MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BioMed Central' source. Wed, 08 Feb 2012 18:50:18 +0100 http://www.medworm.com/index.php?rid=5668392&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2458%2F12%2F108 Conclusions: Statistically significant high-risk spatial clusters of suicide were detected at the county level. This study may be useful for guiding future research and intervention efforts. Future studies will need to focus on these high-risk clusters to investigate reasons for these occurrences. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668392 Wed, 08 Feb 2012 05:00:00 +0100 5668392 http://www.medworm.com/index.php?rid=5668391&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2172%2F13%2F7 Conclusions: Our results suggest that differential expression of NKG2D-ligands in cervical cancer cell lines might be associated with the down-modulation of NKG2D, as well as with changes in the cytotoxic activity of NKL cells after cell-cell contact with the tumor cells. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668391 Wed, 08 Feb 2012 05:00:00 +0100 5668391 http://www.medworm.com/index.php?rid=5668390&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jbiomedsci.com%2Fcontent%2F19%2F1%2F19 Conclusion: These data support that C. neoformans internalization into HBMEC is a lipid raft/caveolae-dependent endocytic process where the actin cytoskeleton is involved, and the Cav1 plays an essential role in C. neoformans traversal of the blood-brain barrier. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668390 Wed, 08 Feb 2012 05:00:00 +0100 5668390 http://www.medworm.com/index.php?rid=5668389&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.veterinaryresearch.org%2Fcontent%2F43%2F1%2F10 Leishmania is inoculated, by the bite of an infected sandfly, into the skin of the host, where the promastigotes are phagocyted by dermal macrophages. The dermal region comprises cells and abundant extracellular matrix. Studies show that matrix metalloproteinases play an important role in host defense responses against pathogens in mammals and that their activities lead to the production of antimicrobial peptides. The aim of this study is to evaluate the changes in the distribution of fibronectin and laminin as well as in the elastic system fibres during the course of infection caused by Leishmania amazonensis in mice with distinct genetic backgrounds of susceptibility to this parasite. The results showed that BALB/c presented an enhancement of fibronectin during the course of infection wh... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668389 Wed, 08 Feb 2012 05:00:00 +0100 5668389 http://www.medworm.com/index.php?rid=5668388&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F16%2F1%2F402 Following publication of our article [1], Dr Christine Geffers has been removed as co-author. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668388 Wed, 08 Feb 2012 05:00:00 +0100 5668388 http://www.medworm.com/index.php?rid=5668387&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F16%2F1%2F303 Hospital handoffs are believed to be a key locus of communication breakdown that can endanger patient safety and undermine quality of care. Substantial new efforts to better understand handoffs and to improve handoff practices are under way. Many such efforts appear to be seriously hampered, however, by an underlying presumption that the essential function of a handoff is one-way information transmission. Here, we examine social science literature that supports a richer framing of handoff conversations, one that characterizes them as co-constructions of an understanding of the patient. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668387 Wed, 08 Feb 2012 05:00:00 +0100 5668387 http://www.medworm.com/index.php?rid=5668386&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F16%2F1%2F204 Over the past decade several investigators have applied microarray technology and related bioinformatic approaches to clinical sepsis and septic shock, thus allowing for an assessment of how, or if, this branch of genomic medicine has meaningfully impacted the field of sepsis research. The ability to simultaneously and efficiently measure the steady-state mRNA abundance of thousands of transcripts from a given tissue source (that is, 'transcriptomics') has provided an unprecedented opportunity to gain a broader, genome-level 'picture' of complex and heterogeneous clinical syndromes such as sepsis. A trancriptomic approach to sepsis and septic shock is technically challenging on multiple levels, but nonetheless modest, tangible advances are being realized. These include a genome-level under... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668386 Wed, 08 Feb 2012 05:00:00 +0100 5668386 http://www.medworm.com/index.php?rid=5668385&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F16%2F1%2F410 no abstract available. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5668385 Wed, 08 Feb 2012 05:00:00 +0100 5668385 http://www.medworm.com/index.php?rid=5660723&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.molecular-cancer.com%2Fcontent%2F11%2F1%2F6 Conclusions: PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660723 Sun, 05 Feb 2012 05:00:00 +0100 5660723 http://www.medworm.com/index.php?rid=5660730&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F13%2F59 Conclusions: Our results show that epigenetic variation is inherited in chickens, and we suggest that selection of favourable epigenomes, either by selection of genotypes affecting epigenetic states, or by selection of methylation states which are inherited independently of sequence differences, may have been an important aspect of chicken domestication. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660730 Sat, 04 Feb 2012 05:00:00 +0100 5660730 http://www.medworm.com/index.php?rid=5660729&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.proteomesci.com%2Fcontent%2F10%2F1%2F7 Naturally occurring native peptides provide important information about physiological states of an organism and its changes in disease conditions but protocols and methods for assessing their abundance are not well-developed. In this paper, we describe a simple procedure for the quantification of non-tryptic peptides in body fluids. The workflow includes an enrichment step followed by two-dimensional fractionation of native peptides and MS/MS data management facilitating the design and validation of LC- MRM MS assays. The added value of the workflow is demonstrated in the development of a triplex LC-MRM MS assay used for quantification of peptides potentially associated with the progression of liver disease to hepatocellular carcinoma. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660729 Sat, 04 Feb 2012 05:00:00 +0100 5660729 http://www.medworm.com/index.php?rid=5660728&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.actavetscand.com%2Fcontent%2F54%2F1%2F9 Conclusions: The results from this study show that infection of calves with M. bovis results in various lung lesions including caseonecrotic pneumonia originating from bronchioli and bronchi. There is long-term persistence of M. bovis as demonstrated by bacteriology and immunohistochemistry for M. bovis antigens, i.e. Vsp antigens and pMB67. The persistence of the pathogen and its ability to evade the specific immune response may in part result from local downregulation of antigen presenting mechanisms and an ineffective humoral immune response with prevalence of IgG1 antibodies that, compared to IgG2 antibodies, are poor opsonins. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660728 Sat, 04 Feb 2012 05:00:00 +0100 5660728 http://www.medworm.com/index.php?rid=5660727&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2431%2F12%2F12 Conclusions: The nutrient intake and excessive EDNP food consumption levels of Australian rural children from disadvantaged areas are cause for concern regarding their future health and wellbeing, particularly for Indigenous boys. Targeted intervention strategies should address the high consumption of these foods. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660727 Sat, 04 Feb 2012 05:00:00 +0100 5660727 http://www.medworm.com/index.php?rid=5660726&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2091%2F13%2F4 Conclusions: We provide direct evidence that avian preen glands possess both monofunctional and bifunctional WS proteins which have different expression patterns and WS activities with different substrate specificities. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660726 Sat, 04 Feb 2012 05:00:00 +0100 5660726 http://www.medworm.com/index.php?rid=5660725&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F16%2F1%2FR21 Power injectable peripherally inserted central catheters can be used successfully in most intensive care unit patients with few contraindications and low rates of complications, similar to central venous catheters (CVC). (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660725 Sat, 04 Feb 2012 05:00:00 +0100 5660725 http://www.medworm.com/index.php?rid=5660724&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jbiomedsci.com%2Fcontent%2F19%2F1%2F15 Conclusion: Our data suggested p65 could increase p53-mediated cell death in response to DOX in PANC1 cells. Thus, it is worth noting that in p53 null or defective tumors, targeting in down-regulation of p65 may well be useful, leading to the potentiality of chemotherapeutic drugs. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5660724 Sat, 04 Feb 2012 05:00:00 +0100 5660724 http://www.medworm.com/index.php?rid=5649644&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2121%2F13%2F3 Conclusion: These results show that in P. misakiensis, the cytostatic activity of TC14-3 is mediated by PmEed and resultant histone modification, and that the gene expression requires both the protein dimerization and Ca2+-binding of TC14-3. This system consisting of a humoral factor, PcG, and histone methylation would contribute to the homeostatic regulation of cell growth and terminal differentiation of invertebrate multipotent cells. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5649644 Thu, 02 Feb 2012 05:00:00 +0100 5649644 http://www.medworm.com/index.php?rid=5649643&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.molecularneurodegeneration.com%2Fcontent%2F7%2F1%2F4 Conclusion: Taken together, our findings suggest that Top IIbeta might be a down-stream target of Nurr1, which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression. The Nurr1-Top IIbeta interaction may shed light on the pathologic role of Nurr1 defect in the nigro-striatal pathway deficiency associated with PD. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5649643 Thu, 02 Feb 2012 05:00:00 +0100 5649643 http://www.medworm.com/index.php?rid=5649642&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.parasitesandvectors.com%2Fcontent%2F5%2F1%2F25 This study was designed to validate RAPLOA in two regions in the North East and South West of the Democratic Republic of Congo. In each selected community, 80 people above the age of 15 years were interviewed for a history of eye and parasitologically examined for the presence and intensity of L. loa infection. The results confirmed the findings of the original RAPLOA study and the methodology is recommended for the assessment of loiasis endemicity in areas targeted for ivermectin treatment by lymphatic filariasis and onchocerciasis control programmes. Image: RAPLOA Interview; Field surveyor showing the picture of L. loa in the Eye to a participant (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5649642 Thu, 02 Feb 2012 05:00:00 +0100 5649642 http://www.medworm.com/index.php?rid=5649641&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.molecularbrain.com%2Fcontent%2F5%2F1%2F5 Conclusion: These results indicate that the quality of place memories is not determined by brain regions on which the memory depends. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5649641 Thu, 02 Feb 2012 05:00:00 +0100 5649641 http://www.medworm.com/index.php?rid=5649640&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.particleandfibretoxicology.com%2Fcontent%2F9%2F1%2F3 Conclusions: A particle size reduction in silica particles enhanced IL-18 and TSLP production, which leads to systemic Th2 response and aggravation of AD-like skin lesions as induced by Dp antigen treatment. We believe that appropriate regulation of nanoparticle physicochemical properties, including sizes, is a critical determinant for the design of safer forms of NMs. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5649640 Thu, 02 Feb 2012 05:00:00 +0100 5649640 http://www.medworm.com/index.php?rid=5649639&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.equityhealthj.com%2Fcontent%2F11%2F1%2F6 Conclusions: Neither reform seems to have had a decisive positive impact on the health outcomes analyzed for the defined time period of this research. This, in turn, may be a consequence of both internal characteristics of the respective reforms and external factors beyond the direct control of health reformers. Among the internal characteristics: underfunding, unbridled decentralization and inequitable access to care seem to have been the main constraints. Conversely, international economic adversities, high levels of rural and urban violence, along with entrenched income inequalities seem to have accounted for the highest burden among external factors. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5649639 Thu, 02 Feb 2012 05:00:00 +0100 5649639 http://www.medworm.com/index.php?rid=5639296&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.molecularcytogenetics.org%2Fcontent%2F5%2F1%2F9 Conclusion: This is the first investigation of a panel of CMMS in a large sample set of "familial ID patients". The findings of this study showed the low prevalence of CMMSs in "familial ID" patients in spite of the significant contribution of such aberrations in "sporadic ID" which has a very useful practical impact by avoiding unnecessary diagnostic tests in "familial ID" patients. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5639296 Sun, 29 Jan 2012 05:00:00 +0100 5639296 http://www.medworm.com/index.php?rid=5639295&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.hqlo.com%2Fcontent%2F10%2F1%2F12 Background: Quality of life (QOL) is an important measure in the management of Irritable Bowel Syndrome (IBS). Controversy exists in the findings of studies evaluating QOL in IBS subtypes, and little is known about this issue in Iranian patients. Determination of the factors affecting QOL in IBS patients may influence treatment outcomes. The aims of this study are to: 1) compare QOL between subtypes in a sample of Iranian IBS patients, 2) determine the factors associated with QOL in IBS. Methods: This cross sectional study included two hundred and fifty IBS patients with the mean age (+/- standard deviation) of 31.62 (+/- 11.93) years that were referred to outpatient gastroenterology clinic. IBS patients were diagnosed based on Rome-3 criteria by a gastroenterologist, and then they were ca... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5639295 Sun, 29 Jan 2012 05:00:00 +0100 5639295 http://www.medworm.com/index.php?rid=5639294&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.sjtrem.com%2Fcontent%2F20%2F1%2F6 Conclusion: In cardiac arrest patients treated with hypothermia, prognostication of unfavourable outcome by NSE kinetics between admission and 48 hours after resuscitation may be superior to prognostication by absolute NSE levels. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5639294 Sun, 29 Jan 2012 05:00:00 +0100 5639294 http://www.medworm.com/index.php?rid=5639293&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F79 Conclusion: In practice, CLC performs better in assembling highly heterogeneous genome sequences compared to CAP3, and consequently SNP retrieval is more efficient. Additionally a simple flow scheme is suggested for SNP marker retrieval that can be valid for all non-model species. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5639293 Sun, 29 Jan 2012 05:00:00 +0100 5639293 http://www.medworm.com/index.php?rid=5639298&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.ethnobiomed.com%2Fcontent%2F8%2F1%2F6 Background: Ethnobotanical studies are crucial in South-Eastern Europe for fostering local development and also for investigating the dynamics of Traditional Environmental Knowledge (TEK) related to plants in one of the most crucial European hotspots for biocultural diversity. The current medico-ethnobotanical survey was conducted in rural alpine communities in Kosovo. The aims of the study were twofold: 1) to document the state of TEK of medicinal plants in these communities; 2) to compare these findings with that of similar field studies previously conducted among local populations inhabiting the Montenegrin and Albanian side of the same Alpine range. Methods: Field research was conducted in 36 villages on the Kosovar side of the Albanian Alps. Snowball sampling techniques were used to r... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5639298 Sat, 28 Jan 2012 05:00:00 +0100 5639298 http://www.medworm.com/index.php?rid=5639297&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.health-policy-systems.com%2Fcontent%2F10%2F1%2F3 Conclusion: The evolution of tobacco control research in Thailand provides examples of steppingstones that LMICs may be able to use to construct their own tobacco control research pathways.Key words: tobacco control, smoking, policy, research, capacity building, secondhand smoke, Thailand, Asia (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5639297 Sat, 28 Jan 2012 05:00:00 +0100 5639297 http://www.medworm.com/index.php?rid=5630254&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F46 Conclusions: Over the last years, endoscopic procedures increased markedly in The Netherlands without a corresponding increase in manpower. A FIT-based CRC screening program requires an additional 15% increase in endoscopic procedures. It is very likely, that current colonoscopy density varies widely across European countries.Word count: 244 including headers (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630254 Thu, 26 Jan 2012 05:00:00 +0100 5630254 http://www.medworm.com/index.php?rid=5630253&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F73 Conclusions: These data reveal insight into genes and molecular pathways mediating ESCC development and provide information potentially useful in designing novel therapeutic interventions for this tumor type. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630253 Thu, 26 Jan 2012 05:00:00 +0100 5630253 http://www.medworm.com/index.php?rid=5630252&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2180%2F12%2F18 Conclusions: This study demonstrated the genomic mosaicism of 'Ca. L. asiaticus' resulted from active DNA insertion/deletion activities. Analyses of strain variation depicted the significant inter- and intra-continent diversity of 'Ca. L. asiaticus'. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630252 Thu, 26 Jan 2012 05:00:00 +0100 5630252 http://www.medworm.com/index.php?rid=5630251&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F72 Conclusions: We conclude that fleas may be responsible in the transmission of Y. pestis and that PCR may provide means of plague surveillance in the endemic areas of Zambia. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630251 Thu, 26 Jan 2012 05:00:00 +0100 5630251 http://www.medworm.com/index.php?rid=5630250&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.virologyj.com%2Fcontent%2F9%2F1%2F34 Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassue village in Cote d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassue virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova viru... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630250 Thu, 26 Jan 2012 05:00:00 +0100 5630250 http://www.medworm.com/index.php?rid=5630249&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.ojrd.com%2Fcontent%2F7%2F1%2F10 Conclusions: Our results indicate that preferential XCI leads to the favored expression of the mutant ABCD1 allele. This emerges as a general phenomenon in X-ALD carriers not related to the presence of symptoms. Our data support the postulated growth advantage of cells with the preferential expression of the mutant ABCD1 allele, but argue against the use of XCI pattern, ABCD1 allele-specific expression pattern and VLCFA plasma concentration as biomarkers to predict the development of symptoms in X-ALD carriers. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630249 Thu, 26 Jan 2012 05:00:00 +0100 5630249 http://www.medworm.com/index.php?rid=5630248&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2105%2F13%2F16 Conclusions: Our methods are applicable to a variety of data types with training set containing several hundreds to a few thousand documents. It is completely automatic and, thus can be readily incorporated to different workflow at different literature-based databases. We believe that the work presented here can contribute greatly to the tremendous task of automating the important yet labor-intensive biocuration effort. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630248 Thu, 26 Jan 2012 05:00:00 +0100 5630248 http://www.medworm.com/index.php?rid=5630247&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F103 The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research, Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demonstrate that co-expression of CXCR7 and CXCR4 results in inhibition of CXCL12-mediated invasion, reduced intravasation of tumor cells into the vasculature, and fewer lung metastases compared with parental tumors. The results of this study suggest the combination of small molecule inhibitors of CXCR4 and CXCR7 could dramatically reduce invasion, intravasation, and metastasis and could be highly beneficial for the treatment of invasive breast cancer. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5630247 Thu, 26 Jan 2012 05:00:00 +0100 5630247 http://www.medworm.com/index.php?rid=5610688&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F51 Conclusions: The collection of geographic locations in intervention trials should become a routine task. The results of public health research may highly depend on spatial relationships among the study subjects and between the study subjects and the environment, both natural and infrastructural.Trial registrationCurrent Controlled Trials ISRCTN62323832 (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5610688 Fri, 20 Jan 2012 05:00:00 +0100 5610688 http://www.medworm.com/index.php?rid=5610687&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F52 Conclusions: It is possible to conduct a meta-analysis using only Microsoft Excel. More important, to our knowledge this is the first description of a method for producing a statistically adequate but graphically appealing forest plot summarizing descriptive data, using widely available software. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5610687 Fri, 20 Jan 2012 05:00:00 +0100 5610687 http://www.medworm.com/index.php?rid=5610686&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F53 Conclusions: The high number of synonymous substitutions observed within the variable domains of ompA appears to be due to an increased mutation rate within this region of the genome, whereas the increase in nucleotide substitution rate and the lack of phylogenetic congruence in the regions flanking ompA are characteristic motifs of gene conversion. Together, the increased mutation rate in the ompA gene, in conjunction with gene conversion and positive selection, results in a high degree of variability that promotes host immune evasion. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5610686 Fri, 20 Jan 2012 05:00:00 +0100 5610686 http://www.medworm.com/index.php?rid=5610685&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F16%2F1%2F301 Conclusions: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5610685 Fri, 20 Jan 2012 05:00:00 +0100 5610685 http://www.medworm.com/index.php?rid=5599123&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F13%2F25 Conclusions: The transcriptional architecture of S. Typhimurium and finer definition of the key role ppGpp plays in regulating Salmonella coding and non-coding transcription should promote the understanding of gene regulation in this important food borne pathogen and act as a resource for future research. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5599123 Tue, 17 Jan 2012 05:00:00 +0100 5599123 http://www.medworm.com/index.php?rid=5599122&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F13%2F26 In this study, we monitored the gene expression of 13 tissue samples harvested from a rapid autopsy heart (non-failed heart) and 7 from a cardiac explant (failed heart) through 24 hours of autolysis. The 24 hour autopsy simulation was designed to reflect a typical autopsy scenario where a body may begin cooling to ambient temperature for ~12 hours, before transportation and storage in a refrigerated room in a morgue. In addition, we also simulated a scenario wherein the body was left at room temperature for up to 24 hours before being found. A small fraction ( (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5599122 Tue, 17 Jan 2012 05:00:00 +0100 5599122 http://www.medworm.com/index.php?rid=5599121&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F13%2F27 Conclusions: We found striking differences among tissues in methylation, which were apparent at the chromosomal scale and when genes and transposable elements were examined. In contrast to other studies in plants, gene body methylation had a more repressive effect on transcription than promoter methylation. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5599121 Tue, 17 Jan 2012 05:00:00 +0100 5599121 http://www.medworm.com/index.php?rid=5599120&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F34 The objective of this study was to determine the effect of maternal Body Mass Index (BMI) on pregnancy outcomes. Methods: 1000 pregnant women were enrolled in the study. In order to explore the relationship between maternal first trimester Body Mass Index and pregnancy outcomes, participants were categorized into five groups based on their first trimester Body Mass Index. The data were analyzed using Pearson Chi-square tests in SPSS 18. Differences were considered significant if p (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5599120 Tue, 17 Jan 2012 05:00:00 +0100 5599120 http://www.medworm.com/index.php?rid=5599119&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F35 Conclusions: The proposed image analysis algorithm demonstrates the feasibility of automatically extracting tumour regions from digitized basal cell carcinoma histology slides. The proposed algorithm may be adaptable to other stain combinations and tumour types. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5599119 Tue, 17 Jan 2012 05:00:00 +0100 5599119 http://www.medworm.com/index.php?rid=5599118&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F16%2F1%2F404 - (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5599118 Tue, 17 Jan 2012 05:00:00 +0100 5599118 http://www.medworm.com/index.php?rid=5583802&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2148%2F12%2F4 Conclusions: These results suggest that the differences in the Kunitz/BPTI family between soft and hard ticks may be linked to the evolution of long-term blood feeding in hard ticks. In Ixodes, the lineage-specific expanded genes (Group II and III) lost the ancient function of inhibiting serine proteases and evolved new functions to adapt to long-term blood feeding. Therefore, these genes may play a profound role in the long-term blood feeding of hard ticks. Based our analysis, we propose that the six genes identified in our study may be candidate target genes for tick control. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5583802 Sat, 14 Jan 2012 05:00:00 +0100 5583802 http://www.medworm.com/index.php?rid=5583801&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.hqlo.com%2Fcontent%2F10%2F1%2F7 Conclusions: The OHIP-14 is a reliable and valid questionnaire for the assessment of OHRQoL among adults in Greece. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5583801 Sat, 14 Jan 2012 05:00:00 +0100 5583801 http://www.medworm.com/index.php?rid=5583800&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F16 Conclusions: IV bevacizumab was well tolerated in selected HCC subjects undergoing TACE, and appeared to diminish neovessel formation at week 14.Trial registrationClinicalTrials.gov NCT00049322. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5583800 Sat, 14 Jan 2012 05:00:00 +0100 5583800 http://www.medworm.com/index.php?rid=5583799&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F30 Conclusions: Substantially higher delivery care expenses were incurred for caesarean section compared to vaginal delivery. Three-fourths of the women who were not insured needed to be responsible for their own health care payment. Women who had higher family incomes were able to pay for more non-medical care expenses. The effect of health insurance on service utilization was noted by women and SBAs. To achieve the goal of utilizing delivery care in the hospitals, coverage of health insurance needs to be expanded. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5583799 Sat, 14 Jan 2012 05:00:00 +0100 5583799 http://www.medworm.com/index.php?rid=5583798&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F5%2F1%2F31 Conclusions: VPA can be used as an automatic pipeline to prioritize variants for further functional exploration and hypothesis generation. The package is implemented in the R language and is freely available from http://vpa.r-forge.r-project.org. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5583798 Sat, 14 Jan 2012 05:00:00 +0100 5583798 http://www.medworm.com/index.php?rid=5561640&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2202%2F13%2F5 Conclusions: These results indicate that the effects of fluoxetine in middle-aged rats are different to those previously described in young-adult animals, being more restricted in the mPFC and even following an opposite direction in the amygdala or the subventricular zone. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5561640 Thu, 05 Jan 2012 05:00:00 +0100 5561640 http://www.medworm.com/index.php?rid=5561639&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F7 Conclusions: In all genetic models, the association between the TERT rs2736100 polymorphism and cancer risk was significant. This meta-analysis suggests that the TERT rs2736100 polymorphism may be a risk factor for cancer. Further functional studies between this polymorphism and cancer risk are warranted. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5561639 Thu, 05 Jan 2012 05:00:00 +0100 5561639 http://www.medworm.com/index.php?rid=5553146&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.behavioralandbrainfunctions.com%2Fcontent%2F7%2F1%2F50 Conclusions: Our findings suggest that PDTC can suppress the maternal immune response induced by PolyI:C and partially prevent neurodevelopmental disorders of adult offspring. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5553146 Sat, 31 Dec 2011 05:00:00 +0100 5553146 http://www.medworm.com/index.php?rid=5553145&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.behavioralandbrainfunctions.com%2Fcontent%2F7%2F1%2F51 Conclusions: Our study provides further support for the importance of the COMT in alcohol dependence in addition to schizophrenia. It is possible that the rs165774 SNP, in combination with rs4680, results in a common molecular variant of COMT that contributes to schizophrenia and alcohol dependence susceptibility. This is potentially important for future studies of comorbidity. As our participant numbers are limited our observations should be viewed with caution until they are independently replicated. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5553145 Sat, 31 Dec 2011 05:00:00 +0100 5553145 http://www.medworm.com/index.php?rid=5553144&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2199%2F12%2F53 Conclusion: NlFoxA plays an important role in regulation of fecundity and development of ovaries in the BPH via regulating vitellogenin expression. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5553144 Sat, 31 Dec 2011 05:00:00 +0100 5553144 http://www.medworm.com/index.php?rid=5553143&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F248 Conclusions: The genotypic and allelic frequencies of rs16996148 SNP and the associations of the SNP and serum lipid levels are different in the Mulao and Han populations. Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is also observed in the both ethnic groups. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5553143 Sat, 31 Dec 2011 05:00:00 +0100 5553143 http://www.medworm.com/index.php?rid=5553147&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fgenomemedicine.com%2Fcontent%2F3%2F12%2F79 Ganapathi and Bukowski discuss the advances and pitfalls of a recent study of single nucleotide polymorphisms to predict the activity or toxicity of sunitinib for clear cell renal cell carcinoma. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5553147 Fri, 30 Dec 2011 05:00:00 +0100 5553147 http://www.medworm.com/index.php?rid=5545393&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.virologyj.com%2Fcontent%2F8%2F1%2F560 Conclusion: Results from the study suggest that only quercetin demonstrated significant anti-DENV-2 inhibitory activities. Other bioflavonoids, including daidzein, naringin and hesperetin showed minimal to no significant inhibition of DENV-2 virus replication. These findings, together with those previously reported suggest that select group of bioflavonoids including quercetin and fisetin, exibited significant inhibitory activities against dengue virus. This group of flavonoids, flavonol, could be investigated further to discover the common mechanisms of inhibition of dengue virus replication. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545393 Wed, 28 Dec 2011 05:00:00 +0100 5545393 http://www.medworm.com/index.php?rid=5545392&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.virologyj.com%2Fcontent%2F8%2F1%2F561 Conclusions: These results suggest that the cellular machinery for DNA replication in differentiated tissues of older leaves cannot be reprogrammed by Rep alone but may need other uncharacterised viral and plant factors. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545392 Wed, 28 Dec 2011 05:00:00 +0100 5545392 http://www.medworm.com/index.php?rid=5545391&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F564 Conclusions: Altogether this study provides additional insights into the structural and functional evolution of unusual introns harboring a 3' extension and lends further evidence that these introns are mobile with their extension. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545391 Wed, 28 Dec 2011 05:00:00 +0100 5545391 http://www.medworm.com/index.php?rid=5545390&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F565 Conclusions: In summary, this is a completely linear, quantitative HRM PCR method developed for the measurement of LINE-1 methylation. This cost-efficient, refined and reproducible assay can be performed using minimal amounts of starting DNA. These features make our assay suitable for high throughput analysis of multiple samples from large population-based studies. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545390 Wed, 28 Dec 2011 05:00:00 +0100 5545390 http://www.medworm.com/index.php?rid=5545389&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F566 Conclusion: In no case the hospitals from India and Iran are found scoring close to the benchmarks (Baldrige health care criteria for performance excellence 2009-10 and the guidelines proposed by the American Hospitals Association for hospitals). These results suggested to health care services more attempt to achieve high quality in management and performance. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545389 Wed, 28 Dec 2011 05:00:00 +0100 5545389 http://www.medworm.com/index.php?rid=5545388&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F595 Conclusions: We suggest that before tracheostomy, the anatomic relationship between the trachea and brachiocephalic artery must be confirmed by contrast-enhanced chest computed tomography scan. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545388 Wed, 28 Dec 2011 05:00:00 +0100 5545388 http://www.medworm.com/index.php?rid=5545387&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F596 Conclusions: Since giant cell tumor is a bone neoplasm that has major implications for the patient, the standard laboratory tests in patients with bone lesions are important for a correct diagnosis. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545387 Wed, 28 Dec 2011 05:00:00 +0100 5545387 http://www.medworm.com/index.php?rid=5545386&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F12%2F633 Conclusions: Our findings demonstrate a replication initiation system with novel features and underscore the functional diversity within the budding yeasts. Furthermore, we have developed new approaches for analyzing biologically functional DNA sequences with ill-defined motifs. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545386 Wed, 28 Dec 2011 05:00:00 +0100 5545386 http://www.medworm.com/index.php?rid=5545385&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fgenomebiology.com%2F2011%2F12%2F12%2F235 Sun and Kim review progress in the study of biological network evolution, with a focus on the protein-protein interaction network (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5545385 Wed, 28 Dec 2011 05:00:00 +0100 5545385 http://www.medworm.com/index.php?rid=5538956&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.intarchmed.com%2Fcontent%2F4%2F1%2F41 Conclusion: Namibia's expenditure on reproductive health is remarkable by the standards of Africa and other middle-income countries. However, an increasing maternal mortality ratio does not bode well with the level of reproductive health expenditure. It is therefore important to critically examine the state of efficiency in the allocation and use of reproductive health expenditures in order to improve health outcomes. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5538956 Sat, 24 Dec 2011 05:00:00 +0100 5538956 http://www.medworm.com/index.php?rid=5538955&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.cardiothoracicsurgery.org%2Fcontent%2F6%2F1%2F165 Conclusions: This simple technique is satisfactorily effective and does not result in any complications. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5538955 Sat, 24 Dec 2011 05:00:00 +0100 5538955 http://www.medworm.com/index.php?rid=5538954&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2229%2F11%2F180 Conclusions: This study has provided an overview of genes expressed during sesame seed development. This collection of sesame full-length cDNAs covered a wide variety of genes in seeds, inparticular, candidate genes involved in biosynthesis of sesame oils and lignans. These EST sequences enriched with full length will contribute to comparative genomic studies on sesame and other oilseed plants and serve as an abundant information platform for functional marker development and functional gene study. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5538954 Sat, 24 Dec 2011 05:00:00 +0100 5538954 http://www.medworm.com/index.php?rid=5538953&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jneuroinflammation.com%2Fcontent%2F8%2F1%2F182 Conclusions: Our data indicate that absence of MCPIP1 exacerbates ischemic brain damage by upregulation of proinflammatory cytokines and that MCPIP1 participates in LPS-induced ischemic stroke tolerance. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5538953 Sat, 24 Dec 2011 05:00:00 +0100 5538953 http://www.medworm.com/index.php?rid=5538952&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2105%2F12%2F492 Conclusion: The R package QuACN is under ongoing development and we add promising groups of topological network descriptors continuously. The package can be used to answer intriguing research questions in network biology, e.g., classifying biological data or identifying meaningful biological features, by analyzing the topology of biological networks. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5538952 Sat, 24 Dec 2011 05:00:00 +0100 5538952 http://www.medworm.com/index.php?rid=5538951&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.virologyj.com%2Fcontent%2F8%2F1%2F559 Prion diseases are transmissible, progressive and invariably fatal neurodegenerative conditions associated with misfolding and aggregation of a host-encoded cellular prion protein, PrPC. They have occurred in a wide range of mammalian species including human. Human prion diseases can arise sporadically, be hereditary or be acquired. Sporadic human prion diseases include Cruetzfeldt-Jacob disease (CJD), fatal insomnia and variably protease-sensitive prionopathy. Genetic or familial prion diseases are caused by autosomal dominantly inherited mutations in the gene encoding for PrPC and include familial or genetic CJD, fatal familial insomnia and Gerstmann-Straussler-Scheinker syndrome. Acquired human prion diseases account for only 5% of cases of human prion disease. They include kuru, iatrog... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5538951 Sat, 24 Dec 2011 05:00:00 +0100 5538951 http://www.medworm.com/index.php?rid=5538950&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F562 Background: Worldwide 15.5% of neonates are born with low birth weight, 95.6% of them in the developing countries. Prematurity accounts for 10% of neonatal mortality globally.The purpose was to evaluate the effects of birth weight and gender on neonatal outcome.FindingsThe data of 278 neonates managed in the Special Care Baby Unit (SCBU) of Jos University Teaching Hospital (JUTH) over a 2 year period from July 2006 to June 2008 were analyzed. One hundred and fifty nine (57.2%) were males and 119(42.8%) females. There were 87(31.3%) preterm and 191 (68.7%) term babies. Twelve of the babies died. Seven (2.52%) and 5 (1.80%) being males and females respectively. The neonatal mortality rate by gender was not significant (p > 0.05). The neonatal mortality was 25.2 deaths per 1000 live births fo... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5538950 Sat, 24 Dec 2011 05:00:00 +0100 5538950 http://www.medworm.com/index.php?rid=5516191&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.malariajournal.com%2Fcontent%2F10%2F1%2F374 Analysis of a large number of field isolates of P. vivax from India, Thailand and Colombia and few strains from other regions. The authors have contradicted the two lineages hypothesis as they found the similar distribution of both the Old World and New World lineages in the isolates from the different geographical regions. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516191 Mon, 19 Dec 2011 05:00:00 +0100 5516191 http://www.medworm.com/index.php?rid=5516190&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2105%2F12%2F482 Conclusions: A hierarchical application of SVM algorithms with cost sensitive output weighting enabled high quality reference classification with few serious misclassifications. This enabled us to significantly reduce the manual component of abstract categorization. Our findings are relevant to other databases that are developing their own document classifier schema and the datasets we make available provide large scale real-life benchmark sets for method developers. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516190 Mon, 19 Dec 2011 05:00:00 +0100 5516190 http://www.medworm.com/index.php?rid=5516189&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F522 Conclusions: Our results showed that reduced HSD17B1 expression can be associated with DNA methylation in the 5' flanking region of HSD17B1 in CRC from the proximal colon. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516189 Mon, 19 Dec 2011 05:00:00 +0100 5516189 http://www.medworm.com/index.php?rid=5516188&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F545 Conclusions: rs1424954 was not associated to pre-eclampsia in the Finnish study population. We hypothesise that while the gene associates to pre-eclampsia worldwide, the causative polymorphism in ACVR2A may be unique in genetically differing populations. Further research is needed to characterise the haplotype structure of ACVR2A in order for the causative genetic variant to be identified. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516188 Mon, 19 Dec 2011 05:00:00 +0100 5516188 http://www.medworm.com/index.php?rid=5516187&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F580 Conclusion: An intracranial extramedullary hematopoiesis, although extremely rare, should be considered as a potential ancillary diagnosis in any thalassemic patient and therefore appropriate studies should be performed to investigate the probable intracranial ectopic marrow before any surgical intervention. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516187 Mon, 19 Dec 2011 05:00:00 +0100 5516187 http://www.medworm.com/index.php?rid=5516186&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F581 Conclusion: Brain parenchyma containing an arachnoid cyst is vulnerable to trauma and increases the risk of serious hemorrhagic complications. We also suggest that the abnormal shape of the head should be considered as an indication for a computerized tomography scan in cases of mild head injury. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516186 Mon, 19 Dec 2011 05:00:00 +0100 5516186 http://www.medworm.com/index.php?rid=5516185&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F582 Conclusion: Although coronary thrombosis is a rare event in patients with fibrinogen deficiency, this condition is of major interest in view of the difficulties observed in managing these patients. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516185 Mon, 19 Dec 2011 05:00:00 +0100 5516185 http://www.medworm.com/index.php?rid=5516184&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F12%2F610 Conclusions: Variation of expression across the strains allowed us to find many novel gene-interaction networks in both T cell subsets. In addition, these two data sets enabled us to identify many differentially expressed genes and to nominate candidate genes that may have important functions for the maintenance of self-tolerance and the prevention of allergy. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5516184 Mon, 19 Dec 2011 05:00:00 +0100 5516184 http://www.medworm.com/index.php?rid=5506503&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jneuroinflammation.com%2Fcontent%2F8%2F1%2F176 Conclusion: Cytotoxic stress caused by PDT, at levels that do not cause overt tissue damage, induces VEGF and activates Akt to rescue the neural tissue, suppressing BAX. Thus, the immediate and transient induction of VEGF after PDT is neuroprotective. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5506503 Fri, 16 Dec 2011 05:00:00 +0100 5506503 http://www.medworm.com/index.php?rid=5506502&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1752-0509%2F5%2F199 Conclusion: The genomic clustering of miRNAs is closely related to the coordinated regulation in the gene regulatory network. The pattern of regulatory coordination is dependent on the composition of the miRNA cluster. The homo-clustered miRNAs mainly coordinate their regulation rapidly, while the hetero-clustered miRNAs exert control with a delay. The diverse pattern of regulatory coordination suggests distinct roles of the homo-clustered and the hetero-clustered miRNAs in biological processes. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5506502 Fri, 16 Dec 2011 05:00:00 +0100 5506502 http://www.medworm.com/index.php?rid=5506501&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2148%2F11%2F361 Conclusions: Simple coarse-grained models of protein folding can describe some natural features of evolving proteins but are currently not accurate enough to use in evolutionary inference. This is partly due to improper packing of the hydrophobic core. We suggest possible improvements on the representation of structure, folding energy, and binding function, as regards both native and non-native conformations, and describe a large number of possible applications for such a model. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5506501 Fri, 16 Dec 2011 05:00:00 +0100 5506501 http://www.medworm.com/index.php?rid=5506500&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2148%2F11%2F362 Monkeys that spend time grooming each other develop similar call patterns, irrespective of genetic relatedness, revealing the effect that social interactions have on vocal calls and providing clues to the evolution of human speech. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5506500 Fri, 16 Dec 2011 05:00:00 +0100 5506500 http://www.medworm.com/index.php?rid=5506499&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.malariajournal.com%2Fcontent%2F10%2F1%2F370 This study examines the relative prevalence of submicroscopic level parasite carriage and clonal complexity of infections (multiplicity of infection) over a range of endemicities in a region of north-east Tanzania, where altitude is an established proxy of malaria transmission. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5506499 Fri, 16 Dec 2011 05:00:00 +0100 5506499 http://www.medworm.com/index.php?rid=5506498&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F578 Conclusion: Some unusually located extra-uterine leiomyomata have been reported; retroperitoneal leiomyoma being among them. The origin of such tumors is still obscure; a parasitic origin as well as Mullerian cell rests or smooth muscle cells in the retroperitoneal vessels wall have been suggested. An 'iatrogenic' origin for such growths is also a possible theory. The origin of uncommonly located leiomyomata is an unexplored issue that merits more investigation. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5506498 Fri, 16 Dec 2011 05:00:00 +0100 5506498 http://www.medworm.com/index.php?rid=5506497&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F579 Conclusion: Intravesical gossypibomas are rare and can mimic a bladder mass. This is one of the few reported cases of cystoscopic removal. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5506497 Fri, 16 Dec 2011 05:00:00 +0100 5506497 http://www.medworm.com/index.php?rid=5495750&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F532 DiscussionWe embrace a wide range of scientific methodologies to evaluate the INA project and obtain information on mechanisms and contexts that will be valuable for decision making on local and national levels. The study will lead to a better understanding of how to provide support via social networks for the frail elderly and add to the knowledge on the feasibility and cost-effectiveness of the program in maintaining or improving their well-being. Last, the study will highlight the factors that determine the program's success or failure. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5495750 Tue, 13 Dec 2011 05:00:00 +0100 5495750 http://www.medworm.com/index.php?rid=5495749&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F533 Conclusions: Our study represents the first attempt to elucidate the whole-genome phylogeny of the 2011 German outbreak using an alignment-free method, and suggested a direct line of ancestry leading from a putative EAEC-like ancestor through the 2001 strain to the 2011 outbreak strain. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5495749 Tue, 13 Dec 2011 05:00:00 +0100 5495749 http://www.medworm.com/index.php?rid=5495748&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.virologyj.com%2Fcontent%2F8%2F1%2F533 Conclusions: The evolution of HN gene in the present HPIV1 isolates was relatively slow. The ML method may be a useful phylogenetic method to estimate the evolutionary time scale of HPIV and other viruses.KeywordsHuman parainfluenza virus, Maximum likelihood (ML) method, Phylogenetic analysis (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5495748 Tue, 13 Dec 2011 05:00:00 +0100 5495748 http://www.medworm.com/index.php?rid=5495747&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.virologyj.com%2Fcontent%2F8%2F1%2F534 Conclusions: We report the first construction and characterization of an infectious cDNA clone of CVA16. The availability of this infectious clone will greatly enhance future virological investigations and vaccine development for CVA16. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5495747 Tue, 13 Dec 2011 05:00:00 +0100 5495747 http://www.medworm.com/index.php?rid=5495746&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F12%2F600 Conclusion: The resources generated in this study provide new insights into the upstream pathways to the synthesis of prostratin and will likely facilitate functional studies aiming to produce larger quantities of this compound for HIV research and/or treatment of patients. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5495746 Tue, 13 Dec 2011 05:00:00 +0100 5495746 http://www.medworm.com/index.php?rid=5488222&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biotechnologyforbiofuels.com%2Fcontent%2F4%2F1%2F58 Conclusion: Taken together, these data suggest that transgenic rice can effectively serve as a bioreactor for large-scale production of active, thermostable cellulose hydrolytic enzymes. As a feedstock, direct expression of large amount of cellulases in transgenic rice may also facilitate saccharification of cellulose in rice straw and significantly reduce the costs for hydrolytic enzymes. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5488222 Sat, 10 Dec 2011 05:00:00 +0100 5488222 http://www.medworm.com/index.php?rid=5488221&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedical-engineering-online.com%2Fcontent%2F10%2F1%2F106 Conclusions: The proposed tomosynthesis technique can improve image contrast with aids of 3D whole volume CT images. Even though local tomosynthesis needs extra 3D CT scanning, it may find clinical applications in special situations in which extra 3D CT scan is already available or allowed. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5488221 Sat, 10 Dec 2011 05:00:00 +0100 5488221 http://www.medworm.com/index.php?rid=5488220&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2FR292 IntroductionThe incidence of vitamin D deficiency in critically ill patients has been reported to range from as low as 17% to 79%. Data regarding the relationship between 25-hydroxyvitamin D levels and outcomes in the medical intensive care unit are sparse. The goal of the study was to evaluate the prevalence of 25-hydroxyvitamin D deficiency in the medical intensive care unit and its relationship with outcomes.MethodThis was a retrospective study in a medical intensive care unit (MICU) at an inner city community hospital. The study period was between October 2009 and February 2010. Results: Of the 932 patients admitted during the study period, 25-hydroxyvitamin D vitamin D [(25(OH)D] levels were available in 523 (53%) patient; 86 of them were excluded from the study due to readmission to ... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5488220 Sat, 10 Dec 2011 05:00:00 +0100 5488220 http://www.medworm.com/index.php?rid=5488223&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2F316 Conclusion: In a collaborative network of community ICUs, a multi-faceted quality improvement intervention improved adoption of care practices. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5488223 Fri, 09 Dec 2011 05:00:00 +0100 5488223 http://www.medworm.com/index.php?rid=5477710&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2180%2F11%2F259 Conclusion: We conclude that the sHSPs encoded by the Afe_1437 and Afe_1009 genes are more likely to act as molecular chaperones in the A. ferrooxidans heat shock response. In addition, the three sHSPs from A. ferrooxidans are not recent paralogs, and the Afe_1437 and Afe_1009 genes could be inherited horizontally by A. ferrooxidans. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5477710 Wed, 07 Dec 2011 05:00:00 +0100 5477710 http://www.medworm.com/index.php?rid=5477709&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2474%2F12%2F277 DiscussionTen weeks post hip fracture only half of the participants were compliant to Standard Care. No follow-up for Standard Care or mobility recovery occurred. There is a need for rehabilitation and follow-up for mobility recovery after hip fracture. However, the effectiveness of the ProMo program can only be assessed at the end of the study.Trial registration: Current Controlled Trials ISRCTN53680197 (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5477709 Wed, 07 Dec 2011 05:00:00 +0100 5477709 http://www.medworm.com/index.php?rid=5477708&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2105%2F12%2F466 Conclusions: Our parallel algorithm and architecture accelerates large-scale MSA with reconfigurable computing and allows researchers to solve the larger problems that confront biologists today. Program source is available from http://dna.cs.byu.edu/msa/. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5477708 Wed, 07 Dec 2011 05:00:00 +0100 5477708 http://www.medworm.com/index.php?rid=5477707&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2105%2F12%2F467 Conclusions: Our comparisons indicate that four methods, DWD, EB, GQ, and XPN, are generally effective, while the remaining methods do not adequately correct for platform effects. Of the four successful methods, XPN generally shows the highest inter-platform concordance when treatment groups are equally sized, while DWD is most robust to differently sized treatment groups and consistently shows the smallest loss in gene detection. We provide an R package, CONOR, capable of performing the nine cross-platform normalization methods considered. The package can be downloaded at http://alborz.sdsu.edu/conor and is available from CRAN. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5477707 Wed, 07 Dec 2011 05:00:00 +0100 5477707 http://www.medworm.com/index.php?rid=5470068&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jfootankleres.com%2Fcontent%2F4%2F1%2F26 Conclusions This review indicates that there is good evidence (Level II) to suggest oral terbinafine is as safe and effective as itraconazole therapy for the treatment of onychomycosis in people with diabetes. Further research is needed to establish the evidence for other treatment modalities and treatment for tinea pedis for people with diabetes. Future efforts are needed to improve the efficacy of treatment intervention. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5470068 Sun, 04 Dec 2011 05:00:00 +0100 5470068 http://www.medworm.com/index.php?rid=5470070&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.veterinaryresearch.org%2Fcontent%2F42%2F1%2F117 A challenge experiment was performed to investigate whether administration of Mycobacterium avium subsp. paratuberculosis (MAP) via the respiratory route leads to MAP infection in calves. Eighteen calves from test negative dams were randomly allocated to four groups. Six calves were challenged with MAP nasally and six calves were challenged by transtracheal injection; three orally challenged calves served as positive controls, and three non challenged calves as negative controls. The challenge was performed as a nine-fold trickle dose, 10^7 CFU in total. Blood and faecal samples were collected frequently. Calves were euthanized three months post-challenge and extensively sampled. Blood samples were tested for the presence of antibodies and interferon gamma producing cells by ELISA. Faecal ... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5470070 Sat, 03 Dec 2011 05:00:00 +0100 5470070 http://www.medworm.com/index.php?rid=5470069&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-230X%2F11%2F133 Conclusions: An ethnic-specific MLH1 mutation spectrum occurred in Chinese gastric cancer patients. The MLH1 2101C>A mutation could be a marker for susceptibility to gastric cancer, particularly in males. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5470069 Sat, 03 Dec 2011 05:00:00 +0100 5470069 http://www.medworm.com/index.php?rid=5470072&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2F1007 Sepsis continues to pose a clear challenge as one of the most difficult and costly problems to treat and prevent. Sepsis is caused by systemic or localized infections that damage the integrity of microcirculation in multiple organs. The challenge of sepsis and its long-term sequelae was addressed by the National Institutes of Health National Heart Lung and Blood Institute Division of Blood Diseases and Resources. Defining sepsis as severe endothelial dysfunction syndrome that causes multiorgan failure in response to intravascular or extravascular microbial agents, the National Heart Lung and Blood Institute panel proposed the concept of genome wars as a platform for new diagnostic, therapeutic, and preventive approaches to sepsis. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5470072 Fri, 02 Dec 2011 05:00:00 +0100 5470072 http://www.medworm.com/index.php?rid=5470071&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2F1015 The nutrition dose truly absorbed by a patient is crucial information in the management or the investigation of nutrition during critical illness. In the present issue of Critical Care, assessment of nutritional losses in stools was studied. These losses together with enteral nutrition lost in gastric fluids and enteral nutrition prescribed but never infused make up the difference between the dose supposedly given to a patient and the amount effectively taken up. Additionally, the optimal dosing and timing of nutrition during critical illness are still debated. When enteral nutrition is insufficient, the options are limited. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5470071 Fri, 02 Dec 2011 05:00:00 +0100 5470071 http://www.medworm.com/index.php?rid=5459222&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.translational-medicine.com%2Fcontent%2F9%2F1%2F205 Conclusions: Our results suggest that AEG-1 expression is associated with SGC progression and may represent a novel and valuable predictor for prognostic evaluation of SGC patients. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5459222 Thu, 01 Dec 2011 05:00:00 +0100 5459222 http://www.medworm.com/index.php?rid=5459221&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2F457 We report a patient with profound metabolic acidosis that resolved rapidly after thiamine infusion. Thiamine deficiency is common in malnourished patients and is afflicted with high morbidity and mortality if untreated. Intensivists should have an increased awareness of this condition and a low threshold to infuse thiamine in patients at risk, especially before intravenous nutrition with a high percentage of glucose is initiated. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5459221 Thu, 01 Dec 2011 05:00:00 +0100 5459221 http://www.medworm.com/index.php?rid=5442793&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F219 Conclusions: The present results support the presence of two hepatopancreatic intracellular and extracellular PLA2 in the prosobranchs gastropods molluscs, Littorina littorea and Buccinum undatum and bring insights on their localizations. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5442793 Fri, 25 Nov 2011 05:00:00 +0100 5442793 http://www.medworm.com/index.php?rid=5442792&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2FR284 This study tested the hypothesis that levels of adhesion molecules are substantially increased after ICH and decreased thereafter, and that they can predict treatment outcomes. Methods: 239 blood samples were collected from 60 consecutive patients admitted within 24 hours after onset of spontaneous ICH and 60 blood samples were collected from 60 volunteer subjects. The additional samples were obtained on Day4, 7, 10 and 14 after onset of ICH irrespective of clinical deterioration. Results: Upon discharge, the therapeutic outcomes among the 60 spontaneous ICH cases as determined by modified Rankin Disability Scale (mMRS) showed that seventeen had no any disability, and delayed cerebral infarction (DCI) developed in 8.3% of patients (5 of 60). Statistical analysis of the adhesion molecules b... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5442792 Fri, 25 Nov 2011 05:00:00 +0100 5442792 http://www.medworm.com/index.php?rid=5442791&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6874%2F11%2F53 Conclusion: The argument of medical intervention and technology at birth being an opposing factor to the humanization of birth was not seen to be an issue in the studied highly specialized university affiliated hospital. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5442791 Fri, 25 Nov 2011 05:00:00 +0100 5442791 http://www.medworm.com/index.php?rid=5442790&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F12%2F578 Conclusions: Our results raise important questions about interpreting regulatory module predictions obtained by finding clusters of conserved binding sites. Attribution of function to these sites and their cognate transcription factors may be incorrect even when modules are successfully identified. Our study underscores the importance of empirical validation of computational results even when these results are in line with expectation. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5442790 Fri, 25 Nov 2011 05:00:00 +0100 5442790 http://www.medworm.com/index.php?rid=5442789&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F19 This study was to examine Hong Kong public knowledge, attitudes and behaviours regarding self-medication, self-care and the role of pharmacists in self-care. Methods: A cross-sectional phone survey was conducted, inviting people aged 18 or older to complete a 37-item questionnaire that was developed based on the Thematic Household surveys in Hong Kong, findings of the health prorfessional focus group discussions on pharmacist-led patient self management and literature. Telephone numbers were randomly selected from residential phone directories. Trained interviewers invited eligible persons to participate using the "last birthday method". Associations of demographic characteristics with knowledge, attitudes and beliefs on self-medication, self-care and role of pharmacists, and spending on o... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5442789 Fri, 25 Nov 2011 05:00:00 +0100 5442789 http://www.medworm.com/index.php?rid=5442788&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.amb-express.com%2Fcontent%2F1%2F1%2F43 We screened various thermophiles for meso-diaminopimelate dehydrogenase (meso-DAPDH, EC 1.4.1.16), which catalyzes the NAD(P)-dependent oxidative deamination of meso-diaminopimelate, and found the enzyme in a thermophilic bacterium isolated from compost in Japan. The bacterium grew well aerobically at around 55C and was identified as Ureibacillus thermosphaericus strain A1. We purified the enzyme about 47-fold to homogeneity from crude cell extract using five successive purification steps. The molecular mass of the purified protein was about 80 kDa, and the molecule consists of a homodimer with the subunit molecular mass of about 40 kDa. The optimum pH and temperature for the catalytic activity of the enzyme are about 10.5 and 65degreesC, respectively. The enzyme is highly selective for me... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5442788 Fri, 25 Nov 2011 05:00:00 +0100 5442788 http://www.medworm.com/index.php?rid=5432684&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jissn.com%2Fcontent%2F8%2F1%2F21 This study examined whether post-exercise carbohydrate supplementation could restore the performance in the subsequent simulated wrestling match. The effect of branched-chain amino acids and arginine on glucose disposal and performance was also investigated. Nine well-trained male wrestlers participated in 3 trials in a random order. Each trial contained 3 matches with a 1-hr rest between match 1 and 2, and a 2-hr rest between match 2 and 3. Each match contained 3 exercise periods interspersed with 1-min rests. The subjects alternated 10-s all-out sprints and 20-s rests in each exercise period. At the end of match 2, 3 different supplementations were consumed: 1.2 g/kg glucose (CHO trial), 1 g/kg glucose + 0.1 g/kg Arg + 0.1 g/kg BCAA (CHO+AA trial), or water (placebo trial). The peak and ... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432684 Tue, 22 Nov 2011 05:00:00 +0100 5432684 http://www.medworm.com/index.php?rid=5432683&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jmedicalcasereports.com%2Fcontent%2F5%2F1%2F553 Conclusions: An alternative paradigm to determine a therapeutic strategy for a patient with lung cancer should be considered given the genetic heterogeneity and instability of tumor cells. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432683 Tue, 22 Nov 2011 05:00:00 +0100 5432683 http://www.medworm.com/index.php?rid=5432682&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F30%2F1%2F109 Conclusions: CDK8 and beta-catenin were expressed in colon cancer at a high frequency. CDK8 specific siRNA transfection down-regulated the expression of CDK8 in colon cancer cells, which was also associated with a decrease in the expression of beta-catenin Moreover, CDK8 specific siRNA inhibited the proliferation of colon cancer cells, promoted their apoptosis and arrested these cells in the G0/G1 phase. Interference of CDK8 might be an effective strategy through beta-catenin regulation of colon cancer. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432682 Tue, 22 Nov 2011 05:00:00 +0100 5432682 http://www.medworm.com/index.php?rid=5432681&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.hqlo.com%2Fcontent%2F9%2F1%2F101 Conclusions: The Neurological Fatigue Index for MND (NFI-MND) is a simple, easy-to-administer fatigue scale. It consists of an 8-item fatigue summary scale in addition to separate scales for measuring fatigue experienced as reversible muscular weakness and fatigue expressed as feelings of low energy and whole body tiredness. The underlying two factor structure supports the patient concept of fatigue derived from qualitative interviews in this population. All three scales were shown to be reliable and capable of interval level measurement. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432681 Tue, 22 Nov 2011 05:00:00 +0100 5432681 http://www.medworm.com/index.php?rid=5432680&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fgenomebiology.com%2F2011%2F12%2F11%2FR115 Sequencing of antibiotic resistant Streptococcus pneumoniae reveals an initial mutation in an iron permease conferring tolerance to antibiotic-induced accumulation of oxidants (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432680 Tue, 22 Nov 2011 05:00:00 +0100 5432680 http://www.medworm.com/index.php?rid=5432679&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.cardiab.com%2Fcontent%2F10%2F1%2F103 Conclusions: Circulating omentin-1 level was independently correlated with arterial stiffness and carotid plaque in type 2 diabetes, even after adjusting for other cardiovascular risk factors and detailed medication history. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432679 Tue, 22 Nov 2011 05:00:00 +0100 5432679 http://www.medworm.com/index.php?rid=5432678&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2377%2F11%2F148 Conclusions: Studies assessed as using more rigorous methods found that neuroHAART was effective in improving neurocognitive function and decreasing CSF viral load, but only two of those studies were adequately statistically powered. Because all of these studies were observational, they represent a less compelling evidence base than randomised control trials for assessing treatment effect. Therefore, large randomised trials are needed to determine the robustness of any neuroHAART effect. However, such trials must be longitudinal, include the full spectrum of HAND, ideally carefully control for co-morbidities, and be based on optimal neuropsychology methods. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432678 Tue, 22 Nov 2011 05:00:00 +0100 5432678 http://www.medworm.com/index.php?rid=5432677&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2288%2F11%2F154 Conclusions: The findings suggest that people may be able to self-identify generalised anxiety more accurately than depression based on a description of a prototypical case. However, levels of identification were lower than expected. Considerable benefits from this method of screening may ensue if our prototypes can be improved for Major Depressive Disorder, Social Phobia and Panic Disorder. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432677 Tue, 22 Nov 2011 05:00:00 +0100 5432677 http://www.medworm.com/index.php?rid=5432676&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2350%2F12%2F151 Conclusions: Based on our SNP and haplotype results, we delineate the model that IDE promoter and 3' untranslated region/downstream variation may have different effects on IDE expression, presumably a relevant endophenotype with disorder-specific effects on AD and T2DM susceptibility. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432676 Tue, 22 Nov 2011 05:00:00 +0100 5432676 http://www.medworm.com/index.php?rid=5432685&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fgenomemedicine.com%2Fcontent%2F3%2F11%2F73 Gymrek and Erlich discuss the success stories and challenges of translating genomic research into the clinic highlighted at the Cold Spring Harbor Laboratory meeting on 'Personal Genomes'. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5432685 Mon, 21 Nov 2011 05:00:00 +0100 5432685 http://www.medworm.com/index.php?rid=5423450&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.wjso.com%2Fcontent%2F9%2F1%2F151 We presented a case of primary hepatic carcinoid tumor in a 53-year-old female with a complaint of right upper abdominal pain. Computer tomography scans revealed a hypervascular mass in segment 4 of the liver. An ultrasonography-guided biopsy showed a carcinoid tumor. No other lesions were found by the radiological investigations. Surgery resection was performed and histopathological examination revealed a primary hepatic carcinoid tumor. Three years later, recurrence was found and transcatheter arterial chemoembolization was performed. After transcatheter arterial chemoembolization, the patient has been free of symptom and had no radiological disease progression for over 6 months. Surgical resection combination with transcatheter arterial chemoembolization is effective to offer excellent ... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423450 Sat, 19 Nov 2011 05:00:00 +0100 5423450 http://www.medworm.com/index.php?rid=5423449&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F215 Conclusions: Low HDL-C was significantly associated with acute coronary events, and triglyceride levels as well as renal function were inversely related to all-cause deaths after the coronary event. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423449 Sat, 19 Nov 2011 05:00:00 +0100 5423449 http://www.medworm.com/index.php?rid=5423448&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biotechnologyforbiofuels.com%2Fcontent%2F4%2F1%2F53 Conclusions: An OES of [AMIM]Cl and DMSO with chi [AMIM]Cl of 0.7 was chosen for cellulose pretreatment because it dissolved cellulose rapidly to achieve a high glucose yield (54.1%), which was only slightly lower than the value (59.6%) obtained using pure [AMIM]Cl. OES pretreatment is a cost-effective and environmentally friendly technique for hydrolysis, because it 1) uses the less expensive OES instead of pure ionic liquids, 2) shortens dissolution time, 3) requires lower energy for stirring and transporting, and 4) is recyclable. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423448 Sat, 19 Nov 2011 05:00:00 +0100 5423448 http://www.medworm.com/index.php?rid=5423447&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2148%2F11%2F338 Conclusions: Physical characteristics of the environment are an important factor in the evolution and diversification of the vertebrate eye. Both teleost reef fish and terrestrial amniotes meet the functional requirements of dim-light vision with a similar evolutionary response of morphological and optical modifications. The trade-off between improved dim-light vision and reduced optical diversity may be a key factor in explaining the lower trophic diversity of nocturnal reef teleosts. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423447 Sat, 19 Nov 2011 05:00:00 +0100 5423447 http://www.medworm.com/index.php?rid=5423454&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2FR273 Conclusions: Gene probes up-regulated in critically ill pediatric patients with septic shock may allow for the identification of novel candidate serum biomarkers for SSAKI prediction. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423454 Fri, 18 Nov 2011 05:00:00 +0100 5423454 http://www.medworm.com/index.php?rid=5423453&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2FR274 Conclusions: Single levels of CRP and WBC are not reliable for diagnosis of infections during SE, while their linear changes over time significantly correlated with the presence of infections. In addition, low levels of CRP and PCT rule out hospital-acquired infections in SE patients. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423453 Fri, 18 Nov 2011 05:00:00 +0100 5423453 http://www.medworm.com/index.php?rid=5423452&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fccforum.com%2Fcontent%2F15%2F6%2F454 In order to alert the potential risk for tracheobronchial misplacement of the feeding tube in those patients with endotracheal intubation or tracheostomy, we report tracheobronchial malposition of the feeding tube in six patients with mechanical ventilation from January 2008 to August 2011. Tracheobronchial misplacement of the feeding tube was found in two patients by bronchoscopy, chest radiography confirmed malposition of the tube in four patients. Neither auscultation of bubbling sounds over epigastrium after insufflation of air nor aspiration of "gastric content" is thought to be reliable. We should use pH test of gastric aspirate as the first line test, with pH between 1 and 5.5 as the safe range; and X-ray is used as the second line test. Cautions should be taken for interpretation o... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423452 Fri, 18 Nov 2011 05:00:00 +0100 5423452 http://www.medworm.com/index.php?rid=5423451&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fstemcellres.com%2Fcontent%2F2%2F6%2F44 In this review, we will describe the cardiac differentiation from ES cells, iPS cells, and the current progress of using iPS cell derived cardiomyocyte for heart disease modeling and for the development of therapeutic strategies. In addition, we will summarize the recent direct reprogramming of cardiomyocyte from fibroblast cells, which provides another method for potential heart disease therapy. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5423451 Fri, 18 Nov 2011 05:00:00 +0100 5423451 http://www.medworm.com/index.php?rid=5409974&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.nutritionandmetabolism.com%2Fcontent%2F8%2F1%2F80 Conclusions: These findings demonstrated that delayed wound healing is associated with an inflammatory response induced by hyperglycaemia, and suggests that dietary antioxidant supplementation may have beneficial effects on wound healing through selective modulation of blood glucose levels, oxidative stress, and inflammatory response. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409974 Thu, 17 Nov 2011 02:55:01 +0100 5409974 http://www.medworm.com/index.php?rid=5409973&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fjcmr-online.com%2Fcontent%2F13%2F1%2F71 Background: Long acquisition times and complex breathing motion patterns lead to suboptimal image quality in whole heart coronary magnetic resonance angiography (WHCMRA). To overcome this problem, an abdominal belt (BELT) has been suggested by a Japanese group. However, its applicability in a Western population has not been previously demonstrated. The purpose of this study was to investigate 1) how the application of a BELT alters breathing patterns during MR scanning and 2) whether the BELT has a similar impact on breathing patterns in UK and Japanese patient populations. Methods: 30 patients (15 in the UK and 15 in Japan) were studied at 1.5 Tesla (Achieva, Philips Healthcare). Real time navigator positioned through the right diaphragm in cranio-caudal direction was evaluated. Measureme... BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409973 Thu, 17 Nov 2011 02:55:01 +0100 5409973 http://www.medworm.com/index.php?rid=5409972&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2474%2F12%2F260 Conclusion: Overall, this study suggests that school teachers are at a high risk of MSD. Further research, preferably longitudinal, is required to more thoroughly investigate the issue of MSD among teachers, with a greater emphasis on the possible wider use of ergonomic principles. This would represent a major step forward in the prevention of MSD among teachers, especially if easy to implement control measures could be recommended. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409972 Thu, 17 Nov 2011 02:55:01 +0100 5409972 http://www.medworm.com/index.php?rid=5409981&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fstemcellres.com%2Fcontent%2F2%2F6%2F46 Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409981 Wed, 16 Nov 2011 05:00:00 +0100 5409981 http://www.medworm.com/index.php?rid=5409980&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.occup-med.com%2Fcontent%2F6%2F1%2F29 Conclusions. At work, women are more subject to harassment (for personal aspects related to emotional and relational factors) than men. The knowledge of the phenomenon is an essential requisite to contrast bullying; prevention can be carried out only through effective information and training of workers and employers, who have the legal obligation to preserve the integrity of the mental and physical status of their employees during work. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409980 Wed, 16 Nov 2011 05:00:00 +0100 5409980 http://www.medworm.com/index.php?rid=5409979&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.etsmjournal.com%2Fcontent%2F3%2F1%2F15 Conclusions: BC- and EC-associated AT1aR are both involved in the brain injury responses to ischemic stroke during Ang II-hypertension, with EC AT1aR contributing more to the blood cell recruitment response and BC AT1Ra exerting a significant influence on the BBB disruption and tissue necrosis elicited by I/R. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409979 Wed, 16 Nov 2011 05:00:00 +0100 5409979 http://www.medworm.com/index.php?rid=5409978&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.bsd-journal.com%2Fcontent%2F2%2F1%2F13 Conclusions: The small non-coding RNA, most probably miRNA, specifically expressed in female mouse SMGs interfered with klk1b26 protein synthesis in the in vitro translation system. Therefore sexual dimorphism observed in klk1b26 expression in mouse SMGs is due at least in part to the female-specific small non-coding RNA in SMGs. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409978 Wed, 16 Nov 2011 05:00:00 +0100 5409978 http://www.medworm.com/index.php?rid=5409977&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Farthritis-research.com%2Fcontent%2F13%2F6%2FR185 Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409977 Wed, 16 Nov 2011 05:00:00 +0100 5409977 http://www.medworm.com/index.php?rid=5409976&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Farthritis-research.com%2Fcontent%2F13%2F6%2FR186 Conclusions: The replication analysis indicates that TNFAIP3, ETS1 and TNIP1 are likely common susceptibility genes for SLE in Chinese populations, and they may contribute to the pathogenesis of multiple SLE subphenotypes. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409976 Wed, 16 Nov 2011 05:00:00 +0100 5409976 http://www.medworm.com/index.php?rid=5409975&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Farthritis-research.com%2Fcontent%2F13%2F6%2FR187 Conclusions: Meniscal cell proliferation in vivo may be diminished following joint injury due to the upregulation of inflammatory cytokines, thereby limiting native cellular repair of meniscal lesions. Therefore, therapies that can promote meniscal cell proliferation have promise to enhance meniscal repair and improve tissue engineering strategies. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5409975 Wed, 16 Nov 2011 05:00:00 +0100 5409975 http://www.medworm.com/index.php?rid=5401546&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.ijbnpa.org%2Fcontent%2F8%2F1%2F125 Conclusion: More quasi-experiments that examine a broader range of environmental attributes in relation to context-specific physical activity and that measure changes in the built environment, neighborhood preferences and their effect on physical activity are needed. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5401546 Sun, 13 Nov 2011 05:00:00 +0100 5401546 http://www.medworm.com/index.php?rid=5401545&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2Fcontent%2F4%2F1%2F492 Conclusions: Findings clearly show that pathological gambling is associated with trait but not state impulsivity. In other words, pathological gambling is associated with an impulsivity stemming from enduring personality characteristics that lead gamblers to focus on short-term gains (trait impulsivity) rather than momentary cognitive or affective disinhibition (state impulsivity). Interventions should aim to change pathological gamblers' habitual functioning style by cultivating healthy reflection habits and focusing on long-term rewards. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5401545 Sun, 13 Nov 2011 05:00:00 +0100 5401545 http://www.medworm.com/index.php?rid=5401544&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2156%2F12%2F98 Conclusions: Results suggest testing multiple SNP-to-gene search spaces compensates for differences in phenotypes, populations and SNP platforms. Surprisingly, domain-based homology information was more informative when benchmarked against gene candidates reported by GWA studies compared to previously determined disease genes, possibly suggesting a larger contribution of gene homologs to complex diseases than Mendelian diseases. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5401544 Sun, 13 Nov 2011 05:00:00 +0100 5401544 http://www.medworm.com/index.php?rid=5401551&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.retrovirology.com%2Fcontent%2F8%2F1%2F93 This paper provides evidence that localization of the proteasome to TRIM5alpha cytoplasmic bodies makes an important contribution to TRIM5alpha-mediated restriction. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5401551 Sat, 12 Nov 2011 05:00:00 +0100 5401551 http://www.medworm.com/index.php?rid=5401550&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.jnrbm.com%2Fcontent%2F10%2F1%2F15 Conclusions: We weren't able to confirm the association between Lp(a) levels and AF recurrence, inflammation and left atrium diameter in patients after successful EC of persistent AF. Further studies are needed to elucidate the role of Lp(a) in this clinical setting. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5401550 Sat, 12 Nov 2011 05:00:00 +0100 5401550 http://www.medworm.com/index.php?rid=5401549&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2393%2F11%2F93 Conclusion: Based on our results, decision making among laypersons should use TTO or DCE; patients should use VAS or TTO. (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5401549 Sat, 12 Nov 2011 05:00:00 +0100 5401549 http://www.medworm.com/index.php?rid=5401548&cid=s_30439_22_f&fid=30439&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2164%2F12%2F555 We examined physiological differences and changes in gene expression in response to TFA and/or MSG consumption compared to a control diet, in male and female C57BL/6J mice. Results: Heart and % body weight increases were greater in TFA-fed mice, who also exhibited dysplipdemia (P (Source: BioMed Central) BioMed Central journals http://www.medworm.com/rss/comments.php?id=5401548 Sat, 12 Nov 2011 05:00:00 +0100 5401548