MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Neuroscience - Latest articles' source. Fri, 19 Mar 2010 17:57:57 +0100 http://www.medworm.com/index.php?rid=3370234&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F38 Conclusions: Applying tDCS with an extracephalic reference electrode in healthy volunteers did not significantly modulate the activity of the brainstem autonomic centres. Therefore, using an extracephalic reference electrode for tDCS appears safe in healthy volunteers, at least under similar experimental conditions. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3370234 Tue, 16 Mar 2010 00:00:00 +0100 3370234 http://www.medworm.com/index.php?rid=3354160&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F35 Conclusions: These findings demonstrate that EP2 and EP4 agonists stimulate VEGF production in the inner ear, particularly in the spiral ganglions. Moreover, the Flt-1 and Flk-1 expression observed in the present study suggests that VEGF has autocrine and paracrine actions in the cochlea. Thus, EP2 and EP4 might be involved in the mechanisms underlying the therapeutic effects of PGE1 on acute sensorineural hearing loss via VEGF production. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3354160 Thu, 11 Mar 2010 00:00:00 +0100 3354160 http://www.medworm.com/index.php?rid=3354159&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F36 Conclusions: Our data demonstrate that in a gender categorisation task the processing of faces dominate over the processing of voices. Brain activity showed different modulation by top-down and bottom-up information. Top-down influences modulated early brain activity whereas bottom-up interactions occurred relatively late. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3354159 Thu, 11 Mar 2010 00:00:00 +0100 3354159 http://www.medworm.com/index.php?rid=3350116&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F34 Conclusions: Our data show that targeted CNS cell therapy requires blood-brain barrier disruption. MRI-detectable cytotoxic anti-neoplastic cells can be forced to transverse the BBB and accumulate in the perivascular space. The virtual absence of toxicity, the high anti-tumor activity of TALL-104, and the clinical feasibility of human osmotic BBBD suggest that this approach may be adopted to treat brain or spinal cord tumors. In addition, BBBD may favor CNS entry of other cells that normally lack CNS tropism. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3350116 Tue, 09 Mar 2010 00:00:00 +0100 3350116 http://www.medworm.com/index.php?rid=3346332&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F33 Conclusions: It is known that chronic morphine treatment decreases dendritic arborization and hippocampal neurogenesis, and Wnt proteins are essential for these processes. We therefore propose that the morphine-mediated MOR/GPR177 interaction may result in decreased Wnt secretion in the CNS, resulting in atrophy of dendritic arbors and decreased neurogenesis. Our results demonstrate a previously unrecognized role for GPR177 in regulating cellular response to opioid drugs. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3346332 Tue, 09 Mar 2010 00:00:00 +0100 3346332 http://www.medworm.com/index.php?rid=3331104&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F32 Conclusions: Under basal conditions, LDCVs move faster away from the soma than toward the soma, but fewer LDCVs travel anterograde than retrograde. Stimulation decreases average anterograde velocity and increases granule pausing. Data from antibody uptake, quantification of enzyme secretion and appearance of pHluorin fluorescence demonstrate distributed release of peptides all along the axon, not just at terminals. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3331104 Thu, 04 Mar 2010 00:00:00 +0100 3331104 http://www.medworm.com/index.php?rid=3311421&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F27 Conclusions: Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3311421 Fri, 26 Feb 2010 00:00:00 +0100 3311421 http://www.medworm.com/index.php?rid=3311420&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F29 Background: Many studies of cocaine-responsive gene expression have focused on changes occurring during cocaine exposure, but few studies have examined the persistence of these changes with cocaine abstinence. Persistent changes in gene expression, as well as alterations induced during abstinence may underlie long-lasting drug craving and relapse liability. Results: Whole-genome expression analysis was conducted on a rat cocaine binge-abstinence model that has previously been demonstrated to engender increased drug seeking and taking with abstinence. Gene expression changes in two mesolimbic terminal fields (mPFC and NAc) were identified in a comparison of cocaine-naive rats with rats after 10 days of cocaine self-administration followed by 1, 10, or 100 days of enforced abstinence (n=6-11... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3311420 Fri, 26 Feb 2010 00:00:00 +0100 3311420 http://www.medworm.com/index.php?rid=3302173&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F26 Conclusions: We suggest that loss of Pax6 from ES cells reduces their neurogenic capacity but does not necessarily result in the death of derived neurons. We offer these new lines as additional tools for those interested in the generation of chimeras and the analysis of in vitro ES cell models of Pax6 function during neuronal differentiation, embryonic and postnatal development. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3302173 Wed, 24 Feb 2010 00:00:00 +0100 3302173 http://www.medworm.com/index.php?rid=3298146&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F25 Conclusions: In this model of pure apoptotic cell death the protective effects of G-CSF indicate direct actions of G-CSF on motoneurons in vivo. This shows that G-CSF exerts potent anti-apoptotic activities towards motoneurons in vivo and suggests that the protection offered by G-CSF in ALS mouse models is due to its direct neuroprotective activity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3298146 Tue, 23 Feb 2010 00:00:00 +0100 3298146 http://www.medworm.com/index.php?rid=3294459&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F24 Conclusions: We propose that the increased activity of AEFs reflects cortical processing of acoustic properties common to both speech and non-speech stimuli. More specifically, the enhancement is most likely caused by spectral changes brought about by the decrease of amplitude resolution, in particular the introduction of periodic, signal-dependent distortion to the original sound. Converging evidence suggests that the observed AEF amplification could reflect cortical sensitivity to periodic sounds. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3294459 Mon, 22 Feb 2010 00:00:00 +0100 3294459 http://www.medworm.com/index.php?rid=3290731&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F23 Conclusion: The identification of disulphide-linked apoE dimers in human cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3290731 Sat, 20 Feb 2010 00:00:00 +0100 3290731 http://www.medworm.com/index.php?rid=3287500&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F22 Conclusion: This study demonstrates that behaviors can differ significantly between species that appear morphologically very similar, and therefore it is important to consider factors, such as ecology of a species in the wild, when formulating hypotheses about the adaptive significance of a behavior. Our results suggest that evolutionary changes in locomotory behaviors are less likely to be caused by changes in neurotransmitter expression of neurons. Such changes could caused either by subtle changes in neural circuitry or in the function of the signal transduction pathways mediating these behaviors. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3287500 Fri, 19 Feb 2010 00:00:00 +0100 3287500 http://www.medworm.com/index.php?rid=3287501&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F21 Conclusions: Collectively, this study shows that autophagy machinery is robustly induced in cultured neurons subjected to prolonged exposure to excitotoxin, while autophagosome clearance by lysosomal pathway might be impaired. Our data further show that prolonged autophagy contributes to cell death in NMDA-mediated excitotoxicity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3287501 Thu, 18 Feb 2010 00:00:00 +0100 3287501 http://www.medworm.com/index.php?rid=3283389&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F20 Conclusions: RNAi is a powerful tool to knock down Semaphorin receptor expression in neuronal cells in vitro and in vivo. However, when shRNAs are expressed at high levels in CNS neurons, they trigger an adverse tissue response leading to neuronal degradation. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3283389 Thu, 18 Feb 2010 00:00:00 +0100 3283389 http://www.medworm.com/index.php?rid=3283390&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F19 Conclusion: We have identified various neurological abnormalities in this mouse model of Rett syndrome/X-linked mental retardation which may help to elucidate the manner in which MECP2 mutations cause neuronal changes resulting in mental retardation without the confounding effects of seizures, chronic hypoventilation, or other Rett syndrome associated symptoms. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3283390 Wed, 17 Feb 2010 00:00:00 +0100 3283390 http://www.medworm.com/index.php?rid=3258692&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F17 Conclusions: These data demonstrate that an immune response increases sleep in flies in a manner that is gated by the circadian clock and that requires the NFkappaB Relish. These findings support a role of sleep in a recovery process and demonstrate a conserved feature of the Drosophila model of sleep. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3258692 Tue, 09 Feb 2010 00:00:00 +0100 3258692 http://www.medworm.com/index.php?rid=3251019&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F15 Conclusions: These findings indicate that adaptive food seeking /intake can be transformed into maladaptive behaviors and point to "top-down" influence on eating disturbances and to new targets for therapy of aberrant eating behaviors. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3251019 Mon, 08 Feb 2010 00:00:00 +0100 3251019 http://www.medworm.com/index.php?rid=3251018&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F16 Conclusion: These results, although explorative, indicate that during fetal life the Val66Met genotype might influences BDNF protein levels in AF supporting the involvement of this polymorphism in behavioral and functional brain individual differences in the adulthood. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3251018 Mon, 08 Feb 2010 00:00:00 +0100 3251018 http://www.medworm.com/index.php?rid=3243486&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F13 Conclusions: These results strengthen the evidence that perineuronal microglial accumulation (but not T-cell accumulation) is involved in axonal regeneration by intrinsic CNS and other neurons. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3243486 Fri, 05 Feb 2010 00:00:00 +0100 3243486 http://www.medworm.com/index.php?rid=3243485&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F14 Conclusion: This is the first report of long ncRNA expression in neuronal and glial cell differentiation and of the modulation of ncRNA expression by modification of chromatin architecture. These observations explicitly link ncRNA dynamics to neural stem cell fate decisions, specification and epigenetic reprogramming and may have important implications for understanding and treating neuropsychiatric diseases. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3243485 Fri, 05 Feb 2010 00:00:00 +0100 3243485 http://www.medworm.com/index.php?rid=3235580&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F12 Background: The link between early blood- brain barrier (BBB) breakdown and endothelial cell activation in acute stroke remain poorly defined. We hypothesized that P-selectin, a mediator of the early phase of leukocyte recruitment in acute ischemia is also a major contributor to early BBB dysfunction following stroke. This was investigated by examining the relationship between BBB alterations following transient ischemic stroke and expression of cellular adhesion molecule P-selectin using a combination of magnetic resonance molecular imaging (MRMI), intravital microscopy and immunohistochemistry. MRMI was performed using the contrast, gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) conjugated to Sialyl Lewis X (Slex) where the latter is known to bind to activated endothelium via E-... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3235580 Tue, 02 Feb 2010 00:00:00 +0100 3235580 http://www.medworm.com/index.php?rid=3231243&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F11 Conclusions: These results suggest that the revealed clusters contain multisensory neuronal populations that encode content relatedness by selectively responding to congruent audiovisual inputs, since unisensory neuronal populations are assumed to be insensitive to the audiovisual relation. These findings extend our previously revealed mechanism for the integration of letters and speech sounds and demonstrate that fMR-A is sensitive to multisensory congruency effects that may not be revealed in BOLD amplitude per se. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3231243 Tue, 02 Feb 2010 00:00:00 +0100 3231243 http://www.medworm.com/index.php?rid=3216397&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F9 Conclusions: The present study provides mRNA expression data that suggest that levetiracetam attenuates expression of genes known to regulate synaptic remodelling. In the kindled rat, levetiracetam does so by shortening the AD duration thereby reducing the seizure-induced changes in mRNA expression in the hippocampus. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3216397 Wed, 27 Jan 2010 00:00:00 +0100 3216397 http://www.medworm.com/index.php?rid=3216396&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F10 Conclusion: Antidepressants probably induce the activity of CDP-diacylglycerol synthase leading to increased production of CDP-diacylglycerol and facilitation of downstream phosphatidylinositol synthesis. Phosphatidylinositol-dependent signaling cascades exert diverse salutary effects in neural cells, including facilitation of BDNF signaling and neurogenesis. Hence, the present findings should strengthen the notion that modulation of brain phosphatidylinositide signaling probably contributes to the molecular mechanism of diverse antidepressant medications. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3216396 Wed, 27 Jan 2010 00:00:00 +0100 3216396 http://www.medworm.com/index.php?rid=3188999&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F8 Conclusion: Specific targeting of selected subpopulations of CNS neurons for drug delivery by axonal transport holds great promise. The data shown here provide a basic framework for the intraneural pharmacology of this tripartite complex. The pharmacologically efficacious drug delivery demonstrated here verify the fundamental feasibility of using axonal transport for targeted drug delivery. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3188999 Wed, 20 Jan 2010 00:00:00 +0100 3188999 http://www.medworm.com/index.php?rid=3189000&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F7 Conclusions: Our results show that these mouse NS cells may be suitable for a series of applications in high-throughput format. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3189000 Tue, 19 Jan 2010 00:00:00 +0100 3189000 http://www.medworm.com/index.php?rid=3185120&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F6 Conclusions: In Ciona intestinalis, glycine receptors, glycinergic transmission and putative glycinergic interneurons, have a key role in coordinating swimming movements through a simple CPG that is present in the motor ganglion and nerve cord. Thus, the strong association between glycine receptors and vertebrate locomotory networks may now be extended to include the phylum chordata. The results suggest that the basic network for 'spinal-like' locomotion is likely to have existed in the common ancestor of extant chordates some 650 M years ago. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3185120 Tue, 19 Jan 2010 00:00:00 +0100 3185120 http://www.medworm.com/index.php?rid=3175677&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F5 Conclusions: Pseudoreplication can undermine the conclusions of a statistical analysis, and it would be easier to detect if the sample size, degrees of freedom, the test statistic, and precise p-values are reported. This information should be a requirement for all publications. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3175677 Thu, 14 Jan 2010 00:00:00 +0100 3175677 http://www.medworm.com/index.php?rid=3148919&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F3 Conclusions: We conclude that local cortical networks are very likely to use a highly skewed weight distribution, as predicted by theory, to optimize information retention. Fixed distributions impose constraints on learning, however. The network must have mechanisms for preserving the overall weight distribution while allowing individual connection strengths to vary. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3148919 Wed, 06 Jan 2010 00:00:00 +0100 3148919 http://www.medworm.com/index.php?rid=3142365&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F1 Conclusions: :A pattern of morphological changes in lactacystin-lesioned animals has been identified, as well as alterations in nigral T2 relaxivity. The significant relationship of morphological changes with behavioural and histological outcomes in this model raises the possibility that these may be useful non-invasive surrogate markers of nigrostriatal degeneration in vivo. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3142365 Tue, 05 Jan 2010 00:00:00 +0100 3142365 http://www.medworm.com/index.php?rid=3142364&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F2 Conclusions: The findings highlight the critical role that survivin plays during neural development, deficiencies of which dramatically impact on postnatal neural function. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3142364 Tue, 05 Jan 2010 00:00:00 +0100 3142364 http://www.medworm.com/index.php?rid=3114945&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F155 Conclusion: In spite of substantial cortical malformations in the frontal and parietal lobes, the PMG monkey exhibits surprisingly normal structure and function of the corticospinal system. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3114945 Wed, 23 Dec 2009 00:00:00 +0100 3114945 http://www.medworm.com/index.php?rid=3114946&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F154 Conclusions: We conclude that differential dopaminergic signaling as revealed in animal studies is not only represented locally by involvement of distinct brain regions but also by distinct BOLD signal characteristics. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3114946 Tue, 22 Dec 2009 00:00:00 +0100 3114946 http://www.medworm.com/index.php?rid=3111057&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F153 Conclusions: The spatiotemporally restricted expression patterns of 7 classic cadherins and 8 delta-protocadherins indicate that cadherins provide a combinatorial adhesive code that specifies developing retinal cell populations and intraretinal as well as retinofugal neural circuits in the developing ferret retina. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3111057 Tue, 22 Dec 2009 00:00:00 +0100 3111057 http://www.medworm.com/index.php?rid=3108256&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F151 Conclusions: The hemodynamic response function subtending BOLD signal may present a delay in peak latency that arises as patients advance from the acute to the subacute stroke phase. This delay is related to the deterioration of cerebral hemodynamics. These findings suggest that remodeling the fMRI hemodynamic response function in the different phases of stroke may optimize the detection of BOLD signal changes. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3108256 Sun, 20 Dec 2009 00:00:00 +0100 3108256 http://www.medworm.com/index.php?rid=3104894&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F149 Background: Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal extracellular signal-regulated kinase (ERK1/2) and cAMP response element-binding protein (CREB) are implicated in the impaired learning and memory in lactational and adolescent rat hippocampus following developmental ID and hypothyroidism. Methods: Three developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5ppm or 15ppm)-added drinking water from gestational day (GD) 6 till postnatal day (PN) 28. Then, the total and phorsporylated ERK1/2 and total and phorsporylated CREB in the hippocampus were detected with western blot on PN14, PN21, PN28 and P... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3104894 Fri, 18 Dec 2009 00:00:00 +0100 3104894 http://www.medworm.com/index.php?rid=3096585&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F148 Conclusions: We conclude that expression of WldS protein has no adverse effects on non-neuronal tissue at a basal level in vivo, supporting the possibility of its safe use in future therapeutic strategies targeting axonal and/or synaptic compartments in patients with neurodegenerative disease. Future experiments determining whether WldS protein can modify responses to injury in non-neuronal tissue are now required. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3096585 Wed, 16 Dec 2009 00:00:00 +0100 3096585 http://www.medworm.com/index.php?rid=3089091&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F147 Conclusions: Our results suggest that the direction and amplitude of orientation preference shifts in V1 depend on location within the orientation map. This anisotropy of adaptation-induced plasticity, comparable to that of the visual cortex itself, could have important implications for our understanding of visual adaptation at the psychophysical level. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3089091 Mon, 14 Dec 2009 00:00:00 +0100 3089091 http://www.medworm.com/index.php?rid=3075348&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F145 Conclusions: Faster amygdala response to novelty may reflect a computational bias that leads to greater neophobic responses and represents a mechanism for the development of social anxiety. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3075348 Thu, 10 Dec 2009 00:00:00 +0100 3075348 http://www.medworm.com/index.php?rid=3044443&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F143 Conclusions: We found that discrimination training differentially modulates the cortical responses to pitch changes and to envelope fluctuation changes of AM tones. This suggests that discrimination between AM tones requires additional neuronal mechanisms compared to discrimination process between pure tones. After the training, the subjects demonstrated an involuntary attention switch to the deviant stimulus (represented by the P3a-component in the MEG) even though attention was not prerequisite. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3044443 Tue, 01 Dec 2009 00:00:00 +0100 3044443 http://www.medworm.com/index.php?rid=3039579&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F140 Conclusion: Together, these results show that area V4 participates, at the population level, in the coding of complex shape from the shading patterns coming from the illumination of the surface of corrugated objects. Hence V4 provides important information for one of the steps of cortical processing of the 3D aspect of objects in natural light environment. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3039579 Mon, 30 Nov 2009 00:00:00 +0100 3039579 http://www.medworm.com/index.php?rid=3039578&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F142 Conclusions: Delivery of the read-through inducing compound TC007 reduces the disease-associated phenotype in SMA mice, however, does not significantly extend survival. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3039578 Mon, 30 Nov 2009 00:00:00 +0100 3039578 http://www.medworm.com/index.php?rid=3035845&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F139 CONCLUSION: Src kinase increase numbers of newborn neuronal cells in the DG via the activation of Raf/ERK/CREB signaling cascade after cerebral ischemia. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3035845 Fri, 27 Nov 2009 00:00:00 +0100 3035845 http://www.medworm.com/index.php?rid=3033501&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F138 Conclusions: This supports the idea that chronic pain can alter thalamocortical connections causing a disruption of thalamic feedback, and the view of chronic pain as a thalamocortical dysrhythmia. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3033501 Thu, 26 Nov 2009 00:00:00 +0100 3033501 http://www.medworm.com/index.php?rid=3015206&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F136 Conclusions: Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3015206 Fri, 20 Nov 2009 00:00:00 +0100 3015206 http://www.medworm.com/index.php?rid=3007812&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F135 Conclusions: These observations contribute to a better understanding of the brain response to peripheral inflammation and pave the way to study their impact on the progression of several disorders of the central nervous system in which inflammation is known to be implicated. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=3007812 Wed, 18 Nov 2009 00:00:00 +0100 3007812 http://www.medworm.com/index.php?rid=2999386&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F134 Conclusion: We found that PEA-15 null mice have spatial learning disabilities that are similar to those of mice where ERK or RSK2 function is impaired. We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2999386 Mon, 16 Nov 2009 00:00:00 +0100 2999386 http://www.medworm.com/index.php?rid=2992570&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F133 Conclusions: We argue that the observed slow oscillation corresponds to the late periodic epileptiform discharge phase of status epilepticus, and that the PRF may be involved in the progression of status epilepticus. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2992570 Fri, 13 Nov 2009 00:00:00 +0100 2992570 http://www.medworm.com/index.php?rid=2988889&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F132 Conclusion: PKCI/HINT1 KO mice displayed a phenotype of behavioral and endocrine features which indicate changes of mood function, including anxiolytic-like and anti-depressant like behaviors, in conjunction with an elevated corticosterone level in plasma. These results suggest that the PKCI/HINT 1 gene could be important for the mood regulation function in the CNS. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2988889 Fri, 13 Nov 2009 00:00:00 +0100 2988889 http://www.medworm.com/index.php?rid=2939098&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F131 Conclusions: Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2939098 Thu, 29 Oct 2009 00:00:00 +0100 2939098 http://www.medworm.com/index.php?rid=2934534&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F130 Conclusions: Neurons are among the most long-lived cells in the body and are subject to low levels of toxic challenges throughout life. We have demonstrated that progranulin is abundantly expressed in motor neurons and is cytoprotective over prolonged periods when over-expressed in a neuronal cell line. This work highlights the importance of progranulin as neuroprotective growth factor and may represent a therapeutic target for neurodegenerative diseases including motor neuron disease. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2934534 Tue, 27 Oct 2009 00:00:00 +0100 2934534 http://www.medworm.com/index.php?rid=2930820&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F129 Conclusions: We conclude that FTO mRNA is present mainly in sites related to hunger/satiation control; changes in hypothalamic FTO expression are associated with cues related to energy intake rather than feeding reward. In line with that, neurons involved in feeding termination express FTO. Interestingly, baseline FTO expression appears linked not only with energy intake but also energy metabolism. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2930820 Tue, 27 Oct 2009 00:00:00 +0100 2930820 http://www.medworm.com/index.php?rid=2915926&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F128 Conclusions: The present study investigating the influence and mechanisms of CSPGs on the differentiation and migration of NPCs should help us to understand the basic biology of NPCs during CNS development and provide new insights into developing new strategies for the treatment of the neurological disorders in the CNS. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2915926 Tue, 20 Oct 2009 23:00:00 +0100 2915926 http://www.medworm.com/index.php?rid=2865477&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F126 Conclusion: The present study advises our community to proceed with caution to use the minimally invasive intravenous delivery of low dose minocycline in order to afford neuroprotection that is safe for stroke. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2865477 Mon, 05 Oct 2009 23:00:00 +0100 2865477 http://www.medworm.com/index.php?rid=2842376&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F124 Conclusions: These results indicate that increased mEPSC frequency persists well beyond the 2 hour transcription-independent phase of plasticity in this model. This long-lasting mEPSC upregulation is transcription-dependent and requires ongoing action potential activity during the initial 2 hour period but not thereafter. Thus mEPSC upregulation may underlie the long term, transcription-dependent persistence of action potential bursting. This provides mechanistic insight to link gene candidates already identified by gene chip analysis to long lasting plasticity in this in vitro model. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2842376 Mon, 28 Sep 2009 23:00:00 +0100 2842376 http://www.medworm.com/index.php?rid=2838766&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F123 Conclusions: This alteration in the balance between pro- and anti-apoptotic factors by chronic NMDA receptor activation in this animal model may contribute to neuronal loss, and further suggests that the model can be used to examine multiple processes involved in excitotoxicity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2838766 Sun, 27 Sep 2009 23:00:00 +0100 2838766 http://www.medworm.com/index.php?rid=2831954&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F122 Conclusion: Neural progenitors were produced from murine ES cells by a novel method that induced neuroectoderm cells by a combination of nonadherent conditions and serum starvation, in contrast to the embryoid body method in which neuroectoderm cells must be selected after formation of all three germ layers. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2831954 Wed, 23 Sep 2009 23:00:00 +0100 2831954 http://www.medworm.com/index.php?rid=2828016&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F121 Conclusions: We conclude that the new cDNA library is a faithful representation of human ON and EST data provide an initial overview of gene expression patterns in this tissue. The data provide clues for tissue-specific and species-specific properties of human ON that will help in design of therapeutic models. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2828016 Wed, 23 Sep 2009 23:00:00 +0100 2828016 http://www.medworm.com/index.php?rid=2862227&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2Fbmcneurosci%2F In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow. Results: To test our hypothesis, we stimulated the vestibular organs of 25 healthy subjects by pitch tilt (stimulates both canals and otoliths) and by translation on a centrifuge (stimulates otoliths and not the canals) at five frequencies: 0.5, 0.25, 0.125 and 0.0625 Hz for 80 sec and 0.03125 Hz for 160 sec. Changes in cerebral flow velocity (by transcranial Doppler) and blood pressure (by Finapres) were similar during both stimuli and dependent on frequency of stimulation (P (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2862227 Tue, 22 Sep 2009 23:00:00 +0100 2862227 http://www.medworm.com/index.php?rid=2823827&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F119 In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow. Results: To test our hypothesis, we stimulated the vestibular organs of 25 healthy subjects by pitch tilt (stimulates both canals and otoliths) and by translation on a centrifuge (stimulates otoliths and not the canals) at five frequencies: 0.5, 0.25, 0.125 and 0.0625 Hz for 80 sec and 0.03125 Hz for 160 sec. Changes in cerebral flow velocity (by transcranial Doppler) and blood pressure (by Finapres) were similar during both stimuli and dependent on frequency of stimulation (P (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2823827 Tue, 22 Sep 2009 23:00:00 +0100 2823827 http://www.medworm.com/index.php?rid=2823826&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F120 Conclusion: We have found that a secretory phospholipase (nPLA) purified from snake venom could reduce infarct volume in rodent stroke model. nPLA, has also been found to reduce neuronal cell death, apoptosis and promote cell survival in in-vitro ischemic conditions. In all conditions, the protective effects could be seen at sub-lethal concentrations of the protein. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2823826 Tue, 22 Sep 2009 23:00:00 +0100 2823826 http://www.medworm.com/index.php?rid=2823828&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F118 Conclusions: The results show for the first time that treatment-induced language recovery in the chronic stage after stroke is a dynamic process. Initially, brain regions involved in memory encoding, attention, and multimodal integration mediated treatment success. In contrast, long-term treatment success was predicted mainly by activity increases in the so-called 'classical' language regions. The results suggest that besides perilesional and homologue language-associated regions, functional integrity of domain-unspecific memory structures may be a prerequisite for successful (intensive) language interventions. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2823828 Mon, 21 Sep 2009 23:00:00 +0100 2823828 http://www.medworm.com/index.php?rid=2819814&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F117 Conclusions: Transplantation of NSCs genetically modified to differentiate into an oligodendrocytic lineage may be an effective strategy to improve functional outcomes following spinal cord trauma. The present study suggests that molecular factors governing cell fate decisions can be manipulated to enhance reparative potential of the cell-based therapy. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2819814 Mon, 21 Sep 2009 23:00:00 +0100 2819814 http://www.medworm.com/index.php?rid=2796295&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F115 Conclusions: The results show that the spatiotemporal patterns of spiking activity among cells in the small neuronal ensemble contain much information that is specifically useful for the stimulus comparison. Small neuronal networks in the hippocampal CA1 might therefore act as a comparator during recognition memory tasks. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2796295 Mon, 14 Sep 2009 23:00:00 +0100 2796295 http://www.medworm.com/index.php?rid=2796294&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F116 Conclusions: The data indicate bilateral involvement of both hemispheres in idiom comprehension, including the right MTG after 350 ms and the right medial frontal gyrus in the time windows 270-300 and 500-780 ms. In addition, the activation of left and right limbic regions (400-450 ms) suggests that they have a role in the emotional connotation of colourful idiomatic language. The data support the view that there is direct access to the idiomatic meaning of figurative language, not dependent on the suppression of its literal meaning, for which the LIFG was previously thought to be responsible. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2796294 Mon, 14 Sep 2009 23:00:00 +0100 2796294 http://www.medworm.com/index.php?rid=2778224&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F114 Conclusion: Using a component-free ERP analysis that provides a precise timing of the visual system sensitivity to image structure, the current study demonstrates that older observers accumulate face information more slowly than younger subjects. Additionally, the N170 appears to be less face-sensitive in older observers. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2778224 Tue, 08 Sep 2009 23:00:00 +0100 2778224 http://www.medworm.com/index.php?rid=2774500&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F113 Conclusions: These results suggest that BNIP3 and EndoG play important roles in hippocampal neuronal apoptosis following ischemia, and mitochondrial BNIP3 is a signal protein upstream of EndoG that can induce neuronal death. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2774500 Mon, 07 Sep 2009 23:00:00 +0100 2774500 http://www.medworm.com/index.php?rid=2772331&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F112 Conclusion: These results show an upregulation of PMCA activity and PMCA isoforms expression during brain development in mouse, with specific localizations mainly in cerebellum. Overall, our findings support a close relationship between the ontogeny of PMCA isoforms and specific requirements of Ca2+ during development of different brain areas. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2772331 Sun, 06 Sep 2009 23:00:00 +0100 2772331 http://www.medworm.com/index.php?rid=2761679&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F110 Conclusion: The results of this study show that long-term consumption of caffeine can induce ventriculomegaly, which is mediated in part by increased production of CSF. Moreover, we also showed that adenosine receptor signaling can regulate the production of CSF by controlling the expression of Na+, K+-ATPase and CBF. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2761679 Wed, 02 Sep 2009 23:00:00 +0100 2761679 http://www.medworm.com/index.php?rid=2761678&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F111 Conclusion: This study indicates that HSP72 overexpression appears to be critical to the development of thermotolerance and protection from heat-induced hypothalamic ischemic and oxidative damage. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2761678 Wed, 02 Sep 2009 23:00:00 +0100 2761678 http://www.medworm.com/index.php?rid=2757501&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F109 Conclusions: The present study further validates Drosophila as a valuable model for preclinical testing of drugs with therapeutic potential for neurodegenerative diseases. The lower cost and amenability to high throughput testing make Drosophila PD models effective in vivo tools for screening novel therapeutic compounds. If our findings can be further validated in mammalian PD models, they would implicate drugs combining antioxidant and anti-inflammatory properties as strong therapeutic candidates for mechanism-based PD treatment. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2757501 Mon, 31 Aug 2009 23:00:00 +0100 2757501 http://www.medworm.com/index.php?rid=2751621&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F108 Conclusions: These findings suggest that the deficiency of neither COX-1 nor COX-2 is sufficient to alter cognitive outcomes following TBI in mice. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2751621 Sun, 30 Aug 2009 23:00:00 +0100 2751621 http://www.medworm.com/index.php?rid=2741158&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F107 Conclusion: This report shows that enhancer trapping can be applied to label distinct morphological types of bipolar cells in the zebrafish retina. The genetic labelling of these cells yielded co-expression of a modified Gal4 transcription activator and the fluorescent marker eGFP. Our work also demonstrates the potential utility of the Gal4-UAS system for induction of other transgenes, including a bacterial nitroreductase fusion gene, which can facilitate analysis of bipolar cell differentiation and how the retina recovers from specific ablation of these cells. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2741158 Wed, 26 Aug 2009 23:00:00 +0100 2741158 http://www.medworm.com/index.php?rid=2737518&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F105 Conclusions: These results support previous findings that alertness may be mediated by the circadian system, but it does not seem to be the only light-sensitive pathway that can affect alertness at night. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2737518 Wed, 26 Aug 2009 23:00:00 +0100 2737518 http://www.medworm.com/index.php?rid=2733898&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F104 Conclusions: In summary, the automated detection method avoids the subjectivity of visual analysis and offers a rapid, easily accessible (http://axograph.com/source/abr.html) approach to measure hearing threshold levels in auditory brainstem response. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2733898 Tue, 25 Aug 2009 23:00:00 +0100 2733898 http://www.medworm.com/index.php?rid=2733899&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F103 About 50% of humans with aneurysmal subarachnoid hemorrhage (SAH) die and many survivors have neurological and neurocognitive dysfunction. Animal studies usually focused on cerebral vasospasm and sometimes neuronal injury. The difference in endpoints may contribute to lack of translation of treatments effective in animals to humans. We reviewed prior animal studies of SAH to determine what neurological and neurobehavioral endpoints had been used, whether they differentiated between appropriate controls and animals with SAH, whether treatment effects were reported and whether they correlated with vasospasm. Only a few studies in rats examined learning and memory. It is concluded that more studies are needed to fully characterize neurobehavioral performance in animals with SAH and assess eff... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2733899 Mon, 24 Aug 2009 23:00:00 +0100 2733899 http://www.medworm.com/index.php?rid=2729937&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F102 Conclusions: Overall, results of the present study demonstrate that idiopathic scoliosis patients have an alteration in cognitive integration of vestibular signals. It is possible that severe spine deformity developed partly due to impaired vestibular information travelling from the cerebellum to the vestibular cortical network or alteration in the cortical mechanisms processing the vestibular signals. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2729937 Mon, 24 Aug 2009 23:00:00 +0100 2729937 http://www.medworm.com/index.php?rid=2715772&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F99 Conclusion: In the hippocampus, DGKbeta is expressed in both projection neurons and interneurons and is accumulated at the perisynapse of dendritic spines in asymmetrical synapses. Transfection experiments suggest that DGKbeta may be involved in the molecular machineries of dendrite outgrowth and spinogenesis through its kinase activity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2715772 Tue, 18 Aug 2009 23:00:00 +0100 2715772 http://www.medworm.com/index.php?rid=2715771&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F100 Conclusion: Our N170 findings provide support for both the quantitative and qualitative accounts for face rotation effects. Although the qualitative explanation predicted the curvilinear shape of N170 modulations by face misrotations, topographical and source modeling findings suggest that the same brain regions, and thus the same mechanisms, are probably at work when processing upright and rotated faces. Taken collectively, our results indicate that the same processing mechanisms may be involved across the whole range of face orientations, but would operate in a non-linear fashion. Finally, the response tuning of the N170 to rotated faces extends previous reports and further demonstrates that face inversion affects perceptual analyses of faces, which is reflected within the time range of ... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2715771 Tue, 18 Aug 2009 23:00:00 +0100 2715771 http://www.medworm.com/index.php?rid=2711926&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F98 Conclusions: These data support a regulatory role for miRNAs during the transition from neuronal progenitors into the earliest differentiating cortical neurons. In addition, by supplying a robust data set in which miRNA and mRNA profiles originate from the same purified cell type, this empirical study may facilitate the development of new algorithms to integrate various "-omics" data sets. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2711926 Tue, 18 Aug 2009 23:00:00 +0100 2711926 http://www.medworm.com/index.php?rid=2702148&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F96 Conclusions. Taken together, these data suggest that NT enhances DA release principally by inhibiting the function of terminal D2 autoreceptors and not by more direct mechanisms such as facilitation of terminal calcium influx. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2702148 Thu, 13 Aug 2009 23:00:00 +0100 2702148 http://www.medworm.com/index.php?rid=2678494&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F94 Conclusions: The reduced severity of autoimmune encephalomyelitis in AQP4 deficiency suggests AQP4 as a novel determinant in autoimmune inflammatory diseases of the central nervous system and hence a potential drug target. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2678494 Wed, 05 Aug 2009 23:00:00 +0100 2678494 http://www.medworm.com/index.php?rid=2670678&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F91 Conclusions: Applying high-resolution fMRI while subjects were performing an explicit emotion recognition task revealed bilateral amygdala activation to all emotions and neutral expressions presented. This mechanism seems to operate similarly in healthy females and males and for both in-group and out-group ethnicities. Our results support the assumption that an intact amygdala response is fundamental in the processing of these salient stimuli due the amygdala's relevance detecting function. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2670678 Mon, 03 Aug 2009 23:00:00 +0100 2670678 http://www.medworm.com/index.php?rid=2670677&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F92 Conclusions: In light of the relatively delayed transcriptional activation of the DRD3 and DRD4 genes, we propose that slow-reacting hypoxia sensitive transcription factors might be involved in the transactivation of DRD3 and DRD4 promoters in hypoxia. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2670677 Mon, 03 Aug 2009 23:00:00 +0100 2670677 http://www.medworm.com/index.php?rid=2657419&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F90 Conclusions: Differential responses to optic nerve crush between two widely used strains of mice were used to define molecular networks associated with ganglion cell death and reactive gliosis. These results form the basis for our continuing interest in the modifiers of retinal injury. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2657419 Wed, 29 Jul 2009 23:00:00 +0100 2657419 http://www.medworm.com/index.php?rid=2653548&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F89 Conclusions: The presence of the P600 suggests that native speakers applied a grammatical rule. In contrast, non-native speakers appeared to use a lexical form-based processing strategy. Thus, the processing mechanisms acquired in the language learning task were only partly comparable to those applied by competent native speakers. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2653548 Tue, 28 Jul 2009 23:00:00 +0100 2653548 http://www.medworm.com/index.php?rid=2644977&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F88 Conclusions: Our data confirmed that paraquat-induced neurotoxicity represents a convenient rat model of Parkinsonian neurodegeneration suitable for mechanistic and neuroprotective studies. This is the first preclinical evaluation of a water-soluble coenzyme Q10 formulation showing the evidence of prophylactic neuroprotection at clinically relevant doses. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2644977 Sun, 26 Jul 2009 23:00:00 +0100 2644977 http://www.medworm.com/index.php?rid=2634210&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2Fbmcneurosci%2F Conclusions: In conclusion the results confirm that CTX0E03 cells downregulated c-mycERTAM transgene expression both in vitro following EGF, bFGF and 4-OHT withdrawal and in vivo following implantation in MCAo rat brain. The silencing of the c-mycERTAM transgene in vivo provides an additional safety feature of CTX0E03 cells for potential clinical application. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2634210 Mon, 20 Jul 2009 23:00:00 +0100 2634210 http://www.medworm.com/index.php?rid=2625811&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F86 Conclusions: In conclusion the results confirm that CTX0E03 cells downregulated c-mycERTAM transgene expression both in vitro following EGF, bFGF and 4-OHT withdrawal and in vivo following implantation in MCAo rat brain. The silencing of the c-mycERTAM transgene in vivo provides an additional safety feature of CTX0E03 cells for potential clinical application. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2625811 Mon, 20 Jul 2009 23:00:00 +0100 2625811 http://www.medworm.com/index.php?rid=2621417&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F85 Conclusions: These findings suggest that differential neural circuit abnormalities may be present in the left and right auditory cortices in schizophrenia. In addition, they provide further support for the hypothesis that hallucinations are related to cortical hyperexcitability, which is manifested by an increased propensity for high-frequency synchronization in modality-specific cortical areas. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2621417 Sun, 19 Jul 2009 23:00:00 +0100 2621417 http://www.medworm.com/index.php?rid=2613693&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F83 Conclusions: It can be shown that stimulation with affective pictures lead to an enhanced activity in occipital region as compared to neutral pictures. However, the focus of differentiation is not stable over time but shifts into temporal and parietal regions within four seconds of stimulation. Thus, it can be crucial to carefully choose regions of interests and time intervals when analyzing the affective modulation of cortical activity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2613693 Thu, 16 Jul 2009 23:00:00 +0100 2613693 http://www.medworm.com/index.php?rid=2610741&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F81 Conclusions: The new toolbox presented here implements fast and data-robust computations of the most relevant quantities used in information theoretic analysis of neural data. The toolbox can be easily used within Matlab, the environment used by most neuroscience laboratories for the acquisition, preprocessing and plotting of neural data. It can therefore significantly enlarge the domain of application of information theory to neuroscience, and lead to new discoveries about the neural code. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2610741 Wed, 15 Jul 2009 23:00:00 +0100 2610741 http://www.medworm.com/index.php?rid=2610740&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F82 Conclusions: This study highlights the need for a thorough experimental design to test novel neuroprotective compounds in experimental stroke investigations incorporating: a positive reference compound, different models of focal ischaemia, varying the duration of ischaemia, and objective in vivo assessments within a single study. This procedure will help us to minimise the translation of less efficacious compounds. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2610740 Wed, 15 Jul 2009 23:00:00 +0100 2610740 http://www.medworm.com/index.php?rid=2605813&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F80 Conclusion: Single-molecular tracking using QDs has provided direct evidence that the clustering of AChRs in muscle cells in response to synaptogenic stimuli is achieved by two distinct cellular processes: the Brownian motion of receptors in the membrane and their trapping and immobilization at the synaptic specialization. This study also provides a clearer picture of the "trap" that it is not a uniformly sticky area but consists of discrete foci at which AChRs are immobilized. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2605813 Wed, 15 Jul 2009 23:00:00 +0100 2605813 http://www.medworm.com/index.php?rid=2605815&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F78 Conclusions: : These data demonstrate that, in mice, the expression of nNOS in some hypothalamic regions involved in the control of reproduction and characterized by a large number of estrogen receptors is under the control of gonadal hormones and may vary according to the rapid variations of hormonal levels that take place during the estrous cycle. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2605815 Tue, 14 Jul 2009 23:00:00 +0100 2605815 http://www.medworm.com/index.php?rid=2605814&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F79 Conclusion: NBO can be safely co-administered with tPA. The efficacy of tPA thrombolysis is not affected and there is no induction of brain hemorrhage or edema. These experimental results require clinical confirmation. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2605814 Tue, 14 Jul 2009 23:00:00 +0100 2605814 http://www.medworm.com/index.php?rid=2601872&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F77 Conclusion: The protective effect of recombinant erythropoietin is not mediated by reducing the burden of DNA platination in the target cells, but it is likely to be due to a higher resistance of the target cells to the adverse effect of DNA damage. The increased frequency of intact mitochondria might also contribute to this protective role. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2601872 Tue, 14 Jul 2009 23:00:00 +0100 2601872 http://www.medworm.com/index.php?rid=2601875&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F74 CONCLUSION: Src induces up-regulation of ERK activity and its target transcription factors, CREB and ER alpha, through attenuation of PP2A activity. Therefore, activation of ERK is the result of a crosstalk between two pathways, Raf-dependent positive regulators and PP2A-dependent negative regulators. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2601875 Mon, 13 Jul 2009 23:00:00 +0100 2601875 http://www.medworm.com/index.php?rid=2601874&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F75 Conclusion: These results are consistent with a role of medial prefrontal cortex in controlled action and inferior frontal cortex in orienting attention. We discussed these findings with respect to the process of attentional monitoring and inhibitory motor control during stop signal inhibition. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2601874 Mon, 13 Jul 2009 23:00:00 +0100 2601874 http://www.medworm.com/index.php?rid=2601873&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F76 Conclusions: The method introduced here is simple and easy to perform and might be applicable in the clinical setting. The results are in keeping with previous findings showing bihemispheric involvement in the complex task of sensory pharyngeal processing. They might also explain changes in deglutition after hemispheric strokes. The ipsilaterally lateralized processing is surprising and needs further investigation. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2601873 Mon, 13 Jul 2009 23:00:00 +0100 2601873 http://www.medworm.com/index.php?rid=2583998&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F73 Conclusions: We have found that TP compounds not only blocked mhtt-induced aggregation, but also alleviated early cellular dysfunctions that preclude aggregate formation. Our data suggest TP molecules may be used as lead compounds for prevention or treatment of multiple neurodegenerative diseases including HD and AD. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2583998 Tue, 07 Jul 2009 23:00:00 +0100 2583998 http://www.medworm.com/index.php?rid=2576353&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F72 Conclusions: Our data support the hypothesis that PMd is important for continuous motor learning, specifically via off-line consolidation of learned motor behaviors. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2576353 Mon, 06 Jul 2009 23:00:00 +0100 2576353 http://www.medworm.com/index.php?rid=2560888&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F71 Conclusions: In the present study functional cortical changes elicited by oral sensory stimulation could be demonstrated. We suggest that these results reflect short-term cortical plasticity of sensory swallowing areas. These findings facilitate our understanding of the role of cortical reorganization in dysphagia treatment and recovery. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2560888 Mon, 29 Jun 2009 23:00:00 +0100 2560888 http://www.medworm.com/index.php?rid=2552820&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F70 Conclusions: The present results are consistent with calyx and dimorphic, but not bouton, afferent vestibular neurons expressing H3 receptors. This study provides a molecular substrate for the effects of histamine-related antivertigo drugs acting on (or binding to) H3 receptors, and suggest a potential target for the treatment of vestibular disorders of peripheral origin. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2552820 Sun, 28 Jun 2009 23:00:00 +0100 2552820 http://www.medworm.com/index.php?rid=2527594&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F69 Conclusions: Our results suggest that frontal LPP is elicited by contextual blending of evaluative judgments of in-/outgroup information and positive vs. negative valence association and confirm recent research relating in-/outgroup ERP modulation and frontal LPP. LPP modulation may cohere with implicit measures of attitudes. The convergence of measures that were observed supports the idea that racial and valence evaluations are strongly influenced by context. This result adds to a growing set of evidence concerning contextual sensitivity of different measures of prejudice. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2527594 Thu, 25 Jun 2009 23:00:00 +0100 2527594 http://www.medworm.com/index.php?rid=2515082&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F67 Conclusion: These results provide evidence for the existence of various subtypes of dyslexia characterized by different brain phenotypes. In addition, behavioural analyses suggest that these brain phenotypes relate to different deficits of automatization of language-based processes such as grapheme/phoneme correspondence or rapid access to lexicon entries. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2515082 Wed, 24 Jun 2009 23:00:00 +0100 2515082 http://www.medworm.com/index.php?rid=2515081&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F68 Conclusions: Genomic region covering 67 kb of human BDNF gene, 84 kb of upstream and 17 kb of downstream sequences is sufficient to drive tissue-specific and kainic acid-induced expression of the reporter gene in transgenic mice. The pattern of expression of the transgene is highly similar with BDNF gene expression in mouse and human. This is the first study to show that human BDNF gene is regulated by neural activity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2515081 Wed, 24 Jun 2009 23:00:00 +0100 2515081 http://www.medworm.com/index.php?rid=2508385&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F65 Conclusions: Our findings support the hypothesis that SCG NET is segregated prior totransport from the cell body from proteins comprising large dense core vesicles. Oncelocalized to presynaptic boutons, NET does not recycle via VMAT2-positive, smalldense core vesicles. Finally, once NET reaches presynaptic plasma membranes, thetransporter localizes to syntaxin 1A-rich plasma membrane domains, with a portionfound in cholera toxin-demarcated lipid rafts. Our findings indicate that activity-dependentinsertion of NET into the SCG plasma membrane derives from vesiclesdistinct from those that deliver NE. Moreover, NET is localized in presynapticmembranes in a manner that can take advantage of regulatory processes targeting lipidraft subdomains. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508385 Mon, 22 Jun 2009 23:00:00 +0100 2508385 http://www.medworm.com/index.php?rid=2508384&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F66 Conclusions: Our data demonstrate that activity of serotonergic and corazonergic neurons contribute to the control of larval locomotion by light. We conclude that this control is carried out by 5-HT neurons located in the brain hemispheres, but does not appear to occur at the photoreceptor level and may be mediated by 5-HT1ADro receptors. These findings provide new insights into the function of 5-HT neurons in Drosophila larval behavior as well as into the mechanisms underlying regulation of larval response to light. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508384 Mon, 22 Jun 2009 23:00:00 +0100 2508384 http://www.medworm.com/index.php?rid=2508388&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F62 Conclusion: These results suggest that bilobalide may modulate specific 5-HT receptor subtypes, which involves interplay with dopamine transmission. Additional studies for the function of bilobalide in neurotransmitter systems could aid in our understanding of its neuroprotective properties. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508388 Sun, 21 Jun 2009 23:00:00 +0100 2508388 http://www.medworm.com/index.php?rid=2508387&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F63 Conclusion: These data best support the hypothesis that different brain regions have variable intrinsic vulnerabilities to neuronal injury caused by the AIDS virus. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508387 Sun, 21 Jun 2009 23:00:00 +0100 2508387 http://www.medworm.com/index.php?rid=2508386&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F64 Conclusion: In this study, by fluorescence measurement of cytosolic calcium and using simultaneous [Ca2+]i and [Ca2+]mito measurements, we are able to separate and simultaneously monitor cytosolic and mitochondrial calcium concentrations in individual cells an established cellular model of ALS. The primary goals of this paper are (1) method development, and (2) screening for deficits in mutant cells on the single cell level. On the technological level, our method promises to serve as a valuable tool to identify mitochondrial and Ca2+-related defects during G93A-mediated MN degeneration. In addition, our experiments support a model where a specialized interplay between cytosolic calcium profiles and mitochondrial mechanisms contribute to the selective degeneration of neurons in ALS. (Source... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508386 Sun, 21 Jun 2009 23:00:00 +0100 2508386 http://www.medworm.com/index.php?rid=2508390&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F60 Conclusions: Medaka fish undergo abnormalities in the PNS when pmp22 transcription increases. This result indicates that an adequate pmp22 transcription level is necessary for correct myelination of jawed vertebrates. Comparison of pmp22 orthologs between distantly related species identifies evolutionary conserved sequences that contribute to precise regulation of pmp22 expression. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508390 Tue, 16 Jun 2009 23:00:00 +0100 2508390 http://www.medworm.com/index.php?rid=2508389&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F61 Conclusion: Kalirin12 may play a role in coordinating Rho GTPase-mediated changes in the actin cytoskeleton with dynamin-mediated changes in membrane trafficking. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508389 Tue, 16 Jun 2009 23:00:00 +0100 2508389 http://www.medworm.com/index.php?rid=2508391&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F59 Conclusions: Such mechanisms explain how gender biases in some DAT-dependent diseases can occur. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508391 Mon, 15 Jun 2009 23:00:00 +0100 2508391 http://www.medworm.com/index.php?rid=2508392&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F58 Conclusions: These findings are highly consistent with our model of how auditory feedback is processed during speaking, where incoming feedback is compared with an efference-copy derived prediction of expected feedback. Thus, the results provide further insights about how speech motor output is controlled, as well as the computational role of auditory cortex in transforming auditory feedback. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2508392 Fri, 12 Jun 2009 23:00:00 +0100 2508392 http://www.medworm.com/index.php?rid=2457281&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F57 Conclusions: The lesion paradigm used here models aspects of the cholinergic deficits associated with Alzheimer's disease and aging. We showed that running still increased the number of newborn cells in the adult hippocampal dentate gyrus in this model of neurodegenerative disease. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2457281 Fri, 05 Jun 2009 04:00:00 +0100 2457281 http://www.medworm.com/index.php?rid=2457282&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F56 Background: Cerebral ischemia is usually characterized by a reduction in local blood flow and metabolism and by disruption of the blood-brain barrier in the infarct region. The formation of oedema and opening of the blood-brain barrier in stroke is associated with enhanced expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Results: Here, we found an infarct volume of 24.8 +/- 2 % and a reduced neurological function after two hours of middle cerebral artery occlusion (MCAO), followed by 48 hours of recirculation in rat. Immunocytochemistry and confocal microscopy revealed enhanced expression of MMP-9, TIMP-1, and phosphorylated ERK1/2 in the smooth muscle cells of the ischemic MCA and associated intracerebral microvessels. The specific MEK1/2 inh... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2457282 Thu, 04 Jun 2009 04:00:00 +0100 2457282 http://www.medworm.com/index.php?rid=2457283&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F55 Conclusions: Our results outline a theoretical mechanism by which brain dynamics may facilitate neuroanatomical self-organization. We find time scale dependent differences between structural and functional networks. These differences are likely to arise from the distinct dynamics of central structural nodes. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2457283 Tue, 02 Jun 2009 04:00:00 +0100 2457283 http://www.medworm.com/index.php?rid=2446538&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F54 Conclusions: TBS does not offer a promising outcome for patients with tinnitus in the presented study. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2446538 Fri, 29 May 2009 04:00:00 +0100 2446538 http://www.medworm.com/index.php?rid=2436939&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F52 Conclusions: The protective effect of exogenous NGF during this systemic circulatory disease seems to occur also by strengthen the effect of endogenous NGF, the synthesis of which is increased by vascular defect and also by the mechanical lesion associated with NGF or even vehicle intraocular delivery. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2436939 Wed, 27 May 2009 04:00:00 +0100 2436939 http://www.medworm.com/index.php?rid=2432583&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F51 Conclusions: Our results support the role of HIV-1-mediated oxidative stress in astrocytic death and the importance of antioxidant compounds in preventing these cellular damages. Moreover, these data indicate that the telomere structure, target for oxidative damage, could be the key sensor of cell apoptosis induced by oxidative stress after HIV infection. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2432583 Fri, 22 May 2009 04:00:00 +0100 2432583 http://www.medworm.com/index.php?rid=2416154&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F50 Conclusions: The effect of brain region has a greater influence on serotonergic gene expression than either genotype or gender. These data add to the growing body of evidence that effects of functional polymorphisms on gene expression in vitro are not observed ex vivo, and provide information that will aid in the design of expression studies of the serotonergic gene system within human post-mortem brain. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2416154 Fri, 15 May 2009 04:00:00 +0100 2416154 http://www.medworm.com/index.php?rid=2416155&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F49 Conclusions: We thus show that G-CSF neuroprotection is at least partially independent of potential systemic effects and provide further evidence that the clinically applicable G-CSF could become a treatment option for both neurodegenerative diseases and glaucoma. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2416155 Thu, 14 May 2009 04:00:00 +0100 2416155 http://www.medworm.com/index.php?rid=2416156&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F48 Conclusions: These results suggest that BDNF protein is rapidly elevated by antidepressant treatments by posttranscriptional mechanisms, and that induction of BDNF mRNA is a slower process. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2416156 Wed, 13 May 2009 04:00:00 +0100 2416156 http://www.medworm.com/index.php?rid=2416158&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F46 Conclusions: The tool is publicly available as a freeware at the address: http://www.bsp.brain.riken.jp/bumptoolbox/toolbox home.html (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2416158 Tue, 12 May 2009 04:00:00 +0100 2416158 http://www.medworm.com/index.php?rid=2416157&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F47 Conclusions: Our MRI in vivo neuropathological findings using two sensitive and unbiased techniques support the hypothesis that alterations in frontostriatal circuitries underlie TS pathology. We suggest that anomalous frontal lobe association and projection fiber bundles cause disinhibition of the cingulate gyrus and abnormal basal ganglia function. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2416157 Tue, 12 May 2009 04:00:00 +0100 2416157 http://www.medworm.com/index.php?rid=2397750&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F43 Background: Studies of adult hippocampal neurogenesis (AHN) in laboratory rodents have raised hopes for therapeutic interventions in neurodegenerative diseases and mood disorders, as AHN can be modulated by physical exercise, stress and environmental changes in these animals. Since it is not known whether cell proliferation and neurogenesis in wild living mice can be experimentally changed, this study investigates the responsiveness of AHN to voluntary running and to environmental change in wild caught long-tailed wood mice (Apodemus sylvaticus). Results: Statistical analyses show that running had no impact on cell proliferation (p=0.44), neurogenesis (p=0.94) or survival of newly born neurons (p=0.58). Likewise, housing in the laboratory has no effect on AHN. In addition, interindividual... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2397750 Wed, 06 May 2009 04:00:00 +0100 2397750 http://www.medworm.com/index.php?rid=2380571&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F42 Conclusions: The results indicate that auditory grouping and the probability distribution of possible patterns within a sequence influence the expectations about upcoming tones, and that the MMN might also be based on global statistical knowledge instead of a local memory trace. The results also show that auditory grouping based on sequential regularities can occur at a much slower presentation rate than previously presumed, and that probability distributions of possible patterns should be taken into account even for the construction of simple oddball sequences. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2380571 Thu, 30 Apr 2009 04:00:00 +0100 2380571 http://www.medworm.com/index.php?rid=2375472&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F39 Conclusion: These results demonstrate that the 'interaction' information of two agents can affect the neural activities in the bilateral occipitotemporal region, on average 300 - 400 ms after the onset of a two-agent BM stimulus, however, the modulation was different between hemispheres: the left hemisphere is more concerned with dynamics, whereas the right hemisphere is more concerned with form information. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2375472 Mon, 27 Apr 2009 04:00:00 +0100 2375472 http://www.medworm.com/index.php?rid=2364576&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F38 Conclusion: Analysis employed in this study successfully segregated four different elements involved in the spatio-temporal dynamics of cortical activations in response to a face stimulus. The results show the responses of MOG and TPJ to be associated with non-specific processes, such as the detection of abrupt changes or exogenous attention. Activity in FG corresponds to a face-specific response recorded by intracranial studies, and that in V1/V2 is related to a change in luminance. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2364576 Fri, 24 Apr 2009 04:00:00 +0100 2364576 http://www.medworm.com/index.php?rid=2357555&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F37 Conclusions: Our results demonstrate that Marlin-1 is expressed in discrete areas of the brain. They also confirm the microtubule association at the ultrastructural level in neurons. Together with the abundance of the protein in dendrites and axons they are consistent with the emerging role of Marlin-1 as an intracellular protein linking the cytoskeleton and transport. Our study constitutes the first detailed description of the cellular and subcellular distribution of Marlin-1 in the brain. As such, it will set the basis for future studies on the functional implications of Marlin-1 in protein trafficking. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2357555 Wed, 22 Apr 2009 04:00:00 +0100 2357555 http://www.medworm.com/index.php?rid=2330163&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F33 Background: Donepezil improves cognitive functions in AD patients. Effects on the brain metabolites N-acetyl-L-aspartate, choline and myo-inositol levels have been reported in clinical studies using this drug. The APP/PS1 mouse coexpresses the mutated forms of human beta-amyloid precursor protein (APP) and mutated human presenilin 1 (PS1). Consequently, the APP/PS1 mouse model reflects important features of the neurochemical profile in humans. In vivo magnetic resonance spectroscopy (1H-MRS) was performed in fronto-parietal cortex and hippocampus (ctx/hipp) and in striatum (str). Metabolites were quantified using the LCModel and the final analysis was done using multivariate data analysis. The aim of this study was to investigate if multivariate data analysis could detect changes in the pa... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330163 Tue, 07 Apr 2009 04:00:00 +0100 2330163 http://www.medworm.com/index.php?rid=2330162&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F34 Conclusions: The results of the present study do not provide evidence for the hypothesis that auditory temporal processing, as measured by the decrement (short-term habituation) of the major auditory evoked component, the N1m wave, is impaired in aging. The differences between these magnetoencephalographic findings and previously published behavioral data might be explained by differences in the experimental setting between the present study and previous behavioral studies, in terms of speech rate, attention, and masking noise. Significantly larger amplitudes of the P1m and N1m waves suggest that the cortical processing of individual sounds differs between younger and older individuals. This result adds to the growing evidence that brain functions, such as sensory processing, motor control... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330162 Tue, 07 Apr 2009 04:00:00 +0100 2330162 http://www.medworm.com/index.php?rid=2330164&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F32 Conclusion: While functional assembly could be demonstrated for all combinations, not all of the specific interactions seen for NR1 isoforms with coexpressed NR2 subunits could be corroborated for NR1 assembly with NR3. Rather, NR3 abates trafficking effects mediated by the NR1 C terminus as well as the N-terminally mediated proton insensitivity. Thus, this study establishes that NR3B overrides important NR1 splice variant-specific receptor properties in NR1/NR3B excitatory glycine receptors. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330164 Mon, 06 Apr 2009 04:00:00 +0100 2330164 http://www.medworm.com/index.php?rid=2330165&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F31 Conclusion: These data provide evidence for bi-directional reduction of IHI during unimanual contractions. During unimanual, sustained contractions of the hand, the contralateral and ipsilateral motor cortices demonstrate reduced inhibition. The data suggest that unimanual movement decreases inhibition bi-directionally across motor hemispheres and offer one explanation for the observation of ipsilateral M1 activity during hand movements. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330165 Sat, 04 Apr 2009 04:00:00 +0100 2330165 http://www.medworm.com/index.php?rid=2330167&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F29 Conclusions: We constructed and characterized a neuron-specific cAMP probe based on Epac1-camps. Using viral gene transfer we showed its efficient expression in organotypic brainstem preparations. Strong fluorescence, resistance to photobleaching and possibility of direct estimation of [cAMP] levels using dual wavelength measurements make the probe useful in studies of neurons and the mechanisms of their plasticity. Epac1-camps was applied to examine the crosstalk between Ca2+ and cAMP signalling and revealed a synergism of actions of these two second messengers. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330167 Fri, 27 Mar 2009 04:00:00 +0100 2330167 http://www.medworm.com/index.php?rid=2330166&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F30 Conclusion: Taken together, these data demonstrated a functional link between the constitutive expression of mPER2 and the intrinsic control of neural stem/progenitor cells proliferation, cell death and neurogenesis in the dentate gyrus of adult mice. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330166 Fri, 27 Mar 2009 04:00:00 +0100 2330166 http://www.medworm.com/index.php?rid=2330168&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F28 Conclusion: In conclusion, our study demonstrates that YB-1 is predominantly expressed in neurons in the adult brain of rats, macaques and humans. Lack of a co-localization with Glut-1 and P-glycoprotein argues against a direct role of YB-1 in the regulation of blood-brain barrier P-glycoprotein. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330168 Thu, 26 Mar 2009 04:00:00 +0100 2330168 http://www.medworm.com/index.php?rid=2330170&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F26 The hippocampus is essential for the synthesis of mammalian declarative memory and a core pathological substrate of Alzheimeras disease (AD), the most common ageing-related dementing disease. Acute bursts in cortisol are associated with transient hippocampal inhibition and retrograde amnesia, while chronic cortisol elevation is associated with hippocampal atrophy. It is suggested that monitoring cortisol levels may help calculate an individualas risk of progressive hippocampal dysfunction. Therefore we created a model of the in silico effects of acute and chronic elevations in plasma cortisol levels on hippocampal activity and atrophy using the systems biology mark-up language (SBML) and challenged the model with in silico biological based interventions to ascertain if cortisol associated ... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330170 Wed, 25 Mar 2009 04:00:00 +0100 2330170 http://www.medworm.com/index.php?rid=2330169&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F27 Conclusions: Based on their functional profiles, the hypothesis is presented that Ncs-1a/Pi4k-beta/Arf1 form a signaling pathway that is required for secretion of molecular components, including Dan and Bmp4, that are required for development of the vestibular apparatus. A second set of NBPs, consisting of Pink1, Hint2, and Slc25a25, are destined for localization in mitochondria. Our findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2330169 Wed, 25 Mar 2009 04:00:00 +0100 2330169 http://www.medworm.com/index.php?rid=2285273&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F25 Conclusions: These results indicate that Cupidin/Homer2 interacts with the dendritic spine actin regulators Cdc42 and Drebrin via its C-terminal and N-terminal domains, respectively, and that it may be involved in spine morphology and synaptic properties. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2285273 Tue, 24 Mar 2009 04:00:00 +0100 2285273 http://www.medworm.com/index.php?rid=2285275&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F23 Conclusion: The results show that cortical reorganization induced by unilateral deafness mainly occurs in subjects with left-sided deafness. This suggests that anatomical and functional plastic changes are more likely to occur in the right than in the left auditory cortex. The possible perceptual correlates of such neurophysiological changes are discussed. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2285275 Mon, 23 Mar 2009 04:00:00 +0100 2285275 http://www.medworm.com/index.php?rid=2285274&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F24 Conclusions The data suggest potential influences of these genes in song learning and/or masculinization of song system morphology, both of which are occurring at this developmental stage. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2285274 Mon, 23 Mar 2009 04:00:00 +0100 2285274 http://www.medworm.com/index.php?rid=2261128&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F21 Conclusions: These results demonstrate that neonates can efficiently learn transitional probabilities or frequencies of co-occurrence between different syllables, enabling them to detect word boundaries and in this way isolate single words out of fluent natural speech. The ability to adopt statistical structures from speech may play a fundamental role as one of the earliest prerequisites of language acquisition. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2261128 Fri, 13 Mar 2009 04:00:00 +0100 2261128 http://www.medworm.com/index.php?rid=2261130&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F19 Conclusion: The findings demonstrate that dietary Na+ deprivation does not change ENaC mRNA expression in rat taste buds, but reduces BDNF mRNA expression in the fungiform taste buds. Given the roles of BDNF in survival of cells and target innervation, our results suggest that dietary Na+ deprivation might lead to a loss of gustatory innervation in the mouse fungiform taste buds. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2261130 Thu, 12 Mar 2009 04:00:00 +0100 2261130 http://www.medworm.com/index.php?rid=2261129&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F20 Conclusions: SCN2A, SCN3A and SCN9A voltage-gated sodium channels are positioned to sense initial depolarizing signals stemming from taste receptor activation and initiate taste cell action potentials. SCN2A, SCN3A and SCN9A gene products likely account for the tetrodotoxin-sensitive sodium currents in taste receptor cells. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2261129 Thu, 12 Mar 2009 04:00:00 +0100 2261129 http://www.medworm.com/index.php?rid=2261131&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F18 Conclusions: Our results show that the development of the intracortical cholinergic system accompanies the cortical rearrangements during the second postnatal week, a crucial stage for the establishment of cortical cytoarchitecture and for synaptogenesis. Although intrinsic ChAT positive cells usually expressed calretinin, they displayed a variable GABAergic phenotype depending on marker and on cortical developmental stage. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2261131 Mon, 09 Mar 2009 04:00:00 +0100 2261131 http://www.medworm.com/index.php?rid=2261132&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F10%2F16 Conclusion: The present study highlights the existence of an inter-donor variability of expression of neural-related markers in human MSC samples that has not previously been described. This donor-related heterogeneity might influence the reproducibility of transdifferentiation protocols as well as contributing to the ongoing controversy about differentiation capacities of MSCs. Therefore, further studies need to consider the differences between donor samples prior to any treatment as well as the possibility of harvesting donor cells that may be inappropriate for transplantation strategies. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=2261132 Tue, 03 Mar 2009 05:00:00 +0100 2261132