MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'British Journal of Dermatology' source. Sun, 21 Mar 2010 14:52:08 +0100 http://www.medworm.com/index.php?rid=3371540&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09695.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3371540 Wed, 17 Mar 2010 00:00:00 +0100 3371540 http://www.medworm.com/index.php?rid=3371542&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09684.x These guidelines for the management of vulvodynia have been prepared by the British Society for the Study of Vulval Diseases Guideline Group. They present evidence-based guidance for treatment, with identification of the strength of evidence available at the time of preparation of the guidelines. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3371542 Tue, 16 Mar 2010 00:00:00 +0100 3371542 http://www.medworm.com/index.php?rid=3371541&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09689.x Conclusion There is some evidence of a higher risk for eczema in urban compared with rural areas, suggesting that place of residence may have a role in the pathogenesis of eczema. Future reviews on environmental circumstances should be carried out to reveal the factors associated with a higher prevalence of eczema in urban areas and the association with other allergic diseases. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3371541 Tue, 16 Mar 2010 00:00:00 +0100 3371541 http://www.medworm.com/index.php?rid=3360534&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09688.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3360534 Sat, 13 Mar 2010 00:00:00 +0100 3360534 http://www.medworm.com/index.php?rid=3360537&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09685.x Conclusions This study shows that mouse eyelashes offer an excellent in vivo model for the quantitative and qualitative analysis of eyelash morphology, development, growth cycle, exogen and pharmacological modulation. This model will help to elucidate the unknown molecular controls of eyelash growth, and to develop novel drugs to treat eyelash disorders. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3360537 Fri, 12 Mar 2010 00:00:00 +0100 3360537 http://www.medworm.com/index.php?rid=3360536&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09686.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3360536 Fri, 12 Mar 2010 00:00:00 +0100 3360536 http://www.medworm.com/index.php?rid=3360535&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09687.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3360535 Fri, 12 Mar 2010 00:00:00 +0100 3360535 http://www.medworm.com/index.php?rid=3355873&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09699.x Conclusions 4-MU is a potent inhibitor of hyaluronan synthesis, induction of stromal hyaluronan accumulation by tumour cells, and fibroblast and melanoma cell proliferation, and results suggest that 4-MU may have potential as a tumour cell anti-invasive and antiproliferative agent. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3355873 Fri, 12 Mar 2010 00:00:00 +0100 3355873 http://www.medworm.com/index.php?rid=3351747&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09677.x Conclusions We confirmed that the condition of multiple syringomas is an autosomal dominant disorder, and we determined the genomic location of the responsible gene. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351747 Thu, 11 Mar 2010 00:00:00 +0100 3351747 http://www.medworm.com/index.php?rid=3351754&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09666.x Conclusions On aggregate, this study suggests that preoperative FD of nodular BCC localized in the H-zone offers no additional benefit to define subclinical tumour infiltration compared with CD alone. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351754 Wed, 10 Mar 2010 00:00:00 +0100 3351754 http://www.medworm.com/index.php?rid=3351753&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09676.x Conclusions Our pilot study shows that two key endocrine controls of pituitary PRL secretion, oestrogen and TRH, also regulate PRL and PRLR expression in human skin. This provides novel insights into the regulation of extrapituitary PRL and PRLR expression, and invites exploration of oestrogen and TRH as novel therapeutic agents in the management of skin and hair diseases characterized by aberrant PRLR-mediated signalling. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351753 Wed, 10 Mar 2010 00:00:00 +0100 3351753 http://www.medworm.com/index.php?rid=3351749&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09665.x Epidermolytic ichthyosis (EI; MIM 113800), previously named bullous congenital ichthyosiform erythroderma or epidermolytic hyperkeratosis, is a rare and clinically variable defect of cornification characterized by generalized erythema, erosions, scaling and easily breaking blisters that become less frequent later in life while hyperkeratosis increases.1 EI is caused by dominant mutations in either KRT1 or KRT10, encoding keratin 1 (K1) and keratin 10 (K10), respectively.1 Usually, mutations are missense substitutions into the highly conserved [alpha]-helical rod domains of the proteins.2,3 However, three inbred pedigrees in which EI is transmitted as a recessive trait due to KRT10 null mutations have been described.4[ndash]6 (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351749 Wed, 10 Mar 2010 00:00:00 +0100 3351749 http://www.medworm.com/index.php?rid=3351748&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09668.x Desmoplakin is the major linker in desmosomes in epithelia and myocardium, anchoring intermediate filaments by the C-terminus to plakoglobin and plakophilin in the desmosomal plaque. Mutations in the gene DSP encoding desmoplakin have been associated with various phenotypes affecting skin and/or heart. One of these phenotypes, lethal acantholytic epidermolysis bullosa (LAEB), is characterized by extensive postnatal shedding of epidermis leading to early demise and is caused by recessive mutations in the gene DSP resulting in truncation of the desmoplakin C-terminus. Here we describe two infants born to the same consanguinous parents who suffered extensive epidermal dislodgment and died shortly after birth. In addition, universal alopecia, anonychia, malformed ears and cardiomyopathy were o... British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351748 Wed, 10 Mar 2010 00:00:00 +0100 3351748 http://www.medworm.com/index.php?rid=3336543&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09669.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336543 Sat, 06 Mar 2010 00:00:00 +0100 3336543 http://www.medworm.com/index.php?rid=3336542&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09674.x Conclusions An IOB provides effective alar anaesthesia in the majority of patients. In those where it is ineffective for complete anaesthesia, an ENB is a useful adjunct. We recommend using an IOB (and ENB if required) prior to direct infiltration of local anaesthetic into the nasal ala to reduce patient discomfort. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336542 Sat, 06 Mar 2010 00:00:00 +0100 3336542 http://www.medworm.com/index.php?rid=3336541&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09682.