disturbance, depression, anxiety, and akathisia. Clinicaltrials.gov registration number (initial study): NCT00219804 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3103248 Fri, 18 Dec 2009 00:00:00 +0100 3103248 http://www.medworm.com/index.php?rid=3083664&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F61 Conclusion: Frequency of seizures is the only predictive factor for the success of seizure control in NKHS. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3083664 Mon, 14 Dec 2009 00:00:00 +0100 3083664 http://www.medworm.com/index.php?rid=3069006&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F60 DISCUSSION The aim of this study is to describe the incidence of mismatch and the predictive value of PI for final lesion size and functional outcome depending on delay of imaging and vascular recanalization. It is crucial to standardize PI for future randomized clinical trials as for individual therapeutic decisions and we expect to contribute to this challenging task.TRIAL REGISTRATION clinicaltrials.gov NCT00715533 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3069006 Tue, 08 Dec 2009 00:00:00 +0100 3069006 http://www.medworm.com/index.php?rid=3054483&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F59 Conclusions: We found evidence that combined THC and CBD extracts may provide therapeutic benefit for MS spasticity symptoms. Although some objective measures of spasticity noted improvement trends, there were no changes found to be significant in post-treatment assessments. However, subjective assessment of symptom relief did often show significant improvement post-treatment. Differences in assessment measures, reports of adverse events, and dosage levels are discussed. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3054483 Fri, 04 Dec 2009 00:00:00 +0100 3054483 http://www.medworm.com/index.php?rid=3041754&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F58 We report the first such study conducted in an urban slum of Karachi, Pakistan. Methods: Individuals 35 years of age or older were invited for participation in this investigation through simple random sampling. A structured face-to-face interview was conducted using a pre-tested stroke symptom questionnaire in each participant to screen for past stroke or TIA followed by neurological examination of suspected cases. Anthropometric measurements and random blood glucose levels were recorded. Data was analyzed using Stata v10.0. Multivariable logistic regression was used to determine the association of pre-specified covariates with the prevalence of stroke. Results: 545 individuals (49.4% of them were females) participated in the study with a response rate of 76.8%. 104 individuals (19.1%) wer... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=3041754 Tue, 01 Dec 2009 00:00:00 +0100 3041754 http://www.medworm.com/index.php?rid=2965324&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F57 DiscussionULTRA-stroke is a 3-year translational research program which aims (1) to assess the relative effectiveness of the three interventions, on a group level but also as a function of patient characteristics, and (2) to delineate the functional and neurophysiological changes that are induced by those interventions.The outcome on the ARAT together with information about changes in the associated mechanisms will provide a better understanding of how specific therapies influence neurobiological changes, and which post-stroke conditions lend themselves to specific treatments.The ULTRA-stroke program is registered at the Netherlands Trial Register (NTR, http://www.trialregister.nl, number NTR1665) (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2965324 Fri, 06 Nov 2009 00:00:00 +0100 2965324 http://www.medworm.com/index.php?rid=2918149&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F56 Conclusions: In this NMO case report we wanted to emphasize the extensiveness of inflammatory spinal cord changes in our patient, from C2 level to conus. In the conclusion it is important to say that accurate, early diagnosis and distinction from MS is critical to facilitate initiation of immunosuppressive therapy for attack prevention. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2918149 Thu, 22 Oct 2009 23:00:00 +0100 2918149 http://www.medworm.com/index.php?rid=2884584&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F53 Conclusions: Currently there is no robust evidence to support recommendations on pharmacological treatments in patients with FXS in general or in those with an additional diagnosis of ADHD or autism. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2884584 Mon, 12 Oct 2009 23:00:00 +0100 2884584 http://www.medworm.com/index.php?rid=2884583&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F54 Background: Neutralizing antibodies (NAbs) against Interferon beta (IFNbeta) are reported to be associated with poor clinical response to therapy in multiple sclerosis (MS) patients. We aimed to quantify the contribution of NAbs to the sub-optimal response of IFNbeta treatment. Methods: We studied the prevalence of NAbs in MS patients grouped according to their clinical response to IFNbeta during the treatment period. Patients were classified as: group A, developing [greater than or equal to]1 relapse after the first 6 months of therapy; group B, exhibiting confirmed disability progression after the first 6 months of therapy, with or without superimposed relapses; group C, presenting a stable disease course during therapy. A cytopathic effect assay tested the presence of NAbs in a cohort o... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2884583 Mon, 12 Oct 2009 23:00:00 +0100 2884583 http://www.medworm.com/index.php?rid=2873904&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F51 Background: Bacterial meningitis is often associated with cerebral compromise which may be responsible for neurological sequelae in nearly half of the survivors. Little is known about the mechanisms of CNS involvement in bacterial meningitis. Several studies have provided substantial evidence for the key role of nitric oxide (NO) and reactive oxygen species in the complex pathophysiology of bacterial meningitis. Methods: In the present study, serum and CSF levels of NO, lipid peroxide (LPO) (mediators for oxidative stress and lipid peroxidation); total thiol, superoxide dismutase (SOD) (antioxidant mediators) and S-100B protein (mediator of astrocytes activation and injury), were investigated in children with bacterial meningitis (n=40). Albumin ratio (CSF/ serum) is a marker of blood-CSF ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2873904 Wed, 07 Oct 2009 23:00:00 +0100 2873904 http://www.medworm.com/index.php?rid=2826405&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F50 Conclusion: Sudden onset of upper limbs dysmetria is a sign of dysfunction in cerebellum and its associated pathway. However, lesion in spinal cord can also cause cerebellar signs such as dysmetria. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2826405 Wed, 23 Sep 2009 23:00:00 +0100 2826405 http://www.medworm.com/index.php?rid=2771123&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F49 Conclusions: Identification of stroke survivors at risk of high levels of participation restriction, depressive symptoms and low self-esteem will assist health professionals to devise appropriate rehabilitation interventions that target improving both physical and psychosocial functioning. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2771123 Sun, 06 Sep 2009 23:00:00 +0100 2771123 http://www.medworm.com/index.php?rid=2732280&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F48 Conclusions: Cognitive assessment is a basic element for dementia diagnosis. Age- and education-specific norms are required for this purpose, while the effect of gender can probably be ignored. The basis of cultural effects is poorly understood, but our findings serve to emphasise that normative data may not be safely generalised from one population to another with quite different characteristics. The minimal effects of region on COGSCORE and WLR are reassuring with respect to the cross-cultural validity of the 10/66 dementia diagnosis, which uses only these elements of the 10/66 battery. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2732280 Tue, 25 Aug 2009 23:00:00 +0100 2732280 http://www.medworm.com/index.php?rid=2732281&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F47 DiscussionOutcome model variables such as quality of life (QoL) or health care resource utilization require the patient to appraise their own well-being or third parties to set preferences. In Alzheimer's disease and other dementias the evaluation process performed by the patient is subject to the disease process itself because over progress of the disease neuroanatomical structures are affected that mediate evaluation processes.SummaryPublished research and methodological considerations thus lead to the conclusion that current QoL-instruments, which have been useful in other contexts, are ill-suited and insufficiently validated to play a major role in dementia research, decision making and resource allocation. New models integrating biomedical and outcome variables need to be developed in... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2732281 Mon, 24 Aug 2009 23:00:00 +0100 2732281 http://www.medworm.com/index.php?rid=2728446&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F46 Conclusions: Although no active hit has been identified, the present study demonstrates the feasibility of using a cell-based approach to HTS for FRDA. Furthermore, it highlights the difficulty in the development of a stable frataxin-deficient cell model, an essential condition for productive HTS in the future. