Cancer Cell via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cancer Cell' source. Wed, 08 Feb 2012 08:41:19 +0100 Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-κB Pathway in Adult T Cell Leukemia and Other Cancers http://www.medworm.com/index.php?rid=5608044&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900477-6 Makoto Yamagishi, Kazumi Nakano, Ariko Miyake, Tadanori Yamochi, Yayoi Kagami, Akihisa Tsutsumi, Yuka Matsuda, Aiko Sato-Otsubo, Satsuki Muto, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, Toshiki Watanabe. Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA silencing and NF-κB.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608044 Tue, 17 Jan 2012 00:00:00 +0100 5608044 KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma http://www.medworm.com/index.php?rid=5608043&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900475-2 Jianhua Ling, Ya'an Kang, Ruiying Zhao, Qianghua Xia, Dung-Fang Lee, Zhe Chang, Jin Li, Bailu Peng, Jason B. Fleming, Huamin Wang, Jinsong Liu, Ihor R. Lemischka, Mien-Chie Hung, Paul J. Chiao. Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic ductal adenocarcinoma (PDAC). However, how NF-κB is activated in PDAC is not yet understood. Here, we re.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608043 Tue, 17 Jan 2012 00:00:00 +0100 5608043 CREPT Accelerates Tumorigenesis by Regulating the Transcription of Cell-Cycle-Related Genes http://www.medworm.com/index.php?rid=5608042&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900478-8 Dongdong Lu, Yinyuan Wu, Yinyin Wang, Fangli Ren, Dianjun Wang, Fuqin Su, Yanquan Zhang, Xi Yang, Guihua Jin, Xinbao Hao, Dacheng He, Yonggong Zhai, David M. Irwin, Jim Hu, Joseph J.Y. Sung, Jun Yu, Baoqing Jia, Zhijie Chang. Tumorigenesis is caused by an uncontrolled cell cycle and the altered expression of many genes. Here, we report a gene CREPT that is preferentially expressed in diverse human tumors. Overex.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608042 Tue, 17 Jan 2012 00:00:00 +0100 5608042 Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs http://www.medworm.com/index.php?rid=5608041&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900446-6 Astrid A.M. Van der Veldt, Mark Lubberink, Idris Bahce, Maudy Walraven, Michiel P. de Boer, Henri N.J.M. Greuter, N. Harry Hendrikse, Jonas Eriksson, Albert D. Windhorst, Pieter E. Postmus, Henk M. Verheul, Erik H. Serné, Adriaan A. Lammertsma, Egbert F. Smit. Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, transiently normali.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608041 Tue, 17 Jan 2012 00:00:00 +0100 5608041 Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway http://www.medworm.com/index.php?rid=5608040&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900447-8 Vesselina G. Cooke, Valerie S. LeBleu, Doruk Keskin, Zainab Khan, Joyce T. O'Connell, Yingqi Teng, Michael B. Duncan, Liang Xie, Genta Maeda, Sylvia Vong, Hikaru Sugimoto, Rafael M. Rocha, Aline Damascena, Ricardo R. Brentani, Raghu Kalluri. The functional role of pericytes in cancer progression remains unknown. Clinical studies suggest that low numbers of vessel-associated pericytes correlated with a drop in overall survival of patie.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608040 Tue, 17 Jan 2012 00:00:00 +0100 5608040 Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success http://www.medworm.com/index.php?rid=5608039&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900440-5 Cristina Branco-Price, Na Zhang, Moritz Schnelle, Colin Evans, Dörthe M. Katschinski, Debbie Liao, Lesley Ellies, Randall S. Johnson. The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how end.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608039 Tue, 17 Jan 2012 00:00:00 +0100 5608039 Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia http://www.medworm.com/index.php?rid=5608038&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900474-0 Michael Quante, Govind Bhagat, Julian A. Abrams, Frederic Marache, Pamela Good, Michele D. Lee, Yoomi Lee, Richard Friedman, Samuel Asfaha, Zinaida Dubeykovskaya, Umar Mahmood, Jose-Luiz Figueiredo, Jan Kitajewski, Carrie Shawber, Charles J. Lightdale, Anil K. Rustgi, Timothy C. Wang. Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression o.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608038 Tue, 17 Jan 2012 00:00:00 +0100 5608038 The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage http://www.medworm.com/index.php?rid=5608037&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900439-9 Madhavsai Gajjar, Marco M. Candeias, Laurence Malbert-Colas, Anne Mazars, Jun Fujita, Vanesa Olivares-Illana, Robin Fåhraeus. The ATM kinase and p53 are key tumor suppressor factors that control the genotoxic stress response pathway. The ATM substrate Mdm2 controls p53 activity by either targeting p53 for degradation or .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608037 Tue, 17 Jan 2012 00:00:00 +0100 5608037 Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma http://www.medworm.com/index.php?rid=5608036&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900473-9 Lindy E. Barrett, Zvi Granot, Courtney Coker, Antonio Iavarone, Dolores Hambardzumyan, Eric C. Holland, Hyung-song Nam, Robert Benezra. Within high-grade gliomas, the precise identities and functional roles of stem-like cells remain unclear. In the normal neurogenic niche, ID (Inhibitor of DNA-binding) genes maintain.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608036 Tue, 17 Jan 2012 00:00:00 +0100 5608036 How to Fool a Wonder Drug: Truncate and Dimerize http://www.medworm.com/index.php?rid=5608035&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900479-X Miriam Molina-Arcas, Julian Downward. In a recent paper, Poulikakos et al. describe a new and potentially common mechanism whereby melanomas develop resistance to the BRAF inhibitor vemurafenib by expressing truncated forms of BRAF(V6.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608035 Tue, 17 Jan 2012 00:00:00 +0100 5608035 Polycomb Regulates NF-κB Signaling in Cancer through miRNA http://www.medworm.com/index.php?rid=5608034&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900481-8 Iris Uribesalgo, Cecilia Ballaré, Luciano Di Croce. The mechanisms leading to the constitutive activation of NF-κB in cancers and the pathways upstream and downstream of this activation are not fully understood. In this issue of Cancer Cell,.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608034 Tue, 17 Jan 2012 00:00:00 +0100 5608034 Mdm2's Dilemma: To Degrade or To Translate p53? http://www.medworm.com/index.php?rid=5608033&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900480-6 Pierre-Jacques Hamard, James J. Manfredi. In this issue of Cancer Cell, Gajjar et al. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608033 Tue, 17 Jan 2012 00:00:00 +0100 5608033 Spheres without Influence: Dissociating In Vitro Self-Renewal from Tumorigenic Potential in Glioma http://www.medworm.com/index.php?rid=5608032&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900476-4 Tracy-Ann Read, Robert J. Wechsler-Reya. The capacity for self-renewal is thought to be a critical property of tumor-initiating cells. This capacity is often associated with the ability to generate spheres in vitro. In this issue of C.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5608032 Tue, 17 Jan 2012 00:00:00 +0100 5608032 Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941 http://www.medworm.com/index.php?rid=5504289&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Ffulltext%2FS1535-6108%2811%2900448-X Teemu T. Junttila, Robert W. Akita, Kathryn Parsons, Carter Fields, Gail D. Lewis Phillips, Lori S. Friedman, Deepak Sampath, Mark X. Sliwkowski. (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504289 Tue, 13 Dec 2011 00:00:00 +0100 5504289 BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance http://www.medworm.com/index.php?rid=5504288&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900438-7 Rinske Drost, Peter Bouwman, Sven Rottenberg, Ute Boon, Eva Schut, Sjoerd Klarenbeek, Christiaan Klijn, Ingrid van der Heijden, Hanneke van der Gulden, Ellen Wientjens, Mark Pieterse, Aurelie Catteau, Pete Green, Ellen Solomon, Joanna R. Morris, Jos Jonkers. Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1C61G mutation in the BRCA1 RING domain is a common pathogenic missense variant, which.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504288 Tue, 13 Dec 2011 00:00:00 +0100 5504288 IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance http://www.medworm.com/index.php?rid=5504287&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900409-0 John B. Mumm, Jan Emmerich, Xueqing Zhang, Ivan Chan, Lingling Wu, Smita Mauze, Steven Blaisdell, Beth Basham, Jie Dai, Jeff Grein, Catherine Sheppard, Kyu Hong, Collette Cutler, Scott Turner, Drake LaFace, Melanie Kleinschek, Michael Judo, Gulesi Ayanoglu, John Langowski, Danling Gu, Brittany Paporello, Erin Murphy, Venkataraman Sriram, Saraswathi Naravula, Bela Desai, Satya Medicherla, Wolfgang Seghezzi, Terrill McClanahan, Susan Cannon-Carlson, Amy M. Beebe, Martin Oft. Tumor immune surveillance and cancer immunotherapies are thought to depend on the intratumoral infiltration of activated CD8+ T cells. Intratumoral CD8+ T cells are rare and .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504287 Tue, 13 Dec 2011 00:00:00 +0100 5504287 WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing http://www.medworm.com/index.php?rid=5504286&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900399-0 Elianna M. Amin, Sebastian Oltean, Jing Hua, Melissa V.R. Gammons, Maryam Hamdollah-Zadeh, Gavin I. Welsh, Man-Kim Cheung, Lan Ni, Satoru Kase, Emma S. Rennel, Kirsty E. Symonds, Dawid G. Nowak, Brigitte Royer-Pokora, Moin A. Saleem, Masatoshi Hagiwara, Valérie A. Schumacher, Steven J. Harper, David R. Hinton, David O. Bates, Michael R. Ladomery. Angiogenesis is regulated by the balance of proangiogenic VEGF165 and antiangiogenic VEGF165b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor gene, supp.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504286 Tue, 13 Dec 2011 00:00:00 +0100 5504286 Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer http://www.medworm.com/index.php?rid=5504285&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900400-4 Kathleen Anders, Christian Buschow, Andreas Herrmann, Ana Milojkovic, Christoph Loddenkemper, Thomas Kammertoens, Peter Daniel, Hua Yu, Jehad Charo, Thomas Blankenstein. The genetic instability of cancer cells frequently causes drug resistance. We established mouse cancer models, which allowed targeting of an oncogene by drug-mediated inactivation or monospecific .