MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Basic and Applied Pathology' source. Sun, 21 Mar 2010 15:53:43 +0100 http://www.medworm.com/index.php?rid=3256988&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01070.x Conclusion: The c-kit- or CD133-positive cells appear first at the limiting plate and are then organized into ductular structures or moved to the sinusoid as single cells or clusters during hepatic regeneration. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3256988 Wed, 10 Feb 2010 00:00:00 +0100 3256988 http://www.medworm.com/index.php?rid=3241935&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01061.x We report here the case a 30-year-old parous, phenotypically normal, reproductive woman. She presented with mature teratoma of the ovary, which contained well formed, grossly visible prostatic gland with a central urothelium-lined duct resembling a urethra. Mature teratomas are characterized by the presence of tissues derived from the embryonic layers of ectoderm, mesoderm, or endodermal lineage. However, prostatic tissue is a very unusual component of teratomas. The rare existence of prostatic tissue in a mature teratoma can be explored through three feasible pathogenetic theories. These origins include teratomatous monodermal differentiation, developmental abnormality, or metaplasia. The coexistence of rare prostatic tissue with a rare central urethral duct in a mature teratoma makes thi... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3241935 Fri, 05 Feb 2010 00:00:00 +0100 3241935 http://www.medworm.com/index.php?rid=3241934&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01063.x Conclusions: pSTAT3 and Survivin expression appear to be important prognostic factors for DLBCL patients. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3241934 Fri, 05 Feb 2010 00:00:00 +0100 3241934 http://www.medworm.com/index.php?rid=3241933&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01064.x Conclusions: COX-2 overexpression was significantly associated with favorable clinicopathologic phenotype and an indicator of better survival in our cohort of colorectal cancer patients. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3241933 Fri, 05 Feb 2010 00:00:00 +0100 3241933 http://www.medworm.com/index.php?rid=3241932&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01067.x Early gastric cancer is defined as gastric cancer confined to the mucosa or submucosa. For the majority of early gastric cancers without nodal involvement, endoscopic mucosal removal (EMR) is safer and more cost-effective than are other treatment methods. Here we report a rare case of differentiated mucosal carcinoma with extensive lymphovascular invasion and lymph node metastasis. Endoscopy showed a 5.5 cm non-ulcerated slightly elevated and depressed lesion without indication of submucosal involvement. Although the tumor met the extended criteria for EMR, D2 gastrectomy was performed. The resected specimen showed a 5.5 cm intramucosal carcinoma with extensive lymphovascular invasion of the submucosa, and metastasis to two perigastric nodes, indicating that metastasis can occur in patient... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3241932 Fri, 05 Feb 2010 00:00:00 +0100 3241932 http://www.medworm.com/index.php?rid=3241931&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01068.x Conclusions: CS is a more effective and adequate preparation method for use in EUS-FNA-based diagnosis. Considering the split sample protocol of this study, LBC is a comparable diagnostic tool to CS in the evaluation of EUS-FNA specimens. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3241931 Fri, 05 Feb 2010 00:00:00 +0100 3241931 http://www.medworm.com/index.php?rid=3241930&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01062.x Conclusions: Our data suggest that FNAC is an accurate and reliable first line diagnostic tool for evaluation of breast lesions when compared with core biopsy. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3241930 Fri, 05 Feb 2010 00:00:00 +0100 3241930 http://www.medworm.com/index.php?rid=3241929&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01066.x Primary extracranial meningiomas are rare disease entities, occurring primarily in the head and neck. We herein present a very rare case of primary extracranial meningioma of the retroperitoneum, observed in a 56-year-old man who presented with a retroperitoneal mass measuring 11 cm in its greatest dimension. Histological examination revealed sheets of spindle cells with frequent whorling patterns. The neoplastic cells had abundant light eosinophilic cytoplasm with minimal mitosis or cellular atypism. Immunohistochemical analysis demonstrated diffuse and strong positivity for vimentin and epithelial membrane antigen. Ultrastructural findings revealed abundant intermediate filaments, complex interdigitating cellular processes, and desmosome-like intercellular junctions, all of which are cha... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3241929 Fri, 05 Feb 2010 00:00:00 +0100 3241929 http://www.medworm.com/index.php?rid=3050411&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01065.x (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3050411 Thu, 03 Dec 2009 00:00:00 +0100 3050411 http://www.medworm.com/index.php?rid=3002106&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01056.x Conclusion: The patterns of trkA and trkB mRNA expression were markers for different lineages of transformed cells but were inconsistent with the clinical behavior. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3002106 Wed, 18 Nov 2009 00:00:00 +0100 3002106 http://www.medworm.com/index.php?rid=3002105&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01057.x Gastrinoma is one of the most symptomatic pancreatic endocrine tumors and is associated with recurrent gastric or duodenal ulcer and an induction of chronic gastric acid hypersecretion. This tumor is commonly involved within the gastrinoma triangle. Herein we report a peripancreatic lymph node gastrinoma in a 56-year-old man who was suffered from a recurrent duodenal or jejunal ulcer perforation. Octreotide scan detected a peripancreatic or periduodenal mass and the serum gastrin level was set in upper normal range (107.73 pg/mL). Whipple's procedure was performed. The resected specimen showed multiple duodenal ulcers, hypertrophic gastric body mucosa and an enlarged peripancreatic node, measured 1.5 × 1.0 cm in cross diameter. Microscopic examination revealed a single enlarged lymph node... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3002105 Wed, 18 Nov 2009 00:00:00 +0100 3002105 http://www.medworm.com/index.php?rid=3002104&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01058.x Conclusion: We propose a mean plus a standard deviation as a recommended guideline for staff workload at each laboratory setting to be used for a quality assurance program. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=3002104 Wed, 18 Nov 2009 00:00:00 +0100 3002104 http://www.medworm.com/index.php?rid=2957136&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01053.x Conclusions: PPAR[gamma] expression is related to poor prognostic factors of breast cancer. It is considered that PPAR[gamma] has evident tumor promoting properties in vivo, but receptor-independent effects of PPAR[gamma] ligands may compound its biologic effects in cancer. A better understanding of action mechanisms of the activated PPAR[gamma] is required. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2957136 Wed, 04 Nov 2009 00:00:00 +0100 2957136 http://www.medworm.com/index.php?rid=2957135&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01054.x We report a 62-year-old man who presented with general weakness and poor oral intake for 6 months, and showed multiple masses at the duodenum, jejunum, ileum and the ascending colon. The patient underwent right hemicolectomy with small bowel segmental resection. Microscopically, the tumor masses were characterized by incohesive sheet of neoplastic cells with vesicular nuclei, large nucleoli, and abundant eosinophilic cytoplasm. Immunohistochemical studies showed strong reactivity of the tumor cells for pan-cytokeratin, anti-endomysial antibodies (EMA) and vimentin. This was a case of undifferentiated carcinoma with prominent rhabdoid feautures arising in the ascending colon with multiple gastrointestinal metastases. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2957135 Wed, 04 Nov 2009 00:00:00 +0100 2957135 http://www.medworm.com/index.php?rid=2957134&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01055.x Conclusions: For sinus floor elevation the autogenic bone graft or osteogenic stem cell replacement is necessary, whereas DBM allograft only being insufficient. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2957134 Wed, 04 Nov 2009 00:00:00 +0100 2957134 http://www.medworm.com/index.php?rid=2755343&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01052.x (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2755343 Tue, 01 Sep 2009 23:00:00 +0100 2755343 http://www.medworm.com/index.php?rid=2686691&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01046.x Conclusions:T[beta]RII mutations occur frequently in exon 4 in OSCC and their functional significance should be proven. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2686691 Mon, 10 Aug 2009 23:00:00 +0100 2686691 http://www.medworm.com/index.php?rid=2686690&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01047.x Conclusions: The close correlation between Wip1 overexpression, progesterone receptor expression and nodal metastasis suggest that Wip1 expression is closely associated with HR activity and might heighten the malignant properties of breast cancers through hormone-mediated tumor growth and progression. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2686690 Mon, 10 Aug 2009 23:00:00 +0100 2686690 http://www.medworm.com/index.php?rid=2686689&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01048.x Activated charcoal is commonly used in the treatment of patients experiencing an oral overdose of drugs and is considered to be a safe, inert agent. However, various complications associated with the use of activated charcoal have been reported, with acute respiratory failure being a fatal one. In the presenting case, a 29-year-old female arrived at an emergency room having taken an overdose of drugs. When a nasogastric tube was inserted for gastric lavage and charcoal administration, she vomited and respiration ceased. The patient subsequently developed acute respiratory failure and died 19 days after admission. Charcoal deposition in the trachea, bronchi and lungs was observed on the postmortem examination. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2686689 Mon, 10 Aug 2009 23:00:00 +0100 2686689 http://www.medworm.com/index.php?rid=2686688&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01049.x Conclusions: The results suggest that the survivin expression is a relatively frequent early event of colorectal carcinogenesis and may play an important role in the adenoma-carcinoma transition sequence. Survivin expression provides important prognostic information and an apoptosis-based therapeutic target in colorectal adenocarcinomas. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2686688 Mon, 10 Aug 2009 23:00:00 +0100 2686688 http://www.medworm.com/index.php?rid=2686687&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01050.x Conclusions: This result reconfirmed that the molecular changes associated with CD in Asian populations might differ from Western populations. Furthermore, the genetic change associated with TB in Korea is still remains to be clarified. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2686687 Mon, 10 Aug 2009 23:00:00 +0100 2686687 http://www.medworm.com/index.php?rid=2686686&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01051.x In this report, we summarize the history of the classification system for the reimbursement on pathology services and report the impact of the change in January 2009 on the distribution of cases and contribution on the income of the department of pathology from each class at the Seoul National University Hospital. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2686686 Mon, 10 Aug 2009 23:00:00 +0100 2686686 http://www.medworm.com/index.php?rid=2420163&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01045.x Conclusion: CD56 turns out to be a good negative marker for diagnosing PC. We suggest that immunohistochemical panels directed at the diagnosis of PC should include CD56 together with galectin-3 and CK19. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2420163 Tue, 19 May 2009 04:00:00 +0100 2420163 http://www.medworm.com/index.php?rid=2420166&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01042.x We report a rare case of SH combined with PNEC hyperplasia and tumorlets in a 62-year-old woman. Further studies on the relationship between the histogenesis of SH and PNEC hyperplasia or tumorlets are needed. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2420166 Mon, 18 May 2009 04:00:00 +0100 2420166 http://www.medworm.com/index.php?rid=2420165&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01043.x Conclusion: This is the first report on the existence of p53 codon 249 mutation of HCC in Korea. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2420165 Mon, 18 May 2009 04:00:00 +0100 2420165 http://www.medworm.com/index.php?rid=2420164&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01044.x Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2420164 Mon, 18 May 2009 04:00:00 +0100 2420164 http://www.medworm.com/index.php?rid=2371896&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01041.x Mesonephric rests or mesonephric remnants are vestiges of embryonic structures called mesonephric (wolffian) ducts. It usually can be seen in the lateral wall of the cervix uteri. In males, the mesonephric remnants are seen in epididymis and efferent ductules. Prostate is one of the rare locations, on which the mesonephric remnants can be found. Hyperplasia of mesonephric remnants of prostate is rare but important because sometimes it is difficult to differentiate from adenocarcinoma. The lesion is important in the differential diagnosis from the high grade prostatic intraepithelial neoplasia. Here, we report an additional case of mesonephric hyperplasia, epididymal type, in a 66-year-old man. Microscopically, it showed tubular structures lined by columnar cells with pseudostratified elong... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2371896 Wed, 29 Apr 2009 03:49:01 +0100 2371896 http://www.medworm.com/index.php?rid=2371898&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01039.x The present paper reports a rare case of granulocytic sarcoma (GS) with plasmacytoid features occurring in the maxillary sinus of a 63-year-old man. The diagnosis of GS has always been difficult, and diagnosis in the present case was made more difficult by the tumor's manifestation as longstanding maxillary sinusitis, the late development of leukemia, unusual location of the tumor, and the plasmacytoid features of the tumor cells. The potential for any lesion of any organ to be GS should be considered in a patient with hematologic abnormalities. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2371898 Tue, 28 Apr 2009 04:00:00 +0100 2371898 http://www.medworm.com/index.php?rid=2371897&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01040.x Conclusions: Although parvovirus may not play an important role in Kikuchi's lymphadenitis in Korean patients, PVB19 may be still considered one of the agents, relating with Kikuchi's lymphadenitis in Korea. In contrast to the previous studies, we concluded that the association of PVB19 in Kikuchi's lymphadenitis may be an incidental finding rather than a constant features of this disease. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2371897 Tue, 28 Apr 2009 04:00:00 +0100 2371897 http://www.medworm.com/index.php?rid=2314204&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01035.x A 66-year-old woman died during a routine gastroscopic examination. The physician tried to biopsy a submucosal mass-like lesion with tortuous and exaggerated submucosal blood vessels. Massive bleeding occurred due to iatrogenic injury. Isolated gastric varices are less prevalent than esophageal varices, but it has a higher motality rate because of the difficulty of controlling bleeding. Physicians should be mindful of isolated gastric varices, especially during examination of those with liver cirrhosis. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2314204 Sun, 29 Mar 2009 04:00:00 +0100 2314204 http://www.medworm.com/index.php?rid=2314202&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01038.x Pilomatrixoma is an uncommon benign calcifying epithelial neoplasm derived from hair matrix cells, manifested as a firm intracutaneous spheroid mass on the face, neck, and arms, but its pathogenesis is still not clearly understood. This case study aimed to elucidate the downstream effector molecules and apoptotic processes through the Wnt/[beta]-catenin signaling in an ossifying pilomatrixoma. The histological analysis of whole tissue in this case showed the mixture of shadow and basophilic epithelial cells, where the shadow epithelial cells were most abundant in the superficial layer and the transitional epithelial cells were diffusely distributed between the shadow cells and basophilic cells. The basophilic epithelial cells usually distributed around the basal layer were intensely staine... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2314202 Sun, 29 Mar 2009 04:00:00 +0100 2314202 http://www.medworm.com/index.php?rid=2314200&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01037.x Conclusion: Abnormal preoperative cervical cytology is associated with poor prognostic factors. However, cervical cytology itself neither influences treatment decision nor predicts poor prognosis in endometrial carcinoma. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2314200 Sun, 29 Mar 2009 04:00:00 +0100 2314200 http://www.medworm.com/index.php?rid=2314198&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01034.x Conclusion: Both vitamin E and ginger have protective effect from the cyclophosphamide-induced gonadal toxicity. The mechanism is largely unknown but empirical supplementation of vitamin E and ginger would be recommended before and during cyclophosphamide chemotherapy. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2314198 Sun, 29 Mar 2009 04:00:00 +0100 2314198 http://www.medworm.com/index.php?rid=2270860&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01030.x Conclusions: We demonstrated, for the first time, that Twist is up-regulated in CRA. These results demonstrated that a positive role of Twist in tumor invasion in CRA, and inverse correlation of Twist and E-cadherin expression suggest that Twist may play some role in the EMT by inhibition of E-cadherin activity. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2270860 Tue, 17 Mar 2009 04:00:00 +0100 2270860 http://www.medworm.com/index.php?rid=2270859&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01031.x Conclusions: Taken together, our results support the idea that expression of COX-2 plays a crucial role during malignant transformation being closely related to neoplastic conversion of the oral mucosa cells. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2270859 Tue, 17 Mar 2009 04:00:00 +0100 2270859 http://www.medworm.com/index.php?rid=2270858&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.01032.x We report a case of primary non-Hodgkin's lymphoma (NHL) of the uterine body with involvement of bilateral ovaries. A 67-year-old woman had explolaparotomy under the provisional diagnosis of uterine leiomyoma. Enlargements of the uterine body as a leiomyoma and bilateral ovaries were noted in the operation field. The frozen section diagnosis of the uterine wall mass was malignant lymphoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was carried out. The pathologic study with immunohistochemical stains confirmed primary NHL of the diffuse large B-cell type of the myometrium with involvement of bilateral ovaries. To the best of our knowledge, the primary lymphoma of the myometrium with involvement of bilateral ovaries has not been reported previously in the literature. ... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2270858 Tue, 17 Mar 2009 04:00:00 +0100 2270858 http://www.medworm.com/index.php?rid=2178298&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.00044.x (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178298 Tue, 10 Feb 2009 05:00:00 +0100 2178298 http://www.medworm.com/index.php?rid=2178297&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00037.x We report these cases with a discussion of the use of anti-obesity drugs. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178297 Tue, 10 Feb 2009 05:00:00 +0100 2178297 http://www.medworm.com/index.php?rid=2178296&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2009.00043.x Conclusions: Increased BPs in the lung might be related to the fibrogenic process of interstitial lung diseases. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178296 Tue, 10 Feb 2009 05:00:00 +0100 2178296 http://www.medworm.com/index.php?rid=2178295&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00041.x Conclusions: CXCR4 expression is a significant prognostic factor in non-small cell carcinoma, especially squmous cell carcinoma. Well designed, larger studies on CXCR4 and EGFR expressions will be needed to confirm their significances. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178295 Tue, 10 Feb 2009 05:00:00 +0100 2178295 http://www.medworm.com/index.php?rid=2178294&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00040.x Conclusions: The relatively high rate of HER2 amplification among IHC 1+ or 2+ cases at our institute emphasizes the importance of validating HER2 testing in different laboratories and the need for complementary HER2 FISH in IHC 1+ patients. Most patients equivocal for HER2 amplification had HER2 high polysomy and expressed hormone receptor. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178294 Tue, 10 Feb 2009 05:00:00 +0100 2178294 http://www.medworm.com/index.php?rid=2178293&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.01033.x Conclusions: GPC3 and MAGE-1 are useful biomarkers indicating tumor aggressiveness as well as potent target proteins for HCC immunotherapy. AFP staining had a high false positivity and further evaluation is required. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178293 Tue, 10 Feb 2009 05:00:00 +0100 2178293 http://www.medworm.com/index.php?rid=2178292&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00038.x Conclusions: CD44 may be partly involved in the progression of colorectal adenocarcinoma. The role of OPN and NF[kappa]B may be minor in the carcinogenesis and tumor progression. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178292 Tue, 10 Feb 2009 05:00:00 +0100 2178292 http://www.medworm.com/index.php?rid=2178291&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00039.x Conclusions: We successfully investigated the lungs of the mummy by using bronchoscopy, MDCT and microscopic analysis. The pollen grains found in the bronchi of the mummy, which was previously used as an hemostatics in ancient oriental medicine, could guide us in determining more about General Hak-Bong's death. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=2178291 Tue, 10 Feb 2009 05:00:00 +0100 2178291 http://www.medworm.com/index.php?rid=1992631&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00033.x Sudden unexpected deaths due to cardiovascular diseases make up almost half of all natural deaths. Practical guidelines are needed for forensic autopsy practice in cases of natural unexpected deaths due to ischemic heart disease or other cardiovascular diseases in Korea. An evaluation of the clinical history is the first step, including the collection of all available information on the subject. As a standard autopsy procedure, every subsystem of the heart and vessels should be thoroughly studied including the coronary arteries, the myocardium, the cardiac valves, and the conducting system. In addition, histological, toxicological, biochemical and molecular analysis need to be applied to the detection of myocardial infarction from the medico-legal point of view. Also important is the asses... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1992631 Thu, 27 Nov 2008 05:00:00 +0100 1992631 http://www.medworm.com/index.php?rid=1934797&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00026.x We report a case of metastatic MTC presented as palpable neck and breast nodules in a 39-year-old woman. Fine needle aspiration of breast nodules showed a cellular smear with relatively homogenous, poorly cohesive tumor cells in a relatively clean background. The tumor cells were round to oval, with hyperchromatic nuclei, abundant cytoplasm and plasmacytoid in appearance. A few amorphous materials, possibly amyloid, were also noted. The patient underwent radical thyroidectomy, cervical lymph node dissection and excision of breast nodules. The primary thyroid mass was typical of MTC but metastatic breast tumors showed more homogenous and smaller tumor cells. The cellular origin of the breast tumors was confirmed by their immunoreactivity for calcitonin, chromogranin, synaptophysin and TTF-1... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1934797 Wed, 05 Nov 2008 05:00:00 +0100 1934797 http://www.medworm.com/index.php?rid=1934801&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00035.x Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1934801 Tue, 04 Nov 2008 05:00:00 +0100 1934801 http://www.medworm.com/index.php?rid=1934800&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00029.x Conclusions: These results suggest an elevation of HO-1 expression in OLP. HO-1 may play an adaptive or cytoprotective role during the immunologic stress of OLP. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1934800 Tue, 04 Nov 2008 05:00:00 +0100 1934800 http://www.medworm.com/index.php?rid=1934799&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00031.x Gastrointestinal stromal tumors (GISTs) present as a spectrum, from clinically benign to malignant. Metastases usually become clinically apparent within 18[ndash]24 months of diagnosis, though they can develop as many as 30 years after primary tumor removal. The most common metastatic sites are the peritoneal surface and the liver. Pulmonary metastases are less common (approximately 7% of all metastises). Here, we report a case of pulmonary metastasis of a GIST of the rectum. A 50 year-old-woman, having received a Miles' operation for GIST of the rectum 10 years previous, was found to have a tumor in the right lung during a follow-up examination. A 2.5 cm sized well-demarcated mass presented in her lung parenchyma. The tumor was composed of spindle and epithelioid cells showing diffuse and... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1934799 Tue, 04 Nov 2008 05:00:00 +0100 1934799 http://www.medworm.com/index.php?rid=1934798&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00032.x There is a controversy on the causal relationship of sexual intercourse as a cause of sudden death. Since sildenafil (Viagra[trade]) has been introduced in 1998, there are more concerns on the safety issue of sildenafil and sexual activity as a forensic determination of the cause of death in those cases. We have collected 68 cases of sudden death occurred within 24 hours after sexual intercourse among 13,824 cases for five years from 2001 at the head office of the National Institute of Scientific Investigation in Seoul, Korea. There were 59 men and 9 women (M:F = 6.6:1). The most common cause of death was ischemic heart disease (20 in 68, 29.4%) in both men and women. Sildenafil (Viagra[trade]) was detected in blood in 8 men and only in gastric content in 2 men (10/59, 17.0%). The level in... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1934798 Tue, 04 Nov 2008 05:00:00 +0100 1934798 http://www.medworm.com/index.php?rid=1918528&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00028.x (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1918528 Thu, 30 Oct 2008 04:00:00 +0100 1918528 http://www.medworm.com/index.php?rid=1918529&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00027.x Conclusions: Combined chromosome 16 and 7 numerical imbalances and not e-cadherin/EGFR protein alterations maybe influence the prognosis for CRC patients. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1918529 Wed, 29 Oct 2008 04:00:00 +0100 1918529 http://www.medworm.com/index.php?rid=1902899&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00025.x Conclusions: Considering that Bcl-2 has an anti-apoptotic effect, our findings suggest that pro-apoptotic stimuli may be predominant in breast carcinomas with a basal-like phenotype. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1902899 Fri, 24 Oct 2008 04:00:00 +0100 1902899 http://www.medworm.com/index.php?rid=1609452&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00023.x Florid cemento-osseous dysplasia (FCOD) is a benign, non-neoplastic lesion characterized by multiple sclerosing masses only within jawbones. It is frequently confused with chronic diffuse sclerosing osteomyelitis (CDSO) in the literature. Two cases of FCOD are examined to determine the characteristics of their calcifying tissues. The first case was non-infected, while the second case was severely infected, displaying the typical features of CDSO in clinico-radiologic findings. The infected FCOD case showed large bacterial colonies in the main lesion with rare inflammatory reaction. The globular cementum-like materials of FCOD looked like woven bone and showed increased positive reaction to Alcian blue stain, of which peripheral margin was strongly positive for the antibody of ameloblastin,... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609452 Sat, 28 Jun 2008 04:00:00 +0100 1609452 http://www.medworm.com/index.php?rid=1609451&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00022.x We report a case of malignant solitary fibrous tumor in the back of a 27-year-old male patient. Grossly, the mass was well circumscribed, unencapsulated, soft to rubbery, oval shaped and measured 11.0 cm at its greatest diameter. The cut surface showed multinodular whitish-gray to tan solid appearance. Microscopically, the tumor revealed a wide spectrum of histologic features with alternating hypercellular and hypocellular areas, patternless architecture, haphazard arrangement of oval to spindle cells, branching vessels with perivascular hyalinization, frequent keloid-like collagen deposits and stromal hyalinization. Multifocal hypercellular areas revealed moderate to marked cytologic atypia and frequent mitotic figures with atypical mitoses. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609451 Sat, 28 Jun 2008 04:00:00 +0100 1609451 http://www.medworm.com/index.php?rid=1609450&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00024.x We describe the immunohistochemical findings of the skin lesion of Kikuchi's disease (KD) in two patients. They presented with fever, lymphadenopathy, and eruptions on the skin of palm and face. Each patient had a lymph node biopsy which showed the typical necrotizing lymphadenitis of KD. Skin biopsies from the two patients showed various pathologic findings of a crusted epidermis, a dense lymphohistiocytic perivascular and interstitial infiltrate, and abundant karyorrhectic debris with an absence of neutrophils, paralleling the nodal histology in KD. Immunohistochemically, the lymphohistiocytic cells in the skin and lymph nodes showed similar positivity for CD68, CD3, CD8, granzyme B and negativity for CD20 and CD4. These findings suggest that the cytotoxic T lymphocytes play important ro... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609450 Sat, 28 Jun 2008 04:00:00 +0100 1609450 http://www.medworm.com/index.php?rid=1609449&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00020.x Conclusions: Notch receptors play an inhibitory role in metastasis to lymph node and in the activity of cell cycle proteins, which may lead to suppression of NSCLC. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609449 Sat, 28 Jun 2008 04:00:00 +0100 1609449 http://www.medworm.com/index.php?rid=1609448&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00019.x Conclusions: A good correlation was observed between cervical lesion grade and p16 expression, decreased cyclin D1 expression, and HR-HPV status. p16 expression could be used as a diagnostic and prognostic biomarker for risk of developing cervical cancer in women infected with HPV. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609448 Sat, 28 Jun 2008 04:00:00 +0100 1609448 http://www.medworm.com/index.php?rid=1609447&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00018.x Conclusions: The reported Korean cases of thymic MALT lymphoma might have different autoimmune context although our series reconfirms other distinctive clinicopathologic and molecular characteristics of thymic MALT lymphomas. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609447 Sat, 28 Jun 2008 04:00:00 +0100 1609447 http://www.medworm.com/index.php?rid=1609446&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00017.x Conclusions: Multiple localizations of NDRG2 protein suggest pleiotropic functions through interaction with other proteins. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609446 Sat, 28 Jun 2008 04:00:00 +0100 1609446 http://www.medworm.com/index.php?rid=1609445&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00016.x Conclusions: Methacarn is an excellent fixative for human tissue samples obtained by microdissection. It is an optimal fixative that is not only excellent for preservation of morphology, but also RNA extraction. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609445 Sat, 28 Jun 2008 04:00:00 +0100 1609445 http://www.medworm.com/index.php?rid=1609444&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00015.x Conclusion: The CISH method is useful in detecting chromosomal change in RCC, and the identification of chromosome 17 monosomy is helpful in diagnosis of chRCC. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609444 Sat, 28 Jun 2008 04:00:00 +0100 1609444 http://www.medworm.com/index.php?rid=1609443&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00014.x Conclusions: These results suggest that CDX2 may play an important role in gallbladder carcinogenesis with intestinal differentiation. (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609443 Sat, 28 Jun 2008 04:00:00 +0100 1609443 http://www.medworm.com/index.php?rid=1609442&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00013.x Liver fibrosis is the common scarring response of the liver to most chronic liver damage. Continuous chronic liver damage leads to a progressive accumulation of scarring proteins and finally, alters normal tissue structure and function by inducing fibrosis, cirrhosis and ultimately liver failure. Despite the considerable evolution on the study of liver fibrosis and cirrhosis during the past decade, a full understanding of liver fibrosis and cirrhosis still remains a goal for scientists. Although liver fibrosis and cirrhosis is mediated by various cytokines including tumor necrosis factor-alpha, interleukin-10 and transforming growth factor-beta (TGF-[beta]), it has been shown that TGF-[beta] plays the most significant role in chronic liver disease. In early liver injury stage, TGF-[beta] i... Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609442 Sat, 28 Jun 2008 04:00:00 +0100 1609442 http://www.medworm.com/index.php?rid=1609441&cid=s_37713_32_f&fid=37713&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1755-9294.2008.00021.x (Source: Basic and Applied Pathology) Basic and Applied Pathology journals http://www.medworm.com/rss/comments.php?id=1609441 Sun, 01 Jun 2008 04:00:00 +0100 1609441