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2728446 Sun, 23 Aug 2009 23:00:00 +0100 2728446 http://www.medworm.com/index.php?rid=2726319&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F45 DiscussionThis trial is distinctive in its aims in that it aids adjustment to MS in a broad sense. It is not a treatment specifically for depression. Use of nurses as therapists makes the interventions potentially viable in terms of being rolled out in the NHS. The trial benefits from incorporating patient input in the development and evaluation stages. The trial will provide important information about the efficacy, cost-effectiveness and acceptability of the interventions as well as mechanisms of psychosocial adjustment.Trial registration: Current Controlled Trials ISRCTN91377356 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2726319 Sat, 22 Aug 2009 23:00:00 +0100 2726319 http://www.medworm.com/index.php?rid=2742864&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F44 Background: No large study has compared the yield of diffusion-weighted imaging (DWI) with clinical examination in order to differentiate lacunar stroke from other stroke subtypes. This differentiation is important for guiding further investigations and treatment. Methods: Consecutive patients admitted with cerebral infarction were classified according to the Oxfordshire Community Stroke Project scale. Based on DWI and CT stroke was classified as lacunar (LI) and non-lacunar (NLI). Acute ischemic lesion (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2742864 Mon, 17 Aug 2009 23:00:00 +0100 2742864 http://www.medworm.com/index.php?rid=2710721&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F44 Background: No large study has compared the yield of diffusion-weighted imaging (DWI) with clinical examination in order to differentiate lacunar stroke from other stroke subtypes. This differentiation is important for guiding further investigations and treatment. Methods: Consecutive patients admitted with cerebral infarction were classified according to the Oxfordshire Community Stroke Project scale. Based on DWI and CT stroke was classified as lacunar (LI) and non-lacunar (NLI). Acute ischemic lesion (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2710721 Mon, 17 Aug 2009 23:00:00 +0100 2710721 http://www.medworm.com/index.php?rid=2693632&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F43 This study is registered in the Dutch Trial Register as NTR1534. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2693632 Wed, 12 Aug 2009 23:00:00 +0100 2693632 http://www.medworm.com/index.php?rid=2693634&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F41 Conclusion: The high specificity of FDG-PET suggests this technique might help in the diagnosis of frontotemporal dementia and other forms of early-onset dementia. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2693634 Tue, 11 Aug 2009 23:00:00 +0100 2693634 http://www.medworm.com/index.php?rid=2693633&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F42 This study may contribute to a new approach to prevent and treat fall risk in seniors in early stages of dementia.Trial Registration: The protocol for this study is registered with the Clinical Trials Registry, identifier number: NCT00934531 (www.clinicaltrials.gov) (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2693633 Tue, 11 Aug 2009 23:00:00 +0100 2693633 http://www.medworm.com/index.php?rid=2684707&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F40 Conclusions: Alleles of these 5 functional polymorphisms of MMPs seem not to be associated with structural alterations in the blood vessel wall of sCAD patients. However, this does not exclude a pathogenetic role for MMPs in sCAD via secondary factors such as cytokines that are able to induce these enzymes in cervical blood vessel walls. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2684707 Sat, 08 Aug 2009 23:00:00 +0100 2684707 http://www.medworm.com/index.php?rid=2643205&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F39 Conclusion: We described typical cases of a rare diseases, hemifacial atrophy and "en coup de sabre" scleroderma. In the patient diagnosed with Parry-Romberg syndrome, with Borrelia burgdoferi infection and with minor neurological symptoms, despite a four-year case history, there was a lack of proper diagnosis and treatment.In the second patient only skin changes without any neurological symptoms could be observed and only a precise neurological diagnosis revealed the presence of CNS tumor. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2643205 Sun, 26 Jul 2009 23:00:00 +0100 2643205 http://www.medworm.com/index.php?rid=2628429&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F36 DiscussionTo address the deficiencies of the existing studies, we propose a prospective cohort study nested within the International Carotid Stenting Study (ICSS), an international multi-centre trial in which over 1,700 patients have been randomised between stenting and CEA. In this cohort we will enrol a minimum of 300 patients treated with a stent. All patients undergo regular DUS examination at the yearly follow-up visit according to the ICSS protocol. To avoid verification bias, an additional computed tomography angiography (CTA) will be performed as a reference test in all consecutive patients, regardless the degree of stenosis on the initial DUS test. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2628429 Tue, 21 Jul 2009 23:00:00 +0100 2628429 http://www.medworm.com/index.php?rid=2628428&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F37 Conclusions: Our study shows no major gene effect of either the MTHFR or GSTO-1 genes as a modifier of ischemic stroke volume. However, given the relatively small sample size, a minor gene effect is not excluded by this investigation. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2628428 Tue, 21 Jul 2009 23:00:00 +0100 2628428 http://www.medworm.com/index.php?rid=2628427&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F38 This study aims to establish and evaluate community-based sustainable exercise programs for stroke survivors. We will determine the effects of the exercise programs in preventing falls and enhancing mobility among people following stroke. This program, if found to be effective, has the potential to be implemented within existing community services.Trial registration: The protocol for this study is registered with the Australian New Zealand Clinical Trials Registry ACTRN12606000479505. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2628427 Tue, 21 Jul 2009 23:00:00 +0100 2628427 http://www.medworm.com/index.php?rid=2604168&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F33 Background: Although chemotherapy with procarbazine, lomustine and vincristine (PCV) is considered to be well tolerated, side effects frequently lead to dose reduction or even discontinuation of treatment of oligodenrdroglial brain tumors. Methods: The primary objective of the analysis was to retrospectively compare progression-free survival (PFS) after PCV vs. PC chemotherapy (without vincristine to avoid side effects). Patients were retrospectively identified from an database containing our patients between 1990 and 2003. For the selected cases, all histopathology reports were re-evaluated by a local neuropathologist. Based on the updated histology data, patients were included in the study if they had at least one histological diagnosis of an oligodendroglial tumor. Results: PFS after st... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2604168 Wed, 15 Jul 2009 23:00:00 +0100 2604168 http://www.medworm.com/index.php?rid=2604167&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F34 DiscussionData analysis will analyse change in each group, and the differences between groups. Sub group analysis may be performed if sufficient numbers are recruited.Trial registration number: ISRCTN77610415 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2604167 Wed, 15 Jul 2009 23:00:00 +0100 2604167 http://www.medworm.com/index.php?rid=2604169&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F32 Conclusions: NG2 and phosphacan were both present in the evolving astroglial scar and, therefore, might play an important role in the blockade of successful CNS regeneration. Neurocan and versican, however, were located at the lesion epicentre, associated with Schwann cell myelin on regenerating peripheral nerve fibres, a distribution that was unlikely to contribute to failed CNS axon regeneration. The present data points to the importance of such correlative investigations for demonstrating the clinical relevance of experimental data. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2604169 Tue, 14 Jul 2009 23:00:00 +0100 2604169 http://www.medworm.com/index.php?rid=2582346&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F30 Conclusions: Cardioembolism is the main cause of brain infarction in the territory of the ACA. Several clinical features are more frequent in stroke patients with ACA infarction than in patients with ischaemic stroke due to infarction in the MCA and PCA territories. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2582346 Wed, 08 Jul 2009 23:00:00 +0100 2582346 http://www.medworm.com/index.php?rid=2578645&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F29 Conclusions: In general, we did not detect an increased prevalence of the co-morbidities diabetes mellitus, arterial hypertension, migraine, other headache and obesity compared to the general population. There was an increased prevalence of psychiatric co-morbidity in patients with PPV. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2578645 Mon, 06 Jul 2009 23:00:00 +0100 2578645 http://www.medworm.com/index.php?rid=2599940&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2Fbmcneurol%2F Conclusion These observations suggest that B-lymphocytes are involved in CFS pathogenesis for a subset of patients. Benefit for all CFS symptoms, the delayed symptom relief following B-cell depletion, the kinetics of relapses, and the effect also from methotrexate treatment, provide suggestive evidence that B-cells play a significant role in the ongoing clinical features, and that CFS may be amenable to therapeutic interventions aimed at modifying B-cell number and function. More systematic investigations of this therapeutic strategy, and of its biological basis, are now needed. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2599940 Tue, 30 Jun 2009 23:00:00 +0100 2599940 http://www.medworm.com/index.php?rid=2558258&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F28 Conclusion These observations suggest that B-lymphocytes are involved in CFS pathogenesis for a subset of patients. Benefit for all CFS symptoms, the delayed symptom relief following B-cell depletion, the kinetics of relapses, and the effect also from methotrexate treatment, provide suggestive evidence that B-cells play a significant role in the ongoing clinical features, and that CFS may be amenable to therapeutic interventions aimed at modifying B-cell number and function. More systematic investigations of this therapeutic strategy, and of its biological basis, are now needed. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2558258 Tue, 30 Jun 2009 23:00:00 +0100 2558258 http://www.medworm.com/index.php?rid=2551473&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F27 Conclusion: The present study provides additional evidence that SPEM dysfunction is associated with schizotypic features that precede the onset of schizophrenia and is already observable in general population subjects that show these features. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2551473 Sun, 28 Jun 2009 23:00:00 +0100 2551473 http://www.medworm.com/index.php?rid=2480621&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F25 Conclusion: The pontine infarction may present as PMH or hemiplegia with more frequency of nonvertiginous dizziness, a progressive course and diabetes mellitus. MRI can confirm the infarct location on the basal pons at early stage after stroke onset. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2480621 Mon, 15 Jun 2009 04:00:00 +0100 2480621 http://www.medworm.com/index.php?rid=2480622&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F24 DiscussionThe study is designed to identify targets for rehabilitation-, social- and medical-intervention strategies that promote and maintain healthy ageing in people with cardiovascular and mental health conditions, two of the seven Australian national health priority areas. This will rectify the paucity of information internationally around optimal clinical practice and social policy in this area. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2480622 Fri, 12 Jun 2009 04:00:00 +0100 2480622 http://www.medworm.com/index.php?rid=2565623&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2Fbmcneurol%2F DiscussionThe study is designed to identify targets for rehabilitation-, social- and medical-intervention strategies that promote and maintain healthy ageing in people with cardiovascular and mental health conditions, two of the seven Australian national health priority areas. This will rectify the paucity of information internationally around optimal clinical practice and social policy in this area. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2565623 Thu, 11 Jun 2009 23:00:00 +0100 2565623 http://www.medworm.com/index.php?rid=2470864&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F23 Conclusions: The analysis indicates that dementia and concomitant medication are factors in PD associated with psychotic symptoms. Furthermore, different dopaminergic drugs showed markedly different associations with psychotic symptoms (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2470864 Wed, 10 Jun 2009 04:00:00 +0100 2470864 http://www.medworm.com/index.php?rid=2460873&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F22 Conclusions: The degree of nerve involvement in early Bell's palsy correlates positively with age and negatively with corticosteroid use. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2460873 Sun, 07 Jun 2009 04:00:00 +0100 2460873 http://www.medworm.com/index.php?rid=2438028&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F21 Background: S100B protein and Neuron Specific Enolase (NSE) can increase due to brain cell damage and/or increased permeability of the blood-brain-barrier. Elevation of these proteins has been shown after various neurological diseases with cognitive dysfunction. Delirium is characterized by temporal cognitive deficits and is an important risk factor for dementia. The aim of this study was to compare the level of S100B and NSE of patients before, during and after delirium with patients without delirium and investigate the possible associations with different subtypes of delirium. Methods: The study population were patients aged 65 years or more acutely admitted after hip fracture. Delirium was diagnosed by the Confusion Assessment Method and the subtype by Delirium Symptom interview. In max... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2438028 Wed, 27 May 2009 04:00:00 +0100 2438028 http://www.medworm.com/index.php?rid=2430025&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F20 Conclusion: This study is designed to identify potential neuromotor changes associated with manual therapy procedures directed to the appendicular skeleton, compare the relative effect of treatment speed on potential neuromotor effects of manual therapy procedures, and determine the behavioral relevance of potential neuromotor effects of manual therapy procedures. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2430025 Thu, 21 May 2009 04:00:00 +0100 2430025 http://www.medworm.com/index.php?rid=2408999&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F18 Conclusion: Admission CRP is associated with stroke severity and long-term mortality when measured at least 24 hours after onset. There is a crude association between high CRP and short-term functional outcome which is likely secondary to stroke severity. CRP is an independent predictor of long-term mortality after ischemic stroke. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2408999 Tue, 28 Apr 2009 04:00:00 +0100 2408999 http://www.medworm.com/index.php?rid=2356930&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F16 Conclusions: Aggressive interventions are mandated to reduce blood pressure and alleviate the high risk of stroke in hypertensive patients. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2356930 Wed, 22 Apr 2009 04:00:00 +0100 2356930 http://www.medworm.com/index.php?rid=2356928&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F17 Conclusions: Our results show that BPPV is still an under-recognized entity. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2356928 Wed, 22 Apr 2009 04:00:00 +0100 2356928 http://www.medworm.com/index.php?rid=2335321&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F15 Conclusion: Physicians when dealing with childhood strokes and characteristic deficits in adult population should consider Moyamoya disease. Key words Moyamoya, Stroke, Cerebrovascular (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2335321 Wed, 15 Apr 2009 04:00:00 +0100 2335321 http://www.medworm.com/index.php?rid=2335322&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F14 DiscussionThe results of the FLASSH project will inform falls prevention practice for stroke survivors. If the falls prevention program is shown to be effective, low cost strategies to prevent falls can be implemented for those at risk around the time of discharge from rehabilitation, thus improving safety and quality of life for stroke survivors. The two sub-studies will contribute to the overall understanding and management of falls risk in stroke survivors.Trial registrationThis trial is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN012607000398404). (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2335322 Tue, 31 Mar 2009 04:00:00 +0100 2335322 http://www.medworm.com/index.php?rid=2312263&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F13 Background: The determination of Intraepidermal Nerve Fiber Density (IENFD) in skin biopsy is a useful method for the evaluation of different types of peripheral neuropathies. To allow a dependable use of the method it is necessary to determine interobserver reliability. Previous studies dealing with this topic used limited suitable statistical methods. Methods: In the present study three observers determined the IENFD and estimated the staining quality of the basement membrane for an adequate quantity of 120 skin biopsies (stained with indirect immunofluorescence technique) from 68 patients. More adequate statistical methods like intraclass correlation coefficient and Bland Altman Plot were chosen to estimate interobserver reliability. Results: We found an unexpected significant differe... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2312263 Tue, 31 Mar 2009 04:00:00 +0100 2312263 http://www.medworm.com/index.php?rid=2312262&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F14 DiscussionThe results of the FLASSH project will inform falls prevention practice for stroke survivors. If the falls prevention program is shown to be effective, low cost strategies to prevent falls can be implemented for those at risk around the time of discharge from rehabilitation, thus improving safety and quality of life for stroke survivors. The two sub-studies will contribute to the overall understanding and management of falls risk in stroke survivors. Trial registration This trial is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN012607000398404). (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2312262 Tue, 31 Mar 2009 04:00:00 +0100 2312262 http://www.medworm.com/index.php?rid=2289831&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F12 Conclusions Although the results need to be further explored in larger samples, these results do point towards possible use of proxy respondents to assess patient perceived treatment change at the group level. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2289831 Wed, 25 Mar 2009 04:00:00 +0100 2289831 http://www.medworm.com/index.php?rid=2208615&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F10 DiscussionHere, we report the design and sampling participants, measurement tools, and characteristics of the AGE study. This cohort study will allow a detailed study of the longitudinal comprehensive data on health information of elderly Koreans, thereby contributing to policy formulation and planning of health, welfare management, and other social services in Korea. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2208615 Tue, 24 Feb 2009 05:00:00 +0100 2208615 http://www.medworm.com/index.php?rid=2208616&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F9 DiscussionApplication of the Cardiac Rehabilitation paradigm to patients with ischaemic stroke or TIA has not been explored despite the obvious overlap in aetiology. It is hoped the anticipated improvement in vascular risk factors and fitness resulting from such a programme will enhance health and social gain in this population. Trial Registration: Current Controlled Trials ISCTRN90272638 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2208616 Mon, 23 Feb 2009 05:00:00 +0100 2208616 http://www.medworm.com/index.php?rid=2176493&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F8 This study has obtained ethical approval from the relevant Human Research Ethics Committees.DiscussionBy improving stroke survivors' walking ability, it is likely also to improve their general wellbeing by promoting better health and greater community participation. Furthermore, if stroke survivors can reach a point where their walking and community participation is self-sustaining, this will reduce the burden of care on family and friends as well as the economic burden on the health system. Given the major demographic shift in developed nations involving significant growth in the aged population, this research will make an important evidence-based contribution to the promotion of healthy ageing. Trial Registration: This trial is registered with the Australian New Zealand Clinical Trials ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2176493 Wed, 11 Feb 2009 05:00:00 +0100 2176493 http://www.medworm.com/index.php?rid=2176495&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F6 Conclusions: From the few available studies suitable for indirect comparison, DLX shows comparable efficacy and tolerability to GBP and PGB in DPNP. Duloxetine provides an important treatment option for this disabling condition. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2176495 Tue, 10 Feb 2009 05:00:00 +0100 2176495 http://www.medworm.com/index.php?rid=2176494&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F7 Conclusions: The course of illness in the three domains was heterogeneous among the patients. We were not able to identify any clinically relevant correlates of this heterogeneity. As an aid we constructed three algorithms corresponding to the cognitive domains, which can be used to characterize patients initially, identify rapid decliners and follow the course of the disease. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2176494 Tue, 10 Feb 2009 05:00:00 +0100 2176494 http://www.medworm.com/index.php?rid=2140115&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F5 Conclusions: The ReDeGi is a viable epidemiological surveillance device that provides information about the clinical and demographic characteristics of patients diagnosed with dementia in a defined geographical area. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2140115 Wed, 28 Jan 2009 05:00:00 +0100 2140115 http://www.medworm.com/index.php?rid=2124126&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F4 DiscussionNo adequately powered studies have investigated exercise interventions aimed at reducing falls in people with Parkinson's disease. This trial will determine the effectiveness of the exercise intervention in reducing falls and its cost effectiveness. This pragmatic program, if found to be effective, has the potential to be implemented within existing community services. Trial registration The protocol for this study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12608000303347) (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2124126 Thu, 22 Jan 2009 05:00:00 +0100 2124126 http://www.medworm.com/index.php?rid=2099742&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F3 Conclusion: CAA prevalence in populations is consistently higher in the demented as compared to the non-demented. This supports a significant role for CAA in the pathogenesis of dementia. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2099742 Tue, 13 Jan 2009 05:00:00 +0100 2099742 http://www.medworm.com/index.php?rid=2085985&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F2 Conclusions: MVW-PCA is a potential multivariate method that without modeling assumptions generates high quality images, which illustrated similar regional changes compared to modeling methods such as reference Logan. In addition, MVW-PCA could be used as a new technique, applicable not only on dynamic human brain studies but also on dynamic cardiac studies when using PET. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2085985 Wed, 07 Jan 2009 05:00:00 +0100 2085985 http://www.medworm.com/index.php?rid=2082862&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F9%2F1 Conclusions: Successful recruitment, follow up and early data analysis suggest that risk sharing schemes should be able to deliver their objectives. However, important issues of analysis, and political and commercial conflicts of interest still need to be addressed. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2082862 Tue, 06 Jan 2009 05:00:00 +0100 2082862 http://www.medworm.com/index.php?rid=2058356&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F51 Conclusions: Age is the most important determinant of atrophic cerebral changes. However, high ICAC demonstrated age independent association with central atrophy. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2058356 Mon, 22 Dec 2008 05:00:00 +0100 2058356 http://www.medworm.com/index.php?rid=2058355&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F52 Conclusion: Posttransplant cerebrovascular complications have severe impact on outcome of the patients who received OLT. Older age and systemic infection may be the possible risk factors of in-hospital intracranial hemorrhage following OLT. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2058355 Mon, 22 Dec 2008 05:00:00 +0100 2058355 http://www.medworm.com/index.php?rid=2044620&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F48 Conclusions: We conclude that pathogenic MAPT mutations are rare in Northern Finland. However, the MAPT H2 allele may be associated with an increased risk for FTLD as well as for eoAD in Finnish population. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2044620 Wed, 17 Dec 2008 05:00:00 +0100 2044620 http://www.medworm.com/index.php?rid=2044619&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F49 Conclusions: EXPLICIT stroke is a 5 year translational research programme which main aim is to investigate the effects of early applied intensive intervention for regaining dexterity and to explore the underlying mechanisms that are involved in regaining upper limb function after stroke. EXPLICIT-stroke will provide an answer to the key question whether therapy induced improvements are due to either a reduction of basic motor impairment by neural repair i.e. restitution of function and/or the use of behavioural compensation strategies i.e. substitution of function. EXPLICIT is registered at the Netherlands Trial Register (NTR, www.trialregister.nl., TC 1424). (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2044619 Wed, 17 Dec 2008 05:00:00 +0100 2044619 http://www.medworm.com/index.php?rid=2044618&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F50 Conclusions: A significant proportion of the population is at high-risk for OSA. Our study shows that despite low BMI and favorable craniofacial anatomy sleep apnea is still a locally relevant disease. Given the local relevance of OSAS, it is important to increase awareness among general population but more importantly among physicians of the developing countries, like Pakistan, about common clinical features and pertinent risk factors and complications of OSAS. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2044618 Wed, 17 Dec 2008 05:00:00 +0100 2044618 http://www.medworm.com/index.php?rid=2037921&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F47 Conclusions: Our results further extend on the involvement of PINK1 mutations in recessive early-onset parkinsonism with clinical features similar to carriers of parkin mutations. KeywordsConsanguineous; parkin; Exon 4 deletion mapping; PINK1, Homozygous mutation, P419R, S419P. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2037921 Tue, 16 Dec 2008 05:00:00 +0100 2037921 http://www.medworm.com/index.php?rid=2031267&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F46 Conclusion: The Apple iPod-ShuffleTM and similar devices provide a cost effective and an innovative platform for integration of individual auditory cueing devices into clinical, social and home environments and are shown to have immediate effect on gait, with improvements in walking speed, stride length and freezing. It is evident that individual auditory cueing devices are of benefit to people with Parkinson's disease and the aim of this randomised controlled trial is to maximise the benefits by allowing the individual to use devices in both a clinical and social setting, with minimal disruption to their daily routine. Trial registration The protocol for this study is registered with the US NIH Clinical Trials Registry (NCT00727467). (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2031267 Thu, 11 Dec 2008 05:00:00 +0100 2031267 http://www.medworm.com/index.php?rid=2024702&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F45 In this study, we evaluated the levels of plasma brain natriuretic peptide in acute ischemic stroke patients with cardioembolic stroke or non-cardioembolic stroke, and assessed the prediction factors of plasma brain natriuretic peptide and whether we could differentiate between stroke subtypes on the basis of plasma brain natriuretic peptide concentrations in addition to patient's clinical variables. Methods: Our patient cohort consisted of 131 consecutive patients with acute cerebral infarction who were admitted to Kagawa University School of Medicine Hospital from January 1, 2005 to December 31, 2007. The mean age of patients (43 females, 88 males) was 69.6+/-10.1 years. Sixty-two patients had cardioembolic stroke; the remaining 69 patients had non-cardioembolic stroke (including athero... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=2024702 Thu, 11 Dec 2008 04:29:20 +0100 2024702 http://www.medworm.com/index.php?rid=1983565&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F44 Conclusion. During the attentional processing, changes in the high EEG spectrum (beta-2 and gamma) in MS patients exhibit physiological alterations that are not normally detected by spontaneous EEG analysis. The different spectral pattern between pathological and controls groups could represent specific changes for the RRMS patients, indicative of compensatory mechanisms or cortical excitatory states representative of some phases during the RRMS course that are not present in the BMS group. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1983565 Mon, 24 Nov 2008 05:00:00 +0100 1983565 http://www.medworm.com/index.php?rid=1950255&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F43 Conclusion: Compared to baseline no worsening in mood and psychosocial functions was found three years after electrode implantation. Moreover, patients can be assigned to four distinct psychosocial profiles that are relatively stable in the time course. Since these subtypes already exist preoperatively the extent of psychosocial support can be anticipatory adjusted to the patients' needs in order to enhance coping strategies and compliance. This would allow early detection and even prevention of potential psychiatric adverse events after surgery. Given adequate psychosocial support, these findings imply that patients with mild psychiatric disturbances should not be excluded from surgery. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1950255 Tue, 11 Nov 2008 05:00:00 +0100 1950255 http://www.medworm.com/index.php?rid=1945995&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F42 Conclusions: Presynaptic SPECT scanning has a higher predictive value for the clinical diagnosis than TCD. However, since the PPV of an abnormal TCD for parkinsonism with nigrostriatal degeneration is high, TCD might be used as screening tool, before ordering a presynaptic SPECT. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1945995 Sun, 09 Nov 2008 05:00:00 +0100 1945995 http://www.medworm.com/index.php?rid=1936958&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F41 Background: We previously demonstrated improved sweating after enzyme replacement therapy (ERT) in Fabry disease using the thermo-regularity sweat and quantitative sudomotor axon reflex tests. Skin-impedance, a measure skin-moisture (sweating), has been used in the clinical evaluation of burns and pressure ulcers using the portable dynamic dermal impedance monitor (DDIM) system. Methods: We compared skin impedance measurements in hemizygous patients with Fabry disease (22 post 3-years of bi-weekly ERT and 5 ERT naive) and 22 healthy controls. Force compensated skin-moisture values were used for statistical analysis. Outcome measures included 1) moisture reading of the 100th repetitive reading, 2) rate of change, 3) average of 60-110th reading and 4) overall average of all readings. Resul... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1936958 Thu, 06 Nov 2008 05:00:00 +0100 1936958 http://www.medworm.com/index.php?rid=1917029&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F40 Background: The treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major unsolved problem in Neurology. Current gold standard for therapy is acyclovir, a drug that inhibits viral replication. Despite antiviral treatment, mortality remains up to 15%, less than 20% of patients are able to go back to work, and the majority of patients suffer from severe disability. This is a discouraging, unsatisfactory situation for treating physicians, the disabled patients and their families, and constitutes an enormous burden to the public health services. The information obtained from experimental animal research and from recent retrospective clinical observations, indicates that a substantial benefit in outcome can be expected in patients with HSVE who are treated with adjuvant dexamethason... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1917029 Wed, 29 Oct 2008 04:00:00 +0100 1917029 http://www.medworm.com/index.php?rid=1878315&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F39 Conclusions: Greater age, female sex, stroke and depression increase the risk of suffering dementia, AD and VD. The relationship between depression, vascular risk factors and dementia has clear public health implications. Prevention and early treatment of vascular risk factors and depression may have an important impact in lowering the risk of dementia and could modify the natural history of the disease.Keywordsdementia, risk factors, Alzheimer's disease, vascular dementia (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1878315 Wed, 15 Oct 2008 04:00:00 +0100 1878315 http://www.medworm.com/index.php?rid=1864538&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F38 Conclusions: Together these studies indicate that the 29G/5-bevel needle with the TPE shield is an improvement over the 27G/3-bevel needle with standard rubber shield in terms of pain, ease of insertion and patient satisfaction. These improvements are expected to result in improved compliance in patients with MS treated with IFN beta-1a, 44 or 22 mcg sc tiw. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1864538 Fri, 10 Oct 2008 04:00:00 +0100 1864538 http://www.medworm.com/index.php?rid=1854986&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F37 Conclusions: The present investigation shows that symptom validity testing as implemented in the BSV-STM is one clinically useful element in the detection of memory malingering. However, clinicians have to be aware that coaching influences performance in the test. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1854986 Tue, 07 Oct 2008 04:00:00 +0100 1854986 http://www.medworm.com/index.php?rid=1836107&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F36 Conclusions: Despite the large proportion of individuals with mild disease severity in our sample, a considerable number of needs were identified of which many, on an individual level, varied over time. Key services demanded by PwMS were identified. Also the level of satisfaction with care varied and areas with a potential for improvement were identified such as the availability of rehabilitation services including an increase in the supply of psychosocial support and counselling. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1836107 Mon, 29 Sep 2008 04:00:00 +0100 1836107 http://www.medworm.com/index.php?rid=1828289&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F35 Conclusion: Modality-specific selective attention results in behavioral decrements in unattended sensory modalities. The imaging results presented here provide a neural signature (cross-modal deactivation) for modality-specific selective attention. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1828289 Thu, 25 Sep 2008 04:00:00 +0100 1828289 http://www.medworm.com/index.php?rid=1810835&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F34 Conclusions: Rivastigmine is safe in stroke patients with delirium even after rapid titration. In the majority of patients the delirium improved after treatment. A randomized controlled trial is needed to establish the usefulness of rivastigmine in delirium after stroke. Trial registration: Nederlands Trial Register NTR1395 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1810835 Sat, 20 Sep 2008 04:00:00 +0100 1810835 http://www.medworm.com/index.php?rid=1796607&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F33 Conclusions: Pregabalin 600 mg/d (300 mg BID) effectively reduced pain, was well tolerated, and had no statistically significant or clinically meaningful effect on NC in patients with painful DPN. Trial registration: ClinicalTrials.gov NCT00159679 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1796607 Tue, 16 Sep 2008 04:00:00 +0100 1796607 http://www.medworm.com/index.php?rid=1737582&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F32 Conclusion: Our reported increase in the minimal disease region should inform other researchers that the chromosome 9 locus may be more telomeric than predicted by published recombination boundaries. Moreover, the existence of a family member with clinical Alzheimer's disease, and who shares the disease haplotype, highlights the possibility that late-onset AD patients in the other linked pedigrees may be mis-classified as sporadic dementia cases. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1737582 Fri, 29 Aug 2008 04:00:00 +0100 1737582 http://www.medworm.com/index.php?rid=1688012&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F31 Conclusion: The association of leukoaraiosis with large-artery disease in this study might be due to the relatively high prevalence of intracranial occlusive lesions in Korean stroke patients compared to other ethnic groups. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1688012 Thu, 07 Aug 2008 04:00:00 +0100 1688012 http://www.medworm.com/index.php?rid=1673495&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F29 Conclusions: Duloxetine is equally effective for the treatment of PDN and fibromyalgia, judged by the outcome of at least 50% pain relief over 12 weeks, and is well tolerated. The NNT of 6 for 50% pain relief suggests that this is likely to be a useful drug in these difficult-to-treat conditions, where typically only a minority of patients respond. Comparing duloxetine with antidepressants for pain relief in DPN shows inadequacies in the evidence for efficacy of antidepressants, which are currently recommended in PDN care pathways. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1673495 Fri, 01 Aug 2008 04:00:00 +0100 1673495 http://www.medworm.com/index.php?rid=1673494&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F30 Conclusions: Preterm birth does not appear to contribute to MS aetiology. Other factors involved in foetal and early development need to be explored to elucidate the mechanism of the increased risk conferred by the apparent maternal effect. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1673494 Fri, 01 Aug 2008 04:00:00 +0100 1673494 http://www.medworm.com/index.php?rid=1648047&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F28 Conclusions: Based on these findings, there are no principle obstacles to start limited and supervised oral feeding in stroke patients with a NGT in place. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1648047 Wed, 23 Jul 2008 04:00:00 +0100 1648047 http://www.medworm.com/index.php?rid=1641532&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F27 Background: Recent clinical studies point to rapid and sustained clinical, cognitive, and behavioral improvement in both Alzheimer's disease and primary progressive aphasia following weekly perispinal administration of etanercept, a TNF-alpha inhibitor that acts by blocking the binding of this cytokine to its receptors. This outcome is concordant with recent basic science studies suggesting that TNF-alpha functions in vivo as a gliotransmitter that regulates synaptic function in the brain. We hypothesized that perispinal etanercept had the potential to improve verbal function in Alzheimer's disease, so we included several standarized measures of verbal ability to evaluate language skills in a clinical trial of perispinal etanercept for Alzheimer's disease. Methods: This was a prospective, ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1641532 Mon, 21 Jul 2008 04:00:00 +0100 1641532 http://www.medworm.com/index.php?rid=1641533&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F26 Conclusion: This exploratory study found that homocysteine levels are not significantly elevated in Nigerians with acute ischaemic stroke, and admission Hcy level is not a determinant of short-term (4 week) stroke outcome. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1641533 Sat, 12 Jul 2008 04:00:00 +0100 1641533 http://www.medworm.com/index.php?rid=1613669&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F26 The objective of this study was to determine the prevalence and short-term impact of hyperhomocysteinemia in Nigerians with acute ischaemic stroke. We hypothesized that Hcy levels are significantly higher than in normal controls, worsen stroke severity, and increase short-term case fatality rates following acute ischaemic stroke. Methods: The study employed both a case-control and prospective follow-up design to study hospitalized adults with first - ever acute ischaemic stroke presenting within 48 hours of onset. Clinical histories, neurological evaluation (including National Institutes of Health Stroke Scale (NIHSS) scores on admission) were documented. Total plasma Hcy was determined on fasting samples drawn from controls and stroke cases (within 24 hours of hospitalization). Outcome a... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1613669 Sat, 12 Jul 2008 04:00:00 +0100 1613669 http://www.medworm.com/index.php?rid=1604525&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F25 Conclusion: Patients reported high medication persistence rates six and 12 months after stroke. Identification of factors associated with nonpersistence (such as older age and prior disability) will help predict which patients are at higher risk for discontinuing their medications. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1604525 Thu, 10 Jul 2008 04:00:00 +0100 1604525 http://www.medworm.com/index.php?rid=1545873&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F24 Conclusion: To ensure a better prognosis, CVA patients require ICU therapeutic interventions,. However, as we have shown, where tests can determine the worst affected patients with a poor vital and functional outcome should treatment be withheld? (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1545873 Thu, 26 Jun 2008 04:00:00 +0100 1545873 http://www.medworm.com/index.php?rid=1540576&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F23 Conclusions: Although carotid bruits are not accurate to confirm or to exclude significant carotid stenoses, these signs are appropriate for directed screening for further investigation with carotid US if the patient lacks contraindications for surgery. Lack of carotid bruits in CVD patients does not exclude a carotid stenosis. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1540576 Tue, 24 Jun 2008 04:00:00 +0100 1540576 http://www.medworm.com/index.php?rid=1533850&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F21 Conclusions: Using the UM-PDHQ, we were able to define the key characteristics of hallucinations in PD in our cohort. Future directions include the validation of the quantitative part of the questionnaire than will serve as a rating scale for severity of hallucinations. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1533850 Fri, 20 Jun 2008 04:00:00 +0100 1533850 http://www.medworm.com/index.php?rid=1533849&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F22 This study will evaluate a structured programme of exercises that can be delivered to people with stroke by their 'family members/friends'. Given that the progressive increase in the population of older people is likely to lead to an increased prevalence of stroke in the future, it is important to reduce the burden of this illness on the individual, the family and society. Family mediated exercises can maximise the carry over outside formal physiotherapy giving patients the opportunity for informal practice. Trial Registration The protocol for this study is registered with the US NIH Clinical trials registry (NCT00666744) (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1533849 Fri, 20 Jun 2008 04:00:00 +0100 1533849 http://www.medworm.com/index.php?rid=1521027&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F20 Conclusion: We conclude that, if chelating excessive mitochondrial iron may be beneficial at some stage of the disease, great attention should be paid to not fully deplete mitochondrial iron store in order to avoid undesirable consequences. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1521027 Mon, 16 Jun 2008 04:00:00 +0100 1521027 http://www.medworm.com/index.php?rid=1505653&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F19 Conclusions: The excellent reliability of many of the data elements supports the use of the PCNASR to monitor and improve care. However, the poor reliability for several variables, particularly time-related events in the emergency department, indicates the need for improved data collection methods. Specific recommendations include improvements to data definitions, abstractor training, and the development of ED-based real-time data collection systems. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1505653 Wed, 11 Jun 2008 04:00:00 +0100 1505653 http://www.medworm.com/index.php?rid=1476626&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F18 This study was designed to assess awareness of stroke warning signs in Nigerians at increased risk. Methods: A hospital-based cross-sectional study conducted at Irrua Specialist Teaching Hospital, in southern Nigeria. Patients with a diagnosis of hypertension, diabetes or both were interviewed for the warning signs of stroke in the outpatient clinic by trained interviewers. The main outcome measure was ability to identify at least one stroke warning sign. Results: There were 225 respondents with a mean age of 58.0+/-11.7 years. Only 39.6% could identify at least one stroke warning sign while the commonest sign identified was sudden unilateral limb weakness (24.4%). On multivariate logistic regression analysis, male sex (beta= 0.26, 95% CI=0.14-0.39, p (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1476626 Fri, 30 May 2008 04:00:00 +0100 1476626 http://www.medworm.com/index.php?rid=1451173&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F17 Background: Phase I/II placebo-controlled clinical trials of recombinant Factor VIIa (rFVIIa) suggested that administration of rFVIIa within 4 hours after onset of intracerebral hemorrhage (ICH) is safe, limits ICH growth, and improves outcomes. We sought to determine the cost-effectiveness of rFVIIa for acute ICH treatment, using published Phase II data. We hypothesized that rFVIIa would have a low marginal cost-effectiveness ratio (mCER) given the poor neurologic outcomes after ICH with conventional management. Methods: We performed an incremental cost-effectiveness analysis from the societal perspective, considering conventional management vs. 80 ug/kg rFVIIa treatment for acute ICH cases meeting Phase II inclusion criteria. The time frame for the analysis was 1.25 years: data from the ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1451173 Mon, 19 May 2008 04:00:00 +0100 1451173 http://www.medworm.com/index.php?rid=1444704&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F16 Conclusions: The combination of a latent growth model with a model for the missing data has permitted to make use of all available data and quantify the effect of significant predictors of dropout on the dropout and observational processes. Cognitive decline over time in older persons is often modelled as a linear process, though we have presented other parametric curves that may be considered. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1444704 Fri, 16 May 2008 04:00:00 +0100 1444704 http://www.medworm.com/index.php?rid=1438162&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F15 This descriptive, hospital-based study, performed in western Turkey, was designed to assess the level of pre-hospital delay and reasons for such delay in acute stroke patients, taking into consideration certain factors such as socioeconomic status, availability of transport options at onset of symptoms. Data were collected from hospital records, and a questionnaire was administered that included questions about socio-demographics, self-reported risk factors and questions related to hospital arrival. The rate of patients arriving at the hospital more than 3 hours after symptom onset was found to be 31.6% for this study. Approximately 1/3 of patients delayed going to the hospital because they were waiting for symptoms to go away while, 1/3 of patients were not aware of the importance of seek... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1438162 Tue, 13 May 2008 04:00:00 +0100 1438162 http://www.medworm.com/index.php?rid=1435567&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F14 Conclusion: These preliminary results suggest that utilization of the heat transfer capacity of the non-hairy skin surfaces can enable temperature-sensitive individuals with MS to extend participation in day-to-day physical activities despite thermally stressful conditions. However, systematic longitudinal studies in larger cohorts of MS patients with specific deficits and levels of disability conducted under a variety of test conditions are needed to confirm these preliminary findings. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1435567 Mon, 12 May 2008 04:00:00 +0100 1435567 http://www.medworm.com/index.php?rid=1424977&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F13 Conclusions: These findings indicate parallel development to normalization of swallowing related cortical activation and clinical recovery from dysphagia and highlight the importance of the insula and the PPC for the central coordination of swallowing. The results suggest that MEG examination of swallowing can reflect short-term changes in patients suffering from neurogenic dysphagia. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1424977 Wed, 07 May 2008 04:00:00 +0100 1424977 http://www.medworm.com/index.php?rid=1390085&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F12 Conclusions: In individuals free from a history of stroke or dementia, high subclinical cerebrovascular disease burden was associated with worse cognitive function in multiple domains. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1390085 Tue, 22 Apr 2008 04:00:00 +0100 1390085 http://www.medworm.com/index.php?rid=1387919&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F11 Conclusion: Patients with RRMS treated with IFN beta-1a, 44 mcg sc tiw, had greater reduction in T2 BOD after 48 weeks than those treated with IFN beta-1a, 30 mcg im qw, which is consistent with other clinical and MRI outcome measures in the EVIDENCE study. In patients testing positive for NAbs (NAb+) to IFN beta-1a 44 mcg sc tiw, changes in BOD were smaller than in NAb negative (NAb-) patients, but similar to those receiving IFN beta-1a, 30 mcg im qw. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1387919 Mon, 21 Apr 2008 04:00:00 +0100 1387919 http://www.medworm.com/index.php?rid=1380172&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F10 Conclusions: The present study showed that pooled NIA and PsA patients had a different pattern in lower limb descriptive actometry than other patients in a non-selected sample. Careful questioning of patients is a useful method of diagnosing NIA in a clinical setting. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1380172 Fri, 18 Apr 2008 04:00:00 +0100 1380172 http://www.medworm.com/index.php?rid=1374555&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F8 Conclusions: Systematic changes in thalamic shape can be non-invasively assessed in PD in vivo. Shape changes, in addition to volume changes, may represent a new avenue to assess the progress of neurodegenerative processes. Although not directly discernable at the resolution of standard MRI, previous pathological studies would suggest that the shape changes detected in this study represent degeneration in the centre median-parafascicular (CM-Pf) complex, an area known to represent selective non-dopaminergic degeneration in PD. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1374555 Wed, 16 Apr 2008 04:00:00 +0100 1374555 http://www.medworm.com/index.php?rid=1365750&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F7 This study aims to evaluate a new therapy for improving arm function in sub-acute stroke patients based on mental practice theories and functional task-oriented training, and to study the predictors for a positive treatment result. It is hypothesized that a six-week, mental practice-based training program (additional to regular therapy) targeting the specific upper extremity skills important to the individual patient will significantly improve both arm function and daily activity performance, as well as being cost effective. Methods/design: One hundred and sixty sub-acute stroke patients with upper limb paresis (MRC grade 1-3) will participate in a single-blinded, multi-centre RCT. The experimental group will undertake a six-week, individually tailored therapy regime focused on improving ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1365750 Fri, 11 Apr 2008 04:00:00 +0100 1365750 http://www.medworm.com/index.php?rid=1330734&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F5 Conclusions: This prospective community-based study shows one of the lowest incidences of stroke in Europe, as well as one of the lowest case fatality and disability rates at 90 days after stroke. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1330734 Thu, 27 Mar 2008 04:00:00 +0100 1330734 http://www.medworm.com/index.php?rid=1328271&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F4 Conclusions: In our sample there is no association between ACE genotype or allele frequency and migraine. In addition, ACE genotype in our experience did not predict the clinical response to lisinopril or candesartan used as migraine prophylactics. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1328271 Wed, 26 Mar 2008 04:00:00 +0100 1328271 http://www.medworm.com/index.php?rid=1282964&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F3 Background: A software based tool has been developed (Optem) to allow automatize the recommendations of the Canadian Multiple Sclerosis Working Group for optimizing MS treatment in order to avoid subjective interpretation. Methods: Treatment Optimization Recommendations (TOR) were applied to our database of patients treated with IFN B1a IM. Patient data were assessed during year 1 for disease activity and patients assigned to 2 groups according to TOR: " change treatment " (C) and " no change treatment " (N). These assessments were then compared to observed clinical outcomes for disease activity over the following years. Results: We have data on 55 patients. The " change treatment " status was assigned to 22 patients, and " no change treatment " to 33 patients. The estimated sensitivity a... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1282964 Thu, 06 Mar 2008 05:00:00 +0100 1282964 http://www.medworm.com/index.php?rid=1264312&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F2 Background The use of self-report measurements in clinical settings is increasing. However, in patients with limitations that interfere with reliable self-assessment such as cognitive impairment or mood disturbances, as may be the case in multiple sclerosis (MS), data collection might be problematic. In these situations, information obtained from proxy respondents (e.g. partners) may replace self-ratings. The aim of this study was to examine the value of proxy ratings at separate points in time and to assess patient-proxy agreement on possible changes in disease impact of MS. Methods Fifty-six MS patients and their partners completed the Multiple Sclerosis Impact Scale (MSIS-29) at baseline and follow-up, two years later. Patient-proxy agreement was assessed at both time points by calculat... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1264312 Thu, 28 Feb 2008 05:00:00 +0100 1264312 http://www.medworm.com/index.php?rid=1168234&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F8%2F1 Conclusions: Mutations are common in Portuguese patients with Parkinson's disease, and these results clearly have implications not only for the genetic diagnosis, but also for the genetic counseling of these patients. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1168234 Tue, 22 Jan 2008 05:00:00 +0100 1168234 http://www.medworm.com/index.php?rid=1071736&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F40 Conclusion: People with CFS reported sleep problems significantly more often than control subjects. Yet, when measured these parameters and sleep architecture did not differ between the two subject groups. A unique finding requiring further study is that control, but not CFS subjects, significantly over reported sleep latency suggesting CFS subjects may have an increased appreciation of sleep behaviour that may contribute to their perceived sleep problems. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1071736 Wed, 05 Dec 2007 05:00:00 +0100 1071736 http://www.medworm.com/index.php?rid=1014157&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F39 The objective of the Locomotor Experience Applied Post-Stroke (LEAPS) trial is to determine if there is a difference in the proportion of participants who recover walking ability at one year post-stroke when randomized to a specialized locomotor training program (LTP), conducted at 2- or 6-months post-stroke, or those randomized to a home based non-specific, low intensity exercise intervention (HEP) provided 2 months post-stroke. We will determine if the timing of LTP delivery affects gait speed at 1 year and whether initial impairment severity interacts with the timing of LTP. The effect of number of treatment sessions will be determined by changes in gait speed taken pre-treatment andpost-12, -24, and -36 sessions. Methods: We will recruit 400 adults with moderate or severe walking limit... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1014157 Thu, 08 Nov 2007 05:00:00 +0100 1014157 http://www.medworm.com/index.php?rid=1004323&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F38 Conclusions: This exploratory study has shown altered activities of the enzyme carnosinase in patients with dementia. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=1004323 Mon, 05 Nov 2007 05:00:00 +0100 1004323 http://www.medworm.com/index.php?rid=978146&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F37 Conclusions: This study provides the first evidence that neuroserpin is associated with early-onset ischemic stroke among Caucasian women. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=978146 Thu, 25 Oct 2007 04:00:00 +0100 978146 http://www.medworm.com/index.php?rid=960779&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F36 Background: The presence of antiphospholipid antibodies (APLA) in multiple sclerosis (MS) patients has been reported frequently but no clear relationship between APLA and the clinical and neuroimaging features of MS have heretofore been shown. We assessed the clinical and neuroimaging features of MS patients with plasma APLA. Methods: A consecutive cohort of 24 subjects with relapsing-remitting (RR) MS were studied of whom 7 were in remission (Rem) and 17 in exacerbation (Exc). All subjects were examined and underwent MRI of brain. Patients' plasma was tested by standard ELISA for the presence of both IgM and IgG antibodies using a panel of 6 targets: cardiolipin (CL), beta2 glycoprotein I (beta2GPI), Factor VII/VIIa (FVIIa), phosphatidyl choline (PC), phosphatidyl serine (PS) and phospha... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=960779 Thu, 18 Oct 2007 04:00:00 +0100 960779 http://www.medworm.com/index.php?rid=953493&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F35 Conclusions: CML staining in cortical neurons and cerebral vessels is related to the severity of cognitive impairment in people with cerebrovascular disease and only minimal Alzheimer pathology. These findings support the possibility that cerebral accumulation of AGEs may contribute to dementia in people with cerebrovascular disease. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=953493 Tue, 16 Oct 2007 04:00:00 +0100 953493 http://www.medworm.com/index.php?rid=951455&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F33 Background: Interruption of flow through of cerebral blood vessels results in acute ischemic stroke. Subsequent breakdown of the blood brain barrier increases cerebral injury by the development of vasogenic edema and secondary hemorrhage known as hemorrhagic transformation (HT). Diabetes is a risk factor for stroke as well as poor outcome of stroke. The current study tested the hypothesis that diabetes-induced changes in the cerebral vasculature increase the risk of HT and augment ischemic injury. Methods: Diabetic Goto-Kakizaki (GK) or control rats underwent 3 hours of middle cerebral artery occlusion and 24 h reperfusion followed by evaluation of infarct size, hemorrhage and neurological outcome. Results: Infarct size was significantly smaller in GK rats (8 +/- 4 vs 29+/- 5%, p (Source: ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=951455 Mon, 15 Oct 2007 04:00:00 +0100 951455 http://www.medworm.com/index.php?rid=951454&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F34 The objective is to investigate the therapeutic potential of mental practice embedded in daily therapy to improve individually chosen daily activities of adult stroke patients compared to therapy as usual. In addition, we will investigate prognostic variables and feasibility (process evaluation). Methods: A randomised, controlled, observer masked prospective trial will be conducted with adult stroke patients in the (sub)acute phase of stroke recovery. Over a six weeks intervention period the control group will receive multi professional therapy as usual. Patients in the experimental group will be instructed how to perform mental practice, and will receive care as usual in which mental practice is embedded in physical, occupation and speech therapy sessions. Outcome will be assessed at six ... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=951454 Mon, 15 Oct 2007 04:00:00 +0100 951454 http://www.medworm.com/index.php?rid=937926&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F32 Conclusions: One in 8 patients with acute intracerebral haemorrhage had a thalamic hematoma. Altered consciousness, intraventricular extension of the hematoma and advanced age were determinants of a poor early outcome. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=937926 Fri, 05 Oct 2007 04:00:00 +0100 937926 http://www.medworm.com/index.php?rid=881103&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F31 Conclusions: Our data indicate that MS patients in stable condition and with social support can hope to have better QOL, if clinicians pay attention to depression, disability, the impact of side effects of treatment and family caregiver anxieties about the illness. The findings call for a regular program of psychosocial intervention in the clinical setting, to address these issues and provide caregiver education and supports, in order to enhance the quality of care. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=881103 Tue, 18 Sep 2007 04:00:00 +0100 881103 http://www.medworm.com/index.php?rid=847926&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F30 Conclusions: Cells of the ependymal region play an important role in CSF homeostasis, cellular signaling and wound repair in the spinal cord. The possible effects of this ascending pathology on ependymal function are discussed. Our studies suggest central canal dilation and ependymal region disruption as steps in the pathogenesis of chronic SCI, identify central canal dilation as a marker of chronic SCI and provide novel targets for therapeutic intervention. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=847926 Fri, 07 Sep 2007 04:00:00 +0100 847926 http://www.medworm.com/index.php?rid=845124&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F29 DiscussionGiven that the Australian population is ageing and people after stroke can expect to live for longer, attainment of safe, independent walking is more likely to be associated with long-term health and well being. In its National Research Priorities, the Government has recognised that it will be important to promote healthy ageing and that this endeavour will be underpinned by research. The results of this study will clearly identify effective intervention to establish early quality walking, thereby promoting an increase in community participation in the longer term. Trial Registration The protocol for this study is registered with US NIH Clinical trials registry (NCT00167531). (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=845124 Thu, 06 Sep 2007 04:00:00 +0100 845124 http://www.medworm.com/index.php?rid=838442&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F28 DiscussionAs this prospective trial enrols only patients with an early-stage parkinsonism, it will yield data on the diagnostic accuracy of TCD that is relevant to daily clinical practice: The neurologist needs a diagnostic tool that provides additional information in patients with a clinically indefinable parkinsonian syndrome. The above described observational longitudinal study was designed to explicitly study this aspect in the diagnostic process. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=838442 Tue, 04 Sep 2007 04:00:00 +0100 838442 http://www.medworm.com/index.php?rid=836286&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F27 Conclusions: SPECT with presynaptic radiotracers is relatively accurate to differentiate patients with PD in an early phase from normalcy, patients with PD from those with ET, and PD from VP. The accuracy of SPECT with both presynaptic and postsynaptic tracers to differentiate between PD and APS is relatively low. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=836286 Sat, 01 Sep 2007 04:00:00 +0100 836286 http://www.medworm.com/index.php?rid=831753&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F26 Conclusions: The ADAS-Cog did not capture all clinically important effects. In general, ADAS-Cog improvement indicates clinical improvement, whereas many people with ADAS-Cog decline do not show clinical decline. The open-label design of this study does not allow us to know whether this is a treatment effect, which requires further investigation. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=831753 Thu, 30 Aug 2007 04:00:00 +0100 831753 http://www.medworm.com/index.php?rid=829199&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F25 Conclusions: The results of the present experiment show that in the lack of vision and somatosensory information, vestibular signal processing allows the maintenance of an active sitting posture (i.e. without back or side rests). When head orientation changes with respect to the trunk, in the absence of vision, the lack of cervical information prevents the transformation of the head-centered vestibular information into a trunk-centered frame of reference of body motion. For the normal subjects, this latter frame of reference enables proper postural adjustments through vestibular signal processing, irrespectively of the orientation of the head with respect to the trunk. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=829199 Wed, 29 Aug 2007 04:00:00 +0100 829199 http://www.medworm.com/index.php?rid=787506&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F24 Conclusions: We found an high prevalence of extrapyramidal symptoms in a group of male dental technicians working in a state technical high school in Rome. We believe that this finding could be due to the presence of toxins in the dental technician's work. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=787506 Wed, 08 Aug 2007 04:00:00 +0100 787506 http://www.medworm.com/index.php?rid=784856&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F23 Conclusions: It is hypothesized that TTH patients have different stress adaptive mechanisms than controls and migraineurs, involving delayed cardiovascular adaptation and reduced pain control system inhibition. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=784856 Tue, 07 Aug 2007 04:00:00 +0100 784856 http://www.medworm.com/index.php?rid=780568&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F22 Conclusion: The results indicated that an unexpected high incidence of Guillain-Barre syndrome has occurred in 2003 in the region. We concluded that a monitoring and surveillance system for Guillain-Barre syndrome is essential to set up in this region. Key words: Guillain-barre syndrome, Epidemiology, Incidence, Iran. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=780568 Sun, 05 Aug 2007 04:00:00 +0100 780568 http://www.medworm.com/index.php?rid=775809&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F21 Conclusions: CHEPS appears a sensitive measure, with abnormalities observed in some symptomatic patients who did not have significant IEF loss and/or QST abnormalities. Some of the latter patients may have early small fibre dysfunction or ion channelopathy. CHEPS provides a clinically practical, non-invasive and objective measure, and can be a useful additional tool for the assessment of sensory small fibre neuropathy. Although further evaluation is required, the technique shows potential clinical utility to differentiate neuropathy from other chronic pain states, and provide a biomarker for analgesic development. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=775809 Fri, 03 Aug 2007 04:00:00 +0100 775809 http://www.medworm.com/index.php?rid=736979&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F20 Conclusions: Timing adherence, but not motor scores, improves by providing patients with extra information. Therapy timing is of potential importance in Parkinson's disease management. Trial registration number: NCT00361205 (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=736979 Mon, 16 Jul 2007 04:00:00 +0100 736979 http://www.medworm.com/index.php?rid=720874&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F19 Conclusions: The two novel mutations in the connexin32 gene are more severe than the majority of previously described mutations possibly due to the severe structural change of the gap junction they encode. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=720874 Mon, 09 Jul 2007 04:00:00 +0100 720874 http://www.medworm.com/index.php?rid=700235&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F18 Conclusions: A careful analysis of this case and a review of the relevant literature indicate that the clinical residua after recovery from hypoxic injury to the brain is predominantly disorders of the motor system, and the MRI manifestations as well as the clinical presentation can evolve over time. Understanding more of the factors that affect hypoxic brain injury can be helpful in determining the clinical outcome and management of these patients. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=700235 Wed, 27 Jun 2007 04:00:00 +0100 700235 http://www.medworm.com/index.php?rid=696022&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F17 Conclusions: The involvement of MMP-1, -2, -9 and -12 has been demonstrated in the post-traumatic events after human SCI. With an expression pattern corresponding largely to prior experimental studies, they were mainly expressed during the first weeks after injury and were most likely involved in the destructive inflammatory events of protein breakdown and phagocytosis carried out by infiltrating neutrophils and macrophages, as well as being involved in enhanced permeability of the blood spinal cord barrier. Similar to animal investigations, the strong induction of MMPs was not accompanied by an expression of their inhibitors, allowing these proteins to exert their effects in the lesioned spinal cord. (Source: BMC Neurology) BMC Neurology journals http://www.medworm.com/rss/comments.php?id=696022 Tue, 26 Jun 2007 04:00:00 +0100 696022 http://www.medworm.com/index.php?rid=692539&cid=s_32213_25_f&fid=32213&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F7%2F16 Background: MRI negative PET positive temporal lobe epilepsy represents a substantial minority of temporal lobe epilepsy (TLE). Clinicopathological and qualitative imaging differences from mesial temporal lobe epilepsy are reported. We aimed to compare TLE with hippocampal sclerosis (HS+ve) and non lesional TLE without HS (HS-ve) on MRI, with respect to quantitative FDG-PET and MRI measures. Methods: 30 consecutive HS-ve patients with well-lateralised EEG were compared with 30 age- and sex-matched HS+ve patients with well-lateralised EEG. Cerebral, cortical lobar and hippocampal volumetric and co-registered FDG-PET metabolic analyses were performed. Results: There was no difference in whole brain, cerebral or cerebral cortical volumes. Both groups showed marginally smaller cerebral volum... BMC Neurology journals http://www.medworm.com/rss/comments.php?id=692539 Sun, 24 Jun 2007 02:22:13 +0100 692539