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504285 Tue, 13 Dec 2011 00:00:00 +0100 5504285 β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas http://www.medworm.com/index.php?rid=5504284&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900405-3 William E. Damsky, David P. Curley, Manjula Santhanakrishnan, Lara E. Rosenbaum, James T. Platt, Bonnie E. Gould Rothberg, Makoto M. Taketo, David Dankort, David L. Rimm, Martin McMahon, Marcus Bosenberg. Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is f.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504284 Tue, 13 Dec 2011 00:00:00 +0100 5504284 Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia http://www.medworm.com/index.php?rid=5504283&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900410-7 Leisl M. Packer, Sareena Rana, Robert Hayward, Thomas O'Hare, Christopher A. Eide, Ana Rebocho, Sonja Heidorn, Matthew S. Zabriskie, Ion Niculescu-Duvaz, Brian J. Druker, Caroline Springer, Richard Marais. We show that imatinib, nilotinib, and dasatinib possess weak off-target activity against RAF and, therefore, drive paradoxical activation of BRAF and CRAF in a RAS-dependent manner. Critically, be.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504283 Tue, 13 Dec 2011 00:00:00 +0100 5504283 Targeting Liver Cancer: First Steps toward a miRacle? http://www.medworm.com/index.php?rid=5504282&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900444-2 Robert F. Schwabe, Timothy C. Wang. In a recent issue of Cell, Iliopoulos and colleagues demonstrate a novel and targetable epigenetic amplification loop in hepatocellular carcinoma involving HNF4α, miR-124, IL6-R, Stat3, miR.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504282 Tue, 13 Dec 2011 00:00:00 +0100 5504282 Many Tumors in One: A Daunting Therapeutic Prospect http://www.medworm.com/index.php?rid=5504281&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900441-7 Chibawanye I. Ene, Howard A. Fine. In this issue of Cancer Cell, Snuderl and coworkers demonstrate intratumoral genetic heterogeneity in glioblastoma based on in situ amplification of distinct genomic loci within individual .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504281 Tue, 13 Dec 2011 00:00:00 +0100 5504281 “Ring-Fencing” BRCA1 Tumor Suppressor Activity http://www.medworm.com/index.php?rid=5504280&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900442-9 Ketan J. Patel, Gerry P. Crossan, Michael R.G. Hodskinson. BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504280 Tue, 13 Dec 2011 00:00:00 +0100 5504280 Stable IL-10: A New Therapeutic that Promotes Tumor Immunity http://www.medworm.com/index.php?rid=5504279&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900443-0 Michele W.L. Teng, Phillip K. Darcy, Mark J. Smyth. In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated IL-10 increases CD8+ T cell numbers, IFN-γ secretion, and cytotoxicity in established tumors, enhancing antig.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504279 Tue, 13 Dec 2011 00:00:00 +0100 5504279 Metastatic Cells Will Take Any Help They Can Get http://www.medworm.com/index.php?rid=5504278&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900445-4 Richard O. Hynes. Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5504278 Tue, 13 Dec 2011 00:00:00 +0100 5504278 Combined Genetic Inactivation of β2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma http://www.medworm.com/index.php?rid=5468365&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900437-5 We report that diffuse large B cell lymphoma (DLBCL) commonly fails to express cell-surface molecules necessary for the recognition of tumor cells by immune-effector cells. In 29% of cases, mutati.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5468365 Thu, 01 Dec 2011 00:00:00 +0100 5468365 Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma http://www.medworm.com/index.php?rid=5468364&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900436-3 We present an example of genetic heterogeneity in human malignant brain tumors in which mu.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5468364 Thu, 01 Dec 2011 00:00:00 +0100 5468364 VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors http://www.medworm.com/index.php?rid=5468363&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900408-9 Xin Lu, Euphemia Mu, Yong Wei, Sabine Riethdorf, Qifeng Yang, Min Yuan, Jun Yan, Yuling Hua, Benjamin J. Tiede, Xuemin Lu, Bruce G. Haffty, Klaus Pantel, Joan Massagué, Yibin Kang. Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cur.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5468363 Thu, 01 Dec 2011 00:00:00 +0100 5468363 Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia http://www.medworm.com/index.php?rid=5407048&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900398-9 Marko Škrtić, Shrivani Sriskanthadevan, Bozhena Jhas, Marinella Gebbia, Xiaoming Wang, Zezhou Wang, Rose Hurren, Yulia Jitkova, Marcela Gronda, Neil Maclean, Courteney K. Lai, Yanina Eberhard, Justyna Bartoszko, Paul Spagnuolo, Angela C. Rutledge, Alessandro Datti, Troy Ketela, Jason Moffat, Brian H. Robinson, Jessie H. Cameron, Jeffery Wrana, Connie J. Eaves, Mark D. Minden, Jean C.Y. Wang, John E. Dick, Keith Humphries, Corey Nislow, Guri Giaever, Aaron D. Schimmer. To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeas.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407048 Tue, 15 Nov 2011 00:00:00 +0100 5407048 IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development http://www.medworm.com/index.php?rid=5407047&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900396-5 Damien Reynaud, Eric Pietras, Keegan Barry-Holson, Alain Mir, Mikhail Binnewies, Marion Jeanne, Olga Sala-Torra, Jerald P. Radich, Emmanuelle Passegué. Using a mouse model recapitulating the main features of human chronic myelogenous leukemia (CML), we uncover the hierarchy of leukemic stem and progenitor cells contributing to disease pathogenesi.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407047 Tue, 15 Nov 2011 00:00:00 +0100 5407047 The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis http://www.medworm.com/index.php?rid=5407046&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900401-6 Md. Hasan Zaki, Peter Vogel, R.K. Subbarao Malireddi, Mathilde Body-Malapel, Paras K. Anand, John Bertin, Douglas R. Green, Mohamed Lamkanfi, Thirumala-Devi Kanneganti. NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating in.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407046 Tue, 15 Nov 2011 00:00:00 +0100 5407046 Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis http://www.medworm.com/index.php?rid=5407045&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900397-7 Charbel Darido, Smitha R. Georgy, Tomasz Wilanowski, Sebastian Dworkin, Alana Auden, Quan Zhao, Gerhard Rank, Seema Srivastava, Moira J. Finlay, Anthony T. Papenfuss, Pier Paolo Pandolfi, Richard B. Pearson, Stephen M. Jane. Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent tumor supp.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407045 Tue, 15 Nov 2011 00:00:00 +0100 5407045 A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells http://www.medworm.com/index.php?rid=5407044&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900360-6 Lars Anders, Nan Ke, Per Hydbring, Yoon J. Choi, Hans R. Widlund, Joel M. Chick, Huili Zhai, Marc Vidal, Stephen P. Gygi, Pascal Braun, Piotr Sicinski. Cyclin D-dependent kinases (CDK4 and CDK6) are positive regulators of cell cycle entry and they are overactive in the majority of human cancers. However, it is currently not completely understood .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407044 Tue, 15 Nov 2011 00:00:00 +0100 5407044 Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands http://www.medworm.com/index.php?rid=5407043&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900359-X Heather M. O'Hagan, Wei Wang, Subhojit Sen, Christina DeStefano Shields, Stella S. Lee, Yang W. Zhang, Eriko G. Clements, Yi Cai, Leander Van Neste, Hariharan Easwaran, Robert A. Casero, Cynthia L. Sears, Stephen B. Baylin. Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407043 Tue, 15 Nov 2011 00:00:00 +0100 5407043 Altered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia and Identifies Patients at Risk http://www.medworm.com/index.php?rid=5407042&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900358-8 Liang Li, Min Li, Canlan Sun, Liton Francisco, Sujata Chakraborty, Melanie Sabado, Tinisha McDonald, Janelle Gyorffy, Karen Chang, Shirong Wang, Wenhong Fan, Jiangning Li, Lue Ping Zhao, Jerald Radich, Stephen Forman, Smita Bhatia, Ravi Bhatia. Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a major complication of cancer treatment. We compared gene expression in CD34+ cells from patients who developed t-MDS/AML a.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407042 Tue, 15 Nov 2011 00:00:00 +0100 5407042 Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis http://www.medworm.com/index.php?rid=5407041&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900356-4 Myriam Labelle, Shahinoor Begum, Richard O. Hynes. Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression toward metastasis but it is unknown whether additional prometastatic signals a.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407041 Tue, 15 Nov 2011 00:00:00 +0100 5407041 CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis http://www.medworm.com/index.php?rid=5407040&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900355-2 Jiaying Tan, Morgan Jones, Haruhiko Koseki, Manabu Nakayama, Andrew G. Muntean, Ivan Maillard, Jay L. Hess. Chromosomal translocations involving the mixed lineage leukemia (MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is requ.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407040 Tue, 15 Nov 2011 00:00:00 +0100 5407040 Discovery of a Secreted Tumor Suppressor Provides a Promising Therapeutic Strategy for Follicular Lymphoma http://www.medworm.com/index.php?rid=5407039&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900403-X Marc R. Mansour, A. Thomas Look. In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma. A truncated EPHA7TR isoform .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407039 Tue, 15 Nov 2011 00:00:00 +0100 5407039 The Two Faces of NF-κB Signaling in Cancer Development and Therapy http://www.medworm.com/index.php?rid=5407038&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900402-8 Ulf Klein, Sankar Ghosh. Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Developm.