MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Neuroscience - Latest articles' source. Tue, 07 Feb 2012 07:05:39 +0100 http://www.medworm.com/index.php?rid=5645044&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F15 Conclusions: The present study has demonstrated changes in functionally classified Abeta low threshold and high threshold DRG neurons in a nerve intact animal model of peripheral neuropathy that demonstrates nociceptive responses to normally innocuous cutaneous stimuli, much the same as is observed in humans with neuropathic pain. We demonstrate further that the peripheral receptive fields of these neurons are more excitable, as are the somata. However, the dorsal roots exhibit a decrease in excitability. Thus, if these neurons participate in neuropathic pain this differential change in excitability may have implications in the peripheral drive that induces central sensitization, at least in animal models of peripheral neuropathic pain, and Abeta sensory neurons may thus contribute to allo... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5645044 Mon, 30 Jan 2012 05:00:00 +0100 5645044 http://www.medworm.com/index.php?rid=5636689&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F14 Conclusions: The results presented here confirm that glutamate and GABA synaptic connectivity develop very differently in the hippocampal CA1 region. Thus, whereas average GABA connectivity is multiple throughout the development, glutamate connectivity is unitary early in development. Our results further suggest that the development of glutamate synaptic connectivity differs markedly between pyramidal cells and GABAergic interneurons in stratum radiatum, such that a given presynaptic glutamatergic cell appears not allowed to increase its connectivity onto the postsynaptic stratum radiatum interneuron, as it may do onto the postsynaptic CA1 pyramidal cell. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5636689 Wed, 25 Jan 2012 05:00:00 +0100 5636689 http://www.medworm.com/index.php?rid=5626074&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F12 Conclusions: It is reported herein that the regulation of markers involved in demyelination and neuroprotection processes occurring during EAE, a well-established MS animal model, is gender- and time-dependent. These findings might contribute to gender- and phase disease-based therapy strategies. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5626074 Tue, 24 Jan 2012 05:00:00 +0100 5626074 http://www.medworm.com/index.php?rid=5626073&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F13 Conclusions: Water immersion reduced short-latency SEP components known to originate in several cortical areas. Attenuation of short-latency SEPs suggests that water immersion influences the cortical processing of somatosensory inputs. Modulation of cortical processing may contribute to the beneficial effects of aquatic therapy.Trial Registration: UMIN-CTR (UMIN000006492) (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5626073 Tue, 24 Jan 2012 05:00:00 +0100 5626073 http://www.medworm.com/index.php?rid=5618160&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F11 Conclusion: These findings suggested that Met and TQ are strong protective agents against ethanol-induced neuronal apoptosis in primary rat cortical neurons. The collective data demonstrated that Met and TQ have the potential to ameliorate ethanol neurotoxicity and revealed a possible protective target mechanism for the damaging effects of ethanol during early brain development. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5618160 Thu, 19 Jan 2012 05:00:00 +0100 5618160 http://www.medworm.com/index.php?rid=5605605&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F10 Conclusion: 5-HT inhibits neuronal Na+/K+ pump activity via 5-HT3R in rat hippocampal CA1 pyramidal neurons. This discloses novel mechanisms for the function of 5-HT in learning and memory, which may be a useful target to benefit these patients with cognitive disorder. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5605605 Thu, 19 Jan 2012 05:00:00 +0100 5605605 http://www.medworm.com/index.php?rid=5594926&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F9 Conclusions: Our results suggest different visual cerebral processes based either on the global shape of well-known objects or on local details of unknown objects. Moreover, the manipulation of an object appears necessary for these dolphins to construct a global representation of an object enabling its immediate categorization for subsequent use. Our experimental results pointed out some cognitive capacities of dolphins which might be crucial for their wild life given their fission-fusion social system and migratory behaviour. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5594926 Thu, 12 Jan 2012 05:00:00 +0100 5594926 http://www.medworm.com/index.php?rid=5579029&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F8 Paired smoking-related and neutral cues elicit enhanced event-related potentials in the brains of smokers compared to non-smokers, providing electrophysiological evidence of higher-order, associative learning which may play a role in addiction. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5579029 Wed, 11 Jan 2012 05:00:00 +0100 5579029 http://www.medworm.com/index.php?rid=5570397&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F6 Conclusions: Key pluripotency genes were controlled by different mechanisms, including the differential enrichment of repressive histone methylation marks. These data provided novel clues regarding the critical role of histone methylation in the maintenance of pluripotency and the determination of cell fate in P19 pluripotent cells. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5570397 Fri, 06 Jan 2012 05:00:00 +0100 5570397 http://www.medworm.com/index.php?rid=5570396&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F7 Conclusions: The enhanced sustained field responses to periodic noises show that cortical sensitivity to periodic sounds is maintained for a wide range of repetition rates. Persistence of periodicity sensitivity below the pitch range suggests that in addition to processing the fundamental frequency of voice, sustained field generators can also resolve low frequency temporal modulations in speech envelope. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5570396 Fri, 06 Jan 2012 05:00:00 +0100 5570396 http://www.medworm.com/index.php?rid=5570400&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F2 Conclusions: This is the first high-throughput microarray study in L. stagnalis, a model of axonal regeneration following CNS injury. We reported that 348 genes were regulated following central nerve injury in adult L. stagnalis and provided the first evidence for the involvement of local C/EBP in neuronal regeneration. Our study demonstrates the usefulness of the large-scale gene profiling approach in this invertebrate model to study the molecular mechanisms underlying the intrinsic regenerative capacity of adult CNS neurons. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5570400 Wed, 04 Jan 2012 05:00:00 +0100 5570400 http://www.medworm.com/index.php?rid=5570399&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F3 The objective was to examine functional connectivity linked to the auditory system in patients with bothersome tinnitus. Activity was low frequency ( (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5570399 Wed, 04 Jan 2012 05:00:00 +0100 5570399 http://www.medworm.com/index.php?rid=5570398&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F4 Conclusions: The present study emphasizes the role of the left UF as candidate WM fiber bundle associated with anxiety-related processes and suggests that fiber bundle volume is a WM measure of particular interest. Moreover, these results substantiate the structural relatedness of UF and amygdala by a non-invasive imaging method. The UF-amygdala complex may be pivotal for the control of trait anxiety. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5570398 Wed, 04 Jan 2012 05:00:00 +0100 5570398 http://www.medworm.com/index.php?rid=5570401&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F1 Conclusion: A split of the afferents from the (first) pair of antennae into separate chemosensory and mechanosensory components is also typical for Crustacea and Hexapoda, but this set of characters is absent in Chelicerata. We suggest that this character set strongly supports the Mandibulata hypothesis (Myriapoda + (Crustacea + Hexapoda)) as opposed to the Myriochelata concept (Myriapoda + Chelicerata). The evolutionary implications of our findings, particularly the plasticity of glomerular shape, are discussed. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5570401 Tue, 03 Jan 2012 05:00:00 +0100 5570401 http://www.medworm.com/index.php?rid=5521735&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F128 Conclusion: This study showed that pitch changes, stripped of lexical information, are mainly processed by the right cerebral hemisphere, whilst the processing of analogous, matched, lexical pitch change is preferentially left sided. These findings, showing hemispherical differentiation of processing based on stimulus complexity, are in accord with a 'task dependent' hypothesis of pitch processing. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5521735 Tue, 20 Dec 2011 05:00:00 +0100 5521735 http://www.medworm.com/index.php?rid=5521734&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F129 Conclusions: These results suggest that there are two parallel cholinergic septo-hippocampal pathways that may have different functions. The significance of nestin expressing in functional neurons has been discussed. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5521734 Tue, 20 Dec 2011 05:00:00 +0100 5521734 http://www.medworm.com/index.php?rid=5521737&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F126 Conclusions: These results indicate that Kal7 is an essential and selective modulator of NMDA receptor-dependent synaptic plasticity in the hippocampus. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5521737 Mon, 19 Dec 2011 05:00:00 +0100 5521737 http://www.medworm.com/index.php?rid=5521736&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F127 Conclusions: Our results indicate that NET causes an increase of activity associated with cortical top-down regulation of attention towards aversive pictures. The increase of attention allocation to potential threat cues might allow treated patients to re-appraise the actual danger of the current situation and, thereby, reducing PTSD symptoms.Registration of the clinical trialNumber: NCT00563888, Name: "Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims" ULR: http://www.clinicaltrials.gov/ct2/show/NCT00563888 (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5521736 Mon, 19 Dec 2011 05:00:00 +0100 5521736 http://www.medworm.com/index.php?rid=5502563&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F125 Conclusion: Our data indicate that BER decreases the production of beta-amyloid40/ 42 by inhibiting the expression of BACE via activation of the ERK1/2 pathway.Key words: Alzheimer's disease, berberine, beta-amyloid40/42, beta-secretase, extracellular signal-regulated kinase1/2 (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5502563 Mon, 12 Dec 2011 05:00:00 +0100 5502563 http://www.medworm.com/index.php?rid=5493246&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F124 Conclusions: These results suggest the negative consequences of chemotherapy on brain function and that anti-cancer drugs can adversely affect the self-renewal potential of neural progenitor cells and also chromatin remodeling in the hippocampus. The significance of our findings lie on the possible usefulness of animal models in addressing the clinical phenomenon of 'chemobrain.' (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5493246 Fri, 09 Dec 2011 05:00:00 +0100 5493246 http://www.medworm.com/index.php?rid=5466652&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F123 Conclusions: Our behavioral findings are consistent with increases in IL-1beta and IL-18 that have been previously shown to correlate with spatial learning deficits. Probenecid reduced activated caspase-1 and ameliorated spatial learning deficits in aged rats. Thus, aging processes stimulate activation of the NLRP1 inflammasome and secretion of IL-1beta and IL-18 that may contribute to age-related cognitive decline in the growing elderly population. Moreover, probenecid may be potentially useful as a therapy to improve cognitive outcomes in the aging population. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5466652 Thu, 01 Dec 2011 05:00:00 +0100 5466652 http://www.medworm.com/index.php?rid=5466653&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F122 Conclusions: Different brain networks are involved in vocoded sound processing of intelligible speech, unintelligible speech, and non-vocal sounds. The greatest differences are between speech and environmental sounds, which could be related to the distinctive temporal structure of speech sounds. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5466653 Wed, 30 Nov 2011 05:00:00 +0100 5466653 http://www.medworm.com/index.php?rid=5448362&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F121 Conclusions: This study differs from previous approaches by relating dynamics in the resting state to neural responsiveness in the activation state. Our analyses suggest that the neural characteristics carried by resting brain dynamics modulate the earlier/automatic stage of target detection. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5448362 Thu, 24 Nov 2011 05:00:00 +0100 5448362 http://www.medworm.com/index.php?rid=5438792&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F120 Conclusions: TRPM8 may play different roles in mechanical allodynia, cold and thermal hyperalgesia that develop after nerve injury, and it is a very promising research direction for the development of new therapies for chronic neuroapthic pain. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5438792 Wed, 23 Nov 2011 05:00:00 +0100 5438792 http://www.medworm.com/index.php?rid=5429249&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F119 Conclusions: TRENTOOL is an implementation of transfer entropy and mutual information analysis that aims to support the user in the application of this information theoretic measure. TRENTOOL is implemented as a MATLAB toolbox and available under an open source license (GPL v3). For the use with neural data TRENTOOL seamlessly integrates with the popular FieldTrip toolbox. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5429249 Fri, 18 Nov 2011 05:00:00 +0100 5429249 http://www.medworm.com/index.php?rid=5419633&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F118 Conclusion: The present study supplies a detailed morphological description of VAMP-2, SNAP-25A/B and syntaxin-1 in the different types of glutamatergic and GABAergic synapses of the rat cerebellar cortex. The examined SNARE proteins characterize most of glutamatergic synapses and only one type of GABAergic synapses. In the subpopulations of glutamatergic and GABAergic synapses lacking the SNARE protein isoforms examined, alternative mechanisms for regulating trafficking of synaptic vesicles may be hypothesized, possibly mediated by different isoforms or homologous proteins. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5419633 Thu, 17 Nov 2011 05:00:00 +0100 5419633 http://www.medworm.com/index.php?rid=5419634&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F117 Conclusions: Gene expression studies validate several candidates generated through database studies of possible FTO-interactors. We speculate about a wider functional role for FTO in the context of current, and recent findings, such as in extracellular ligand-induced neuronal plasticity via NTRK2/BDNF, possibly via interaction with the transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta). (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5419634 Wed, 16 Nov 2011 05:00:00 +0100 5419634 http://www.medworm.com/index.php?rid=5419636&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F115 Conclusions: Our results indicate that BLA-PFC pathways inhibited PFC nociceptive cell activities and that the DA system modifies the BLA-PFC regulatory function. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5419636 Tue, 15 Nov 2011 05:00:00 +0100 5419636 http://www.medworm.com/index.php?rid=5419635&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F116 Conclusions: NM is recognized by DCs in vitro and triggers their maturation. If operative in vivo, this would allow the DC-mediated transport and presentation of SN antigens to the adaptive immune system, leading to autoimmmunity in susceptible individuals. Our data provide a rationale for an autoimmune-based pathomechanism of PD with NM as the initial trigger. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5419635 Tue, 15 Nov 2011 05:00:00 +0100 5419635 http://www.medworm.com/index.php?rid=5405165&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F113 Background: Thrombolysis after acute ischemic stroke has only proven to be beneficial in a subset of patients. The soluble recombinant analogue of human thrombomodulin, Solulin, was studied in an in vivo rat model of acute ischemic stroke. Methods: Male SD rats were subjected to 2hrs of transient middle cerebral artery occlusion (tMCAO). Rats treated with Solulin intravenously shortly before reperfusion were compared to rats receiving normal saline i.v. with respect to infarct volumes, neurological deficits and mortality. Gene expression of IL-6, IL-1beta, TNF-alpha, MMP-9, CD11B and GFAP were semiquantitatively analyzed by rtPCR of the penumbra. Results: 24hrs after reperfusion, rats were neurologically tested, euthanized and infarct volumes determined. Solulin significantly reduced mean ... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5405165 Mon, 14 Nov 2011 05:00:00 +0100 5405165 http://www.medworm.com/index.php?rid=5405164&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F114 Conclusion: These results suggest a neuroprotective effect of statins in the inner ear, mediated by reduced 3-hydroxy-3-methylglutaryl-coenzyme A reductase metabolism and Akt activation. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5405164 Mon, 14 Nov 2011 05:00:00 +0100 5405164 http://www.medworm.com/index.php?rid=5398259&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F112 Conclusions: This study demonstrates the detailed expression of CGRP and its receptor components within STN in the brainstem and in the spinal cord at C1-level, and shows the possibility of CGRP acting postjunctionally in these areas putatively involved in primary headaches. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5398259 Thu, 10 Nov 2011 05:00:00 +0100 5398259 http://www.medworm.com/index.php?rid=5378170&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F111 Conclusions: It is concluded that P2X4 which is constitutively expressed by AMC in postnatal rats was enhanced in hypoxia. Hypoxia induced increase in IL-1beta and TNF-alpha expression was reversed by 2' , 3' -0-(2, 4, 6-Trinitrophenyl) adenosine 5' -triphosphate suggesting that P2X4 mediates ATP induced AMC activation and its production of proinflammatory cytokines. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5378170 Fri, 04 Nov 2011 04:00:00 +0100 5378170 http://www.medworm.com/index.php?rid=5378171&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F110 Conclusions: Sleep-stage specific distributions of REM in mice correspond to human REM density during sleep. REM density, now also assessable in animal models through our approach, is increased in humans after acute stress, during PTSD and in depression. This relationship can now be exploited to match animal models more closely to clinical situations, especially in animal models of depression. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5378171 Wed, 02 Nov 2011 04:00:00 +0100 5378171 http://www.medworm.com/index.php?rid=5378173&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F108 Conclusion: We found that the APT has different characteristics, including less directionality, fewer neural fibers, and less origin from the primary motor cortex than the PT. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5378173 Tue, 01 Nov 2011 04:00:00 +0100 5378173 http://www.medworm.com/index.php?rid=5378172&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F109 Background: Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS upregulates endothelin receptors with increased cerebrovascular contraction via the Raf/extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK) pathway. Results: Rats were exposed to SHS for up to 8 weeks. The cerebral artery vasoconstriction was recorded by a sensitive myograph. The mRNA and protein expressions for endothelin receptors in cerebral arteries were studied by real-time PCR and Western blot. Compared to fresh air exposed rats, cerebral arteries from SHS rats exhibited stronger contractile responses (P (So... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5378172 Tue, 01 Nov 2011 04:00:00 +0100 5378172 http://www.medworm.com/index.php?rid=5356856&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F106 Conclusions: The present findings suggest that RA may exert beneficial effects against Amyloid burden and harmful effects on microvascular pathology in AD. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5356856 Thu, 27 Oct 2011 04:00:00 +0100 5356856 http://www.medworm.com/index.php?rid=5356855&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F107 Conclusion: These results provide evidence for a role of the ERK1/2 pathway in regulation of expression of cerebrovascular SMC receptors. It is suggested that raf inhibition may reduce late cerebral ischemia after SAH and provides a realistic time window for therapy. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5356855 Thu, 27 Oct 2011 04:00:00 +0100 5356855 http://www.medworm.com/index.php?rid=5344806&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F105 Conclusion: Taken together, our results indicate that a relatively long lasting form of adaptation occurs within the axon terminals of the ORNs in the antennal lobes, which depends on intracellular Ca2+-stores, attributable to a positive feedback through the GABAergic synapses. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5344806 Mon, 24 Oct 2011 04:00:00 +0100 5344806 http://www.medworm.com/index.php?rid=5344807&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F104 Conclusions: These results suggest that two genetic loci control the organization of syllable sequences. These loci were occupied by the staccato and chevron-wave alleles in the B6 and 129 mouse strains, respectively. Recombination of these alleles might lead to the diversity of USV patterns produced by mice. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5344807 Fri, 21 Oct 2011 04:00:00 +0100 5344807 http://www.medworm.com/index.php?rid=5322305&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F102 Background: Caspase-3 is one of the most downstream enzymes activated in the apoptotic pathway. In caspase-3 deficient mice, loss of cochlear hair cells and spiral ganglion cells coincide closely with hearing loss. In contrast with the auditory system, details of the vestibular phenotype have not been characterized. Here we report the vestibular phenotype and inner ear anatomy in the caspase-3 deficient (Casp3-/-) mouse strain. Results: Average ABR thresholds of Casp3-/- mice were significantly elevated (P (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5322305 Wed, 12 Oct 2011 04:00:00 +0100 5322305 http://www.medworm.com/index.php?rid=5322304&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F103 Conclusions: In summary, NRG1 stimulation of the ErbB4 receptor exerts a sustained [Ca2+]i increase in ST14A neural progenitors; NRG1-induced migration is Ca2+-dependent and can be positively modulated by activation of the NMDA receptor. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5322304 Wed, 12 Oct 2011 04:00:00 +0100 5322304 http://www.medworm.com/index.php?rid=5322307&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F100 Conclusions: NeuriteQuant is a freely available open-source tool for the automated analysis and effective review of large-scale high-content screens. It is especially well suited to quantify the effect of experimental manipulations on physiologically relevant neuronal cultures or brain sections that display a high degree of complexity and overlap among neurites or other cellular structures. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5322307 Tue, 11 Oct 2011 04:00:00 +0100 5322307 http://www.medworm.com/index.php?rid=5322306&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F101 Background: Trail-making tests, such as the Concept Shifting Task (CST), can be used to test the effects of treatment on cognitive performance over time in various neuropsychological disorders. However, cognitive performance in such experimental designs might improve as a result of the practice obtained during repeated testing rather than the treatment itself. The current study investigated if practice affects the accuracy and duration of performance on the repeatedly administered Concept Shifting Task modified to make it resistant to practice (mCST). The mCST was administered to 54 healthy participants twice a day, before and after a short break, for eight days. Results. The ANOVA and meta-analysis showed that there was no improvement in the mCST accuracy on the last vs. the first trial (... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5322306 Tue, 11 Oct 2011 04:00:00 +0100 5322306 http://www.medworm.com/index.php?rid=5302462&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F98 Conclusion: The benign outcome of proliferative reactive Muller gliosis suggests that reactive glia display context-dependent, graded and dynamic phenotypes and that reactivity in itself is not necessarily detrimental to neuronal function. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5302462 Mon, 10 Oct 2011 04:00:00 +0100 5302462 http://www.medworm.com/index.php?rid=5302461&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F99 Conclusion: Smooth muscle cells expressing Nestin and Nkx6.1 is the main cell population derived from culturing human spinal cord cells in adherent conditions with serum. Mineralization of these cells in vitro could represent a valuable model for studying calcifications of CNS vessels which are observed in pathological situations or as part of the normal aging. In addition, long term propagation of these cells will allow the study of their interaction with other CNS cells and their implication in scar formation during spinal cord injury. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5302461 Mon, 10 Oct 2011 04:00:00 +0100 5302461 http://www.medworm.com/index.php?rid=5294710&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F97 Conclusions: Hirano bodies are not lethal and appear to have little or no effect on histology and tissue organization. Hirano bodies do modulate synaptic plasticity and exert clearly discernable effects on LTP and paired-pulse paradigms. This model system will allow us to investigate the impact of Hirano bodies in vivo, the pathways for formation and degradation of Hirano bodies, and whether Hirano bodies promote or modulate development of pathology and disease progression. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5294710 Thu, 06 Oct 2011 04:00:00 +0100 5294710 http://www.medworm.com/index.php?rid=5282804&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F96 Conclusions: We concluded, therefore, that ATP- and SUC-sensitive Ca2+ transients appear to represent a signalling layer independent of NAc neurons. This previously unrecognised glial action of SUC, a major cellular energy metabolite, may play a role in linking metabolism to Ca2+ signalling in astrocytic networks under physiological and pathological conditions such as exercise and metabolic diseases. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5282804 Mon, 03 Oct 2011 04:00:00 +0100 5282804 http://www.medworm.com/index.php?rid=5270929&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F95 Conclusions These data demonstrated that Asb-4 co-localizes and interacts with IRS4 in hypothalamic neurons. The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5270929 Wed, 28 Sep 2011 04:00:00 +0100 5270929 http://www.medworm.com/index.php?rid=5258239&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F93 Conclusions: Our data indicate possible DGC involvement in the process of cytoskeletal remodeling in neurons. The identification of new components that interact with the DGC not only helps to dissect the mechanism of axon guidance and eye neuron differentiation but also provides a great opportunity for understanding the signaling mechanisms by which the cell surface receptor Dg communicates via Dys with the actin cytoskeleton. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5258239 Mon, 26 Sep 2011 04:00:00 +0100 5258239 http://www.medworm.com/index.php?rid=5258238&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F94 Conclusions: Native-born HA residents generally showed reduced cerebrovascular reactivity as demonstrated in the hemodynamic response during a visual cue guided maximum inspiration task conducted with BOLD-fMRI. This effect was particularly manifested among brain regions that are typically involved in cerebral modulation of respiration. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5258238 Mon, 26 Sep 2011 04:00:00 +0100 5258238 http://www.medworm.com/index.php?rid=5258240&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F92 Conclusion: Our results have shown that loss of endothelial viability as well as BBB function and integrity caused by TS exposure can be prevented or at least reduced by normal physiologic concentrations of antioxidant vitamins in vitro. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5258240 Sat, 24 Sep 2011 04:00:00 +0100 5258240 http://www.medworm.com/index.php?rid=5247663&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F90 Conclusion: The present data show that ATP induces NFAT-dependent changes in gene expression in PC12 cells by acting on P2X receptors. Maximal NFAT activation depends on both depolarisation-induced calcium influx and store-operated calcium entry and requires the activity of the protein phosphatase calcineurin and the mitogen-activated protein kinase cascade. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5247663 Fri, 23 Sep 2011 04:00:00 +0100 5247663 http://www.medworm.com/index.php?rid=5247662&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F91 Conclusions: These findings indicate that, under resting conditions, microglia from mutant SOD1 transgenic mice have a reduced capacity to elicit physiological responses following tissue disturbances and that higher levels of stimulatory signals, and/or prolonged stimulation may be necessary to initiate these responses. Overall, resting mutant SOD1-overexpressing microglia may have reduced capacity to function as sensors of disturbed tissue/cellular homeostasis in the CNS and thus have reduced neuroprotective function. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5247662 Fri, 23 Sep 2011 04:00:00 +0100 5247662 http://www.medworm.com/index.php?rid=5205498&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F89 Conclusions: These findings reveal that somatostatin receptors demonstrate specific expression in HCs and supporting cells of the mouse cochlea, and that absence of SST1 alters the expression of SST2. This specific expression pattern suggests that somatostatin receptors may have important functional roles in the inner ear. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5205498 Tue, 06 Sep 2011 04:00:00 +0100 5205498 http://www.medworm.com/index.php?rid=5181023&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F88 Growth hormone significantly increased cell proliferation in the zebrafish inner ear and was overexpressed after acoustic trauma suggesting that hair cell regeneration may be accelerated through treatment with growth hormone. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5181023 Thu, 01 Sep 2011 23:00:00 +0100 5181023 http://www.medworm.com/index.php?rid=5158130&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F87 Conclusions: Our results suggest that activated astrocytes depress the release probability via two different mechanisms; by depression of vesicular release probability only at inactive synapses and by imposing a delay in the recovery of the primed pool of vesicles following depletion. These mechanisms restrict the expression of the astrocyte-mediated depression to temporal windows that are typical for synaptic burst activity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5158130 Tue, 23 Aug 2011 23:00:00 +0100 5158130 http://www.medworm.com/index.php?rid=5158131&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F86 Conclusion: Our results point to a possible role for extracellular nucleotides in mediating intercellular communication between the neurons and sustentacular cells of the olfactory epithelium in response to odorant exposure. Maintenance of extracellular ionic gradients and metabolism of noxious chemicals by sustentacular cells may therefore be regulated in an odorant-dependent manner by olfactory sensory neurons. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5158131 Sun, 21 Aug 2011 23:00:00 +0100 5158131 http://www.medworm.com/index.php?rid=5138382&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F85 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5138382 Tue, 16 Aug 2011 23:00:00 +0100 5138382 http://www.medworm.com/index.php?rid=5138383&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F84 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5138383 Mon, 15 Aug 2011 23:00:00 +0100 5138383 http://www.medworm.com/index.php?rid=5118256&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F83 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5118256 Wed, 10 Aug 2011 23:00:00 +0100 5118256 http://www.medworm.com/index.php?rid=5118257&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F82 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5118257 Tue, 09 Aug 2011 23:00:00 +0100 5118257 http://www.medworm.com/index.php?rid=5107161&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F81 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5107161 Sun, 07 Aug 2011 23:00:00 +0100 5107161 http://www.medworm.com/index.php?rid=5095365&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F80 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5095365 Wed, 03 Aug 2011 23:00:00 +0100 5095365 http://www.medworm.com/index.php?rid=5095367&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F78 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5095367 Tue, 02 Aug 2011 23:00:00 +0100 5095367 http://www.medworm.com/index.php?rid=5095366&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F79 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5095366 Tue, 02 Aug 2011 23:00:00 +0100 5095366 http://www.medworm.com/index.php?rid=5085772&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F77 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5085772 Sun, 31 Jul 2011 23:00:00 +0100 5085772 http://www.medworm.com/index.php?rid=5077366&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F75 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5077366 Thu, 28 Jul 2011 23:00:00 +0100 5077366 http://www.medworm.com/index.php?rid=5077365&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F76 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5077365 Thu, 28 Jul 2011 23:00:00 +0100 5077365 http://www.medworm.com/index.php?rid=5069160&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F73 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5069160 Tue, 26 Jul 2011 23:00:00 +0100 5069160 http://www.medworm.com/index.php?rid=5069159&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F74 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5069159 Tue, 26 Jul 2011 23:00:00 +0100 5069159 http://www.medworm.com/index.php?rid=5057628&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F72 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5057628 Thu, 21 Jul 2011 23:00:00 +0100 5057628 http://www.medworm.com/index.php?rid=5049788&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F70 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5049788 Sun, 17 Jul 2011 23:00:00 +0100 5049788 http://www.medworm.com/index.php?rid=5049787&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F71 ${item.shortDescription} (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5049787 Sun, 17 Jul 2011 23:00:00 +0100 5049787 http://www.medworm.com/index.php?rid=5035976&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F68 Conclusions: All the results demonstrated this collagen/PCL nerve conduit with tailored degradation rate fabricated by electrospinning could be an efficient alternative to autograft for peripheral nerve regeneration research. Due to its advantage of high surface area for cell attachment, it is believed that this electrospun nerve conduit could find more application in cell therapy for nerve regeneration in future, to further improve functional regeneration outcome especially for longer nerve defect restoration. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5035976 Thu, 14 Jul 2011 23:00:00 +0100 5035976 http://www.medworm.com/index.php?rid=5035975&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F69 Conclusions: These results suggest that in sympathetic neurons, MEK-ERK signalling negatively regulates bim expression via the 3' UTR and that this regulation is likely to be at the level of transcription. This data provides further insight into the different mechanisms by which survival signalling pathways regulate bim expression in neurons. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5035975 Thu, 14 Jul 2011 23:00:00 +0100 5035975 http://www.medworm.com/index.php?rid=5027564&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F67 Conclusion: This study demonstrated that CART could promote the differentiation of BM-MSCs into neural cells through increasing neurofactors, including BNDF and NGF. Combined application of CART and BM-MSCs may be a promising cell-based therapy for neurological diseases. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5027564 Wed, 13 Jul 2011 23:00:00 +0100 5027564 http://www.medworm.com/index.php?rid=5018883&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F66 Conclusions: The deactivation of the caudate nucleus during failure is in accordance with its role in reward-prediction error: it occurred whenever subject missed an expected reward (being eliminated rather than eliminating the opponent). We found no indication that violence events were directly rewarding for the players. We addressed subjective evaluations of affect change due to gameplay to study the reward system. Subjects reporting greater negative affect after playing the game had less rTP activity associated with failure. The rTP may therefore be involved in evaluating the failure events in a social context, to regulate the players' mood. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5018883 Mon, 11 Jul 2011 23:00:00 +0100 5018883 http://www.medworm.com/index.php?rid=5018884&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F65 Conclusions: Altogether these findings indicate that Myosin VI is important for proper synaptic function and morphology. Myosin VI may be functioning as an anchor to tether vesicles to the bouton periphery and thereby, participating in the regulation of synaptic vesicle mobilization during synaptic transmission. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=5018884 Sun, 10 Jul 2011 23:00:00 +0100 5018884 http://www.medworm.com/index.php?rid=4984147&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F64 Conclusion: IGF1R in neuronal cells is critically important for their survival following H/I injury, and IGF-upregulated expression of neuronal cIAP-1 and XIAP likely in part contributes to IGF-IGF1R protection against neuronal apoptosis following H/I injury. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4984147 Wed, 29 Jun 2011 23:00:00 +0100 4984147 http://www.medworm.com/index.php?rid=4984148&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F63 Conclusions: These results suggest that cortical gene transcription is responsive to learning in the aged mouse, and support a distributed hypothesis of memory storage across multiple cortical compartments. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4984148 Tue, 28 Jun 2011 23:00:00 +0100 4984148 http://www.medworm.com/index.php?rid=4975515&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F62 Conclusions: This study explores the flies' ability to track odor plumes that are temporally intermittent. We were surprised to find that the perceptual critical fusion limit, determined behaviorally, is strongly dependent on odor identity. Antennal field potential recordings indicate that peripheral processing of temporal cues faithfully follow rapid odor transients above the rates that can be resolved behaviorally. These results indicate that (1) higher order circuits create a perceptually continuous signal from an intermittent sensory one, and that (2) this transformation varies with odorant rather than being constrained by sensory-motor integration, thus (3) offering an entry point for examining the mechanisms of rapid olfactory decision making in an ecological context. (Source: BMC Ne... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4975515 Sun, 26 Jun 2011 23:00:00 +0100 4975515 http://www.medworm.com/index.php?rid=4968150&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F61 Conclusion BMMCs and G-CSF co-administration exhibits synergistic beneficial effect over time. This effect could be at least partially related to increased proliferation and differentiation of bone marrow stem cells and enhanced host brain regeneration and functional recovery. The results suggest that G-CSF can increase the therapeutic efficacy of BMMCs transplantation in an experimental mouse model of cerebral ischemia. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4968150 Thu, 23 Jun 2011 23:00:00 +0100 4968150 http://www.medworm.com/index.php?rid=4968152&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F59 Conclusion: The findings indicate that iron deposition around vessels can occur independently of inflammation providing evidence against the hypothesis that iron deposits account for inflammatory cell infiltrates observed in MS. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4968152 Wed, 22 Jun 2011 23:00:00 +0100 4968152 http://www.medworm.com/index.php?rid=4968151&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F60 Whether iron deposition is an epiphenomenon of the multiple sclerosis (MS) disease process or may play a primary role in triggering inflammation and disease development remains unclear at this time, and should be studied at the early stages of disease pathogenesis. However, it is difficult to study the relationship between iron deposition and inflammation in early MS due to the delay between the onset of symptoms and diagnosis, and the poor availability of tissue specimens. In a recent article published in BMC Neuroscience, Williams et al. investigated the relationship between inflammation and iron deposition using an original animal model labeled as "cerebral experimental autoimmune encephalomyelitis" , which develops CNS perivascular iron deposits. However, the relative contribution of i... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4968151 Wed, 22 Jun 2011 23:00:00 +0100 4968151 http://www.medworm.com/index.php?rid=4959819&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F58 Conclusion: The present experimental study confirms end-to-side neurorrhaphy as an alternative method for reconstructing severed peripheral nerves. CNTF promotes motor reinnervation of the MCN stump after its end-to-side neurorrhaphy with ulnar nerve and improves functional recovery of the biceps brachii muscle. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4959819 Tue, 21 Jun 2011 23:00:00 +0100 4959819 http://www.medworm.com/index.php?rid=4933509&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F56 Conclusions: The ability to visualize functionally active tracts has strong implications for the basic scientific study of connectivity and the clinical assessment of white matter disease. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4933509 Mon, 13 Jun 2011 23:00:00 +0100 4933509 http://www.medworm.com/index.php?rid=4933508&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F57 Conclusions: The analysis of sNPF receptor immunolocalization shows that the sNPF signaling cascade may be involved in diverse functions, and the sNPF peptide(s) may act in the brain as neurotransmitter(s) or neuromodulator(s), and in the ovaries as neurohormone(s). To our knowledge, this is the first report of the cellular localization of a sNPF receptor on the brain and ovaries of adult insects. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4933508 Mon, 13 Jun 2011 23:00:00 +0100 4933508 http://www.medworm.com/index.php?rid=4920846&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F55 Conclusions: Face discrimination learning produces significant increases in both theta amplitude and the strength of theta-gamma coupling in the inferotemporal cortex which are correlated with behavioral performance. A network model which can reproduce these changes suggests that a key function of such learning-evoked alterations in theta and theta-nested gamma activity may be increased temporal desynchronization in neuronal firing leading to optimal timing of inputs to downstream neural networks potentiating their responses. In this way learning can produce potentiation in neural networks simply through altering the temporal pattern of their inputs. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4920846 Wed, 08 Jun 2011 23:00:00 +0100 4920846 http://www.medworm.com/index.php?rid=4911147&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F54 Conclusions: Findings of the present study suggest that the brain utilizes the motor predictions (efference copies) to determine the source of incoming stimuli and maximally suppresses the auditory responses to unaltered feedback of self-vocalizations. The reduction of suppression for 50, 100 and 200 cents and its elimination for 400 cents pitch-shifted voice auditory feedback support the idea that motor-driven suppression of voice feedback leads to distinctly different sensory neural processing of self vs. non-self vocalizations. This characteristic may enable the audio-vocal system to more effectively detect and correct for unexpected errors in the feedback of self-produced voice pitch compared with externally-generated sounds. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4911147 Sun, 05 Jun 2011 23:00:00 +0100 4911147 http://www.medworm.com/index.php?rid=4883192&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F52 Conclusions: The present evidence indicated that EGCG can reduce NADPH-d/nNOS reactivity and thus may enhance motor neuron survival time following peripheral nerve injury. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4883192 Tue, 31 May 2011 23:00:00 +0100 4883192 http://www.medworm.com/index.php?rid=4883193&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F51 Conclusion: Previous studies have shown that the amino acid at this position within loop D is a key determinant of neonicotinoid binding to nAChRs and this amino acid change confers a vertebrate-like character to the insect nAChR receptor and results in reduced sensitivity to neonicotinoids. The discovery of the mutation at this position and its association with the reduced affinity of the nAChR for imidacloprid is the first example of field-evolved target-site resistance to neonicotinoid insecticides and also provides further validation of exisiting models of neonicotinoid binding and selectivity for insect nAChRs. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4883193 Mon, 30 May 2011 23:00:00 +0100 4883193 http://www.medworm.com/index.php?rid=4871692&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F49 Conclusion: In conclusion, it is suggested that downregulation of Nox-2 and overexpression of MKP-1 that regulate ROS and NO may form the potential therapeutic strategy for the treatment of neuroinflammation in neurodegenerative diseases. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4871692 Wed, 25 May 2011 23:00:00 +0100 4871692 http://www.medworm.com/index.php?rid=4871691&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F50 Conclusion: SAHA and sodium butyrate directly regulate cdk inhibitor transcription to control cell cycle progression in adult mouse NSCs. HDAC inhibition results in G1 arrest in adult mouse NSCs and transcriptional changes associated with activation of neuronal lineage commitment programs and a reduction of stem/progenitor state. Changes in differentiated cell state in adult mouse NSCs treated with HDACi under proliferation culture conditions suggests an intrinsic relationship between multipotency, cell cycle progression and HDAC activity in these cells. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4871691 Wed, 25 May 2011 23:00:00 +0100 4871691 http://www.medworm.com/index.php?rid=4862216&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F48 Conclusions: Although deaf learners have learned German as an L2 mainly via the visual modality they seem to engage comparable processing mechanisms as hearing L2 learners. Thus, the data underscore the modality transcendence of language. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4862216 Tue, 24 May 2011 23:00:00 +0100 4862216 http://www.medworm.com/index.php?rid=4862217&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F47 Conclusions: We have identified that the level of catecholamines and serotonin is differentially affected in Mecp2-/y brain areas in a time-dependent fashion. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4862217 Mon, 23 May 2011 23:00:00 +0100 4862217 http://www.medworm.com/index.php?rid=4847696&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F46 Conclusion: Bioinformatic analysis complemented by functional analysis of the DRD4 gene locus has identified a) a strong enhancer that functions in neurons and b) a transcription factor that can modulate the function of that enhancer. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4847696 Thu, 19 May 2011 23:00:00 +0100 4847696 http://www.medworm.com/index.php?rid=4840942&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F45 Conclusions: Based on these findings, our results indicate that the efficiency of iTMS strongly depends on the individual choice of the IPI and that parameter optimization of the conventional iTMS1.5ms protocol might improve the outcome of this novel non-invasive brain stimulation technique. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4840942 Tue, 17 May 2011 23:00:00 +0100 4840942 http://www.medworm.com/index.php?rid=4828622&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F44 Conclusions: These results indicate that a new neural representation can be rapidly established between auditory and visual modalities. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4828622 Sat, 14 May 2011 23:00:00 +0100 4828622 http://www.medworm.com/index.php?rid=4820499&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F42 Conclusion The decrease of CSF Abeta42 seems to occur independently of the surgical hydrocephalus aetiology. This suggests that a CSF reduced turnover may play an important role in the decrease of CSF Abeta42 concentration. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4820499 Thu, 12 May 2011 23:00:00 +0100 4820499 http://www.medworm.com/index.php?rid=4820498&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F43 Conclusion: These observations imply that Lgi1 may have a role in establishing normal brain architecture and neuronal functions during brain development suggesting that it may be involved in neurogenesis and neuronal plasticity, which become more specifically defined in the adult animal. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4820498 Thu, 12 May 2011 23:00:00 +0100 4820498 http://www.medworm.com/index.php?rid=4812848&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F41 Conclusions: These results indicate that although the inhibitory effect of MOR activation on presynaptic GABA release is similar in both neuropathic and normal rats, neuropathic pain may inhibit endogenous analgesia in the PAG through an increase in presynaptic GABA release. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4812848 Wed, 11 May 2011 23:00:00 +0100 4812848 http://www.medworm.com/index.php?rid=4812850&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F39 Conclusions: The presence analysis reveals the new localization of p75NTR in the choroid plexus and, the distribution mainly in the cytoplasm and cerebrospinal fluid (CSF) side of the epithelial cells. We propose that p75NTR receptor plays a role in the survival pathways and A-induced cell death. These data suggest that p75NTR dysfunction play an important role in the pathogenesis of brain diseases. The importance and novelty of this expression expands a new role of p75NTR. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4812850 Tue, 10 May 2011 23:00:00 +0100 4812850 http://www.medworm.com/index.php?rid=4812849&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F40 Conclusions: Genomic and proteomic analyses are currently used to examine BBB function in healthy and diseased brain and characterize this dynamic interface. In this study we showed that SS plays a key role in promoting the differentiation of vascular endothelial cells into a truly BBB phenotype. SS affected multiple aspect of the endothelial physiology spanning from tight junctions formation to cell division as well as the expression of multidrug resistance transporters. BBB dysfunction has been observed in many neurological diseases, but the causes are generally unknown. Our study provides essential insights to understand the role played by SS in the BBB formation and maintenance. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4812849 Tue, 10 May 2011 23:00:00 +0100 4812849 http://www.medworm.com/index.php?rid=4812851&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F38 Conclusion: In conclusion, results of this study suggest that long-term primary CNS culture is a viable model for the study of basic mechanisms and effective methods to decelerate the process of neuronal senescence. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4812851 Mon, 09 May 2011 23:00:00 +0100 4812851 http://www.medworm.com/index.php?rid=4802063&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F37 Conclusions: This new imaging assay provides a powerful method to analyze directly development of placode-derived sensory neurons and subsequent ganglia formation for the first time in amniotes. Viewing placode development in a head cross-section provides a vantage point from which it is possible to study comprehensive events in placode formation, from differentiation, cell ingression to ganglion assembly. Understanding how placodal neurons form may reveal a new mechanism of neurogenesis distinct from that in the central nervous system and provide new insight into how cells acquire motility from a stationary epithelial cell type. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4802063 Sun, 08 May 2011 23:00:00 +0100 4802063 http://www.medworm.com/index.php?rid=4794605&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F36 Conclusions: These results suggest that EGFP-fluorescent neurons in laminae I-II coexpress enkephalin and GABA and are involved in the modulation of synaptic transmission of nociceptive information in the spinal dorsal horn. The penk1-EGFP BAC transgenic mouse contributes to the further characterization of the function of enkephalinergic neurons in the transmission and modulation of nociceptive information. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4794605 Fri, 06 May 2011 23:00:00 +0100 4794605 http://www.medworm.com/index.php?rid=4762631&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F35 Conclusions: SNAP25a and SNAP25b display distinct developmental and regional expression profiles in rat and human brain. These differences might reflect distinct functions of these highly conserved isoforms in membrane fusion pathways in the brain. The antibodies generated and characterized in this study represent important tools for future analyses of these essential SNARE protein isoforms. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4762631 Wed, 27 Apr 2011 23:00:00 +0100 4762631 http://www.medworm.com/index.php?rid=4733547&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F33 Conclusions and Limitations: Our analyses showed that genotypes with low 5-HTT activity are associated with less local neural synchronization during relaxation. The implication with respect to genetic vulnerability of 5-HTT across a broad range of psychiatric disorders is discussed. Given the low frequency of 10-repeat allele of 5-HTTVNTR in our research sample, the possibility of false positive findings should also be considered. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4733547 Tue, 19 Apr 2011 23:00:00 +0100 4733547 http://www.medworm.com/index.php?rid=4733546&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F34 Conclusions: p27Kip1 participates in taste cell replacement by regulating the number of precursor cells available for entry into taste buds. This is consistent with a role for the protein in timing cell cycle withdrawal in progenitor cells. The equivalence of mutant and wild-type taste buds with regard to cell number, cell types and general structure contrasts with the hyperplasia and tissue disruption seen in certain developing p27Kip1-null sensory organs, and may reflect a compensatory capability inherent in the regenerative taste system. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4733546 Tue, 19 Apr 2011 23:00:00 +0100 4733546 http://www.medworm.com/index.php?rid=4714533&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F31 Conclusions: Blockade of NMDA by MK801 lends support to the potential importance of NMDA antagonists as therapeutic agents in the treatment of acute spinal cord injury. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4714533 Wed, 13 Apr 2011 23:00:00 +0100 4714533 http://www.medworm.com/index.php?rid=4709032&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F30 Conclusions: Our results demonstrate that the acoustic startle reflex plays a crucial role in mediating flight responses and strongly influences the motivational state of an animal beyond a short-term muscular response by mediating long-term avoidance. The reflex is therefore not only a measure of emotional state but also influences emotional processing. The biological function of the startle reflex is most likely associated with mediating rapid flight responses. The data indicate that repeated startling by anthropogenic noise sources might have severe effects on long-term behaviour. Future, studies are needed to investigate whether such effects can be associated with reduced individual fitness or even longevity of individuals. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4709032 Tue, 12 Apr 2011 23:00:00 +0100 4709032 http://www.medworm.com/index.php?rid=4631338&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F29 Conclusions: The HR mice, i.e. those animals that have a genetic predisposition to hyper-activating their HPA axis in response to stressors, showed disturbed patterns in sleep architecture, similar to what is known from depressed patients. Significant alterations in several frequency bands of the EEG, which also seem to at least partly mimic clinical observations, suggest the SR mouse lines as a promising animal model for basic research of mechanisms underlying sleep impairments in MD. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4631338 Thu, 24 Mar 2011 00:00:00 +0100 4631338 http://www.medworm.com/index.php?rid=4600329&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F28 Conclusions: Consumption of dietary isoflavones or equol exposure in rats has body weight controlling effects and equol specifically may have antidepressant potential dependent upon diet initiation and/or dosage of treatments. The current study demonstrates that equol is able to decrease body weight, abdominal WAT, and depressive-related behavior. While other factors and mechanisms may play a role, in part, the present results provide a greater understanding of how isoflavonoid molecules modulate the brain's influence on behavior. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4600329 Wed, 16 Mar 2011 00:00:00 +0100 4600329 http://www.medworm.com/index.php?rid=4574915&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F27 The perceived size of objects not only depends on their physical size but also on the surroundings in which they appear. For example, an object surrounded by small items looks larger than a physically identical object surrounded by big items (Ebbinghaus illusion), and a physically identical but distant object looks larger than an object that appears closer in space (Ponzo illusion). Activity in human primary visual cortex (V1) reflects the perceived rather than the physical size of objects, indicating an involvement of V1 in illusory size perception. Here we investigate the role of eye-specific signals in two common size illusions in order to provide further information about the mechanisms underlying illusory size perception. We devised stimuli so that an object and its spatial context as... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4574915 Fri, 11 Mar 2011 00:00:00 +0100 4574915 http://www.medworm.com/index.php?rid=4559940&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F24 Conclusions: We conclude that endosomal APP/Rab7 staining reflects impaired vesicle trafficking in WR mouse motor neurons. Based on these findings human ALS tissues were analysed for APP in enlarged vesicles and were detected in spinal cord motor neurons in six out of fourteen sporadic ALS cases. These enlarged vesicles were not detected in any of the familial ALS cases. Thus our study provides the first evidence for wobbler-like aetiologies in human ALS and suggests that the genes encoding proteins involved in vesicle trafficking should be screened for pathogenic mutations. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4559940 Mon, 07 Mar 2011 00:00:00 +0100 4559940 http://www.medworm.com/index.php?rid=4554459&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F23 Conclusions: These results revealed that low-intensity, pulsed FUS sonication suppressed the number of epileptic signal bursts using acute epilepsy model in animal. Due to its non-invasiveness and spatial selectivity, FUS may offer new perspectives for a possible non-invasive treatment of epilepsy. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4554459 Sun, 06 Mar 2011 00:00:00 +0100 4554459 http://www.medworm.com/index.php?rid=4535934&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F22 Conclusions: These data show that compact myelin can be formed with non-hydroxylated sphingomyelin as the predominant sphingolipid and suggest that the presence of HFA-GlcCer and HFA-sphingomyelin in Cgt-/- mice does not functionally compensate the loss of HFA-GalCer. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4535934 Wed, 02 Mar 2011 00:00:00 +0100 4535934 http://www.medworm.com/index.php?rid=4489325&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F20 Conclusions: Kalrn promoter and 3'-terminal exon utilization are region-specific. In the nucleus accumbens, cocaine-mediated alterations in promoter usage and 3'-terminal exon usage favor expression of Kalirin 7 and delta-Kalirin 7. The delta-isoform, which lacks a Sec14p domain and four of the nine spectrin-like repeats found in full-length Kalirin isoforms, increases spine headsize without increasing dendritic spine numbers. Thus cocaine-mediated changes in alternative splicing of the Kalrn gene may contribute importantly to the behavioral, morphological and biochemical responses observed. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4489325 Thu, 17 Feb 2011 00:00:00 +0100 4489325 http://www.medworm.com/index.php?rid=4445536&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F18 Conclusions: These findings show that TSPO expression is up-regulated in cerebral regions of ob/ob leptin-deficient mice, suggesting a role of the translocator protein in leptin-dependent CNS trophism and metabolism. Unchanged SERT in mutant mice is discussed herein in the context of previous literature as the forerunner to a deeper biochemical investigation. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4445536 Mon, 07 Feb 2011 00:00:00 +0100 4445536 http://www.medworm.com/index.php?rid=4405442&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F16 Conclusions: A compartmentalized distribution may have implications for the generation and regulation of local sodium gradients within the spine and for the structural and functional interaction between the sodium pump and other synaptic proteins. Super-resolution microscopy has thus opened up a new perspective to elucidate the nature of the physiological function, regulation and signaling role of Na+,K+-ATPase from its topological distribution in dendritic spines. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4405442 Thu, 27 Jan 2011 00:00:00 +0100 4405442 http://www.medworm.com/index.php?rid=4405443&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F15 Conclusions: Since specific patterns of expression often are linked to equally specialised biological functions, we propose that these cortex sub-region enriched genes are important for proper functioning of the cortical regions in question. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4405443 Wed, 26 Jan 2011 00:00:00 +0100 4405443 http://www.medworm.com/index.php?rid=4399307&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F14 Conclusions: Our findings demonstrate that prior experience which had been accummulated long before the experiments can modulate the time course of perception intriguingly early, namely already immediately after the perceptual onset of a visual event. This modulation cannot solely operate as a feedback in response to the visual event but is rather a permanent effect. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4399307 Wed, 26 Jan 2011 00:00:00 +0100 4399307 http://www.medworm.com/index.php?rid=4394174&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F13 Conclusion: The observation that in schizophrenic patients the PBMC production of selected chemo-cytokines are disregulated reinforces the hypothesis that the peripheral cyto-chemokine network is involved in the pathophysiology of schizophrenia. These preliminary, but promising data are supportive of the application of wider profiling approaches to the identification of biomarker as diagnostic tools for the analysis of psychiatric diseases. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4394174 Tue, 25 Jan 2011 00:00:00 +0100 4394174 http://www.medworm.com/index.php?rid=4382496&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F12 Conclusion: The decreased regenerative capacity that has historically been observed after delayed nerve repair may be related to impaired activation of Schwann cells and increased Schwann cell death. Outgrowing axons influence ERK 1/2 activation and apoptosis of Schwann cells. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4382496 Fri, 21 Jan 2011 00:00:00 +0100 4382496 http://www.medworm.com/index.php?rid=4377362&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F10 Conclusion: We conclude that predominant drinking events evoked by glutamatergic mechanisms, in the presence of prevalently down regulated levels of NR1/2A of some telencephalic and hypothalamic areas appear to constitute an important neuronal switch at least during arousal stage of hibernation. The establishment of the type of glutamatergic subtypes that are linked to successful hibernating states, via drinking stimuli, may have useful bearings toward sleeping disorders. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4377362 Thu, 20 Jan 2011 00:00:00 +0100 4377362 http://www.medworm.com/index.php?rid=4377361&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F11 Conclusion: Activation of macrophage cells in response to the peripheral nerve injury is essential for the enhanced regeneration of ascending sensory neurons. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4377361 Thu, 20 Jan 2011 00:00:00 +0100 4377361 http://www.medworm.com/index.php?rid=4371680&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F8 Conclusion: Major characteristics of the transcriptional profiles in the brains of Bombyx mori at specific development stages were present in this study. Our data provided useful information for future research. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4371680 Wed, 19 Jan 2011 00:00:00 +0100 4371680 http://www.medworm.com/index.php?rid=4371679&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F9 Conclusions: Our results suggest that non-invasive, quantitative bioluminescent imaging using GFAP-luc reporter animal is a useful tool to monitor temporal-spatial kinetics of host-mediated astrogliosis that is associated with brain tumor and metastatic brain tumor growth. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4371679 Wed, 19 Jan 2011 00:00:00 +0100 4371679 http://www.medworm.com/index.php?rid=4342932&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F6 Conclusions: The present parcellation of the Cebus PfC considerably modifies the scheme initially proposed for this species but is in line with previous studies on Old World monkeys. Thus, it was observed that the remarkable anatomical similarity between the brains of genera Macaca and Cebus may extend to architectonic aspects. Since monkeys of both genera evolved independently over a long period of time facing different environmental pressures, the similarities in the architectonic maps of PfC in both genera are issues of interest. However, additional data about the connectivity and function of the Cebus PfC are necessary to evaluate the possibility of potential homologies or parallelisms. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4342932 Thu, 13 Jan 2011 00:00:00 +0100 4342932 http://www.medworm.com/index.php?rid=4342931&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F7 Conclusion: Our data suggests that circadian rhythms can be initiated and maintained in the absence of SCN and other tissues in the ventral brain. However, the SCN may have a role in regulating the amplitude of rhythms when environmental cues are absent. This provides some of the first evidence that the SCN of teleosts is not essential for establishing circadian rhythms during development. Several SCN-independent circadian rhythms have also been found in mammalian species. Thus, zebrafish may serve as a model system for understanding how vertebrate embryos coordinate rhythms that are controlled by different circadian clocks. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4342931 Thu, 13 Jan 2011 00:00:00 +0100 4342931 http://www.medworm.com/index.php?rid=4330804&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F5 Conclusions: B-Raf signaling has a key function in the altered expression of vascular contractile receptors observed after organ culture. Therefore, specific targeting of B-Raf might be a novel approach to reduce tissue damage after cerebral ischemia by preventing the previously observed upregulation of contractile receptors in smooth muscle cells. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4330804 Tue, 11 Jan 2011 00:00:00 +0100 4330804 http://www.medworm.com/index.php?rid=4318133&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F2 Conclusions: The present study demonstrates that tDCS can alter WM performance by modulating the underlying neural oscillations. This result can be considered an important step towards a better understanding of the mechanisms involved in tDCS-induced modulations of WM performance, which is of particular importance, given the proposal to use electrical brain stimulation for the therapeutic treatment of memory deficits in clinical settings. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4318133 Thu, 06 Jan 2011 00:00:00 +0100 4318133 http://www.medworm.com/index.php?rid=4318132&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F3 Conclusions: Our findings indicate that the zebra finch endocannabinoid system is particularly sensitive to exogenous agonist exposure during the critical period of song learning and provide insight into susceptible brain areas. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4318132 Thu, 06 Jan 2011 00:00:00 +0100 4318132 http://www.medworm.com/index.php?rid=4313773&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F12%2F1 Conclusions: Our results indicate that ALPK1 plays an important role in the regulation of motor coordination. Alpk1 PB/PB mice would be a useful model to provide a clue to the better understanding of the cellular and molecular mechanisms of ALPK1 in the control of fine motor activities. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4313773 Wed, 05 Jan 2011 00:00:00 +0100 4313773 http://www.medworm.com/index.php?rid=4302054&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F157 Conclusions: Our findings suggest that the frequency of force modulation has no effect on the beta- and gamma-range CMC during isometric compensation for modulated forces at 8% MVC. The beta- and gamma-range CMC may be related to interindividual differences and possibly to strategy differences. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4302054 Fri, 31 Dec 2010 00:00:00 +0100 4302054 http://www.medworm.com/index.php?rid=4302053&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F158 Conclusions: This first validation demonstrates that our new DCX-CreERT2 transgenic mouse model constitutes a powerful tool to investigate neurogenesis, migration and their long-term fate of neuronal precursors. Moreover, it allows for a targeted activation or deletion of specific genes in neuronal precursors and will thereby contribute to unravel the molecular mechanisms controlling neurogenesis. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4302053 Fri, 31 Dec 2010 00:00:00 +0100 4302053 http://www.medworm.com/index.php?rid=4300471&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F156 Conclusions: Besides the well-known neural habituation mechanisms, bottom-up driven attention plays an important role during auditory processing in noisy environments. This bottom-up driven attention would allow us to track a certain auditory stream under noisy situations without voluntarily paying attention on the auditory signals. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4300471 Thu, 30 Dec 2010 00:00:00 +0100 4300471 http://www.medworm.com/index.php?rid=4337674&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F155 Conclusion: According to our model, experiments in Isl2/EphA3 knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity. Correlated activity can partially restore topographic order even when molecular labels carry conflicting information. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4337674 Wed, 29 Dec 2010 00:00:00 +0100 4337674 http://www.medworm.com/index.php?rid=4298515&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F155 Conclusion: According to our model, experiments in Isl2/EphA3 knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity. Correlated activity can restore topographic order even when molecular labels carry conflicting information. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4298515 Wed, 29 Dec 2010 00:00:00 +0100 4298515 http://www.medworm.com/index.php?rid=4258531&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F154 Conclusions: ATX displayed a unique efficacy with respect to stimulation of sodium influx in cells expressing rNav1.2, rNav1.4 and rNav1.5 alpha-subunits. The efficacy of ATX was distinctive inasmuch as it was not shared by activators of neurotoxin sites 2 and 5 on VGSC alpha-subunits. Given the unique pharmacological properties of ATX interaction with sodium channel alpha-subunits, decoding the molecular determinants and mechanism of action of antillatoxin may provide further insight into sodium channel gating mechanisms. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4258531 Tue, 14 Dec 2010 00:00:00 +0100 4258531 http://www.medworm.com/index.php?rid=4248920&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F153 Conclusions: We conclude that 10% HS is more effective in alleviating cerebral edema than the equal volume of 20% mannitol. This is because 10% HS contributes to establish a higher osmotic gradient across BBB and, furthermore, the progressive accumulation of mannitol in the ischemic brain tissue counteracts its therapeutic efficacy on cerebral edema. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4248920 Fri, 10 Dec 2010 00:00:00 +0100 4248920 http://www.medworm.com/index.php?rid=4213574&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F152 Conclusions: These results suggest that antidepressants function by regulating neurotransmission as well as suppressing immunoreactivity in the central nervous system. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4213574 Tue, 30 Nov 2010 00:00:00 +0100 4213574 http://www.medworm.com/index.php?rid=4213575&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F151 Conclusions: Cultured microglia and astrocytes are differentially affected by PD-CSF exposure compared to non-PD-CSF controls. PD-CSF dramatically impacts microglia cell growth, morphology, and alpha-synuclein deposition compared to astrocytes, supporting the hypothesis of cell specific susceptibility to PD-CSF toxicity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4213575 Mon, 29 Nov 2010 00:00:00 +0100 4213575 http://www.medworm.com/index.php?rid=4203038&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F150 Conclusions: Our study confirms that sensitivity derivatives can be relearned. It is consistent with the idea of a single, all-purpose estimate of those derivatives; and it suggests that the estimate is a function of context, as one would expect given that the true sensitivity derivatives may vary with the state of the controlled system, the target, and the motor commands. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4203038 Fri, 26 Nov 2010 00:00:00 +0100 4203038 http://www.medworm.com/index.php?rid=4200411&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F149 Conclusions: This differential modulation of corticospinal excitability during haptic sensing of 2-D patterns vs. roughness is consistent with the existence of preferred activation of a visuo-haptic cortical dorsal stream network including frontal motor areas during spatial vs. intensive processing of surface properties in the haptic system. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4200411 Thu, 25 Nov 2010 00:00:00 +0100 4200411 http://www.medworm.com/index.php?rid=4196816&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F148 Conclusions: Taken collectively these data indicate a broad overall down-regulation in the genes examined, including genes for neurotrophic/growth factor receptors as well as for several growth factors. There was a lack of a significant regenerative response, with the exception of an up-regulation of Atf3 and early up-regulation of Hspb1 (Hsp27), both involved in cell stress/neuroprotection as well as axonal regeneration. There was no indication of a cell death response over the first month post-injury. In addition, there appear to be significant phenotypic differences between uninjured TPS and LDPT neurons, which may partly account for the differences observed in their post-axotomy responses. The findings in this current study stand in stark contrast to the findings from our previous work... BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4196816 Tue, 23 Nov 2010 00:00:00 +0100 4196816 http://www.medworm.com/index.php?rid=4175467&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F146 Conclusions: Focal cortical infarcts recruit dentate precursor cells generated already before the infarct and significantly contribute to an enhanced neurogenesis. Our findings thereby increase our understanding of the complex cellular mechanisms of postlesional neurogenesis. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4175467 Wed, 17 Nov 2010 00:00:00 +0100 4175467 http://www.medworm.com/index.php?rid=4155033&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F145 Conclusions: Whereas the proximal changes may reflect the off-line effect of direct stimulation of neural elements, the distal changes likely reflect modulation of functional connectivity. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4155033 Wed, 10 Nov 2010 00:00:00 +0100 4155033 http://www.medworm.com/index.php?rid=4151307&cid=s_34037_168_f&fid=34037&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F11%2F144 Conclusion: Rotenone exposure may lead to constitutive protein aggregation in vitro, which may be of relevance to study the mechanisms involved in idiopathic neurodegeneration. (Source: BMC Neuroscience - Latest articles) BMC Neuroscience - Latest articles journals http://www.medworm.com/rss/comments.php?id=4151307 Wed, 10 Nov 2010 00:00:00 +0100 4151307