Breast Cancer Research and Treatment via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Breast Cancer Research and Treatment' source. Sat, 20 Mar 2010 13:49:41 +0100 The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells http://www.medworm.com/index.php?rid=3375457&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp583351kr2816571%2F In this study, β2-AR level was found to be up-regulated in MCF-7 cells overexpressing Her2 (MCF-7/Her2). Correlation of β2-AR level with Her2 status was demonstrated in breast cancer tissue samples. Constitutive phosphorylation of ERK, mRNA expression up-regulation of catecholamine-synthesis enzymes, and increased epinephrine release were detected in MCF-7/Her2 cells. β2-AR expression induced by epinephrine and involvement of ERK signaling were validated. The data indicate that Her2 overexpression and excessive phosphorylation of ERK cause epinephrine autocrine release from breast cancer cells, resulting in up-regulation of β2-AR expression. The data also showed that catecholamine prominently stimulated Her2 mRNA expression and promoter activity. The activation and nuclear transl... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3375457 Tue, 16 Mar 2010 14:50:08 +0100 3375457 Association of TGFB1 -509 C>T polymorphism with breast cancer: evidence from a meta-analysis involving 23,579 subjects http://www.medworm.com/index.php?rid=3371335&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F91mgx74907657271%2F Abstract  Although a number of genetic studies have attempted to link transforming growth factor beta 1 gene (TGFB1) -509 C>T polymorphism to breast cancer, the results were often irreproducible. We therefore aimed to meta-analyze all available case–control studies from the English-published literature to explore the association of this polymorphism with breast cancer. A total of 6 studies with 9 populations involving 10,197 patients and 13,382 controls were identified as of February 20, 2010. A random-effects model was performed irrespective of the between-study heterogeneity. Study quality was assessed in duplicate. The frequencies of TGFB1 -509 T allele in patients and controls ranged from 21.72 to 51.74%, and 24.53 to 52.40%, respectively. The presence of -509 T all... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3371335 Mon, 15 Mar 2010 17:58:17 +0100 3371335 Identification of a new complex deleterious mutation in exon 18 of the BRCA2 gene in a hereditary male/female breast cancer family http://www.medworm.com/index.php?rid=3371337&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F00038042t2418723%2F We report a novel complex mutation that consists of a deletion of 12 bp and an insertion of 2 bp (c.8402_8413del12ins2bp) in the exon 18 of the BRCA2 gene. This is a frameshift mutation that causes a disruption of the translational reading frame resulting in a stop codon downstream in the 2729 position of the BRCA2 protein. The mutation was present in a Spanish hereditary male/female breast cancer family. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s10549-010-0830-2Authors Orland Diez, University Hospital Vall d’Hebron Oncogenetics Laboratory 08035 Barcelona SpainSara Gutiérrez-Enríquez, Vall d’Hebron Institute of Oncology (VHIO) Barcelona SpainMiriam Masas, University Hospital Vall d’Hebron Oncogenetics Laboratory 08035 Barcelona SpainAnna Ten... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3371337 Mon, 15 Mar 2010 17:58:15 +0100 3371337 Targeting trastuzumab-resistant breast cancer cells with a lentivirus engineered to bind antibodies that recognize HER-2 http://www.medworm.com/index.php?rid=3371336&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq47227hk40637m83%2F In conclusion, HER-2 over-expressing breast cancer cells resistant to trastuzumab can be targeted for selective gene expression and destruction by viruses with envelope-proteins engineered to bind to this antibody. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0828-9Authors Kai-xin Zhang, The Vancouver Prostate Centre 2660 Oak Street Vancouver BC V6H-3Z6 CanadaConnie Kim, The Vancouver Prostate Centre 2660 Oak Street Vancouver BC V6H-3Z6 CanadaElaine Chow, The Vancouver Prostate Centre 2660 Oak Street Vancouver BC V6H-3Z6 CanadaIrvin S. Y. Chen, University of California, Los Angeles David Geffen School of Medicine Los Angeles CA USAWilliam Jia, University of British Columbia Department of Surgery and Brain Research Centre Vancouver BC CanadaPaul S. R... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3371336 Mon, 15 Mar 2010 17:58:15 +0100 3371336 Large genomic rearrangements of the BRCA1 and BRCA2 genes: review of the literature and report of a novel BRCA1 mutation http://www.medworm.com/index.php?rid=3371338&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyhn3173330pm5x23%2F Abstract  Germline mutations in BRCA1 and BRCA2 increase the risk for developing breast and ovarian cancer. Previously, the techniques available allowed only for the identification of small genomic alterations, but the dawn of new technology now allows for the rapid detection of large genomic rearrangements (LGRs). LGRs in BRCA1 are responsible for between 0 and 27% of all BRCA1 disease-causing mutations identified in numerous populations. Such alterations are far less common in the BRCA2 gene. To determine the impact of BRCA1 and BRCA2 LGRs in South Africa, 52 hereditary breast and/or ovarian South African families (36 were Afrikaners) were screened for BRCA1 and BRCA2 LGRs using multiplex ligation-dependent probe amplification. These patients were previously shown to be B... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3371338 Mon, 15 Mar 2010 17:58:14 +0100 3371338 Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins http://www.medworm.com/index.php?rid=3366964&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F854862hj10265562%2F Abstract  Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholine receptors increases cyclin D1 promoter activity and protein expression. The main purpose of this study is to elucidate the carcinogenic role of cyclin D3, which is involved in breast tumorigenesis when induced by Nic. Real-time PCR analysis revealed that cyclin D3 is highly expressed at the mRNA level in surgically dissected breast tumor tissue, compared to the surrounding normal tissue (tumor/normal fold ratio = 17.93, n = 74). To test whether Nic/nicotinic acetylcholine receptor (nAChR) binding could affect cyclin D3 expression in human breast cancer cells, the transformed cell line MCF-10A-Nic (... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3366964 Sun, 14 Mar 2010 11:26:12 +0100 3366964 Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer http://www.medworm.com/index.php?rid=3366966&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff14253765wm1m3t3%2F Abstract  Patients with ER/PR/HER2-negative (triple negative) breast cancer are not candidates for hormonal therapy or HER2-targeted agents. Ongoing research is aimed at identifying and understanding the benefit of established and emerging therapies in this disease setting. Triple-negative patients may achieve early responses to anthracyclines and taxanes, but novel strategies are also eagerly sought. The epothilone B analog ixabepilone acts to stabilize microtubules and demonstrates antitumor activity in recent breast cancer studies. Herein, we have analyzed efficacy and safety data of ixabepilone specifically for the treatment of women with triple-negative disease. A retrospective analysis was completed using activity and toxicity data in the triple-negative subsets from ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3366966 Sun, 14 Mar 2010 11:26:10 +0100 3366966 Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy http://www.medworm.com/index.php?rid=3366965&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp1w0l64t547qknpw%2F Abstract  The Forkhead Box Protein 3 is highly expressed not only in regulatory T cells, but also in tumor cells, acting as a transcriptional repressor of breast oncogenes including HER2. We investigated the prognostic significance of Foxp3 expression in cancer cells in a large cohort of patients with HER2-overexpressing breast carcinoma treated with neoadjuvant chemotherapy. Foxp3-positive tumor cells were detected by immunohistochemistry in 103 patients with primary invasive HER2-overexpressing breast carcinoma, and treated with neoadjuvant chemotherapy, with or without trastuzumab. Kaplan–Meier analysis and Cox regression model were used to assess relapse-free and overall survival, respectively, and according to the presence or the absence of Foxp3 expression in tumor c... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3366965 Sun, 14 Mar 2010 11:26:10 +0100 3366965 Biological and clinical implications of nicastrin expression in invasive breast cancer http://www.medworm.com/index.php?rid=3360373&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4243855l5g26224%2F Abstract  Nicastrin is an essential component of the gamma secretase (GS) enzyme complex, required for its synthesis and recognition of substrates for proteolytic cleavage. The purpose of this study was to investigate whether nicastrin has prognostic value or potential as a therapeutic target in breast cancer (BC). The suitability of nicastrin as a target in BC was assessed using BC tissue microarrays (TMAs) (n = 1050), and its biological role in vitro was evaluated in BC cell lines following gene silencing. Nicastrin blocking antibodies were developed and evaluated for their suitability as potential clinical therapeutics. TMA and cell line analysis confirmed that nicastrin expression was upregulated in BC compared to normal breast cells. In TMA patient samples, hi... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3360373 Thu, 11 Mar 2010 18:24:24 +0100 3360373 Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells http://www.medworm.com/index.php?rid=3360374&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F95458755434p4p04%2F Abstract  Here we evaluated the cytotoxic effects of a combination of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and taxanes in human breast cancer cell lines. Combination treatment with taxane and SAHA had a synergistic cytotoxic effect against taxane-resistant breast cancer cells. Oligonucleotide microarray analysis identified 28 genes (MAPK13, ATP2C1, ANKRD57, MT1G, RGL4, C12orf49, EXOC6, RAB4A, TM9SF3, IFNGR1, DMD, HCG9, KIFC3, SYNGR3, NDRG4, NT5E, EOMES, SMC4, LANCL1, SCHIP1, and 8 ESTs) whose expression correlated with the combined effect of paclitaxel and SAHA. Twelve of these genes were down-regulated in cell lines that were paclitaxel-resistant but combination synergistic. SAHA induced NT5E mRNA expression in paclitaxel-resistant YCC-B1 c... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3360374 Thu, 11 Mar 2010 18:24:08 +0100 3360374 Absence of genomic BRCA1 and BRCA2 rearrangements in Ashkenazi breast and ovarian cancer families http://www.medworm.com/index.php?rid=3360375&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa75127x711073n13%2F Abstract  A substantial proportion of Ashkenazi Jewish (AJ) breast and ovarian cancer families carry one of three founder mutations in BRCA1 (185delAG, 5382InsC) and BRCA2 (6174delT). Non-founder mutations are identified in another 2–4% of such families. The extent to which major genomic rearrangements in BRCA contribute to breast and ovarian cancer in the Ashkenazim is not well understood. We identified AJ individuals with breast and/or ovarian cancer undergoing hereditary breast/ovarian cancer risk assessment since 2006 without evidence of a deleterious mutation on BRCA gene sequencing who were screened for major gene rearrangements in BRCA1 and BRCA2. For each proband, the pre-test probability of identifying a deleterious BRCA mutation was estimated using the Myriad II m... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3360375 Thu, 11 Mar 2010 02:45:44 +0100 3360375 Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines http://www.medworm.com/index.php?rid=3360376&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F97051r428n285888%2F Abstract  A large proportion of breast cancers expresses the estrogen receptor alpha (ERα) and are dependent on estrogens for their proliferation and survival. The tumor suppressor TP53 encodes the p53 protein, an important mediator of the anti-proliferative and apoptotic effects of several treatments used for breast cancer. A significant proportions of breast tumors (20–30%) carry mutations in TP53 gene and these mutations are associated with poor survival and poor response to several types of chemotherapeutic treatments. While there is mounting evidence for functional interactions between p53 and ERα pathways in breast and other tissues, the impact of these interactions on response to chemotherapy and anti-hormone treatments remain largely unknown. Here, using estrogen-... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3360376 Thu, 11 Mar 2010 02:45:42 +0100 3360376 Loss of ICAM-1 signaling induces psoriasin (S100A7) and MUC1 in mammary epithelial cells http://www.medworm.com/index.php?rid=3355584&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft11428u307056725%2F Abstract  Psoriasin (S100A7), a member of the S100 gene family, is highly expressed in high-grade comedo ductal carcinoma in situ (DCIS), with a higher risk of local recurrence. Psoriasin is, therefore, a potential biomarker for DCIS with a poor prognosis. High-grade DCIS is characterized by a high proliferation rate and crowded cells, consequently, lose contact with the extracellular matrix. The aim of this study was, therefore, to elucidate the involvement of adhesion signals in the regulation of psoriasin. Protein expression was evaluated by Western blotting, flow cytometry, and immunohistochemistry, and using breast carcinoma SAGE databases available from the CGAP website. Intercellular adhesion molecule 1 (ICAM-1) was down-regulated in MCF10A cells using short hairpin ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355584 Wed, 10 Mar 2010 13:17:34 +0100 3355584 Immunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cells http://www.medworm.com/index.php?rid=3355585&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjt4q3661tj8002g0%2F Abstract  Trastuzumab is a FDA-approved drug that has shown clinical efficacy against HER2+ breast cancers and is commonly used in combination with other chemotherapeutics. However, many patients are innately resistant to trastuzumab, or will develop resistance during treatment. Alternative treatments are needed for trastuzumab-resistant patients. Here, we investigate gold nanoparticle-mediated photothermal therapies as a potential alternative treatment for chemotherapy-resistant cancers. Gold nanoshell photothermal therapy destroys the tumor cells using heat, a physical mechanism, which is able to overcome the cellular adaptations that bestow trastuzumab resistance. By adding anti-HER2 to the gold surface of the nanoshells as a targeting modality, we increase the specifici... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355585 Wed, 10 Mar 2010 13:17:33 +0100 3355585 PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer http://www.medworm.com/index.php?rid=3355586&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr00841u172h86821%2F Abstract  Phosphorylation of estrogen receptor α at serine 305 (ERαS305-P) by protein kinase A (PKA) or p21-activated kinase 1 (PAK1) has experimentally been associated with tamoxifen sensitivity. Here, we investigated the clinical application of this knowledge to predict tamoxifen resistance in ER-positive breast cancer patients. Using immunohistochemistry, a score including PAK1 and co-expression of PKA and ERαS305-P (PKA/ERαS305-P) was developed on a training set consisting of 103 patients treated with tamoxifen for metastatic disease, and validated on 231 patients randomized between adjuvant tamoxifen or no treatment. In the training set, PAK1 levels were associated with tumor progression after tamoxifen (HR 1.57, 95% CI 0.99–2.48), as was co-expression of PKA and... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355586 Wed, 10 Mar 2010 13:17:31 +0100 3355586 Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma http://www.medworm.com/index.php?rid=3355587&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4182r49t8362276%2F In conclusion, this study suggests that HAb18G expression is associated with BC progression and prognosis. Further evaluation of this new marker in breast cancer is indicated. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0790-6Authors Fangfang Liu, Cancer Hospital of Tianjin Medical University Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research Tianjin 300060 ChinaLifang Cui, Cancer Hospital of Tianjin Medical University Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research Tianjin 300060 ChinaYang Zhang, Fourth Military Medical University Cell Engineering Research Centre & Department of Cell Biology, State Key Laboratory of Cancer Biolo... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355587 Wed, 10 Mar 2010 13:17:30 +0100 3355587 Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population http://www.medworm.com/index.php?rid=3355588&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy2k05v20h532745q%2F Abstract  Trinucleotide repeat-containing 9 (TNRC9), a high mobility group chromatin-associated protein, has been implicated in breast cancer metastasis to the bone. Recently, several single nucleotide polymorphisms (SNPs) of TNRC9 were identified as novel breast cancer susceptibility loci by whole genome association studies, especially in estrogen receptor (ER) positive tumors. In the present case–control study of 1,049 breast cancer patients and 1,073 cancer-free controls in a Chinese population, we genotyped three polymorphisms (rs3803662C/T, rs12443621A/G, and rs8051542C/T) of the TNRC9 gene using the SNPstream 12-plex platform to test the hypothesis that these SNPs are associated with breast cancer risk in this population. None of the three polymorphisms was significan... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355588 Wed, 10 Mar 2010 13:17:21 +0100 3355588 Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study http://www.medworm.com/index.php?rid=3355591&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7v074m0p6516u0gq%2F In conclusion, CTTN is consistently co-amplified with CCND1 and expressed at higher levels in breast cancers harbouring 11q13 amplification, suggesting that CTTN may also constitute one of the drivers of this amplicon. CTTN expression is not associated with the outcome of breast cancer patients treated with anthracycline-based chemotherapy. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0816-0Authors Konstantin J. Dedes, Institute of Cancer Research The Breakthrough Breast Cancer Research Centre 237 Fulham Road London SW3 6JB UKMaria-Angeles Lopez-Garcia, Institute of Cancer Research The Breakthrough Breast Cancer Research Centre 237 Fulham Road London SW3 6JB UKFelipe C. Geyer, Institute of Cancer Research The Breakthrough Breast Cancer Research Centr... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355591 Wed, 10 Mar 2010 13:17:16 +0100 3355591 PALB2 mutations 1592delT and 229delT are not present in Korean breast cancer patients negative for BRCA1 and BRCA2 mutations http://www.medworm.com/index.php?rid=3355590&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F70l25l43701851j1%2F In this study, we evaluated the frequency of PALB2 1592delT and 229delT mutations in 300 Korean breast cancer patients diagnosed with either familial or early-onset breast cancer. All patients were confirmed negative for BRCA1 and BRCA2 mutations. Neither 1592delT nor 229delT mutations was found in any of the study cohort. Our results imply that these mutations are absent or rare in Korean patients who are negative for BRCA1 and BRCA2 mutations. We found no evidence to recommend screening for these mutations in the Korean population. However, PALB2 mutations have been demonstrated infrequent and inhomogeneous across investigated populations. Thus, screening the whole PALB2 gene for novel mutations is required to elucidate its significance in predisposition to breast cancer in Korean wo... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355590 Wed, 10 Mar 2010 13:17:16 +0100 3355590 The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: cytotoxic drug and inducer of sodium-iodide symporter (NIS) http://www.medworm.com/index.php?rid=3355589&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7t48872432028254%2F In conclusion, our data suggest that LBH589 might be a powerful tool in the management of breast cancer due to its multiple effects and support a potential application of LBH589 in the diagnosis and treatment of this disease. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0789-zAuthors N. Fortunati, AOU San Giovanni Battista, University of Turin Oncological Endocrinology Turin ItalyM. G. Catalano, University of Turin Department of Clinical Pathophysiology Via Genova 3 10126 Turin ItalyF. Marano, AOU San Giovanni Battista, University of Turin Oncological Endocrinology Turin ItalyV. Mugoni, AOU San Giovanni Battista, University of Turin Oncological Endocrinology Turin ItalyM. Pugliese, University of Turin Department of Clinical Pathophysiology Via Genova... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355589 Wed, 10 Mar 2010 13:17:16 +0100 3355589 The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer http://www.medworm.com/index.php?rid=3355592&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6461010871n6178%2F In this study, we assessed the additional predictive value of the 70-gene MammaPrint signature for chemotherapy (CT) benefit in addition to endocrine therapy (ET) from pooled study series. For 541 patients who received either ET (n = 315) or ET + CT (n = 226), breast cancer-specific survival (BCSS) and distant disease-free survival (DDFS) at 5 years were assessed separately for the 70-gene high and low risk groups. The 70-gene signature classified 252 patients (47%) as low risk and 289 (53%) as high risk. Within the 70-gene low risk group, BCSS was 97% for the ET group and 99% for the ET + CT group at 5 years with a non-significant univariate hazard ratio (HR) of 0.58 (95% CI 0.07–4.98; P = 0.62). In the 70-gene high risk g... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355592 Wed, 10 Mar 2010 13:17:14 +0100 3355592 XPD Lys751Gln polymorphism and breast cancer susceptibility: a meta-analysis involving 28,709 subjects http://www.medworm.com/index.php?rid=3355594&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F622212644p3q3128%2F In conclusion, this meta-analysis suggests that the XPD 751Gln allele is a low-penetrant risk factor for developing breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0813-3Authors Li-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaJian Zhang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaXiao-Dong Zhu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaXin-Min Zhao, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaKai Xue, Fudan University Department of Medical Oncology, Cancer Hospital ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355594 Wed, 10 Mar 2010 13:17:13 +0100 3355594 The association between two polymorphisms of eNOS and breast cancer risk: a meta-analysis http://www.medworm.com/index.php?rid=3355593&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe354wv3610425j6k%2F In conclusion, this meta-analysis suggests that both eNOS E298D and −786T>C polymorphisms are associated with reduced breast cancer risk. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0800-8Authors Lei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai 200433 People’s Republic of ChinaFang Fang, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai 200433 People’s Republic of ChinaYang Zhong, Fudan University Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sciences Shanghai 200433 ChinaLong Yu, Fudan University State Key Laboratory of Genetic Engineering, In... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355593 Wed, 10 Mar 2010 13:17:13 +0100 3355593 Are there racial/ethnic disparities among women younger than 40 undergoing mammography? http://www.medworm.com/index.php?rid=3355595&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmp32753l60585570%2F This study of community-based practice found racial/ethnic variability in mammography indication, recommendations, and outcomes among women undergoing first mammography before 40. These findings highlight important areas for future research to understand the motivating factors for these practice patterns and the implications of early mammography use. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0812-4Authors Julie M. Kapp, University of Missouri Department of Family and Community Medicine MA306 Medical Sciences Bldg, 1 Hospital Drive Columbia MO 65212 USARod Walker, Group Health Research Institute Seattle WA USASebastien Haneuse, Group Health Research Institute Seattle WA USADiana S. M. Buist, Group Health Research Institute Seattle WA USABonnie C. Yank... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355595 Wed, 10 Mar 2010 13:17:12 +0100 3355595 Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families: high cancer incidence at older age http://www.medworm.com/index.php?rid=3355596&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5pn411t128013733%2F Abstract  Accurate estimations of lifetime risks of breast and ovarian cancer are crucial for counselling women from BRCA1/2 families. We therefore determined breast and ovarian cancer penetrance in BRCA1/2 mutation families in the northern Netherlands and compared them with the incidence of cancers in the general population in this region. We identified 1188 female mutation carriers and first-degree female relatives in 185 families with a pathogenic BRCA1 or BRCA2 mutation. The occurrence of breast cancer, contralateral breast cancer and ovarian cancer was recorded. The cumulative incidence of breast cancer by age 70 was 71.4% (95% CI 67.2–82.4%) in BRCA1 and 87.5% (82.4–92.6%) in BRCA2 mutation carriers. For ovarian cancer at age 70, it was 58.9% (53.5–64.3%) in BRCA1 ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3355596 Wed, 10 Mar 2010 13:17:09 +0100 3355596 Adjuvant!© Online estimation of chemotherapy effectiveness when added to ovarian function suppression plus tamoxifen for premenopausal women with estrogen-receptor-positive breast cancer http://www.medworm.com/index.php?rid=3328308&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl13235l4u6720361%2F Abstract  Adjuvant!© Online (Adjuvant!) is a user-friendly, web-based tool that provides estimates of adjuvant therapy outcomes for individual patients. While reliable evidence underpins estimates for most patient cohorts, there is a paucity of data on the effect of adding chemotherapy to complete estrogen blockade for premenopausal women with estrogen-receptor positive breast cancer. International Breast Cancer Study Group (IBCSG) Trial 11-93 enrolled 174 premenopausal women with estrogen-receptor positive, node-positive breast cancer. Among these patients, 55% had one positive axillary lymph node and 97% had three or fewer positive nodes. Patients were randomized to receive ovarian function suppression plus 5 years of tamoxifen with or without anthracycline-based che... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3328308 Tue, 02 Mar 2010 10:05:47 +0100 3328308 Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode http://www.medworm.com/index.php?rid=3315459&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0gp9151j5189072%2F Abstract  Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribu... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3315459 Fri, 26 Feb 2010 16:44:08 +0100 3315459 Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells http://www.medworm.com/index.php?rid=3315460&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm45v206t18108527%2F In conclusion, Id1/3-PA7 could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expression of Id1 and Id3. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0810-6Authors Demissew S. Mern, German Cancer Research Center Helmholtz-University Group Molecular Epidemiology Im Neuenheimer Feld 581 69120 Heidelberg GermanyKarin Hoppe-Seyler, German Cancer Research Center Molecular Therapy of Virus-Associated Cancers Im Neuenheimer Feld 242 69120 Heidelberg GermanyFelix Hoppe-Seyler, German Cancer Research Center Molecular Therapy of Virus-Associated Cancers Im Neuenheimer Feld 242 69120 Heidelberg GermanyJens Hasskarl, University of Freiburg M... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3315460 Fri, 26 Feb 2010 09:43:25 +0100 3315460 Increased MUTYH mutation frequency among Dutch families with breast cancer and colorectal cancer http://www.medworm.com/index.php?rid=3315461&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv7131013l207557g%2F Abstract  Homozygous and compound heterozygous MUTYH mutations predispose for MUTYH-associated polyposis (MAP). The clinical phenotype of MAP is characterised by the multiple colorectal adenomas and colorectal carcinoma. We previously found that female MAP patients may also have an increased risk for breast cancer. Yet, the involvement of MUTYH mutations in families with both breast cancer and colorectal cancer is unclear. Here, we have genotyped the MUTYH p.Tyr179Cys, p.Gly396Asp and p.Pro405Leu founder mutations in 153 Dutch families with breast cancer patients and colorectal cancer patients. Families were classified as polyposis, revised Amsterdam criteria positive (FCRC-AMS positive), revised Amsterdam criteria negative (FCRC-AMS negative), hereditary breast and colorecta... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3315461 Fri, 26 Feb 2010 09:43:24 +0100 3315461 Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4 http://www.medworm.com/index.php?rid=3312738&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq527427473827833%2F Abstract  Bone morphogenetic proteins (BMP) are extracellular signaling molecules that belong to the transforming growth factor β (TGFβ) superfamily. Bone morphogenetic proteins have diverse roles during development where they regulate proliferation, differentiation, and apoptosis in many different cell types by modulating the transcription of specific target genes. BMPs have also been implicated in both promotion and inhibition of cancer progression. We have recently shown that BMP4 is commonly expressed in breast cancer but its functional significance has not been previously explored. Our data demonstrate that in all nine breast cancer cell lines studied, BMP4 treatment leads to a dramatic growth suppression as a result of the induction of G1 arrest of the cell cycle. A... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3312738 Thu, 25 Feb 2010 08:07:15 +0100 3312738 Weight gain is associated with increased risk of hot flashes in breast cancer survivors on aromatase inhibitors http://www.medworm.com/index.php?rid=3312737&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq5271446t217n287%2F This study tested if body size is associated with hot flashes in BCS on AI therapy. A cross-sectional study of postmenopausal BCS receiving adjuvant AI therapy was performed. The primary outcome was occurrence of patient-reported hot flashes. The primary exposures of interest were current body size and weight change since breast cancer diagnosis. Three hundred participants were enrolled at a mean age of 61 years (range 33–86) after an average AI exposure of 23 months (range 1 month–9 years). Fifty-nine percent reported hot flashes, 32% reported moderate to severe hot flashes, and 25% reported significant worsening of hot flashes since starting AI therapy. Sixty-one percent experienced weight maintenance (±10 lb), while 27% had weight gain (gained 10&nbsp... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3312737 Thu, 25 Feb 2010 08:07:15 +0100 3312737 NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis http://www.medworm.com/index.php?rid=3308104&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu5t0283207160ll8%2F In conclusion, this meta-analysis suggested that there is overall lack of association between NAT2 genotypes and breast cancer risk, however, NAT2 polymorphisms when combining with heavy smoking history may contribute to breast cancer susceptibility. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0807-1Authors Jian Zhang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLi-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaZhong-Hua Wang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaJia-Lei Wang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaShuang-Shuang He, Shanghai Jiaotong University Affiliated First People’s Hospital ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3308104 Wed, 24 Feb 2010 06:52:41 +0100 3308104 PALB2 mutations in male breast cancer: a population-based study in Central Italy http://www.medworm.com/index.php?rid=3308105&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb73833366016r217%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-010-0797-zAuthors Valentina Silvestri, “Sapienza” University of Rome Department of Experimental Medicine 00161 Rome ItalyPiera Rizzolo, “Sapienza” University of Rome Department of Experimental Medicine 00161 Rome ItalyInes Zanna, Cancer Research and Prevention Institute—ISPO Molecular and Nutritional Epidemiology Unit 50139 Florence ItalyMario Falchetti, “Sapienza” University of Rome Department of Experimental Medicine 00161 Rome ItalyGiovanna Masala, Cancer Research and Prevention Institute—ISPO Molecular and Nutritional Epidemiology Unit 50139 Florence ItalySimonetta Bianchi, University of Florence Department of Pathology 50139 Florence ItalyLaura Papi, University of Florence Medical Genetics ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3308105 Wed, 24 Feb 2010 06:52:39 +0100 3308105 Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers http://www.medworm.com/index.php?rid=3308107&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F27h5720122828162%2F Abstract  Risk-reducing salpingo-oophorectomy (RRSO) is widely used for cancer risk reduction in BRCA1 or BRCA2 (BRCA1/2) mutation carriers. Occult ovarian/fallopian tube cancers (OOC) detected at the time of RRSO have been reported in several studies with wide variability in reported prevalence. We estimated the prevalence of OOC in a prospective cohort of 647 BRCA1/2 mutation carriers from 18 centers (PROSE consortium) who underwent RRSO between 2001 and 2008. OOC was detected in 16 of 647 women (2.5%). The mean age at RRSO was 51.7 in those with OOC versus 46.6 in those without OOC (P = 0.017). Twelve of the 16 OOCs (75%) were diagnosed in women with BRCA1 mutations. Thirty-eight percent of women with OOC had stage 1 cancer versus none of the women in the PROSE dat... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3308107 Wed, 24 Feb 2010 06:52:37 +0100 3308107 Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case–control study in Thai women http://www.medworm.com/index.php?rid=3308106&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa0213h1h1248x602%2F Abstract  Dietary folate as well as polymorphic variants in one-carbon metabolism genes may modulate risk of breast cancer through aberrant DNA methylation and altered nucleotide synthesis and repair. Alcohol is well recognized as a risk factor for breast cancer, and interactions with one-carbon metabolism has also been suggested. The purpose of this study is to test the hypothesis that genetic polymorphisms in the folate and alcohol metabolic pathway are associated with breast cancer risk. Twenty-seven single nucleotide polymorphisms (SNPs) in the MTR, MTRR, MTHFR, TYMS, ADH1C, ALDH2, GSTP1, NAT1, NAT2, CYP2E1 DRD2, DRD3, and SLC6A4 were genotyped. Five hundred and seventy patients with histopathogically confirmed breast cancer and 497 controls were included in the present ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3308106 Wed, 24 Feb 2010 06:52:37 +0100 3308106 Effect of air travel on lymphedema risk in women with history of breast cancer http://www.medworm.com/index.php?rid=3308108&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr45j002l074xt000%2F Abstract  To assess the impact of air travel on swelling of the ‘at risk’ arm of women treated for breast cancer. Women treated for breast cancer from Canada (n = 60) and from within Australia (n = 12) attending a dragon boat regatta in Queensland, Australia participated. Women were measured within 2 weeks prior to their flight, on arrival in Queensland and, for 40 women travelling from Canada, measured again 6 weeks following return to Canada. Changes to extracellular fluid were measured using a single-frequency bioimpedance device (BIA). Each arm was measured separately using a standardized protocol to obtain the inter-limb impedance ratio. An increase in the ratio indicates accumulated fluid. Information regarding medical management of partici... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3308108 Wed, 24 Feb 2010 06:52:36 +0100 3308108 Adipocytokine resistin and breast cancer risk http://www.medworm.com/index.php?rid=3303648&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx76588344271g186%2F Abstract  Adipocytokine resistin is a member of the newly discovered family of cysteine-rich protein. Recent data suggest that macrophages are a major source of human resistin. Given the obesity-breast cancer link and convergence of adipocyte and macrophage function, resistin may provide unique insight into links between obesity, inflammation, and breast cancer risk in humans. We conducted a hospital-based case–control study to evaluate whether plasma resistin levels were associated with breast cancer risk in women. We also examined the modification effect of estrogen exposures on the resistin–breast cancer link. Questionnaire information, anthropometric measures, and blood samples were taken before treatment from 380 incident cases with breast cancer and 760 controls a... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3303648 Tue, 23 Feb 2010 07:53:46 +0100 3303648 High levels of uPA and PAI-1 predict a good response to anthracyclines http://www.medworm.com/index.php?rid=3303649&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6t3724j82225k806%2F Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s10549-010-0795-1Authors Kathleen I. Pritchard, University of Toronto Sunnybrook Odette Cancer Centre, Sunnybrook Health Sciences Centre Toronto Canada Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3303649 Tue, 23 Feb 2010 07:53:45 +0100 3303649 TGF-β1 29T/C polymorphism and breast cancer risk: a meta-analysis involving 25,996 subjects http://www.medworm.com/index.php?rid=3295547&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy814485pq6wk5183%2F Abstract  Transforming growth factor β1 (TGF-β1) is a cytokine, playing an important role in controlling cell proliferation and differentiation involved in breast cancer. It was reported the 29T/C polymorphism in TGF-β1 has been implicated in breast cancer risk. However, studies on the association between this polymorphism and breast cancer remain conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 10,341 cases and 15,655 controls from fifty published case-control studies was performed. Our analysis suggested that 29T/C has no association with a trend of breast cancer risk when using both dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI) 0.96–1.07] and recessive models (OR = 0.98, 95% CI 0.89–1.08)... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3295547 Sun, 21 Feb 2010 06:56:08 +0100 3295547 Predictors of interobserver agreement in breast imaging using the Breast Imaging Reporting and Data System http://www.medworm.com/index.php?rid=3295548&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp8601u2g898q71gn%2F Abstract  The Breast Imaging Reporting and Data System (BI-RADS) was introduced in 1993 to standardize the interpretation of mammograms. Though many studies have assessed the validity of the system, fewer have examined its reliability. Our objective is to identify predictors of reliability as measured by the kappa statistic. We identified studies conducted between 1993 and 2009 which reported kappa values for interpreting mammograms using any edition of BI-RADS. Bivariate and multivariate multilevel analyses were used to examine associations between potential predictors and kappa values. We identified ten eligible studies, which yielded 88 kappa values for the analysis. Potential predictors of kappa included: whether or not the study included negative cases, whether single-... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3295548 Sun, 21 Feb 2010 06:56:07 +0100 3295548 Personal breast: customizing agents and biomarkers for optimal adjuvant endocrine therapy http://www.medworm.com/index.php?rid=3280946&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6670065qg3x24521%2F Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s10549-010-0787-1Authors Aditya Bardia, Johns Hopkins School of Medicine Sidney Kimmel Comprehensive Cancer Center 1650 Orleans Street, CRBI, Room 186 Baltimore MD 21231 USAVered Stearns, Johns Hopkins School of Medicine Sidney Kimmel Comprehensive Cancer Center 1650 Orleans Street, CRBI, Room 145 Baltimore MD 21231 USA Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3280946 Tue, 16 Feb 2010 18:09:06 +0100 3280946 Aromatase inhibitor-induced arthralgia in early breast cancer: what do we know and how can we find out more? http://www.medworm.com/index.php?rid=3277098&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4002314371558505%2F Abstract  Aromatase inhibitors (AIs) are a standard of care for the adjuvant treatment of hormone responsive early carcinoma of the breast as demonstrated in a number of large international phase III randomised trials. Arthralgia was a somewhat unexpected side effect of this class of agents and has proven to be potentially problematic in clinical practice. Although rates of up 35% have been reported in the randomised trials, the figure has been much higher in subsequent case series. There is concern that these symptoms are significant and may affect compliance and thus the overall efficacy of treatment. It is therefore extremely important that we evaluate this syndrome with a view to gaining more information regarding its clinical features and possible aetiological mechanis... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3277098 Mon, 15 Feb 2010 18:02:19 +0100 3277098 TGFB1 T29C polymorphism and breast cancer risk: a meta-analysis based on 10,417 cases and 11,455 controls http://www.medworm.com/index.php?rid=3277100&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb54253xu2u4g0835%2F In conclusion, the present meta-analysis suggests that the TGFB1 T29C polymorphism is not a low-penetrant risk factor for developing breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0766-6Authors Dongying Gu, The Affiliated Nanjing First Hospital, Nanjing Medical University Department of Oncology 68 Changle Road Nanjing 210006 People’s Republic of ChinaLuhong Zhuang, The Affiliated Nanjing First Hospital, Nanjing Medical University Department of Oncology 68 Changle Road Nanjing 210006 People’s Republic of ChinaHuaying Huang, The Affiliated Nanjing First Hospital, Nanjing Medical University Department of Oncology 68 Changle Road Nanjing 210006 People’s Republic of ChinaPing Cao, The Affiliated Nanjing First Hospital, Nanjing Medical Universi... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3277100 Mon, 15 Feb 2010 18:02:18 +0100 3277100 Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling http://www.medworm.com/index.php?rid=3277099&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb1w5721132730145%2F This study focused on investigating anticancer effects of tocotrienols and the mechanisms of apoptosis induction by tocotrienols in vivo and in vitro. Dietary delivery of γ-tocotrienol (γ-T3) suppressed tumor growth in a syngeneic implantation mouse mammary cancer model by inhibiting cell proliferation and inducing apoptosis. In cell culture studies, γ-T3 inhibited colony formation of a mouse mammary cancer cell line and human breast cancer cell lines. The anti-proliferative effects of tocotrienols were highly correlated with an increase in apoptosis based on Annexin V assessment. Treatment of human MDA-MB-231 and MCF-7 cells with γ-T3 induced cleavages of PARP as well as caspase-8, -9, and -3. Additional analyses showed that γ-T3 activated c-Jun NH2-terminal kinase (J... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3277099 Mon, 15 Feb 2010 18:02:18 +0100 3277099 Common genetic variation of insulin-like growth factor-binding protein 1 (IGFBP-1), IGFBP-3, and acid labile subunit in relation to serum IGF-I levels and mammographic density http://www.medworm.com/index.php?rid=3273503&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F35065372m3t1q25q%2F Abstract  Mammographic density is strongly related to increased breast cancer risk. Accumulating evidence indicates that a role for the IGF-pathway in mammographic density and breast cancer development. Here, we investigate whether common genetic variation in this pathway influences insulin-like growth factor-I (IGF-I) levels and mammographic density. In 1,916 premenopausal women within the Prospect-EPIC cohort, we examined associations of 14 haplotype tagging SNPs in the ALS, IGFBP1, and IGFBP3 genes with IGF-I circulating levels and mammographic density. In 657 women, who became postmenopausal during follow-up, we investigated how these SNPs were related with the decrease in density over menopause. Linear regression models were used for statistical analysis. None of the A... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3273503 Sun, 14 Feb 2010 06:51:42 +0100 3273503 Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells http://www.medworm.com/index.php?rid=3273504&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5375kl1477500452%2F Abstract  Studies were performed to determine the influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to Adriamycin (doxorubicin) in four human breast tumor cell lines and one murine breast tumor line. Sildenafil did not interfere with the effectiveness of Adriamycin in any of the cell lines tested. Sildenafil also failed to protect MDA-MB231 cells against the cytotoxicity of cisplatin, taxol or camptothecin. Sildenafil enhanced sensitivity to Adriamycin markedly in the p53 mutant MDA-MB231 and p53 null MCF-7/E6 cells and moderately in the MCF-7/caspase 3 and 4T1 cell lines. In the MDA-MB231 cells, sildenafil increased the extent of DNA damage induced by Adriamycin as well as the extent of apoptotic cell death. Sildenafil did not influence sensitivity... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3273504 Sat, 13 Feb 2010 06:49:33 +0100 3273504 Increased estrogen sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1(17β-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients http://www.medworm.com/index.php?rid=3270399&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F34t6672706804566%2F Abstract  Aromatase inhibitors (AIs) are considered the gold standard for endocrine therapy of estrogen receptor (ER) positive postmenopausal breast cancer patients. The therapy may enhance therapeutic response and stabilize disease but resistance and disease progression inevitably occur in the patients. These are considered at least partly due to an emergence of alternative intratumoral estrogen production pathways. Therefore, in this study we evaluated effects of exemestane (EXE) upon the enzymes involved in intratumoral estrogen production including estrogen sulfatase (STS), 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), and estrogen sulfotransferase (EST) and correlated the findings with therapeutic responses including Ki67 labeling index (Ki67). 116 postmenopausa... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3270399 Fri, 12 Feb 2010 07:12:02 +0100 3270399 Comparative disease pattern of a patient with a novel BRCA2 truncation and knockout models for BRCA2 http://www.medworm.com/index.php?rid=3270401&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F27h3x82840262606%2F We report a novel germline 490delCT mutation in BRCA2 gene, detected in a 38-year-old woman with breast cancer. The mutation originates a premature stop at codon 99, leading to a truncated protein, and has not been documented in any published report to the best of our knowledge. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s10549-010-0776-4Authors Josefa Salgado, University Clinic of Navarra (CUN) Clinical Genetics Unit Avda. Pio XII, 36 31008 Pamplona Navarra SpainCristina Gutiérrez, University Clinic of Navarra (CUN) Clinical Genetics Unit Avda. Pio XII, 36 31008 Pamplona Navarra SpainCarmen Gil, University Clinic of Navarra (CUN) Clinical Genetics Unit Avda. Pio XII, 36 31008 Pamplona Navarra SpainMaitane Robles, University Clinic of Navarra (CUN) Clinical Genetic... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3270401 Fri, 12 Feb 2010 07:12:01 +0100 3270401 The association between HSD17B1 Ser312Gly polymorphism and breast cancer risk: a meta-analysis including 31,053 subjects http://www.medworm.com/index.php?rid=3270400&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fax221r542r1240m2%2F In conclusion, this study suggests that HSD17B1 312Gly allele may be a protective factor for breast cancer development in Caucasians. However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0784-4Authors Lei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaLi-huan Cao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaLi-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai Pe... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3270400 Fri, 12 Feb 2010 07:12:01 +0100 3270400 Sustained lower rates of breast cancer incidence in France in 2007 http://www.medworm.com/index.php?rid=3270402&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq311677r0044472g%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-010-0779-1Authors Brigitte Séradour, ARCADES (Association pour la recherche et le dépistage des cancers du sein, du col de l’utérus et des cancers colorectaux) Parc Mure Bat.A, 16 boulevard des Aciéries 13395 Marseille Cedex 10 FranceHubert Allemand, CNAMTS (Caisse Nationale d’Assurance Maladie des Travailleurs Salariés) 50 avenue du Pr André Lemierre 75983 Paris Cedex 20 FranceAlain Weill, CNAMTS (Caisse Nationale d’Assurance Maladie des Travailleurs Salariés) 50 avenue du Pr André Lemierre 75983 Paris Cedex 20 FrancePhilippe Ricordeau, CNAMTS (Caisse Nationale d’Assurance Maladie des Travailleurs Salariés) 50 avenue du Pr André Lemierre 75983 Paris Cedex 20 France Journal Breast Cance... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3270402 Fri, 12 Feb 2010 07:11:59 +0100 3270402 Extremely low-frequency electromagnetic fields exposure and female breast cancer risk: a meta-analysis based on 24,338 cases and 60,628 controls http://www.medworm.com/index.php?rid=3263850&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk1454363t58p25nu%2F In conclusion, this meta-analysis suggests that ELF-EMF exposure has no association with the susceptibility of female breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0782-6Authors Chunhai Chen, Third Military Medical University Faculty of Preventive Medicine, Department of Occupational Health, Key Laboratory of Electromagnetic Radiation Protection Chongqing 400038 ChinaXiangyu Ma, Third Military Medical University Faculty of Preventive Medicine, Department of Epidemiology Chongqing 400038 ChinaMin Zhong, Third Military Medical University Faculty of Preventive Medicine, Department of Occupational Health, Key Laboratory of Electromagnetic Radiation Protection Chongqing 400038 ChinaZhengping Yu, Third Military Medical University Faculty of Preventi... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3263850 Tue, 09 Feb 2010 17:46:18 +0100 3263850 MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls http://www.medworm.com/index.php?rid=3255808&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuq4262jh1mv728k0%2F In conclusion, this meta-analysis suggests that the MTHFR T allele is a low-penetrant risk factor for developing breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0783-5Authors Jian Zhang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLi-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaZhong-Hua Wang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaXiang-Hua Wu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaXiao-Jian Liu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaBi-Yun Wang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaXi-Chun Hu, Fudan Univer... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255808 Mon, 08 Feb 2010 17:32:24 +0100 3255808 NBS1 8360G > C polymorphism is associated with breast cancer risk: a meta-analysis http://www.medworm.com/index.php?rid=3255807&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4337020w2t162627%2F Abstract  NBS1 gene plays an important role in DNA repair. Many epidemiological studies have investigated the association between NBS1 8360G > C polymorphism and breast cancer, however, the results are still controversial. Therefore, we performed a meta-analysis of 10 case–control studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. The results showed NBS1 8360G > C polymorphism contributed to breast risk in overall populations (for CC vs. GG: OR = 0.75, 95% CI = 0.74–0.98, P = 0.13 for heterogeneity; for the recessive model CC vs. GG/CG: OR = 0.88, 95% CI = 0.77–1.00, P = 0.44 for heterogeneity). In subgroup analysis... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255807 Mon, 08 Feb 2010 17:32:24 +0100 3255807 Lack of association between MnSOD Val16Ala polymorphism and breast cancer risk: a meta-analysis involving 58,448 subjects http://www.medworm.com/index.php?rid=3255809&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3x3718744rpl6287%2F In conclusion, this meta-analysis suggests that the MnSOD Val16Ala polymorphism may be not associated with breast cancer development. However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0777-3Authors Li-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaChen Mao, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou ChinaBo Chen, Nanjing Medical University Department of Ge... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255809 Mon, 08 Feb 2010 17:32:23 +0100 3255809 Worse prognosis of metaplastic breast cancer patients than other patients with triple-negative breast cancer http://www.medworm.com/index.php?rid=3255811&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr71u88775n312314%2F Abstract  The present study was designed to assess the clinical characteristics and outcomes of metaplastic breast cancer (MBC) compared to general invasive ductal carcinoma (IDC) and the triple-negative subtype (TN-IDC). The study population included 35 MBC and 2,839 IDC patients, including 473 TN-IDC diagnoses, from the National Cancer Center, Korea between 2001 and 2008. The clinicopathological characteristics and clinical outcomes were retrospectively reviewed. Mean age of patients was 47.4 years for the MBC group and 48.3 years for the IDC group. The MBC patients presented with a larger tumor size (≥T2, 74.3% vs. 38.8%, P < 0.001), more distant metastasis at the first diagnosis (8.6% vs. 2.0%, P = 0.04), higher histologic grade (grade ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255811 Mon, 08 Feb 2010 17:32:22 +0100 3255811 TGFB1 L10P polymorphism is associated with breast cancer susceptibility: evidence from a meta-analysis involving 47,817 subjects http://www.medworm.com/index.php?rid=3255810&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2t1321l5522988n1%2F In conclusion, this meta-analysis suggests that the TGFB1 10P allele may be a low-penetrant risk factor for developing breast cancer. However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0781-7Authors Li-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaChen Mao, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou ChinaBo Chen, Nanjing Medical University Department of Ge... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255810 Mon, 08 Feb 2010 17:32:22 +0100 3255810 Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the breast cancer family registry http://www.medworm.com/index.php?rid=3255812&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fml01x13545277qk0%2F Abstract  Few studies have considered the joint association of body mass index (BMI) and physical activity, two modifiable factors, with all-cause mortality after breast cancer diagnosis. Women diagnosed with invasive breast cancer (n = 4,153) between 1991 and 2000 were enrolled in the Breast Cancer Family Registry through population-based sampling in Northern California, USA; Ontario, Canada; and Melbourne and Sydney, Australia. During a median follow-up of 7.8 years, 725 deaths occurred. Baseline questionnaires assessed moderate and vigorous recreational physical activity and BMI prior to diagnosis. Associations with all-cause mortality were assessed using Cox proportional hazards regression, adjusting for established prognostic factors. Compared with no phy... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255812 Sat, 06 Feb 2010 18:06:15 +0100 3255812 ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer http://www.medworm.com/index.php?rid=3255813&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd1x054vk18833x4n%2F Conclusion: ICG fluorescence imaging is a new method for SLN biopsy in breast cancer with acceptable sensitivity and specificity comparable to conventional methods. One advantage of this technique is that it allows transcutaneous visualization of lymphatic vessels and intraoperative lymph node detection without radioisotope. Content Type Journal ArticleCategory Clinical trialDOI 10.1007/s10549-010-0760-zAuthors Christoph Hirche, Robert-Rössle-Klinik, Helios Hospital Berlin-Buch, CCB Department of General Surgery and Surgical Oncology 13125 Berlin GermanyDawid Murawa, Robert-Rössle-Klinik, Helios Hospital Berlin-Buch, CCB Department of General Surgery and Surgical Oncology 13125 Berlin GermanyZarah Mohr, Robert-Rössle-Klinik, Helios Hospital Berlin-Buch, CCB Department of General ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255813 Sat, 06 Feb 2010 18:06:14 +0100 3255813 The use of FDG-PET in assessing axillary lymph node status in breast cancer: a systematic review and meta-analysis of the literature http://www.medworm.com/index.php?rid=3255815&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv616248l9w597m42%2F Abstract  Axillary lymph node status is the most powerful prognostic indicator in patients with breast cancer. FDG-PET has been suggested as a non-invasive method of staging the axilla. The aim of this study was to review and aggregate all studies that measured the performance of FDG-PET in patients with breast cancer, using surgically obtained axillary histology as a reference, in a meta-analysis. A systematic review of the literature was performed and data extracted from all eligible studies. These were then analysed using meta-analysis software and summary receiver operating characteristic (SROC) curves were plotted for the aggregate data. The data was then tested to determine which parameters impacted on the sensitivity and specificity of the studies. Sensitivities rang... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255815 Sat, 06 Feb 2010 18:06:13 +0100 3255815 Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women’s Health Study http://www.medworm.com/index.php?rid=3255814&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5p2k53l1h763245k%2F Abstract  Two single nucleotide polymorphisms (SNPs), rs4415084, and rs10941679 on chromosome 5p12 were associated with risk of breast cancer in a recent genome-wide association study (GWAS) of women of European ancestry. Both SNPs are located in a large high-LD region and the causal variant(s) are still unknown. We conducted a nested case–control study in a cohort of African American women to replicate and narrow the region carrying the causal variant(s). We evaluated 14 tagging SNPs in a 98 kb LD block surrounding the index SNPs in 886 breast cancer cases and 1,089 controls from the Black Women’s Health Study. We used the Cochran–Armitage trend test to assess association with breast cancer risk. Odds ratios were derived from logistic regression analyses adjuste... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3255814 Sat, 06 Feb 2010 18:06:13 +0100 3255814 Quality of life among women recently diagnosed with invasive breast cancer: the Pathways Study http://www.medworm.com/index.php?rid=3247898&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh675410t15531075%2F We describe QOL among 950 women recently diagnosed with invasive breast cancer. Starting in January 2006, we invited women aged ≥21 years who were diagnosed with first primary invasive breast cancer within Kaiser Permanente Northern California (KPNC) to enroll in the Pathways Study, a prospective study of breast cancer survivorship. QOL was measured using the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B), along with sociodemographic and social support information. Clinical characteristics were obtained from the KPNC cancer registry and electronic medical record. We used multivariable linear regression models to identify factors associated with QOL scores calculated from the FACT-B. The mean age ± SD of the sample was 59.6 years (±11.9 yea... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3247898 Fri, 05 Feb 2010 18:17:32 +0100 3247898 Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells http://www.medworm.com/index.php?rid=3247899&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F292207l8g6072085%2F Abstract  Rapamycin and its analogues inhibit mTOR, which leads to decreased protein synthesis and decreased cancer cell proliferation in many experimental systems. Adenosine 5′- monophosphate-activated protein kinase (AMPK) activators such as metformin have similar actions, in keeping with the TSC2/1 pathway linking activation of AMPK to inhibition of mTOR. As mTOR inhibition by rapamycin is associated with attenuation of negative feedback to IRS-1, rapamycin is known to increase activation of AKT, which may reduce its anti-neoplastic activity. We observed that metformin exposure decreases AKT activation, an action opposite to that of rapamycin. We show that metformin (but not rapamycin) exposure leads to increased phosphorylation of IRS-1 at Ser789, a site previously rep... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3247899 Thu, 04 Feb 2010 18:13:44 +0100 3247899 Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer http://www.medworm.com/index.php?rid=3247900&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh755663814845013%2F Abstract  Given the greatly elevated risks of contralateral breast cancer (CBC) observed in breast cancer patients who carry mutations in BRCA1 and BRCA2, it is critical to determine the effectiveness of standard adjuvant therapies in preventing CBC in mutation carriers. The WECARE study is a matched, case–control study of 708 women with CBC as cases and 1,399 women with unilateral breast cancer (UBC) as controls, including 181 BRCA1/BRCA2 mutation carriers. Interviews and medical record reviews provided detailed information on risk factors and breast cancer therapy. All study participants were screened for BRCA1 and BRCA2 mutations using denaturing high-performance liquid chromatography (DHPLC) to detect genetic variants in the coding and flanking regions of the genes. Co... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3247900 Thu, 04 Feb 2010 18:13:43 +0100 3247900 Screening for genomic rearrangements in BRCA1 and BRCA2 genes in Czech high-risk breast/ovarian cancer patients: high proportion of population specific alterations in BRCA1 gene http://www.medworm.com/index.php?rid=3247901&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg53r5861631626mx%2F Abstract  Large genomic rearrangements (LGR) represent substantial proportion of pathogenic mutations in the BRCA1 gene, whereas the frequency of rearrangements in the BRCA2 gene is low in many populations. We screened for LGRs in BRCA1 and BRCA2 genes by multiplex ligation-dependent probe amplification (MLPA) in 521 unrelated patients negative for BRCA1/2 point mutations selected from 655 Czech high-risk breast and/or ovarian cancer patients. Besides long range PCR, a chromosome 17-specific oligonucleotide-based array comparative genomic hybridization (aCGH) was used for accurate location of deletions. We identified 14 patients carrying 8 different LGRs in BRCA1 that accounted for 12.3% of all pathogenic BRCA1 mutations. No LGRs were detected in the BRCA2 gene. In a subgroup o... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3247901 Thu, 04 Feb 2010 18:13:40 +0100 3247901 BRCA2 N372H polymorphism and breast cancer susceptibility: a meta-analysis involving 44,903 subjects http://www.medworm.com/index.php?rid=3247904&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp403585396610156%2F In conclusion, this meta-analysis suggests that the BRCA2 372H allele may be a low-penetrant risk factor for developing breast cancer. However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0767-5Authors Li-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaKai Xue, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaJian Zhang, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai Chi... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3247904 Thu, 04 Feb 2010 18:13:39 +0100 3247904 Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up http://www.medworm.com/index.php?rid=3247903&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy367h6411220141k%2F Abstract  Triple-negative breast cancer (TNB) has poor prognosis and moreover patients with TNB do not benefit from established targeted drugs with endocrine therapy or trastuzumab. The aim of the study was to analyze the prevalence of candidate biomarkers in tumors from patients with TNB. Tissue microarrays were prepared from primary tumors from premenopausal breast cancer patients (500/564) randomized to adjuvant tamoxifen or no adjuvant treatment. Immunohistochemical (IHC) staining included ER, PR, HER2, epidermal receptor growth factor (EGFR), vascular endothelial growth factor A (VEGF-A), and vascular endothelial growth factor receptor 2 (VEGFR2). EGFR and HER2 gene copy number was defined by fluorescence in situ hybridization (FISH). All patients were included in the ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3247903 Thu, 04 Feb 2010 18:13:39 +0100 3247903 Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls http://www.medworm.com/index.php?rid=3247902&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F08882r467m184605%2F Abstract  The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and breast cancer risk has been widely reported, but results were inconsistent and underpowered. To clarify the effects of MTHFR polymorphisms on the risk of breast cancer, an updated meta-analysis of all available studies relating C677T and/or A1298C polymorphisms of MTHFR gene to the risk of breast cancer was conducted. Eligible articles were identified by search of databases including MEDLINE, PubMed, Web of Science, EMBASE and Chinese Biomedical Literature database (CBM) for the period up to January 2010. Finally, a total of 41 studies with 16,480 cases and 22,388 controls were included, all for C677T polymorphism and 20 with 12,170 cases and 15,865 controls for A1298C polym... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3247902 Thu, 04 Feb 2010 18:13:39 +0100 3247902 Diagnostic value of vacuum-assisted breast biopsy for breast carcinoma: a meta-analysis and systematic review http://www.medworm.com/index.php?rid=3240886&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F354j513r67v8316g%2F Abstract  As mammography screening has its limitation in diagnosis in breast carcinoma, minimally invasive procedures offer a better option. We conducted a systematic review to establish the overall value of Vacuum-assisted breast biopsy (VAB) for the diagnosis of breast cancer. After a review and quality assessment of 21 studies, sensitivity, specificity and other measures of accuracy of VAB for evaluating breast lesions were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize overall accuracy. Underestimate rate of atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) were also calculated. The summary estimates for VAB in diagnosis of breast carcinoma were as follows: sensitivity, 0.981 (95% confidenc... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240886 Wed, 03 Feb 2010 17:58:00 +0100 3240886 Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer http://www.medworm.com/index.php?rid=3240888&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr129264022k60886%2F Abstract  In breast cancer, recent studies suggest that the value of HER2 for predicting response to anthracycline-based chemotherapy may be more likely related to the concomitant amplification of the TOP2A gene. Here, we study the association between HER2 or TOP2A status and response to anthracycline-based preoperative chemotherapy and explore the interaction between HER2 or TOP2A status and intense dose-dense (IDD) chemotherapy. HER2 and TOP2A gene alterations were quantified by fluorescence in situ hybridization in primary tumor core biopsies from 373 high-risk primary breast cancer patients (tumors ≥3 cm or inflammatory) that received an IDD or conventionally scheduled anthracycline-based preoperative chemotherapy. HER2 was amplified in 94/350 tumors (27%) of whi... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240888 Wed, 03 Feb 2010 17:57:58 +0100 3240888 Global breast cancer seasonality http://www.medworm.com/index.php?rid=3240887&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr2k7500576j752xj%2F Abstract  Human breast cancer incidence has seasonal patterns that seem to vary among global populations. The aggregate monthly frequency of breast cancer diagnosis was collected and examined for 2,921,714 breast cancer cases diagnosed across 64 global regions over spans from 2 to 53 years. Breast cancer is consistently diagnosed more often in spring and fall, both in the Northern and Southern Hemispheres, regardless of presumable menopausal status (≤50, >50). This seasonality is increasingly more prominent as population distance from the equator increases and this latitude dependence is most pronounced among women living in rural areas. Moreover, the overall annual incidence (2005–2006), per 100,000 population, of breast cancer increased as the latitude of popu... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240887 Wed, 03 Feb 2010 17:57:58 +0100 3240887 Depressive symptoms among young breast cancer survivors: the importance of reproductive concerns http://www.medworm.com/index.php?rid=3240890&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq212j26183p22902%2F This study investigates whether concerns about reproduction after breast cancer treatment were associated with long-term depressive symptoms. Participants include 131 women diagnosed with early-stage breast cancer at age 40 or younger participating in the Women’s Healthy Eating and Living (WHEL) Survivorship Study. Participants were enrolled an average of 1.5 years postdiagnosis and depressive symptoms were monitored 6 times throughout the average additional 10 year follow-up period. Detailed recall of reproductive concerns after treatment was collected an average of 12 years postdiagnosis. Multilevel regression was used to evaluate whether mean long-term depressive symptoms differed as a function of reproductive concerns and significant covariates. Multilevel regres... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240890 Wed, 03 Feb 2010 17:57:56 +0100 3240890 Population-based survival-cure analysis of ER-negative breast cancer http://www.medworm.com/index.php?rid=3240889&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F14681248553073xv%2F This study investigated the trends over time in age and stage specific population-based survival of estrogen receptor negative (ER−) breast cancer patients by examining the fraction of cured patients and the median survival time for uncured patients. Cause-specific survival data from the Surveillance, Epidemiology, and End Results program for cases diagnosed during 1992–1998 were used in mixed survival cure models to evaluate the cure fraction and the extension in survival for uncured patients. Survival trends were compared with adjuvant chemotherapy data available from an overlapping patterns-of-care study. For stage II N+ disease, the largest increase in cure fraction was 44–60% (P = 0.0257) for women aged ≥70 in contrast to a 7–8% point increase for women aged &... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240889 Wed, 03 Feb 2010 17:57:56 +0100 3240889 COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case–control studies http://www.medworm.com/index.php?rid=3240891&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyw281u246730g232%2F In conclusion, COMT Val158Met polymorphism may be a low-penetrant risk factor for breast cancer development in European population. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0759-5Authors Haixia Ding, The First Affiliated Hospital of Nanjing Medical University Department of Geriatrics 300 Guangzhou Road 210029 Nanjing ChinaYuanyuan Fu, Nanjing Medical University Dental Research Institute, School of Stomatology 210029 Nanjing ChinaWeixian Chen, The First Affiliated Hospital of Nanjing Medical University Department of Geriatrics 300 Guangzhou Road 210029 Nanjing ChinaZhanwei Wang, Nanjing Medical University Department of Epidemiology and Biostatistics 140 Hanzhong Road 210029 Nanjing China Journal Breast Cancer Research and TreatmentOnline ISSN 1573... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240891 Wed, 03 Feb 2010 17:57:55 +0100 3240891 Information from CTC measurements for metastatic breast cancer prognosis—we should do more than selecting an “optimal cut point” http://www.medworm.com/index.php?rid=3240893&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7552l662l16m1764%2F Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s10549-010-0762-xAuthors T. Fehm, University of Tübingen Department of Gyn./OB Calwer Str. 7 72076 Tübingen GermanyW. Sauerbrei, University Medical Center Freiburg Institute of Medical Biometry and Informatics 79104 Freiburg Germany Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240893 Wed, 03 Feb 2010 17:57:54 +0100 3240893 Mammographic density does not differ between unaffected BRCA1/2 mutation carriers and women at low-to-average risk of breast cancer http://www.medworm.com/index.php?rid=3240892&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff2p678q002231h04%2F Abstract  Elevated mammographic density (MD) is one of the strongest risk factors for sporadic breast cancer. Epidemiologic evidence suggests that MD is, in part, genetically determined; however, the relationship between MD and BRCA1/2 mutation status is equivocal. We compared MD in unaffected BRCA1/2 mutation carriers enrolled in the U.S. National Cancer Institute’s Clinical Genetics Branch’s Breast Imaging Study (n = 143) with women at low-to-average breast cancer risk enrolled in the same study (n = 29) or the NCI/National Naval Medical Center’s Susceptibility to Breast Cancer Study (n = 90). The latter were BRCA mutation-negative members of mutation-positive families or women with no prior breast cancer, a Pedigree Assessment Tool score &... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240892 Wed, 03 Feb 2010 17:57:54 +0100 3240892 Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers http://www.medworm.com/index.php?rid=3240894&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg756k7612n658m11%2F Abstract  The purpose of this article is to evaluate the prognostic value of androgen receptor (AR) expression in patients with estrogen receptor (ER)-positive breast cancer, treated with endocrine therapy, with or without the addition of chemotherapy. A consecutive series of 953 patients with ER-positive breast cancer, treated between 1998 and 2003, was selected. Repeated immunohistochemistry confirmed the expression of ER in the tumor of 938 patients. AR expression was measured by immunohistochemistry. The Kaplan–Meier method, logrank test and multivariate Cox models were used to explore the impact of AR expression on time to relapse (TTR) and disease specific survival (DSS) in all patients and in subgroups treated with chemo-endocrine therapy or endocrine therapy alone... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3240894 Tue, 02 Feb 2010 17:51:11 +0100 3240894 The association between ERCC2 Asp312Asn polymorphism and breast cancer risk: a meta-analysis involving 22,766 subjects http://www.medworm.com/index.php?rid=3232739&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5828jk1064534214%2F In conclusion, this meta-analysis provides an evidence that ERCC2 312Asn allele may have a protective effect for breast cancer development in Asians. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0754-xAuthors Lei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaLi-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai People’s Republic of ChinaLu Yu, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaZhen Yang, Fudan University Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sc... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3232739 Mon, 01 Feb 2010 18:07:13 +0100 3232739 XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects http://www.medworm.com/index.php?rid=3232740&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl42468v4g07h13q5%2F Abstract  Several common single-nucleotide polymorphisms (SNPs) within the XRCC2 gene have been identified as potential breast cancer susceptibility loci and a coding SNP in exon 3 (Arg188His, rs3218536) has been extensively studied, though the results were inconclusive. We, in this study, performed a more convincing and precise estimation of the relationship between Arg188His and breast cancer by meta-analyzing the currently available evidence from literature. A total of 16 studies involving 18,341 cases and 19,028 controls (37,369 subjects) were identified for meta-analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the codominant model, dominant model, and recessive model. When all the studies were pool... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3232740 Mon, 01 Feb 2010 18:07:12 +0100 3232740 Tai chi for breast cancer patients: a systematic review http://www.medworm.com/index.php?rid=3232741&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu6125gm6537k0942%2F The objective of this review was to assess the effectiveness of tai chi for supportive breast cancer care. Eleven databases were searched from inception through December 2009. Controlled trials testing tai chi in patients with breast cancer that assessed clinical outcome measures were considered. The selection of studies, data extraction, and validations were performed independently by two reviewers. Risk of bias was assessed using Cochrane criteria. Three randomized clinical trials (RCTs) and four non-randomized controlled clinical trials (CCTs) met our inclusion criteria. The three RCTs tested the effects of tai chi on breast cancer care compared with walking exercise, psychological support therapy, or spiritual growth or standard health care and showed no significant differences b... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3232741 Mon, 01 Feb 2010 18:07:10 +0100 3232741 Associations between XPD polymorphisms and risk of breast cancer: a meta-analysis http://www.medworm.com/index.php?rid=3223956&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv781495377833p34%2F Abstract  Studies on polymorphisms of Xeroderma Pigmentosum Group D Protein (XPD) and breast cancer risk are inconclusive. To elucidate the role of XPD genotypes, all available studies were considered in this meta-analysis. The study provided 11,362/10,622 cases/controls for XPD K751Q and 9010/9873 cases/controls for XPD D312N, respectively. Overall, no apparent effects of 751Q allele compared to 751K on breast cancer risk was found in all subjects [RE OR = 1.04, 95% confidence interval (CI) (0.97–1.10), P = 0.28]. Insignificant effects were also found under other genetic contrasts (homologous contrast, dominant model, and recessive model). However, the 751Q allele showed significantly increased risk in Caucasians [FE OR = 1.05, 95% CI (1.00–... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3223956 Thu, 28 Jan 2010 18:03:15 +0100 3223956 Methionine synthase A2756G polymorphism and breast cancer risk: a meta-analysis involving 18,953 subjects http://www.medworm.com/index.php?rid=3223957&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcwq000704428354l%2F Abstract  The A2756G polymorphism in the methionine synthase (MTR) gene has been implicated in breast cancer risk. However, the published findings are inconsistent. We therefore performed a meta-analysis to investigate this relationship. Eleven published case–control studies, including 8,438 breast cancer cases and 10,515 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Overall, no significant associations between the MTR A2756G polymorphism and breast cancer risk were found for GG versus AA (OR = 0.98, 95% CI: 0.84–1.15), AG versus AA (OR = 0.95, 95% CI: 0.89–1.01), GG/AG versus AA (OR = 0.95, 95% CI = 0.89–1.01), and GG versus AG/AA (OR =&... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3223957 Thu, 28 Jan 2010 18:03:13 +0100 3223957 Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer http://www.medworm.com/index.php?rid=3223959&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm474844203727894%2F This study investigated the potential utility of circulating free DNA (cfDNA) as a source for PIK3CA mutation detection in patients with breast cancer. cfDNA extracted (QIAamp Virus spin kit) from blood and matched archival tumour from 46 patients with metastatic breast cancer and 30 patients with localised, operable breast cancer was assessed for hotspot PIK3CA mutations using Amplification Refractory Mutation System (ARMS™) allele-specific PCR and Scorpion probes. PIK3CA mutations were detected in 13/46 (28%) plasma-derived and 10/46 (21%) serum-derived cfDNA samples from metastatic breast cancer patients. In 41 cases with matched tumour and plasma-derived cfDNA data, concordance (same mutation status in plasma and tumour) was 95%. Where a PIK3CA mutation was present in tumour, th... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3223959 Wed, 27 Jan 2010 20:35:30 +0100 3223959 Combinatorial biomarker expression in breast cancer http://www.medworm.com/index.php?rid=3223958&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F60768353575m24vk%2F Abstract  Current clinical management of breast cancer relies on the availability of robust clinicopathological variables and few well-defined biological markers. Recent microarray-based expression profiling studies have emphasised the importance of the molecular portraits of breast cancer and the possibility of classifying breast cancer into biologically and molecularly distinct groups. Subsequent large scale immunohistochemical studies have demonstrated that the added value of studying the molecular biomarker expression in combination rather than individually. Oestrogen (ER) and progesterone (PR) receptors and HER2 are currently used in routine pathological assessment of breast cancer. Additional biomarkers such as proliferation markers and ‘basal’ markers are likely ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3223958 Wed, 27 Jan 2010 20:35:30 +0100 3223958 Diagnostic work-up of contralateral breast cancers has not improved over calendar period http://www.medworm.com/index.php?rid=3223960&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd0873l124x3811j6%2F This study aims to investigate if the diagnostic work-up of breast cancer patients has improved over the last 25 years and resulted in earlier diagnoses of CBC. Two population-based cohorts were used; all CBCs in Sweden 1976–2004 (n: 2932), and all CBCs in Stockholm, Sweden, 1976–2005 (n: 626), both cohorts with a maximum of 3 years between the two cancers. Synchronous CBC was defined as two cancers <3 months apart, the remainder was defined as metachronous CBC. We calculated the odds ratio of being diagnosed synchronously, relative to metachronously, using logistic regression, adjusting for whether the second cancer was detected through clinical work-up or not. The odds of synchronous CBC were significantly increased: 1.27 (95% CI, 1.13–1.42) per 5-year period, com... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3223960 Wed, 27 Jan 2010 20:35:29 +0100 3223960 Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes http://www.medworm.com/index.php?rid=3205696&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr213451k70641763%2F Abstract  Protein kinase C betaII (PKCβII) represents a novel potential target for anticancer therapies in breast cancer. In order to identify patient subgroups which might benefit from PKC-targeting therapies, we investigated the expression of PKCβII in human breast cancer cell lines and in a tissue microarray (TMA). We first screened breast cancer cell line representatives of breast cancer subtypes for PKCβII expression at the mRNA and at the protein levels. We analyzed a TMA comprising of tumors from 438 patients with a median followup of 15.4 years for PKCβII expression by immunohistochemistry along with other prognostic factors in breast cancer. Among a panel of human breast cancer cell lines, only MDA-MB-436, a triple negative basal cell line, showed overexpr... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3205696 Sat, 23 Jan 2010 07:45:44 +0100 3205696 Adjuvant therapy of triple negative breast cancer http://www.medworm.com/index.php?rid=3205698&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86h23428r7331h61%2F Abstract  Patients with the triple negative subtype of breast cancer have an overall poor outcome, with earlier relapses, distinct patterns of metastases, and lack of specific targets for treatment selection. Classification of these tumors has begun to be modified by inclusion of immunohistochemistry for various markers, and gene profiling. Further characterization of this subtype of breast cancer may aid in the identification of new targeted therapies. Anthracyclines and taxanes remain the standard of care in the adjuvant setting. However, novel anti-angiogenesis, anti-tubulin, and DNA repair agents are already under evaluation in (neo) adjuvant trials. Molecular characterization is being included in trials to identify optimal adjuvant strategies. The aim of this manuscrip... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3205698 Fri, 22 Jan 2010 10:12:15 +0100 3205698 Erratum to: Editorial: Cost-effective analyses in Breast Cancer Research and Treatment http://www.medworm.com/index.php?rid=3205697&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0701811405328552%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s10549-010-0743-0Authors Marc E. Lippman, University of Miami Miller School of Medicine Department of Medicine Miami FL USAStephen Ethier, Karmanos Cancer Institute Breast Cancer Program Detroit MI USADaniel F. Hayes, University of Michigan Health System Department of Internal Medicine Ann Arbor MI USA Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3205697 Fri, 22 Jan 2010 10:12:15 +0100 3205697 Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall http://www.medworm.com/index.php?rid=3194921&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe36848mjn0w30151%2F Abstract  Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region. In total, 31 angiosarcomas developed at a median age of 71 years. The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949–1988 developed angiosarcomas in edematous arms (Stewart–Treves syndrome) after median 11 years, and 17 females treated by segm... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3194921 Tue, 19 Jan 2010 17:45:53 +0100 3194921 The contralateral synchronous breast carcinoma: a comparison of histology, localization, and magnetic resonance imaging characteristics with the primary index cancer http://www.medworm.com/index.php?rid=3194922&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwg4601p583579662%2F Abstract  Women with unilateral breast carcinoma reveal an increased risk of suffering from malignancies in the contralateral breast. There is a controversy about the existence of bilateral phenotypic similarities. The aim of this investigation was to compare histologic findings, magnetic resonance imaging (MRI) parameters, and tumor localizations of synchronous bilateral carcinomas. MRI revealed in 42 of 875 women (4.8%) with primary index carcinomas a contralateral malignancy. Twenty-two of the 42 contralateral carcinomas could only be detected by MRI, not by clinical examination, X-ray mammography, or ultrasonography. In 875 patients, MRI therefore identified 22 (2.5%) otherwise occult contralateral cancers. To evaluate bilateral MRI similarities, multiple dynamic and mo... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3194922 Tue, 19 Jan 2010 17:45:52 +0100 3194922 Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT) http://www.medworm.com/index.php?rid=3194923&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5v05984485gx117%2F Abstract  Bone marrow-derived mesenchymal stem cells (MSCs) are known to specifically migrate to and engraft at tumour sites. Understanding interactions between cancer cells and MSCs has become fundamental to determining whether MSC-tumour interactions should be harnessed for delivery of therapeutic agents or considered a target for intervention. Breast Cancer Cell lines (MDA-MB-231, T47D & SK-Br3) were cultured alone or on a monolayer of MSCs, and retrieved using epithelial specific magnetic beads. Alterations in expression of 90 genes associated with breast tumourigenicity were analysed using low-density array. Expression of markers of epithelial–mesenchymal transition (EMT) and array results were validated using RQ-PCR. Co-cultured cells were analysed for changes in pr... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3194923 Tue, 19 Jan 2010 17:45:51 +0100 3194923 The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway http://www.medworm.com/index.php?rid=3194925&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl335584407441387%2F Abstract  Members of the conserved small heat shock protein (sHSP) family, such as αB-crystallin and Hsp27, are constitutively expressed in diverse malignancies and have been linked to several hallmark features of cancer including apoptosis resistance. In contrast, the sHSP HspB2/MKBP, which shares an intergenic promoter with αB-crystallin, was discovered as a chaperone of the myotonic dystrophy protein kinase and has not been previously implicated in apoptosis regulation. Here we describe a new function for HspB2 as a novel inhibitor of apical caspase activation in the extrinsic apoptotic pathway. Specifically, we demonstrate that HspB2 is expressed in a subset of human breast cancer cell lines and that ectopic expression of HspB2 in breast cancer cells confers resistanc... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3194925 Tue, 19 Jan 2010 17:45:50 +0100 3194925 Discovery and verification of protein differences between Er positive/Her2/neu negative breast tumor tissue and matched adjacent normal breast tissue http://www.medworm.com/index.php?rid=3194924&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl776v72661m3hu25%2F This study was designed to quantify and identify differences in protein levels between tumor and adjacent normal breast tissue from the same breast in 18 women with stage I/II ER positive/Her2/neu negative invasive breast cancer. Eighteen separate difference gel electrophoresis (DIGE) gels were run (1 gel per patient). Relative quantification was based on DIGE analysis. After excision and tryptic digestion, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and peptide mass mapping were used to identify protein spots. Two hundred and forty-three spots were differentially abundant between normal and cancer tissues. Fifty spots were identified: 41 were over abundant and nine were less abundant in cancers than in normal breast tissue. Western blotting provided ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3194924 Tue, 19 Jan 2010 17:45:50 +0100 3194924 The association between TA-repeat polymorphism in the promoter region of UGT1A1 and breast cancer risk: a meta-analysis http://www.medworm.com/index.php?rid=3194926&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F461371553kl7254j%2F In conclusion, this meta-analysis suggests that UGT1A1 A(TA)7TAA allele is a potential risk factor for breast cancer in Caucasians. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0742-1Authors Lei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaLi-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai People’s Republic of ChinaLu Yu, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaZhen Yang, Fudan University Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sciences Shanghai Peo... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3194926 Tue, 19 Jan 2010 17:45:48 +0100 3194926 Socioeconomic disparities in the decline in invasive breast cancer incidence http://www.medworm.com/index.php?rid=3194927&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk0702w3um362026l%2F We examined the decline in breast cancer incidence according to county-level socioeconomic indicators using data from the Surveillance, Epidemiology and End Results (SEER) program. Since socioeconomic status is associated with mammography screening, we also examined the relation between incidence of ductal carcinoma in situ (DCIS; a strong marker of mammography utilization) and the decline in invasive breast cancer. The reduction in invasive breast cancer incidence between 1998–2001 and 2003–2006 in the SEER 9 registries was greatest among women living in counties with higher median household income (−16% change for ≥$85,000 vs. -4% for <$35,000; P trend < 0.01) and a higher percentage of adults aged 25 years or older with a bachelor’s degree (−13% ch... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3194927 Tue, 19 Jan 2010 17:45:47 +0100 3194927 IGFBP3 A-202C polymorphism and breast cancer susceptibility: a meta-analysis involving 33,557 cases and 45,254 controls http://www.medworm.com/index.php?rid=3190401&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy21022737834xl50%2F In conclusion, this meta-analysis suggests that the IGFBP3 C allele is a low-penetrant risk factor for developing breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0739-9Authors Li-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaHui Yuan, Anhui Medical University Department of Epidemiology and Biostatistics, School of Public Health Anhui ChinaChen Mao, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou ChinaBo Chen, Nanjing Medical University Department of Geriatrics, First Affiliated Hospital Nanjing ChinaPing Zhan, N... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3190401 Mon, 18 Jan 2010 18:48:54 +0100 3190401 No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis http://www.medworm.com/index.php?rid=3190402&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc2568310g3m55477%2F In conclusion, the present meta-analysis strongly suggests that +331G>A in the PgR gene is not associated with breast cancer risk. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0738-xAuthors Ke-Da Yu, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaAo-Xiang Chen, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaZhi-Ming Shao, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of China Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Br... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3190402 Fri, 15 Jan 2010 00:44:25 +0100 3190402 Medical comorbidities predict mortality in women with a history of early stage breast cancer http://www.medworm.com/index.php?rid=3190403&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4607112l74j43001%2F In conclusion, type 2 diabetes is associated with poor breast cancer prognosis. Given that 85% of deaths were caused by breast cancer, these findings suggest that multiple comorbidities may reduce the likelihood of surviving additional breast cancer events. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0732-3Authors Ruth E. Patterson, University of California Cancer Prevention and Control Program, Moores UCSD Cancer Center San Diego, La Jolla CA 92093-0901 USAShirley W. Flatt, University of California Cancer Prevention and Control Program, Moores UCSD Cancer Center San Diego, La Jolla CA 92093-0901 USANazmus Saquib, University of California Cancer Prevention and Control Program, Moores UCSD Cancer Center San Diego, La Jolla CA 92093-0901 USACheryl L. Rock, ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3190403 Fri, 15 Jan 2010 00:44:24 +0100 3190403 Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells http://www.medworm.com/index.php?rid=3168488&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd0n23331006414r8%2F Abstract  Electron paramagnetic resonance (EPR) imaging is an emerging modality that can detect and localize paramagnetic molecular probes (so-called spin probes) in vivo. We previously demonstrated that nitroxide spin probes can be encapsulated in liposomes at concentrations exceeding 100 mM, at which nitroxides exhibit a concentration-dependent quenching of their EPR signal that is analogous to the self-quenching of fluorescent molecules. Therefore, intact liposomes encapsulating high concentrations of nitroxides exhibit greatly attenuated EPR spectral signals, and endocytosis of such liposomes represents a cell-activated contrast-generating mechanism. After endocytosis, the encapsulated nitroxide is liberated and becomes greatly diluted in the intracellular milieu. ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168488 Mon, 11 Jan 2010 18:22:29 +0100 3168488 Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue http://www.medworm.com/index.php?rid=3168489&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5291524844350527%2F The objective of this study was to determine the effect of PDT, alone or in combination with previously administered systemic BPs, on the structural and mechanical integrity of both healthy and metastatically involved vertebrae. Human breast carcinoma cells (MT-1) were inoculated into athymic rats (day 0). At 14 days, a single PDT treatment was administered, with and without previous BP treatment at day 7. In addition to causing tumor necrosis in metastatically involved vertebrae, PDT significantly reduced bone loss, resulting in strengthening of the vertebrae compared to untreated controls. Combined treatment with BP + PDT further enhanced bone architecture and strength in both metastatically involved and healthy bone. Overall, the ability of PDT to both ablate malign... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168489 Mon, 11 Jan 2010 18:22:28 +0100 3168489 Practical prognostic index for patients with metastatic recurrent breast cancer: retrospective analysis of 2,322 patients from the GEICAM Spanish El Alamo Register http://www.medworm.com/index.php?rid=3168491&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm46j0w131tv8g15r%2F In conclusion, risk scores are extraordinarily valuable tools, highly recommendable in the clinical practice. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s10549-009-0687-4Authors Javier Puente, Hospital Clínico San Carlos Medical Oncology Department C/Martín Lagos s/n 28040 Madrid SpainSara López-Tarruella, Hospital Clínico San Carlos Medical Oncology Department C/Martín Lagos s/n 28040 Madrid SpainAmparo Ruiz, Instituto Valenciano de Oncologia Medical Oncology Department Valencia SpainAna Lluch, Hospital Clínico Medical Oncology Department Valencia SpainMiguel Pastor, Hospital La Fe Medical Oncology Department Valencia SpainEmilio Alba, Hospital Virgen de la Victoria Medical Oncology Department Malaga SpainJuan de la Haba, Hospital Reina Sofía Medical Oncology... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168491 Sun, 10 Jan 2010 06:45:40 +0100 3168491 Breast cancer screening recommendations: dynamic extrapolation of limited data http://www.medworm.com/index.php?rid=3168490&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7401r9775184327%2F Content Type Journal ArticleCategory Invited commentaryDOI 10.1007/s10549-009-0707-4Authors Colin Mooney, University Of Michigan Ann Arbor USASofia Merajver, University Of Michigan Ann Arbor USA Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168490 Sun, 10 Jan 2010 06:45:40 +0100 3168490 Outcome of axillary staging in early breast cancer: a meta-analysis http://www.medworm.com/index.php?rid=3168493&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F644u55473888u2j1%2F Abstract  Axillary lymph node dissection (ALND) is associated with significant morbidity, whilst sentinel node biopsy (SNB) has the potential to minimize complications in the management of breast cancer. The aim of this study was to systematically appraise the outcome of SNB when compared to ALND. A comprehensive search for published trials examining outcomes after SNB for breast cancer was performed using medline and cross-referencing available data. Each study was reviewed and data extracted. Primary outcomes were nodal positivity and surgery-related morbidity. A total of 9,608 patients were identified from trials comparing ALND and SNB. The overall rate of axillary lymph node positivity for those with no clinically palpable nodes was 28.8% for ALND and 27.6% for SNB (OR&... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168493 Fri, 08 Jan 2010 21:40:34 +0100 3168493 Bevacizumab in metastatic breast cancer: a meta-analysis of randomized controlled trials http://www.medworm.com/index.php?rid=3168492&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn1jr574274467480%2F Abstract:  Numerous studies have demonstrated that angiogenesis and in particular VEGF over-expression play an essential role in the progression and metastatic potential of breast cancer. Bevacizumab is a humanized recombinant monoclonal antibody that specifically blocks the binding of VEGF to high-affinity receptors and it has been recently used for the treatment of metastatic breast cancer. We conducted a meta-analysis to synthesize available evidence for use of bevacizumab in metastatic breast cancer patients. Systematic review and meta-analysis of available trials. Primary outcomes were overall survival, progression free survival (PFS) and objective response rate (ORR). Five trials were identified with 3,163 eligible patients. Combination of bevacizumab and chemotherapy... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168492 Fri, 08 Jan 2010 21:40:34 +0100 3168492 The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis http://www.medworm.com/index.php?rid=3168494&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F01hj5237u887r552%2F Abstract  It was reported that the functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase gene was associated with breast cancer risk; however, the published studies have inconsistent conclusions. To elucidate the effect of hOGG1 Ser326Cys on the susceptibility to breast cancer, all available studies were collected in this meta-analysis. We extracted the data from 10 case–control studies that were published in the PubMed database from 2003 to 2008 using the search phrases “human 8-oxoguanine DNA glycosylase, hOGG1, OGG1, OGG, polymorphism, genetic variation, and breast cancer.” This meta-analysis included 4,963 breast cancer cases and 4,776 control subjects. The results showed that individuals who carrying the hOGG1 326Cys allele in the additive m... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168494 Thu, 07 Jan 2010 22:22:54 +0100 3168494 Obesity and weight change in relation to breast cancer survival http://www.medworm.com/index.php?rid=3168495&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff768262450k14711%2F Abstract  The authors evaluated the prognostic effects of obesity and weight change after breast cancer diagnosis. A total of 5042 breast cancer patients aged 20–75 were identified through the population-based Shanghai Cancer Registry approximately 6 months after cancer diagnosis and recruited into the study between 2002 and 2006. Participants were followed by in-person interviews supplemented by record linkage with the Shanghai Vital Statistics Registry database. Anthropometric measurements were taken, and information on sociodemographic, clinical, and lifestyle factors was collected through in-person interviews. During the median follow-up of 46 months, 442 deaths and 534 relapses/breast cancer-specific deaths were documented. Women with body mass index (BMI) ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168495 Thu, 07 Jan 2010 22:22:53 +0100 3168495 Half of breast cancer patients discontinue tamoxifen and any endocrine treatment before the end of the recommended treatment period of 5 years: a population-based analysis http://www.medworm.com/index.php?rid=3168496&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F79p2663302510457%2F In conclusion, up to half of the breast cancer patients starting tamoxifen continued 5 years of endocrine treatment. Identification of patients at risk of discontinuation will assist in the development of interventions to improve treatment continuation comparable to that of patients included in clinical trials. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0724-3Authors Myrthe P. P. van Herk-Sukel, PHARMO Institute for Drug Outcomes Research P.O. Box 85222 3508 AE Utrecht The NetherlandsLonneke V. van de Poll-Franse, Comprehensive Cancer Center South Eindhoven Cancer Registry Eindhoven The NetherlandsAdri C. Voogd, Comprehensive Cancer Center South Eindhoven Cancer Registry Eindhoven The NetherlandsGrard A. P. Nieuwenhuijzen, Catharina Hospital Departm... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168496 Thu, 07 Jan 2010 22:22:52 +0100 3168496 Angiotensin converting enzyme inhibitors may be protective against cardiac complications following anthracycline chemotherapy http://www.medworm.com/index.php?rid=3168497&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6910324472241448%2F Abstract  Doxorubicin (DOX), despite causing cardiac toxicity, is an anthracycline chemotherapeutic agent that plays an important role in the treatment of breast cancer. Angiotensin-converting enzyme inhibitors (ACE-I) may protect against cardiac toxicity in patients receiving DOX chemotherapy. A total of 143 patients receiving DOX at the Masonic Comprehensive Cancer Clinic, University of Minnesota, who had two or more multigated blood pool imaging (MUGA) scans or echocardiograms performed between 2004 and 2007 were identified and reviewed. Patients with a 10% absolute drop in their ejection fraction (EF) or more to below 55% were identified and compared with those that did not have a 10% decline in EF. Impact of patient variables and the use of concurrent medications on EF... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3168497 Thu, 07 Jan 2010 22:22:51 +0100 3168497 Variants in DNA double-strand break repair genes and risk of familial breast cancer in a South American population http://www.medworm.com/index.php?rid=3154205&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg302535prp043791%2F Abstract  The double-strand break (DSB) DNA repair pathway has been implicated in breast cancer (BC). RAD51 and its paralogs XRCC3 and RAD51D play an important role in the repair of DSB through homologous recombination (HR). Some polymorphisms including XRCC3-Thr241Met, RAD51-135G>C, and RAD51D-E233G have been found to confer increased BC susceptibility. In order to detect novel mutations that may contribute to BC susceptibility, 150 patients belonging to 150 Chilean BRCA1/2-negative families were screened for mutations in XRCC3. No mutations were detected in the XRCC3 gene. In addition, using a case–control design we studied the XRCC3-Thr241Met, and RAD51D-E233G polymorphisms in 267 BC cases and 500 controls to evaluate their possible association with BC susceptibility. T... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154205 Wed, 06 Jan 2010 18:07:08 +0100 3154205 Pre-operative assessment enables early diagnosis and recovery of shoulder function in patients with breast cancer http://www.medworm.com/index.php?rid=3154208&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fph317x1hnp731718%2F Abstract  In order to determine the extent and time course of upper limb impairment and dysfunction in women being treated for breast cancer (BC), and followed prospectively, a novel physical therapy surveillance model post-treatment was used. Subjects included adult women with newly diagnosed, untreated, unilateral, Stage I to III BC, and normal physiological and biomechanical shoulder function. Subjects were excluded if they had a previous history of BC, or prior injury or surgery of the affected upper limb. Measurements included body weight, shoulder ranges of motion (ROM), manual muscle tests, pain levels, upper limb volume, and an upper limb disability questionnaire (ULDQ). Measurements were taken at baseline (pre-surgery), and 1, 3–6, and 12 months post-surgery... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154208 Wed, 06 Jan 2010 18:07:07 +0100 3154208 New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines http://www.medworm.com/index.php?rid=3154207&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy27222685557q526%2F Abstract  Numerous recent studies indicate that most anticancer effects of PPARγ agonists like thiazolidinediones are the result of PPARγ-independent pathways. These conclusions were obtained by several approaches including the use of thiazolidinedione derivatives like Δ2-Troglitazone (Δ2-TGZ) that does not activate PPARγ. Since biotinylation has been proposed as a mechanism able to increase the specificity of drug delivery to cancer cells which could express a high level of vitamin receptor, a biotinylated derivative of Δ2-TGZ (bΔ2-TGZ) has been synthetized. In the present article, we have studied the in vitro effects of this molecule on both hormone-dependent (MCF-7) and hormone-independent (MDA-MB-231) breast cancer cells. In both cell lines, bΔ2-TGZ was more eff... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154207 Wed, 06 Jan 2010 18:07:07 +0100 3154207 Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case–control studies http://www.medworm.com/index.php?rid=3154206&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0361274008215740%2F Abstract  The functional Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene has been implicated in breast cancer risk. However, the published findings are inconsistent. We therefore performed a meta-analysis to investigate this relationship. Eleven published case–control studies, including 6,804 breast cancer cases and 6,725 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Overall, no significant associations between the hOGG1 Ser326Cys polymorphism and breast cancer risk were found for Cys/Cys versus Ser/Ser (OR = 1.07, 95% CI: 0.94–1.20), Ser/Cys versus Ser/Ser (OR = 0.99, 95% CI: 0.91–1.07), Cys/Cys + Ser/Cys versus Ser/Ser (OR&... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154206 Wed, 06 Jan 2010 18:07:07 +0100 3154206 Concordance of HER2 in primary tumor and leptomeningeal metastases: now what? http://www.medworm.com/index.php?rid=3154210&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe47u235496727r76%2F Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s10549-009-0720-7Authors Nancy U. Lin, Dana-Farber Cancer Institute Department of Medical Oncology 44 Binney Street Boston MA 02115 USA Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154210 Wed, 06 Jan 2010 18:07:03 +0100 3154210 Lack of association of CYP1A2-164 A/C polymorphism with breast cancer susceptibility: a meta-analysis involving 17,600 subjects http://www.medworm.com/index.php?rid=3154209&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F76h2u2372x536t08%2F In conclusion, upto date, there is still no enough evidence to indicate the association of CYP1A2-164 A/C polymorphism and breast cancer development. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0731-4Authors Li-Xin Qiu, Fudan University Department of Medical Oncology, Cancer Hospital Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaChen Mao, Southern Medical University Department of Epidemiology, School of Public Health and Tropical Medicine Guangzhou ChinaKe-Da Yu, Fudan University Department of Oncology, Shanghai Medical College Shanghai ChinaPing Zhan, Nanjing Chest Hospital Department of Respiratory Medicine Nanjing ChinaBo Chen, Nanjing Medical University ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154209 Wed, 06 Jan 2010 18:07:03 +0100 3154209 A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer http://www.medworm.com/index.php?rid=3154211&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F63620l1109x31t23%2F In conclusion, oral administration of BZL101 was safe, well tolerated, and showed promising clinical evidence of anticancer activity in this heavily pretreated population of women with MBC. Content Type Journal ArticleCategory Clinical trialDOI 10.1007/s10549-009-0678-5Authors Alejandra T. Perez, Memorial Cancer Institute Hollywood FL USABanu Arun, University of Texas MD Anderson Cancer Center Houston TX USADebu Tripathy, University of Southern California Los Angeles CA USAMary A. Tagliaferri, Bionovo, Inc. 5858 Horton Street, Suite 400 Emeryville CA 94608 USAHeather S. Shaw, University of North Carolina Chapel Hill NC USAGretchen G. Kimmick, Duke University Medical Center Durham NC USAIsaac Cohen, Bionovo, Inc. 5858 Horton Street, Suite 400 Emeryville CA 94608 USAEmma Shtivelman, B... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154211 Wed, 06 Jan 2010 18:07:02 +0100 3154211 Estimation of natural history parameters of breast cancer based on non-randomized organized screening data: subsidiary analysis of effects of inter-screening interval, sensitivity, and attendance rate on reduction of advanced cancer http://www.medworm.com/index.php?rid=3154212&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv5w17x1137500002%2F Abstract  Estimating the natural history parameters of breast cancer not only elucidates the disease progression but also make contributions to assessing the impact of inter-screening interval, sensitivity, and attendance rate on reducing advanced breast cancer. We applied three-state and five-state Markov models to data on a two-yearly routine mammography screening in Finland between 1988 and 2000. The mean sojourn time (MST) was computed from estimated transition parameters. Computer simulation was implemented to examine the effect of inter-screening interval, sensitivity, and attendance rate on reducing advanced breast cancers. In three-state model, the MST was 2.02 years, and the sensitivity for detecting preclinical breast cancer was 84.83%. In five-state model, t... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154212 Wed, 06 Jan 2010 18:07:01 +0100 3154212 Three polymorphisms in cytochrome P450 1B1 (CYP1B1) gene and breast cancer risk: a meta-analysis http://www.medworm.com/index.php?rid=3154214&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuk7ju4175l5g7m66%2F In conclusion, this meta-analysis suggests that CYP1B1 Arg48Gly, Ala119Ser and Asn453Ser polymorphisms are not associated with breast cancer risk. Studies on Chinese populations are needed, to elucidate race-specific effects on East Asian populations, if any. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0728-zAuthors Konstantinos P. Economopoulos, National University of Athens School of Medicine Athens GreeceTheodoros N. Sergentanis, National University of Athens School of Medicine Athens Greece Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154214 Wed, 06 Jan 2010 18:07:00 +0100 3154214 The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells http://www.medworm.com/index.php?rid=3154213&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc7449n6633p25674%2F Abstract  Resistance to endocrine therapy agents has presented a clinical obstacle in the treatment of hormone-dependent breast cancer. Our laboratory has initiated a study of microRNA regulation of signaling pathways that may result in breast cancer progression on aromatase inhibitors (AI). Microarray analysis of hormone refractory cell lines identified 115 differentially regulated microRNAs, of which 49 microRNAs were believed to be hormone-responsive. A group of microRNAs were inversely expressed in the AI-resistant lines versus LTEDaro and tamoxifen-resistant. We focused our work on hsa-miR-128a which was hormone-responsive and selectively up-regulated in the letrozole-resistant cell lines. Human miR-128a was predicted to target the TGFβ signaling pathway and indeed se... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154213 Wed, 06 Jan 2010 18:07:00 +0100 3154213 Temporal trends in area socioeconomic disparities in breast-cancer incidence and mortality, 1988–2005 http://www.medworm.com/index.php?rid=3154216&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fklh4180672264126%2F Abstract  Since an overarching goal of Healthy People 2010 was to eliminate health disparities, we determined temporal trends in socioeconomic disparities in five breast-cancer indicators (in situ, stage I, lymph-node positive, and locally advanced breast-cancer incidence, and breast-cancer mortality) by county socioeconomic deprivation using 1988–2005 population-based breast-cancer data. Using 1988–2005 data from women aged 40 and older from 200 counties in the Surveillance, Epidemiology, and End Results program, we examined trends in temporal disparities in the five breast-cancer indicators across quartiles of county socioeconomic deprivation. County-level trends were summarized using the estimated annual percentage change. Observed county rates were smoothed using Ba... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154216 Wed, 06 Jan 2010 18:06:59 +0100 3154216 Synergistic activity of letrozole and sorafenib on breast cancer cells http://www.medworm.com/index.php?rid=3154215&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu711253016028378%2F In this study we demonstrated the preclinical therapeutic efficacy of combining the aromatase inhibitor letrozole with the multi-kinase inhibitor sorafenib in aromatase-expressing breast cancer cell lines. Treatment with letrozole reduced testosterone-driven cell proliferation, by inhibiting the synthesis of estrogens. Sorafenib inhibited cell proliferation in a concentration-dependent manner; this effect was not dependent on sorafenib-mediated inhibition of Raf1, but involved the down-regulation of mTORC1 and its targets p70S6K and 4E-binding protein 1 (4E-BP1). At concentrations of 5–10 μM the growth-inhibitory effect of sorafenib was associated with the induction of apoptosis, as indicated by release of cytochrome c and Apoptosis-Inducing Factor into the cytosol, activatio... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154215 Wed, 06 Jan 2010 18:06:59 +0100 3154215 Correlation between consanguineous marriages and age-standardized mortality rate due to breast cancer, an ecologic study http://www.medworm.com/index.php?rid=3154217&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4861q624t7785854%2F Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s10549-009-0711-8Authors Mostafa Saadat, Shiraz University Department of Biology, College of Sciences 71454 Shiraz IranIraj Saadat, Shiraz University Department of Biology, College of Sciences 71454 Shiraz Iran Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154217 Tue, 05 Jan 2010 17:01:36 +0100 3154217 17β-Estradiol enhances α5 integrin subunit gene expression through ERα–Sp1 interaction and reduces cell motility and invasion of ERα-positive breast cancer cells http://www.medworm.com/index.php?rid=3154219&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3464h8708m8063vk%2F Abstract  In breast tumors the expression of estrogen receptor alpha (ERα) is known to be associated with a more favorable prognosis. ERα expression has been reported to reduce the metastatic potential of breast cancer cells. Recently, we have observed that extracellular matrix proteins activate ERα and that both liganded and unliganded receptor modulate cell invasiveness acting at nuclear level. To explain the mechanisms by which ERα regulates cell adhesion, we have evaluated the expression of α5β1 integrin, prevalently expressed in stationary cells, in response to 17β-estradiol (E2). Here we show that E2/ERα increases the expression of integrin α5β1 through Sp1-mediated binding to a GC-rich region located upstream of an ERE half-site in the 5′ flanking region of... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154219 Tue, 05 Jan 2010 17:01:34 +0100 3154219 Erratum to: The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study http://www.medworm.com/index.php?rid=3154218&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbq4356413522u883%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s10549-009-0684-7Authors Felice A. Tager, College of Physicians and Surgeons, Columbia University Medical Center Behavioral Medicine Program, Department of Psychiatry 1150 St. Nicholas Ave, Suite 1-121 New York NY USAPaula S. McKinley, College of Physicians and Surgeons, Columbia University Medical Center Behavioral Medicine Program, Department of Psychiatry 1150 St. Nicholas Ave, Suite 1-121 New York NY USAFreya R. Schnabel, New York University Medical Center Department of Surgical Oncology New York NY USAMahmoud El-Tamer, Columbia University Medical Center Department of Surgical Oncology, College of Physicians and Surgeons New York NY USAYing Keun K. Cheung, Columbia University Medical Center Departments of Epidemiology and Bios... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154218 Tue, 05 Jan 2010 17:01:34 +0100 3154218 The fog hasn’t lifted on “chemobrain” yet: ongoing uncertainty regarding the effects of chemotherapy and breast cancer on cognition http://www.medworm.com/index.php?rid=3154221&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr531702311168077%2F Content Type Journal ArticleCategory Invited commentaryDOI 10.1007/s10549-009-0719-0Authors Janette Vardy, University of Sydney Sydney Cancer Centre Sydney AustraliaHaryana Dhillon, University of Sydney Centre For Medical Psychology and Evidence-based Medicine Sydney Australia Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154221 Tue, 05 Jan 2010 17:01:32 +0100 3154221 Orally administered Endoxifen is a new therapeutic agent for breast cancer http://www.medworm.com/index.php?rid=3154220&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F24wg417w52uh5300%2F Abstract  Endoxifen is the key active metabolite of Tamoxifen, a widely used breast cancer drug. Orally administered Tamoxifen, is extensively metabolized by cytochrome P450 (CYP) enzymes, namely CYP3A4 and CYP2D6, into active metabolites, especially Endoxifen. Due to genetic polymorphism of CYP2D6, significant numbers of women metabolize Tamoxifen to varying degree and may not receive the optimal benefit from Tamoxifen treatment. We show that oral administration of Endoxifen achieved the optimally effective systemic levels reliably, which may eliminate variability associated with Tamoxifen metabolism that leads to unpredictability in efficacy. Furthermore, use of Endoxifen may avoid a potential serious drug interaction found between Tamoxifen and commonly used selective se... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154220 Tue, 05 Jan 2010 17:01:32 +0100 3154220 No association between SOD2 Val16Ala polymorphism and breast cancer susceptibility: a meta-analysis based on 9,710 cases and 11,041 controls http://www.medworm.com/index.php?rid=3154223&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1846777878706778%2F Abstract  Breast cancer is the most common cancer in women worldwide, but its etiology is still unclear. It is believed that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential harmful oxidizing species to harmless metabolites. The association of SOD2 Val16Ala polymorphism and breast cancer risk has been widely reported, but results of previous studies were somewhat contradictory and underpowered. To overcome the limitations of individual study and to understand the real situation, we conducted a systematic review and meta-analysis toward the association between SOD2 Val16Ala polymorphism and breast cancer. Through retrieving MEDLINE, PubMed, Embase, and Web of Science, a tota... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154223 Tue, 05 Jan 2010 17:01:31 +0100 3154223 Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects http://www.medworm.com/index.php?rid=3154222&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F91532905888j800t%2F In conclusion, this meta-analysis provides strong evidence that CYP1A1 T3801C polymorphism is not associated with breast cancer risk. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0717-2Authors Lei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaXiaoJia Yu, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of ChinaLong Yu, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai People’s Republic of China Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Bre... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154222 Tue, 05 Jan 2010 17:01:31 +0100 3154222 Breast cancer survival in women of African descent living in the US and in the Caribbean: effect of place of birth http://www.medworm.com/index.php?rid=3154225&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp6476rmlg051q757%2F This study suggests that biological, behavioral, environmental, and clinical factors play a significant role in the observed difference in breast cancer outcome in women of Afro Caribbean descent. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0702-9Authors Emanuela Taioli, SUNY Downstate Medical Center 450 Clarkson Avenue Box 43 Brooklyn NY 11203-2098 USAAllison Attong-Rogers, University Hospital of Brooklyn SUNY Downstate Medical Center Cancer Registry 450 Clarkson Avenue Box 119 Brooklyn NY 11203-2098 USAPenelope Layne, Guyana Registry 82 Garnett St Cvill Georgetown GuyanaVeronica Roach, Dr Elizabeth Quamina National Cancer Registry of Trinidad and Tobago, Eric Williams Medical Sciences Complex Mt. Hope TrinidadCamille Ragin, SUNY Downstate Medical Center ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154225 Tue, 05 Jan 2010 17:01:29 +0100 3154225 Association between CYP19 polymorphisms and breast cancer risk: results from 10,592 cases and 11,720 controls http://www.medworm.com/index.php?rid=3154224&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy156j5g814825566%2F Abstract  The association of CYP19 gene polymorphisms with breast cancer has been widely reported, but results of previous studies were somewhat contradictory and underpowered. In order to overcome the limitations of individual study and to understand the real situation, we conducted a systematic review and meta-analysis including three CYP19 gene polymorphisms [R264C polymorphism, CYP19_630 3-bp del/Ins polymorphism, and CYP19_681 (TTTA)n polymorphisms]. A total of 22 studies with 10,592 cases and 11,720 controls were identified, and the results showed that R264C polymorphism was not associated with breast cancer risk in overall (T vs. C: OR = 1.061, 95% CI = 0.929–1.212) or race-based populations (T vs. C for Asian: OR = 1.169, 95% CI =... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154224 Tue, 05 Jan 2010 17:01:29 +0100 3154224 XRCC3 5′-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis http://www.medworm.com/index.php?rid=3154226&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmr1678851p571977%2F In conclusion, this meta-analysis suggests that the variant G allele of XRCC3 5′-UTR polymorphism is a low-penetrant risk factor for developing breast cancer, while the variant G allele of XRCC3 IVS5-14 polymorphism has a protective effect on breast cancer development. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0726-1Authors Li-Xin Qiu, Cancer Hospital, Fudan University Department of Medical Oncology Shanghai ChinaChen Mao, School of Public Health and Tropical Medicine, Southern Medical University Department of Epidemiology Guangzhou ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaKe-Da Yu, Shanghai Medical College, Fudan University Department of Oncology Shanghai ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3154226 Mon, 04 Jan 2010 18:23:10 +0100 3154226 The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion http://www.medworm.com/index.php?rid=3136186&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc84553843n4731wr%2F This study aims to elucidate the molecular mechanism for a tumorigenic and invasive potential of Gα12 and Gα13 in MCF10A human breast epithelial cells. Here, we report, for the first time, that Gα12 and Gα13 induce upregulation of matrix metalloproteinase (MMP)-2 leading to the invasive and migratory phenotypes in MCF10A cells. We further show that p53 is an important transcription factor for induction of MMP-2 transcriptional activation by Gα12/13. Gα12/13-induced MMP-2 upregulation, invasion, and migration are dependent on the activation of Ras, Rac1, MKK3/6, p38, and Akt. Using human breast tissue samples, we demonstrate that the expression levels of Gα12 and MMP-2 are strongly correlated with the pathogenically diagnosed cancer (P < 0.0001). Moreover, the express... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3136186 Thu, 31 Dec 2009 16:45:55 +0100 3136186 Factors influencing the association between CYP17 T34C polymorphism and the risk of breast cancer: meta-regression and subgroup analysis http://www.medworm.com/index.php?rid=3134323&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F956x42717g034n05%2F Abstract  A number of studies have been investigated the association between CYP17 T34C polymorphism and the risk of breast cancer; the results of these studies are inconsistent, however. This fact implies that the effect of CYP17 T34C polymorphism on susceptibility to breast cancer may be modified by other risk factors. In order to provide a more definitive conclusion, a full meta-analysis combining and summarizing 24 studies was first performed. Both traditional method and Bayesian approach were applied. Odds ratio was estimated using a dominant mode of inheritance after a biological justification for the choice of genetic model. The results of homogeneity analysis (H = 1.16, I 2 = 25.4%, and P = 0.127) suggested the presence of heterogeneity... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3134323 Wed, 30 Dec 2009 16:46:16 +0100 3134323 Lack of an association between a functional polymorphism in the interleukin-6 gene promoter and breast cancer risk: a meta-analysis involving 25,703 subjects http://www.medworm.com/index.php?rid=3134324&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8r48271487w21778%2F Abstract  The association between a single-nucleotide polymorphism (SNP) −174G > C (rs1800795) located in the IL-6 gene promoter and breast cancer risk is still controversial and ambiguous. We performed in this study a more precise estimation of the relationship by meta-analyzing the currently available evidence from literature. A total of 11 publications containing 12 studies including 10,137 cases and 15,566 controls were identified. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the codominant model, dominant model, and recessive model. When all the studies were pooled into the meta-analysis, there was no evidence showing a significant association between −174G > C and breas... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3134324 Wed, 30 Dec 2009 16:46:15 +0100 3134324 High levels of uPA and PAI-1 predict a good response to anthracyclines http://www.medworm.com/index.php?rid=3130565&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk13l0034j4kg8752%2F We report that the 3-year DFS in the CMF arm differed significantly: 87.1% for patients with low levels of markers versus 77.0% for patients with high levels of markers (P = 0.044, HR = 2.81, 95% CI = 0.98–8.04). On the other hand, the 3-year DFS in the anthracycline arm did not differ much between the two marker level subgroups: 85.2% for patients with low levels of markers versus 81.8% for patients with high levels of markers. Our observation points out that worse prognosis correlated to high uPA and PAI-1 levels can be reversed by treatment efficacy achieved through anthracycline-based chemotherapy. Based on this observation, we hypothesize that uPA/PAI-1 combination could be predictive for response to systemic therapy. Content Type Journal Articl... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3130565 Mon, 28 Dec 2009 19:27:34 +0100 3130565 Molecular predictors of efficacy of adjuvant weekly paclitaxel in early breast cancer http://www.medworm.com/index.php?rid=3125035&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft4j5hh0257855683%2F Abstract  Treatment with fluororacil, epirubicin, and cyclophosphamide followed by weekly paclitaxel (FEC-P) yielded superior disease-free survival than FEC in the adjuvant breast cancer trial GEICAM 9906. We evaluate molecular subtypes predictive of prognosis and paclitaxel response in this trial. Two molecular subtype classifications based on conventional immunohistochemical and fluorescent in situ hybridization determinations were used: #1: Four groups segregated according to the combination of hormone receptor (HR) and HER2 status; #2: Intrinsic subtype classification (Triple Negative (TN), HER2, Luminal B and Luminal A). Results: Both subtype classifications yielded prognostic and predictive information. HR +/HER2− patients (and Luminal A patients) had a significantl... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3125035 Sat, 26 Dec 2009 16:39:11 +0100 3125035 UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs http://www.medworm.com/index.php?rid=3125034&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft013lj426171040x%2F Abstract  Overexpression of MDR1 in breast cancer remains a major cause for the failure of chemotherapy. In the present report, we find UHRF1 plays an important role in inhibiting MDR1 promoter activity by directly binding to the MDR1 promoter. Knockdown of UHRF1 activates MDR1 promoter activity and expression, attenuates the binding of UHRF1 and HDAC1 to the MDR1 promoter. Overexpression of UHRF1 in NCI/ADR-RES cells can induce deacetylation of histones H3 and H4 on the MDR1 promoter, which is facilitated by recruitment of HDAC1 to the MDR1 promoter. Loss of histone acetylation is accompanied by loss of binding of the key transcription factor, MyoD, CBP and p300, locking in marked suppression of MDR1, increasing sensitivity of MDR cancer cells to cytotoxic drugs that are trans... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3125034 Sat, 26 Dec 2009 16:39:11 +0100 3125034 Tamoxifen sensitivity and estrogen receptor mRNA levels http://www.medworm.com/index.php?rid=3122749&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn3702173r467p633%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-009-0696-3Authors P. N. Span, Radboud University Nijmegen Medical Centre Department of Radiation Oncology 874 P.O. Box 9101 6500 Nijmegen The NetherlandsH. W. van Laarhoven, Radboud University Nijmegen Medical Centre Department of Medical Oncology Nijmegen The NetherlandsF. C. G. J. Sweep, Radboud University Nijmegen Medical Centre Department of Laboratory Medicine Nijmegen The Netherlands Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122749 Fri, 25 Dec 2009 00:21:53 +0100 3122749 Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109 http://www.medworm.com/index.php?rid=3122751&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd8561g1001511813%2F Abstract  Serine proteases have been implicated in many stages of cancer development, facilitating tumor cell growth, invasion, and metastasis, and naturally occurring serine protease inhibitors have shown promise as potential anticancer therapeutics. Optimal design of inhibitors as potential therapeutics requires the identification of the specific serine proteases involved in disease progression and the functional targets responsible for the tumor-promoting properties. Here, we use the HMT-3522 breast cancer progression series grown in 3D organotypic culture conditions to find that serine protease inhibitors cause morphological reversion of the malignant T4-2 cells, assessed by inhibition of proliferation and formation of acinar structures with polarization of basal marker... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122751 Fri, 25 Dec 2009 00:21:51 +0100 3122751 Effect of a switch of aromatase inhibitors on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer: the ATOLL (articular tolerance of letrozole) study http://www.medworm.com/index.php?rid=3122750&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm00k37303042t281%2F This study shows that in patients intolerant to one AI, switching to another agent allows a higher proportion of patients to continue the therapy and maximize hormonal adjuvant therapy and disease outcome benefits. Content Type Journal ArticleCategory Clinical trialDOI 10.1007/s10549-009-0692-7Authors Karine Briot, Paris Descartes University Rheumatology Department, Cochin Hospital, Rheumatology Department 27 rue Faubourg Saint Jacques 75014 Paris FranceMichèle Tubiana-Hulin, René Huguenin Institute St Cloud FranceLaurent Bastit, Frédéric Joliot Center Rouen FranceIoana Kloos, Novartis Rueil Malmaison FranceChristian Roux, Paris Descartes University Rheumatology Department, Cochin Hospital, Rheumatology Department 27 rue Faubourg Saint Jacques 75014 Paris France Journal Br... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122750 Fri, 25 Dec 2009 00:21:51 +0100 3122750 Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis http://www.medworm.com/index.php?rid=3122752&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv862p3440r031n31%2F In conclusion, this meta-analysis points to the A2455G G allele as a risk factor for breast cancer among Caucasian subjects. On the contrary, T3801C, T3205C, and C2453A status does not seem capable of modifying breast cancer risk. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0694-5Authors Theodoros N. Sergentanis, National University of Athens School of Medicine Athens GreeceKonstantinos P. Economopoulos, National University of Athens School of Medicine Athens Greece Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Breast Cancer Research and Treatment) Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122752 Fri, 25 Dec 2009 00:21:50 +0100 3122752 TNFα −308 G/A polymorphism is associated with breast cancer risk: a meta-analysis involving 10,184 cases and 12,911 controls http://www.medworm.com/index.php?rid=3122753&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc025v2q651851133%2F In conclusion, this meta-analysis suggests that the TNFα −308 G allele is a risk factor for developing breast cancer, especially for Caucasians. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0698-1Authors Fang Fang, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaLei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaXiao Jia Yu, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaLu Yu, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences Shanghai ChinaQi Wu, Fudan University Stat... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122753 Fri, 25 Dec 2009 00:21:49 +0100 3122753 Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis http://www.medworm.com/index.php?rid=3122754&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy473747x3u018435%2F In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer. There is a need for further large studies into the role of these polymorphisms (especially rs5277) and other potentially functional polymorphisms/haplotypes in the COX-2 gene as breast cancer risk modifiers. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0688-3Authors Ke-Da Yu, Fudan University Department of Oncology, Shanghai Medical College Shanghai People’s Republic of ChinaAo-Xiang Chen, Fudan University Department of Oncology, Shanghai Medical College Shanghai People’s Republic of ChinaChen Yang, Fudan University Department of Oncology, Sha... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122754 Thu, 24 Dec 2009 19:47:23 +0100 3122754 Is the breast-conserving treatment with radiotherapy appropriate in BRCA1/2 mutation carriers? Long-term results and review of the literature http://www.medworm.com/index.php?rid=3122755&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp556134k131j8613%2F Abstract  As tumours in BRCA1/2 mutation carriers might be more sensitive to radiation, we investigated after long-term follow-up whether mutation status influenced the rate of ipsilateral and contralateral breast cancers after breast-conserving treatment (BCT). BRCA1 and BRCA2 genes were screened for germline mutations in 131 patients with a family history of breast and/or ovarian cancer who had undergone BCT and radiotherapy. Patients were matched to 261 controls with sporadic breast cancer according to age at diagnosis and year of treatment. Controls were followed up for at least as long as the interval between diagnosis and genetic screening in familial cases. Rates of ipsilateral and contralateral cancer between groups were compared by the log-rank test. The BRCA1/2 muta... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122755 Thu, 24 Dec 2009 19:47:22 +0100 3122755 The functional promoter polymorphism (−842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger http://www.medworm.com/index.php?rid=3122756&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxu675v4727620376%2F In conclusion, the PIN1 polymorphisms may contribute to the etiology of sporadic breast cancer in non-Hispanic white women 55 years and younger. Further validation in large population-based studies is needed. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0682-9Authors Chan H. Han, The University of Texas M. D. Anderson Cancer Center Department of Epidemiology, Unit 1365 1515 Holcombe Blvd. Houston TX 77030 USAJiachun Lu, The University of Texas M. D. Anderson Cancer Center Department of Epidemiology, Unit 1365 1515 Holcombe Blvd. Houston TX 77030 USAQingyi Wei, The University of Texas M. D. Anderson Cancer Center Department of Epidemiology, Unit 1365 1515 Holcombe Blvd. Houston TX 77030 USAMelissa L. Bondy, The University of Texas M. D. Anderson Cancer... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122756 Thu, 24 Dec 2009 19:47:21 +0100 3122756 Role of endothelial progenitor cells in breast cancer angiogenesis: from fundamental research to clinical ramifications http://www.medworm.com/index.php?rid=3122757&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe76550634813x367%2F Abstract  Blood vessel formation (neovascularization) in tumors can occur through two mechanisms: angiogenesis and vasculogenesis. Angiogenesis results from proliferation and sprouting of existing blood vessels close to the tumor, while vasculogenesis is believed to arise from recruitment of circulating cells, largely derived from the bone marrow, and de novo clonal formation of blood vessels from these cells. Increasing evidence in animal models indicate that bone marrow-derived endothelial precursor cells (EPC) can contribute to tumor angiogenesis. This review aims to collate existing literature and provide an overview on the current knowledge of EPC involvement in breast cancer angiogenesis. We also discuss recent attempts to use EPC as biomarker and therapeutic target i... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122757 Thu, 24 Dec 2009 19:47:20 +0100 3122757 Lack of association between CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis of 22,090 cases and 28,498 controls http://www.medworm.com/index.php?rid=3122758&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm6006uq044hv1086%2F Abstract  Epidemiological studies have evaluated the association between CYP17 MspA1 polymorphism and breast cancer risk. However, the results remain conflicting rather than conclusive. To derive a more precise estimation of the relationship, we performed this meta-analysis. Systematic searches of the PubMed and Medline databases were performed. A total of 35 studies including 22,090 cases and 28,498 controls were identified. Genotype distributions of CYP17 in the controls of all studies were in agreement with Hardy–Weinberg equilibrium (HWE) except for three studies. When all 35 studies were pooled into the meta-analysis, there was no evidence for significant association between CYP17 MspA1 polymorphism and breast cancer risk (for A1/A2 vs. A1/A1: OR = 1.00, 95% ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3122758 Thu, 24 Dec 2009 19:47:18 +0100 3122758 No association between CYP1B1 Val432Leu polymorphism and breast cancer risk: a meta-analysis involving 40,303 subjects http://www.medworm.com/index.php?rid=3121218&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3u631265m540225%2F In conclusion, this meta-analysis provides strong evidence that CYP1B1 Val432Leu polymorphism is not associated with breast cancer risk. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0689-2Authors Lei Yao, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences 200433 Shanghai People’s Republic of ChinaFang Fang, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences 200433 Shanghai People’s Republic of ChinaQi Wu, Fudan University State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences 200433 Shanghai People’s Republic of ChinaYang Zhong, Fudan University Ministry of Education Key Laboratory for Biodiversity Sc... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3121218 Wed, 23 Dec 2009 22:55:46 +0100 3121218 Broad BRCA1 and BRCA2 mutational spectrum and high incidence of recurrent and novel mutations in the eastern Spain population http://www.medworm.com/index.php?rid=3121219&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F83748189r4q67258%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-009-0680-yAuthors Eva Esteban Cardeñosa, Hospital Universitario La Fe Laboratorio de Biología Molecular, Servicio de Biopatología Clínica, Escuela de Enfermería 7ª Planta Avda. Campanar 21 46009 Valencia SpainPascual Bolufer Gilabert, Hospital Universitario La Fe Laboratorio de Biología Molecular, Servicio de Biopatología Clínica, Escuela de Enfermería 7ª Planta Avda. Campanar 21 46009 Valencia SpainInmaculada de Juan Jimenez, Hospital Universitario La Fe Laboratorio de Biología Molecular, Servicio de Biopatología Clínica, Escuela de Enfermería 7ª Planta Avda. Campanar 21 46009 Valencia SpainSarai Palanca Suela, Hospital Universitario La Fe Laboratorio de Biología Molecular, Servicio de Biopato... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3121219 Wed, 23 Dec 2009 22:55:45 +0100 3121219 Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study http://www.medworm.com/index.php?rid=3116370&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F657543xu11g36115%2F We examined the association of dietary lignan intakes with survival in 1122 women with primary, incident, histologically confirmed breast cancer identified between 1996 and 2001, and with vital status determined through December 31, 2006. Diet in the 12–24 months before diagnosis was assessed with an extensive food frequency questionnaire, and potential confounders assessed from an extensive epidemiologic interview and abstracted clinical data. Lignan intake was calculated using published food composition data. Hazard ratios (HR), and 95% confidence intervals (CIs) for dietary lignan intakes with all cause, and breast cancer mortality were estimated using Cox proportional hazards adjusting for age, education, race, total energy intake, tumor stage, and body mass index. Of the ... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3116370 Mon, 21 Dec 2009 23:02:34 +0100 3116370 Gene amplification in ductal carcinoma in situ of the breast http://www.medworm.com/index.php?rid=3116369&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Feg0l36u5125k200m%2F Abstract  Multiple different biologically and clinically relevant genes are often amplified in invasive breast cancer, including HER2, ESR1, CCND1, and MYC. So far, little is known about their role in tumor progression. To investigate their significance for tumor invasion, we compared pure ductal carcinoma in situ (DCIS) and DCIS associated with invasive cancer with regard to the amplification of these genes. Fluorescence in situ hybridization (FISH) was performed on a tissue microarray containing samples from 130 pure DCIS and 159 DCIS associated with invasive breast cancer. Of the latter patients, we analyzed the intraductal and invasive components separately. In addition, lymph node metastases of 23 patients with invasive carcinoma were included. Amplification rates of p... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3116369 Mon, 21 Dec 2009 23:02:34 +0100 3116369 Are PALB2 mutations associated with increased risk of male breast cancer? http://www.medworm.com/index.php?rid=3108997&cid=s_33460_6_f&fid=33460&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx4v141261v14rg57%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10549-009-0673-xAuthors A. Sauty de Chalon, The University of Melbourne Genetic Epidemiology Laboratory, Department of Pathology VIC 3010 AustraliaZ. Teo, The University of Melbourne Genetic Epidemiology Laboratory, Department of Pathology VIC 3010 AustraliaD. J. Park, The University of Melbourne Genetic Epidemiology Laboratory, Department of Pathology VIC 3010 AustraliaF. A. Odefrey, The University of Melbourne Genetic Epidemiology Laboratory, Department of Pathology VIC 3010 AustraliakConFab, The Peter MacCallum Cancer Centre East Melbourne VIC AustraliaJ. L. Hopper, University of Melbourne Centre for Molecular, Environmental, Genetic and Analytic Epidemiology VIC AustraliaM. C. Southey, The University of Melbourne... Breast Cancer Research and Treatment journals http://www.medworm.com/rss/comments.php?id=3108997 Sat, 19 Dec 2009 16:45:20 +0100 3108997