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407038 Tue, 15 Nov 2011 00:00:00 +0100 5407038 Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia http://www.medworm.com/index.php?rid=5407037&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900404-1 Marcus Järås, Benjamin L. Ebert. In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding hi.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407037 Tue, 15 Nov 2011 00:00:00 +0100 5407037 Platelets Alter Tumor Cell Attributes to Propel Metastasis: Programming in Transit http://www.medworm.com/index.php?rid=5407036&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900407-7 Laurie J. Gay, Brunhilde Felding-Habermann. Metastasis of epithelial tumors critically depends on acquisition of a disseminating phenotype that allows tumor cells to colonize distant organs. In this issue of Cancer Cell, Labelle et a.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407036 Tue, 15 Nov 2011 00:00:00 +0100 5407036 Collaboration between PcG Proteins and MLL Fusions in Leukemogenesis: An Emerging Paradigm http://www.medworm.com/index.php?rid=5407035&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900406-5 Bernd B. Zeisig, Mari-Francis Arteaga, Cecile Thirant, Chi Wai Eric So. PcG and TrxG proteins mostly with opposite transcriptional activities play key roles in normal and malignant development. In this issue of Cancer Cell, Tan et al. report an unexpected colla.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5407035 Tue, 15 Nov 2011 00:00:00 +0100 5407035 LKB1 and Src: Antagonistic Regulators of Tumor Growth and Metastasis http://www.medworm.com/index.php?rid=5335050&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Ffulltext%2FS1535-6108%2811%2900366-7 Jill Slack-Davis, John O. DaSilva, Sarah J. Parsons. (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335050 Tue, 18 Oct 2011 00:00:00 +0100 5335050 Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs http://www.medworm.com/index.php?rid=5335049&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900357-6 Qing Chen, Xiang H.-F. Zhang, Joan Massagué. Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has remained unknown. W.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335049 Tue, 18 Oct 2011 00:00:00 +0100 5335049 Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling http://www.medworm.com/index.php?rid=5335048&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900354-0 Julie Adam, Emine Hatipoglu, Linda O'Flaherty, Nicola Ternette, Natasha Sahgal, Helen Lockstone, Dilair Baban, Emma Nye, Gordon W. Stamp, Kathryn Wolhuter, Marcus Stevens, Roman Fischer, Peter Carmeliet, Patrick H. Maxwell, Chris W. Pugh, Norma Frizzell, Tomoyoshi Soga, Benedikt M. Kessler, Mona El-Bahrawy, Peter J. Ratcliffe, Patrick J. Pollard. The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It has been propose.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335048 Tue, 18 Oct 2011 00:00:00 +0100 5335048 An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma http://www.medworm.com/index.php?rid=5335047&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900319-9 Aikseng Ooi, Jing-Chii Wong, David Petillo, Douglas Roossien, Victoria Perrier-Trudova, Douglas Whitten, Bernice Wong Hui Min, Min-Han Tan, Zhongfa Zhang, Ximing J. Yang, Ming Zhou, Betty Gardie, Vincent Molinié, Stéphane Richard, Puay Hoon Tan, Bin Tean Teh, Kyle A. Furge. Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma (PRCC2). The main effect of FH mutation is fumarate accumulation. The current paradigm posits.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335047 Tue, 18 Oct 2011 00:00:00 +0100 5335047 The Metabolic Regulator ERRα, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer http://www.medworm.com/index.php?rid=5335046&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900318-7 Ching-yi Chang, Dmitri Kazmin, Jeff S. Jasper, Rebecca Kunder, William J. Zuercher, Donald P. McDonnell. A genomic signature designed to assess the activity of the estrogen-related receptor alpha (ERRα) was used to profile more than 800 breast tumors, revealing a shorter disease-free survival in pati.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335046 Tue, 18 Oct 2011 00:00:00 +0100 5335046 SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity http://www.medworm.com/index.php?rid=5335045&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900352-7 Hyun-Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, Tyler Lahusen, Zhen Xiao, Xiaoling Xu, Cuiling Li, Timothy D. Veenstra, Bing Li, Hongtao Yu, Junfang Ji, Xin Wei Wang, Seong-Hoon Park, Yong I. Cha, David Gius, Chu-Xia Deng. Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in developmen.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335045 Tue, 18 Oct 2011 00:00:00 +0100 5335045 A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies http://www.medworm.com/index.php?rid=5335044&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900351-5 Gabriele Schaefer, Lauric Haber, Lisa M. Crocker, Steven Shia, Lily Shao, Donald Dowbenko, Klara Totpal, Anne Wong, Chingwei V. Lee, Scott Stawicki, Robyn Clark, Carter Fields, Gail D. Lewis Phillips, Rodney A. Prell, Dimitry M. Danilenko, Yvonne Franke, Jean-Philippe Stephan, Jiyoung Hwang, Yan Wu, Jenny Bostrom, Mark X. Sliwkowski, Germaine Fuh, Charles Eigenbrot. Extensive crosstalk among ErbB/HER receptors suggests that blocking signaling from more than one family member may be essential to effectively treat cancer and limit drug resistance. We generated .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335044 Tue, 18 Oct 2011 00:00:00 +0100 5335044 Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1 http://www.medworm.com/index.php?rid=5335043&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900320-5 Changmeng Cai, Housheng Hansen He, Sen Chen, Ilsa Coleman, Hongyun Wang, Zi Fang, Shaoyong Chen, Peter S. Nelson, X. Shirley Liu, Myles Brown, Steven P. Balk. Androgen receptor (AR) is reactivated in castration-resistant prostate cancer (CRPC) through mechanisms including marked increases in AR gene expression. We identify an enhancer in the A.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335043 Tue, 18 Oct 2011 00:00:00 +0100 5335043 Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death http://www.medworm.com/index.php?rid=5335042&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900353-9 Douglas J. Mahoney, Charles Lefebvre, Kristina Allan, Jan Brun, Cina A. Sanaei, Stephen Baird, Nelson Pearce, Susanna Grönberg, Brian Wilson, Mikael Prakesh, Ahmed Aman, Methvin Isaac, Ahmed Mamai, David Uehling, Rima Al-Awar, Theresa Falls, Tommy Alain, David F. Stojdl. To identify therapeutic opportunities for oncolytic viral therapy, we conducted genome-wide RNAi screens to search for host factors that modulate rhabdoviral oncolysis. Our screens uncovered the e.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335042 Tue, 18 Oct 2011 00:00:00 +0100 5335042 FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis http://www.medworm.com/index.php?rid=5335041&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900312-6 Nu Zhang, Ping Wei, Aihua Gong, Wen-Tai Chiu, Hsueh-Te Lee, Howard Colman, He Huang, Jianfei Xue, Mingguang Liu, Yong Wang, Raymond Sawaya, Keping Xie, W.K. Alfred Yung, René H. Medema, Xi He, Suyun Huang. Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335041 Tue, 18 Oct 2011 00:00:00 +0100 5335041 Resistance to EGFR-Targeted Therapy: A Family Affair http://www.medworm.com/index.php?rid=5335040&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900365-5 Gregory Vlacich, Robert J. Coffey. The EGFR-directed antibody cetuximab has proven, albeit modest, clinical benefit as monotherapy in head and neck and colorectal cancers. In a recent study, Yonesaka et al. uncovered a new mechanis.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335040 Tue, 18 Oct 2011 00:00:00 +0100 5335040 The Spliceosome as an Indicted Conspirator in Myeloid Malignancies http://www.medworm.com/index.php?rid=5335039&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900363-1 Omar Abdel-Wahab, Ross Levine. Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335039 Tue, 18 Oct 2011 00:00:00 +0100 5335039 Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2 http://www.medworm.com/index.php?rid=5335038&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900364-3 Lisa Kinch, Nick V. Grishin, James Brugarolas. Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335038 Tue, 18 Oct 2011 00:00:00 +0100 5335038 RAIDDing ER Stress for Oncolytic Viral Therapy http://www.medworm.com/index.php?rid=5335037&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900361-8 David J. McConkey. Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell d.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335037 Tue, 18 Oct 2011 00:00:00 +0100 5335037 Location, Location, Location: FoxM1 Mediates β-Catenin Nuclear Translocation and Promotes Glioma Tumorigenesis http://www.medworm.com/index.php?rid=5335036&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900362-X Angela Bowman, Roel Nusse. Genetic alterations in the Wnt/β-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 med.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5335036 Tue, 18 Oct 2011 00:00:00 +0100 5335036 Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors http://www.medworm.com/index.php?rid=5224635&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900311-4 Thomas De Raedt, Zandra Walton, Jessica L. Yecies, Danan Li, Yimei Chen, Clare F. Malone, Ophélia Maertens, Seung Min Jeong, Roderick T. Bronson, Valerie Lebleu, Raghu Kalluri, Emmanuel Normant, Marcia C. Haigis, Brendan D. Manning, Kwok-Kin Wong, Kay F. Macleod, Karen Cichowski. Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for two Ras-driven cancers: Nf1-deficient malignancies and Kr.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224635 Tue, 13 Sep 2011 00:00:00 +0100 5224635 An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma http://www.medworm.com/index.php?rid=5224634&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900310-2 Jennifer M. Atkinson, Anang A. Shelat, Angel Montero Carcaboso, Tanya A. Kranenburg, Leggy A. Arnold, Nidal Boulos, Karen Wright, Robert A. Johnson, Helen Poppleton, Kumarasamypet M. Mohankumar, Clementine Féau, Timothy Phoenix, Paul Gibson, Liqin Zhu, Yiai Tong, Chris Eden, David W. Ellison, Waldemar Priebe, Dimpy Koul, W. K. Alfred Yung, Amar Gajjar, Clinton F. Stewart, R. Kiplin Guy, Richard J. Gilbertson. Using a mouse model of ependymoma—a chemoresistant brain tumor—we combined multicell high-throughput screening (HTS), kinome-wide binding assays, and in vivo efficacy studies, to identify potentia.