MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Bioinorganic Chemistry and Applications' source. Sun, 21 Mar 2010 16:57:39 +0100 http://www.medworm.com/index.php?rid=3353678&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2010%2F724210.html The utility of the extensible systematic force field (ESFF) was tested for copper(II) binding to a 34-amino-acid Cu(II) peptide, which includes five histidine residues and is the putative copper-binding site of lysyl oxidase. To improve computational efficiency, distance geometry calculations were used to constrain all combinations of three histidine ligands to be within bonding distance of the copper and the best results were utilized as starting structures for the ESFF computations. All likely copper geometries were modeled, but the results showed only a small dependence on the geometrical model in that all resulted in a distorted square pyramidal geometry about the copper, some of the imidazole rings were poorly oriented for ligation to the Cu(II), and the copper-nitrogen bond distances... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=3353678 Thu, 11 Mar 2010 17:39:14 +0100 3353678 http://www.medworm.com/index.php?rid=3341873&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F906836.html Three model dipeptides containing 3-(2,3-di(pyridin-2-yl)quinoxalin-6-yl)alanine, 3-(dipyrido[3,2-a:2,3-c]phenazin-11-yl)alanine, and 3-(2,3-diphenylquinoxalin-6-yl)alanine were studied with respect to their ability to bind selected transition metal ions, such as Cu(II), Fe(II), Ni(II), Co(II), Mn(II), and Cr(III). It was found that only Cu(II) and Fe(II) ions could form stable complex species with the studied compounds. The ability to form the complexes correlated well with DNA damage experiments. Only the ferrous and cupric complexes are capable of generating both single- and double-strand scissions. However, double-strand breakages appear to be dominating lesions in the presence of hydrogen peroxide, especially for copper(II) containing systems. The quantity of breakage products in the ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=3341873 Mon, 08 Mar 2010 17:30:27 +0100 3341873 http://www.medworm.com/index.php?rid=3211615&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F901563.html This study reports a new material for the removal of heavy metals from low-strength wastewater. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=3211615 Wed, 27 Jan 2010 16:02:03 +0100 3211615 http://www.medworm.com/index.php?rid=3106598&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F925297.html The composition and morphology of nanocrystals in urines of healthy persons and lithogenic patients were comparatively investigated by means of X-ray diffraction (XRD) and transmission electron microscopy (TEM). It was shown that the main composition of urinary nanocrystals in healthy persons were calcium oxalate dihydrate (COD), uric acid, and ammonium magnesium phosphate (struvite). However, the main compositions of urinary nanocrystals in lithogenic patients were struvite, β-tricalcium phosphate, uric acid, COD, and calcium oxalate monohydrate (COM). According to the XRD data, the size of nanocrystals was calculated to be 23∼72 nm in healthy urine and 12∼118 nm in lithogenic urine by Scherer formula. TEM results showed that the nanocrystals in healthy ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=3106598 Sun, 20 Dec 2009 15:45:03 +0100 3106598 http://www.medworm.com/index.php?rid=2971797&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F647873.html The new complexes [M2O5L2(H2O)2]⋅H2O (M=Mo,1;M=W,2), [RuL2(H2O)2]⋅H2O  (3), [ML3]⋅xH2O (M=Rh,x=2,4;M=Ir,x=1,5), [RhL2(PPh3)2](ClO4)⋅2H2O  (6), [PdL2]⋅2H2O  (7), [PdL(phen)]Cl⋅H2O  (8), [Re⁡OL2(PPh3)]Cl  (9) and [UO2L2]  (10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand field, NMR, mass) methods. The ligand L− is in its thione form and behaves as a bidentate chelate with the deprotonated (hydroxyl) oxygen and the nitrogen ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2971797 Sun, 08 Nov 2009 15:49:27 +0100 2971797 http://www.medworm.com/index.php?rid=2971796&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F702730.html A neutral compound Re(CO)3(L) (L: 2-((2-(2,6-diethylphenylamino)-2-oxoethyl)(2-ethoxy-2-oxoethyl)amino)acetic acid, an IDA analogue) has been synthesized and evaluated for in vitro imaging probes of β-amyloid (Aβ) aggregates. Results of X-ray measurement of Re(CO)3(L) demonstrated that the coordination mode of Re(CO)3(L) was different from that of classical Re/Tc(I) (tricarbonyl)-IDA analogues; the structure of Re(CO)3(L) was confirmed by means of infrared spectrum, HPLC-UV, TOF MS, and X-ray measurements (Cambridge Crystallographic Data Centre number is 732731): monoclinic P21/c, a=15.6636 (12) Å, b=10.9360 (8) Å, c=27.756 (2) Å, α=90.000 (0)∘, β=90.783 (5)∘, γ=90.000 (0)∘, and Z=8. The binding af... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2971796 Sun, 08 Nov 2009 15:49:27 +0100 2971796 http://www.medworm.com/index.php?rid=2926771&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F413175.html Three new Schiff bases of N-substituted isatin LI, LII, and LIII = Schiff base of N-acetylisatin, N-benzylisatin, and N-benzoylisatin, respectively, and their metal complexes C1a,b=[Co2(LI)2Cl3]Cl, C2=[Ni(LI)2Cl2]0.4BuOH, C3=[CuLICl(H2O)]Cl⋅0.5BuOH, C4=[Pd(LI)2Cl]Cl, C5=[Pt(L1)2Cl2]Cl2⋅1.8EtOH.H2O, C6a=[CoLIICl]Cl⋅0.4H2O⋅0.3DMSO, C6b=[CoLIICl]Cl⋅0.3H2O⋅0.1BuOH, C7=[NiLIICl2], C8=[CuLII]Cl2⋅H2O , C9=[Pd(LII)2]Cl2, C10=[Pt(LII)2.5Cl]Cl3, C11a=[Co(LIII)]C12⋅H2O, C11b=[Co(LIII)]Cl2⋅0.2H2O, and C12=[Ni(LIII)2]Cl2, C13=[Ni(LIII)2]Cl2 were reported. The complexes were characterized by elemental analyses, metal and chloride content, spectroscopic methods, magnetic moments, conductivity measurements, and thermal s... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2926771 Mon, 26 Oct 2009 16:23:40 +0100 2926771 http://www.medworm.com/index.php?rid=2875135&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F347872.html Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL2(H2O)2]⋅nH2O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD s... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2875135 Fri, 09 Oct 2009 11:06:39 +0100 2875135 http://www.medworm.com/index.php?rid=2836028&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F347359.html Fine structures of 8-G-1-(p-YC6H4C ≡ CSe)C10H6 [1 (G = H) and 2 (G = Cl): Y = H (a), OMe (b), Me (c), F (d), Cl (e), CN (f), and NO2 (g)] are determined by the X-ray analysis. Structures of 1, 2, and 3 (G = Br) are called A if each Se–Csp bond is perpendicular to the naphthyl plane, whereas they are B when the bond is placed on the plane. Structures are observed as A for 1a–c bearing Y of nonacceptors, whereas they are B for 1e–g with Y of strong acceptors. The change in the structures of 1e–g versus those of 1a–c is called Y-dependence in 1. The Y-dependence is very specific in 1 relative to 1-(p-YC6H4Se)C10H7 (4) due to the ethynyl group: the Y-dependence in 1 is almost inverse to the case of 4 due to the ethynyl group. We call the speci... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2836028 Sun, 27 Sep 2009 18:02:26 +0100 2836028 http://www.medworm.com/index.php?rid=2799853&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F303176.html Nanorods hydroxyapatite, (HAP) Ca10(PO4)6(OH)2 is successfully prepared by water in oil microemulsion using, CaCL2 and H3PO4 (water phase), poly(sodium 4-styrene sulfonate) (PSSS) as template and cyclohexane as oil phase. The nano-structure of the product was studied by means of X-ray diffraction (XRD), Fourier transmission infrared spectrometer (FT-IR), scanning electron microscopy (SEM), and atomic force microscope (AFM). With this system, we could synthesize nano-particles of hydroxyapatite with high crystallinity and least agglomeration. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2799853 Wed, 16 Sep 2009 17:46:59 +0100 2799853 http://www.medworm.com/index.php?rid=2770045&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F979680.html The absorption efficiency of any drug in blood is of prime importance. Compounds having the general formula: Kn[M(FO)2(H2O)2]⋅xH2O, where (M=Cu(II) or Fe(III), n=2 or 1 , FO=folate anion, x=2 or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined. The obtained compounds were characterized by elemental analysis, infrared as well as thermogravimetric analysis and polarization of light. The results suggest that the two folate complexes were formed in 1 : 2 molar ratio (metal : folic acid) which acted as a bidentate ligand through both carboxylic groups. Polarization of light proved that the folate complexes have symmetric geometry. Biological application proved that Cu(II) and Fe(III) complexes were absorbed more efficiently in rodent bl... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2770045 Sun, 06 Sep 2009 17:41:38 +0100 2770045 http://www.medworm.com/index.php?rid=2704956&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F512938.html The [Pd(DEEN)Cl2] and [Pt(DEEN)Cl2] complexes were synthesized and characterized where DEEN=N,N-diethylethylenediamine. The stoichiometry and stability of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and [Pd(DEEN)(H2O)2]2+ were investigated at 37∘C and 0.16 M ionic strength. The stability constant of the complexes formed in solution were determined and the binding centres of the ligands were assigned. The concentration distribution diagrams of the complexes were evaluated The equilibrium constants for the displacement of representative coordinated ligands such as inosine, glycine or methionine by cysteine were calculated and the concentration distribution diagrams of the various species wer... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2704956 Mon, 17 Aug 2009 11:30:05 +0100 2704956 http://www.medworm.com/index.php?rid=2694588&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F561091.html Dead dried Chlorella vulgaris was studied in terms of its performance in binding divalent copper, cadmium, and lead ions from their aqueous or 50% v/v methanol, ethanol, and acetone solutions. The percentage uptake of cadmium ions exhibited a general decrease with decrease in dielectric constant values, while that of copper and lead ions showed a general decrease with increase in donor numbers. Uptake percentage becomes less sensitive to solvent properties the larger the atomic radius of the biosorbed ion, and uptake of copper was the most affected. FT-IR analyses revealed stability of the biomass in mixed solvents and a shift in vibrations of amide(I) and (II), carboxylate, glucose ring, and metal oxygen upon metal binding in all media. ΔνCOO values (59–69 c... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2694588 Thu, 13 Aug 2009 12:14:53 +0100 2694588 http://www.medworm.com/index.php?rid=2673859&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F381925.html Nuclear couplings for the Se-Se bonds, J1(Se, Se), are analyzed on the basis of the molecular orbital (MO) theory. The values are calculated by employing the triple ζ basis sets of the Slater type at the DFT level. J1(Se, Se) are calculated modeled by MeSeSeMe (1a), which shows the typical torsional angular dependence on ϕ(CMeSeSeCMe). The dependence explains well the observed J1(Se, Se)obsd of small values (≤64 Hz) for RSeSeR′ (1) (simple derivatives of 1a) and large values (330–380 Hz) observed for 4-substituted naphto[1,8-c,d]-1,2-diselenoles (2) which correspond to symperiplanar diselenides. J1 (Se, Se : 2) becomes larger as the electron density on Se increases. The paramagnetic spin-orbit terms contribute predominantly. The contributions are ev... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2673859 Thu, 06 Aug 2009 12:11:45 +0100 2673859 http://www.medworm.com/index.php?rid=2663718&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F914105.html The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)2(H2O)2]3H2O(M=CuII, NiII or MnII) and [M(eno)(H2O)2]Cl⋅4H2O  (M=FeIII) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by MnII and CuII complexes exhibited potential to mediate anti-inflammatory response. ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2663718 Mon, 03 Aug 2009 12:11:53 +0100 2663718 http://www.medworm.com/index.php?rid=2572686&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F905320.html The synthesis and characterization of a novel ligand, bis[(2-ethyl-5-methyl-imidazo-4-yl)methyl]sulfide (bemims), as well as a bemims-containing copper(II) coordination complex are described. In this complex, [Cu(bemims)X2] with X=NO3-, bemims acts as a tridentate ligand and two monodentate nitrate ions complete the coordination sphere. Both imidazole N atoms and the thioether S atom of bemims participate in coordination. The Cu(II) ion is five-coordinated with a slightly distorted square-pyramidal geometry (τ=.09). Electrochemical studies and spectroscopic data for this complex are compared with some blue copper proteins in order to assess its ability to mimic the copper center of type I copper proteins. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2572686 Mon, 06 Jul 2009 11:53:47 +0100 2572686 http://www.medworm.com/index.php?rid=2572685&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F219818.html The sequestering ability of polyamines and aminoacids of biological and environmental relevance (namely, ethylenediamine, putrescine, spermine, a polyallylamine, a branched polyethyleneimine, aspartate, glycinate, lysinate) toward dimethyltin(IV) cation was evaluated. The stability of various dimethyltin(IV) / ligand species was determined in NaClaq at t=25∘C and at different ionic strengths (0.1≤I/mol L-1≤1.0), and the dependence of stability constants on this parameter was modeled by an Extended Debye-Hückel equation and by Specific ion Interaction Theory (SIT) approach. At I=0.1 mol L−1, for the ML species we have log K=10.8, 14.2, 12.0, 14.7, 11.9, 7.7, 13.7, and 8.0 for ethylenediamine, putrescine, polyallylamine, spermine, polyethyleneimine, gl... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2572685 Mon, 06 Jul 2009 11:53:47 +0100 2572685 http://www.medworm.com/index.php?rid=2503429&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F603651.html A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H2O]Cl·3H2O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by two N atoms from hsm, two O atoms from the quinolone, and one apical water oxygen. Alteration of bacterial DNA structure and/or associated functions in vivo by [Cu(hsm)(nal)H2O]Cl·3H2O was demonstrated by the induction of a recA-lacZ fusion integrated at the amyE locus of a recombinant Bacillus subtilis strain. Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double h... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2503429 Thu, 25 Jun 2009 08:46:07 +0100 2503429 http://www.medworm.com/index.php?rid=2467875&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2007%2F091078.abs.html The interaction of drugs with DNA is an important aspect in pharmacology. In recent years, many important technological advances have been made to develop new techniques to monitor biorecognition and biointeraction on solid devices. The interaction between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical properties of nucleobases. The propensity of a given compound to interact with DNA is measured as a function of the decrease of guanine oxidation signal on a DNA electrochemical biosensor. Covalent binding at N7 of guanine, electrostatic interactions, and intercalation are the events that this kind of biosensor can detect. In this context, the interaction between a panel of antitumoral Pt-, Ru-, and Ti-based metallodrugs with DNA... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467875 Wed, 10 Jun 2009 02:31:38 +0100 2467875 http://www.medworm.com/index.php?rid=2467874&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2007%2F051483.abs.html A series of metal complexes of Cu(II) and Ni(II) having the general composition [M(L)X2] with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467874 Wed, 10 Jun 2009 02:31:38 +0100 2467874 http://www.medworm.com/index.php?rid=2467873&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2007%2F010720.abs.html The 173–195 segment corresponding to the helix 2 of the C-globular prion protein domain could be one of several “spots” of intrinsic conformational flexibility. In fact, it possesses chameleon conformational behaviour and gathers several disease-associated point mutations. We have performed spectroscopic studies on the wild-type fragment 173–195 and on its D178N mutant dissolved in trifluoroethanol to mimic the in vivo system, both in the presence and in the absence of metal cations. NMR data showed that the structure of the D178N mutant is characterized by two short helices separated by a kink, whereas the wild-type peptide is fully helical. Both peptides retained these structural organizations, as monitored by CD, in the presence of metal cations. NMR spectra were... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467873 Wed, 10 Jun 2009 02:31:38 +0100 2467873 http://www.medworm.com/index.php?rid=2467872&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2007%2F030394.abs.html Terminally protected pentapeptides with 2 histidines (Ac-HHVGD-NH2 and Ac-HVGDH-NH2) and the terminally free peptides containing both internal aspartyl and C-terminal histidyl residues (FDAH and VIDAH) have been synthesized, and copper(II) complexes studied by potentiometric, UV-Vis, CD, and EPR spectroscopic techniques in solution. Both thermodynamic and spectroscopic data reveal that side chain donor atoms of aspartyl and histidyl residues have a significant contribution to the metal binding affinity of peptide molecules. In the case of terminally protected peptides, the role of the imidazole-N donor functions is reflected in the enhanced stability of the 3N and 4N coordinated copper(II) complexes. The amino and β-carboxylate groups of FDAH and VIDAH create a very effec... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467872 Wed, 10 Jun 2009 02:31:38 +0100 2467872 http://www.medworm.com/index.php?rid=2467871&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2007%2F053521.abs.html Interactions between sinefungin and copper(II) ions were investigated. Stoichiometry and stability constants of the metal-free system and two mononuclear complexes present in solution were determined on the basis of potentiometric data analysis. The results were compared to the Cu(II)-ornithine system due to structural similarities between both molecules. Combined spectroscopic and theoretical studies allowed for determination of coordination pattern for the Cu(II)-sinefungin complexes. At acidic pH, copper is bound in “glycine-like” coordination mode, identical with that of ornithine. This involves α-amino group and the carboxyl oxygen. At higher pH, a “bis-complex” is formed by two sinefungin molecules. The second ligand binds in equatorial position d... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467871 Wed, 10 Jun 2009 02:31:38 +0100 2467871 http://www.medworm.com/index.php?rid=2467870&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2007%2F096536.abs.html Solution equilibrium studies on Fe(III) complexes formed with imidazole-4-carbohydroxamic acid (Im-4-Cha), N-Me-imidazole-4-carbohydroxamic acid (N-Me-Im-4-Cha), imidazole-4-acetohydroxamic acid (Im-4-Aha), and histidinehydroxamic acid (Hisha) have been performed by using pH-potentiometry, UV-visible spectrophotometry, EPR, ESI-MS, and H1-NMR methods. All of the obtained results demonstrate that the imidazole moiety is able to play an important role very often in the interaction with Fe(III), even if this metal ion prefers the hydroxamate chelates very much. If the imidazole moiety is in α-position to the hydroxamic one (Im-4-Cha and N-Me-Im-4-Cha) its coordination to the metal ion is indicated unambiguously by our results. Interestingly, parallel formation of (Nimidazole, Ohydrox... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467870 Wed, 10 Jun 2009 02:31:38 +0100 2467870 http://www.medworm.com/index.php?rid=2467869&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2007%2F051567.abs.html The 12: 1 reaction of urea (U) with CoI2 in EtOH yielded the “clathrate-coordination” compound [CoU6]I2·4U (1). The complex crystallizes in the monoclinic space group P21/c. The lattice constants are a = 9.844(4), b = 7.268(3), c = 24.12(1) Å, and β=98.12(1)∘. The crystal structure determination demonstrates the existence of octahedral [CoU6]2+ cations, I- counterions, and two different types (two U1 and two U2) of hydrogen-bonded, lattice urea molecules. The [CoU6]2+ cations and the U1 lattice molecules form two-dimensional hydrogen-bonded layers which are parallel to the ab plane. The I- anions are placed above and below each layer, and are hydrogen bonded both to U1 molecules and [CoU6]2+ cations. Each U2 molecule is connected to a [CoU6]2+ cati... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467869 Wed, 10 Jun 2009 02:31:38 +0100 2467869 http://www.medworm.com/index.php?rid=2467868&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F479897.html A new series of Zn2+, Cu2+, Ni2+, and Co2+ complexes of N1-methyl-2-(1H-1,2,3-benzotriazol-1-yl)-3-oxobutanethioamide (MBOBT), HL, has been synthesized and characterized by different spectral and magnetic measurements and elemental analysis. IR spectral data indicates that (MBOBT) exists only in the thione form in the solid state while 13C NMR spectrum indicates its existence in thione and thiole tautomeric forms. The IR spectra of all complexes indicate that (MBOBT) acts as a monobasic bidentate ligand coordinating to the metal(II) ions via the keto-oxygen and thiolato-sulphur atoms. The electronic spectral studies showed that (MBOBT) bonded to all metal ions through sulphur and nitrogen atoms based on the positions and intensity of their charge transfer bands. Furthermore, the spectra... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467868 Wed, 10 Jun 2009 02:31:38 +0100 2467868 http://www.medworm.com/index.php?rid=2467867&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F294756.html The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467867 Wed, 10 Jun 2009 02:31:38 +0100 2467867 http://www.medworm.com/index.php?rid=2467866&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F654137.html A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)3Sn(TBA)⋅H2O] (1) has been synthesized and characterized by elemental analysis and 119Sn-NMR and FT-IR spectroscopic techniques. The crystal structure of complex 1 has been determined by single crystal X-ray diffraction analysis at 120(2) K. The geometry around Sn(IV) is trigonal bipyramidal. Three n-butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center. The geometry is completed with one oxygen from a water molecule. Compound 1 exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis. In addition, the inhi... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467866 Wed, 10 Jun 2009 02:31:38 +0100 2467866 http://www.medworm.com/index.php?rid=2467865&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F257038.html The N- and C-terminal blocked hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide (LAHYNK) representing the 80–85 fragment of histone H2B was synthesized and its interactions with Cu(II) and Ni(II) ions were studied by potentiometric, UV-Vis, CD, EPR, and NMR spectroscopic techniques in solution. Our data reveal that the imidazole N(3) nitrogen atom is the primary ligating group for both metal ions. Sequential amide groups deprotonation and subsequent coordination to metal ions indicated an {Nimidazole,3Namide} coordination mode above pH∼9, in all cases. In the case of Cu(II)-peptide system, the almost exclusive formation of the predominant species CuL in neutral media accounting for almost 98% of the total metal ion concentration at pH 7.3 strongly indicates that at physiologica... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467865 Wed, 10 Jun 2009 02:31:38 +0100 2467865 http://www.medworm.com/index.php?rid=2467864&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F420578.html In this study we analyzed blood and urine samples from shipyard industry welders being exposed to different levels of Cr(VI) over a period of five months in order to assay in vivo the relation of ApoJ/CLU serum levels with Cr(VI). Our findings confirmed the previously reported in vitro data since reduction of Cr levels, after a worksite intervention, associated with lower levels of ApoJ/CLU serum levels. We concluded that the human ApoJ/CLU gene is responsive to the acute in vivo oxidative stress induced by heavy metals such as hexavalent chromium. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467864 Wed, 10 Jun 2009 02:31:38 +0100 2467864 http://www.medworm.com/index.php?rid=2467863&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F469062.html Molecular dynamics simulation of the interaction between the Tenebrio molitor alpha-amylase and its inhibitor at different proportion of crystal water was carried out with OPLS force field by hyperchem 7.5 software. In the correlative study, the optimal temperature of wheat monomeric and dimeric protein inhibitors was from 273 K to 318 K. The the average temperature of experimentation is 289 K. (1) The optimal temperature of interaction between alpha-amylase and its inhibitors was 280 K without crystal water that was close to the results of experimentation. The forming of enzyme-water and inhibitor-water was easy, but incorporating third monomer was impossible. (2) Having analyzed the potential energy data, the optimal temperature of interaction energy between a... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467863 Wed, 10 Jun 2009 02:31:38 +0100 2467863 http://www.medworm.com/index.php?rid=2467862&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F367471.html The antineoplastic potential of a stable monomeric Au(II) complex with hematoporphyrin IX (Hp), namely [Au(II)Hp-2H.(H2O)2], was investigated in a panel of tumor cell lines. The complex exhibits strong cytotoxicity, whereby the leukaemia- and lymphoma-derived cell lines are more sensitive, with IC50 values comparable to those of the reference anticancer drug cisplatin. In contrast, the solid tumor models are more sensitive to the platinum drug. A comparative assessment of both agents against the human kidney cell line 293T has shown that [Au(II)Hp-2H.(H2O)2] is less cytotoxic. The gold complex induces oligonucleosomal DNA fragmentation in tumour cells following 24-hour treatment and hence its cytotoxic effect is at least partly mediated by induction of apoptotic cell death. A prominent int... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467862 Wed, 10 Jun 2009 02:31:38 +0100 2467862 http://www.medworm.com/index.php?rid=2467861&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F539082.html The trivalent arsenic glutathione complexes arsenic triglutathione, methylarsonous diglutathione, and dimethylarsinous glutathione are key intermediates in the mammalian metabolism of arsenite and possibly represent the arsenic species that are transported from the liver to the kidney for urinary excretion. Despite this, the comparative stability of the arsenic-sulfur bonds in these complexes has not been investigated under physiological conditions resembling hepatocyte cytosol. Using size-exclusion chromatography and a glutathione-containing phosphate buffered saline mobile phase (5 or 10 mM glutathione, pH 7.4) in conjunction with an arsenic-specific detector, we chromatographed arsenite, monomethylars... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467861 Wed, 10 Jun 2009 02:31:38 +0100 2467861 http://www.medworm.com/index.php?rid=2467860&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F983725.html A sequence of stages in the syntheses of isomeric bisamino acid complexes of Pt(II) with β-aminopropionic acid (β-alanine = β-AlaH) has been studied by the P195t NMR spectroscopy. The techniques have been developed of the synthesis of the cis- and trans-bischelates of Pt(II) and Pd(II) with β-alanine as well as of the halide complexes of trans-[M(β-AlaH)2Cl2] (M = Pt, Pd) and trans-K2[Pt(β-Ala)2I2] types. The NMR spectroscopy and IR spectroscopy (in the nuclei of P195t,C13,H1) and X-ray diffraction analysis have been used to examine the structures of the synthesized compounds. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467860 Wed, 10 Jun 2009 02:31:38 +0100 2467860 http://www.medworm.com/index.php?rid=2467859&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F576297.html Class B β-lactamases or metallo-β-lactamases (MBLs) require zinc ions to catalyse the hydrolysis of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, and cephamycins. There are no clinically useful inhibitors against MBLs which are responsible for the resistance of some bacteria to antibiotics. There are two metal-ion binding sites that have different zinc ligands but the exact roles of the metal-ion remain controversial, and distinguishing between their relative importance is complex. The metal-ion can act as a Lewis acid by co-ordination to the β-lactam carbonyl oxygen to facilitate nucleophilic attack and stabilise the negative charge developed on this oxygen in the tetrahedral intermediate anion. The metal-ion also lowers the pKa of the ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467859 Wed, 10 Jun 2009 02:31:38 +0100 2467859 http://www.medworm.com/index.php?rid=2467858&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F624583.html Our study of the complexation of 3,4-dihydroxy-phenyl-propenoic acid by chromium(III) could give information on the way that this metal ion is available to plants. The reaction between chromium(III) and 3,4-dihydroxy-phenyl-propenoic acid in weak acidic aqueous solutions has been shown to take place by at least three stages. The first stage corresponds to substitution (Id mechanism) of water molecule from the Cr(H2O)5OH2+ coordination sphere by a ligand molecule. A very rapid protonation equilibrium, which follows, favors the aqua species. The second and the third stages are chromium(III) and ligand concentration independent and are attributed to isomerisation and chelation processes. The corresponding activation parameters are ΔH2(obs)≠ = 28.6 ± 2.9 kJ mol&#x22... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467858 Wed, 10 Jun 2009 02:31:38 +0100 2467858 http://www.medworm.com/index.php?rid=2467857&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F253971.html Interactions between aspartic acid (Asp) and cytidine-5-monophosphate (CMP) in metal-free systems as well as the coordination of Cu(II) ions with the above ligands were studied. The composition and overall stability constants of the species formed in those systems were determined by the potentiometric method, and the interaction centres in the ligands were identified by the spectral methods UV-Vis, EPR, NMR, and IR. In metal-free systems, the formation of adducts, in which each ligand has both positive and negative reaction centres, was established. The main reaction centres in Asp are the oxygen atoms of carboxyl groups and the nitrogen atom of the amine group, while the main reaction centre in CMP at low pH is the N(3) atom. With increasing pH, the efficiency of the phosphate group of th... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467857 Wed, 10 Jun 2009 02:31:38 +0100 2467857 http://www.medworm.com/index.php?rid=2467856&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F762029.html The biomimetic catalytic oxidations of the dinuclear and trinuclear copper(II) complexes versus two catechols, namely, D-(+)-catechin and L-(−)-epicatechin to give the corresponding quinones are reported. The unstable quinones were trapped by the nucleophilic reagent, 3-methyl-2-benzothiazolinone hydrazone (MBTH), and have been calculated the molar absorptivities of the different quinones. The catalytic efficiency is moderate, as inferred by kinetic constants, but the complexes exhibit significant enantio-differentiating ability towards the catechols, albeit for the dinuclear complexes, this enantio-differentiating ability is lower. In all cases, the preferred enantiomeric substrate is D-(+)-catechin to respect the other catechol, because of the spatial disposition of this s... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467856 Wed, 10 Jun 2009 02:31:38 +0100 2467856 http://www.medworm.com/index.php?rid=2467855&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F436458.html Formation of silver citrate/citric acid complexed solutions was investigated. Although, silver citrate is minimally soluble in water, it can successfully be dissolved in citric acid solutions. The maximum concentration of Ag(I) in solution is estimated at 23 to 25 g/L if the concentration of citric acid is at least 4 mol/L or higher. The dissolution of silver citrate in citric acid solutions was attributed to the formation of silver citrate complexes of a general formula [Ag3(C6H5O7)n+1]3n−. The silver citrate/citric acid solutions, containing more than about 13 g/L Ag+ ion, have exhibited a decrease in Ag(I) concentration in solution over time, due to crystallization. The crystallization product was attributed to the formation of [Ag3C6H5O7]x⋅nH2O. Impor... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467855 Wed, 10 Jun 2009 02:31:38 +0100 2467855 http://www.medworm.com/index.php?rid=2467854&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F706240.html In order to investigate the behavior of rare earth elements (REEs) and uranium (U) in marine organism, the concentrations of REEs and U in some brown algae samples taken on the coast of Niigata Prefecture were determined. In addition, laboratory model experiment to uptake these elements using living and dried algae (Undaria pinnatifida and Sargassum hemiphyllum) was also carried out to survey the uptake and bioaccumulation mechanism of REEs and U in algae. Consequently, the following matters have been mainly clarified. (1) The order of the concentration of REEs for each organ in Sargassum hemiphyllum is “main branch” > “leaf” > “vesicle,” however for U, the order is “leaf” > “vesicle” > “main branch.” (... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467854 Wed, 10 Jun 2009 02:31:38 +0100 2467854 http://www.medworm.com/index.php?rid=2467853&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F690952.html The palladium(II) bis-chelate Pd (L1−3)2 and platinum(II) tetranuclear Pt4(L4)4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (1H,13C) spectroscopy. The complex Pd(L2)2 [HL2=m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a trans arrangement, while the complex Pt4(L4)4 [HL4=4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and thei... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467853 Wed, 10 Jun 2009 02:31:38 +0100 2467853 http://www.medworm.com/index.php?rid=2467852&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F501021.html (6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR, and UV-Visible spectroscopy. All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements. The elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation. The molar conductance measurements reveal the presence of 1:1 electrolytic nature complexes. These new complexes showed ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467852 Wed, 10 Jun 2009 02:31:38 +0100 2467852 http://www.medworm.com/index.php?rid=2467851&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F547915.html In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II). These complexes have been studied by means of EPR spectroscopy and magnetic susceptibility measurements. From the obtained results, a preliminary complexation mode of the ligand is proposed. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467851 Wed, 10 Jun 2009 02:31:38 +0100 2467851 http://www.medworm.com/index.php?rid=2467850&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F212461.html The interactions between chromium(III) and 3,4-dihydroxybenzoic acid (3,4-DHBA) were studied resulting in the formation of oxygen-bonded complexes upon substitution of water molecules in the chromium(III) coordination sphere. The experimental results show that the reaction takes place in at least three stages, involving various intermediates. The first stage was found to be linearly dependent on ligand concentration k1(obs)_=k0+k1(obs)[3,4-DHBA], and the corresponding activation parameters were calculated as follows: ΔH1(obs)≠=51.2±11.5 kJ mol−1, ΔS1(obs)≠=−97.3±28.9 J mol−1 K−1 (composite activation parameters) . The second and third stages, which are kinetically indistinguishable... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467850 Wed, 10 Jun 2009 02:31:38 +0100 2467850 http://www.medworm.com/index.php?rid=2467849&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2008%2F647873.html The new complexes [M2O5L2(H2O)2]⋅H2O (M=Mo,1;M=W,2), [RuL2(H2O)2]⋅H2O  (3), [ML3]⋅xH2O (M=Rh,x=2,4;M=Ir,x=1,5), [RhL2(PPh3)2](ClO4)⋅2H2O  (6), [PdL2]⋅2H2O  (7), [PdL(phen)]Cl⋅H2O  (8), [Re⁡OL2(PPh3)]Cl  (9) and [UO2L2]  (10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand field, NMR, mass) methods. The ligand L− is in its thione form and behaves as a bidentate chelate with the deprotonated (hydroxyl) oxygen and the nitrogen of one amino gro... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467849 Wed, 10 Jun 2009 02:31:38 +0100 2467849 http://www.medworm.com/index.php?rid=2467848&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F542979.html Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, H1, S119n-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467848 Wed, 10 Jun 2009 02:31:38 +0100 2467848 http://www.medworm.com/index.php?rid=2467847&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F851316.html A series of metal complexes of Zn(II) and Hg(II) having the general composition [M(L)2]X2 [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = Cl−, NO3   − and 1/2SO4   2−] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties. (Source: Bioinorganic Chemistry and ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467847 Wed, 10 Jun 2009 02:31:38 +0100 2467847 http://www.medworm.com/index.php?rid=2467846&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fbca%2F2009%2F908625.html Five new organogermanium sesquioxides have been synthesized and characterized by elemental analysis and IR spectra. All the compounds were tested for antitumor activities against KB, HCT, and Bel cells in vitro. Compound 5 (γ-thiocarbamido propyl germanium sesquioxide) showed excellent antitumor activity, and its inhibition yield to KB, HCT, and Bel cells was 92.9%, 84.9%, and 70.9%, respectively. A rapid method was described for the labeling compound 5 with T99mc, and the optimum labeling conditions were investigated. The labeling yield is above 90% in pH 7.0, 20∘C, reaction time greater than 10 minutes, 1 mg of compound 5, and 0.075∼0.1 mg of SnCl2. The biodistribution of T99mc labeled compound 5 in nude mice bearing human colonic xenogr... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2467846 Wed, 10 Jun 2009 02:31:38 +0100 2467846 http://www.medworm.com/index.php?rid=2455849&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2009%2F908625 Five new organogermanium sesquioxides have been synthesized and characterized by elemental analysis and IR spectra. All the compounds were tested for antitumor activities against KB, HCT, and Bel cells in vitro. Compound 5 (γ-thiocarbamido propyl germanium sesquioxide) showed excellent antitumor activity, and its inhibition yield to KB, HCT, and Bel cells was 92.9%, 84.9%, and 70.9%, respectively. A rapid method was described for the labeling compound 5 with T99mc, and the optimum labeling conditions were investigated. The labeling yield is above 90% in pH 7.0, 20∘C, reaction time greater than 10 minutes, 1 mg of compound 5, and 0.075∼0.1 mg of SnCl2. The biodistribution of T99mc labeled compound 5 in nude mice bearing human colonic xenogr... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2455849 Fri, 05 Jun 2009 22:36:47 +0100 2455849 http://www.medworm.com/index.php?rid=2379972&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2009%2F851316 A series of metal complexes of Zn(II) and Hg(II) having the general composition [M(L)2]X2 [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = Cl−, NO3   − and 1/2SO4   2−] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties. (Source: Bioinorganic Chemistry and ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2379972 Thu, 30 Apr 2009 18:56:51 +0100 2379972 http://www.medworm.com/index.php?rid=2339889&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2009%2F542979 Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, H1, S119n-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2339889 Sat, 18 Apr 2009 18:02:52 +0100 2339889 http://www.medworm.com/index.php?rid=2295735&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F647873 The new complexes [M2O5L2(H2O)2]⋅H2O (M=Mo,1;M=W,2), [RuL2(H2O)2]⋅H2O  (3), [ML3]⋅xH2O (M=Rh,x=2,4;M=Ir,x=1,5), [RhL2(PPh3)2](ClO4)⋅2H2O  (6), [PdL2]⋅2H2O  (7), [PdL(phen)]Cl⋅H2O  (8), [Re⁡OL2(PPh3)]Cl  (9) and [UO2L2]  (10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand field, NMR, mass) methods. The ligand L− is in its thione form and behaves as a bidentate chelate with the deprotonated (hydroxyl) oxygen and the nitrogen of one amino gro... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2295735 Sun, 29 Mar 2009 03:02:08 +0100 2295735 http://www.medworm.com/index.php?rid=2157450&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F212461 The interactions between chromium(III) and 3,4-dihydroxybenzoic acid (3,4-DHBA) were studied resulting in the formation of oxygen-bonded complexes upon substitution of water molecules in the chromium(III) coordination sphere. The experimental results show that the reaction takes place in at least three stages, involving various intermediates. The first stage was found to be linearly dependent on ligand concentration k1(obs)_=k0+k1(obs)[3,4-DHBA], and the corresponding activation parameters were calculated as follows: ΔH1(obs)≠=51.2±11.5 kJ mol−1, ΔS1(obs)≠=−97.3±28.9 J mol−1 K−1 (composite activation parameters) . The second and third stages, which are kinetically indistinguishable... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2157450 Wed, 04 Feb 2009 13:58:43 +0100 2157450 http://www.medworm.com/index.php?rid=2153358&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F547915 In this report, we present the complexation reactions of 3-ethoxycarbonyl tetronic acids with acetates and chlorides of Cu(II) and Co(II). These complexes have been studied by means of EPR spectroscopy and magnetic susceptibility measurements. From the obtained results, a preliminary complexation mode of the ligand is proposed. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2153358 Tue, 03 Feb 2009 13:20:02 +0100 2153358 http://www.medworm.com/index.php?rid=2142071&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F690952 The palladium(II) bis-chelate Pd (L1−3)2 and platinum (II) tetranuclear Pt4(L4)4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (1H,13C) spectroscopy. The complex Pd(L2)2 [HL2=m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a trans arrangement, while the complex Pt4(L4)4 [HL4=4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and the... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2142071 Thu, 29 Jan 2009 16:21:58 +0100 2142071 http://www.medworm.com/index.php?rid=2132714&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F501021 (6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR, and UV-Visible spectroscopy. All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements. The elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation. The molar conductance measurements reveal the presence of 1:1 electrolytic nature complexes. These new complexes showed ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2132714 Mon, 26 Jan 2009 12:11:39 +0100 2132714 http://www.medworm.com/index.php?rid=2087656&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F690952 The palladium (II) bis-chelate Pd (L1−3)2 and platinum (II) tetranuclear Pt4(L4)4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (1H,13C) spectroscopy. The complex Pd(L2)2 [HL2=m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a transarrangement, while the complex Pt4(L4)4 [HL4=4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and the... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=2087656 Thu, 08 Jan 2009 12:24:21 +0100 2087656 http://www.medworm.com/index.php?rid=1999622&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F706240 In order to investigate the behavior of rare earth elements (REEs) and uranium (U) in marine organism, the concentrations of REEs and U in some brown algae samples taken on the coast of Niigata Prefecture were determined. In addition, laboratory model experiment to uptake these elements using living and dried algae (Undaria pinnatifida and Sargassum hemiphyllum) was also carried out to survey the uptake and bioaccumulation mechanism of REEs and U in algae. Consequently, the following matters have been mainly clarified. (1) The order of the concentration of REEs for each organ in Sargassum hemiphyllum is “main branch” > “leaf” > “vesicle,” however for U, the order is “leaf” > “vesicle” > “main branch.” (... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1999622 Mon, 01 Dec 2008 12:53:56 +0100 1999622 http://www.medworm.com/index.php?rid=1992560&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F436458 Formation of silver citrate/citric acid complexed solutions was investigated. Although, silver citrate is minimally soluble in water, it can successfully be dissolved in citric acid solutions. The maximum concentration of Ag(I) in solution is estimated at 23 to 25 g/L if the concentration of citric acid is at least 4 mol/L or higher. The dissolution of silver citrate in citric acid solutions was attributed to the formation of silver citrate complexes of a general formula [Ag3(C6H5O7)n+1]3n−. The silver citrate/citric acid solutions, containing more than about 13 g/L Ag+ ion, have exhibited a decrease in Ag(I) concentration in solution over time, due to crystallization. The crystallization product was attributed to the formation of [Ag3C6H5O7]x⋅nH2O. Impor... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1992560 Thu, 27 Nov 2008 15:12:26 +0100 1992560 http://www.medworm.com/index.php?rid=1816411&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F762029 The biomimetic catalytic oxidations of the dinuclear and trinuclear copper(II) complexes versus two catechols, namely, D-(+)-catechin and L-(−)-epicatechin to give the corresponding quinones are reported. The unstable quinones were trapped by the nucleophilic reagent, 3-methyl-2-benzothiazolinone hydrazone (MBTH), and have been calculated the molar absorptivities of the different quinones. The catalytic efficiency is moderate, as inferred by kinetic constants, but the complexes exhibit significant enantio-differentiating ability towards the catechols, albeit for the dinuclear complexes, this enantio-differentiating ability is lower. In all cases, the preferred enantiomeric substrate is D-(+)-catechin to respect the other catechol, because of the spatial disposition of this s... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1816411 Tue, 23 Sep 2008 18:24:54 +0100 1816411 http://www.medworm.com/index.php?rid=1665290&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F253971 Interactions between aspartic acid (Asp) and cytidine-5-monophosphate (CMP) in metal-free systems as well as the coordination of Cu(II) ions with the above ligands were studied. The composition and overall stability constants of the species formed in those systems were determined by the potentiometric method, and the interaction centres in the ligands were identified by the spectral methods UV-Vis, EPR, NMR, and IR. In metal-free systems, the formation of adducts, in which each ligand has both positive and negative reaction centres, was established. The main reaction centres in Asp are the oxygen atoms of carboxyl groups and the nitrogen atom of the amine group, while the main reaction centre in CMP at low pH is the N(3) atom. With increasing pH, the efficiency of the phosphate group of th... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1665290 Wed, 30 Jul 2008 15:22:45 +0100 1665290 http://www.medworm.com/index.php?rid=1658348&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F624583 Our study of the complexation of 3,4-dihydroxy-phenyl-propenoic acid by chromium(III) could give information on the way that this metal ion is available to plants. The reaction between chromium(III) and 3,4-dihydroxy-phenyl-propenoic acid in weak acidic aqueous solutions has been shown to take place by at least three stages. The first stage corresponds to substitution (Id mechanism) of water molecule from the Cr(H2O)5OH2+ coordination sphere by a ligand molecule. A very rapid protonation equilibrium, which follows, favors the aqua species. The second and the third stages are chromium(III) and ligand concentration independent and are attributed to isomerisation and chelation processes. The corresponding activation parameters are ΔH2(obs)≠ = 28.6 ± 2.9 kJ mol&#x22... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1658348 Mon, 28 Jul 2008 12:56:23 +0100 1658348 http://www.medworm.com/index.php?rid=1492735&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F576297 Class B β-lactamases or metallo-β-lactamases (MBLs) require zinc ions to catalyse the hydrolysis of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, and cephamycins. There are no clinically useful inhibitors against MBLs which are responsible for the resistance of some bacteria to antibiotics. There are two metal-ion binding sites that have different zinc ligands but the exact roles of the metal-ion remain controversial, and distinguishing between their relative importance is complex. The metal-ion can act as a Lewis acid by co-ordination to the β-lactam carbonyl oxygen to facilitate nucleophilic attack and stabilise the negative charge developed on this oxygen in the tetrahedral intermediate anion. The metal-ion also lowers the pKa of the ... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1492735 Wed, 04 Jun 2008 17:45:00 +0100 1492735 http://www.medworm.com/index.php?rid=1489874&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F92595 The progress of the research work of the author and his colleagues on the field of CL-emission generated by pyrogallol oxidation and further application for the direct determination of periodate and indirect or direct determination of other compounds through flow-injection manifold/CL-detection set up is described. The instrumentation used for these studies was a simple flow-injection manifold that provides good reproducibility, coupled to a red sensitive photomultiplier that gives sensitive CL-detection. In addition, recent reports on studies and analytical methods based on CL-emission generated by periodate oxidation by other authors are included. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489874 Tue, 03 Jun 2008 22:25:23 +0100 1489874 http://www.medworm.com/index.php?rid=1489873&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F69263 A novel method for the preparation of hitherto unknown symmetrical bis(2-halo-3-pyridyl) dichalcogenides (E = S, Se and Te) by the oxidation of intermediate 2-halo-3-pyridyl chalcogenolate, prepared by lithiation of 2-halo pyridines using lithium diisopropylamine is being reported. All the newly synthesized compounds have been characterized through elemental analysis employing various spectroscopic techniques, namely, NMR (H1, C13, S77e), infrared, mass spectrometry, and X-ray crystal structures in representative cases. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489873 Tue, 03 Jun 2008 22:25:23 +0100 1489873 http://www.medworm.com/index.php?rid=1489872&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F65815 This review discusses in detail “calixarenes” since their discovery as by-products of the phenol formaldehyde bakelites till the present scenario wherein calixarene has assumed a new dimension in the field of supramolecular chemistry. Extensive literature exists for calixarenes; but herein we have tried to concentrate on the different lower-rim modified calixarenes with their potential applications. An attempt has also been made to critically evaluate the synthesis procedures for different lower-rim substituted calixarenes. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489872 Tue, 03 Jun 2008 22:25:23 +0100 1489872 http://www.medworm.com/index.php?rid=1489871&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F17416 The 3 centre-4 electrons (3c-4e) and the donor/acceptor or charge-transfer models for the description of the chemical bond in linear three-body systems, such as I3− and related electron-rich (22 shell electrons) systems, are comparatively discussed on the grounds of structural data from a search of the Cambridge Structural Database (CSD). Both models account for a total bond order of 1 in these systems, and while the former fits better symmetric systems, the latter describes better strongly asymmetric situations. The 3c-4e MO scheme shows that any linear system formed by three aligned closed-shell species (24 shell electrons overall) has reason to exist provided that two electrons are removed from it to afford a 22 shell electrons three-body system: all combinations o... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489871 Tue, 03 Jun 2008 22:25:23 +0100 1489871 http://www.medworm.com/index.php?rid=1489870&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F23286 This paper is a brief review of the detailed mechanism of action of thiamine enzymes, based on metal complexes of bivalent transition and post-transition metals of model compounds, thiamine derivatives, synthesized and characterized with spectroscopic techniques and X-ray crystal structure determinations. It is proposed that the enzymatic reaction is initiated with a V conformation of thiamine pyrophosphate, imposed by the enzymic environment. Thiamine pyrophosphate is linked with the proteinic substrate through its pyrophosphate oxygens. In the course of the reaction, the formation of the “active aldehyde” intermediate imposes the S conformation to thiamine, while a bivalent metal ion may be linked through the N1' site of the molecule, at this stage. Finally, the immobiliz... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489870 Tue, 03 Jun 2008 22:25:23 +0100 1489870 http://www.medworm.com/index.php?rid=1489869&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F46393 Trends in the properties of normal valent and multivalent halogen-oxygen bonding are examined for the isomers of the halogen polyoxide families of the types (YXO2) and (YXO3), Y=Cl, Br, I, H, CH3, X=Cl, Br, I. A qualitative model is formulated on the relationship between the X-O bond distance variations, the ionic character of the bonding, and the degree of halogen valence. The relative stability and enthalpy of formation of each species are also suggested to correlate with the ionic nature of the X-O bonding and the electrostatic character of the Y, YO fragments. In the model presented, halogen hypervalence is interpreted to be the result of partial p→d promotion of lone-pair valence electrons followed by the formation of two, four, or six additional pd hybrid bonds around the halo... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489869 Tue, 03 Jun 2008 22:25:23 +0100 1489869 http://www.medworm.com/index.php?rid=1489868&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F87918 The reactions of (η5−C5H5)2MCl2 (M = Ti, Zr, or Hf) with mercaptoazoles (LH2), namely, bis(mercaptotriazoles), bis(mercap-tooxadiazoles), and bis(mercaptothiadiazoles) in 2 : 1 molar ratio, respectively, have been studied in dry tetrahydrofuran in the presence of n-butylamine and the binuclear complexes of the type [{(η−C5H5)2M}2(L)] (M = Ti/Zr/Hf) are obtained. Tentative structural conclusions are drawn for the reaction products based upon elemental analysis, electrical conductance, magnetic moment, and spectral data (UV-Vis, IR, H1 NMR, and C13 NMR). FAB-mass spectra of few complexes of each series were also carried out to confirm the binuclear structures. Studies were conducted to assess the growth-inhibiting potential of the complexes synthesiz... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489868 Tue, 03 Jun 2008 22:25:23 +0100 1489868 http://www.medworm.com/index.php?rid=1489867&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F54562 In this paper, three complexes of type [Co(en)2PIP]3+(PIP=2-phenylimidazo[4,5-f][1,10,] phenanthroline)(1), [Co(en)2IP]3+ (IP=imidazo[4,5-f][1,10,] phenanthroline)(2), and [Co(en)2phen-dione]3+(1,10 phenanthroline 5,6,dione)(3) have been synthesized and characterized by UV/VIS, IR, 1H NMR spectral methods. Absorption spectroscopy, emission spectroscopy, viscosity measurements, and DNA melting techniques have been used for investigating the binding of these two complexes with calf thymus DNA, and photocleavage studies were used for investigating these binding of these complexes with plasmid DNA. The spectroscopic studies together with viscosity measurements and DNA melting studies support that complexes 1 and 2 bind to CT DNA(=calf thymus DNA) by intercalation mode via IP or PIP into the ba... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489867 Tue, 03 Jun 2008 22:25:23 +0100 1489867 http://www.medworm.com/index.php?rid=1489866&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F28508 Reactions of 2,2'-pyridil (pyCOCOpy) with CuCl2⋅2H2O and CuBr2 in EtOH yielded the mononuclear complex [Cu(pyCOOEt)2Cl2]⋅H2O (1) and the one-dimensional, mixed-valence complex [Cu2ICuII(pyCOOEt)2Br4]n (2), respectively. Both complexes crystallize in the triclinic space group P 1¯. The lattice constants are a=8.382(2), b=9.778(2), c=7.814(2), α=101.17(1), β=114.55(1), γ=94.14(1)∘ for 1 and a=8.738(1), b=9.375(2), c=7.966(1), α=79.09(1), β=64.25(1), γ=81.78(1)∘ for 2. 2,2'-pyridil undergoes a metal-assisted alcoholysis and oxidation leading to decomposition and yielding the ethyl picolinate (pyCOOEt) ligand. The autoredox process associated with the reduction of copper(II) to copper(I) in the case of c... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489866 Tue, 03 Jun 2008 22:25:23 +0100 1489866 http://www.medworm.com/index.php?rid=1489865&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F92145 A number of trimethylsiloxyalkyl and trialkylsilylalkyl thiazole derivatives have been evaluated for their anti-inflammatory activity, lipoxygenase inhibiting properties, and cytotoxicity. The investigated compounds have been found to protect in vivo against carrageenin-induced edema, especially 3-(4-trimethylsiloxypiperidin-1-yl)-N-(thiazol-2-yl)-propionamide (21) and 2-amino-3-(γ-trimethylsilylpropyl)thiazolium iodide (22), which exhibited good anti-inflammatory activity: 57.2% CPE inhibition in dose of 0.2 mmol/kg for compound 21 and 55.0% in dose of 0.01 mmol/kg for compound 22. All the compounds tested inhibited soybean lipoxygenase activity. 2-(4-Trimethylsilyloxypiperidin-1-yl)-N-[4-(p-methoxyphenyl)-thiazol-2-yl]-acetamide (19) was the most potent... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489865 Tue, 03 Jun 2008 22:25:23 +0100 1489865 http://www.medworm.com/index.php?rid=1489864&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F98732 Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and H1, C13, and P195t NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)(μ-Cl)]2·2DMF was determined by X-ray diffraction. Two 9-acridine molecules in the imine form bind symmetrically to the metal ions in a bidentate fashion through the imine nitrogen atom and the C(1) atom of the aminoacridine closing a new five-membered ring. By reaction with phosphine or pyridine, the Cl bridges broke and compounds with general formulae [Pd(9AA)Cl(L)] (where L=PPh3 or py) were formed. A mononuclear complex of platinum of formulae [Pt(9AA)Cl(DMSO)] was also obtained by direct reaction... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489864 Tue, 03 Jun 2008 22:25:23 +0100 1489864 http://www.medworm.com/index.php?rid=1489863&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F54232 The unfolding process of the blue copper protein rusticyanin has been studied from the structural and the thermodynamic points of view at two pH values (pH 2.5 and 7.0). When Rc unfolds, copper ion remains bound to the polypeptide chain. Nuclear magnetic resonance data suggest that three of the copper ligands in the folded state are bound to the metal ion in the unfolded form, while the other native ligand is detached. These structural changes are reflected in the redox potentials of the protein in both folded and unfolded forms. The affinities of the copper ion in both redox states have been also determined at the two specified pH values. The results indicate that the presence of two histidine ligands in the folded protein can compensate the change in the net charge that the copper ion re... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489863 Tue, 03 Jun 2008 22:25:23 +0100 1489863 http://www.medworm.com/index.php?rid=1489862&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F43424 Two copper(II)-ACC complexes were prepared and characterized: [Cu(bpy)(ACC)(H2O)]⋅CO4 (1) and [Cu(ACC)2]3⋅4H2O (2). Their crystallographic structures are described and analyzed. Spectroscopic characterizations (UV-visible and EPR) confirm that the structure is maintained in solution. These complexes are able to produce ethylene in the presence of hydrogen peroxide in an “ACC Oxidase-like” reaction in water and in methanol. The conversion of ACC into ethylene depends on the amount of base, and, in methanol, 3 equivalents of NaOH are needed for optimum activity. The base is proposed to play a role in H2O2 deprotonation. The presence of an exogenic ligand (bpy) is important for the reactivity and may stabilize a reaction intermediate. Indeed, a brown intermediate w... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489862 Tue, 03 Jun 2008 22:25:23 +0100 1489862 http://www.medworm.com/index.php?rid=1489861&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F42587 The synthesis and characterization of title complexes of the ligand Quinolino[3,2-b]benzodiazepine (QBD) and Quinolino[3,2-b]benzoxazepine (QBO) are reported. The complexes have been characterized by elemental analysis, molar conductance, magnetic studies, IR, H1 NMR, and UV-visible studies. They have the stoichiometry [ML2C12], where M=Co(II)/Ni(II), L=QBD/QBO, and [MLC12], where M=Zn(II)/Cd(II), L=QBD/QBO. The antibacterial and antifungal activity of the metal complexes has been investigated. The complexes were found to have higher antimicrobial activity than the parent ligand. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489861 Tue, 03 Jun 2008 22:25:23 +0100 1489861 http://www.medworm.com/index.php?rid=1489860&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F91078 The interaction of drugs with DNA is an important aspect in pharmacology. In recent years, many important technological advances have been made to develop new techniques to monitor biorecognition and biointeraction on solid devices. The interaction between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical properties of nucleobases. The propensity of a given compound to interact with DNA is measured as a function of the decrease of guanine oxidation signal on a DNA electrochemical biosensor. Covalent binding at N7 of guanine, electrostatic interactions, and intercalation are the events that this kind of biosensor can detect. In this context, the interaction between a panel of antitumoral Pt-, Ru-, and Ti-based metallodrugs with DNA... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489860 Tue, 03 Jun 2008 22:25:23 +0100 1489860 http://www.medworm.com/index.php?rid=1489859&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F51483 A series of metal complexes of Cu(II) and Ni(II) having the general composition [M(L)X2] with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489859 Tue, 03 Jun 2008 22:25:23 +0100 1489859 http://www.medworm.com/index.php?rid=1489858&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F10720 The 173–195 segment corresponding to the helix 2 of the C-globular prion protein domain could be one of several “spots” of intrinsic conformational flexibility. In fact, it possesses chameleon conformational behaviour and gathers several disease-associated point mutations. We have performed spectroscopic studies on the wild-type fragment 173–195 and on its D178N mutant dissolved in trifluoroethanol to mimic the in vivo system, both in the presence and in the absence of metal cations. NMR data showed that the structure of the D178N mutant is characterized by two short helices separated by a kink, whereas the wild-type peptide is fully helical. Both peptides retained these structural organizations, as monitored by CD, in the presence of metal cations. NMR spectra were... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489858 Tue, 03 Jun 2008 22:25:23 +0100 1489858 http://www.medworm.com/index.php?rid=1489857&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F30394 Terminally protected pentapeptides with 2 histidines (Ac-HHVGD-NH2 and Ac-HVGDH-NH2) and the terminally free peptides containing both internal aspartyl and C-terminal histidyl residues (FDAH and VIDAH) have been synthesized, and copper(II) complexes studied by potentiometric, UV-Vis, CD, and EPR spectroscopic techniques in solution. Both thermodynamic and spectroscopic data reveal that side chain donor atoms of aspartyl and histidyl residues have a significant contribution to the metal binding affinity of peptide molecules. In the case of terminally protected peptides, the role of the imidazole-N donor functions is reflected in the enhanced stability of the 3N and 4N coordinated copper(II) complexes. The amino and β-carboxylate groups of FDAH and VIDAH create a very effec... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489857 Tue, 03 Jun 2008 22:25:23 +0100 1489857 http://www.medworm.com/index.php?rid=1489856&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F53521 Interactions between sinefungin and copper(II) ions were investigated. Stoichiometry and stability constants of the metal-free system and two mononuclear complexes present in solution were determined on the basis of potentiometric data analysis. The results were compared to the Cu(II)-ornithine system due to structural similarities between both molecules. Combined spectroscopic and theoretical studies allowed for determination of coordination pattern for the Cu(II)-sinefungin complexes. At acidic pH, copper is bound in “glycine-like” coordination mode, identical with that of ornithine. This involves α-amino group and the carboxyl oxygen. At higher pH, a “bis-complex” is formed by two sinefungin molecules. The second ligand binds in equatorial position d... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489856 Tue, 03 Jun 2008 22:25:23 +0100 1489856 http://www.medworm.com/index.php?rid=1489855&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F96536 Solution equilibrium studies on Fe(III) complexes formed with imidazole-4-carbohydroxamic acid (Im-4-Cha), N-Me-imidazole-4-carbohydroxamic acid (N-Me-Im-4-Cha), imidazole-4-acetohydroxamic acid (Im-4-Aha), and histidinehydroxamic acid (Hisha) have been performed by using pH-potentiometry, UV-visible spectrophotometry, EPR, ESI-MS, and H1-NMR methods. All of the obtained results demonstrate that the imidazole moiety is able to play an important role very often in the interaction with Fe(III), even if this metal ion prefers the hydroxamate chelates very much. If the imidazole moiety is in α-position to the hydroxamic one (Im-4-Cha and N-Me-Im-4-Cha) its coordination to the metal ion is indicated unambiguously by our results. Interestingly, parallel formation of (Nimidazole, Ohydrox... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489855 Tue, 03 Jun 2008 22:25:23 +0100 1489855 http://www.medworm.com/index.php?rid=1489854&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2007%2F51567 The 12 : 1 reaction of urea (U) with CoI2 in EtOH yielded the “clathrate-coordination” compound [CoU6]I2·4U (1). The complex crystallizes in the monoclinic space group P21/c. The lattice constants are a = 9.844(4), b = 7.268(3), c = 24.12(1) Å, and β=98.12(1)∘. The crystal structure determination demonstrates the existence of octahedral [CoU6]2+ cations, I- counterions, and two different types (two U1 and two U2) of hydrogen-bonded, lattice urea molecules. The [CoU6]2+ cations and the U1 lattice molecules form two-dimensional hydrogen-bonded layers which are parallel to the ab plane. The I- anions are placed above and below each layer, and are hydrogen bonded both to U1 molecules and [CoU6]2+ cations. Each U2 molecule is connected to a [CoU6]2+ catio... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489854 Tue, 03 Jun 2008 22:25:23 +0100 1489854 http://www.medworm.com/index.php?rid=1489853&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F479897 A new series of Zn2+, Cu2+, Ni2+, and Co2+ complexes of N1-methyl-2-(1H-1,2,3-benzotriazol-1-yl)-3-oxobutanethioamide (MBOBT), HL, has been synthesized and characterized by different spectral and magnetic measurements and elemental analysis. IR spectral data indicates that (MBOBT) exists only in the thione form in the solid state while 13C NMR spectrum indicates its existence in thione and thiole tautomeric forms. The IR spectra of all complexes indicate that (MBOBT) acts as a monobasic bidentate ligand coordinating to the metal(II) ions via the keto-oxygen and thiolato-sulphur atoms. The electronic spectral studies showed that (MBOBT) bonded to all metal ions through sulphur and nitrogen atoms based on the positions and intensity of their charge transfer bands. Furthermore, the spectra... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489853 Tue, 03 Jun 2008 22:25:23 +0100 1489853 http://www.medworm.com/index.php?rid=1489852&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F294756 The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489852 Tue, 03 Jun 2008 22:25:23 +0100 1489852 http://www.medworm.com/index.php?rid=1489851&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F654137 A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)3Sn(TBA)⋅H2O] (1) has been synthesized and characterized by elemental analysis and 119Sn-NMR and FT-IR spectroscopic techniques. The crystal structure of complex 1 has been determined by single crystal X-ray diffraction analysis at 120(2) K. The geometry around Sn(IV) is trigonal bipyramidal. Three n-butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center. The geometry is completed with one oxygen from a water molecule. Compound 1 exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis. In addition, the inhi... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489851 Tue, 03 Jun 2008 22:25:23 +0100 1489851 http://www.medworm.com/index.php?rid=1489850&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F257038 The N- and C-terminal blocked hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide (LAHYNK) representing the 80–85 fragment of histone H2B was synthesized and its interactions with Cu(II) and Ni(II) ions were studied by potentiometric, UV-Vis, CD, EPR, and NMR spectroscopic techniques in solution. Our data reveal that the imidazole N(3) nitrogen atom is the primary ligating group for both metal ions. Sequential amide groups deprotonation and subsequent coordination to metal ions indicated an {Nimidazole,3Namide} coordination mode above pH∼9, in all cases. In the case of Cu(II)-peptide system, the almost exclusive formation of the predominant species CuL in neutral media accounting for almost 98% of the total metal ion concentration at pH 7.3 strongly indicates that at physiologica... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489850 Tue, 03 Jun 2008 22:25:23 +0100 1489850 http://www.medworm.com/index.php?rid=1489849&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F420578 In this study we analyzed blood and urine samples from shipyard industry welders being exposed to different levels of Cr(VI) over a period of five months in order to assay in vivo the relation of ApoJ/CLU serum levels with Cr(VI). Our findings confirmed the previously reported in vitro data since reduction of Cr levels, after a worksite intervention, associated with lower levels of ApoJ/CLU serum levels. We concluded that the human ApoJ/CLU gene is responsive to the acute in vivo oxidative stress induced by heavy metals such as hexavalent chromium. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489849 Tue, 03 Jun 2008 22:25:23 +0100 1489849 http://www.medworm.com/index.php?rid=1489848&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F469062 Molecular dynamics simulation of the interaction between the Tenebrio molitor alpha-amylase and its inhibitor at different proportion of crystal water was carried out with OPLS force field by hyperchem 7.5 software. In the correlative study, the optimal temperature of wheat monomeric and dimeric protein inhibitors was from 273 K to 318 K. The the average temperature of experimentation is 289 K. (1) The optimal temperature of interaction between alpha-amylase and its inhibitors was 280 K without crystal water that was close to the results of experimentation. The forming of enzyme-water and inhibitor-water was easy, but incorporating third monomer was impossible. (2) Having analyzed the potential energy data, the optimal temperature of interaction energy between a... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489848 Tue, 03 Jun 2008 22:25:23 +0100 1489848 http://www.medworm.com/index.php?rid=1489847&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F367471 The antineoplastic potential of a stable monomeric Au(II) complex with hematoporphyrin IX (Hp), namely [Au(II)Hp-2H.(H2O)2], was investigated in a panel of tumor cell lines. The complex exhibits strong cytotoxicity, whereby the leukaemia- and lymphoma-derived cell lines are more sensitive, with IC50 values comparable to those of the reference anticancer drug cisplatin. In contrast, the solid tumor models are more sensitive to the platinum drug. A comparative assessment of both agents against the human kidney cell line 293T has shown that [Au(II)Hp-2H.(H2O)2] is less cytotoxic. The gold complex induces oligonucleosomal DNA fragmentation in tumour cells following 24-hour treatment and hence its cytotoxic effect is at least partly mediated by induction of apoptotic cell death. A prominent int... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489847 Tue, 03 Jun 2008 22:25:23 +0100 1489847 http://www.medworm.com/index.php?rid=1489846&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F539082 The trivalent arsenic glutathione complexes arsenic triglutathione, methylarsonous diglutathione, and dimethylarsinous glutathione are key intermediates in the mammalian metabolism of arsenite and possibly represent the arsenic species that are transported from the liver to the kidney for urinary excretion. Despite this, the comparative stability of the arsenic-sulfur bonds in these complexes has not been investigated under physiological conditions resembling hepatocyte cytosol. Using size-exclusion chromatography and a glutathione-containing phosphate buffered saline mobile phase (5 or 10 mM glutathione, pH 7.4) in conjunction with an arsenic-specific detector, we chromatographed arsenite, monomethylars... Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489846 Tue, 03 Jun 2008 22:25:23 +0100 1489846 http://www.medworm.com/index.php?rid=1489845&cid=s_37044_60_f&fid=37044&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F983725 A sequence of stages in the syntheses of isomeric bisamino acid complexes of Pt(II) with β-aminopropionic acid (β-alanine = β-AlaH) has been studied by the P195t NMR spectroscopy. The techniques have been developed of the synthesis of the cis- and trans-bischelates of Pt(II) and Pd(II) with β-alanine as well as of the halide complexes of trans-[M(β-AlaH)2Cl2] (M = Pt, Pd) and trans-K2[Pt(β-Ala)2I2] types. The NMR spectroscopy and IR spectroscopy (in the nuclei of P195t,C13,H1) and X-ray diffraction analysis have been used to examine the structures of the synthesized compounds. (Source: Bioinorganic Chemistry and Applications) Bioinorganic Chemistry and Applications journals http://www.medworm.com/rss/comments.php?id=1489845 Tue, 03 Jun 2008 22:25:23 +0100 1489845