MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Breast Cancer Research' source. Wed, 08 Feb 2012 08:41:16 +0100 http://www.medworm.com/index.php?rid=5666646&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F203 Cadherins are transmembrane receptors that function through calcium-dependent homophilic and heterophilic interactions that provide cell-cell contact and communication in many different organ systems. In the mammary gland only a few of the cadherins that make up this large superfamily of proteins have been characterized. Frequently in metastatic breast cancer, the genes for cadherins are epigenetically silenced, mutated, or regulated differently. During epithelial mesenchymal transition, cadherins that are expressed normally in the epithelial cells are down regulated, while cadherins expressed in the mesenchyme are up regulated. This process is known as cadherin switching, and its regulation can sometime facilitates the increase motility, invasiveness and proliferation that occurs in meta... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5666646 Wed, 08 Feb 2012 05:00:00 +0100 5666646 http://www.medworm.com/index.php?rid=5666645&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F204 Smad proteins are the key intermediates of TGF-beta-signaling during development and in tissue homeostasis. Pertubations in TGF-beta/Smad signaling have been implicated in cancer, and other diseases. In the cell nucleus Smad complexes trigger cell type- and context-specific transcriptional programs, thereby transmitting and integrating signals from a variety of ligands of the TGF-beta-superfamily and other stimuli in the cell micro-environment. The actual transcriptional and biological outcome of Smad activation critically depends on the genomic integrity and the modification state of genome and chromatin of the cell. The cytoplasmic and nuclear Smads can also modulate the activity of other signal transducers and enzymes such as microRNA processing factors. In the case of breast cancer the... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5666645 Wed, 08 Feb 2012 05:00:00 +0100 5666645 http://www.medworm.com/index.php?rid=5666650&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR23 Conclusions: Expression of CXCL12 by tumor cells results in increased macrophage and microvessel density and in vivo invasiveness. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5666650 Tue, 07 Feb 2012 05:00:00 +0100 5666650 http://www.medworm.com/index.php?rid=5666649&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR24 Conclusions: This is the first study to explore the contribution of germline CNVs to BRCA1/2 negative familial and early-onset breast cancer. The data suggest that rare CNVs may contribute to cancer predisposition in this small cohort of patients, and this trend needs to be confirmed in larger samples. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5666649 Tue, 07 Feb 2012 05:00:00 +0100 5666649 http://www.medworm.com/index.php?rid=5666648&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR25 Conclusions: Taken together, genetic risk factors and mammographic density offer moderate improvements to clinical risk factor models for predicting breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5666648 Tue, 07 Feb 2012 05:00:00 +0100 5666648 http://www.medworm.com/index.php?rid=5666647&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F301 PIK3CA mutations confer constitutive activation of PI3K, which initiates intracellular kinase signaling cascades that promote cell proliferation and survival. Recent studies by Meyer et al. and Liu et al. demonstrate that expression of the H1047R exon 20 mutant of PIK3CA in luminal mammary epithelial cells induces tumorigenesis, implying that PIK3CA mutations are an early event in breast cancer. PIK3CA-H1047R-initiated tumors exhibit variable dependence on the oncogene, and variable sensitivity to PI3K inhibition. Amplification of the oncogenes MYC and MET was observed in tumors which recurred following silencing of PIK3CA-H1047R, suggesting that these pathways represent mechanisms of escape from PI3K inhibition. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5666647 Tue, 07 Feb 2012 05:00:00 +0100 5666647 http://www.medworm.com/index.php?rid=5666651&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR22 Conclusion: Inhibiting PLK1 with siRNA or BI 2536 blocked growth of TNBCs including the CD44high/CD24-/low TIC subpopulation and mammosphere formation. Thus, PLK1 could be a potential therapeutic target for the treatment of TNBC as well as other subtypes of breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5666651 Mon, 06 Feb 2012 05:00:00 +0100 5666651 http://www.medworm.com/index.php?rid=5659309&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR21 IntroductionGlucocorticoids are widely prescribed drugs. In the human body, glucocorticoid is the main stress hormone, and controls a variety of physiological and cellular processes, including metabolism and immune response. It belongs to the same steroid superfamily as estrogens, which are known to play a role in breast cancer. However, the effect of glucocorticoid use on the risk of breast cancer is not clear. Methods: We conducted a case-control study using population-based medical databases from Northern Denmark (1.8 million inhabitants) to investigate the association between glucocorticoid prescriptions and breast cancer risk. The study included 9,488 incident breast cancer cases diagnosed between 1994 and 2008 and 94,876 population controls. We estimated the odds ratios (ORs) and 95%... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5659309 Fri, 03 Feb 2012 05:00:00 +0100 5659309 http://www.medworm.com/index.php?rid=5646911&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR20 Conclusions: P-I is safe and effective against breast cancer. Liposomal formulation enhances its efficacy; its effect is heavily dependent on the induction of oxidative stress and the suppression of the thioredoxin system. P-I merits further evaluation as an agent for the treatment of breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5646911 Tue, 31 Jan 2012 05:00:00 +0100 5646911 http://www.medworm.com/index.php?rid=5646910&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F104 The current understanding of the molecular biology of breast cancer presents an extremely complex portrait of the disease. Based on this knowledge, considerable efforts are being made to identify biomarkers that will predict the response to a specific treatment while minimizing the risk of unnecessary side effects. In breast cancer, the Ki67 index has been associated with poor prognosis and might play a relevant role in predicting benefit from adjuvant docetaxel, as observed in the article accompanying this editorial. Taxanes are one of the most active cytotoxic agents for breast cancer. However, the role of taxane-based chemotherapy as adjuvant treatment of early breast cancer remains controversial in some subsets of patients. For this reason, the Ki67 index might help to better define th... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5646910 Tue, 31 Jan 2012 05:00:00 +0100 5646910 http://www.medworm.com/index.php?rid=5646912&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR19 Conclusions: The GM over-predicts the risk of invasive breast cancer in an Asian developed-country setting as demonstrated in a large prospective trial, with the largest difference seen in older women aged between 60 and 64 years old. The reason for the discrepancy is likely to be multifactorial, including a true reduction of breast cancer, as well as lower mammographic screening prevalence locally. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5646912 Mon, 30 Jan 2012 05:00:00 +0100 5646912 http://www.medworm.com/index.php?rid=5637953&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F103 The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research, Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demonstrate that co-expression of CXCR7 and CXCR4 results in inhibition of CXCL12-mediated invasion, reduced intravasation of tumor cells into the vasculature, and fewer lung metastases compared with parental tumors. The results of this study suggest the combination of small molecule inhibitors of CXCR4 and CXCR7 could dramatically reduce invasion, intravasation, and metastasis and could be highly beneficial for the treatment of invasive breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5637953 Thu, 26 Jan 2012 05:00:00 +0100 5637953 http://www.medworm.com/index.php?rid=5637955&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR18 Conclusions: The tumorigenic and metastatic potential of a subpopulation of mammary epithelial/tumor cells in MMT mice is endowed relatively early in mammary neoplasms and suggests a potential role for cancer stem cell sub-populations in metastasis. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5637955 Wed, 25 Jan 2012 05:00:00 +0100 5637955 http://www.medworm.com/index.php?rid=5637954&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F102 Few studies have investigated the association of non-dense area or fatty breasts in conjunction with breast density and breast cancer risk. Two articles in a recent issue of Breast Cancer Research investigate the role of absolute non-dense breast area measured on mammograms and find conflicting results: one article finds that non-dense breast area has a modest positive association with breast cancer risk, whereas the other finds that non-dense breast area has a strong protective effect to reduce breast cancer risk. Understanding the interplay of body mass index, menopause status, and measurement of non-dense breast area would help to clarify the contribution of non-dense breast area to breast cancer risk. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5637954 Wed, 25 Jan 2012 05:00:00 +0100 5637954 http://www.medworm.com/index.php?rid=5637956&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR17 IntroductionRecently, several genome-wide association studies (GWAS) have identified novel single nucleotide polymorphisms (SNPs) associated with breast cancer risk. However, most of the studies were conducted among Caucasians and only one from Chinese. Methods: In the current study, we first tested whether 15 SNPs identified by previous GWAS were also breast cancer marker SNPs in this Chinese population. Then, we grouped the marker SNPs, and modeled them with clinical risk factors, to see the usage of these factors in breast cancer risk assessment. Two methods (risk factors counting and OR weighted risk scoring) were used to evaluate the cumulative effects of the 5 significant SNPs and two clinical risk factors (age at menarche and age at first live birth). Results: Five SNPs located at 2... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5637956 Mon, 23 Jan 2012 05:00:00 +0100 5637956 http://www.medworm.com/index.php?rid=5619613&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR16 Conclusions: Our findings demonstrate that STAT1 suppresses mammary tumor formation and its expression is frequently lost during breast cancer progression. Spontaneous mammary tumors that develop in STAT1-/- mice closely recapitulate the progression, ovarian hormone responsiveness, and molecular characteristics of human luminal breast cancer, the most common subtype of human breast neoplasms, and thus represent a valuable platform for testing novel treatments and detection modalities. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5619613 Fri, 20 Jan 2012 05:00:00 +0100 5619613 http://www.medworm.com/index.php?rid=5607956&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR15 Conclusion: Our data indicate that (1) a subset of primary breast cancer patients shows EMT and stem cell characteristics and (2) the currently used detection methods for CTC are not efficient to identify a subtype of CTC which underwent EMT. (3) The clinical relevance on prognosis and therapy response has to be further evaluated in a prospective trial. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5607956 Fri, 20 Jan 2012 05:00:00 +0100 5607956 http://www.medworm.com/index.php?rid=5607958&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F201 Aromatase inhibitors (AIs) have a central role in the treatment of breast cancer. However, resistance is a major obstacle to optimal management. Evidence from i) endocrine, molecular and pathological measurements in clinical material taken before and after therapy with AIs and ii) data from clinical trials in which AIs have been given as treatment either alone or in combination with other targeted agents suggest diverse causes for resistance. These include inherent tumour insensitivity to oestrogen, ineffective inhibition of aromatase, sources of oestrogenic hormones independent of aromatase, activation of signalling by non-endocrine pathways, enhanced cell survival and selection of hormone-insensitive cellular clones during treatment. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5607958 Thu, 19 Jan 2012 05:00:00 +0100 5607958 http://www.medworm.com/index.php?rid=5607957&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F202 Mortality from breast cancer has steadily been declining over the last decade, primarily due to earlier detection, adjuvant therapies and the advent of targeted therapies for ER positive and HER2 positive cancers [1, 2]. Despite these advances, a large number of patients relapse after an initial response to standard of care therapy. Novel therapies that prevent breast cancer relapse and metastasis are needed. An emerging hypothesis is that tumors contain a subpopulation of cells, called cancer stem cells (CSCs), which have the ability to self renew and regenerate the tumor. Increasingly, clinical evidence points to an intrinsic resistance to endocrine therapy and chemotherapy of this subpopulation of cancer stem cells [3]. The residual tumors after chemotherapy are enriched for CSCs and ha... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5607957 Thu, 19 Jan 2012 05:00:00 +0100 5607957 http://www.medworm.com/index.php?rid=5607959&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR14 MicroRNA let-7a binds directly to the 3'UTR of C-C chemokine receptor type 7 (CCR7), blocking its protein expression and suppressing migration and invasion of breast cancer cells. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5607959 Wed, 18 Jan 2012 05:00:00 +0100 5607959 http://www.medworm.com/index.php?rid=5607960&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR13 IntroductionLivial Intervention Following Breast Cancer; Efficacy, Recurrence and Tolerability Endpoints (LIBERATE - ClinicalTrials.gov number NCT00408863), a randomized, placebo controlled, double-blind trial which demonstrated that tibolone (Livial), a tissue selective hormone replacement therapy (HRT) increased breast cancer (BC) recurrence HR 1.40 (95% CI 1.14-1.70; p=0.001) entered a subgroup of women into a study of Bone Mineral Density (BMD). Methods: Women with surgically excised primary BC (T1-3, N0-2, M0) within the last 5 years complaining of vasomotor symptoms, were assigned to tibolone 2.5mg daily or placebo treatment for a maximum of 5 years. The BMD sub-study enrolled 763 patients utilizing dual-energy X-ray absorptiometry (DXA) scanning at baseline and at 2 years. Results: ... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5607960 Tue, 17 Jan 2012 05:00:00 +0100 5607960 http://www.medworm.com/index.php?rid=5596844&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR12 Conclusions: Our findings provide novel insights on the functional cross-talk between GPER and EGFR signaling. Furthermore, the exclusive antagonistic activity exerted by MIBE on ERalpha and GPER could represent an innovative pharmacological approach targeting breast carcinomas which express one or both receptors at the beginning and/or during tumor progression. Hence, the simultaneous inhibition of both ERalpha and GPER may guarantee major therapeutic benefits respect to the use of a selective estrogen receptor antagonist. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5596844 Tue, 17 Jan 2012 05:00:00 +0100 5596844 http://www.medworm.com/index.php?rid=5596845&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR11 Conclusions: This panel of human BC xenografts maintains the overall genomic and gene expression profile of the corresponding patient tumors and remains stable throughout sequential in vivo generations. The observed genomic profile and gene expression differences appear to be due to the loss of human stromal genes. These xenografts therefore represent a validated model for preclinical investigation of new therapeutic agents. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5596845 Mon, 16 Jan 2012 05:00:00 +0100 5596845 http://www.medworm.com/index.php?rid=5580851&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR9 Conclusions: Comparing the breast cancer mortality and breast cancer incidence between attenders and non-attenders, we have evaluated that the overall cost to save one life corresponds to no more than one overdiagnosed tumour (from 0.6 to 1 depending on the selection criteria of the cohort), even if a residual self-selection bias cannot be excluded. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5580851 Mon, 09 Jan 2012 05:00:00 +0100 5580851 http://www.medworm.com/index.php?rid=5580850&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR10 Conclusion: We observed no decline in the risk of advanced breast cancer during 12 years of biennial screening mammography. The majority of these cancers could not have been prevented through earlier detection at screening. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5580850 Mon, 09 Jan 2012 05:00:00 +0100 5580850 http://www.medworm.com/index.php?rid=5580849&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2F101 Septins comprise a conserved family of GTPase proteins. Of these, human SEPT9 has been widely implicated in cancers of epithelial origin, including breast cancer, as well as leukemia. In a previous issue of Breast Cancer Research, Connolly and colleagues present compelling data further supporting a role for SEPT9 isoforms in early breast cancer development as well as evidence suggesting that cellular localization patterns of SEPT9 isoforms may contribute to oncogenesis. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5580849 Mon, 09 Jan 2012 05:00:00 +0100 5580849 http://www.medworm.com/index.php?rid=5571845&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR6 Conclusion: These results demonstrate that HIF-1alpha plays a key role in promoting primary mammary tumor growth and metastasis, in part through regulation of TICs. HIF-1 regulates expression of several members of the Notch pathway, CD133 and markers of the basal lineage in mammary tumors. Our results suggest that CD133, which has not been profiled extensively in breast cancer, may be a useful marker of TICs in the PyMT model. These data reveal for the first time that HIF-1 directly regulates breast TIC activity in vivo. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571845 Sat, 07 Jan 2012 05:00:00 +0100 5571845 http://www.medworm.com/index.php?rid=5571844&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR7 We examined the association of inherited variation in genes from pathways that mediate cell division with percent mammographic density (PMD) adjusted for age, body mass index (BMI) and postmenopausal hormones, in two studies of healthy postmenopausal women. Methods: We investigated 2058 single nucleotide polymorphisms (SNPs) in 378 genes involved in regulation of mitosis for associations with adjusted PMD among 484 unaffected postmenopausal controls (without breast cancer) from the Mayo Clinic Breast Cancer Study (MCBCS) and replicated the findings in postmenopausal controls (n=726) from the Singapore and Sweden Breast Cancer Study (SASBAC) study. PMD was assessed in both studies by a computer-thresholding method (Cumulus) and linear regression approaches were used to assess the associatio... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571844 Sat, 07 Jan 2012 05:00:00 +0100 5571844 http://www.medworm.com/index.php?rid=5571843&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR8 Conclusions: Hyperinsulinemia in a mouse model promotes breast cancer metastasis to lung. Therapies to reduce insulin levels in hyperinsulinemic patients suffering from breast cancer could lessen the likelihood of metastatic progression. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571843 Sat, 07 Jan 2012 05:00:00 +0100 5571843 http://www.medworm.com/index.php?rid=5571850&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR1 Conclusions: Since an individual's dietary preferences can impact dietary adherence and weight loss success, the lack of evidence of a negative effect of dietary pattern on biomarkers associated with cardiovascular risk is an important consideration in the development of breast cancer practice guidelines for physicians who recommend that their patients lose weight. Whether dietary pattern affects biomarkers that predict long term survival is a primary question in this ongoing clinical trial. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571850 Fri, 06 Jan 2012 05:00:00 +0100 5571850 http://www.medworm.com/index.php?rid=5571849&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR2 Conclusions: We report for the first time that taxanes can promote dose-dependent sTNFalpha production in tumour cells at clinically relevant concentrations, which can contribute to their cytotoxicity. Defects in the TNF cytotoxicity pathway or activation of TNF-dependent NF-kappaB survival genes may, in contrast, contribute to taxane resistance in tumour cells. These findings may be of strong clinical significance. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571849 Fri, 06 Jan 2012 05:00:00 +0100 5571849 http://www.medworm.com/index.php?rid=5571848&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR3 Conclusions: Assessment of proliferation using Ki67LI and MS can distinguish subgroups of patients within luminal/hormone receptor positive breast cancer significantly different in clinical outcomes. Overall, both Ki67LI and mitotic count scores showed comparable results. The methodology described could provide a cost effective method for prognostic sub-classification of luminal/hormone receptor positive breast cancer in routine clinical practice. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571848 Fri, 06 Jan 2012 05:00:00 +0100 5571848 http://www.medworm.com/index.php?rid=5571847&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR4 Conclusions: Our results suggest that transamidation activity of TG2 is not essential for promoting its oncogenic functions and provide strong rationale for developing small molecule inhibitors to block GTP-binding pockets of TG2. Such inhibitors may have great potential for inhibiting the TG2-regulated pathways and for reversing drug resistance and inhibiting metastasis of cancer cells. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571847 Fri, 06 Jan 2012 05:00:00 +0100 5571847 http://www.medworm.com/index.php?rid=5571846&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F14%2F1%2FR5 Conclusions: Disparities found in case fatality among immigrants by age, duration of residence, age at immigration and country of birth emphasize the importance of targeting interventions on women that are not likely to attend screening or are not likely to adhere to the therapy suggested by physicians. The lower risk of breast cancer amongst immigrant women calls for more knowledge about how the lifestyle factors in these women differ from those with high risk, so that preventative measures may be implemented. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5571846 Fri, 06 Jan 2012 05:00:00 +0100 5571846 http://www.medworm.com/index.php?rid=5551876&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR134 Patients with breast cancer detected in mammography screening have a more favorable prognosis than those diagnosed outside a screening program and this should be taken into account in order to avoid over-treatment of screen-detected patients. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5551876 Wed, 28 Dec 2011 05:00:00 +0100 5551876 http://www.medworm.com/index.php?rid=5537373&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR133 Potential geographic and ethnic variations in the prevalence of EGFR mutations in triple negative breast cancer have implications for clinical trial design for anti-estrogen growth factor receptor (EGFR) therapies. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5537373 Thu, 22 Dec 2011 05:00:00 +0100 5537373 http://www.medworm.com/index.php?rid=5523979&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR132 Conclusions: The suggestive peaks and the larger linkage signal seen in the subset of pedigrees with younger participants highlight regions of interest for further study to identify genes that determine MD with the goal to understand mammographic density and its involvement in susceptibility to breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5523979 Wed, 21 Dec 2011 05:00:00 +0100 5523979 http://www.medworm.com/index.php?rid=5514964&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR131 Conclusions: G28UCM inhibits FASN activity and the growth of breast carcinoma xenografts in vivo, and is active in cells with acquired resistance to anti-HER2 drugs, which make it a candidate for further pre-clinical development. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5514964 Fri, 16 Dec 2011 05:00:00 +0100 5514964 http://www.medworm.com/index.php?rid=5504235&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR130 Conclusions: Inherited variation in the PTEN promoter region affects the tumor progression and gene expression profile in breast cancer. Further studies are warranted to establish PTEN promoter variants as clinical markers for prognosis in breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5504235 Thu, 15 Dec 2011 05:00:00 +0100 5504235 http://www.medworm.com/index.php?rid=5504236&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR129 IntroductionHER2-amplified breast cancer represents a clinically well-defined subgroup due to availability of targeted treatment. However, HER2-amplified tumors have been shown to be heterogeneous at the genomic level by genome-wide microarray analyses, pointing towards a need of further investigations for identification of recurrent copy number alterations and delineation of patterns of allelic imbalance. Methods: High-density whole genome array-based comparative genomic hybridisation (aCGH) and SNP array data from 260 HER2-amplified breast tumors or cell lines, and 346 HER2-negative breast cancers with molecular subtype information were assembled from different repositories. Copy number alteration (CNA), loss-of-heterozygosity (LOH), copy number neutral allelic imbalance (CNN-AI), subclo... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5504236 Wed, 14 Dec 2011 05:00:00 +0100 5504236 http://www.medworm.com/index.php?rid=5486272&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR127 Conclusions: E2 antagonizes Runx2-induced EMT and invasiveness of BCa cells, partly through attenuating expression of SNAI2, a Runx2 target required for mediating its pro-metastatic property. That ERalpha loss promotes non-osseous metastasis by unleashing Runx2/SNAI2 is supported by negative correlation observed in corresponding tumors. Unknown mechanisms in bone-seeking BCa allow high Runx2/SNAI2 expression despite high ERalpha levels. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5486272 Fri, 09 Dec 2011 05:00:00 +0100 5486272 http://www.medworm.com/index.php?rid=5486271&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR128 Conclusions: We find that CXCR4 and CXCR7 play different roles in metastasis, with CXCR4 mediating breast cancer invasion and CXCR7 impairing invasion but enhancing primary tumor growth through angiogenesis. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5486271 Fri, 09 Dec 2011 05:00:00 +0100 5486271 http://www.medworm.com/index.php?rid=5486275&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR126 IntroductionInfiltration of breast tumors by lymphocytes (TIL) has been linked to sensitivity to anthracycline-based chemotherapy. However, it is unclear if this is true within the estrogen receptor alpha negative (ER-) subset of breast tumors that manifest relatively high inherent TIL levels. Methods: The association of TIL with short-term and long-term clinical response to anthracycline-based therapy was assessed in two independent ER- breast cancer cohorts in which patients were categorized as TIL-high or TIL-low. We defined an 8-gene lymphocyte mRNA expression signature (including CD19, CD3D, CD48, GZMB, LCK, MS4A1, PRF1, and SELL) and used unsupervised hierarchical clustering to examine the association between TIL and short-term response to neoadjuvant chemotherapy in a previously pub... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5486275 Thu, 08 Dec 2011 05:00:00 +0100 5486275 http://www.medworm.com/index.php?rid=5486274&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F230 Early detection of metastasis prone breast cancers and characterization of residual metastatic cancers are important in efforts to improve management of breast cancer. Applications of genome scale molecular analysis technologies are making these complementary approaches possible by revealing molecular features uniquely associated with metastatic disease. Assays that reveal these molecular features will facilitate development of anatomic, histological and blood based strategies that may enable detection prior to metastatic spread. Knowledge of these features also will guide development of therapeutic strategies that can be applied when metastatic disease burden is low thereby increasing the probability of a curative response. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5486274 Thu, 08 Dec 2011 05:00:00 +0100 5486274 http://www.medworm.com/index.php?rid=5486273&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F318 Two recent studies on a rare androgen-dependent form of breast cancer have shed light on the biology of luminal tumours and reinforced the view that interfering with androgen signalling may have a place in the therapy of some forms of breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5486273 Thu, 08 Dec 2011 05:00:00 +0100 5486273 http://www.medworm.com/index.php?rid=5468331&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR124 Conclusion: These data demonstrate for the first time that EpCAM expression can influence the JNK/AP-1 signal transduction pathway, and suggest that modulation of AP-1 transcription factor activity contributes to EpCAM-dependent breast cancer invasion. These data have important implications for the design and application of molecular therapies targeting EpCAM. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468331 Thu, 01 Dec 2011 05:00:00 +0100 5468331 http://www.medworm.com/index.php?rid=5468330&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR125 Conclusions: The PI3K pathway is active in most BCBM regardless of subtype. Inhibition of this pathway represents a promising therapeutic strategy for patients with BCBM, a group of patients with poor prognosis and limited systemic therapeutic options. While expression of the PI3K pathway did not correlate with OS and survival following BCBM, PTEN- association with time to recurrence and OS (among patients with TNBC) is worthy of further study. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468330 Thu, 01 Dec 2011 05:00:00 +0100 5468330 http://www.medworm.com/index.php?rid=5468335&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR122 IntroductionTriple-negative breast cancer (TNBC), which is characterized by negativity for estrogen receptor, progesterone receptor, and HER2, is a high risk breast cancer that lacks specific targets for treatment selection. Chemotherapy is therefore the primary systemic modality used in the treatment of this disease, but reliable parameters to predict the chemosensitivity of TNBC have not been clinically available. Methods: A total of 190 TNBC patients who had undergone a curative resection of a primary breast cancer were enrolled. The adjuvant chemotherapy was performed for 138 (73%) of 190 TNBC cases; 60 cases had an anthracyclin-based regimen and 78 a 5-fluorouracil-based regimen. The prognostic value of E-cadherin, Ki67, and p53 expression in the outcome of TNBC patients with adjuvant... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468335 Wed, 30 Nov 2011 05:00:00 +0100 5468335 http://www.medworm.com/index.php?rid=5468334&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR123 Conclusions: The data support the clinical development of MGAH22, which may have utility in patients with low HER2 expressing tumors or carrying the CD16A low-binding allele. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468334 Wed, 30 Nov 2011 05:00:00 +0100 5468334 http://www.medworm.com/index.php?rid=5468333&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F221 Gene expression profiling has led to a new molecular classification of breast cancer characterized by four intrinsic subtypes: basal-like; erbB2/HER2-positive; luminal-A; and luminal-B. Despite expressing estrogen receptor, the luminal-B subtype confers increased risk of early relapse with endocrine therapy compared to luminal-A. Although luminal-B definitions vary, the hallmark appears to be increased expression of proliferation-related genes. Several biological pathways are identified as possible contributors to the poor outcomes and novel agents targeting these pathways are being developed with aims to improve survival. We review the definition of luminal-B breast cancer, its pathological and clinical features and potential targets for treatment. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468333 Wed, 30 Nov 2011 05:00:00 +0100 5468333 http://www.medworm.com/index.php?rid=5468332&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F229 Consistent with their essential role in cell adhesion to the extracellular matrix, integrins and their associated signaling pathways have been shown to be involved in cell proliferation, migration, invasion and survival, processes required in both tumorigenesis and metastasis. beta1 integrins represent the predominantly expressed integrins in mammary epithelial cells and have been proven to be crucial for mammary gland development and differentiation. Here we provide an overview of the studies that have used transgenic mouse models of mammary tumorigenesis to establish beta1 integrin as a critical mediator of breast cancer progression and thereby as a potential therapeutic target for the development of new anticancer strategies (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468332 Wed, 30 Nov 2011 05:00:00 +0100 5468332 http://www.medworm.com/index.php?rid=5468337&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR121 Combined lapatinib and trastuzumab therapy may improve outcomes in patients with human epidermal growth factor 2 (HER2)-positive breast cancer; adding estrogen receptor inhibition may be optimal in some patients. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468337 Mon, 28 Nov 2011 05:00:00 +0100 5468337 http://www.medworm.com/index.php?rid=5468336&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F317 Exemplified by the cancer cell's preference for glycolysis (the Warburg effect), altered metabolism has taken center stage as an emerging hallmark of cancer. Charting the landscape of cancer metabolic addictions should reveal new avenues for therapeutic attack. Two recent studies found subsets of human melanoma and breast cancers to have high levels of phopsoglycerate dehydrogenase (PHGDH), a key enzyme for serine biosynthesis, and these cancer cells are dependent on PHGDH for their growth and survival. Thus tumors may harbor distinct metabolic alterations to support their malignancy and targeting enzymes such as PHGDH might prove a viable therapeutic strategy in this scenario. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5468336 Mon, 28 Nov 2011 05:00:00 +0100 5468336 http://www.medworm.com/index.php?rid=5440242&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR119 Conclusion: Our work indicates that a variety of deleterious CHEK2 alleles make an appreciable contribution to breast cancer susceptibility, and their identification could help the clinical management of patients carrying a CHEK2 mutation. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5440242 Thu, 24 Nov 2011 05:00:00 +0100 5440242 http://www.medworm.com/index.php?rid=5440241&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR120 Conclusions: Data for the first time document that targeting cholesterol rich lipid microdomains is a potential strategy to circumvent TAMR and combination of alpha-TEA + TAM can circumvent TAMR by suppression of pro-survival signaling via disruption of cholesterol rich lipid microdomains and activation of apoptotic pathways via induction of endoplasmic reticulum stress. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5440241 Thu, 24 Nov 2011 05:00:00 +0100 5440241 http://www.medworm.com/index.php?rid=5440245&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR116 Conclusions: These findings reveal miR-34b as an onco-suppressor microRNA requiring both ER-positive and wild-type p53 phenotypes in breast cancer cells. These results improve our knowledge for developing new therapeutic strategies to target the complex estrogenic pathway in human breast cancer progression through microRNA regulation. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5440245 Wed, 23 Nov 2011 05:00:00 +0100 5440245 http://www.medworm.com/index.php?rid=5440244&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR117 Conclusions: Compared to HER2- cases, patients with HER2-overexpressing locally advanced breast cancer show a more limited tumor-related immune suppression. This may account for the clinical benefit achieved in this subset of patients with the use of drugs acting through, but also promoting, immune-mediated effects. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5440244 Wed, 23 Nov 2011 05:00:00 +0100 5440244 http://www.medworm.com/index.php?rid=5440243&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR118 Conclusion: Breast CSC markers do not identify identical subpopulations in primary tumours. Both ITGA6 and a composite Total CSC score show independent prognostic significance in ER- disease. The use of multiple markers to identify tumours enriched for CSCs has greatest prognostic value. In the absence of more specific markers, we propose that the effective translation of the CSC hypothesis into patient benefit will necessitate the use of a panel of markers to robustly identify tumours enriched for CSCs. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5440243 Wed, 23 Nov 2011 05:00:00 +0100 5440243 http://www.medworm.com/index.php?rid=5421454&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR114 Conclusion: Our results indicate that some common risk variants associated with primary breast cancer also increase risk for contralateral breast cancer, and that these risks vary with the ER status of the first tumor. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5421454 Thu, 17 Nov 2011 05:00:00 +0100 5421454 http://www.medworm.com/index.php?rid=5421453&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR115 Conclusion: Our study is the first to show that the proteolytic activity of cathepsin B and its co-expression with caveolin-1 contributes to the aggressiveness of IBC. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5421453 Thu, 17 Nov 2011 05:00:00 +0100 5421453 http://www.medworm.com/index.php?rid=5406996&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR113 Conclusion: Our study reveals the existence of a potential, regulatory network governed by the interaction of nicotine and nAChR that integrates the conventional, mitogenic Src and EGFR signals for breast cancer development. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5406996 Tue, 15 Nov 2011 05:00:00 +0100 5406996 http://www.medworm.com/index.php?rid=5384308&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR112 Conclusions: ARTN and TWIST1 synergize to produce a worse outcome in ER-MC and combined inhibition of ARTN and Phosphatidylinositol 3-kinase/ protein kinase B (PI3K/AKT) may therefore provide a novel therapeutic strategy in this subtype of mammary carcinoma. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384308 Mon, 07 Nov 2011 05:00:00 +0100 5384308 http://www.medworm.com/index.php?rid=5384309&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR111 Conclusions: IRF5 is an important tumor suppressor that regulates multiple cellular processes (i.e. growth, response to DNA damage, and invasion/metastasis) involved in the conversion of normal mammary epithelial cells to tumor epithelial cells with metastatic potential. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384309 Fri, 04 Nov 2011 04:00:00 +0100 5384309 http://www.medworm.com/index.php?rid=5384310&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2FR110 Conclusions: The associations of the twelve SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumor subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384310 Wed, 02 Nov 2011 04:00:00 +0100 5384310 http://www.medworm.com/index.php?rid=5399994&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F227 Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized as a critical participant in tumor progression and therapeutic responses. Recent data demonstrate significant gene expression and epigenetic alterations in cells composing the microenvironment during disease progression, which can be explored as biomarkers and targets for therapy. Indeed, gene expression signatures derived from tumor stroma have been linked to clinical outcomes. There is increasing interest in translating our current understanding of the tumor microenvironment to the development of novel therapies. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5399994 Tue, 01 Nov 2011 04:00:00 +0100 5399994 http://www.medworm.com/index.php?rid=5384315&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F113 Over the past 50 years, deaths from cardiovascular disease, stroke and pneumonia have plummeted as a result of new therapies and preventive strategies based upon a detailed understanding of the causes and pathogenesis of these diseases. Over this same period, deaths from cancer have changed relatively little. Consequently, we have now reached a tipping point in history at which deaths from cancer will soon surpass those from cardiovascular disease. In this regard, breast cancer holds the dubious honor of having become the leading cause of cancer mortality among women worldwide. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384315 Tue, 01 Nov 2011 04:00:00 +0100 5384315 http://www.medworm.com/index.php?rid=5384314&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F223 Variations in percent mammographic density (PMD) reflect variations in the amounts of collagen and number of epithelial and non-epithelial cells in the breast. Extensive PMD is associated with a marked increased risk of invasive breast cancer. The PMD phenotype is important in the context of breast cancer prevention because extensive PMD is common in the population, is strongly associated with risk of the disease, and unlike most breast cancer risk factors, can be changed.Work now in progress makes it likely that measurement of PMD will be improved in the near future, and that understanding of the genetics and biological basis of the association of PMD with breast cancer risk will also improve. Future prospects for the application of PMD include mammographic screening, risk prediction in i... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384314 Tue, 01 Nov 2011 04:00:00 +0100 5384314 http://www.medworm.com/index.php?rid=5384313&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F224 Mutations in genes that constitute the phosphatidylinositol 3-kinase (PI3K) pathway occur in >70% of breast cancers. Clinical and experimental evidence suggest that PI3K pathway activation promotes resistance to some of the current breast cancer therapies. PI3K is a major signaling hub downstream of HER2 and other receptor tyrosine kinases. PI3K activates AKT, SGK, PDK1, mTOR, and several other molecules involved in cell cycle progression and survival. In ER+ breast cancer cells, PI3K activation promotes estrogen-dependent and -independent ER transcriptional activity which, in turn, may contribute to antiestrogen resistance. Activation of this pathway also confers resistance to HER2-targeted therapies. In experimental models of resistance to antiestrogens and HER2 inhibitors, pharmacologic... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384313 Tue, 01 Nov 2011 04:00:00 +0100 5384313 http://www.medworm.com/index.php?rid=5384312&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F225 Epigenetic changes are critical for development and progression of cancers, including breast cancer. Significant progress has been made in the basic understanding of how various epigenetic changes such as DNA methylation, histone modification, miRNA expression, and higher order chromatin structure affect gene expression. In this review we will focus on methylation and demethylation of histones. While the acetylation of histones has been at the forefront of well-characterized posttranslational modifications of histones, including the development of inhibitors targeting de-acetylating enzymes, the last few years have witnessed a dramatic increase in knowledge of the role of histone methylation/demethylation. This is an exciting and rapidly evolving area of research, with much promise for pot... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384312 Tue, 01 Nov 2011 04:00:00 +0100 5384312 http://www.medworm.com/index.php?rid=5384311&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F6%2F226 The epithelial-to-mesenchymal transition (EMT) is a critical developmental process that has recently come to the forefront of cancer biology. In breast carcinomas, acquisition of a mesenchymal-like phenotype that is reminiscent of an EMT, termed oncogenic EMT, is associated with pro-metastatic properties including increased motility, invasion, anoikis resistance, immunosuppression and cancer stem cell characteristics. This oncogenic EMT is a consequence of cellular plasticity, which allows for interconversion between epithelial and mesenchymal-like states, and is thought to enable tumor cells not only to escape from the primary tumor, but also to colonize a secondary site. Indeed, the plasticity of cancer cells may explain the range of pro-metastatic traits conferred by oncogenic EMT, such... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5384311 Tue, 01 Nov 2011 04:00:00 +0100 5384311 http://www.medworm.com/index.php?rid=5359765&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR108 Antibody-conjugated magnetic nanoparticles and superconducting quantum interference device sensors may provide a useful, viable and highly-sensitive alternative to mammographic screening in breast tumor cell detection. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5359765 Fri, 28 Oct 2011 04:00:00 +0100 5359765 http://www.medworm.com/index.php?rid=5359768&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR105 Conclusions: These results indicate that within the inflammatory bone microenvironment MMP-13 production was up-regulated in breast tumor cells leading to increased pre-osteoclast differentiation and their subsequent activation. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5359768 Thu, 27 Oct 2011 04:00:00 +0100 5359768 http://www.medworm.com/index.php?rid=5359767&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR106 Conclusion: This study demonstrates that Runx2 and CBFbeta are required for the expression of genes that mediate the ability of metastatic breast cancer cells to directly modulate both osteoclast and osteoblast function. We also show that Runx2-dependent inhibition of osteoblast differentiation by breast cancer cells is mediated through the Wnt antagonist, sclerostin. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5359767 Thu, 27 Oct 2011 04:00:00 +0100 5359767 http://www.medworm.com/index.php?rid=5359766&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR107 Conclusions: Since the MLPA assay can identify BRCA1-deficient breast cancer patients, this method could be applied both for clinical genetic testing and as a predictor of treatment benefit. BRCA1-like tumors are highly sensitive to chemotherapy with DNA damaging agents, and most likely to poly ADP ribose polymerase (PARP)-inhibitors. The MLPA assay is rapid and robust, can easily be multiplexed, and works well with DNA derived from paraffin-embedded tissues. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5359766 Thu, 27 Oct 2011 04:00:00 +0100 5359766 http://www.medworm.com/index.php?rid=5359770&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR103 When studying the relationship between breast dense area and breast cancer risk, adjustments for non-dense tissue may give more valid results than adjustment for BMI. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5359770 Wed, 26 Oct 2011 04:00:00 +0100 5359770 http://www.medworm.com/index.php?rid=5359769&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR104 Conclusions: Our results demonstrate a possible role for N-cad in the formation of fibrosis and cysts in the mammary gland. Moreover, we show that these lesions precede the development of malignant tumors. Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5359769 Wed, 26 Oct 2011 04:00:00 +0100 5359769 http://www.medworm.com/index.php?rid=5346776&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2F216 Recent efforts to understand breast cancer biology involve three interrelated themes that are founded on a combination of clinical and experimental observations. The central concept is "gene addiction." The clinical dilemma is the "escape" from gene addiction which is mediated, in part, by phenotypic plasticity as exemplified by epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET). Finally, cancer stem cells (CSC) are now recognized as the basis for minimal residual disease and malignant progression over time. These themes cooperate in breast cancer, as induction of EMT enhances CSC self-renewal, and expression of CSC and EMT markers facilitates tumor cell resistance. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5346776 Tue, 25 Oct 2011 04:00:00 +0100 5346776 http://www.medworm.com/index.php?rid=5346775&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F%2F Tumor cell dissemination in bone marrow or other organs is thought to represent an important step in the metastatic process. The detection of bone marrow disseminated tumor cells is associated with worse outcome in early breast cancer. Moreover, the detection of peripheral blood circulating tumor cells is an adverse prognostic factor in metastatic breast cancer and emerging data suggest that this is also true for early disease. Beyond enumeration, the characterization of these cells has the potential to improve risk assessment, treatment selection/monitoring, the development of novel therapeutic agents and advance our understanding of the biology of metastasis. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5346775 Tue, 25 Oct 2011 04:00:00 +0100 5346775 http://www.medworm.com/index.php?rid=5346778&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR101 Conclusions: Our data suggest that Hsp27 regulates EMT process and NF-kappa B activity to contribute the maintenance of BCSCs. Targeting Hsp27 may be considered as a novel strategy in breast cancer therapy. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5346778 Mon, 24 Oct 2011 04:00:00 +0100 5346778 http://www.medworm.com/index.php?rid=5346777&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR102 Pleurocidin-family cationic antimicrobial peptides are cytotoxic for multiple breast cancer cell lines and prevent growth of tumour xenografts, suggesting the possible use of NRC-03 and NRC-07 as novel anticancer agents. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5346777 Mon, 24 Oct 2011 04:00:00 +0100 5346777 http://www.medworm.com/index.php?rid=5334964&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR99 The presence of several sex and growth hormones at high levels increases breast cancer risk particularly for ER+ disease, and this observation should be considered when improving existing risk prediction models. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5334964 Fri, 21 Oct 2011 04:00:00 +0100 5334964 http://www.medworm.com/index.php?rid=5334963&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR100 Higher absolute non-dense area on a mammogram is associated with a decreased risk of breast cancer, suggesting adipose breast tissue may have a protective role against breast carcinogenesis. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5334963 Fri, 21 Oct 2011 04:00:00 +0100 5334963 http://www.medworm.com/index.php?rid=5313787&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR98 Breast Cancer Index is a significant predictor of distant recurrence and breast-cancer specific mortality; Adjuvant! Online was significantly associated with risk of recurrence; and both are significantly predictive of outcome. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5313787 Fri, 14 Oct 2011 04:00:00 +0100 5313787 http://www.medworm.com/index.php?rid=5313786&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2F316 The meeting of the European Network for Breast Development and Cancer (ENBDC) on "Methods in Mammary Gland Development and Cancer" has become an annual international rendezvous for scientists with interests in the normal and neoplastic breast. The third meeting in this series, held in April-May 2011 in Weggis, Switzerland, focussed on functional screens and sequencing, hormones, lineage tracing, tumor-stroma interactions and the expansion of human breast tumours as xenografts. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5313786 Fri, 14 Oct 2011 04:00:00 +0100 5313786 http://www.medworm.com/index.php?rid=5313788&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2F315 P53 mutations occur in 15-20% of all breast cancers, and with higher frequency in estrogen-receptor negative and high-grade tumors. Certainp53 mutations contribute to malignant transformation not only through loss of wild-type p53 but also through a gain of function of specific p53 mutations. How these hotspot mutations turn p53 from a tumor suppressor into an oncogene had until now remained incompletely understood. In an elegant paper published in the July 12 issue of Cancer Cell, Girardini and colleagues show how Pin1-mediated prolyl isomerization, a regulatory mechanism intended by evolutionto support p53's function as a guardian of the genome, can go haywire and accelerate malignant transformation when p53 carries a dominant-negative mutation. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5313788 Thu, 13 Oct 2011 04:00:00 +0100 5313788 http://www.medworm.com/index.php?rid=5303996&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2F112 Advances in genotyping technology have provided us with a large number of genetic loci associated with cancer susceptibility, however our ability to understand the functional effects of the genetic variants of these loci remains limited. In this issue, Smits and colleagues demonstrate the use of congenic rat strains to discover that the Mcs5a breast cancer susceptibility locus is most likely acting through the immune system, via novel transcriptional regulatory mechanisms. This challenges our conventional thinking of cancer susceptibility and gene regulation pathways, and illustrates the potential for rodent models to help us functionally characterize polymorphisms of cancer associated loci. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5303996 Wed, 12 Oct 2011 00:19:17 +0100 5303996 http://www.medworm.com/index.php?rid=5303995&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2F220 STAT5 consists of two proteins STAT5a/b. In normal mammary gland development STAT5 expression and activity are regulated by a prolactin signalling node including JAK2/Elf5 and EGF signalling networks with contributions from growth hormone, estrogen, progesterone and glucocorticoid signalling pathways. In mammary cancer c-Src and erythropoietin signalling can be added. STAT5 activation levels are impacted by AKT, Caveolin, PIKE-A, Pak1, c-Myb, Stap2, Brk, beta-integrin, Dystroglycan, other STATs and STAT pathway molecules JAK1, Shp-2, and SOCs. TGF-beta can down-regulate prolactin and PTPN9 can down-regulate EGF mediated STAT5 activation. IGF signalling, AKT, RANKL, Cyclin D1, BCL6, HSP90A and HOXA1 lie downstream of STAT5. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5303995 Wed, 12 Oct 2011 00:19:17 +0100 5303995 http://www.medworm.com/index.php?rid=5296498&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR97 IntroductionCurrent prognostic gene expression profiles for breast cancer mainly reflect proliferation status and are most useful in ER-positive cancers. Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease. Methods: We assembled Affymetrix gene expression data for 579 TNBC and performed unsupervised analysis to define metagenes that distinguish molecular subsets within TNBC. We used n=394 cases for discovery and n=185 cases for validation. Sixteen metagenes emerged that identified basal-like, apocrine and claudin-low molecular subtypes, or reflected various non-neoplastic cell populations including immune cells, blood, adipocytes, stroma, angiogenesis and inflammation within the cancer... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5296498 Thu, 06 Oct 2011 04:00:00 +0100 5296498 http://www.medworm.com/index.php?rid=5285052&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR96 Conclusions: We provide evidences that TG2 is an important link in IL-6-mediated tumor aggressiveness, and that TG2 could be an important mediator of distant metastasis, both in a xenograft animal model and in patients with advanced breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5285052 Mon, 03 Oct 2011 04:00:00 +0100 5285052 http://www.medworm.com/index.php?rid=5273091&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR95 Conclusions: The results presented here demonstrate divergent paths of tumor evolution in BRCA2 carriers and that deletion of the wild-type BRCA2 allele together with co-occurring changes at 6q, 11q, and 17q, are important events in progression towards advanced disease. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5273091 Thu, 29 Sep 2011 04:00:00 +0100 5273091 http://www.medworm.com/index.php?rid=5260024&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR94 Conclusions: Transduction of OCT4 in normal breast preparations lead to the generation of cell lines possessing tumor initiating and colonization capabilities. These cells developed high-grade, poorly differentiated breast carcinomas in nude mice. Genome-wide analysis of OTBCs outlined an embryonic TF circuitry that could be operative in TICs, resulting in up-regulation of oncogenes and loss of tumor suppressive functions. These OTBCs represent a patient-specific model system for the discovery of novel oncogenic targets in claudin-low tumors. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5260024 Tue, 27 Sep 2011 04:00:00 +0100 5260024 http://www.medworm.com/index.php?rid=5250131&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR92 Conclusions: CMTC correlates well with current clinical classification of BCs and has the potential to be easily integrated into routine clinical practice readily. Using FNABs, CMTC can be determined at the time of diagnostic needle biopsies for tumors of all sizes. Using the public databases as the validation cohort in our analyses, CMTC appeared to be able to provide treatment guidance more accurately, could be available in preoperative settings and applicable to all BC types independent of size, receptor and nodal status. The unique oncogenic signaling pathway pattern of each CMTC group may provide guidance to new treatment strategies. Further validation of CMTC will required prospective randomized controlled trials. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5250131 Thu, 22 Sep 2011 04:00:00 +0100 5250131 http://www.medworm.com/index.php?rid=5236665&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR90 Conclusions: We have shown that copy number aberrations of certain genomic regions are associated with CHEK2 mutation 1100delC. On these regions we have identified potential drivers of CHEK2 1100delC associated tumorigenesis, whose role in cancer progression is worth investigating. Furthermore, poorer survival related to the CHEK2 1100delC gene expression signature highlights pathways that are likely to have a role in the development of metastatic disease in carriers of CHEK2 1100delC mutation. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5236665 Tue, 20 Sep 2011 04:00:00 +0100 5236665 http://www.medworm.com/index.php?rid=5236664&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR91 Conclusions: We provide compelling evidence that the functional interactions between fractalkine produced by both the endothelial and stromal cells of bone marrow and the CX3CR1 receptor on breast cancer cells are determinant in the arrest and initial lodging needed for skeletal dissemination. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5236664 Tue, 20 Sep 2011 04:00:00 +0100 5236664 http://www.medworm.com/index.php?rid=5224572&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR89 Conclusions: These studies illustrate that forced expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation. Brk expression in human breast tumors may contribute to progression by inducing p38-driven pro-survival signaling pathways. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5224572 Sat, 17 Sep 2011 04:00:00 +0100 5224572 http://www.medworm.com/index.php?rid=5224573&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR88 Conclusions: We describe an apoptotic mechanism that selectively and repeatedly removes bCSC activity from breast cancer cell lines and suggest that a combined TRAIL/FLIPi therapy could prevent metastatic disease progression in a broad range of breast cancer subtypes. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5224573 Wed, 14 Sep 2011 04:00:00 +0100 5224573 http://www.medworm.com/index.php?rid=5224575&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR86 Conclusions: Elevated serum U6 levels in breast cancer patients irrespective of disease activity at the time of serum collection suggest a new paradigm in cancer; persistent systemic changes during cancer progression, which result in elevated activity of RNAP-III and/or the stability/release pathways of U6 in non-cancer tissues. Additionally, these results highlight the need for developing standards for normalization between samples in microRNA-related studies for healthy versus cancer and for inter-laboratory reproducibility. Our studies rule out the utility of miR-16, U6 and 5S RNAs for this purpose. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5224575 Tue, 13 Sep 2011 04:00:00 +0100 5224575 http://www.medworm.com/index.php?rid=5224574&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR87 Conclusions: Breast tumor biological subtypes have a tendency to give rise to first distant metastases at certain body sites. Several primary tumor proteins were associated with homing of breast cancer cells. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5224574 Tue, 13 Sep 2011 04:00:00 +0100 5224574 http://www.medworm.com/index.php?rid=5207727&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2F314 The hereditary breast and ovarian cancer predisposition genes, BRCA1 and BRCA2 account for the lion's share of heritable breast cancer risk in the human population. Loss of function of either gene results in defective homologous recombination (HR) and triggers genomic instability, accelerating breast tumorigenesis. A long-standing hypothesis proposes that BRCA1 and BRCA2 mediate HR following attempted replication across damaged DNA, ensuring error-free processing of the stalled replication fork. A recent paper describes a new replication fork protective function of BRCA2, which appears to collaborate with its HR function to suppress genomic instability. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5207727 Wed, 07 Sep 2011 04:00:00 +0100 5207727 http://www.medworm.com/index.php?rid=5183160&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F5%2FR85 Conclusions: Quantitative measurement of MAP-tau expression has prognostic value in both cohorts, with high expression associated with longer TTP and OS. Differences by treatment arm or response rate in low versus high MAP-tau groups were not observed indicating that MAP-tau is not associated with response to taxanes and is not a useful predictive marker for taxane-based chemotherapy. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5183160 Thu, 01 Sep 2011 23:00:00 +0100 5183160 http://www.medworm.com/index.php?rid=5183162&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR83 Conclusions: Our results have identified a brief, defined window in which activation of NF-kappaB has significant anti-metastatic effects and inhibition of NF-kappaB results in a worse outcome. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5183162 Tue, 30 Aug 2011 23:00:00 +0100 5183162 http://www.medworm.com/index.php?rid=5183161&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR84 Conclusions: Our data suggest that HER2 activity, which is suppressed in resistance involving L but not T alone, dictates whether beta1 mediates an alternative pathway driving resistance. Our findings justify clinical studies investigating the inhibition of beta1 or its downstream signaling moieties as strategies to overcome acquired L and LT resistance. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5183161 Tue, 30 Aug 2011 23:00:00 +0100 5183161 http://www.medworm.com/index.php?rid=5160833&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR82 Conclusions: TRIB3 is independently associated with poor prognosis of breast cancer patients, possibly through its association with tumor cell hypoxia. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5160833 Tue, 23 Aug 2011 23:00:00 +0100 5160833 http://www.medworm.com/index.php?rid=5143003&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F111 Metastatic process is multistep coordinated event with an high degree of efficiency. A specific sub-populations of cancer stem cells with tumor-initiating and migratory capacity can selectively migrate towards sites that are able to promote survival, and/or proliferation of metastatic tumor cells through a microenvironment modification. Cross-talking between bone microenvironment and cancers cells can facilitate bone tropism of cancers cells.Understanding deeply this complexity represent a major challenge in anti-cancer research and a mandatory step towards the development of new drugs potentially able not only to reduce the consequences of bone lesions but also to target metastatic process in visceral sites. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5143003 Mon, 15 Aug 2011 23:00:00 +0100 5143003 http://www.medworm.com/index.php?rid=5143002&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F217 Preclinical investigations and selected clinical observational studies support an association between higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk. However, the recently updated report from the Institute of Medicine concluded that, for cancer and vitamin D, the evidence was "inconsistent and insufficient to inform nutritional requirements". Against this background, reports examining vitamin D intake, 25-hydroxyvitamin D levels and breast cancer incidence and outcome were reviewed. Current evidence supports pursuit of several research questions but not routine 25-hydroxyvitamin D monitoring and vitamin D supplementation to reduce breast cancer incidence or improve breast cancer outcome. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5143002 Mon, 15 Aug 2011 23:00:00 +0100 5143002 http://www.medworm.com/index.php?rid=5143001&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F218 Inhibitors of poly(ADP-ribose) polymerase mediated DNA repair have shown promise in early clinical studies in the treatment of specific subgroups of breast cancer. Notably, phase II trials indicate that olaparib, an oral PARP inhibitor, has activity as a single agent in BRCA-related tumours, and that a combination of iniparib, an intravenous PARP inhibitor, and chemotherapy offers a survival advantage, compared with chemotherapy alone, in triple-negative breast cancer. Phase III data on the latter indication are expected in 2011. Intriguingly, iniparib does not increase toxicity when used as a chemo-potentiating agent, suggesting that it differs in its mechanism of action from other agents in this class. Overall PARP inhibitors represent a potentially important new class of anti-cancer age... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5143001 Mon, 15 Aug 2011 23:00:00 +0100 5143001 http://www.medworm.com/index.php?rid=5143000&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F313 Epithelial to mesenchymal transition (EMT) is an essential process in embryonic development and is aberrantly induced in many disease settings. Work carried out by Chonghui Cheng's lab addressed the involvement of alternative RNA splicing in EMT and its link to tumour progression. They describe a switch in CD44 expression from variant isoform(s) to the standard isoform and showed, for the first time, that this is required for normal epithelial cells to undergo EMT. In addition, they link expression of the CD44 standard isoform to activation of the PI3K/Akt pathway and apoptosis resistance in a mouse model of recurrent disease and with high grade human breast cancer samples. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5143000 Mon, 15 Aug 2011 23:00:00 +0100 5143000 http://www.medworm.com/index.php?rid=5142999&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F312 Despite the undoubted success of adjuvant endocrine therapies that target the estrogen receptor pathway, not all women with estrogen receptor-positive breast cancer respond to these therapies, and many who initially respond will subsequently relapse. Deregulation of various aspects of estrogen receptor signaling has been highlighted as a mechanism of resistance and as a basis for alternative therapeutic approaches. However, a recent publication refocuses attention on the estrogen receptor itself by showing that the ubiquitin-binding CUE domain-containing protein 2 is a regulator of estrogen receptor protein degradation and a marker of endocrine resistance in breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5142999 Mon, 15 Aug 2011 23:00:00 +0100 5142999 http://www.medworm.com/index.php?rid=5131613&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR81 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5131613 Mon, 15 Aug 2011 23:00:00 +0100 5131613 http://www.medworm.com/index.php?rid=5119588&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR77 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5119588 Wed, 10 Aug 2011 23:00:00 +0100 5119588 http://www.medworm.com/index.php?rid=5119587&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR78 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5119587 Wed, 10 Aug 2011 23:00:00 +0100 5119587 http://www.medworm.com/index.php?rid=5119586&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR79 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5119586 Wed, 10 Aug 2011 23:00:00 +0100 5119586 http://www.medworm.com/index.php?rid=5119585&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR80 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5119585 Wed, 10 Aug 2011 23:00:00 +0100 5119585 http://www.medworm.com/index.php?rid=5096419&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR75 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5096419 Wed, 03 Aug 2011 23:00:00 +0100 5096419 http://www.medworm.com/index.php?rid=5069946&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR74 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5069946 Mon, 25 Jul 2011 23:00:00 +0100 5069946 http://www.medworm.com/index.php?rid=5063224&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F214 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5063224 Mon, 25 Jul 2011 23:00:00 +0100 5063224 http://www.medworm.com/index.php?rid=5063225&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR73 ${item.shortDescription} (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5063225 Sun, 24 Jul 2011 23:00:00 +0100 5063225 http://www.medworm.com/index.php?rid=5037897&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR72 Conclusions: The influence of rs2981578 genotypes on FGFR2 mRNA expression levels is cell type-dependent. Expression differences correlated well with signaling levels of the FGFR2 pathway. Our results suggest that the increased breast cancer risk associated with SNP rs2981578 is due to increased FGFR2 signaling activity in stromal fibroblasts, possibly also involving paracrine FGF10 signaling. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5037897 Sun, 17 Jul 2011 23:00:00 +0100 5037897 http://www.medworm.com/index.php?rid=5019927&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F406 Blank (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5019927 Mon, 11 Jul 2011 23:00:00 +0100 5019927 http://www.medworm.com/index.php?rid=5019928&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2FR71 IntroductionCirculating tumor cells (CTCs) reflect aggressive tumor behavior by hematogenous tumor cell dissemination. The tissue inhibitor of metalloproteinase 1 (TIMP-1) plays a role in tissue invasion and is also involved in angiogenesis, abrogation of apoptosis and in chemoresistance. Carbonic anhydrase IX (CAIX) is a metalloenzyme involved in cell adhesion, growth and survival of tumor cells. The aim of the study was to investigate whether serum concentrations of TIMP-1 and CAIX are associated with the detection of CTC in metastatic breast cancer. Methods: Blood was obtained in a prospective multicenter setting from 253 patients with metastatic breast cancer at the time of disease progression. Serum TIMP-1 and CAIX were determined using commercial ELISA-kits (Oncogene Science). CTC we... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5019928 Sun, 10 Jul 2011 23:00:00 +0100 5019928 http://www.medworm.com/index.php?rid=5009388&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F4%2F213 Cancer cells show a broad spectrum of bioenergetic states, with some cells using aerobic glycolysis, while others relying on oxidative phosphorylation as their main source of energy. In addition, there is mounting evidence that metabolic coupling occurs in aggressive tumors, between epithelial cancer cells and the stromal compartment, and between well-oxygenated and hypoxic compartments. We recently showed that oxidative stress in the tumor stroma, due to aerobic glycolysis and mitochondrial dysfunction, is important for cancer cell mutagenesis and tumor progression. More specifically, increased autophagy/mitophagy in the tumor stroma and conversely decreased autophagy in the epithelial compartment, drives a form of parasitic epithelial-stromal metabolic coupling. These findings also expla... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=5009388 Thu, 07 Jul 2011 23:00:00 +0100 5009388 http://www.medworm.com/index.php?rid=4985403&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F405 Upon publication of our article [1], we noticed that the wrong figure had been uploaded for figure 6a. The figure as it should appear can be found overleaf. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4985403 Wed, 29 Jun 2011 23:00:00 +0100 4985403 http://www.medworm.com/index.php?rid=4977224&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR70 Conclusions: This study reveals that 14-3-3zeta is a key predictive marker for risk of failure on endocrine therapy and serves a pivotal role impacting growth factor signaling, and promoting cell survival and resistance to endocrine therapies. Targeting 14-3-3zeta and its coregulated proteins, such as FOXM1, should prove valuable in restoring endocrine sensitivity and reducing risk of breast cancer recurrence. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4977224 Tue, 28 Jun 2011 23:00:00 +0100 4977224 http://www.medworm.com/index.php?rid=4969766&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F212 Breast cancer comprises a collection of diseases with distinctive clinical, histopathological and molecular levels features. Importantly, tumours with similar histological features may display disparate clinical behaviours. Gene expression profiling using microarray technologies has improved our understanding of breast cancer biology, and has led to the development of a breast cancer molecular taxonomy and of multigene signatures to predict outcome and response to systemic therapies. The use of these prognostic and predictive signatures in routine clinical decision-making remains controversial. Here, we review the clinical relevance of microarray-based profiling of breast cancer and discuss its impact on patient management. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4969766 Sun, 26 Jun 2011 23:00:00 +0100 4969766 http://www.medworm.com/index.php?rid=4969765&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR69 Blank (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4969765 Sun, 26 Jun 2011 23:00:00 +0100 4969765 http://www.medworm.com/index.php?rid=4969764&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR70 Upon publication of our article [1], we noticed that the wrong figure had been uploaded for figure 6a. The figure as it should appear can be found overleaf. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4969764 Sun, 26 Jun 2011 23:00:00 +0100 4969764 http://www.medworm.com/index.php?rid=4969767&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR68 Conclusions: Molecular subtype is a strong independent prognostic factor in breast cancer patients younger than 40 years of age. These data support the use of established prognostic factors as a diagnostic tool to assess disease outcome and to plan systemic treatment strategies in young breast cancer patients. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4969767 Thu, 23 Jun 2011 23:00:00 +0100 4969767 http://www.medworm.com/index.php?rid=4969768&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR67 IntroductionCirculating tumor cells (CTCs) represent an independent predictor of outcome in patients with metastatic breast cancer (MBC). We assessed the prognostic impact of CTCs according to different first-line systemic treatments, and explored their potential predictive value in MBC patients. Methods: We retrospectively evaluated 235 newly diagnosed MBC patients, treated at the University of Texas MD Anderson Cancer Center. All patients had a baseline CTC assessment performed with CellSearch(R). Progression-free survival (PFS) and overall survival (OS) were compared with Log-Rank test between groups, according to CTC count ( (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4969768 Wed, 22 Jun 2011 23:00:00 +0100 4969768 http://www.medworm.com/index.php?rid=4954056&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR66 Conclusions: The results suggest that sunitinib might be beneficial for the treatment of breast cancer by suppressing lymphangiogenesis and lymph node metastasis, through inhibition, particularly importantly, of VEGFR-3. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4954056 Mon, 20 Jun 2011 23:00:00 +0100 4954056 http://www.medworm.com/index.php?rid=4946238&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR64 Conclusions: Comorbid conditions contribute importantly to both total mortality and breast cancer-specific mortality among breast cancer survivors. Attention to reducing the risk of cardiovascular disease should be a priority for the long-term care of women following diagnosis and treatment of breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4946238 Sun, 19 Jun 2011 23:00:00 +0100 4946238 http://www.medworm.com/index.php?rid=4946237&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR65 Conclusions: These findings reveal a novel mechanism of Jab1 gene regulation and provide functional and mechanistic links between the Src/Stat3 and IL-6/Stat3 signaling axes that are involved in the activation of Jab1 transcription and regulation of this novel oncogenic protein. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4946237 Sun, 19 Jun 2011 23:00:00 +0100 4946237 http://www.medworm.com/index.php?rid=4936063&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR63 Conclusions: Taken together, results from this study demonstrate for the first time that Notch-1 and Notch-4 are novel transcriptional targets of PEA3 in breast cancer cells. Targeting of PEA3 and/or Notch pathways might provide a new therapeutic strategy for triple-negative and possibly other breast cancer subtypes. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4936063 Wed, 15 Jun 2011 23:00:00 +0100 4936063 http://www.medworm.com/index.php?rid=4936065&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR61 IntroductionThe detection of circulating tumor cells (CTCs) in the peripheral blood and disseminated tumor cells (DTCs) in the bone marrow are promising prognostic tools for risk stratification in early breast cancer. There is however a need for further validation of these techniques in larger patient cohorts with adequate follow-up periods. Methods: We assayed CTCs and DTCs at primary surgery in 733 stage I/II breast cancer patients with a median follow-up time of 7.6 years. CTCs were detected in samples of peripheral blood mononuclear cells previously stored in liquid-nitrogen using a previously-developed multi-marker quantitative PCR (QPCR)-based assay. DTCs were detected in bone marrow samples by immunocytochemical analysis using anti-cytokeratin antibodies. Results: CTCs were detected... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4936065 Mon, 13 Jun 2011 23:00:00 +0100 4936065 http://www.medworm.com/index.php?rid=4936064&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR62 Conclusions: This study demonstrates differences in microenvironmental conditions in HER2 related subgroups defined by distinct oncogenic pathway activities and provides a mechanistic explanation for differences in the observed hypoxia response between these subgroups. Collectively, these data demonstrate the potential of a pathway-based classification strategy as a framework to integrate genetic and non-genetic factors to investigate the basis of tumor heterogeneity. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4936064 Mon, 13 Jun 2011 23:00:00 +0100 4936064 http://www.medworm.com/index.php?rid=4922990&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F110 Decreased expression of microRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial-mesenchymal transition. An article in the current issue of Breast Cancer Research identify additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4922990 Thu, 09 Jun 2011 23:00:00 +0100 4922990 http://www.medworm.com/index.php?rid=4913073&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F211 Induction of epithelial-to-mesenchymal transition (EMT) in cancer stem cells (CSCs) can occur as the result of embryonic pathway signaling. Activation of Hedgehog (Hh), Wnt, Notch, or TGF-beta leads to the upregulation of a group of transcriptional factors that drive EMT. This process leads to the transformation of adhesive, non-mobile epithelial-like tumor cells into cells with a mobile, invasive phenotype. To investigate the mechanism of metastatic tumor formation in breast cancer, the CSC hypothesis and EMT are key issues to be studied. Both are very closely associated with embryonic signaling pathways that stimulate self-renewal properties of CSC and EMT-inducing transcription factors. Understanding these pathways may lead to new opportunities for therapeutic targets to help prevent me... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4913073 Thu, 09 Jun 2011 23:00:00 +0100 4913073 http://www.medworm.com/index.php?rid=4913072&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F310 As appreciation grows for the contribution of the tumor microenvironment to the progression of cancer, new evidence accumulates to support that the participation of stromal cells can extend beyond the local environment. Recently, Elkabets and colleagues demonstrated a systemic interaction between cancer cells and distant bone marrow cells to support the growth of otherwise indolent tumor cells at a secondary site, raising thought-provoking questions regarding the involvement of stromal cells in maintaining metastatic dormancy. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4913072 Thu, 09 Jun 2011 23:00:00 +0100 4913072 http://www.medworm.com/index.php?rid=4913071&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR59 Conclusions: CTCs expressing Twist and Vimentin, suggestive of an epithelial-mesenchymal transition, are identified in patients with breast cancer. The high incidence of these cells in patients with metastatic disease compared to early stage breast cancer strongly supports the notion that EMT is involved in the metastatic potential of CTCs. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4913071 Thu, 09 Jun 2011 23:00:00 +0100 4913071 http://www.medworm.com/index.php?rid=4913075&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR57 Conclusions: Breast cancer patients carrying the UGT2B7268Tyr/Tyr genotype may benefit most from adjuvant epirubicin-based chemotherapy. These results warrant confirmation in further studies. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4913075 Wed, 08 Jun 2011 23:00:00 +0100 4913075 http://www.medworm.com/index.php?rid=4913074&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR58 This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. Methods: Quantitative real-time PCR (qRT-PCR) and flow cytometry assays were used to detect the expression of genes involved in the sulfation and presentation of chondroitin in several human breast cancer cell lines. Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 (CHST11) and chondroitin sulfate proteoglycan 4 (CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin l... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4913074 Wed, 08 Jun 2011 23:00:00 +0100 4913074 http://www.medworm.com/index.php?rid=4903541&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR56 Conclusions: Telomerase modified the effect of endocrine therapy on breast cancer survivals, suggesting that telomerase may serve as a marker to guide the selection of adjuvant treatment for breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4903541 Sun, 05 Jun 2011 23:00:00 +0100 4903541 http://www.medworm.com/index.php?rid=4894570&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR55 We examined whether plasma C-reactive protein (CRP) levels at the time of diagnosis of breast cancer are associated with overall survival, disease-free survival, death from breast cancer, and recurrence of breast cancer. Methods: We observed 2,910 women for up to seven years after they were diagnosed with invasive breast cancer (median follow-up time was three years). Plasma levels of high-sensitivity CRP were measured at the time of diagnosis and we assessed the association between CRP levels and risk of reduced overall and disease-free survival, death from breast cancer, and recurrence of breast cancer by using the Kaplan-Meier method and Cox proportional hazards regression. During follow-up, 383 women died (225 of whom died from breast cancer) and 118 women experienced recurrence of bre... Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4894570 Thu, 02 Jun 2011 23:00:00 +0100 4894570 http://www.medworm.com/index.php?rid=4884577&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F109 In the previous issue of Breast Cancer Research, Gardner and co-workers describe a novel interaction between Geminin, a protein that prevents reinitiation of DNA replication, and Topoisomerase IIα (TopoIIα), an enzyme essential for removing catenated intertwines between sister chromatids. Geminin facilitates the action of TopoIIα, thereby promoting termination of DNA replication at the same time it inhibits initiation. In this manner, Geminin ensures that cells duplicate their genome once, but only once, each time they divide. Remarkably, either depletion of Geminin or over-expression of Geminin inhibits the action of TopoIIα, thereby making Geminin an excellent target for cancer chemotherapy. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4884577 Tue, 31 May 2011 23:00:00 +0100 4884577 http://www.medworm.com/index.php?rid=4872964&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F209 The Breast International Group (BIG) 1-98 study is a four-arm trial comparing 5 years of monotherapy with tamoxifen or with letrozole or with sequences of 2 years of one followed by 3 years of the other for postmenopausal women with endocrine-responsive early invasive breast cancer. From 1998 to 2003, BIG -98 enrolled 8,010 women. The enhanced design f the trial enabled two complementary analyses of efficacy and safety. Collection of tumor specimens further enabled treatment comparisons based on tumor biology. Reports of BIG 1-98 should be interpreted in relation to each individual patient as she weighs the costs and benefits of available treatments.Clinicaltrials.gov ID: NCT00004205. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4872964 Wed, 25 May 2011 23:00:00 +0100 4872964 http://www.medworm.com/index.php?rid=4872966&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F107 Receptor activator of nuclear factor-κB ligand (RANKL) plays a pivotal role in regulating bone homeostasis. Osteoporosis and malignant bone disease secondary to breast cancer are characterized by enhanced RANKL production and increased bone turnover. Thus, denosumab, a monoclonal antibody to RANKL, has been developed and is now approved for various bone loss conditions. Recent results indicate that RANKL may also promote the development and osseous migration of breast cancer. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4872966 Tue, 24 May 2011 23:00:00 +0100 4872966 http://www.medworm.com/index.php?rid=4872965&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F308 Two recent reports identify ZNF703 as an oncogene driving selection of frequent chromosome 8p12 amplifications in luminal B breast tumors. The estrogen-responsive ZNF703 gene encodes a transcriptional cofactor that, when overexpressed, induces cell proliferation and interferes with transforming growth factor beta signaling. In MCF7 cells, increased ZNF703 expression results in activation of genes involved in stem cell self-renewal - while in primary human mammary epithelial cells, ZNF703 increases the ratio of luminal to basal progenitors. Expression of the murine homolog of ZNF703 reduces cell adhesion and promotes metastasis. ZNF703 overexpression thus alters regulation of proliferation and differentiation in luminal B tumors. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4872965 Tue, 24 May 2011 23:00:00 +0100 4872965 http://www.medworm.com/index.php?rid=4863652&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F108 Not applicable (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4863652 Tue, 24 May 2011 23:00:00 +0100 4863652 http://www.medworm.com/index.php?rid=4853904&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR54 Conclusions: If validated, these findings will bring about a new direction in the design of antibodies whereby different epitopes on the same antibody may be targeted to lead to synergistic/cooperative inhibition and contribute to generate more potent therapeutics and to increase clinical efficacy. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4853904 Sat, 21 May 2011 23:00:00 +0100 4853904 http://www.medworm.com/index.php?rid=4842486&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2F106 Endocrine resistance is a major limitation to the successful treatment of estrogen receptor-positive (ER+) breast cancer and the EGFR and ErbB2 receptor tyrosine kinases are involved in this process. A recent study now implicates the other 2 ErbB family members, ErbB-3 and -4. Exposure of ER+ breast cancer cells to the pure antiestrogen, fulvestrant, increased levels of ErbB-3 or ErbB-4 and sensitivity to the growth stimulatory effects of heregulin beta1, a potent ligand for these receptors. Thus, the initial growth inhibitory effects of fulvestrant appear compromised by cellular plasticity that allows rapid compensatory growth stimulation via ErbB3/4. Further evaluation of pan-erbB receptor inhibitors in endocrine resistant disease appears warranted. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4842486 Thu, 19 May 2011 23:00:00 +0100 4842486 http://www.medworm.com/index.php?rid=4842488&cid=s_31084_6_f&fid=31084&url=http%3A%2F%2Fbreast-cancer-research.com%2Fcontent%2F13%2F3%2FR52 Conclusions: Our data provide the evidence that the IGF-1/IGF-1R signaling axis may play a causal role in anti-estrogen resistance of breast cancer cells, despite continuous suppression of ER transcriptional function by anti-estrogens. (Source: Breast Cancer Research) Breast Cancer Research journals http://www.medworm.com/rss/comments.php?id=4842488 Wed, 18 May 2011 23:00:00 +0100 4842488