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224634 Tue, 13 Sep 2011 00:00:00 +0100 5224634 Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids http://www.medworm.com/index.php?rid=5224633&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900307-2 Jeanine M.L. Roodhart, Laura G.M. Daenen, Edwin C.A. Stigter, Henk-Jan Prins, Johan Gerrits, Julia M. Houthuijzen, Marije G. Gerritsen, Henk S. Schipper, Marieke J.G. Backer, Miranda van Amersfoort, Joost S.P. Vermaat, Petra Moerer, Kenji Ishihara, Eric Kalkhoven, Jos H. Beijnen, Patrick W.B. Derksen, Rene H. Medema, Anton C. Martens, Arjan B. Brenkman, Emile E. Voest. The development of resistance to chemotherapy is a major obstacle for lasting effective treatment of cancer. Here, we demonstrate that endogenous mesenchymal stem cells (MSCs) become activated dur.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224633 Tue, 13 Sep 2011 00:00:00 +0100 5224633 Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL http://www.medworm.com/index.php?rid=5224632&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900266-2 Raghuveer Singh Mali, Baskar Ramdas, Peilin Ma, Jianjian Shi, Veerendra Munugalavadla, Emily Sims, Lei Wei, Sasidhar Vemula, Sarah C. Nabinger, Charles B. Goodwin, Rebecca J. Chan, Fabiola Traina, Valeria Visconte, Ramon V. Tiu, Timothy A. Lewis, Andrew M. Stern, Qiang Wen, John D. Crispino, H. Scott Boswell, Reuben Kapur. We show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL, which is dependent on PI3K and Rho GTPase. Genetic or pharmacologic inhibition of R.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224632 Tue, 13 Sep 2011 00:00:00 +0100 5224632 BikDD Eliminates Breast Cancer Initiating Cells and Synergizes with Lapatinib for Breast Cancer Treatment http://www.medworm.com/index.php?rid=5224630&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900267-4 Jing-Yu Lang, Jennifer L. Hsu, Funda Meric-Bernstam, Chun-Ju Chang, Qingfei Wang, Yi Bao, Hirohito Yamaguchi, Xiaoming Xie, Wendy A. Woodward, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung. Breast cancer initiating cells (BCICs), which can fully recapitulate the tumor origin and are often resistant to chemo- and radiotherapy, are currently considered as a major obstacle for breast ca.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224630 Tue, 13 Sep 2011 00:00:00 +0100 5224630 Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors http://www.medworm.com/index.php?rid=5224629&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900308-4 Sista Sugiarto, Anders I. Persson, Elena Gonzalez Munoz, Markus Waldhuber, Chrystelle Lamagna, Noemi Andor, Patrizia Hanecker, Jennifer Ayers-Ringler, Joanna Phillips, Jason Siu, Daniel A. Lim, Scott Vandenberg, William Stallcup, Mitchel S. Berger, Gabriele Bergers, William A. Weiss, Claudia Petritsch. Postnatal oligodendrocyte progenitor cells (OPC) self-renew, generate mature oligodendrocytes, and are a cellular origin of oligodendrogliomas. We show that the proteoglycan NG2 segregates asymmet.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224629 Tue, 13 Sep 2011 00:00:00 +0100 5224629 The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels http://www.medworm.com/index.php?rid=5224628&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900268-6 Wing-Hang Tong, Carole Sourbier, Gennady Kovtunovych, Suh Young Jeong, Manish Vira, Manik Ghosh, Vladimir Valera Romero, Rachid Sougrat, Sophie Vaulont, Benoit Viollet, Yeong-Sang Kim, Sunmin Lee, Jane Trepel, Ramaprasad Srinivasan, Gennady Bratslavsky, Youfeng Yang, W. Marston Linehan, Tracey A. Rouault. Inactivation of the TCA cycle enzyme, fumarate hydratase (FH), drives a metabolic shift to aerobic glycolysis in FH-deficient kidney tumors and cell lines from patients with heredita.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224628 Tue, 13 Sep 2011 00:00:00 +0100 5224628 Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung http://www.medworm.com/index.php?rid=5224627&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900309-6 Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra. Primary tumors have been shown to prepare distal organs for later colonization of metastatic cells by stimulating organ-specific infiltration of bone marrow derived cells. Here we demonstrate that.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224627 Tue, 13 Sep 2011 00:00:00 +0100 5224627 Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models http://www.medworm.com/index.php?rid=5224626&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900275-3 Ayumu Taguchi, Katerina Politi, Sharon J. Pitteri, William W. Lockwood, Vitor M. Faça, Karen Kelly-Spratt, Chee-Hong Wong, Qing Zhang, Alice Chin, Kwon-Sik Park, Gary Goodman, Adi F. Gazdar, Julien Sage, Daniela M. Dinulescu, Raju Kucherlapati, Ronald A. DePinho, Christopher J. Kemp, Harold E. Varmus, Samir M. Hanash. We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of l.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224626 Tue, 13 Sep 2011 00:00:00 +0100 5224626 Short Hairpin RNA Screen Reveals Bromodomain Proteins as Novel Targets in Acute Myeloid Leukemia http://www.medworm.com/index.php?rid=5224625&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900315-1 Gerd A. Blobel, Anna Kalota, Patricia V. Sanchez, Martin Carroll. Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacolog.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224625 Tue, 13 Sep 2011 00:00:00 +0100 5224625 Tissue States Provide Novel Insights into Attributes that Drive Metastasis http://www.medworm.com/index.php?rid=5224624&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900314-X Thea D. Tlsty. Recently, in Nature Medicine, Schedin and colleagues define attributes within the involuting postpartum breast microenvironment that promote breast cancer metastasis. Cell invasiveness is c.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224624 Tue, 13 Sep 2011 00:00:00 +0100 5224624 DePICTing p53 Activation: A New Nucleolar Link to Cancer http://www.medworm.com/index.php?rid=5224623&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900313-8 Lior Golomb, Moshe Oren. p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224623 Tue, 13 Sep 2011 00:00:00 +0100 5224623 Ras, ROS and Proteotoxic Stress: A Delicate Balance http://www.medworm.com/index.php?rid=5224622&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900316-3 Wanping Xu, Jane Trepel, Len Neckers. Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functio.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224622 Tue, 13 Sep 2011 00:00:00 +0100 5224622 Cancer Biomarkers: Closer to Delivering on their Promise http://www.medworm.com/index.php?rid=5224621&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900317-5 Lance A. Liotta, Emanuel Petricoin. Taguchi et al. describe, in this issue of Cancer Cell, a quantitative comparative biomarker discovery approach that integrates animal lung cancer models with validation in well-controlled h.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5224621 Tue, 13 Sep 2011 00:00:00 +0100 5224621 Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes http://www.medworm.com/index.php?rid=5131659&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Ffulltext%2FS1535-6108%2811%2900273-X Kenneth L. Scott, Cristina Nogueira, Timothy P. Heffernan, Remco van Doorn, Sabin Dhakal, Jason A. Hanna, Chengyin Min, Mariela Jaskelioff, Yonghong Xiao, Chang-Jiun Wu, Lisa A. Cameron, Samuel R. Perry, Rhamy Zeid, Tamar Feinberg, Minjung Kim, George Vande Woude, Scott R. Granter, Marcus Bosenberg, Gerald C. Chu, Ronald A. DePinho, David L. Rimm, Lynda Chin. (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131659 Tue, 16 Aug 2011 00:00:00 +0100 5131659 TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis http://www.medworm.com/index.php?rid=5131658&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Ffulltext%2FS1535-6108%2811%2900274-1 Cyril Quivoron, Lucile Couronné, Véronique Della Valle, Cécile K. Lopez, Isabelle Plo, Orianne Wagner-Ballon, Marcio Do Cruzeiro, Francois Delhommeau, Bertrand Arnulf, Marc-Henri Stern, Lucy Godley, Paule Opolon, Hervé Tilly, Eric Solary, Yannis Duffourd, Philippe Dessen, Hélène Merle-Beral, Florence Nguyen-Khac, Michaëla Fontenay, William Vainchenker, Christian Bastard, Thomas Mercher, Olivier A. Bernard. (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131658 Tue, 16 Aug 2011 00:00:00 +0100 5131658 Coexpression of Normally Incompatible Developmental Pathways in Retinoblastoma Genesis http://www.medworm.com/index.php?rid=5131657&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900261-3 Justina McEvoy, Jacqueline Flores-Otero, Jiakun Zhang, Katie Nemeth, Rachel Brennan, Cori Bradley, Fred Krafcik, Carlos Rodriguez-Galindo, Matthew Wilson, Shunbin Xiong, Guillermina Lozano, Julien Sage, Ligia Fu, Lotfi Louhibi, Jeff Trimarchi, Amar Pani, Richard Smeyne, Dianna Johnson, Michael A. Dyer. It is widely believed that the molecular and cellular features of a tumor reflect its cell of origin and can thus provide clues about treatment targets. The retinoblastoma cell of origin has been .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131657 Tue, 16 Aug 2011 00:00:00 +0100 5131657 Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia http://www.medworm.com/index.php?rid=5131656&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900259-5 We report here that in chronic lymphocytic leukemia (CLL), the propensity to generate clonal B cells has been acquired already at the hematopoietic stem cell (HSC) stage. HSCs purified from patien.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131656 Tue, 16 Aug 2011 00:00:00 +0100 5131656 ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma http://www.medworm.com/index.php?rid=5131655&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900230-3 Victoria Sanz-Moreno, Cedric Gaggioli, Maggie Yeo, Jean Albrengues, Fredrik Wallberg, Amaya Viros, Steven Hooper, Richard Mitter, Chloé C. Féral, Martin Cook, James Larkin, Richard Marais, Guerrino Meneguzzi, Erik Sahai, Chris J. Marshall. Proinflammatory cytokines are frequently observed in the tumor microenvironment, and chronic inflammation is involved in cancer initiation and progression. We show that cytokine signaling through .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131655 Tue, 16 Aug 2011 00:00:00 +0100 5131655 A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression http://www.medworm.com/index.php?rid=5131654&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900263-7 Wei-Chien Yuan, Yu-Ru Lee, Shiu-Feng Huang, Yu-Min Lin, Tzu-Yin Chen, Hsiang-Ching Chung, Chin-Hsien Tsai, Hsin-Yi Chen, Cheng-Ta Chiang, Chun-Kai Lai, Li-Ting Lu, Chun-Hau Chen, De-Leung Gu, Yeong-Shiau Pu, Yuh-Shan Jou, Kun Ping Lu, Pei-Wen Hsiao, Hsiu-Ming Shih, Ruey-Hwa Chen. Tumor hypoxia is associated with disease progression and treatment failure, but the hypoxia signaling mechanism is not fully understood. Here, we show that KLHL20, a Cullin3 (Cul3) substrate adapt.