MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Pharmacology' source. Sat, 20 Mar 2010 14:09:13 +0100 http://www.medworm.com/index.php?rid=3336567&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F10%2F4 Conclusions: A database of benzylisoquinoline compounds has been created, which provides comprehensive information about benzylisoquinoline alkaloids. This database will be very useful for those who are working in the field of drug discovery based on natural products. This database will also serve researchers working in the field of synthetic biology, as developing medicinally important alkaloids using synthetic process are one of important challenges. This database is available from http://crdd.osdd.net/raghava/biadb/. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=3336567 Fri, 05 Mar 2010 00:00:00 +0100 3336567 http://www.medworm.com/index.php?rid=3324066&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F10%2F3 Background: The traditional emphasis on developing high specificity pharmaceuticals ("magic bullets") for the treatment of Neurological and Psychiatric disorders is being challenged by emerging pathophysiology concepts that view disease states as abnormal interactions within complex networks of molecular and cellular components. So-called network pharmacology focuses on modifying the behavior of entire systems rather than individual components, a therapeutic strategy that would ideally employ single pharmacological agents capable of interacting with multiple targets ("magic shotguns"). For this approach to be successful, however, a framework for understanding pharmacological "promiscuity" - the ability of individual agents to modulate multiple molecular targets - is needed.Presentation of ... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=3324066 Tue, 02 Mar 2010 00:00:00 +0100 3324066 http://www.medworm.com/index.php?rid=3241142&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F10%2F2 Conclusions: These results support the concept of both S(-) and R(+) pramipexole enantiomers as mitochondria-targeted antioxidants and suggest that the antioxidant, neuroprotective activity of these drugs is independent of both the chiral 6-propylamino group in the pramipexole molecule and the DA receptor stimulation. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=3241142 Fri, 05 Feb 2010 00:00:00 +0100 3241142 http://www.medworm.com/index.php?rid=3147133&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F10%2F1 CONCLUSION: These results allowed us to establish a relationship between the popular use of Pterodon pubescens seeds for pain relief and the activity of two major compounds isolated from this species which demonstrated antinociceptive activity. Various "in vivo" experimental models corroborate the folk use of this species for different pain and inflammation disorders. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=3147133 Thu, 07 Jan 2010 00:00:00 +0100 3147133 http://www.medworm.com/index.php?rid=3123786&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F15 Conclusions: Our data demonstrate a novel dichotomy in rapacuronium effects at odd-numbered muscarinic receptors. Rapacuronium accelerates the rate of ACh binding but decreases its affinity under equilibrium conditions. This results in potentiation of receptor activation at low concentrations of rapacuronium (1 microM) but not at high concentrations (10 microM). These observations highlight the relevance and necessity of performing physiological tests under non-equilibrium conditions in evaluating the functional effects of allosteric modulators at muscarinic receptors. They also provide molecular basis for potentiating M3 receptor-mediated bronchoconstriction. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=3123786 Mon, 28 Dec 2009 00:00:00 +0100 3123786 http://www.medworm.com/index.php?rid=3045942&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F14 Conclusion: These results indicate that allosteric agonists differ from orthosteric ligands and among each other in their ability to induce different regulatory pathways. Thus, signaling and regulatory pathways induced by different allosteric ligands are ligand specific. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=3045942 Wed, 02 Dec 2009 00:00:00 +0100 3045942 http://www.medworm.com/index.php?rid=3041144&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F13 Conclusion: Spiperone is a calcium regulator. It inhibits Wnt signaling by enhancing intracellular calcium levels. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=3041144 Mon, 30 Nov 2009 00:00:00 +0100 3041144 http://www.medworm.com/index.php?rid=2928578&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F12 Conclusions: An effective BoNT-based drug delivery vehicle can be used to directly deliver toxin inhibitors into intoxicated nerve terminal cytosol. This approach can potentially be utilized for targeted drug delivery to treat other neuronal and neuromuscular disorders. This report also provides new knowledge of endocytosis and exocytosis as well as of BoNT trafficking. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2928578 Tue, 27 Oct 2009 00:00:00 +0100 2928578 http://www.medworm.com/index.php?rid=2798231&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F11 Conclusions: For drugs binding reversibly to DNA, both their strength of binding and their cytoxicity are fairly predicted from molecular descriptors by using multiple regression methods. The equations derived may be useful for rational drug design. The results obtained agree with that compounds more active across the National Cancer Institute's 60-cell line data set tend to have common structural features. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2798231 Tue, 15 Sep 2009 23:00:00 +0100 2798231 http://www.medworm.com/index.php?rid=2798232&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2Fbmcpharmacol%2F Conclusion: Our data show that stimulation of cellular lipid biosynthesis by amphiphilic psychotropic drugs is followed by a transcriptional activation of cholesterol transport and efflux pathways. Such effects may be relevant for both therapeutic effects and metabolic adverse effects of psychotropic drugs. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2798232 Fri, 28 Aug 2009 23:00:00 +0100 2798232 http://www.medworm.com/index.php?rid=2742634&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F10 Conclusion: Our data show that stimulation of cellular lipid biosynthesis by amphiphilic psychotropic drugs is followed by a transcriptional activation of cholesterol transport and efflux pathways. Such effects may be relevant for both therapeutic effects and metabolic adverse effects of psychotropic drugs. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2742634 Fri, 28 Aug 2009 23:00:00 +0100 2742634 http://www.medworm.com/index.php?rid=2429446&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F9 Conclusions: Though it has some RGS selectivity, 5nd appears to be a partially random cysteine modifier. These data suggest that it inhibits RGS4 by forming disulfide bridges with the protein. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2429446 Fri, 22 May 2009 04:00:00 +0100 2429446 http://www.medworm.com/index.php?rid=2333209&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F7 Conclusions: NACA did little to protect NACA H9c2 cells from DOX-induced cell death, even though NACA mitigated the DOX induced decrease of the activities of all of the antioxidant enzymes. These unexpected results suggest that mechanisms not dependent on the production of ROS are involved in DOX induced apoptosis in cardiomyocytes. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2333209 Wed, 15 Apr 2009 04:00:00 +0100 2333209 http://www.medworm.com/index.php?rid=2333208&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F8 Background: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by hamartomatous growths in the brain, skin, kidneys, lungs, and heart, which lead to significant morbidity. TSC is caused by mutations in the TSC1 or TSC2 genes, whose products, hamartin and tuberin, form a tumor suppressor complex that regulates the PI3K/Akt/mTOR pathway. Early clinical trials show that TSC-related kidney tumors (angiomyolipomas) regress when treated with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin (also known as sirolimus). Although side effects are tolerable, responses are incomplete, and tumor regrowth is common when rapamycin is stopped. Strategies for future clinical trials may include the investigation of longer treatment duration and com... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2333208 Wed, 15 Apr 2009 04:00:00 +0100 2333208 http://www.medworm.com/index.php?rid=2307974&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F6 Conclusions: The results in U343 cells suggest that QKI-7 mRNA expression in human astrocytes is induced by Haloperidol, at concentrations similar to plasma levels relevant to clinical treatment of schizophrenia. The molecular mechanism of action of antipsychotic drugs after binding to receptors is not well known. We hypothesize that QKI regulation is involved in this mechanism. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2307974 Tue, 31 Mar 2009 04:00:00 +0100 2307974 http://www.medworm.com/index.php?rid=2269897&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F5 Conclusion: This animal study demonstrated that diclofenac and/or its metabolites were rapidly and preferentially taken up and retained in inflamed tissues. Although there were theoretical considerations that mildly acidic NSAID may show some preferential distribution in inflamed tissues there was no clear experimental proof for diclofenac until the present study. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2269897 Mon, 16 Mar 2009 04:00:00 +0100 2269897 http://www.medworm.com/index.php?rid=2251790&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F4 Background: K+ and Na+ channel toxins constitute a large set of polypeptides, which interact with their ion channel targets. These polypeptides are classified in two different structural groups. Recently a new structural group called birtoxin-like appeared to contain both types of toxins has been described. We hypothesized that peptides of this group may contain two conserved structural motifs in K+ and/or Na+ channels scorpion toxins, allowing these birtoxin-like peptides to be active on K+ and/or Na+ channels. Results: Four multilevel motifs, overrepresented and specific to each group of K+ and/or Na+ ion channel toxins have been identified, using GIBBS and MEME and based on a training dataset of 79 sequences judged as representative of K+ and Na+ toxins. Unexpectedly birtoxin-like pept... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2251790 Tue, 10 Mar 2009 04:00:00 +0100 2251790 http://www.medworm.com/index.php?rid=2237730&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F3 Conclusion: This work raises doubts that lice treated using dimeticone preparations die from anoxia despite blockage of the outer respiratory tract because movements can be observed for hours after exposure. However, the blockage inhibits water excretion, which causes physiological stress that leads to death either through prolonged immobilisation or, in some cases, disruption of internal organs such as the gut. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2237730 Fri, 20 Feb 2009 05:00:00 +0100 2237730 http://www.medworm.com/index.php?rid=2198106&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F3 Conclusions: This work raises doubts that lice treated using dimeticone preparations die from anoxia despite blockage of the outer respiratory tract because movements can be observed for hours after exposure. However, the blockage inhibits water excretion, which causes physiological stress that leads to death either through prolonged immobilisation or, in some cases, disruption of internal organs such as the gut. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2198106 Fri, 20 Feb 2009 05:00:00 +0100 2198106 http://www.medworm.com/index.php?rid=2180473&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F2 Conclusions: AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells. AICAR is therefore a useful pharmacological entity for studying small molecule mediated induction of pluripotency. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2180473 Thu, 12 Feb 2009 05:00:00 +0100 2180473 http://www.medworm.com/index.php?rid=2146444&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F1 Allosteric modulation of membrane receptors is a widespread mechanism by which endogenous and exogenous agents regulate receptor function. For example, several members of the nicotinic receptor family are modulated by physiological concentrations of extracellular calcium ions. In this paper, we examined conformational changes underlying this modulation and compare these with changes evoked by ACh. Two sets of residues in the α7 acetylcholine receptor extracellular domain were mutated to cysteine and analyzed by measuring the rates of modification by the thiol-specific reagent 2-aminoethylmethane thiosulfonate. Using Ba2+ as a surrogate for Ca2+, we found a divalent-dependent decrease the modification rates of cysteine substitutions at M37 and M40, residues at which rates were also slowed ... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2146444 Tue, 13 Jan 2009 05:00:00 +0100 2146444 http://www.medworm.com/index.php?rid=2099739&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F9%2F1 Conclusions: : Our data demonstrate that modulation by divalent cations involves substantial conformational changes in the receptor extracellular domain. Our evidence also suggests the modulation occurs via a binding site distinct from one which includes either (or both) of the conserved glutamates at E44 or E172. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2099739 Tue, 13 Jan 2009 05:00:00 +0100 2099739 http://www.medworm.com/index.php?rid=2031258&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F20 Conclusions: LUF6000 was found to be an allosteric enhancer of Emax of structurally diverse agonists at the A3 AR, being more effective for low-Emax agonists than for high-Emax agonists. LUF6000 was demonstrated to convert an antagonist into an agonist, which represents the first example in G protein-coupled receptors. The observations from the present study are consistent with that predicted by mathematical modeling. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2031258 Fri, 12 Dec 2008 05:00:00 +0100 2031258 http://www.medworm.com/index.php?rid=1950250&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F19 Conclusions: The ability of trans-stilbenes to inhibit or enhance the effects of TPA does not depend upon their anti-oxidant properties. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1950250 Mon, 10 Nov 2008 05:00:00 +0100 1950250 http://www.medworm.com/index.php?rid=1917027&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F18 Background: This phase I study was designed to determine the bioavailability and bioequivalence of 400 mg Eudorlin(R) extra (Ibuprofen) in comparison to two reference formulations (400 mg Nurofen(R) forte and 400 mg Migranin(R)) after single dose administration under fasting conditions in healthy subjects. Therefore the design of a randomized, open label, multiple sequence cross-over study with a wash-out period of 7-10 days was used. Results: AUC0-t(last) and AUC0-infinity (90%CI) were within the 80 to 125 % interval required for bioequivalence as stipulated in the current regulations of the EMEA. Cmax (90%CI) was within the EMEA acceptance range of 75 to 133%. Detailed analyses showed that Cmax of Eudorlin(R) extra was higher than that of Nurofen(R) forte (36.62 vs. 32.92 ug/ml; p=0.0014... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1917027 Wed, 29 Oct 2008 04:00:00 +0100 1917027 http://www.medworm.com/index.php?rid=1846906&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F17 Conclusions: The results suggest that juvenile rats response differently than adult rats to agonist stimulation of alpha-2 adrenoceptors with and without pretreatment with the antidepressant desipramine. In the absence of desipramine pretreatment, the alpha-2 adrenoceptor-induced hypothermic effect in juvenile rats is greater than in adult rats. Acute injections of desipramine, in the absence of agonist produced a hypothermic effect in adult but not juvenile rats. In addition, the increased alpha-2 agonist-induced hypothermic effect following repeated injections of desipramine that is seen in adult rats is not seen in juvenile rats. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1846906 Thu, 02 Oct 2008 04:00:00 +0100 1846906 http://www.medworm.com/index.php?rid=1703762&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F15 Conclusions: These findings demonstrate that, for the group of stilbenes investigated, methoxylation generally increased bioactivity in vivo in a whole organism, with the exception of pinostilbene. Differences in bioactivity in C. elegans adults did not appear to correlate with differential uptake. Rather, we speculate that methoxylated stilbenes may have increased interactions with biological targets in vivo or may interact with specific targets unaffected by hydroxylated stilbenes. The potent activities of methoxylated stilbenes provide a basis for further investigations to identify in vivo targets for these compounds. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1703762 Wed, 13 Aug 2008 04:00:00 +0100 1703762 http://www.medworm.com/index.php?rid=1693275&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F14 Conclusion: The beneficial effects of statins may be attributed to their multiple effects and the study highlights the potential of these drugs in vascular dementia. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1693275 Sat, 09 Aug 2008 04:00:00 +0100 1693275 http://www.medworm.com/index.php?rid=1662862&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F13 Conclusions: Useful classification models can be constructed to predict drug synergism, even in those situations where a limited subset of component drugs can be tested. Compared to the pseudomolecule approach, the virtual docking approach has the advantage of greater potential for biologic interpretation. This distinction may become important as virtual docking software becomes more accurate and docking results more closely resemble actual binding affinities. This is the first published report of a model designed to predict the degree of in-vitro synergism based on the pseudomolecule or docking data approach. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1662862 Tue, 29 Jul 2008 04:00:00 +0100 1662862 http://www.medworm.com/index.php?rid=1515371&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F11 We report that DOV 315,090 possesses modulatory activity at GABAA-Rs, but that its selectivity profile is similar to that of ocinaplon. This implies that DOV 315,090 could contribute to the action of ocinaplon in vivo, but that the anxioselective properties of ocinaplon cannot be readily explained by a subtype selective effect/action of DOV 315,090. Further inquiry is required to identify the extent to which different subtypes are involved in the anxiolytic and other pharmacological effects of GABAA-R modulators. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1515371 Fri, 13 Jun 2008 04:00:00 +0100 1515371 http://www.medworm.com/index.php?rid=1515370&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F12 Conclusions: Multitask learning can be useful in some QSAR models. A suite of QSAR models was constructed and used to screen a large drug library for compounds likely to be cytotoxic to multiple cancer cell lines in vitro, have low systemic toxicity in rats, and have favorable pharmacokinetic properties in humans. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1515370 Fri, 13 Jun 2008 04:00:00 +0100 1515370 http://www.medworm.com/index.php?rid=1511193&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F10 Conclusions: Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. This would explain why beneficial effects of benfotiamine have only been observed in peripheral tissues, while sulbutiamine, a lipid-soluble thiamine disulfide derivative, that increases thiamine derivatives in the brain as well as in cultured cells, acts as a central nervous system drug. We propose that benfotiamine only penetrates the cells after dephosphorylation by intestinal alkaline phosphatases. It then enters the bloodstream as S-benzoylthiamine that is converted to thiamine in erythrocytes and in the liver. Benfotiamine, an S-acyl derivative practically insoluble in organic solvents, should therefore be differentiated from truly ... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1511193 Thu, 12 Jun 2008 04:00:00 +0100 1511193 http://www.medworm.com/index.php?rid=1495824&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F9 Conclusions: In contrast to all three subtypes of the beta-adrenoceptors, but in keeping with the traditional pharmacological dogma, antagonist affinity measurements remained constant at the human H3 receptor, including the medium-efficacy proxyfan-induced state of the receptor and the VUF5681-induced state of the receptor. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1495824 Fri, 06 Jun 2008 04:00:00 +0100 1495824 http://www.medworm.com/index.php?rid=1476625&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F8 Conclusions: We recommend the alamarBlue and CFDA-AM assays for cytotoxicity assessment in ZFL cells, which can be applied either singly or combined. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1476625 Fri, 30 May 2008 04:00:00 +0100 1476625 http://www.medworm.com/index.php?rid=1435564&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F7 Conclusions: RU486 at doses that were efficacious in lowering blood glucose did not exacerbate cytokine release in these three mouse models. RU486 actually suppressed the lower dose LPS-mediated TNFalpha release, possibly due to the increased release of glucocorticoids. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1435564 Mon, 12 May 2008 04:00:00 +0100 1435564 http://www.medworm.com/index.php?rid=1276824&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F5 Conclusions: These findings provide for the first time a global map of the large-scale organization of all known drugs and associated therapies, bringing new insights on possible strategies for future drug development. Special attention should be given to drugs which combine the two properties of (a) having a high centrality value in the drug-therapy network and (b) acting on multiple molecular targets in the human system. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1276824 Tue, 04 Mar 2008 05:00:00 +0100 1276824 http://www.medworm.com/index.php?rid=1276823&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F6 Conclusion: The antidepressant effects antidepressant drugs might be explained by selective modulation of growth factors, which subsequently affects neuronal plasticity. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1276823 Tue, 04 Mar 2008 05:00:00 +0100 1276823 http://www.medworm.com/index.php?rid=1244327&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F4 Conclusions: Thus, the present study highlights that sulphated polysaccharides can act therapeutically against CsA-induced hepatotoxicity. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1244327 Wed, 20 Feb 2008 05:00:00 +0100 1244327 http://www.medworm.com/index.php?rid=1224293&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F3 Conclusion: Inhibition of 11beta HSD1 can be expected to be beneficial for treating the pathology of type 2 diabetes mellitus. The differences seen in adiponectin between BVT116429 and BVT2733 could be explained by different pharmacodynamics exerted by the compounds in different tissues in the body. Increases in adiponectin concentrations may be an integral component in the mechanism of action of this new 11beta HSD1 inhibitor and may be a useful marker of efficacy during the clinical development of 11beta HSD1 inhibitor compounds. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1224293 Tue, 12 Feb 2008 05:00:00 +0100 1224293 http://www.medworm.com/index.php?rid=1221917&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F2 Background: Norfloxacin NOR , as other flour-quinolones, is known to be mutagenic on Salmonella typhimurium TA102 strain. This mutagenic effect is due to free oxygen radicals (ROS), as it is inhibited by antioxidants such as -carotene and natural occurring antioxidants of Roheo discolor and other plants. The aim of this work is to evaluate the combined therapy of norfloxacin and vitamins C and E as an alternative to reduce possible genotoxic risk due to fluoroquinolones treatment. Results: The antimutagenicity of -tocoferol (E) and ascorbic acid (C) was evaluated on the S. typhimurium TA102 employing the aroclor-1254 induced S9 rat liver homogenate, against mutations produced by the fluoro-quinolone norfloxacin NOR . The (minimum inhibitory concentration), MIC , a measurment of bacteric... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1221917 Mon, 11 Feb 2008 05:00:00 +0100 1221917 http://www.medworm.com/index.php?rid=1171799&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F8%2F1 Conclusions: The results of the present study suggest that dicholine salt of succinic acid, a novel neuronal insulin sensitizer, ameliorates cognitive deficits and neuronal dysfunctions in animal models relevant to age-related cognitive impairments, vascular dementia, and Alzheimers disease. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1171799 Wed, 23 Jan 2008 05:00:00 +0100 1171799 http://www.medworm.com/index.php?rid=1109473&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F16 Conclusions: This study further supports the hypothesis that the presence of the beta-AR renders the alpha2A-AR more susceptible to desensitization with physiological levels of EPI. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1109473 Thu, 20 Dec 2007 05:00:00 +0100 1109473 http://www.medworm.com/index.php?rid=1063394&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F15 Conclusion: The formulation of Ce6-PVP is distinctly advantageous as a diagnostic and therapeutic agent for fluorescence diagnosis and PDT of NSCLC. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1063394 Sat, 01 Dec 2007 05:00:00 +0100 1063394 http://www.medworm.com/index.php?rid=1008431&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F14 Conclusions: Preventing the genesis of TSC-related kidney lesions in Tsc2+/- mice is not an effective treatment strategy; rather, the presence of growing tumors appears to be the most important factor when determining an appropriate treatment schedule. Treatment with rapamycin was more effective in reducing tumor growth and improving survival in nude mice bearing Tsc2-/- tumors and also resulted in higher rapamycin levels in blood, brain, and kidney tissue than treatment with an equal milligram dose of CCI-779. We anticipate these results will influence future preclinical and clinical trials for TSC. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=1008431 Tue, 06 Nov 2007 05:00:00 +0100 1008431 http://www.medworm.com/index.php?rid=983551&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F13 Conclusions: Altogether, these results therefore justify further prospective phase I and II clinical trials with combinations of etoposide-based chemotherapy and imatinib in patients with certain cancers, such as malignant lymphoma, with careful toxicologic monitoring. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=983551 Sat, 27 Oct 2007 04:00:00 +0100 983551 http://www.medworm.com/index.php?rid=906797&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F12 Conclusions: Uptake of ciclesonide into A549 cells was more efficient than that of the less lipophilic fluticasone propionate. Intracellular concentrations of the pharmacologically active metabolite des-CIC were maintained for up to 24 h. The local anti-inflammatory activity of ciclesonide in the lung may be prolonged by the slow release of active drug from the depot of fatty acid esters. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=906797 Thu, 27 Sep 2007 04:00:00 +0100 906797 http://www.medworm.com/index.php?rid=885811&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F11 Conclusion: No estrogenic but antiproliferative and proapoptotic gene expression was shown for black cohosh in MCF-7 cells at the transcriptional level. The effects may be results of the activation of different pathways. The cycloartane glycosides and - for the first time - their aglycons could be identified as an active principle in black cohosh. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=885811 Thu, 20 Sep 2007 04:00:00 +0100 885811 http://www.medworm.com/index.php?rid=809210&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F10 Conclusions: An integrative in silico approach for discovering candidates for drug-targetable PPIs was applied to original human PPIs data. The system excludes false positive interactions and selects reliable PPIs as drug targets. Its effectiveness was demonstrated by the discovery of the six promising candidate target PPIs. Inhibition or stabilization of the two interactions may have potential therapeutic effects against human diseases. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=809210 Mon, 20 Aug 2007 04:00:00 +0100 809210 http://www.medworm.com/index.php?rid=698672&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F8 Conclusions: On the basis of our results, we conclude that Ac-DNLD-CHO is a reliable, potent and selective inhibitor of caspase-3. The specific inhibitory effect on caspase-3 suggests that this inhibitor could become an important tool for investigations of the biological function of caspase-3. Furthermore, Ac-DNLD-CHO may be an attractive lead compound to generate novel effective non-peptidic pharmaceuticals for caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=698672 Wed, 27 Jun 2007 04:00:00 +0100 698672 http://www.medworm.com/index.php?rid=665180&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F7 Conclusion: These data suggest that a hypotonic ciclesonide suspension provides higher intracellular concentrations of des-CIC up to 24 h, thereby providing a rationale for investigation of ciclesonide as a convenient once-daily nasal spray for treatment of allergic rhinitis. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=665180 Wed, 06 Jun 2007 04:00:00 +0100 665180 http://www.medworm.com/index.php?rid=475895&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F5 Conclusions: The results show that the metabolite O-desmethyltramadol is more potent in inhibiting peristalsis than its parent compound. The action of all tramadol forms depends on opioid receptors, and that of (+)- and (-)-tramadol also involves adrenoceptors. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=475895 Fri, 16 Mar 2007 04:00:00 +0100 475895 http://www.medworm.com/index.php?rid=461850&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F4 Conclusion: The esterase activities found may condition the pharmacological availability (and depot effect) of orally administered steroid hormone fatty acid esters such as oleoyl-DHEA. The oral administration of oleoyl-DHEA in order to extend DHEA plasma availability has not been proved effective, since the ester is rapidly hydrolysed, probably in the intestine itself, and mainly converted to DHEA-sulfate at least in females. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=461850 Fri, 09 Mar 2007 05:00:00 +0100 461850 http://www.medworm.com/index.php?rid=448195&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F2 Conclusion: Our results provide evidence for a defined role of beta3-containing GABA(A) receptors in mediating some, but not all, of the actions of general anesthetics, and confirming the multisite model of general anesthetic action. This pharmacological separation of anesthetic endpoints also suggests that subtype-selective substances with an improved side-effect profile may be developed. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=448195 Sat, 24 Feb 2007 05:00:00 +0100 448195 http://www.medworm.com/index.php?rid=395620&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F1 Conclusions: Poly-APS induced pore formation in hippocampal neurones and such pores were transient, with neurones recovering from exposure to these polymers. Synthetic structurally related oligomers were not potent pore formers when compared to poly-APS and affected a smaller percentage of the hippocampal neurone population. Poly-APS may have potential as agents for macromolecular delivery into CNS neurones however; the smaller synthetic oligomers tested in this study show little potential for such use. This comparative analysis indicated that the level of polymerisation giving rise to the supermolecular structure in the natural compounds, is likely to be responsible for the activity here reported. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=395620 Fri, 02 Feb 2007 07:00:00 +0100 395620 http://www.medworm.com/index.php?rid=448196&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F7%2F1 Conclusion: Poly-APS induced pore formation in hippocampal neurones and such pores were transient, with neurones recovering from exposure to these polymers. Synthetic structurally related oligomers were not potent pore formers when compared to poly-APS and affected a smaller percentage of the hippocampal neurone population. Poly-APS may have potential as agents for macromolecular delivery into CNS neurones however; the smaller synthetic oligomers tested in this study show little potential for such use. This comparative analysis indicated that the level of polymerisation giving rise to the supermolecular structure in the natural compounds, is likely to be responsible for the activity here reported. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=448196 Fri, 02 Feb 2007 05:00:00 +0100 448196 http://www.medworm.com/index.php?rid=310684&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F14 This is a correction article. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=310684 Wed, 06 Dec 2006 07:00:00 +0100 310684 http://www.medworm.com/index.php?rid=448197&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F14 This is a correction article.After publication of this work 1, we became aware of the fact that Robert C. Speth was not included as an author. Dr. Speth put a considerable amount of time and effort into developing and preparing the radiopeptide used to carry out the radioligand binding studies reported in this manuscript and therefore should have originally been included as an author. We apologize to Dr. Speth for any inconvenience that this oversight might have caused and thank him for his invaluable contribution to this project. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=448197 Wed, 06 Dec 2006 05:00:00 +0100 448197 http://www.medworm.com/index.php?rid=297289&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F13 Conclusions: The results show that PKC inhibitors are able to decrease the ETB receptor contraction and expression in MCA smooth muscle cells following organ culture. The PKC inhibitor 20-28 affects the protein levels, while Ro-32-0432 and bisindolylmaleimide I affect the mRNA levels, suggesting differences in activity profile. Since ETB receptor upregulation is seen in cerebral ischemia, the results of the present study provide a way to interfere with the vascular involvement in cerebral ischemia. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=297289 Tue, 28 Nov 2006 07:00:00 +0100 297289 http://www.medworm.com/index.php?rid=220642&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F12 Background: 6- Shogaol is one of the major compounds in the ginger rhizome that may contribute to its anti-inflammatory properties. Confirmation of this contribution was sought in this study in Sprague- Dawley rats (200-250g) treated with a single injection (0.5ml of 1mg/ml) of a commercial preparation of complete Freunds Adjuvant (CFA) to induce monoarthritis in the right knee over a period of 28 days. During this development of arthritis, each rat received a daily oral dose of either peanut oil (0.2ml-control) or 6-shogaol (6.2mg/Kg in 0.2ml peanut oil). Results: Within 2 days of CFA injection, the control group produced maximum edematous swelling of the knee that was sustained up to the end of the investigation period. But, in the 6-shogaol treated group, significantly lower magnitudes ... BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=220642 Sun, 01 Oct 2006 06:00:00 +0100 220642 http://www.medworm.com/index.php?rid=192474&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F11 Conclusions: In conclusion, two compounds with a novel dopamine/5HT2A receptor profile, LE404 and LE410, with some differences in their respective D1/D2 receptor affinities including a validated pharmacophore-based 3D-QSAR model for D1 antagonists are presented. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=192474 Fri, 15 Sep 2006 06:00:00 +0100 192474 http://www.medworm.com/index.php?rid=62915&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F9 Conclusion: These results are consistent with previous structure-function investigations of the neuropeptide and are the first to propose specific CLR binding contacts for the amidated F37 of CGRP that are important for docking but not activation of the mature CGRP receptor. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=62915 Thu, 15 Jun 2006 06:00:00 +0100 62915 http://www.medworm.com/index.php?rid=2325&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F7 Conclusion: The data demonstrate that AA release is independent of cyclooxygenase activity and together with hemolysis suggest that intercalation of the plasma membrane by some NSAIDs and cancer preventive agents, e.g. tamoxifen, mediates this release. A mechanism by which many of these drugs affect several diverse biologic properties including deesterification of membrane phospholipids by phospholipases to release AA is presented. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2325 Wed, 29 Mar 2006 07:00:00 +0100 2325 http://www.medworm.com/index.php?rid=2326&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F6 Conclusion: The current and previous studies support the following conclusions: 1) cocaine blocks all 3 monoamine transporters at similar concentrations; 2) methylphenidate inhibits DAT and NET well but a 1000-fold higher concentration of the drug is required to inhibit SERT; 3) Amphetamine and methamphetamine are most potent at NET, while being 5- to 9-fold less potent at DAT, and 200- to 500-fold less potent at SERT; 4) MDMA has moderately higher apparent affinity for SERT and NET than for DAT. The relative potencies of a drug to inhibit DAT, NET and SERT suggest which neurotransmitter systems are disrupted the most by each of these stimulants and thus the likely primary mechanism of drug action. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2326 Fri, 03 Mar 2006 07:00:00 +0100 2326 http://www.medworm.com/index.php?rid=2327&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F5 Conclusion: The results suggest that inhibition of p38 MAPK by SB220025 results in increased JNK activity, which leads to stabilisation of iNOS mRNA, to enhanced iNOS expression and to increased NO production. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2327 Tue, 21 Feb 2006 07:00:00 +0100 2327 http://www.medworm.com/index.php?rid=2328&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F4 Conclusion: Insulin at the lowest dose produced an acceleratory effect on SIT that was independent of blood glucose and serum insulin levels in normal mice. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2328 Wed, 01 Feb 2006 07:00:00 +0100 2328 http://www.medworm.com/index.php?rid=2329&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F3 Conclusion: These results elucidate the relative activities of a set of opioid ligands at κ-opioid receptor and can serve as the initial step in a systematic study leading to understanding of the mode of action of these opioid ligands at this receptor. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2329 Wed, 25 Jan 2006 07:00:00 +0100 2329 http://www.medworm.com/index.php?rid=2330&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F2 Conclusion: The data suggest: 1) Androgen depletion or adequate androgen receptor blockade attenuates baroreflex bradycardia. 2) The reflex increase in serum testosterone may counterbalance the action of the lower doses (5 or 15 mg kg-1) of flutamide. 3) The absence of a change in serum 17β-estradiol rules out its contribution to flutamide action on baroreflex bradycardia. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2330 Mon, 23 Jan 2006 07:00:00 +0100 2330 http://www.medworm.com/index.php?rid=2331&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F6%2F1 Conclusion: The ε and θ subunits bring additional features to α3β1 GABAA receptors. These receptor subtypes may constitute as novel drug targets in selected brain regions, e.g., in the brainstem locus coeruleus nuclei. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2331 Fri, 13 Jan 2006 07:00:00 +0100 2331 http://www.medworm.com/index.php?rid=2332&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F5%2F15 Conclusion: In conclusion our study showed that CMN through its antioxidant activity effectively salvaged CsA nephrotoxicity. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2332 Sat, 15 Oct 2005 06:00:00 +0100 2332 http://www.medworm.com/index.php?rid=2333&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F5%2F14 Conclusion: Despite the different experimental conditions used, the only effect on cystometrographic parameters of oxybutynin and tolterodine in anesthetized and conscious rats was a decrease in MP, whereas BVC was hardly and non-significantly affected. Therefore, it is difficult to reproduce in rats the cystometrographic increase in BVC as observed in humans after chronic administration of antimuscarinic agents, whereas the acute effects seem more similar. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2333 Tue, 11 Oct 2005 06:00:00 +0100 2333 http://www.medworm.com/index.php?rid=2334&cid=s_32535_13_f&fid=32535&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2210%2F5%2F13 Conclusion: The presented data demonstrate that the third generation antihistamine, desloratadine, does not significantly antagonize peripheral muscarinic receptors mediating salivation and lacrimation, therefore, xerostomia and dry eyes should not be observed with therapeutic use of desloratadine. Our data also indicate when administered to a patient with a compromised blood-brain barrier, desloratadine may cause sedation. Patients with compromised cardiovascular systems should be closely monitored when administered desloratadine based on our results that desloratadine has the ability to interfere with normal cardiovascular function mediated by muscarinic receptors. (Source: BMC Pharmacology) BMC Pharmacology journals http://www.medworm.com/rss/comments.php?id=2334 Thu, 18 Aug 2005 06:00:00 +0100 2334