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336541 Sat, 06 Mar 2010 00:00:00 +0100 3336541 http://www.medworm.com/index.php?rid=3336547&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09667.x Conclusions This study shows the identification of distinct nailfold capillaroscopy patterns in patients with Scl GVHD but it does not confer special risk for any other specific clinical symptoms of the disease. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336547 Fri, 05 Mar 2010 00:00:00 +0100 3336547 http://www.medworm.com/index.php?rid=3336546&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09670.x Conclusions Our study demonstrates that EDARADD mutations are not a frequent cause of HED, while mutations in TRAF6, TAB2 and TAK1 may not be implicated in this disease. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336546 Fri, 05 Mar 2010 00:00:00 +0100 3336546 http://www.medworm.com/index.php?rid=3336545&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09673.x Conclusions This use of teledermoscopy as a triage tool offers the potential to shorten waiting lists and thus improve healthcare access and delivery. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336545 Fri, 05 Mar 2010 00:00:00 +0100 3336545 http://www.medworm.com/index.php?rid=3332673&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09680.x Conclusions Although still to be confirmed in humans, our findings add to the knowledge on turnover rates of circulating and skin-bound autoantibodies in autoimmune bullous dermatoses, which in turn may facilitate a more specific monitoring of these antibodies during the disease course, reduce the need for repeated skin biopsies, and may also be helpful in guiding treatment decisions. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3332673 Fri, 05 Mar 2010 00:00:00 +0100 3332673 http://www.medworm.com/index.php?rid=3332674&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09672.x Conclusions These results suggest that the PV IgG/Dsg3 immune complexes are excluded from the desmosomal core domain rather than directly splitting the desmosome. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3332674 Thu, 04 Mar 2010 00:00:00 +0100 3332674 http://www.medworm.com/index.php?rid=3319336&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09655.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319336 Tue, 02 Mar 2010 00:00:00 +0100 3319336 http://www.medworm.com/index.php?rid=3319353&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09671.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319353 Mon, 01 Mar 2010 00:00:00 +0100 3319353 http://www.medworm.com/index.php?rid=3319351&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09675.x Conclusions Polymorphisms of ss142022671, ss142022677 and ss142022679 in HRH4 are associated with AD. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319351 Mon, 01 Mar 2010 00:00:00 +0100 3319351 http://www.medworm.com/index.php?rid=3319350&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09678.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319350 Mon, 01 Mar 2010 00:00:00 +0100 3319350 http://www.medworm.com/index.php?rid=3319349&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09683.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319349 Mon, 01 Mar 2010 00:00:00 +0100 3319349 http://www.medworm.com/index.php?rid=3319348&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09659.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319348 Mon, 01 Mar 2010 00:00:00 +0100 3319348 http://www.medworm.com/index.php?rid=3319347&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09628.x Conclusions Our observations indicate that African Americans display a limited hypersensitivity following topical capsaicin, compared with the three other ethnic groups. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319347 Mon, 01 Mar 2010 00:00:00 +0100 3319347 http://www.medworm.com/index.php?rid=3319342&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09647.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319342 Mon, 01 Mar 2010 00:00:00 +0100 3319342 http://www.medworm.com/index.php?rid=3319341&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09643.x Conclusions These results support the view that the regular application of moisturizers to normal skin offers a protective effect against repeated exposure to irritants, with no evidence of a reduction in barrier efficiency allowing the easier permeation of irritant substances into the skin as has been suggested by other studies. Regular use of emollient in the healthcare environment may prevent the development of dermatitis. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319341 Mon, 01 Mar 2010 00:00:00 +0100 3319341 http://www.medworm.com/index.php?rid=3319340&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09654.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319340 Mon, 01 Mar 2010 00:00:00 +0100 3319340 http://www.medworm.com/index.php?rid=3319339&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09656.x Conclusions The SADDLE measures activity and damage in patients with DLE. It demonstrates good inter- and excellent intrarater agreement, over and above that for global assessment. It correlates well with global assessment scores. Further studies are required to investigate SADDLE's responsiveness to change with therapy. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319339 Mon, 01 Mar 2010 00:00:00 +0100 3319339 http://www.medworm.com/index.php?rid=3319337&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09649.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319337 Mon, 01 Mar 2010 00:00:00 +0100 3319337 http://www.medworm.com/index.php?rid=3308318&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09658.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308318 Fri, 26 Feb 2010 00:00:00 +0100 3308318 http://www.medworm.com/index.php?rid=3308329&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09626.x Conclusions The results of molecular modelling show relationships between patients' phenotypes and the structural effects of individual mutations. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308329 Thu, 25 Feb 2010 00:00:00 +0100 3308329 http://www.medworm.com/index.php?rid=3308328&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09627.x Conclusions Distinct gene expression profiles in PMBCs define benign and severe clinical entities. Overexpression of endogenous DAMPs in Stevens[ndash]Johnson syndrome and toxic epidermal necrolysis suggest that drugs can trigger the alarmin system in sensitized patients leading to life-threatening diseases. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308328 Thu, 25 Feb 2010 00:00:00 +0100 3308328 http://www.medworm.com/index.php?rid=3308327&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09644.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308327 Thu, 25 Feb 2010 00:00:00 +0100 3308327 http://www.medworm.com/index.php?rid=3308326&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09645.x Conclusions We recommend the use of SSSB for the measurement of Dd as more patients with demodicosis can be diagnosed with this method compared with the DME method. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308326 Thu, 25 Feb 2010 00:00:00 +0100 3308326 http://www.medworm.com/index.php?rid=3308325&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09646.x Xeroderma pigmentosum (XP) is a rare genodermatosis predisposing to skin cancers. The disease is classified into eight groups. Among them, XP group A (XP-A) is characterized by the presence of neurological abnormalities in addition to cutaneous symptoms. In the present study, we report a particular family with XP-A in which some members showed an atypical clinical presentation, i.e. unexplained neurological abnormalities with discrete skin manifestations. Molecular investigation allowed identification of a novel XPA mutation and complete phenotype[ndash]genotype correlation for this new phenotypic expression of XP-A. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308325 Thu, 25 Feb 2010 00:00:00 +0100 3308325 http://www.medworm.com/index.php?rid=3308324&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09648.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308324 Thu, 25 Feb 2010 00:00:00 +0100 3308324 http://www.medworm.com/index.php?rid=3308323&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09650.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308323 Thu, 25 Feb 2010 00:00:00 +0100 3308323 http://www.medworm.com/index.php?rid=3308322&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09651.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308322 Thu, 25 Feb 2010 00:00:00 +0100 3308322 http://www.medworm.com/index.php?rid=3308321&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09652.x Conclusions This is the first study, to our knowledge, to attempt to elucidate the molecular pathogenetic events in podoconiosis. We conclude that TGF-[beta]1 may have a pathogenetic role, with oxidative stress playing a minor role in the early stages of disease. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308321 Thu, 25 Feb 2010 00:00:00 +0100 3308321 http://www.medworm.com/index.php?rid=3308320&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09653.x The H syndrome (OMIM 612391) is a recently described autosomal recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, short stature (low height), hyperglycaemia/diabetes mellitus, hallux valgus, and fixed flexion contractures of the toe and finger joints.1,2 Histologically, there is an inflammatory infiltrate consisting mainly of histiocytes, later replaced by fibrosis of the deep dermis and subcutis.3 In total, 31 patients have been reported in the literature with the clinical phenotype characteristic of this syndrome.1[ndash]7 (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308320 Thu, 25 Feb 2010 00:00:00 +0100 3308320 http://www.medworm.com/index.php?rid=3308319&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09657.x Conclusions Identification of novel mutations and genotype[ndash]phenotype correlations in EBS allow improved understanding of disease pathogenesis as well as better patient management. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3308319 Thu, 25 Feb 2010 00:00:00 +0100 3308319 http://www.medworm.com/index.php?rid=3355877&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09690.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3355877 Mon, 15 Feb 2010 00:00:00 +0100 3355877 http://www.medworm.com/index.php?rid=3355876&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09691.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3355876 Mon, 15 Feb 2010 00:00:00 +0100 3355876 http://www.medworm.com/index.php?rid=3355875&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09692.x Conclusions These findings suggest that tacalcitol reduces skin inflammation by partially downregulating CLA expression levels. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3355875 Mon, 15 Feb 2010 00:00:00 +0100 3355875 http://www.medworm.com/index.php?rid=3355874&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09697.x Conclusions There is little in the way of public health advice concerning the benefits of sun exposure that can be given as an effective means of maintaining adequate vitamin D levels throughout the year. Instead it would seem safer and more effective to fortify more foods with vitamin D and/or to consider the use of supplements during the winter months. Messages concerning sun exposure should remain focused on the detrimental effects of excessive sun exposure and should avoid giving specific advice on what might be 'optimal' sun exposure. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3355874 Mon, 15 Feb 2010 00:00:00 +0100 3355874 http://www.medworm.com/index.php?rid=3241132&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09617.x Conclusions Our study supports the pathogenicity of the keratin 1 L12 domain mutations in vitro. These mutations are associated with a milder EI phenotype with pronounced palmoplantar keratoderma, and without neonatal erythroderma and scaling. The KRT1:p.Asp340Gly mutation in the Dutch families is likely to have arisen from a common founder. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3241132 Fri, 05 Feb 2010 00:00:00 +0100 3241132 http://www.medworm.com/index.php?rid=3355878&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09679.x Conclusions We found MRSA colonizing the anterior nares of a large number of Taiwanese children, especially among those with AD. Analysis of our data provides evidence that links MRSA-colonizing isolates to MRSA-infecting isolates from concurrent SSTI in children with AD. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3355878 Wed, 03 Feb 2010 00:00:00 +0100 3355878 http://www.medworm.com/index.php?rid=3351751&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09661.x We describe female pattern hair loss occurring in a patient with complete androgen insensitivity syndrome suggesting that mechanisms other than direct androgen action contribute to this common form of hair loss in women. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351751 Mon, 01 Feb 2010 00:00:00 +0100 3351751 http://www.medworm.com/index.php?rid=3351750&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09663.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351750 Mon, 01 Feb 2010 00:00:00 +0100 3351750 http://www.medworm.com/index.php?rid=3336548&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09660.x Conclusions This work has identified differentially expressed proteins specific to KS tissue extracts which can potentially be used as specific targets for therapeutic intervention. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336548 Mon, 01 Feb 2010 00:00:00 +0100 3336548 http://www.medworm.com/index.php?rid=3336544&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09664.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3336544 Mon, 01 Feb 2010 00:00:00 +0100 3336544 http://www.medworm.com/index.php?rid=3319352&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09662.x Conclusions IL-1 secretion and the physical contact between keratinocytes and activated, infiltrating T cells may be central for the development of chronic inflammatory skin conditions. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319352 Mon, 01 Feb 2010 00:00:00 +0100 3319352 http://www.medworm.com/index.php?rid=3228895&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09615.x Conclusion These results revealed a genotype[ndash]phenotype correlation in EBS keratinocytes upon heat stress and suggest protein stabilization as a new therapeutic strategy. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3228895 Mon, 01 Feb 2010 00:00:00 +0100 3228895 http://www.medworm.com/index.php?rid=3228894&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09618.x Conclusions Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3228894 Mon, 01 Feb 2010 00:00:00 +0100 3228894 http://www.medworm.com/index.php?rid=3221695&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09619.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3221695 Sat, 30 Jan 2010 00:00:00 +0100 3221695 http://www.medworm.com/index.php?rid=3205963&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09608.x Conclusions RNA interference is a useful tool to evaluate pathogenic mechanisms of M. canis. For the first time, a role in pathogenicity could be attributed to a protease of a dermatophyte, namely Sub3 from M. canis, which is required for adherence to but not for invasion of the epidermis. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3205963 Tue, 26 Jan 2010 00:00:00 +0100 3205963 http://www.medworm.com/index.php?rid=3351752&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09630.x Conclusions An appropriate immunophenotyping validated within the conceptual framework of cutaneous developmental biology allows a logical classification of adnexal neoplasms. Expanding this approach further has the potential to revise the current classification schemes so that not only BCC and pilomatrixoma but all adnexal tumours can be categorized logically. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3351752 Fri, 22 Jan 2010 00:00:00 +0100 3351752 http://www.medworm.com/index.php?rid=3319346&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09629.x Conclusions NB-UVB exposures given on seven consecutive days on different skin areas of healthy women significantly improved serum calcidiol concentration. A short low-dose NB-UVB course can improve vitamin D balance in winter. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319346 Fri, 22 Jan 2010 00:00:00 +0100 3319346 http://www.medworm.com/index.php?rid=3319345&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09639.x Conclusions The system proved to be a useful clinical tool for assessing skin texture. The age-related results may indicate that some skin texture features are formed before the age of 40 years. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319345 Fri, 22 Jan 2010 00:00:00 +0100 3319345 http://www.medworm.com/index.php?rid=3319344&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09640.x Conclusions The prevalence of AGA in Chinese men and women was lower than in Caucasians and similar to that in Koreans. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319344 Fri, 22 Jan 2010 00:00:00 +0100 3319344 http://www.medworm.com/index.php?rid=3319343&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09641.x Conclusions Changes in the epidermal barrier function in patients with CVI are readily detectable by bioengineering methods as early as stage C2 and are manifested by significantly increased TEWL. Our results suggest that the reduced stratum corneum hydration in patients with CVI is due to anatomical differences rather than venous disease. These findings may help better understand the factors contributing to disease progression and its complications. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319343 Fri, 22 Jan 2010 00:00:00 +0100 3319343 http://www.medworm.com/index.php?rid=3319338&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2010.09633.x Conclusions The quantitative reduction of Tregs, together with that of TGF-[beta] and IL-10 serum levels, may be responsible for the loss of tolerance observed in both SSc and morphoea. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3319338 Fri, 22 Jan 2010 00:00:00 +0100 3319338 http://www.medworm.com/index.php?rid=3195154&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09620.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3195154 Fri, 22 Jan 2010 00:00:00 +0100 3195154 http://www.medworm.com/index.php?rid=3195156&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09614.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3195156 Thu, 21 Jan 2010 00:00:00 +0100 3195156 http://www.medworm.com/index.php?rid=3195155&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09616.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3195155 Thu, 21 Jan 2010 00:00:00 +0100 3195155 http://www.medworm.com/index.php?rid=3147127&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09597.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3147127 Thu, 07 Jan 2010 00:00:00 +0100 3147127 http://www.medworm.com/index.php?rid=3109162&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09607.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3109162 Tue, 22 Dec 2009 00:00:00 +0100 3109162 http://www.medworm.com/index.php?rid=3109165&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09599.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3109165 Mon, 21 Dec 2009 00:00:00 +0100 3109165 http://www.medworm.com/index.php?rid=3109164&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09605.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3109164 Mon, 21 Dec 2009 00:00:00 +0100 3109164 http://www.medworm.com/index.php?rid=3109163&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09606.x Conclusion Regression is not an independent predictor of the risk of SLN metastasis in melanoma. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3109163 Mon, 21 Dec 2009 00:00:00 +0100 3109163 http://www.medworm.com/index.php?rid=3102854&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09568.x Conclusions We report five new CT antigens, of which SPATA19 and TEX101 may be possible targets for cancer immunotherapy and novel markers for early detection of BCC. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3102854 Sat, 19 Dec 2009 00:00:00 +0100 3102854 http://www.medworm.com/index.php?rid=3097860&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09602.x Conclusions Castor wax beads constitute a novel nonirritating alternative for abrasive cleaning of recalcitrant oily skin contamination appropriate for individuals with an atopic skin diathesis in a three-step programme of occupational skin protection. As the skin barrier may additionally be influenced by the composition of dirt and use of skin protection and skin care measures under real workplace conditions, this component may now be used and examined further in different occupations. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097860 Fri, 18 Dec 2009 00:00:00 +0100 3097860 http://www.medworm.com/index.php?rid=3097863&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09596.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097863 Thu, 17 Dec 2009 00:00:00 +0100 3097863 http://www.medworm.com/index.php?rid=3097862&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09598.x Conclusions Our results point to the involvement of the TRAF1/C5 locus in the aetiology of familial and severe AA, and provide further support for a shared aetiology between AA and other autoimmune disorders. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097862 Thu, 17 Dec 2009 00:00:00 +0100 3097862 http://www.medworm.com/index.php?rid=3093787&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09563.x Conclusions This study suggests that the development of ANA and anti-dsDNA antibodies on anti-TNF treatment may act as a marker of forthcoming treatment failure. Large-scale prospective studies are required to assess the importance of this observation. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3093787 Thu, 17 Dec 2009 00:00:00 +0100 3093787 http://www.medworm.com/index.php?rid=3080518&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09592.x Conclusion These results raise the possibility that RA binding to cytokeratins in vivo may be involved in the effect of RA on keratinocytes in mouse skin. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3080518 Sat, 12 Dec 2009 00:00:00 +0100 3080518 http://www.medworm.com/index.php?rid=3072838&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09589.x Conclusions Our study suggests that the PREPI is a reliable, valid and responsive measure of body surface area affected by psoriasis that may be useful for future epidemiological research. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3072838 Thu, 10 Dec 2009 00:00:00 +0100 3072838 http://www.medworm.com/index.php?rid=3058001&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09585.x Conclusion: G-CSF has been used for severe neutropenia in TEN, but we recommend and explain why, as in our Chelsea and Westminster protocol, G-CSF should be considered in treating severe TEN irrespective of the severity of neutropenia. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3058001 Sat, 05 Dec 2009 00:00:00 +0100 3058001 http://www.medworm.com/index.php?rid=3049679&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09584.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3049679 Thu, 03 Dec 2009 00:00:00 +0100 3049679 http://www.medworm.com/index.php?rid=3049680&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09582.x Filaggrin is a key protein involved in skin barrier function. Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of ichthyosis vulgaris and have been shown to be major predisposing factors for atopic eczema (AE), initially in European populations. Subsequently, FLG mutations were identified in Japanese, Chinese, Taiwanese and Korean populations. It was demonstrated that FLG mutations are closely associated with AE in the Japanese population. Notably, the same FLG mutations identified in the European population were rarely found in Asians. These results exemplify differences in filaggrin population genetics between Europe and Asia. For mutation screening, background information needs to be obtained on prevalent FLG mutations for each geographical population. It... British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3049680 Wed, 02 Dec 2009 00:00:00 +0100 3049680 http://www.medworm.com/index.php?rid=3045934&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09586.x Conclusions The 5-D, therefore, is a reliable, multidimensional measure of itching that has been validated in patients with chronic pruritus to able to detect changes over time. The 5-D should be useful as an outcome measure in clinical trials. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3045934 Wed, 02 Dec 2009 00:00:00 +0100 3045934 http://www.medworm.com/index.php?rid=3045935&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09581.x Conclusions This study indicates that ERK1/2 and JNK pathways play an important role in the bFGF-mediated effect in HDFs. This study also suggests that controlling ERK1/2 and/or JNK signalling may therefore be a new therapeutic approach for the treatment of chronic and untreatable skin ulcers. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3045935 Tue, 01 Dec 2009 00:00:00 +0100 3045935 http://www.medworm.com/index.php?rid=3041097&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09587.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3041097 Tue, 01 Dec 2009 00:00:00 +0100 3041097 http://www.medworm.com/index.php?rid=3041100&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09579.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3041100 Mon, 30 Nov 2009 00:00:00 +0100 3041100 http://www.medworm.com/index.php?rid=3041099&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09580.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3041099 Mon, 30 Nov 2009 00:00:00 +0100 3041099 http://www.medworm.com/index.php?rid=3041098&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09583.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3041098 Mon, 30 Nov 2009 00:00:00 +0100 3041098 http://www.medworm.com/index.php?rid=3027805&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09557.x Conclusions These results imply that another tumour suppressor gene at this locus may be more important than FOXE1 in skin carcinogenesis and suggest that variation in the FOXE1 polyalanine tract length predisposes to cutaneous SCC. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3027805 Thu, 26 Nov 2009 00:00:00 +0100 3027805 http://www.medworm.com/index.php?rid=3195157&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09603.x Conclusions Double positivity for androgen receptor and 5[alpha]-reductase in Paget cells suggests autocrine synthesis of androgens in extramammary Paget disease. The different hormonal microenvironments in male and female cases and intratumoral androgen levels affect the invasiveness of extramammary Paget disease. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3195157 Wed, 25 Nov 2009 00:00:00 +0100 3195157 http://www.medworm.com/index.php?rid=3097861&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09601.x Conclusions Intralesional vincristine is an effective and safe treatment for nodular lesions in classic Kaposi sarcoma and can be recommended as first-line therapy in initial stages and as support therapy in advanced stages. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097861 Wed, 25 Nov 2009 00:00:00 +0100 3097861 http://www.medworm.com/index.php?rid=3020211&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09511.x Conclusions These results suggested that the ERK, JNK and p38 pathways mediate TGF-[beta]1/Smad signal transduction and might be considered as specific targets of drug therapy for keloids. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3020211 Tue, 24 Nov 2009 00:00:00 +0100 3020211 http://www.medworm.com/index.php?rid=3009834&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09517.x Conclusions We report here the largest series to date of French patients with BHDS. We noted a high prevalence of thyroid nodules and renal cysts. However, the lack of a control group does not allow assessment of whether or not such association with BHDS is fortuitous. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3009834 Fri, 20 Nov 2009 00:00:00 +0100 3009834 http://www.medworm.com/index.php?rid=3205964&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09590.x Conclusions PPC can be an effective treatment for refractory pemphigus but its adverse effects should be considered prior to therapy and closely monitored in patients on treatment. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3205964 Wed, 18 Nov 2009 00:00:00 +0100 3205964 http://www.medworm.com/index.php?rid=3097865&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09591.x Conclusions This study highlights the need for improved standards of regulation of the sunbed industry to protect clients from excessive and dangerous levels of UV radiation in a population where the numbers of melanomas continue to rise. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097865 Wed, 18 Nov 2009 00:00:00 +0100 3097865 http://www.medworm.com/index.php?rid=3097864&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09593.x Conclusions Psoriasis is a common disease in children. Like in adults, it is associated with significant comorbidity. Increased attention should be paid to the early detection and treatment of patients affected. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097864 Wed, 18 Nov 2009 00:00:00 +0100 3097864 http://www.medworm.com/index.php?rid=3080520&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09595.x Many exogenous factors including excessive alcohol consumption have been associated with psoriasis, but the underlying mechanisms still remain elusive. Drinking worsens therapeutic compliance, and decreases the efficacy and increases the toxicity of systemic antipsoriatic treatments. Excess alcohol intake results in compromised immunity and increased risk of infections, but alcohol can induce proinflammatory cytokine production in various cell types and can increase mitogen-derived lymphocyte proliferation and lymphocyte activation. As we have previously reported, alcohol and one of its metabolites, acetone, induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as [alpha]5 integrin, cyclin D1 and keratinocyte growth fac... British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3080520 Wed, 18 Nov 2009 00:00:00 +0100 3080520 http://www.medworm.com/index.php?rid=3072839&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09594.x Conclusions The presence of a parallel-ridge pattern and/or irregular diffuse pigmentation within the lesion is highly indicative of melanoma on volar skin. An irregular lines pattern is the most prominent dermoscopic feature of pigmented ALM of the nail apparatus. Amelanotic ALM either in volar skin or in nail apparatus is characterized by remnants of pigmentation and a polymorphic vascular pattern. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3072839 Wed, 18 Nov 2009 00:00:00 +0100 3072839 http://www.medworm.com/index.php?rid=2997143&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09554.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2997143 Tue, 17 Nov 2009 00:00:00 +0100 2997143 http://www.medworm.com/index.php?rid=2997150&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09553.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2997150 Mon, 16 Nov 2009 00:00:00 +0100 2997150 http://www.medworm.com/index.php?rid=2997149&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09555.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2997149 Mon, 16 Nov 2009 00:00:00 +0100 2997149 http://www.medworm.com/index.php?rid=2997148&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09556.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2997148 Mon, 16 Nov 2009 00:00:00 +0100 2997148 http://www.medworm.com/index.php?rid=2997147&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09558.x Conclusions The prevalence of BRAF V600E in AGN suggests that ultraviolet exposure is not essential for generating the mutation. The BRAF V600E mutational status appears to be of limited diagnostic utility in distinguishing genital naevi that exhibit atypia from those that do not. Similar to oncogenic BRAF-positive common naevi without atypia, enhanced expression of the tumour suppressor IGFBP7 in oncogenic BRAF-positive AGN supports that they are biologically inert. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2997147 Mon, 16 Nov 2009 00:00:00 +0100 2997147 http://www.medworm.com/index.php?rid=2997146&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09559.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2997146 Mon, 16 Nov 2009 00:00:00 +0100 2997146 http://www.medworm.com/index.php?rid=2982581&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09540.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2982581 Thu, 12 Nov 2009 00:00:00 +0100 2982581 http://www.medworm.com/index.php?rid=3205965&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09578.x Conclusions The above data confirm previous reports that treatment with infliximab is an efficacious and safe option for patients with moderate to severe plaque psoriasis (and/or arthritis). Long-term follow-up, continued pharmacovigilance, and controlled comparative studies will be required to fully evaluate its use in the treatment of psoriasis. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3205965 Tue, 10 Nov 2009 00:00:00 +0100 3205965 http://www.medworm.com/index.php?rid=3109166&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09588.x Conclusions A higher prevalence of hypertension in women with AGA has been found. The elevated aldosterone values in these patients may contribute, alongside other mechanisms, to the development of AGA and may also explain the higher prevalence of hypertension. BP screening of women with AGA will permit earlier diagnosis of an unsuspected hypertension and initiation of appropriate treatment. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3109166 Tue, 10 Nov 2009 00:00:00 +0100 3109166 http://www.medworm.com/index.php?rid=3097867&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09574.x Conclusions These results suggest that TXNDC5 gene polymorphisms are associated with the development of NSV in the Korean population. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097867 Tue, 10 Nov 2009 00:00:00 +0100 3097867 http://www.medworm.com/index.php?rid=3097866&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09575.x Conclusions BIOMED-2-GS analysis of the TCR[gamma] gene is as sensitive and specific as DGGE for CTCL diagnosis. In addition, BIOMED-2-GS is less time-consuming and gives more information concerning the size and nature of TCR-GR. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097866 Tue, 10 Nov 2009 00:00:00 +0100 3097866 http://www.medworm.com/index.php?rid=3080522&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09573.x Conclusions Our data on the inflammatory infiltrate of human CL lesions underline the relevance of findings obtained in experimental models. Both Th1 and Tc1 cells appear to be critical for healing in CL in mouse and man. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3080522 Tue, 10 Nov 2009 00:00:00 +0100 3080522 http://www.medworm.com/index.php?rid=3080521&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09577.x Conclusions We underestimated tumour extent at only 4% of margins. Tissue shrinkage was the most important factor affecting eventual histological margin. Our novel technique allowed us to demonstrate that this shrinkage is not uniform across the specimen, but is disproportionately high in the tumour-free margin. This suggests that previous estimates of margin shrinkage, based on whole-specimen contraction measurements, may have been erroneously low. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3080521 Tue, 10 Nov 2009 00:00:00 +0100 3080521 http://www.medworm.com/index.php?rid=3080519&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09576.x Conclusions Data indicate that neoplastic B cells of PBCBL have experienced germinal centre reaction and also suggest that the involvement of IgVH genes is not entirely random in PCBCL and that common antigen epitopes could be pathologically relevant in cutaneous lymphomagenesis. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3080519 Tue, 10 Nov 2009 00:00:00 +0100 3080519 http://www.medworm.com/index.php?rid=3072840&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09572.x Conclusions The majority of patients with CHE who previously achieved 'clear' or 'almost clear' hands following treatment with alitretinoin 30 mg per day also responded to a second course of treatment. Retreatment was well tolerated. Intermittent treatment with alitretinoin is suitable for the long-term management of CHE. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3072840 Tue, 10 Nov 2009 00:00:00 +0100 3072840 http://www.medworm.com/index.php?rid=2974901&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09544.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974901 Tue, 10 Nov 2009 00:00:00 +0100 2974901 http://www.medworm.com/index.php?rid=2974914&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09491.x Conclusions Ustekinumab improves HRQoL in patients with moderate-to-severe psoriasis. Patient-reported outcomes measured a treatment effect beyond that indicated by clinical measures. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974914 Mon, 09 Nov 2009 00:00:00 +0100 2974914 http://www.medworm.com/index.php?rid=2974913&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09495.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974913 Mon, 09 Nov 2009 00:00:00 +0100 2974913 http://www.medworm.com/index.php?rid=2974912&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09496.x In this report, we present an overview of EEC syndrome, discuss the role of TP63 in embryonic development and skin homeostasis, and report five new TP63 gene mutations. We highlight the significant intra- and interfamilial phenotypic variability in affected individuals and outline the emerging paradigm for genotype[ndash]phenotype correlation in this inherited ectodermal dysplasia syndrome. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974912 Mon, 09 Nov 2009 00:00:00 +0100 2974912 http://www.medworm.com/index.php?rid=2974911&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09497.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974911 Mon, 09 Nov 2009 00:00:00 +0100 2974911 http://www.medworm.com/index.php?rid=2974910&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09498.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974910 Mon, 09 Nov 2009 00:00:00 +0100 2974910 http://www.medworm.com/index.php?rid=2974905&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09518.x Conclusions Expression of GR[beta] is increased during topical corticosteroid treatment in the lymphocytes of patients with AD and, in particular, glucocorticoid-insensitive AD is associated with increased expression of GR[beta]. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974905 Mon, 09 Nov 2009 00:00:00 +0100 2974905 http://www.medworm.com/index.php?rid=2974904&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09536.x Conclusions The early inflammatory events (IL-1[alpha] and TNF-[alpha] expression) seen, and the lack of pEGFR in perilesional follicles, indicate that inflammatory events induced by EGFR inhibition may initiate papulopustular eruptions along with the altered differentiations. The decrease of filaggrin may contribute to the pathogenesis of the xerosis caused by cetuximab. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974904 Mon, 09 Nov 2009 00:00:00 +0100 2974904 http://www.medworm.com/index.php?rid=2974903&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09538.x Conclusions Methotrexate may be a useful treatment for steroid-dependent chronic urticaria. Functional autoantibodies do not correlate with response. The beneficial effects of methotrexate may be anti-inflammatory and immunosuppressive. It may therefore benefit chronic urticaria independently of the pathogenic mechanism, whether autoimmune or not. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974903 Mon, 09 Nov 2009 00:00:00 +0100 2974903 http://www.medworm.com/index.php?rid=2974902&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09541.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2974902 Mon, 09 Nov 2009 00:00:00 +0100 2974902 http://www.medworm.com/index.php?rid=2956170&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09542.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2956170 Wed, 04 Nov 2009 00:00:00 +0100 2956170 http://www.medworm.com/index.php?rid=3097868&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09567.x Conclusions These results suggest that the skin can be one of the sources of elevated serum sKDR levels, and that serum sKDR levels are useful for diagnosis and may be a marker of microangiopathy in patients with SSc, especially females. The VEGF-A/KDR signalling system may be involved in the pathogenesis of the disease. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3097868 Tue, 03 Nov 2009 00:00:00 +0100 3097868 http://www.medworm.com/index.php?rid=3080523&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09566.x Conclusion Amniotic membrane immunoblotting is an interesting diagnostic tool for bullous diseases, as the entire panel of autoantibodies can be detected with a single extract. This method improves the identification of complex and heterogeneous autoimmune processes in conjunction with IIF and ELISA, and is particularly useful for MMP characterization. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3080523 Tue, 03 Nov 2009 00:00:00 +0100 3080523 http://www.medworm.com/index.php?rid=2956177&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09494.x Conclusions Signature polymorphisms were observed to be useful for the differentiation of these strains and epidemiological data showed a host specificity among zoophilic strains of T. interdigitale/Arthroderma vanbreuseghemii compared with A. benhamiae as well as characteristic clinical pictures in humans when caused by zoophilic or anthropophilic strains. The delineation is relevant because it helps in determining the correct treatment and provides clues regarding the source of the infection. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2956177 Tue, 03 Nov 2009 00:00:00 +0100 2956177 http://www.medworm.com/index.php?rid=2956176&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09504.x Conclusions Application of the CPX/sol nail lacquer allows rapid nail penetration of CPX, providing CPX levels sufficient to inhibit fungal growth for a prolonged period of time (30 h) after application of lacquer dose. CPX/sol nail lacquer appeared superior to the market reference Loceryl® in terms of both vehicle (hydroxypropyl chitosan) and active ingredient (CPX) as witnessed by its higher efficacy on all nail pathogens. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2956176 Tue, 03 Nov 2009 00:00:00 +0100 2956176 http://www.medworm.com/index.php?rid=2956173&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09519.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2956173 Tue, 03 Nov 2009 00:00:00 +0100 2956173 http://www.medworm.com/index.php?rid=2956172&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09522.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2956172 Tue, 03 Nov 2009 00:00:00 +0100 2956172 http://www.medworm.com/index.php?rid=2956171&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09525.