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131654 Tue, 16 Aug 2011 00:00:00 +0100 5131654 Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR http://www.medworm.com/index.php?rid=5131653&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900260-1 Megan P. Hitchins, Robert W. Rapkins, Chau-To Kwok, Sameer Srivastava, Justin J.L. Wong, Levon M. Khachigian, Patsie Polly, Jack Goldblatt, Robyn L. Ward. Constitutional epimutations of tumor suppressor genes manifest as promoter methylation and transcriptional silencing of a single allele in normal somatic tissues, thereby predisposing to cancer. C.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131653 Tue, 16 Aug 2011 00:00:00 +0100 5131653 Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer http://www.medworm.com/index.php?rid=5131652&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900229-7 Qi Cao, Ram-Shankar Mani, Bushra Ateeq, Saravana M. Dhanasekaran, Irfan A. Asangani, John R. Prensner, Jung H. Kim, J. Chad Brenner, Xiaojun Jing, Xuhong Cao, Rui Wang, Yong Li, Arun Dahiya, Lei Wang, Mithil Pandhi, Robert J. Lonigro, Yi-Mi Wu, Scott A. Tomlins, Nallasivam Palanisamy, Zhaohui Qin, Jindan Yu, Christopher A. Maher, Sooryanarayana Varambally, Arul M. Chinnaiyan. Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG) proteins including EZH2, a PRC2 compo.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131652 Tue, 16 Aug 2011 00:00:00 +0100 5131652 Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression http://www.medworm.com/index.php?rid=5131651&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900265-0 Muhan Chen, Christopher P. Pratt, Martha E. Zeeman, Nikolaus Schultz, Barry S. Taylor, Audrey O'Neill, Mireia Castillo-Martin, Dawid G. Nowak, Adam Naguib, Danielle M. Grace, Jernej Murn, Nick Navin, Gurinder S. Atwal, Chris Sander, William L. Gerald, Carlos Cordon-Cardo, Alexandra C. Newton, Brett S. Carver, Lloyd C. Trotman. Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We show that Phlpp1- (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131651 Tue, 16 Aug 2011 00:00:00 +0100 5131651 Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers http://www.medworm.com/index.php?rid=5131650&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900264-9 Timothy R. Wilson, Diana Y. Lee, Leanne Berry, David S. Shames, Jeff Settleman. HER2 kinase inhibitors, such as lapatinib, have demonstrated clinical efficacy in HER2-amplified breast cancers. By profiling nearly 700 human cancer cell lines, we identified a subset of n.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131650 Tue, 16 Aug 2011 00:00:00 +0100 5131650 Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma http://www.medworm.com/index.php?rid=5131649&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900262-5 Hendrik Witt, Stephen C. Mack, Marina Ryzhova, Sebastian Bender, Martin Sill, Ruth Isserlin, Axel Benner, Thomas Hielscher, Till Milde, Marc Remke, David T.W. Jones, Paul A. Northcott, Livia Garzia, Kelsey C. Bertrand, Andrea Wittmann, Yuan Yao, Stephen S. Roberts, Luca Massimi, Tim Van Meter, William A. Weiss, Nalin Gupta, Wiesia Grajkowska, Boleslaw Lach, Yoon-Jae Cho, Andreas von Deimling, Andreas E. Kulozik, Olaf Witt, Gary D. Bader, Cynthia E. Hawkins, Uri Tabori, Abhijit Guha, James T. Rutka, Peter Lichter, Andrey Korshunov, Michael D. Taylor, Stefan M. Pfister. Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcrip.... (Source: C... Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131649 Tue, 16 Aug 2011 00:00:00 +0100 5131649 A TeNaCious Foundation for the Metastatic Niche http://www.medworm.com/index.php?rid=5131648&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900272-8 Irina Matei, Cyrus M. Ghajar, David Lyden. In the July issue of Nature Medicine, Massagué and colleagues define a biphasic role for the extracellular matrix protein tenascin C as a metastatic niche component in lung colonization by .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131648 Tue, 16 Aug 2011 00:00:00 +0100 5131648 We Contain Multitudes: The Protean Face of Retinoblastoma http://www.medworm.com/index.php?rid=5131647&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900270-4 Seth Blackshaw. The precise cellular characteristics of retinoblastoma have long been debated. In this issue of Cancer Cell, McEvoy et al. reveal that retinoblastomas are highly homogeneous at the molecula.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131647 Tue, 16 Aug 2011 00:00:00 +0100 5131647 Surprise! HSC Are Aberrant in Chronic Lymphocytic Leukemia http://www.medworm.com/index.php?rid=5131646&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900269-8 Ash A. Alizadeh, Ravindra Majeti. In this issue of Cancer Cell, Kikushige et al. report the surprising finding that, in human chronic lymphocytic leukemia (CLL), hematopoietic stem cells (HSC) aberrantly generate clonal B c.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131646 Tue, 16 Aug 2011 00:00:00 +0100 5131646 Posterior Fossa Ependymomas: A Tale of Two Subtypes http://www.medworm.com/index.php?rid=5131645&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900271-6 Tenley C. Archer, Scott L. Pomeroy. Ependymomas are common childhood brain tumors, but little is known about their underlying biology. In this issue of Cancer Cell, Witt et al. present that posterior fossa ependymomas compris.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5131645 Tue, 16 Aug 2011 00:00:00 +0100 5131645 Turning Reciprocal Feedback Regulation into Combination Therapy http://www.medworm.com/index.php?rid=5019992&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Ffulltext%2FS1535-6108%2811%2900235-2 Timothy C. Thompson. (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019992 Tue, 12 Jul 2011 00:00:00 +0100 5019992 Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer http://www.medworm.com/index.php?rid=5019991&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900196-6 Min Ni, Yiwen Chen, Elgene Lim, Hallie Wimberly, Shannon T. Bailey, Yuuki Imai, David L. Rimm, X. Shirley Liu, Myles Brown. Endocrine therapies for breast cancer that target the estrogen receptor (ER) are ineffective in the 25%–30% of cases that are ER negative (ER–). Androgen receptor (AR) is expressed in 60%–70% of b.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019991 Tue, 12 Jul 2011 00:00:00 +0100 5019991 miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis http://www.medworm.com/index.php?rid=5019990&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900197-8 Avital Gaziel-Sovran, Miguel F. Segura, Raffaella Di Micco, Mary K. Collins, Douglas Hanniford, Eleazar Vega-Saenz de Miera, John F. Rakus, John F. Dankert, Shulian Shang, Robert S. Kerbel, Nina Bhardwaj, Yongzhao Shao, Farbod Darvishian, Jiri Zavadil, Adrian Erlebacher, Lara K. Mahal, Iman Osman, Eva Hernando. To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019990 Tue, 12 Jul 2011 00:00:00 +0100 5019990 Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes http://www.medworm.com/index.php?rid=5019989&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900195-4 Kenneth L. Scott, Cristina Nogueira, Timothy P. Heffernan, Remco van Doorn, Sabin Dhakal, Jason A. Hanna, Chengyin Min, Mariela Jaskelioff, Yonghong Xiao, Chang-Jiun Wu, Lisa A. Cameron, Samuel R. Perry, Rhamy Zeid, Tamar Feinberg, Minjung Kim, George Vande Woude, Scott R. Granter, Marcus Bosenberg, Gerald C. Chu, Ronald A. DePinho, David L. Rimm, Lynda Chin. Clinical and genomic evidence suggests that the metastatic potential of a primary tumor may be dictated by prometastatic events that have additional oncogenic capability. To test this “determinist.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019989 Tue, 12 Jul 2011 00:00:00 +0100 5019989 A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer http://www.medworm.com/index.php?rid=5019988&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900226-1 Javier E. Girardini, Marco Napoli, Silvano Piazza, Alessandra Rustighi, Carolina Marotta, Enrico Radaelli, Valeria Capaci, Lee Jordan, Phil Quinlan, Alastair Thompson, Miguel Mano, Antonio Rosato, Tim Crook, Eugenio Scanziani, Anthony R. Means, Guillermina Lozano, Claudio Schneider, Giannino Del Sal. TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isome.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019988 Tue, 12 Jul 2011 00:00:00 +0100 5019988 MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L http://www.medworm.com/index.php?rid=5019987&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900228-5 Kathrin M. Bernt, Nan Zhu, Amit U. Sinha, Sridhar Vempati, Joerg Faber, Andrei V. Krivtsov, Zhaohui Feng, Natalie Punt, Amanda Daigle, Lars Bullinger, Roy M. Pollock, Victoria M. Richon, Andrew L. Kung, Scott A. Armstrong. The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We identi.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019987 Tue, 12 Jul 2011 00:00:00 +0100 5019987 Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor http://www.medworm.com/index.php?rid=5019986&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900227-3 Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, Christina R. Majer, Christopher J. Sneeringer, Jeffrey Song, L. Danielle Johnston, Margaret Porter Scott, Jesse J. Smith, Yonghong Xiao, Lei Jin, Kevin W. Kuntz, Richard Chesworth, Mikel P. Moyer, Kathrin M. Bernt, Jen-Chieh Tseng, Andrew L. Kung, Scott A. Armstrong, Robert A. Copeland, Victoria M. Richon, Roy M. Pollock. Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective inhibitor of DOT1L is.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019986 Tue, 12 Jul 2011 00:00:00 +0100 5019986 Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex http://www.medworm.com/index.php?rid=5019985&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900232-7 Michael Heuser, Haiyang Yun, Tobias Berg, Eric Yung, Bob Argiropoulos, Florian Kuchenbauer, Gyeongsin Park, Iyas Hamwi, Lars Palmqvist, Courteney K. Lai, Malina Leung, Grace Lin, Anuhar Chaturvedi, Basant Kumar Thakur, Masayuki Iwasaki, Mikhail Bilenky, Nina Thiessen, Gordon Robertson, Martin Hirst, David Kent, Nicola K. Wilson, Bertie Göttgens, Connie Eaves, Michael L. Cleary, Marco Marra, Arnold Ganser, R. Keith Humphries. Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leuke.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019985 Tue, 12 Jul 2011 00:00:00 +0100 5019985 Beefing up Prostate Cancer Therapy with Performance-Enhancing (Anti-) Steroids http://www.medworm.com/index.php?rid=5019984&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900231-5 William G. Nelson, Michael C. Haffner, Srinivasan Yegnasubramanian. In the May 26th issue of the New England Journal of Medicine, de Bono et al. report that the inhibition of androgen synthesis by abiraterone acetate prolonged the survival of men with prost.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019984 Tue, 12 Jul 2011 00:00:00 +0100 5019984 Comprehensive Identification of Somatic Mutations in Chronic Lymphocytic Leukemia http://www.medworm.com/index.php?rid=5019983&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900234-0 P. Leif Bergsagel, W. Michael Kuehl. Massively parallel sequencing enables the sequencing of whole genomes, exomes, and transcriptomes from many tumor samples. Thus, it now is possible to comprehensively identify somatic mutations, i.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019983 Tue, 12 Jul 2011 00:00:00 +0100 5019983 BCL6: A Novel Target for Therapy of Ph+ B Cell Acute Lymphoblastic Leukemia http://www.medworm.com/index.php?rid=5019982&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900233-9 Richard A. Van Etten. BCL6 is a zinc-finger transcriptional repressor known for its oncogenic role in B cell lymphoma. In a recent issue of Nature, Duy et al. describe a novel role for BCL6 at the center of a tr.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019982 Tue, 12 Jul 2011 00:00:00 +0100 5019982 The Role of TET2 in Hematologic Neoplasms http://www.medworm.com/index.php?rid=5019981&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900236-4 Linda Holmfeldt, Charles G. Mullighan. TET2 encodes an enzyme that hydroxylates methylcytosine and is frequently targeted by loss-of-function mutations in myelodysplasia, myeloproliferative disorders, and acute myeloid leukemia..... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=5019981 Tue, 12 Jul 2011 00:00:00 +0100 5019981 TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis http://www.medworm.com/index.php?rid=4985452&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900225-X We report that i.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4985452 Thu, 30 Jun 2011 00:00:00 +0100 4985452 Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation http://www.medworm.com/index.php?rid=4985451&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900222-4 Kelly Moran-Crusio, Linsey Reavie, Alan Shih, Omar Abdel-Wahab, Delphine Ndiaye-Lobry, Camille Lobry, Maria E. Figueroa, Aparna Vasanthakumar, Jay Patel, Xinyang Zhao, Fabiana Perna, Suveg Pandey, Jozef Madzo, Chunxiao Song, Qing Dai, Chuan He, Sherif Ibrahim, Miloslav Beran, Jiri Zavadil, Stephen D. Nimer, Ari Melnick, Lucy A. Godley, Iannis Aifantis, Ross L. Levine. Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive geneti.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4985451 Thu, 30 Jun 2011 00:00:00 +0100 4985451 CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3 http://www.medworm.com/index.php?rid=4936141&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Ffulltext%2FS1535-6108%2811%2900194-2 Jingqi Chen, Yandan Yao, Chang Gong, Fengyan Yu, Shicheng Su, Jianing Chen, Bodu Liu, Hui Deng, Fengsong Wang, Ling Lin, Herui Yao, Fengxi Su, Karen S. Anderson, Qiang Liu, Mark E. Ewen, Xuebiao Yao, Erwei Song. (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936141 Tue, 14 Jun 2011 00:00:00 +0100 4936141 PI3Kγ Mediates Kaposi's Sarcoma-Associated Herpesvirus vGPCR-Induced Sarcomagenesis http://www.medworm.com/index.php?rid=4936140&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900162-0 Daniel Martin, Rebeca Galisteo, Alfredo A. Molinolo, Reinhard Wetzker, Emilio Hirsch, J. Silvio Gutkind. Angioproliferative tumors induced by the Kaposi's sarcoma-associated herpesvirus (KSHV) have been successfully treated with rapamycin, which provided direct evidence of the clinical activity of mT.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936140 Tue, 14 Jun 2011 00:00:00 +0100 4936140 Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth http://www.medworm.com/index.php?rid=4936139&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900166-8 Michael S. Samuel, Jose I. Lopez, Ewan J. McGhee, Daniel R. Croft, David Strachan, Paul Timpson, June Munro, Ewald Schröder, Jing Zhou, Valerie G. Brunton, Nick Barker, Hans Clevers, Owen J. Sansom, Kurt I. Anderson, Valerie M. Weaver, Michael F. Olson. Tumors and associated stroma manifest mechanical properties that promote cancer. Mechanosensation of tissue stiffness activates the Rho/ROCK pathway to increase actomyosin-mediated cellular tensio.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936139 Tue, 14 Jun 2011 00:00:00 +0100 4936139 Impairment of Cytoplasmic eIF6 Activity Restricts Lymphomagenesis and Tumor Progression without Affecting Normal Growth http://www.medworm.com/index.php?rid=4936137&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900163-2 Annarita Miluzio, Anne Beugnet, Stefano Grosso, Daniela Brina, Marilena Mancino, Stefano Campaner, Bruno Amati, Ario de Marco, Stefano Biffo. Eukaryotic Initiation Factor 6 (eIF6) controls translation by regulating 80S subunit formation. eIF6 is overexpressed in tumors. Here, we demonstrate that eIF6 inactivation delays tumorigenesis an.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936137 Tue, 14 Jun 2011 00:00:00 +0100 4936137 Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung http://www.medworm.com/index.php?rid=4936136&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900167-X Kate D. Sutherland, Natalie Proost, Inge Brouns, Dirk Adriaensen, Ji-Ying Song, Anton Berns. Small cell lung cancer (SCLC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we assessed the effect of Trp53 and Rb1 inactivation.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936136 Tue, 14 Jun 2011 00:00:00 +0100 4936136 Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia http://www.medworm.com/index.php?rid=4936135&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900165-6 Thomas Schmidt, Behzad Kharabi Masouleh, Sonja Loges, Sandra Cauwenberghs, Peter Fraisl, Christa Maes, Bart Jonckx, Kim De Keersmaecker, Maria Kleppe, Marc Tjwa, Thomas Schenk, Stefan Vinckier, Rita Fragoso, Maria De Mol, Karolien Beel, Sérgio Dias, Catherine Verfaillie, Richard E. Clark, Tim H. Brümmendorf, Peter Vandenberghe, Shahin Rafii, Tessa Holyoake, Andreas Hochhaus, Jan Cools, Michael Karin, Geert Carmeliet, Mieke Dewerchin, Peter Carmeliet. Imatinib has revolutionized the treatment of Bcr-Abl1+ chronic myeloid leukemia (CML), but, in mos.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936135 Tue, 14 Jun 2011 00:00:00 +0100 4936135 Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence http://www.medworm.com/index.php?rid=4936134&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900189-9 Carmen Guerra, Manuel Collado, Carolina Navas, Alberto J. Schuhmacher, Isabel Hernández-Porras, Marta Cañamero, Manuel Rodriguez-Justo, Manuel Serrano, Mariano Barbacid. Pancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the most robust oncogenic insults including expression of K-Ras oncogenes and loss of p16Ink4a/p19.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936134 Tue, 14 Jun 2011 00:00:00 +0100 4936134 Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression http://www.medworm.com/index.php?rid=4936133&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900160-7 Michael C. Schmid, Christie J. Avraamides, Holly C. Dippold, Irene Franco, Philippe Foubert, Lesley G. Ellies, Lissette M. Acevedo, Joan R.E. Manglicmot, Xiaodan Song, Wolfgang Wrasidlo, Sara L. Blair, Mark H. Ginsberg, David A. Cheresh, Emilio Hirsch, Seth J. Field, Judith A. Varner. Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We found that a range.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936133 Tue, 14 Jun 2011 00:00:00 +0100 4936133 Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition http://www.medworm.com/index.php?rid=4936132&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900161-9 Juan-Manuel Schvartzman, Pascal H.G. Duijf, Rocio Sotillo, Courtney Coker, Robert Benezra. Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor loss lead to chromosome instability (CIN). It was recently shown that Rb pathway inhibition causes overexpression .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936132 Tue, 14 Jun 2011 00:00:00 +0100 4936132 Turning Reciprocal Feedback Regulation into Combination Therapy http://www.medworm.com/index.php?rid=4936131&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900192-9 Timothy C. Thompson. Two recent Cancer Cell articles report the discovery of reciprocal feedback regulation between androgenic and PTEN loss/PI3K-AKT signaling in prostate cancer. Both studies link endoc.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936131 Tue, 14 Jun 2011 00:00:00 +0100 4936131 ROCK-Driven Actomyosin Contractility Induces Tissue Stiffness and Tumor Growth http://www.medworm.com/index.php?rid=4936130&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900191-7 Sandra Kümper, Christopher J. Marshall. The tumor environment consists of tumor-associated cells, such as macrophages, fibroblasts, and extracellular matrix, and has an important impact on tumor progression. In this issue of Cancer C.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936130 Tue, 14 Jun 2011 00:00:00 +0100 4936130 A Lipid Kinase Cousin Cooperates to Promote Cancer http://www.medworm.com/index.php?rid=4936129&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900190-5 Brandon Beagle, David A. Fruman. Phosphoinositide 3-kinases (PI3Ks) are considered promising drug targets in oncology. In this issue of Cancer Cell, Schmid et al. demonstrate that the PI3Kγ isoform is required for inflamma.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936129 Tue, 14 Jun 2011 00:00:00 +0100 4936129 Oncogene-Induced Mitotic Stress: p53 and pRb Get Mad Too http://www.medworm.com/index.php?rid=4936128&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900193-0 Marcos Malumbres. Oncogenic signaling frequently results in unscheduled overexpression of cell cycle proteins and replicative stress. In this issue of Cancer Cell, Schvartzman et al. show that inactivation o.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4936128 Tue, 14 Jun 2011 00:00:00 +0100 4936128 Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth http://www.medworm.com/index.php?rid=4873019&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900164-4 David J. Mulholland, Linh M. Tran, Yunfeng Li, Houjian Cai, Ashkan Morim, Shunyou Wang, Seema Plaisier, Isla P. Garraway, Jiaoti Huang, Thomas G. Graeber, Hong Wu. Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant prostate cancer (CRPC). However, how PTEN loss is involved in CRPC development is not clear. Here, we show .