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2956171 Tue, 03 Nov 2009 00:00:00 +0100 2956171 http://www.medworm.com/index.php?rid=2940950&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09516.x Conclusions SCG is effective in reducing pruritus but has no effect on weals, supporting the proposition that, in the skin, SCG inhibits sensory C-fibre nerve activation rather than preventing mast cell degranulation. We suggest that topical SCG treatment, delivered in an appropriate vehicle, may be beneficial for symptomatic relief of pruritus in patients with cutaneous mastocytosis and other pruritic dermatoses. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2940950 Fri, 30 Oct 2009 00:00:00 +0100 2940950 http://www.medworm.com/index.php?rid=2928516&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09543.x We describe a family with AHO and hormone resistance (PHP type Ia) resulting from a rare mutation in GNAS1. The proband presented with small subcutaneous calcifications in the helix of the right ear and concentrated in a sharply demarcated zone of subcutaneous and dermal hypoplasia. This abnormality has so far not been described in patients with AHO. We speculate on the mechanism of dermal hypoplasia and resistance to PTH and suggest that subcutanous or dermal hypoplasia might be another feature which can be present in patients with AHO. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928516 Tue, 27 Oct 2009 00:00:00 +0100 2928516 http://www.medworm.com/index.php?rid=3049681&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09564.x Conclusions This is the first study evaluating the prevalence of HPV types in WTW and the first report of the association between HPV 7 and specific subgroups of patients with warts. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3049681 Mon, 26 Oct 2009 00:00:00 +0100 3049681 http://www.medworm.com/index.php?rid=3045938&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09561.x Conclusions Ciclosporin is significantly more efficacious than prednisolone for severe adult eczema. Despite its frequent use in daily practice, prednisolone is not recommended to induce stable remission of eczema. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3045938 Mon, 26 Oct 2009 00:00:00 +0100 3045938 http://www.medworm.com/index.php?rid=3045937&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09562.x Conclusions Topical PDT induced significant immune suppression, which could impair local antitumour immune responses and may thus contribute to treatment failure. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3045937 Mon, 26 Oct 2009 00:00:00 +0100 3045937 http://www.medworm.com/index.php?rid=3045936&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09565.x The ability of cells to respond to and to mitigate environmental stress is crucial for their survival. Constitutive and facultative pigmentation have evolved in order for human skin to contend with high levels of terrestrial ultraviolet radiation (UVR). When this melanin 'shield' is compromised, individuals are exposed to increased skin cancer risk. The purpose of this review is to discuss new insights into the genetic basis of phenotypic risk factors for skin cancer, their connection to pigmentation and tanning, the precise molecular connections linking UVR to the tanning response, and potential methods of modulating pigmentation that avoid genotoxic damage. Highly translational implications of this research include a scientific basis on which to counsel patients regarding the carcinogeni... British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=3045936 Mon, 26 Oct 2009 00:00:00 +0100 3045936 http://www.medworm.com/index.php?rid=2928528&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09490.x Conclusions i.d. injections of rR9-containing immunogenic Ag without adjuvants simultaneously induce dual immunological effects: the induction of Tc1- and Th1-dominant immune responses, and the induction of inflammatory and CTL-mediated immune responses at the injection area by expressing Ag epitopes on MHC class I molecules as targets. This simple vaccination approach with R9-PTD-containing fusion proteins might be useful as prophylactic immunotherapy for cancer or infectious diseases. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928528 Mon, 26 Oct 2009 00:00:00 +0100 2928528 http://www.medworm.com/index.php?rid=2928527&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09492.x Conclusions The results obtained showed that field therapy with ALA-PDT confers a significant preventive potential against the formation of new NMSCs in patients with field changes. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928527 Mon, 26 Oct 2009 00:00:00 +0100 2928527 http://www.medworm.com/index.php?rid=2928526&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09493.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928526 Mon, 26 Oct 2009 00:00:00 +0100 2928526 http://www.medworm.com/index.php?rid=2928523&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09520.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928523 Mon, 26 Oct 2009 00:00:00 +0100 2928523 http://www.medworm.com/index.php?rid=2928522&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09521.x Conclusions The modified CDASI is perfectly correlated with the original CDASI. It has equally good concurrent validity with the PGM-overall skin and PGM-activity scales. The CDASI subscores have equally good concurrent validity with the PGM-activity and PGM-damage scales. We suggest that PGMs of skin disease activity and damage should be assessed separately for greater specificity. The modified CDASI is a refined and equally as useful outcome measure. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928522 Mon, 26 Oct 2009 00:00:00 +0100 2928522 http://www.medworm.com/index.php?rid=2928521&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09523.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928521 Mon, 26 Oct 2009 00:00:00 +0100 2928521 http://www.medworm.com/index.php?rid=2928520&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09524.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928520 Mon, 26 Oct 2009 00:00:00 +0100 2928520 http://www.medworm.com/index.php?rid=2928519&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09535.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928519 Mon, 26 Oct 2009 00:00:00 +0100 2928519 http://www.medworm.com/index.php?rid=2928518&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09537.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928518 Mon, 26 Oct 2009 00:00:00 +0100 2928518 http://www.medworm.com/index.php?rid=2928517&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09539.x (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2928517 Mon, 26 Oct 2009 00:00:00 +0100 2928517 http://www.medworm.com/index.php?rid=2921625&cid=s_31732_12_f&fid=31732&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2133.2009.09489.x Conclusions The same degree of sensitization was induced by three exposures to DNCB 10 [mu]g cm[minus]2 as by one exposure to 60 [mu]g cm[minus]2 of DNCB. Thus repeated exposure to low doses of contact sensitizers may increase the sensitizing potency. This must be taken into account in future risk assessments. (Source: British Journal of Dermatology) British Journal of Dermatology journals http://www.medworm.com/rss/comments.php?id=2921625 Fri, 23 Oct 2009 23:00:00 +0100 2921625