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4873019 Thu, 26 May 2011 00:00:00 +0100 4873019 CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant http://www.medworm.com/index.php?rid=4830646&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900148-6 Hiroshi Sakamoto, Toshiyuki Tsukaguchi, Sayuri Hiroshima, Tatsushi Kodama, Takamitsu Kobayashi, Takaaki A. Fukami, Nobuhiro Oikawa, Takuo Tsukuda, Nobuya Ishii, Yuko Aoki. Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain cancers, following gene alterations such as chromosomal translocation, amplification, or point mut.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830646 Tue, 17 May 2011 00:00:00 +0100 4830646 Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer http://www.medworm.com/index.php?rid=4830645&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900156-5 J. Chad Brenner, Bushra Ateeq, Yong Li, Anastasia K. Yocum, Qi Cao, Irfan A. Asangani, Sonam Patel, Xiaoju Wang, Hallie Liang, Jindan Yu, Nallasivam Palanisamy, Javed Siddiqui, Wei Yan, Xuhong Cao, Rohit Mehra, Aaron Sabolch, Venkatesha Basrur, Robert J. Lonigro, Jun Yang, Scott A. Tomlins, Christopher A. Maher, Kojo S.J. Elenitoba-Johnson, Maha Hussain, Nora M. Navone, Kenneth J. Pienta, Sooryanarayana Varambally, Felix Y. Feng, Arul M. Chinnaiyan. Recurrent fusions of ETS genes are considered driving mutations in a diverse array of cancers, including Ewing's sarcoma, acute myeloid leukemia, and prostate cancer. We investigate the mechanisms.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830645 Tue, 17 May 2011 00:00:00 +0100 4830645 Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type http://www.medworm.com/index.php?rid=4830644&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900121-8 David H. Nguyen, Hellen A. Oketch-Rabah, Irineu Illa-Bochaca, Felipe C. Geyer, Jorge S. Reis-Filho, Jian-Hua Mao, Shraddha A. Ravani, Jiri Zavadil, Alexander D. Borowsky, D. Joseph Jerry, Karen A. Dunphy, Jae Hong Seo, Sandra Haslam, Daniel Medina, Mary Helen Barcellos-Hoff. Tissue microenvironment is an important determinant of carcinogenesis. We demonstrate that ionizing radiation, a known carcinogen, affects cancer frequency and characteristics by acting on the mic.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830644 Tue, 17 May 2011 00:00:00 +0100 4830644 Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis http://www.medworm.com/index.php?rid=4830643&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900150-4 Emilie A. Bard-Chapeau, Shuangwei Li, Jin Ding, Sharon S. Zhang, Helen H. Zhu, Frederic Princen, Diane D. Fang, Tao Han, Beatrice Bailly-Maitre, Valeria Poli, Nissi M. Varki, Hongyang Wang, Gen-Sheng Feng. The human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Here.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830643 Tue, 17 May 2011 00:00:00 +0100 4830643 Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo http://www.medworm.com/index.php?rid=4830642&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900122-X Joon-Ho Sheen, Roberto Zoncu, Dohoon Kim, David M. Sabatini. Autophagy is of increasing interest as a target for cancer therapy. We find that leucine deprivation causes the caspase-dependent apoptotic death of melanoma cells because it fails to appropriatel.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830642 Tue, 17 May 2011 00:00:00 +0100 4830642 High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/β-Catenin Target Gene, CDC25A http://www.medworm.com/index.php?rid=4830641&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900120-6 Sapna Vijayakumar, Guizhong Liu, Ioana A. Rus, Shen Yao, Yan Chen, Gal Akiri, Luca Grumolato, Stuart A. Aaronson. Wnt canonical signaling is critical for normal development as well as homeostasis of several epithelial tissues, and constitutive activation of this pathway is commonly observed in carcinomas. We .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830641 Tue, 17 May 2011 00:00:00 +0100 4830641 ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma http://www.medworm.com/index.php?rid=4830640&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900149-8 Joanna I. Loizou, Rocio Sancho, Nnennaya Kanu, Daniel J. Bolland, Fengtang Yang, Cristina Rada, Anne E. Corcoran, Axel Behrens. Defective V(D)J rearrangement of immunoglobulin heavy or light chain (IgH or IgL) or class switch recombination (CSR) can initiate chromosomal translocations. The DNA-damage kinase ATM is required.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830640 Tue, 17 May 2011 00:00:00 +0100 4830640 Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer http://www.medworm.com/index.php?rid=4830639&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900155-3 Brett S. Carver, Caren Chapinski, John Wongvipat, Haley Hieronymus, Yu Chen, Sarat Chandarlapaty, Vivek K. Arora, Carl Le, Jason Koutcher, Howard Scher, Peter T. Scardino, Neal Rosen, Charles L. Sawyers. Prostate cancer is characterized by its dependence on androgen receptor (AR) and frequent activation of PI3K signaling. We find that AR transcriptional output is decreased in human and murine tumo.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830639 Tue, 17 May 2011 00:00:00 +0100 4830639 Beyond Hormone Therapy for Prostate Cancer with PARP inhibitors http://www.medworm.com/index.php?rid=4830638&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900159-0 Johann Sebastian de Bono, Shahneen Sandhu, Gerhardt Attard. In this issue of Cancer Cell, Brenner et al. describe that the poly-(ADP) ribose polymerase (PARP) may mediate ERG function and that PARP blockade has antitumor activity in ETS gene-rearran.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830638 Tue, 17 May 2011 00:00:00 +0100 4830638 Identifying the Stroma as a Critical Player in Radiation-Induced Mammary Tumor Development http://www.medworm.com/index.php?rid=4830637&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900157-7 Magdalena A. Cichon, Evette S. Radisky, Derek C. Radisky. Tumor development requires facilitative alterations in the stroma. In this issue of Cancer Cell, Nguyen et al. provide evidence that irradiation of mammary stroma drives accelerated develop.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830637 Tue, 17 May 2011 00:00:00 +0100 4830637 ATMIN: A New Tumor Suppressor in Developing B Cells http://www.medworm.com/index.php?rid=4830636&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900158-9 Xiangyu Liu, Shan Zha. In the current issue of Cancer Cell, Loizou et al. report that the deletion of ATM Interactor (ATMIN) in developing B cells leads to profound genomic instability and clonal B cell leukemia,.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4830636 Tue, 17 May 2011 00:00:00 +0100 4830636 c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma http://www.medworm.com/index.php?rid=4735536&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900147-4 Rafael B. Blasco, Sarah Francoz, David Santamaría, Marta Cañamero, Pierre Dubus, Jean Charron, Manuela Baccarini, Mariano Barbacid. We have investigated the role of individual members of the Raf/Mek/Erk cascade in the onset of K-Ras oncogene-driven non-small cell lung carcinoma (NSCLC). Ablation of Erk1 or Erk2 in K-Ras.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4735536 Thu, 21 Apr 2011 00:00:00 +0100 4735536 Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036 http://www.medworm.com/index.php?rid=4697999&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900092-4 Wayne W. Chan, Scott C. Wise, Michael D. Kaufman, Yu Mi Ahn, Carol L. Ensinger, Torsten Haack, Molly M. Hood, Jennifer Jones, John W. Lord, Wei Ping Lu, David Miller, William C. Patt, Bryan D. Smith, Peter A. Petillo, Thomas J. Rutkoski, Hanumaiah Telikepalli, Lakshminarayana Vogeti, Tony Yao, Lawrence Chun, Robin Clark, Peter Evangelista, L. Cristina Gavrilescu, Katherine Lazarides, Virginia M. Zaleskas, Lance J. Stewart, Richard A. Van Etten, Daniel L. Flynn. Acquired resistance to ABL1 tyrosine kinase inhibitors (TKIs) through ABL1 kinase domain mutations, particularly the gatekeeper mutant T315I, is a significant problem for patients with chronic mye.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697999 Tue, 12 Apr 2011 00:00:00 +0100 4697999 CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3 http://www.medworm.com/index.php?rid=4697998&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900082-1 Jingqi Chen, Yandan Yao, Chang Gong, Fengyan Yu, Shicheng Su, Jianing Chen, Bodu Liu, Hui Deng, Fengsong Wang, Ling Lin, Herui Yao, Fengxi Su, Karen S. Anderson, Qiang Liu, Mark E. Ewen, Xuebiao Yao, Erwei Song. Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis, but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce CCL18, and its expression .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697998 Tue, 12 Apr 2011 00:00:00 +0100 4697998 A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions http://www.medworm.com/index.php?rid=4697997&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900086-9 Chunling Yi, Scott Troutman, Daniela Fera, Anat Stemmer-Rachamimov, Jacqueline L. Avila, Neepa Christian, Nathalie Luna Persson, Akihiko Shimono, David W. Speicher, Ronen Marmorstein, Lars Holmgren, Joseph L. Kissil. The Merlin/NF2 tumor suppressor restrains cell growth and tumorigenesis by controlling contact-dependent inhibition of proliferation. We have identified a tight-junction-associated protein .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697997 Tue, 12 Apr 2011 00:00:00 +0100 4697997 Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells http://www.medworm.com/index.php?rid=4697996&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900081-X Roberta Mazzieri, Ferdinando Pucci, Davide Moi, Erika Zonari, Anna Ranghetti, Alvise Berti, Letterio S. Politi, Bernhard Gentner, Jeffrey L. Brown, Luigi Naldini, Michele De Palma. Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 ligand and angiogen.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697996 Tue, 12 Apr 2011 00:00:00 +0100 4697996 Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3 http://www.medworm.com/index.php?rid=4697995&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900093-6 Olga A. Guryanova, Qiulian Wu, Lin Cheng, Justin D. Lathia, Zhi Huang, Jinbo Yang, Jennifer MacSwords, Christine E. Eyler, Roger E. McLendon, John M. Heddleston, Weinian Shou, Dolores Hambardzumyan, Jeongwu Lee, Anita B. Hjelmeland, Andrew E. Sloan, Markus Bredel, George R. Stark, Jeremy N. Rich, Shideng Bao. Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying ST.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697995 Tue, 12 Apr 2011 00:00:00 +0100 4697995 Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia http://www.medworm.com/index.php?rid=4697994&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900084-5 Irene Homminga, Rob Pieters, Anton W. Langerak, Johan J. de Rooi, Andrew Stubbs, Monique Verstegen, Maartje Vuerhard, Jessica Buijs-Gladdines, Clarissa Kooi, Petra Klous, Pieter van Vlierberghe, Adolfo A. Ferrando, Jean Michel Cayuela, Brenda Verhaaf, H. Berna Beverloo, Martin Horstmann, Valerie de Haas, Anna-Sophia Wiekmeijer, Karin Pike-Overzet, Frank J.T. Staal, Wouter de Laat, Jean Soulier, Francois Sigaux, Jules P.P. Meijerink. To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses includi.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697994 Tue, 12 Apr 2011 00:00:00 +0100 4697994 Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene http://www.medworm.com/index.php?rid=4697993&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900083-3 We report herein tha.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697993 Tue, 12 Apr 2011 00:00:00 +0100 4697993 Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer http://www.medworm.com/index.php?rid=4697992&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900119-X Marina Lesina, Magdalena U. Kurkowski, Katharina Ludes, Stefan Rose-John, Matthias Treiber, Günter Klöppel, Akihiko Yoshimura, Wolfgang Reindl, Bence Sipos, Shizuo Akira, Roland M. Schmid, Hana Algül. Physiological levels of KrasG12D are sufficient to induce pancreatic intraepithelial neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we establ.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697992 Tue, 12 Apr 2011 00:00:00 +0100 4697992 Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression http://www.medworm.com/index.php?rid=4697991&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900091-2 Akihisa Fukuda, Sam C. Wang, John P. Morris, Alexandra E. Folias, Angela Liou, Grace E. Kim, Shizuo Akira, Kenneth M. Boucher, Matthew A. Firpo, Sean J. Mulvihill, Matthias Hebrok. Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and progression in mouse models of the d.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697991 Tue, 12 Apr 2011 00:00:00 +0100 4697991 Resisting Targeted Therapy: Fifty Ways to Leave Your EGFR http://www.medworm.com/index.php?rid=4697990&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900127-9 Paul Workman, Paul A. Clarke. Despite the promise of the new generation of molecularly targeted drugs, intrinsic and acquired resistance is proving to be as problematic as with cytotoxic drugs. Two recent papers have identifie.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697990 Tue, 12 Apr 2011 00:00:00 +0100 4697990 Unswitch-ABL Drugs Overcome Resistance in Chronic Myeloid Leukemia http://www.medworm.com/index.php?rid=4697989&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900126-7 Leisl Packer, Richard Marais. ABL inhibitors have revolutionized the clinical management of chronic myeloid leukemia, but the BCR-ABLT315I mutation confers resistance to currently approved drugs. Chan et al. show, i.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697989 Tue, 12 Apr 2011 00:00:00 +0100 4697989 Chemokines and Cancer: A Fatal Attraction http://www.medworm.com/index.php?rid=4697988&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900124-3 Raffaella Bonecchi, Massimo Locati, Alberto Mantovani. Chemokines are important components of cancer-related inflammation. In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, prom.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697988 Tue, 12 Apr 2011 00:00:00 +0100 4697988 Multiple Effects of Angiopoietin-2 Blockade on Tumors http://www.medworm.com/index.php?rid=4697987&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900123-1 Claire E. Lewis, Napoleone Ferrara. In this issue of Cancer Cell, Mazzieri, Pucci, and colleagues describe the marked effects of inhibiting the proangiogenic cytokine, Angiopoietin-2, on tumor angiogenesis and progression in .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697987 Tue, 12 Apr 2011 00:00:00 +0100 4697987 The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment http://www.medworm.com/index.php?rid=4697986&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900125-5 Ning Li, Sergei I. Grivennikov, Michael Karin. Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three papers in this issue of Cancer Cell demonstrate the importance of tumor-elicited inflammation in the deve.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4697986 Tue, 12 Apr 2011 00:00:00 +0100 4697986 SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization http://www.medworm.com/index.php?rid=4593745&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900085-7 Lydia W.S. Finley, Arkaitz Carracedo, Jaewon Lee, Amanda Souza, Ainara Egia, Jiangwen Zhang, Julie Teruya-Feldstein, Paula I. Moreira, Sandra M. Cardoso, Clary B. Clish, Pier Paolo Pandolfi, Marcia C. Haigis. Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the su.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593745 Tue, 08 Mar 2011 00:00:00 +0100 4593745 Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2−:H2O2 Ratio and Confers Anoikis Resistance to Tumors http://www.medworm.com/index.php?rid=4593744&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900030-4 Pengcheng Zhu, Ming Jie Tan, Royston-Luke Huang, Chek Kun Tan, Han Chung Chong, Mintu Pal, Chee Ren Ivan Lam, Petra Boukamp, Jiun Yit Pan, Suat Hoon Tan, Sander Kersten, Hoi Yeung Li, Jeak Ling Ding, Nguan Soon Tan. Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGP.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593744 Tue, 08 Mar 2011 00:00:00 +0100 4593744 CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth http://www.medworm.com/index.php?rid=4593743&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900050-X Takatsugu Ishimoto, Osamu Nagano, Toshifumi Yae, Mayumi Tamada, Takeshi Motohara, Hiroko Oshima, Masanobu Oshima, Tatsuya Ikeda, Rika Asaba, Hideki Yagi, Takashi Masuko, Takatsune Shimizu, Tomoki Ishikawa, Kazuharu Kai, Eri Takahashi, Yu Imamura, Yoshifumi Baba, Mitsuyo Ohmura, Makoto Suematsu, Hideo Baba, Hideyuki Saya. CD44 is an adhesion molecule expressed in cancer stem-like cells. Here, we show that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the intracellular leve.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593743 Tue, 08 Mar 2011 00:00:00 +0100 4593743 Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis http://www.medworm.com/index.php?rid=4593742&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900048-1 Mark A. Eckert, Thinzar M. Lwin, Andrew T. Chang, Jihoon Kim, Etienne Danis, Lucila Ohno-Machado, Jing Yang. The Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable of promoting the formation of invado.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593742 Tue, 08 Mar 2011 00:00:00 +0100 4593742 The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma http://www.medworm.com/index.php?rid=4593741&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900047-X Shwetal Mehta, Emmanuelle Huillard, Santosh Kesari, Cecile L. Maire, Diane Golebiowski, Emily P. Harrington, John A. Alberta, Michael F. Kane, Matthew Theisen, Keith L. Ligon, David H. Rowitch, Charles D. Stiles. High-grade gliomas are notoriously insensitive to radiation and genotoxic drugs. Paradoxically, the p53 gene is structurally intact in the majority of these tumors. Resistance to genotoxic modalit.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593741 Tue, 08 Mar 2011 00:00:00 +0100 4593741 Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening http://www.medworm.com/index.php?rid=4593740&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900052-3 Eric T. Sawey, Maia Chanrion, Chunlin Cai, Guanming Wu, Jianping Zhang, Lars Zender, Alice Zhao, Ronald W. Busuttil, Herman Yee, Lincoln Stein, Dorothy M. French, Richard S. Finn, Scott W. Lowe, Scott Powers. We screened 124 genes that are amplified in human hepatocellular carcinoma (HCC) using a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 and its neighbor on.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593740 Tue, 08 Mar 2011 00:00:00 +0100 4593740 Matrix Metalloproteinase-2 Conditions Human Dendritic Cells to Prime Inflammatory TH2 Cells via an IL-12- and OX40L-Dependent Pathway http://www.medworm.com/index.php?rid=4593739&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900049-3 Emmanuelle Godefroy, Olivier Manches, Brigitte Dréno, Tsivia Hochman, Linda Rolnitzky, Nathalie Labarrière, Yannick Guilloux, Judith Goldberg, Francine Jotereau, Nina Bhardwaj. Matrix metalloproteinase-2 (MMP-2) is a proteolytic enzyme degrading the extracellular matrix and overexpressed by many tumors. Here, we documented the presence of MMP-2-specific CD4+ T.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593739 Tue, 08 Mar 2011 00:00:00 +0100 4593739 URI Is an Oncogene Amplified in Ovarian Cancer Cells and Is Required for Their Survival http://www.medworm.com/index.php?rid=4593738&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900031-6 Jean-Philippe Theurillat, Stefan Christian Metzler, Nico Henzi, Nabil Djouder, Marianne Helbling, Anna-Kathrin Zimmermann, Francis Jacob, Alex Soltermann, Rosmarie Caduff, Viola Heinzelmann-Schwarz, Holger Moch, Wilhelm Krek. Abrogation of negative feedback control represents a fundamental requirement for aberrantly activated signaling pathways to promote malignant transformation and resistance to therapy. Here we iden.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593738 Tue, 08 Mar 2011 00:00:00 +0100 4593738 Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain http://www.medworm.com/index.php?rid=4593737&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900051-1 Lionel M.L. Chow, Raelene Endersby, Xiaoyan Zhu, Sherri Rankin, Chunxu Qu, Junyuan Zhang, Alberto Broniscer, David W. Ellison, Suzanne J. Baker. Mutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of human glioblastomas. We induced various combinations of deletions in these tumor suppr.... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593737 Tue, 08 Mar 2011 00:00:00 +0100 4593737 Disruptive Events in the Life of Prostate Cancer http://www.medworm.com/index.php?rid=4593736&cid=s_31118_6_f&fid=31118&url=http%3A%2F%2Fwww.cell.com%2Fcancer-cell%2Fabstract%2FS1535-6108%2811%2900089-4 J. Chad Brenner, Arul M. Chinnaiyan. Two recent reports in Nature provide evidence for increasingly complex “disruptive” molecular alterations that occur during prostate cancer progression. They shed light on the intricacy of .... (Source: Cancer Cell) Cancer Cell journals http://www.medworm.com/rss/comments.php?id=4593736 Tue, 08 Mar 2011 00:00:00 +0100 4593736