MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cancer Control' source. Sun, 21 Mar 2010 13:51:58 +0100 http://www.medworm.com/index.php?rid=3383339&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20234193%26dopt%3DAbstract Authors: Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD Tumor metastasis is a leading cause of cancer-related death. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase recruited to integrin-mediated matrix attachment sites where FAK activity is implicated in the control of cell survival, migration and invasion. Although genetic studies support the importance of FAK activity in promoting tumor progression, it remains unclear whether pharmacological FAK inhibition prevents tumor metastasis. Here, we show that the FAK inhibitor PND-1186 blocks FAK Tyr-397 phosphorylation in vivo and exhibits anti-tumor efficacy in orthotopic breast carcinoma mouse tumor models. PND-1186 (100 mg/kg intraperitoneal, i.p.) showe... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3383339 Sat, 20 Mar 2010 00:00:08 +0100 3383339 http://www.medworm.com/index.php?rid=3303487&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20001184%26dopt%3DAbstract CONCLUSIONS: Medication development for the treatment of tobacco dependence remains a scientific and public health priority. PMID: 20001184 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=3303487 Thu, 25 Feb 2010 13:22:10 +0100 3303487 http://www.medworm.com/index.php?rid=3115823&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19760632%26dopt%3DAbstract CONCLUSIONS: CRPCa is the end-stage of a multifactorial and heterogeneous disease process. Pathogenetic factors responsible for the development of the CRPCa phenotype are detectable in the patient's PCa tissue long before the clinical onset of the disease. This approach provides opportunity for early detection and prevention by targeting pathways relevant for the individual disease process. PMID: 19760632 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=3115823 Thu, 24 Dec 2009 04:36:25 +0100 3115823 http://www.medworm.com/index.php?rid=3115822&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20021308%26dopt%3DAbstract Authors: Mittendorf EA, Sharma P Cancer vaccines designed to augment effector T-cell responses have been disappointing with respect to clinical efficacy. This lack of effectiveness may be due to the fact that regulatory mechanisms, both intrinsic and extrinsic to activated T cells, play important roles in inhibiting vaccine-induced effector T-cell responses. This concept raises the possibility that blockade of these regulatory checkpoints might enhance anti-tumor immune responses. In this review, we discuss several regulatory mechanisms that act to control effector T-cell responses and identify strategies to circumvent these mechanisms in order to improve clinical responses. PMID: 20021308 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=3115822 Thu, 24 Dec 2009 04:36:22 +0100 3115822 http://www.medworm.com/index.php?rid=3115821&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20023384%26dopt%3DAbstract Authors: Galluzzi L, Morselli E, Kepp O, Maiuri MC, Kroemer G Autophagy is a finely regulated, lysosomal catabolic pathway that contributes to the turnover of long-lived proteins and to the elimination of old/damaged organelles. Autophagy exerts bona fide oncosuppressive functions by: (1) limiting chromosomal instability; (2) reducing potentially mutagenic oxidative stress; and (3) restraining intratumoral necrosis and local inflammation. Defective autophagy constitutes a hallmark of cancer cells together with: (1) provision of autonomous growth signals;, (2) insensitivity to antiproliferative stimuli; (3) disabled apoptosis; (4) limitless replication; (5) production of angiogenic factors; (6) tissue invasion with metastasis; (7) avoidance of the immune response; and (8) enhanced anabo... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3115821 Thu, 24 Dec 2009 04:36:19 +0100 3115821 http://www.medworm.com/index.php?rid=3115820&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20023427%26dopt%3DAbstract Authors: Varmark H, Kwak S, Theurkauf WE Progression into mitosis in the presence of DNA damage leads to spindle checkpoint (SAC) dependent mitotic delays and cytokinesis failure. In Drosophila embryos, DNA damage does not delay mitotic entry but triggers Checkpoint kinase-2 (Chk2) kinase dependent delays in mitotic exit. It is unclear if damage associated mitotic delays in human cells result from kinase signaling or breaks in centromere DNA that disrupt kinetochore function and activate the SAC. We show that transgenic expression of Human Chk2 in a Drosophila chk2 mutant background restores damage induced mitotic delays during early embryogenesis. Parental HCT116 colorectal cancer cells that progress into mitosis following DNA damage, due to either G(2) checkpoint adaptation or G(2) c... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3115820 Thu, 24 Dec 2009 04:36:16 +0100 3115820 http://www.medworm.com/index.php?rid=3115819&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20023545%26dopt%3DAbstract CONCLUSION: PDGF-BB increases the attraction of hMSCs for gliomas in vitro and in vivo, and this tropism is mediated via PDGF-beta receptors on hMSCs. These findings can be exploited for advancing hMSC treatment. PMID: 20023545 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=3115819 Thu, 24 Dec 2009 04:36:13 +0100 3115819 http://www.medworm.com/index.php?rid=3115818&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025611%26dopt%3DAbstract Authors: Perry JK, Lins RJ, Lobie PE, Mitchell MD Malignant and trophoblastic cells share the capacity to migrate and invade surrounding tissues; however, trophoblast invasion during implantation is tightly regulated, whereas that associated with tumour progression is not. It is likely that similar mechanisms underlie the dynamic regulation of cell invasion and migration in both cases, and that these are based on epigenetic processes. This hypothesis is supported by recent results demonstrating that expression of the intercellular adhesion molecule E-cadherin, deregulation of which is associated with increased cell motility and invasive potential in cancer, is under epigenetic control in trophoblast cell lines. Further elucidation of the epigenetic pathways shared by trophoblasts and m... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3115818 Thu, 24 Dec 2009 04:36:10 +0100 3115818 http://www.medworm.com/index.php?rid=3115817&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20026904%26dopt%3DAbstract Authors: Pickel L, Matsuzuka T, Doi C, Ayuzawa R, Maurya DK, Xie SX, Berkland C, Tamura M The endogenous angiotensin II (Ang II) type 2 receptor (AT(2)) has been shown to mediate apoptosis in cardiovascular tissues. Thus, the aim of this study was to explore the anti-cancer effect of AT(2) overexpression on lung adenocarcinoma cells in vitro using adenoviral (Ad), FuGENE, and nanoparticle vectors. All three gene transfection methods efficiently transfected AT(2) cDNA into lung cancer cells but caused minimal gene transfection in normal lung epithelial cells. Ad-AT(2) significantly attenuated multiple human lung cancer cell growth (A549 and H358) as compared to the control viral vector, Ad-LacZ, when cell viability was examined by direct cell count. Examination of annexin V by flow cyto... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3115817 Thu, 24 Dec 2009 04:36:07 +0100 3115817 http://www.medworm.com/index.php?rid=3067925&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19963131%26dopt%3DAbstract Authors: Maruyama S, Cheng J, Yamazaki M, Zhou XJ, Zhang ZY, He RG, Saku T Overall modes of differential gene expressions were analyzed between human oral/salivary carcinoma cell systems with (MK-1 and ACCM) and without (ZK-1/ZK-2 and ACC2/ACC3) metastatic potential by using micro-array analysis with cancer-associated DNA chips to determine the kinds of genes associated with metastatic behaviors. MK-1 and/or ACCM showed lower levels of gene expression in extracellular matrix-related molecules, such as collagen type IV, laminin, and adhesion molecules such as cadherin 2, but higher levels of genes which control extracellular matrix degradation, such as MMP 9, as well as cell growth and cycle, such as FGF7 and cyclin D1. Among the differentially expressed genes, similar protein expressio... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3067925 Wed, 09 Dec 2009 08:40:13 +0100 3067925 http://www.medworm.com/index.php?rid=3067924&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19963138%26dopt%3DAbstract Authors: Wei BB, Xi B, Wang R, Bai JM, Chang JK, Zhang YY, Yoneda R, Su JT, Hua LX Transforming growth factor-beta1 (TGFbeta1) plays a significant role in regulating cellular proliferation and apoptosis. The TGFbeta1 T29C polymorphism reportedly affects cancer risk, but pertinent studies offer conflicting results. We therefore performed a meta-analysis based on 40 studies from 32 publications, assessing the strength of the association using odds ratios with 95% confidence intervals. Overall, no evidence has indicated that individuals carrying CC or CT genotypes had significantly increased cancer risks, compared with TT genotype carriers [CC vs. TT: odds ratio (OR)=1.10, 95% confidence interval (95% CI)=1.00-1.21, P=0.06; CT vs. TT: OR=1.07, 95% CI=0.99-1.16, P=0.09). However, stratifie... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3067924 Wed, 09 Dec 2009 08:40:10 +0100 3067924 http://www.medworm.com/index.php?rid=3067923&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19966541%26dopt%3DAbstract This study shows for the first time that combinational treatment of tamoxifen and PQ1 (a gap junctional activator) can be used to potentiate apoptosis of T47D human breast cancer cells. Thus, a gap junctional activator, PQ1, could potentially alter either the length or dose of tamoxifen clinically used for breast cancer patients. PMID: 19966541 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=3067923 Wed, 09 Dec 2009 08:40:06 +0100 3067923 http://www.medworm.com/index.php?rid=3052662&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19949929%26dopt%3DAbstract Authors: Harasym TO, Liboiron BD, Mayer LD A newly identified form of multidrug resistance (MDR) in tumor cells is presented, pertaining to the commonly encountered resistance of cancer cells to anticancer drug combinations at discrete drug:drug ratios. In vitro studies have revealed that whether anticancer drug combinations interact synergistically or antagonistically can depend on the ratio of the combined agents. Failure to control drug ratios in vivo due to uncoordinated pharmacokinetics could therefore lead to drug resistance if tumor cells are exposed to antagonistic drug ratios. Consequently, the most efficacious drug combination may not occur at the typically employed maximum tolerated doses of the combined drugs if this leads to antagonistic ratios in vivo after administration... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3052662 Thu, 03 Dec 2009 19:08:11 +0100 3052662 http://www.medworm.com/index.php?rid=3052661&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19953416%26dopt%3DAbstract This study quantified personal work-shift exposures to inhalable dust, endotoxin, and its reactive 3-hydroxy fatty acid (3-OHFA) constituents among workers in grain elevators, cattle feedlots, dairies, and on corn farms. Exposures were compared with post-work-shift nasal lavage fluid inflammation markers and respiratory symptoms. Breathing-zone personal air monitoring was performed over one work shift to quantify inhalable dust (Institute of Medicine samplers), endotoxin (recombinant factor C [rFC] assay), and 3-OHFA (gas chromatography/mass spectrometry). Post-shift nasal lavage fluids were assayed for polymorphonuclear neutrophils (PMN), myeloperoxidase (MPO), interleukin 8 (IL-8), albumin, and eosinophilic cation protein (ECP) concentrations. The geometric mean (GSD) of endotoxin exposu... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3052661 Thu, 03 Dec 2009 19:08:08 +0100 3052661 http://www.medworm.com/index.php?rid=3052660&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19953417%26dopt%3DAbstract Authors: Ho CK, Peng CY, Yang CY To investigate the relationship between air pollution and risk of death from bladder cancer, a matched cancer case-control study was conducted using deaths that occurred in Taiwan from 1997 through 2006. Data for all eligible bladder cancer deaths were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. The control group consisted of individuals who died from causes other than cancer or diseases associated with genitourinary problems. The controls were pair matched to the cases by gender, year of birth, and year of death. Each matched control was selected randomly from the set of possible controls for each case. Data for the number of petrol stations in study municipalities were collected from the two major petrol... Cancer Control journals http://www.medworm.com/rss/comments.php?id=3052660 Thu, 03 Dec 2009 19:08:06 +0100 3052660 http://www.medworm.com/index.php?rid=3045223&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19944277%26dopt%3DAbstract This article describes the CRS/HIPEC technique, and discusses the most common postoperative complications and critical care issues in these patients, including anastomotic leaks, intestinal perforation, abscesses, and intra-abdominal bleeding. The leading cause of mortality is sepsis leading to multiple organ failure, and such patients are at particularly higher risk due to the extensive CRS and HIPEC. The intensivist must be vigilant to ensure that source control is not overlooked. This process is a very difficult one, made even more challenging by the blunting of physiologic responses and the frequent absence of the classic acute abdomen. PMID: 19944277 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=3045223 Tue, 01 Dec 2009 22:44:06 +0100 3045223 http://www.medworm.com/index.php?rid=2955428&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19882130%26dopt%3DAbstract Authors: An HJ, Lebrilla CB Glycosylation is highly sensitive to the biochemical environment and plays a key role in development and disease manifestation. Moreover, glycan biosynthesis depends on several highly competitive processes; thus, variations in the concentration of specific glycosyltransferases produce different products. For this reason, monitoring changes in glycosylation may be a more specific and sensitive approach to biomarker discovery and possibly disease diagnosis. Glycans in serum are of particular interest as approximately half of all proteins are glycosylated. We have developed the methods for profiling the glycans in human serum to identify glycan biomarker. Global release methods were used including chemical and enzymatic to access O-linked and N-linked glycans, ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2955428 Wed, 04 Nov 2009 04:14:09 +0100 2955428 http://www.medworm.com/index.php?rid=2955427&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19882275%26dopt%3DAbstract Authors: Ammerpohl O, Tiwari S, Kalthoff H Target identification of novel therapeutic drugs is pivotal for the establishment of (1) new anticancer regimens, (2) to control side effects of the drugs, and (3) to identify appropriate combinations with established drugs.Here, we describe several in vitro assays applicable to characterize different characteristics of tumor cells. Furthermore, we present a protocol for establishing a reporter gene system for in vivo imaging, allowing for the study of drug effects in small animal models. PMID: 19882275 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2955427 Wed, 04 Nov 2009 04:14:06 +0100 2955427 http://www.medworm.com/index.php?rid=2891280&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19381630%26dopt%3DAbstract CONCLUSION: Weekly docetaxel regimen had good clinical activity with an acceptable toxicity in patients with platinum-refractory SCCHN. PMID: 19381630 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2891280 Wed, 14 Oct 2009 20:06:09 +0100 2891280 http://www.medworm.com/index.php?rid=2856402&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19795350%26dopt%3DAbstract Authors: Araújo FC, Oliveira CA, Reis AB, Del Puerto HL, Martins AS, Reis FM Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and ERbeta proteins in the human testis. Testis tissue samples were obtained from 12 men undergoing orchiectomy as adjuvant treatment for prostate cancer, and were stained by immunohistochemistry for c-fos, phosphorylated c-fos and ERbeta localization. Both forms of c-fos proteins were immunoreactive, mainly in germ cell... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2856402 Sat, 03 Oct 2009 14:16:11 +0100 2856402 http://www.medworm.com/index.php?rid=2709589&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19684468%26dopt%3DAbstract Authors: Bolhassani A, Mohit E, Rafati S Human papillomaviruses (HPVs) are simple, non-enveloped, double-stranded DNA viruses and responsible for an enormous global burden of genital disease. HPV is annually associated with 500,000 new cases of cervical cancer and 250,000 cervical cancer deaths worldwide. The association between HPV infection and cervical cancer indicates that HPV serves as an ideal target for development of preventive and therapeutic vaccines. A novel approach for primary prevention of cervical cancer has become available by the discovery of efficient prophylactic HPV vaccines based on virus-like particles. Therapeutic vaccination has been limited by inadequate antigen-specific immune responses. Different therapeutic strategies have been developed including peptide im... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2709589 Tue, 18 Aug 2009 15:50:06 +0100 2709589 http://www.medworm.com/index.php?rid=2700361&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19184002%26dopt%3DAbstract Authors: Abdel-Motal UM, Wigglesworth K, Galili U alpha-Gal glycolipids capable of converting tumors into endogenous vaccines, have alpha-gal epitopes (Gal alpha 1-3 Gal beta 1-4GlcNAc-R) and are extracted from rabbit RBC membranes. alpha-Gal epitopes bind anti-Gal, the most abundant natural antibody in humans constituting 1% of immunoglobulins. alpha-Gal glycolipids insert into tumor cell membranes, bind anti-Gal and activate complement. The complement cleavage peptides C5a and C3a recruit inflammatory cells and APC into the treated lesion. Anti-Gal further opsonizes the tumor cells and targets them for effective uptake by recruited APC, via Fc gamma receptors. These APC transport internalized tumor cells to draining lymph nodes, and present immunogenic tumor antigen peptides for acti... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2700361 Fri, 14 Aug 2009 23:42:15 +0100 2700361 http://www.medworm.com/index.php?rid=2700360&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19225777%26dopt%3DAbstract In this report, C57BL6 mice were vaccinated with DC pulsed with peptides eluted (EP) from the syngeneic C1498 myelomonocytic leukemic cell line in a prophylactic setting. In this model, a natural antileukemic immunity mediated by NK cells was observed in the control unloaded DC-vaccinated group. On the other hand, we showed that the cytotoxic antileukemic immune response induced by vaccination with eluted peptides pulsed-DC (DC/EP), in vitro and in vivo, was mainly mediated by CD4(+) T cells. Treatment with anti-CD25 antibody to deplete CD4(+) CD25(+) regulatory T cells before DC-vaccination dramatically improved the antileukemic immune response induced by immunization, and allowed the development of long-lasting immune responses that were tumor protective after a re-challenge with leukemi... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2700360 Fri, 14 Aug 2009 23:42:13 +0100 2700360 http://www.medworm.com/index.php?rid=2700359&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19259669%26dopt%3DAbstract In this study, we found that Gö6983, a PKC inhibitor, induced a remarkable increase of NCR expression on primary NK cells, but other PKC inhibitors and NK cell stimulators such as IL-2 and PMA, did not. Gö6983 increased the expression of NCR in a time- and concentration-dependent manner. Furthermore, Gö6983 strongly upregulated the surface expression of death ligands FasL and TRAIL, but not cytotoxic molecules perforin and granzyme B. Unlike two other NK stimulating molecules, IL-2, and PMA, Gö6983 did not induce NK cell proliferation. Up-regulation of NCRs and death ligands on NK cells by Gö6983 resulted in a significant enhancement of NK cytotoxicity against various cancer cell lines. Most importantly, administration of Gö6983 effectively inhibited pulmonary... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2700359 Fri, 14 Aug 2009 23:42:10 +0100 2700359 http://www.medworm.com/index.php?rid=2700358&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19294384%26dopt%3DAbstract CONCLUSION: The relatively specific association of SHP-1 with CD22 suggests that CD22-specific signal augmentation by phosphatase inhibitors can improve the clinical outcome of anti-CD22 based immunotherapy. PMID: 19294384 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2700358 Fri, 14 Aug 2009 23:42:08 +0100 2700358 http://www.medworm.com/index.php?rid=2700357&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19671045%26dopt%3DAbstract Authors: Galbán S, Gorospe M The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor-1) induces angiogenesis, a process that is aberrantly elevated in cancer. The HIF-1 subunit is constitutively expressed, but the levels of the HIF-1 subunit are robustly regulated, increasing under hypoxic conditions and decreasing in normoxia. These changes result from rapid alterations in the rates of HIF-1 production and degradation. While the regulation of HIF-1 degradation is understood in significant detail, much less is known about the regulation of HIF-1 biosynthesis. Here, we review recent evidence that HIF-1 production is effectively controlled by post-transcriptional mechanisms. We focus on the RNA-binding proteins (RBPs) and the non-coding RNAs that interact with the HIF... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2700357 Fri, 14 Aug 2009 23:42:06 +0100 2700357 http://www.medworm.com/index.php?rid=2646574&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19633421%26dopt%3DAbstract Conclusions: Dietary Zn supplementation did not ameliorate MTX-induced small bowel damage, possibly signifying a deficiency in induction of MT by Zn. However, the presence of MT was able to reduce histological damage and neutrophil infiltration caused by MTX in the gut. PMID: 19633421 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2646574 Wed, 29 Jul 2009 08:36:05 +0100 2646574 http://www.medworm.com/index.php?rid=2563473&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571664%26dopt%3DAbstract This study was conducted to explore the possible therapeutic approach of Cox-2 promoter-directed suicide gene therapy with herpes simplex virus thymidine kinase (HSV-tk) in combination with adenoviral technology for advanced colorectal cancer. Firstly, the activity of Cox-2 promoter was assessed by dual luciferase and enhanced green fluorescent protein reporter gene assays in colorectal cancer cell lines and normal human intestinal epithelial cell line. Then, the expression of coxsackievirus and adenovirus receptor (CAR) was detected in colorectal cancer cell lines. The Cox-2 promoter-directed HSV-tk/ganciclovir (GCV) system mediated by adenovirus (Ad-Cp-TK) was developed (Ad-CMVp-TK, Ad-null and no Ad as controls). In vitro cytoxicity, colony formation and apoptosis assays were performed ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2563473 Sun, 05 Jul 2009 09:08:21 +0100 2563473 http://www.medworm.com/index.php?rid=2563461&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571668%26dopt%3DAbstract Conclusions: Celecoxib has demonstrated an outstanding inhibitory effect on bladder cancer chemoprevention, which might be due to its expected anti-inflammatory actions, as well as by anti-proliferatory and antioxidant actions. This data supports a pivotal role of cancer chemoprevention strategies based on COX-2 inhibition. PMID: 19571668 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2563461 Sun, 05 Jul 2009 09:04:06 +0100 2563461 http://www.medworm.com/index.php?rid=2558878&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19360745%26dopt%3DAbstract Authors: Cao C, Wan Y Epidemiological and experimental evidence has supported the notion that solar ultraviolet (UV) radiation is the leading cause of skin cell damage and skin cancer. Non-melanoma skin cancer, one of the malignancies with the most rapidly increasing incidence, is suggested to be directly related to the total exposure to solar UV light. Over the past few years, the mechanisms of cellular responses to UV radiation have received unprecedented attention. Understanding how skin cells respond to UV radiation will undoubtedly help decipher what goes wrong in a variety of clinical skin disorders including skin cancer and will facilitate the development of novel therapeutic strategies. In the past decade, studies have established that UV radiation induces multifarious signal t... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558878 Wed, 01 Jul 2009 16:44:02 +0100 2558878 http://www.medworm.com/index.php?rid=2558810&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19396357%26dopt%3DAbstract CONCLUSION: Our results suggest that lower ED diets do not prevent weight gain but have a weak yet potentially beneficial effect on the prevention of abdominal obesity as measured by waist circumference. PMID: 19396357 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558810 Wed, 01 Jul 2009 16:18:34 +0100 2558810 http://www.medworm.com/index.php?rid=2558808&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19439954%26dopt%3DAbstract Authors: Belhocine K, Galmiche JP The complications of gastroesophageal reflux disease (GERD) include ulcers, strictures, Barrett's esophagus and carcinoma. Although the prevalence of GERD is very high, the development of complications remains quite rare and usually occurs in association with factors generally observed in more severe disease such as hiatal hernia, bile reflux or severely disturbed motility. Recent studies have emphasized the role of obesity and genetic factors as aggravating factors in the development of GERD complications. Barrett's esophagus is the most prevalent complication of GERD and seems to be associated with an increased mortality rate. However, cancer incidence is low and most patients die from other causes, especially cardiovascular disease. PMID: 194399... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558808 Wed, 01 Jul 2009 16:18:34 +0100 2558808 http://www.medworm.com/index.php?rid=2558803&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19439956%26dopt%3DAbstract This article focuses on known and postulated targets for prevention of distal esophageal cancer. PMID: 19439956 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558803 Wed, 01 Jul 2009 16:18:34 +0100 2558803 http://www.medworm.com/index.php?rid=2558799&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19439961%26dopt%3DAbstract Authors: Regula J Screening and surveillance of Barrett's esophagus is a matter of discussion in the current world literature due to uncertainties concerning its cost-effectiveness. Important and valid arguments for and against it are available. Despite the fact that this issue is still to be resolved, screening using standard gastroscopy once in a lifetime and surveillance using repeated endoscopies with multiple blind biopsies are widely practiced by individual gastroenterologists. Further studies that mainly focus on finding better predictors of progression to cancer are needed to be able to prepare clear and useful guidelines. The ultimate aim of screening and surveillance should be decrease in mortality from esophageal adenocarcinoma resulting from Barrett's esophagus. PMID: 1... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558799 Wed, 01 Jul 2009 16:18:34 +0100 2558799 http://www.medworm.com/index.php?rid=2558795&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19476739%26dopt%3DAbstract Authors: Mao JJ, Styles T, Cheville A, Wolf J, Fernandes S, Farrar JT The purpose of this study was to determine the feasibility of an acupuncture clinical trial to prevent radiation therapy (RT)-induced fatigue. We conducted a cross-sectional survey study and a single-arm acupuncture clinical trial among patients undergoing RT. Patients with a Karnofsky score of less than 60, severe anemia, or substantial psychological diagnoses were excluded. Patients received up to 12 treatments of acupuncture over the entire course of their RT. The Lee Fatigue Scale (LFS) was administered at baseline, in the middle of RT, and at the end of RT, along with the Patient Global Impression of Change (PGIC). Among the 48 of 53 (91% response rate) survey participants, 20 (42%) reported that they would part... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558795 Wed, 01 Jul 2009 16:18:34 +0100 2558795 http://www.medworm.com/index.php?rid=2558771&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19562464%26dopt%3DAbstract We describe a new double-stapling technique for esophagojejunostomy and esophagogastrostomy, using a peroral intraluminal approach with a digital stapling system, a flexible shaft remote-control stapler - the Surg-ASSIST and Power Circular Stapler 21 mm (PCS). The overtube of the flexible shaft of the PCS is prepared with a nylon tie and secured to a nasogastric (NG) tube. The flexible shaft is manually advanced down the esophagus with guidance by pulling the NG tube from the abdominal cavity side. The trocar of the flexible shaft is removed from the stump of the abdominal esophagus and connected to the anvil and they are approximated; the stapler device is then fired to form a double-stapled esophagojejunostomy and esophagogastrostomy. Our peroral intraluminal approach does not require a ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558771 Wed, 01 Jul 2009 16:18:27 +0100 2558771 http://www.medworm.com/index.php?rid=2558764&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19562467%26dopt%3DAbstract Authors: Lee J, Lee K, Kim W Duodenal cancer is an uncommon neoplasm and it mostly arises from the periampullary area. However, metachronous or even recurrent cancer at the duodenal stump following Billroth II type distal gastrec tomy for gastric cancer is extremely rare and, to our knowledge, has not yet been reported. A 68-year-old man underwent Billroth II distal gastrectomy with D2 lymph node dissection for an advanced gastric cancer. At that time the tumor stage was T2bN3M0, with 44 of 78 retrieved lymph nodes showing metastasis. He was well without recurrence for 3 years; however, he visited our hospital because of the abrupt onset of dizziness and tarry stool. A polypoid tumor that bled easily when touched was found at the end of the afferent loop of the duodenal stump by gastro... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558764 Wed, 01 Jul 2009 16:18:27 +0100 2558764 http://www.medworm.com/index.php?rid=2558759&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19563130%26dopt%3DAbstract We describe (a) the preparation and use of egg extracts and demembranated sperm chromatin templates; (b) a simple method for preparing silanized glass coverslips suitable for DNA combing and fluorescence detection; (c) two alternative replicative DNA labelling schemes and their respective advantages; and (d) a protocol for combining replicative labelling with detection of specific DNA sequences by fluorescent in situ hybridization (FISH). Although most observations made in Xenopus egg extracts are applicable to other eukaryotes, there are differences in cell-cycle regulation between mammalian somatic cells and embryonic amphibian cells, which led to the development of human cell-free systems that can initiate semi-conservative chromosomal DNA replication under cell-cycle control. We have e... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558759 Wed, 01 Jul 2009 16:18:21 +0100 2558759 http://www.medworm.com/index.php?rid=2558738&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19563700%26dopt%3DAbstract Authors: Kumar P, Shen Q, Pivetti CD, Lee ES, Wu MH, Yuan SY Endothelial hyperpermeability is a significant problem in vascular inflammation associated with trauma, ischaemia-reperfusion injury, sepsis, adult respiratory distress syndrome, diabetes, thrombosis and cancer. An important mechanism underlying this process is increased paracellular leakage of plasma fluid and protein. Inflammatory stimuli such as histamine, thrombin, vascular endothelial growth factor and activated neutrophils can cause dissociation of cell-cell junctions between endothelial cells as well as cytoskeleton contraction, leading to a widened intercellular space that facilitates transendothelial flux. Such structural changes initiate with agonist-receptor binding, followed by activation of intracellular signalli... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558738 Wed, 01 Jul 2009 16:18:11 +0100 2558738 http://www.medworm.com/index.php?rid=2558826&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19395497%26dopt%3DAbstract Authors: Cabrera JE, Cagliero C, Quan S, Squires CL, Jin DJ In Escherichia coli the genome must be compacted approximately 1,000-fold to be contained in a cellular structure termed the nucleoid. It is proposed that the structure of the nucleoid is determined by a balance of multiple compaction forces and one major expansion force. The latter is mediated by transertion, a coupling of transcription, translation, and translocation of nascent membrane proteins and/or exported proteins. In supporting this notion, it has been shown consistently that inhibition of transertion by the translation inhibitor chloramphenicol results in nucleoid condensation due to the compaction forces that remain active in the cell. Our previous study showed that during optimal growth, RNA polymerase is concentra... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558826 Tue, 30 Jun 2009 23:00:00 +0100 2558826 http://www.medworm.com/index.php?rid=2558788&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19559380%26dopt%3DAbstract CONCLUSION: Participation rate at first round was modest. Profile of men who participated compared to men who did not were different. The control group was probably contaminated by PSA testing outside study protocol. Consequences at ERSPC level of this low participation rate on final analysis remain to be determined. PMID: 19559380 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558788 Tue, 30 Jun 2009 23:00:00 +0100 2558788 http://www.medworm.com/index.php?rid=2558785&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19560733%26dopt%3DAbstract Authors: Gu J, Liu Y, Kyritsis AP, Bondy ML Although primary brain tumors (PBTs) are generally considered to be a multifactorial disorder, understanding the genetic basis and etiology of the disease is essential for PBT risk assessment. Understanding of the genetic susceptibility for PBT has come from studies of rare genetic syndromes, linkage analysis, family aggregation, early-onset pediatric cases, and mutagen sensitivity. There are currently no effective markers to assess biological dose of exposures and genetic heterogeneity. The priorities recently recommended by the Brain Tumor Epidemiology Consortium emphasized the need for expanding research in genetics and molecular epidemiology. In this article, we review the literature to identify molecular epidemiologic case-control studie... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558785 Tue, 30 Jun 2009 23:00:00 +0100 2558785 http://www.medworm.com/index.php?rid=2558782&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19561231%26dopt%3DAbstract CONCLUSION: Expression of CK5/6 and HER-1 is frequent in ER-negative breast cancers, in triple negative and in non-triple negative tumours. In a minority of cases, HER-1 overexpression may be caused by HER-1 gene amplification. Further studies are needed to investigate whether such cases might benefit from anti-HER-1 therapy. PMID: 19561231 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558782 Tue, 30 Jun 2009 23:00:00 +0100 2558782 http://www.medworm.com/index.php?rid=2558757&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19563408%26dopt%3DAbstract In conclusion, Fumagillin was found to suppress colorectal cancer growth and metastasis by suppressing angiogenesis. PMID: 19563408 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558757 Tue, 30 Jun 2009 23:00:00 +0100 2558757 http://www.medworm.com/index.php?rid=2558732&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19564288%26dopt%3DAbstract CONCLUSIONS: These data suggested no association between most cancers and very low birth weight, with the exception of the known association of hepatoblastoma and possibly moderately increased risks of other gliomas and retinoblastoma, which may warrant confirmation. PMID: 19564288 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558732 Tue, 30 Jun 2009 23:00:00 +0100 2558732 http://www.medworm.com/index.php?rid=2558712&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19564826%26dopt%3DAbstract Conclusions: This study indicates that the TNF-alpha-308 and TNF-alpha-238 polymorphisms do not influence susceptibility to or severity of lung cancer in a Croatian population.<br /> PMID: 19564826 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558712 Tue, 30 Jun 2009 23:00:00 +0100 2558712 http://www.medworm.com/index.php?rid=2558710&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19565204%26dopt%3DAbstract Authors: Wang M, Wu D, Tan M, Gong W, Xue H, Shen H, Zhang Z The FAS and FAS ligand (FASLG) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. Functional promoter polymorphisms of the FAS and FASLG genes can alter transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS -1377G>A, FAS -670A>G, and FASLG -844T>C polymorphisms in the promoter regions are associated with risk of gastric cancer. In a population-based case-control study of 332 gastric cancer cases and 324 controls, we genotyped these three polymorphisms and evaluated their association with risk of gastric cancer. We found that the FAS and FASL genotypes and the FAS haplotypes had no signifi... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558710 Mon, 29 Jun 2009 23:00:00 +0100 2558710 http://www.medworm.com/index.php?rid=2558708&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19565335%26dopt%3DAbstract Authors: Lerner SP OPINION STATEMENT: Lymph node metastases are the most important prognostic variable in determining outcome following radical cystectomy. An anatomic bilateral node dissection includes at a minimum the external and internal iliac and obturator lymph nodes. An extended node dissection may include the distal aortic and vena caval nodes, bilateral common iliac, and pre-sacral nodes, which receive direct lymphatic drainage from the posterior bladder and trigone. This approach sets up the cystectomy, maximizes sensitivity for detection of nodal metastasis, assures optimum local pelvic cancer control, and accurately identifies those high-risk patients with node metastases who may benefit from adjuvant chemotherapy. Lymph node retrieval is affected by several variables of no... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558708 Mon, 29 Jun 2009 23:00:00 +0100 2558708 http://www.medworm.com/index.php?rid=2558774&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19561644%26dopt%3DAbstract Authors: Herynk MH, Lewis MT, Hopp TA, Medina D, Corona-Rodriguez A, Cui Y, Beyer AR, Fuqua SA We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha. We have developed a transgenic mouse expressing the K303R mutant ERalpha under control of the mouse mammary tumor virus (MMTV) promoter. At 4 months of age, K303R ERalpha transgenic animals demonstrate precocious alveolar budding compared with wild-type ERalpha transgenic mice or nontransgenic littermates. Despite these morphologic differences, K303R ERalpha transgenic mice displayed no differences in levels... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558774 Sun, 28 Jun 2009 23:00:00 +0100 2558774 http://www.medworm.com/index.php?rid=2558772&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19561648%26dopt%3DAbstract Authors: Safdar A, Rodriguez GH, Mihu CN, Mora-Ramos L, Mulanovich V, Chemaly RF, Champlin RE, Khouri I The overall risk of infections is lower in patients undergoing non-myeloablative allogeneic stem cell transplantation (NST) than in conventional stem cell transplant recipients. We sought to evaluate conditions associated with increased risk of infections after NST. In 81 patients, 187 infection episodes were noted; chronic lymphocytic leukemia (138 episodes/100 person-years) and recipients of matched unrelated donor graft (128 episodes/100 person-years) had higher risk of infection. Only half of the cytomegalovirus (CMV) infections occurred 31-100 days after transplantation. Most patients with CMV infection were non-neutropenic (100%), had lymphoma (76%), were younger (<55 years;... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558772 Sun, 28 Jun 2009 23:00:00 +0100 2558772 http://www.medworm.com/index.php?rid=2558752&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19563418%26dopt%3DAbstract Conclusion: The possible roles of CD44v6 in the diagnosis of oral and maxillofacial malignancy deserve further elucidation and evaluation. Serum sCD44v6 may be a valuable marker in monitoring treatment response in patients with OSCC. PMID: 19563418 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558752 Sun, 28 Jun 2009 23:00:00 +0100 2558752 http://www.medworm.com/index.php?rid=2558750&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19563641%26dopt%3DAbstract DISCUSSION: The principal outcome of this project will be the determination of the strength of effect of exercise on the well established musculoskeletal, cardiovascular and insulin metabolism side effects of androgen deprivation in prostate cancer patients. As this project is much longer term than previous investigations in the area of exercise and cancer, we will gain knowledge as to the continuing effects of exercise in this patient population specifically targeting bone density, cardiovascular function, lean and fat mass, physical function and falls risk as primary study endpoints. In terms of advancement of prostate cancer care, we expect dissemination of the knowledge gained from this project to reduce fracture risk, improve physical and functional ability, quality of life and ultima... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558750 Sun, 28 Jun 2009 23:00:00 +0100 2558750 http://www.medworm.com/index.php?rid=2558742&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19563644%26dopt%3DAbstract CONCLUSIONS: Although UPF1 was substantially repressed, thus resulting in the inhibition of the NMD system, we did not find genes inactivated by nonsense mutations. Our results show that the GINI strategy leads to a high number of false positives. PMID: 19563644 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558742 Sun, 28 Jun 2009 23:00:00 +0100 2558742 http://www.medworm.com/index.php?rid=2558739&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19563666%26dopt%3DAbstract CONCLUSIONS: This study suggests that CXCR4 may be a prognostic marker in NSCLC, and provides hypothesis-generating results, which may be important in determining metastatic potential. In future studies, we will prospectively evaluate the prognostic significance of pan-cytokeratin/CXCR4+ cells, and determine the mechanisms involved in the regulation of CXCR4 expression on tumor cells in a larger patient population. PMID: 19563666 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558739 Sun, 28 Jun 2009 23:00:00 +0100 2558739 http://www.medworm.com/index.php?rid=2558720&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19564404%26dopt%3DAbstract Authors: Rocha N, Kuijl C, van der Kant R, Janssen L, Houben D, Janssen H, Zwart W, Neefjes J Late endosomes (LEs) have characteristic intracellular distributions determined by their interactions with various motor proteins. Motor proteins associated to the dynactin subunit p150(Glued) bind to LEs via the Rab7 effector Rab7-interacting lysosomal protein (RILP) in association with the oxysterol-binding protein ORP1L. We found that cholesterol levels in LEs are sensed by ORP1L and are lower in peripheral vesicles. Under low cholesterol conditions, ORP1L conformation induces the formation of endoplasmic reticulum (ER)-LE membrane contact sites. At these sites, the ER protein VAP (VAMP [vesicle-associated membrane protein]-associated ER protein) can interact in trans with the Rab7-RILP com... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558720 Sun, 28 Jun 2009 23:00:00 +0100 2558720 http://www.medworm.com/index.php?rid=2558716&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19564416%26dopt%3DAbstract Authors: Kalinina J, Byron SA, Makarenkova HP, Olsen SK, Eliseenkova AV, Larochelle WJ, Dhanabal M, Blais S, Ornitz DM, Day LA, Neubert TA, Pollock PM, Mohammadi M Uncontrolled fibroblast growth factor (FGF) signaling can lead to human diseases necessitating multiple layers of self-regulatory control mechanisms to keep its activity in check. Herein we demonstrate that FGF9 and FGF20 ligands undergo a reversible homodimerization, occluding their key receptor binding sites. To test the role of dimerization in ligand autoinhibition we introduced structure-based mutations into the dimer interfaces of FGF9 and FGF20. The mutations weakened the ability of the ligands to dimerize, effectively increasing the concentrations of monomeric ligands capable of binding and activating their cognate FG... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558716 Sun, 28 Jun 2009 23:00:00 +0100 2558716 http://www.medworm.com/index.php?rid=2558714&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19564529%26dopt%3DAbstract CONCLUSION: DMAIC framework combined with Lean methodologies is an effective tool to structure the definition, planning, analysis, and implementation of significant process changes. PMID: 19564529 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558714 Sun, 28 Jun 2009 23:00:00 +0100 2558714 http://www.medworm.com/index.php?rid=2558777&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19561362%26dopt%3DAbstract CONCLUSIONS: Australia's new health warnings increased reactions that are prospectively predictive of cessation activity. Warning size increases warning effectiveness and graphic warnings may be superior to text-based warnings. While there is partial wear-out in the initial impact associated with all warnings, stronger warnings tend to sustain their effects for longer. These findings support arguments for governments to exceed minimum FCTC requirements on warnings. PMID: 19561362 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2558777 Sat, 27 Jun 2009 23:00:00 +0100 2558777 http://www.medworm.com/index.php?rid=2530543&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Cancer%2520Control%29%2520AND%2520%25222009%252F04%252F07%252003.43%2522%255BMHDA%255D%253A%25222009%252F06%252F27%252010.35%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Cancer%2520Control%2522%255BTIAB%255D%2520OR%2520%28%2522cancer%2522%255BTIAB%255D%2520AND%2520%2522control%2522%255BTIAB%255D%29%2520OR%2520%2522cancer%2520control%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F04%252F07%252003.43%2522%255BEDAT%255D%29%29 2969 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Cancer Control These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2530543 Sat, 27 Jun 2009 14:35:03 +0100 2530543 http://www.medworm.com/index.php?rid=2198593&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19221517%26dopt%3DAbstract In conclusion, analysis of this large database shows the HPV-16/18 AS04-adjuvanted cervical cancer vaccine to have a favorable safety profile in women of all ages. PMID: 19221517 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2198593 Fri, 20 Feb 2009 13:57:19 +0100 2198593 http://www.medworm.com/index.php?rid=2155491&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19185263%26dopt%3DAbstract CONCLUSIONS: Lemna gibba may be considered as a suitable test organism for further studies on the efficacy of homeopathic potencies. Evidence accumulates, that adjacent potency levels may strongly differ in their biological activity. Potential consequences for therapeutical application might be worth investigating. PMID: 19185263 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2155491 Wed, 04 Feb 2009 05:02:37 +0100 2155491 http://www.medworm.com/index.php?rid=2155490&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19185658%26dopt%3DAbstract Authors: Barter S, Drinkwater K, Remedios D In 2003 the Royal College of Radiologists Clinical Radiology Audit Sub-Committee began an audit process evaluating the standards of provision of magnetic resonance imaging (MRI) services. This was prompted by the publication of the 2002 Audit Commission Report, which had identified that lack of MRI provision was responsible for more than half of the total waiting times for diagnostic imaging investigations. The audit found that the time from request to report did not meet the standard for cancer staging examinations, but nationally, was within the target set for routine orthopaedic examinations. However, national mean waiting times were longer than recommended for both cancer and orthopaedic MRI. Since then, there has been massive investment ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2155490 Wed, 04 Feb 2009 05:02:33 +0100 2155490 http://www.medworm.com/index.php?rid=2149034&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18989878%26dopt%3DAbstract CONCLUSIONS: Applying chronic condition prevalence estimates from a clinical population to the general population of childhood cancer survivors must be undertaken with caution. Survivorship research must maintain a high level of scientific rigor to ensure that results reported in the literature are interpreted within the appropriate context. PMID: 18989878 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2149034 Sun, 01 Feb 2009 04:23:21 +0100 2149034 http://www.medworm.com/index.php?rid=2143853&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18677475%26dopt%3DAbstract CONCLUSIONS: HMW-MAA-specific mAb down-regulated P-Pyk2 expression and enhanced the anti-proliferative effect of cytarabine in vitro, but had no detectable effect on survival or growth of leukemia cells in vivo. Whether the HMW-MAA-specific mAb can be used as carriers of toxins or chemotherapeutic agents against 11q23-acute leukemia remains to be determined. PMID: 18677475 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2143853 Fri, 30 Jan 2009 04:26:13 +0100 2143853 http://www.medworm.com/index.php?rid=2140498&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19172513%26dopt%3DAbstract Conclusions: This result shows that mutation in LCA5 is likely to be a rare genetic cause in Koreans and suggests that further investigation to identify other causative genes is necessary in Koreans. PMID: 19172513 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2140498 Thu, 29 Jan 2009 05:40:33 +0100 2140498 http://www.medworm.com/index.php?rid=2136800&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19167551%26dopt%3DAbstract This article reviews the activities of the Best Practice Council and the projects of teams assigned to study best practice in (1) preventing bloodstream infection (related to central lines), (2) preventing patient falls, (3) assessing and preventing pressure ulcers, and (4) ensuring good hand-off communication. PMID: 19167551 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2136800 Wed, 28 Jan 2009 04:31:34 +0100 2136800 http://www.medworm.com/index.php?rid=2130646&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19048628%26dopt%3DAbstract Authors: Shen J, Ambrosone CB, Zhao H MicroRNA (miRNA) plays an important role in tumorigenesis, but whether miRNA is a cancer predisposition factor or not is still unknown. Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. To test this hypothesis, we screened genetic variants in 17 selected miRNA genes, which are predicted to regulate key breast cancer genes, in 42 patients with familial breast cancer. Seven novel genetic variants were observed in 7 primary or precursor miRNA genes. Among them, 1 rare variant in the precursor of miR-30c-1 and 1 rare variant in the primary precursor of miR-17 were only observed in nonca... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2130646 Sun, 25 Jan 2009 04:16:28 +0100 2130646 http://www.medworm.com/index.php?rid=2130645&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19048630%26dopt%3DAbstract Authors: Su X, Guo S, Zhou C, Wang D, Ma W, Zhang S Allogeneic mixed leukocytes reaction has been reported to activate vast numbers of T lymphocytes and produce large amounts of type 1 cytokines that are linked to an initiation of antitumor immunity. Using poor immunogeneic B16-F10 and Lewis lung carcinoma (LLC) tumor model, we evaluated the effects of inactivated allogeneic leukocytes infusion (ALI) on the generation of antitumor immune response, as well as its effect on the primary and metastatic tumor. Allogeneic response promoted the generation of both specific and nonspecific antitumor immunity in an in vitro mixed lymphocytes-tumor cell culture system. Introveinous infusion of mitotically inactivated allogeneic leukocytes resulted in increased type-1 cytokines (including IL-2 and... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2130645 Sun, 25 Jan 2009 04:16:25 +0100 2130645 http://www.medworm.com/index.php?rid=2130644&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058175%26dopt%3DAbstract Authors: Villeneuve S, Orsi L, Monnereau A, Berthou C, Fenaux P, Marit G, Soubeyran P, Huguet F, Milpied N, Leporrier M, Hemon D, Troussard X, Clavel J Lymphoid neoplasms (LNs), including non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), lymphoproliferative syndrome (LPS) and multiple myeloma (MM), are among the most frequent cancers ( approximately 17,000 new cases per year in France), after those related to smoking. LNs were investigated using the data from the ENGELA study. ENGELA is a multicenter hospital-based case-control study that was carried out in France over the period September 2000-December 2004. In all, 822 cases (397 NHL, 149 LH, 168 SLP and 108 MM) and 752 controls were included and described 5,481 and 5,188 first-degree relatives, respectively. A positive associat... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2130644 Sun, 25 Jan 2009 04:16:22 +0100 2130644 http://www.medworm.com/index.php?rid=2130643&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058182%26dopt%3DAbstract Authors: Mould AW, Duncan R, Serewko-Auret M, Loffler KA, Biondi C, Gartside M, Kay GF, Hayward NK Heterozygous disruption of the Men1 gene predisposes mice to the development of multiple endocrine tumors, accurately mimicking the human MEN1 cancer predisposition syndrome. Additionally, Men1(+/-) mice frequently develop sex cord adenomas. The mechanism underlying the susceptibility of these mice to sex cord tumor development has not been fully determined, but data suggest it may involve transcriptional regulation of key growth promoting/repressing genes. To identify potential menin-regulated genes that may be important for tumor suppression in sex cord cells, we compared the global gene expression profiles of testis and ovary adenomas with other endocrine tumors of the pancreas and pit... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2130643 Sun, 25 Jan 2009 04:16:18 +0100 2130643 http://www.medworm.com/index.php?rid=2130642&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058216%26dopt%3DAbstract In conclusion, hypertension has prognostic significance in relation to survival disparity between African-American and white breast cancer patients. If our findings are replicated in contemporary cohorts, it may be necessary to include hypertension in the Charlson Comorbidity Index and other comorbidity measures. PMID: 19058216 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2130642 Sun, 25 Jan 2009 04:16:14 +0100 2130642 http://www.medworm.com/index.php?rid=2130641&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058220%26dopt%3DAbstract Authors: Dafou D, Ramus SJ, Choi K, Grun B, Trott DA, Newbold RF, Jacobs IJ, Jones C, Gayther SA Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome transfer (MMCT) to establish the functional effects of transferring normal copies of these chromosomes into 2 epithelial OC cell lines (TOV112D and TOV21G). The in vitro neoplastic phenotype (measured as anchorage dependent and independent growth and invasion) was compared between recipient OC cell lines and multiple MMCT hybrids. Chromosomes 6 and 18 showed strong evidence of functional, neoplastic suppression for multiple hybrids in both cell lines. We also found evidence in 1... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2130641 Sun, 25 Jan 2009 04:16:10 +0100 2130641 http://www.medworm.com/index.php?rid=2130640&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19065667%26dopt%3DAbstract Authors: Ye L, Gho WM, Chan FL, Chen S, Leung LK Licorice is the sweet-tasting rhizomes of a bean plant and is quite commonly used in Western countries for culinary purposes, while it is a medicinal herb in China. Many flavonoids have been isolated from licorice, and their pharmacological properties may be applicable in preventive medicine. Overexposure to estrogen has been implicated in the etiology of breast cancer, and cytochrome P450 (CYP) 19 enzyme, or aromatase, catalyzes the rate-limiting reaction. Phytocompounds that are able to inhibit this enzyme may potentially suppress breast cancer development. In the present study the licorice flavonoid isoliquiritigenin (ILN) was shown to be an aromatase inhibitor in recombinant protein and MCF-7 cells stably transfected with CYP19 (MCF-... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2130640 Sun, 25 Jan 2009 04:16:06 +0100 2130640 http://www.medworm.com/index.php?rid=2127811&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19159399%26dopt%3DAbstract Authors: Heck JE, Ritz B, Hung RJ, Hashibe M, Boffetta P Neuroblastoma is the most common tumour in children less than 1 year of age. The goal of this review was to summarise the existing epidemiological research on risk factors for neuroblastoma. A comprehensive search of the literature was undertaken using PubMed for epidemiological studies on neuroblastoma risk factors. We ascertained 47 articles which examined the risk factors. Ten studies employed population-based case-control designs; six were hospital-based case-control studies; two were cohort studies; and five employed ecological designs. Studies ranged in size from 42 to 538 cases. Three studies showed evidence of an increased risk of disease with use of alcohol during pregnancy (OR range 1.1, 12.0). Protective effects were s... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2127811 Sat, 24 Jan 2009 05:21:25 +0100 2127811 http://www.medworm.com/index.php?rid=2106970&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19030177%26dopt%3DAbstract Authors: Kumagai J, Urano T, Ogushi T, Takahashi S, Horie-Inoue K, Fujimura T, Azuma K, Muramatsu M, Ouchi Y, Kitamura T, Inoue S Upregulation of EBAG9 expression has been observed in several malignant tumors such as advanced breast and prostate cancers, indicating that EBAG9 may contribute to tumor proliferation. In the present study, we assess the role of EBAG9 in bladder cancer. We generated human bladder cancer EJ cells stably expressing FLAG-tagged EBAG9 (EJ-EBAG9) or empty vector (EJ-vector), and investigated whether EBAG9 overexpression modulates cell growth and migration in vitro as well as the in vivo tumor formation of EJ transfectants in xenograft models of BALB/c nude mice. EBAG9 overexpression promoted EJ cell migration, while the effect of EBAG9 to cultured cell growth wa... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106970 Fri, 16 Jan 2009 05:06:44 +0100 2106970 http://www.medworm.com/index.php?rid=2106969&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19035442%26dopt%3DAbstract Authors: Chia VM, Li Y, Goldin LR, Graubard BI, Greene MH, Korde L, Rubertone MV, Erickson RL, McGlynn KA Risk factors for testicular germ cell tumors (TGCT) have not been well identified; however, data suggest that risks of cancer in family members of men with TGCT is elevated. Using family history data from 738 cases and 904 controls enrolled in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) Study from 2002 to 2005, the risk of cancer in first- and second-degree family members of these men was examined. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for reference age of case or control, race/ethnicity of case or control, sex of family member and lineage (maternal vs. pate... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106969 Fri, 16 Jan 2009 05:06:40 +0100 2106969 http://www.medworm.com/index.php?rid=2106968&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19035445%26dopt%3DAbstract We examined the relationship between prediagnostic serum 25-hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort (1985-2002) of 29,133 Finnish male smokers (ages 50-69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth-year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95% confidence interval (CI), 0.50, 1.14) and 0.82 (95% CI, 0.53, 1.26). The 25(OH)D-NHL association, ho... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106968 Fri, 16 Jan 2009 05:06:36 +0100 2106968 http://www.medworm.com/index.php?rid=2106967&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19035448%26dopt%3DAbstract In conclusion, our model results support the implementation of HPV16/18 vaccination in young women in addition to cervical cancer screening. PMID: 19035448 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106967 Fri, 16 Jan 2009 05:06:31 +0100 2106967 http://www.medworm.com/index.php?rid=2106966&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19035449%26dopt%3DAbstract In conclusion, exposure of professional military personnel to anti-aircraft radars that existed in Western Europe from the 1960s until the 1990s may have resulted in an increase in the incidence of hemolymphatic cancers. It remains to be established whether this increase is due to microwaves generated by radars or ionizing radiation produced by electronic devices producing the microwaves. PMID: 19035449 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106966 Fri, 16 Jan 2009 05:06:26 +0100 2106966 http://www.medworm.com/index.php?rid=2106965&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19035450%26dopt%3DAbstract Authors: Olsen CM, Zens MS, Stukel TA, Sacerdote C, Chang YM, Armstrong BK, Bataille V, Berwick M, Elwood JM, Holly EA, Kirkpatrick C, Mack T, Bishop JN, Østerlind A, Swerdlow AJ, Zanetti R, Green AC, Karagas MR, Whiteman DC A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inherent propensity to develop nevi will tend to develop melanomas most often on body sites with large melanocyte populations, such as on the back. We conducted a collaborative analysis to test this hypothesis using the original data from 10 case-contro... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106965 Fri, 16 Jan 2009 05:06:22 +0100 2106965 http://www.medworm.com/index.php?rid=2106964&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19035453%26dopt%3DAbstract Authors: Thiébaut AC, Chajès V, Gerber M, Boutron-Ruault MC, Joulin V, Lenoir G, Berrino F, Riboli E, Bénichou J, Clavel-Chapelon F Experimental studies suggest detrimental effects of omega-6 polyunsaturated fatty acids (PUFA), and beneficial effects of omega-3 PUFAs on mammary carcinogenesis, possibly in interaction with antioxidants. However, PUFA food sources are diverse in human diets and few epidemiologic studies have examined whether associations between dietary PUFAs and breast cancer risk vary according to food sources or antioxidant intakes. The relationship between individual PUFA intakes estimated from diet history questionnaires and breast cancer risk was examined among 56,007 French women. During 8 years of follow-up, 1,650 women developed invasive breast ca... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106964 Fri, 16 Jan 2009 05:06:16 +0100 2106964 http://www.medworm.com/index.php?rid=2106963&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19035456%26dopt%3DAbstract Authors: Moore SC, Leitzmann MF, Albanes D, Weinstein SJ, Snyder K, Virtamo J, Ahn J, Mayne ST, Yu H, Peters U, Gunter MJ Adiposity and adipocyte-derived cytokines have been implicated in prostate carcinogenesis. However, the relationship of adipokine gene variants with prostate cancer risk has not been thoroughly investigated. We therefore examined common variants of the IL6, LEP, LEPR, TNF and ADIPOQ genes in relation to prostate cancer in a case-control study nested within a large cohort of Finnish men. The study sample consisted of 1,053 cases of prostate cancer, diagnosed over an average 11 years of follow up, and 1,053 controls matched to the cases on age, intervention group and date of baseline blood draw. Logistic regression was used to model the relative odds of prostate cance... Cancer Control journals http://www.medworm.com/rss/comments.php?id=2106963 Fri, 16 Jan 2009 05:05:59 +0100 2106963 http://www.medworm.com/index.php?rid=1988630&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19029818%26dopt%3DAbstract Authors: Lee G, Chu RA, Ting HH RP215 monoclonal antibody was originally generated against OC-3-VGH ovarian cancer cells. It was shown to recognize specifically a carbohydrate-associated epitope(s) of cancer cell-expressed immunoglobulin heavy chains designated as CA215. Previous studies suggest that CA215 is expressed by all human cancer cell lines and tissues in both membrane bound and secreted forms. It may be an ideal target for therapeutic treatments of human cancers with humanized RP215-related antibodies. Based on the results of large scale immunohistochemical studies (50-100 cases each), the following types of cancers revealed high percentage(s) of positive staining with RP215: esophagus (76%), stomach (50%), colon (44%), ovary (64%), breast (32%), lung (31%), cervix (84%) and ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1988630 Thu, 27 Nov 2008 05:51:45 +0100 1988630 http://www.medworm.com/index.php?rid=1967373&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19011290%26dopt%3DAbstract Authors: Stanworth RD, Jones TH Testosterone levels are reduced in obesity, the metabolic syndrome and type 2 diabetes. Low testosterone levels are now being recognised as an independent risk factors for these conditions. Findings from men undergoing androgen suppression as treatment for prostate cancer confirm that the hypogonadal state increases body fat mass and serum insulin and there is a high rate of developing new diabetes in this population. Clinical trial data are consistent in showing reductions in body fat mass during testosterone replacement therapy. There are also trials showing improvements in insulin resistance and glycaemic control with testosterone. Most of the trials in this area to date have been of small size and the promising results require confirmation in larger ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1967373 Wed, 19 Nov 2008 04:52:46 +0100 1967373 http://www.medworm.com/index.php?rid=1942323&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18987534%26dopt%3DAbstract CONCLUSION: This study showed that chuanxiongzine-puerarin played an important protective role against cerebral ischemic reperfusion damage in a rat model. PMID: 18987534 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1942323 Sat, 08 Nov 2008 08:43:58 +0100 1942323 http://www.medworm.com/index.php?rid=1942322&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18987809%26dopt%3DAbstract Authors: Yan PS, Potter D, Deatherage DE, Huang TH, Lin S Differential methylation hybridization (DMH) is a high-throughput DNA methylation screening tool that utilizes methylation-sensitive restriction enzymes to profile methylated fragments by hybridizing them to a CpG island microarray. This array contains probes spanning all the 27,800 islands annotated in the UCSC Genome Browser. Herein we describe a revised DMH protocol with clearly identified quality control points. In this manner, samples that are unlikely to provide good readouts for differential methylation profiles between the test and the control samples will be identified and repeated with appropriate modifications. In addition to the step-by-step laboratory DMH protocol, we also provide a detailed description regarding DM... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1942322 Sat, 08 Nov 2008 08:43:55 +0100 1942322 http://www.medworm.com/index.php?rid=1942321&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18987810%26dopt%3DAbstract Authors: Jordà M, Rodríguez J, Frigola J, Peinado MA DNA methylation is an epigenetic modification that plays a crucial role in the control of gene expression and chromosome structure in plants and mammalian cells. Multiple types of DNA fingerprinting techniques have been developed and applied to investigate DNA methylation profiles in different experimental settings. One of these techniques, the amplification of intermethylated sites (AIMS) is a simple approach appropriate for genome-wide estimates of DNA methylation and the discovery of specific methylated sequences. AIMS is based on the differential enzymatic digestion of genomic DNA with methylation-sensitive and methylation-insensitive isoschizomers followed by restrained PCR amplification of methylated sequences. This m... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1942321 Sat, 08 Nov 2008 08:43:52 +0100 1942321 http://www.medworm.com/index.php?rid=1942320&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18987824%26dopt%3DAbstract We describe the experimental steps of MethyLight analysis in detail. Furthermore, we present here principles and design examples for three types of quality-control reactions. QC-1 reactions are methylation-independent reactions to monitor sample quantity and integrity. QC-2 reactions are bisulfite-independent reactions to monitor recovery efficiencies of the bisulfite-conversion methodology used. QC-3 reactions are bisulfite-independent primed reactions with variable bisulfite-dependent probing to monitor completeness of the sodium bisulfite treatment. We show that these control reactions perform as expected in a time-course experiment interrupting sodium bisulfite conversion at various timepoints. PMID: 18987824 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1942320 Sat, 08 Nov 2008 08:43:48 +0100 1942320 http://www.medworm.com/index.php?rid=1885405&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18651561%26dopt%3DAbstract Authors: Zou GM It has been suggested that cancer stem cells population within the solid tumor with indefinite proliferation potential drives the growth and metastasis of cancer. In literature, these malignant stem cells also named Cancer initiating cells. Cancer stem cells exhibit low rate of division and proliferation in their niche that help them to avoid chemotherapy and radiation. Epithelial cancers are believed to originate from transformation of tissue stem cells. Bone marrow-derived cells, which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy in the gastrointestinal tract. Pancreatic cancer is one of most common cause of cancer-related death. Pancreatic cancer stem cells have been characterized recently ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1885405 Sat, 18 Oct 2008 08:14:46 +0100 1885405 http://www.medworm.com/index.php?rid=1885404&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18923370%26dopt%3DAbstract Authors: Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G Anaplastic thyroid cancer (ATC) is a rare aggressive tumor arising from the follicular cells of the thyroid gland (as does well differentiated thyroid cancer, WDTC), but ATC cells do not retain any of the biological features of the original follicular cells, such as uptake of iodine and synthesis of thyroglobulin. Prognosis is almost invariably fatal. In this article the Authors review the pathology, epidemiology, clinical presentation, diagnosis and treatment options of ATC. ATC incidence typically peaks at the 6-7th decade of life (mean age at diagnosis 55-65 years), women representing 55-77% of all patients. ATC represents 2-5% of all thyroid tumors, with a decreasing trend with respect to the incidence of WDT... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1885404 Sat, 18 Oct 2008 08:14:38 +0100 1885404 http://www.medworm.com/index.php?rid=1870118&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18651572%26dopt%3DAbstract Authors: Lähteenmäki PM, Sankila R, Pukkala E, Kyyrönen P, Harila-Saari A Cancer treatment may affect school performance. School report grades after childhood lymphomas and Wilms tumor have not been previously reported. All Finnish patients with Wilms tumor (N = 74), Hodgkin lymphoma (HL) (N = 99) and non-Hodgkin lymphoma (NHL) (N = 94) who were born in 1974-1986 and had achieved the age of 16 years were identified from the Finnish cancer registry. Population controls (N = 1329) were matched for age, gender and residence. Their 9th grade school reports were obtained from Statistics Finland. The overall average and grades for mother tongue, first foreign language, mathematics and physical education were compared between the patients and their controls. Almost all the pati... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1870118 Mon, 13 Oct 2008 08:08:00 +0100 1870118 http://www.medworm.com/index.php?rid=1870117&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18720403%26dopt%3DAbstract Authors: Smith JS, Kumlin U, Nyberg F, Fortes C, Zaridze D, Ahrens W, Bruske-Hohlfeld I, Constantinescu V, Ting J, Benhamou S, Simonato L, Boman J, Gaborieau V, Boffetta P PMID: 18720403 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1870117 Mon, 13 Oct 2008 08:07:56 +0100 1870117 http://www.medworm.com/index.php?rid=1870116&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18720404%26dopt%3DAbstract Authors: Hautala LC, Koistinen R, Seppälä M, Bützow R, Stenman UH, Laakkonen P, Koistinen H Malignant growth is characterized by loss of cell differentiation, uncontrolled proliferation and resistance to apoptosis. Many tumor suppressor genes that protect cells against malignant transformation regulate cell differentiation. Here, we show for the first time that glycodelin, a differentiation-related protein, reduces breast cancer tumor growth in vivo. We found that glycodelin cDNA-transfected MCF-7 breast cancer cells showed a differentiated phenotype and produced smaller tumors in mouse mammary fat pads compared with control-transfected cells. Glycodelin-induced differentiation was associated with reduced expression of oncogenes and increased expression of tumor suppress... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1870116 Mon, 13 Oct 2008 08:07:53 +0100 1870116 http://www.medworm.com/index.php?rid=1870115&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18729188%26dopt%3DAbstract Authors: Rollison DE, Pawlita M, Giuliano AR, Iannacone MR, Sondak VK, Messina JL, Cruse CW, Fenske NA, Glass LF, Kienstra M, Michael KM, Waterboer T, Gheit T, Tommasino M Cutaneous human papillomavirus (HPV) may be associated with the development of nonmelanoma skin cancer (NMSC), as suggested by reports of HPV DNA in NMSC tumors. HPV has also been investigated as an NMSC risk factor in epidemiologic studies, although findings vary across studies that used different biomarkers of HPV infection in normal tissues. To identify appropriate biomarkers for use in future epidemiologic studies, we conducted a sampling validation study. NMSC tumor tissue was obtained from 20 patients with pathology-confirmed basal or squamous cell carcinoma of the skin, in addition to several normal tissues, i... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1870115 Mon, 13 Oct 2008 08:07:50 +0100 1870115 http://www.medworm.com/index.php?rid=1870114&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18729191%26dopt%3DAbstract Authors: Lucenteforte E, Garavello W, Bosetti C, Talamini R, Zambon P, Franceschi S, Negri E, La Vecchia C A varied diet may have a favorable role against digestive tract cancers. We analyzed the relationship between diet diversity (i.e. measured by the number of different foods consumed at least once per week) and the risk of esophageal cancer. We considered data from a case-control study conducted between 1992 and 1997 in northern Italy on 304 squamous cell esophageal cancer cases below age 78 years and 743 controls admitted to hospital for acute, nonneoplastic conditions, unrelated to tobacco or alcohol consumption. There was a significant inverse association for total diet diversity: the multivariate odds ratio (OR), adjusted for age, sex, area of residence, education, tobacco smok... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1870114 Mon, 13 Oct 2008 08:07:46 +0100 1870114 http://www.medworm.com/index.php?rid=1864815&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18841050%26dopt%3DAbstract Authors: Soffietti R, Rudà R, Trevisan E PURPOSE OF REVIEW: To review the state-of-the-art and new developments in the management of patients with brain metastases. RECENT FINDINGS: Treatment decisions are based on prognostic factors to maximize neurologic function and survival, while avoiding unnecessary therapies. Whole-brain radiotherapy (WBRT) is the treatment of choice for patients with unfavorable prognostic factors. Stereotactic radiosurgery (SRS) or surgery is indicated for patients with favorable prognostic factors and limited brain disease. In single brain metastasis, the addition of either stereotactic radiosurgery or surgery to WBRT improves survival. The omission of WBRT after surgery or radiosurgery results in a worse local and distant control, though it does not aff... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1864815 Fri, 10 Oct 2008 08:41:11 +0100 1864815 http://www.medworm.com/index.php?rid=1861934&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18649369%26dopt%3DAbstract CONCLUSIONS: This study provides evidence that the addition of an analgesic (fentanyl) and an anti-emetic (ondansetron) to the combination of a sedative (midazolam) and an anesthetic (propofol) is of measurable benefit in children who undergo procedures that are painful and risk the consequence of nausea and vomiting. PMID: 18649369 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1861934 Thu, 09 Oct 2008 09:29:31 +0100 1861934 http://www.medworm.com/index.php?rid=1858761&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18836371%26dopt%3DAbstract CONCLUSION: Patients with chronic renal failure exhibited significant salivary gland, oral, nasal, and gastric activity 1 week after radioiodine administration. The linear pattern of oral activity unresponsive to rinsing and persistence of gastric activity for 1 week might suggest adsorption of radioiodine to mucosal cells. Salivary gland dysfunction and the risk of second primary malignancy in iodine-concentrating organs appear as important indications for radioiodine dose reduction in this patient group. PMID: 18836371 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1858761 Wed, 08 Oct 2008 09:23:00 +0100 1858761 http://www.medworm.com/index.php?rid=1852249&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18468681%26dopt%3DAbstract Authors: van den Ancker W, Westers TM, Ossenkoppele GJ, van de Loosdrecht AA PMID: 18468681 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1852249 Sun, 05 Oct 2008 08:18:17 +0100 1852249 http://www.medworm.com/index.php?rid=1778193&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18774901%26dopt%3DAbstract Authors: Mieyal JJ, Gallogly MM, Qanungo S, Sabens EA, Shelton MD Sulfhydryl chemistry plays a vital role in normal biology and in defense of cells against oxidants, free radicals, and electrophiles. Modification of critical cysteine residues is an important mechanism of signal transduction, and perturbation of thiol-disulfide homeostasis is an important consequence of many diseases. A prevalent form of cysteine modification is reversible formation of protein mixed disulfides (protein-SSG) with glutathione (GSH). The abundance of GSH in cells and the ready conversion of sulfenic acids and S-nitroso derivatives to S-glutathione mixed disulfides suggests that reversible S-glutathionylation may be a common feature of redox signal transduction and regulation of the activities of redox sens... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1778193 Wed, 10 Sep 2008 08:10:50 +0100 1778193 http://www.medworm.com/index.php?rid=1753564&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18758234%26dopt%3DAbstract Authors: Roca H, Varsos ZS, Mizutani K, Pienta KJ Recent data strongly support the idea that the orchestrated interaction between cancer and other cells in the tumor microenvironment is a vital component in the neoplastic process. Thus, tumor cells take advantage of the signaling molecules of the immune system to proliferate, survive, and invade other tissues. CCL2 (Chemokine (C-C motif) ligand 2, Monocyte chemoattractant protein-1 (MCP-1) has been demonstrated to play a significant role in prostate cancer neoplasia and invasion, and is highly expressed in the tumor microenvironment. We recently reported that CCL2 elicits a strong survival advantage in prostate cancer PC3 cells through PI3K/Akt-dependent regulation of autophagy via the mammalian target of rapamycin (mTOR) pathway and i... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1753564 Wed, 03 Sep 2008 08:06:28 +0100 1753564 http://www.medworm.com/index.php?rid=1722575&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18713968%26dopt%3DAbstract Authors: Fabre S, Carrette F, Chen J, Lang V, Semichon M, Denoyelle C, Lazar V, Cagnard N, Dubart-Kupperschmitt A, Mangeney M, Fruman DA, Bismuth G In T cells, the PI3K pathway promotes proliferation and survival induced by Ag or growth factors, in part by inactivating the FOXO transcription factor 1. We now report that FOXO1 controls the expression of L-selectin, an essential homing molecule, in human T lymphocytes. This control is already operational in unprimed T cells and involves a transcriptional regulation process that requires the FOXO1 DNA-binding domain. Using transcriptional profiling, we demonstrate that FOXO1 also increases transcripts of EDG1 and EDG6, two sphingosine-1-phosphate receptors that regulate lymphocyte trafficking. Additionally, FOXO1 binds the promoter of the... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1722575 Fri, 22 Aug 2008 08:13:07 +0100 1722575 http://www.medworm.com/index.php?rid=1722574&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18714045%26dopt%3DAbstract Authors: Zhang M, Berndt BE, Chen JJ, Kao JY Dendritic cell (DC)-based antitumor immunotherapy is a promising cancer therapy. We have previously shown that tumor-derived TGF-beta limits the efficacy of the DC/tumor fusion vaccine in mice. In the current study we investigated the effect of neutralizing tumor-derived TGF-beta on the efficacy of the DC/tumor fusion vaccine. An adenovirus encoding human TGF-beta receptor type II fused to the Fc region of human IgM (Adv-TGF-beta-R) or a control adenovirus encoding LacZ (Adv-LacZ) was used to express a soluble form of the neutralizing TGF-beta receptor (TGF-beta-R). Murine breast carcinoma cells, 4T1, but not bone marrow-derived DCs, were successfully transfected with Adv-TGF-beta-R (4T1+Adv-TGF-beta-R) using a multiplicity of infection of 3... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1722574 Fri, 22 Aug 2008 08:13:00 +0100 1722574 http://www.medworm.com/index.php?rid=1722573&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18714048%26dopt%3DAbstract Authors: Laronne-Bar-On A, Zipori D, Haran-Ghera N CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) play a central role in cancer tolerance. However, mechanisms leading to their accumulation in cancer remain unknown. Although the thymus is the main site of Treg development, thymic contribution to Treg expansion in cancer has not been directly examined. Herein, we used two murine models of multiple myeloma (MM), 5T2 MM and 5T33 MM, to examine Treg accumulation in peripheral lymphoid organs, including spleen, lymph nodes, bone marrow, and blood, and to explore thymic Treg development during malignancy. We found that peripheral ratios of suppressive-functional Tregs increased in both models of MM-inflicted mice. We found that thymic ratios of Treg development in MM increased, in strong as... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1722573 Fri, 22 Aug 2008 08:12:57 +0100 1722573 http://www.medworm.com/index.php?rid=1722572&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18714181%26dopt%3DAbstract Authors: Sánchez L, Lana A, Hidalgo A, Rodríguez JM, Del Valle Mdel O, Cueto A, Folgueras MV, Belyakova E, Comendador MA, López ML Breast cancer (BC) survivors have an increased risk of developing second primary cancer (SPC). The aim of this study was to detect and compare SPC predictors linked to the host, the first BC and its treatment. Two hundred and seventeen patients with a nonbreast SPC and 465 matched controls, nested in the cohort of BC patients diagnosed in a Spanish region between 1975 and 2003, were involved in a case-control study. The Tumour Registry database provided information about the host, BC and its treatment factors. Their contribution to the risk of developing SPC was measured by means of a conditional logistic regression. After controlling for dif... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1722572 Fri, 22 Aug 2008 08:12:54 +0100 1722572 http://www.medworm.com/index.php?rid=1722571&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18714185%26dopt%3DAbstract Authors: Almog R, Ezra G, Lavi I, Rennert G, Hagoel L The acceptability of colorectal cancer (CRC) screening tests to the population influences adherence. Population preferences between fecal occult blood test (FOBT) and colonoscopy for CRC screening were examined by previous test experience. The study population was a random sample of 413 members of Israel's largest Health Maintenance Organization (HMO) aged 48-68 years. In a telephone interview, an explanation was provided regarding FOBT and colonoscopy. Participants were asked which they preferred and their degree (1-6) of agreement with each of eight test characteristics. Overall Attitude Scores toward FOBT and colonoscopy were compared. Predictors of colonoscopy preference and of refusal to undergo screening were examined using a ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1722571 Fri, 22 Aug 2008 08:12:51 +0100 1722571 http://www.medworm.com/index.php?rid=1722570&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18714186%26dopt%3DAbstract Authors: Herszényi L, István G, Cardin R, De Paoli M, Plebani M, Tulassay Z, Farinati F Cathepsin B (CATB) and urokinase-type plasminogen activator (UPA) play an important part in cancer invasion and metastasis. The behavior of CATB and UPA has not been evaluated in the same experimental setting in different gastrointestinal tumors and in precancerous lesions. Serum CATB and plasma UPA levels were determined by enzyme-linked immunoadsorbent assay and their sensitivity, specificity, and diagnostic accuracy have been calculated in patients with colorectal (n=72), gastric (n=30), hepatocellular (n=28), and pancreatic cancer (n=15) as well as in gastric epithelial dysplasia (n=25), colorectal adenomas (n=30), and tumor-free control patients (n=44). Serum CATB and plasma UPA antig... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1722570 Fri, 22 Aug 2008 08:12:43 +0100 1722570 http://www.medworm.com/index.php?rid=1722569&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18714191%26dopt%3DAbstract This study gives further support and quantification of the positive association between IAP, history of selected nonmalignant lung diseases, and lung cancer risk for both the sexes. PMID: 18714191 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1722569 Fri, 22 Aug 2008 08:12:34 +0100 1722569 http://www.medworm.com/index.php?rid=1704050&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18695900%26dopt%3DAbstract In conclusion, a beneficial effect of bevacizumab against postoperative lung metastases may be expected even after the establishment of neovascularization in metastatic foci in nude rat. The results from the present subcutaneously implanted tumor model suggested that a higher efficacy may be expected when bevacizumab is combined with the cytotoxic agent CPT-11, compared to bevacizumab alone, against tumors with a variety of VEGF production levels in clinical situations. PMID: 18695900 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1704050 Thu, 14 Aug 2008 10:48:49 +0100 1704050 http://www.medworm.com/index.php?rid=1704049&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18695902%26dopt%3DAbstract Authors: Navarrete Montalvo D, González M N, Montalvo V MT, Jiménez A A, Echiburú-Chau C, Calaf GM Breast cancer is the leading cause of death affecting women worldwide, according to mortality estimation and incidence. In Chile, breast cancer ranks third among cancer mortality rates. Two-hundred and eighty-three breast cancer patients registered at the Gustavo Fricke Hospital of Viña del Mar, Chile, were studied to assess the influence of several factors on the recurrence and survival of breast cancer patients. Patients selected had 5-year post-surgery recurrences of breast cancer and had an average of 58.5 years of age. The variables considered in these patients were the quadrants involved, stage of the tumor, type of recurrence, type of exams, type of surgery, the... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1704049 Thu, 14 Aug 2008 10:48:43 +0100 1704049 http://www.medworm.com/index.php?rid=1704048&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18695904%26dopt%3DAbstract In this study, we used image analysis and green fluorescent protein (GFP) to objectively measure tumor size in response to chemotherapy. KU-7 human bladder cancer cells transfected with GFP were intravesically inoculated into 8-week-old female nude mice. Fourteen days after tumor cell inoculation, the mice were assigned into a control (PBS) group or a doxorubicin (conc. 1.0 mg/ml) treatment group and received a single instillation of treatment. Fourteen days after treatment, the bladders were surgically exposed and fluorescent images were captured and later analyzed using image analysis. Bladders were processed for histological examination. Tumor incidence determined by GFP expression and histology was 100 and 80%, respectively, in the doxorubicin treatment group. A 9-fold (histology) vs. ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1704048 Thu, 14 Aug 2008 10:48:40 +0100 1704048 http://www.medworm.com/index.php?rid=1704047&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18695912%26dopt%3DAbstract This study provides evidence that E2F-1 and COX-2 are overexpressed in oral cancer, and further supports suppression of COX-2 in control of oral cancer. PMID: 18695912 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1704047 Thu, 14 Aug 2008 10:48:38 +0100 1704047 http://www.medworm.com/index.php?rid=1704046&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18695918%26dopt%3DAbstract In this study, we used a COX-2 transfected clone KB/COX-2 and a neomycin-transfected clone KB/neo as the control. When we examined the susceptibility to anticancer agents, there was no difference between these two clones in vincristine, bleomycin and 5-fluorouracil, although KB/COX-2 showed a 2.5-fold resistance to cisplatin (CDDP) as compared with KB/neo. The IC50 for CDDP was 4.3 microM in KB/COX-2 and 1.7 microM in KB/neo. Treatment with small interfering RNA (siRNA) mediated the inhibition of COX-2 significantly increasing the level of susceptibility to CDDP in COX-2 siRNA as compared to that of the control siRNA. The expression of MRP1 and MRP2 was stronger in KB/COX-2 than in KB/neo by Western blot analysis. In addition, apoptosis induction by CDDP was at a lower level in KB/COX-2 (3... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1704046 Thu, 14 Aug 2008 10:48:35 +0100 1704046 http://www.medworm.com/index.php?rid=1704045&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18695924%26dopt%3DAbstract In conclusion, we suggest that mitochondrial 4977-bp deletion is not specific to EC tissues. The accumulation of mtDNA4977 may be associated with aging processes, particularly in peri-menopausal women affected by EC. PMID: 18695924 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1704045 Thu, 14 Aug 2008 10:48:31 +0100 1704045 http://www.medworm.com/index.php?rid=1699521&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18690092%26dopt%3DAbstract The objective of this study was to evaluate the cytotoxicity and pharmacokinetics of total and lactone forms of 9-nitrocamptothecin (9-NC), an effective antineoplastic drug, after intravenous injection of drug incorporated into poly (DL-lactic-glycolic acid) nanoparticles (NPs). Drug-loaded NPs (9-NC.NP) were prepared by the nanoprecipitation method and examined for particle characteristics and in-vitro release in phosphate buffered saline. The best formulation showed a narrow size with an average diameter of 207+/-26 nm and a drug loading of more than 33.5%. The drug release profile showed a sustained 9-NC release up to 160 h. For a pharmacokinetic study, the concentration of 9-NC as the lactone form (9-NC.lac) and as the total of the lactone and carboxylate forms (9-NC.tot) in plasma was... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1699521 Wed, 13 Aug 2008 07:29:33 +0100 1699521 http://www.medworm.com/index.php?rid=1691154&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18685420%26dopt%3DAbstract Authors: Siemionow K, Lieberman IH PURPOSE OF REVIEW: Recent advances in the diagnosis and treatment of many types of cancers have prolonged and improved the quality of life for cancer patients. With increased survival, metastatic spinal lesions are becoming much more of a functional and clinical problem. RECENT FINDINGS: Percutaneous vertebral augmentation techniques and image-guided focused beam radiotherapy have recently evolved and show promising results in the treatment of metastatic spinal lesion. SUMMARY: Vertebral augmentation and radiosurgery are minimally invasive options for the treatment of metastatic lesions of the spine. When combined, these treatment modalities offer predictable pain control and limit deformity progression. PMID: 18685420 [PubMed - in process] (Sourc... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1691154 Sat, 09 Aug 2008 07:27:04 +0100 1691154 http://www.medworm.com/index.php?rid=1681770&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18677153%26dopt%3DAbstract Authors: Conner P, Lundström E, von Schoultz B Valid evidence from randomized-controlled trials indicates that breast cancer risk is increased with combined estrogen/progestogen use and that such treatment implies a risk greater than that of estrogen alone. Overall, risk estimates from observational studies are somewhat higher than in randomized-controlled trials but remain modest as compared with other risk factors even after long-term treatment. For combined estrogen/progestogen therapy, risk increases gradually to reach statistical significance after 4 to 5 years. Apart from its many beneficial health effects, the safety data for use of estrogen alone are quite reassuring. The only justifications for progestogen addition are for bleeding control and endometrial protection. At p... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1681770 Wed, 06 Aug 2008 07:29:12 +0100 1681770 http://www.medworm.com/index.php?rid=1676487&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18670273%26dopt%3DAbstract Authors: Horikawa Y, Gu J, Wu X PURPOSE OF REVIEW: The present article reviews recent reports on molecular epidemiological studies for exploring susceptibility genes for bladder cancer, with particular focus on gene-gene and gene-environmental interactions. RECENT FINDINGS: Recent large case-control studies and meta-analyses have confirmed that N-acetyl transferase2 slow acetylator and glutathione S-transferase Mu null genotype were modest susceptibility factors for bladder cancer, with probable interactions between N-acetyl transferase2 slow acetylator and smoking. Several interesting studies using a multigenic pathway-based genotyping approach and novel statistical tools showed significant interactions among potential functional single nucleotide polymorphisms in DNA repair pathway g... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1676487 Mon, 04 Aug 2008 07:13:38 +0100 1676487 http://www.medworm.com/index.php?rid=1676486&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18670274%26dopt%3DAbstract Authors: Lodde M, Fradet Y PURPOSE OF REVIEW: To review the most recent publications focusing on the use of genetic markers (DNA, RNA and nucleosides) in urine and serum and provide an opinion on their potential utility for screening, diagnosis and prognosis of urothelial carcinoma. RECENT FINDINGS: Several studies have shown the diagnostic utility of urine tests based on improved microsatellite analysis of loss-of-heterozygosity, detection of fibroblast growth factor receptor 3 mutations, detection of single RNA and multiple gene signatures as well as nucleoside profiles. Although of interest, all these studies lack appropriate controls and validation before being considered as serious candidate clinical biomarkers.The presence of fibroblast growth factor receptor 3 mutations in tumor... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1676486 Mon, 04 Aug 2008 07:13:32 +0100 1676486 http://www.medworm.com/index.php?rid=1676485&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18670275%26dopt%3DAbstract Authors: Schmidbauer J, Lindenau G PURPOSE OF REVIEW: Nonmuscle invasive bladder cancer represents a heterogeneous disease due to different natural history of its various appearances. The purpose of this article is to review recent literature regarding follow-up strategies. RECENT FINDINGS: Management of nonmuscle invasive bladder cancer has become more complex in respect to diagnosis, treatment and follow-up. Follow-up should therefore be based on individual patient-risk assessment. In addition to improved diagnosis by fluorescence-guided cystoscopy and other new diagnostic tools like optical-coherence tomography management has concentrated on optimizing different concepts of intravesical therapy. SUMMARY: The intent of nonmuscle invasive bladder cancer management is to control recurr... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1676485 Mon, 04 Aug 2008 07:13:29 +0100 1676485 http://www.medworm.com/index.php?rid=1667694&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18662423%26dopt%3DAbstract This article addresses the benefits of the combined use of music therapy and reflexology. Two case studies are presented to illustrate the application and benefits of this dual approach for patients and their families regarding adjustment to the end of life in the presence of anxiety and cognitive impairment. PMID: 18662423 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1667694 Thu, 31 Jul 2008 07:30:44 +0100 1667694 http://www.medworm.com/index.php?rid=1644829&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18642151%26dopt%3DAbstract Authors: Gajski G, Garaj-Vrhovac V Bee venom (BV) has been known to have therapeutic applications in traditional medicine to treat variety of diseases. It is also known that bee venom possesses anti-inflammatory and anticancer effects and that it can inhibit proliferation and induces apoptosis in cancer cells, but there is lack of information regarding genotoxicity of whole bee venom on normal human cells. In the present study, peripheral blood human lymphocytes from healthy donor were exposed in vitro to different concentration (5, 10, 25, 50 and 100 mu g/mL) of whole bee venom at different time periods (1, 6 and 24 hours). The single cell gel electrophoresis (SCGE) assay was used to evaluate the genotoxicity towards human cells. Results showed statistically significant increase in DN... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1644829 Wed, 23 Jul 2008 07:19:07 +0100 1644829 http://www.medworm.com/index.php?rid=1638715&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18528864%26dopt%3DAbstract In this study, we investigated for the first time the effects and possible mechanisms of action of lariciresinol on hormone responsive mammary cancer in vivo in dimethylbenz[a]anthracene induced mammary cancer in rats, and in human MCF-7 breast cancer xenografts in athymic mice. For tumor bearing rats, lariciresinol (3 or 15 mg/kg of body weight) or vehicle was administered p.o. daily for 9 weeks. For E2-maintained ovariectomized athymic mice bearing orthotopic MCF-7 tumors, control diet (AIN-93G) or lariciresinol containing diet (AIN-93G supplemented with 20 or 100 mg of lariciresinol/kg of diet) was administered for 5 weeks. In both models, lariciresinol administration inhibited the tumor growth and tumor angiogenesis. In MCF-7 cells, enterolactone significantly inhibited the E2-stimulat... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638715 Sun, 20 Jul 2008 07:19:38 +0100 1638715 http://www.medworm.com/index.php?rid=1638714&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18537160%26dopt%3DAbstract We examined age-adjusted BC and MC incidence rates in 74 female populations around the world with cancer registries. Our analysis suggests that BC and MC rates are inversely associated in a special mathematical form such that the product of BC rate and MC rate is approximately constant across world female populations. A differential equation model with solutions consistent to the observed inverse association was derived. BC and MC rates were modeled as functions of an exposure level to unspecified common factors that influence the 2 rates. In conjunction with previously reported evidence, we submit a hypothesis that BC etiology may have an appreciable link with microbial exposures (and/or immunological responses to them), the lack of which, especially in early life, may elevate BC risk. ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638714 Sun, 20 Jul 2008 07:19:31 +0100 1638714 http://www.medworm.com/index.php?rid=1638713&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18546267%26dopt%3DAbstract Authors: Zhang X, Zhang H, Tighiouart M, Lee JE, Shin HJ, Khuri FR, Yang CS, Chen ZG, Shin DM One of the mechanisms of the antitumor activity of green tea (-)-epigallocatechin-3-gallate (EGCG) is associated with its effect on epidermal growth factor receptor (EGFR)-mediated signaling transduction pathways. We investigated whether combining EGCG with the EGFR-tyrosine kinase inhibitor (EGFR-TKI) erlotinib may augment erlotinib-induced cell growth inhibition of squamous cell carcinoma of the head and neck (SCCHN) in a mouse xenograft model. In vitro studies with 5 head and neck cancer cell lines revealed that synergistic cell growth inhibition by the combination of EGCG and erlotinib was associated with significantly greater inhibition of pEGFR and pAKT, increased activation of caspases ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638713 Sun, 20 Jul 2008 07:19:18 +0100 1638713 http://www.medworm.com/index.php?rid=1638712&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18546287%26dopt%3DAbstract Authors: Johnson KJ, Puumala SE, Soler JT, Spector LG Neuroblastoma (NB), a tumor of the sympathetic nervous system, is the most common infant malignancy. The etiology of NB is largely unknown. We explored the association between birth record variables and subsequent NB development in a population-based case-cohort study in Minnesota by linking the birth and cancer registries. NB cases included 155 children born during 1976-2004 who were diagnosed from 28 days through 14 years of age. The comparison group included 8,752 individuals randomly sampled from the birth cohort of cases. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Controlling for birth year and sex, maternal history of one fetal loss (HR = 1.7, 95% CI 1.2-2.... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638712 Sun, 20 Jul 2008 07:19:14 +0100 1638712 http://www.medworm.com/index.php?rid=1638711&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18546288%26dopt%3DAbstract Authors: Mahabir S, Schendel K, Dong YQ, Barrera SL, Spitz MR, Forman MR Studies of vitamin E and cancer have focused on the alpha-tocopherol form of the vitamin. However, other forms of vitamin E, in particular gamma-tocopherol may have unique mechanistic characteristics relevant to lung cancer prevention. In an ongoing study of 1,088 incident lung cancer cases and 1,414 healthy matched controls, we studied the associations between 4 tocopherols (alpha-, beta-, gamma-, and delta-tocopherol) in the diet and lung cancer risk. Using multiple logistic regression analysis, the adjusted odds ratios (OR) and 95% confidence intervals (CI) of lung cancer for increasing quartiles of dietary alpha-tocopherol intake were 1.0, 0.63 (0.50-0.79), 0.58 (0.44-0.76) and 0.39 (0.28-0.53), respectively (... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638711 Sun, 20 Jul 2008 07:19:09 +0100 1638711 http://www.medworm.com/index.php?rid=1638710&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18546290%26dopt%3DAbstract Authors: Su W, Necela BM, Fujiwara K, Kurakata S, Murray NR, Fields AP, Thompson EA We evaluated RS5444, a thiazolidinedione high affinity PPARgamma agonist, for the ability to inhibit colon carcinogenesis in azoxymethane (AOM)-treated mice. In our initial experiment, mice were treated with RS5444 during AOM treatment, and the drug was withdrawn 12 weeks after the last injection of AOM. RS5444 significantly inhibited aberrant crypt focus formation under these circumstances. Furthermore, exposure to RS5444 during the course of AOM treatment effectively blocked colon tumor formation after withdrawal of the agonist. PPARgamma expression and nuclear localization were reduced in adenomas. RS5444 did not inhibit DNA synthesis in tumor cells, suggesting that PPARgamma activity was impaired in... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638710 Sun, 20 Jul 2008 07:18:59 +0100 1638710 http://www.medworm.com/index.php?rid=1638709&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18546293%26dopt%3DAbstract This study has identified new candidate biomarkers and targets for the early diagnosis and treatment of ccRCC metastasis. PMID: 18546293 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638709 Sun, 20 Jul 2008 07:18:55 +0100 1638709 http://www.medworm.com/index.php?rid=1638708&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18548583%26dopt%3DAbstract This article reviews the evidence for the cancer preventive actions of statins and NSAIDs, as well as their possible synergistic action and the mechanisms involved. PMID: 18548583 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1638708 Sun, 20 Jul 2008 07:18:49 +0100 1638708 http://www.medworm.com/index.php?rid=1546158&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18060824%26dopt%3DAbstract This study is part of a larger effort to develop, implement, and test such methods and tools. To be successful, the design of methods and tools must be grounded in a solid understanding of the work practices within the domain of use; the research reported here focuses on developing that understanding. We adopted a user-centered approach to toolset design where we investigated the work of cancer researchers and used the results of that investigation as inputs into the development of design guidelines for new geovisualization and spatial analysis tools. Specifically, we conducted key informant interviews focused on use, or potential use, of geographic information, methods, and tools and complemented this with a systematic analysis of published, peer-reviewed articles on geospatial cancer res... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1546158 Thu, 26 Jun 2008 20:54:22 +0100 1546158 http://www.medworm.com/index.php?rid=1517779&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18431743%26dopt%3DAbstract Authors: Ramus SJ, Vierkant RA, Johnatty SE, Pike MC, Van Den Berg DJ, Wu AH, Pearce CL, Menon U, Gentry-Maharaj A, Gayther SA, Dicioccio RA, McGuire V, Whittemore AS, Song H, Easton DF, Pharoah PD, Garcia-Closas M, Chanock S, Lissowska J, Brinton L, Terry KL, Cramer DW, Tworoger SS, Hankinson SE, Berchuck A, Moorman PG, Schildkraut JM, Cunningham JM, Liebow M, Kjaer SK, Hogdall E, Hogdall C, Blaakaer J, Ness RB, Moysich KB, Edwards RP, Carney ME, Lurie G, Goodman MT, Wang-Gohrke S, Kropp S, Chang-Claude J, , , Webb PM, Chen X, Beesley J, Chenevix-Trench G, Goode EL, The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1517779 Sat, 14 Jun 2008 20:37:41 +0100 1517779 http://www.medworm.com/index.php?rid=1517778&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18449887%26dopt%3DAbstract We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was positively associated with clear cell tumors (Odds Ratio 2.3; 95% confidence interval 1.2-4.2) but not invasive endometrioid or mucinous tumors. Although there was no associ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1517778 Sat, 14 Jun 2008 20:37:38 +0100 1517778 http://www.medworm.com/index.php?rid=1517777&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18449888%26dopt%3DAbstract Authors: Danoy P, Michiels S, Dessen P, Pignat C, Boulet T, Monet M, Bouchardy C, Lathrop M, Sarasin A, Benhamou S Cigarette smoking is the major risk factor for lung cancer, and together with alcohol for head and neck (H--N) cancer. These genotoxics produced DNA damage and particularly double-strand breaks (DSB) that are removed by various repair pathways. To understand the initiation of these cancers, we performed a genotype analysis to correlate some variants in specific genes in a case-control study of lung and H-N cancers. In a discovery phase, we sequenced DNA samples of 32 healthy Caucasians to describe genetic variants in 30 genes involved in the repair of DSB and in DNA damage response. 625 variants were detected on 29 out of the 30 genes successfully screened by sequencing ex... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1517777 Sat, 14 Jun 2008 20:37:34 +0100 1517777 http://www.medworm.com/index.php?rid=1517776&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18452169%26dopt%3DAbstract Authors: Basu GD, Azorsa DO, Kiefer JA, Rojas AM, Tuzmen S, Barrett MT, Trent JM, Kallioniemi O, Mousses S S100P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. We have previously shown how elevated S100P levels in prostate cancer strongly correlate with progression to metastatic disease. In our study, we evaluated the functional significance of S100P expression on prostate tumor growth in vitro and in vivo. S100P levels were modulated by overexpressing S100P in PC3 prostate cancer cells and by silencing S100P levels in 22Rv1 prostate cancer cells. Overexpression of S100P in PC3 cells promoted cell growth, increased the percentage of S-phase cells, decreased basal apoptosis rate and promoted ancho... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1517776 Sat, 14 Jun 2008 20:37:31 +0100 1517776 http://www.medworm.com/index.php?rid=1517775&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18464258%26dopt%3DAbstract Authors: Yang JL, Qu XJ, Yu Y, Kohn EC, Friedlander ML We have previously reported that high-dose nifedipine had a selective antiproliferative effect on colon cancer cell lines deficient in DNA mismatch repair (MMR).We hypothesized that carboxyamidotriazole (CAI), a calcium channel blocker, would also have a selective inhibitory effect on colon cancer cell lines with DNA MMR deficiency. In addition, we speculated that this effect may also be seen in cell lines deficient in DNA MMR derived from other tumor types. Fourteen human cancer cell lines with and without DNA MMR derived from carcinomas of the colon, bladder, ovary and prostate were treated with CAI, vehicle or control drugs (nifedipine and 5-flurouracil). The effect of treatment on growth inhibition, invasion, apoptosis and cell... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1517775 Sat, 14 Jun 2008 20:37:27 +0100 1517775 http://www.medworm.com/index.php?rid=1517774&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18464259%26dopt%3DAbstract Authors: Giroux V, Lemay F, Bernatchez G, Robitaille Y, Carrier JC Clinical evidence suggests that estradiol replacement therapy reduces colon cancer risk in 'post'menopausal women. In colon epithelial cells, the estrogen receptor beta (ERbeta) is the predominant ER subtype and is thought to mediate the genomic effect of estrogens. The first aim of this study was to investigate the consequence of ERbeta deficiency on intestinal tumorigenesis in the Apc(Min/+) mouse model. Furthermore, to explore the biological mechanisms by which estrogens may influence the pathogenesis of colorectal cancer, we performed gene expression profiles in colonocytes from ovariectomized wild-type (WT) vs. ERbeta(-/-) mice, treated with estradiol (E(2)) or vehicle. Specifically in female, ERbeta deficiency was... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1517774 Sat, 14 Jun 2008 20:37:23 +0100 1517774 http://www.medworm.com/index.php?rid=1486770&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18386788%26dopt%3DAbstract Authors: Doecke J, Zhao ZZ, Pandeya N, Sadeghi S, Stark M, Green AC, Hayward NK, Webb PM, Whiteman DC, Rates of adenocarcinoma of the esophagus (EAC) and esophago-gastric junction (EGJAC) have increased rapidly in recent decades. The primary risk factors, gastro-esophageal acid reflux and smoking, are potentially genotoxic through the generation of N-nitroso compounds. The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is the major cellular defense against alkylating DNA damage. We compared patients with EAC (n = 263) or EGJAC (n = 303) with matched population controls (n = 1,337) for the frequency of 5 MGMT single nucleotide polymorphisms (SNPs) (rs12269324, rs12268840, L84F, I143V, K178R), as well as SNPs in DNA repair genes ERCC1 (N118N), XRCC1 (Q399R) and XPD (... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486770 Tue, 03 Jun 2008 15:38:32 +0100 1486770 http://www.medworm.com/index.php?rid=1486769&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18395892%26dopt%3DAbstract Authors: Santoro A, Gazzerro P, Malfitano AM, Pisanti S, Laezza C, Bifulco M PMID: 18395892 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486769 Tue, 03 Jun 2008 15:38:27 +0100 1486769 http://www.medworm.com/index.php?rid=1486768&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18398831%26dopt%3DAbstract Authors: Furue H, Kumimoto H, Matsuo K, Suzuki T, Hasegawa Y, Shinoda M, Sugimura T, Mitsudo K, Tohnai I, Ueda M, Tajima K, Ishizaki K It was reported that there are 2 haplotypes in natural killer complex (NKC) region. One of them could be divided by NKG2D polymorphism into 2 haplotype alleles (high and low natural killer (NK) cell activity) and were associated with overall cancer risks. However, its impact on a specific cancer is unclear. Therefore, by a case-control study, we analyzed the association between NKG2D genotype and aerodigestive tract cancer risk. Subjects were 502 aerodigestive tract cancer patients (276 with head and neck, 226 with esophageal) and 1,004 sex-age matched noncancer controls. Exposures to 2 lifestyle factors, smoking and drinking, were evaluated by a self-a... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486768 Tue, 03 Jun 2008 15:38:19 +0100 1486768 http://www.medworm.com/index.php?rid=1486767&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18398837%26dopt%3DAbstract We reported 6 genes (SOX1, PAX1, LMX1A, NKX6-1, WT1 and ONECUT1) more frequently methylated in SCC tissues (81.5, 94.4, 89.9, 80.4, 77.8 and 20.4%, respectively) than in their normal controls (2.2, 0, 6.7, 11.9, 11.1 and 0%, respectively; p < 0.0001). Parallel testing of HPV and PAX1 methylation in cervical swabs confers an improved sensitivity than HPV testing alone (80% vs. 66%) without compromising specificity (63% vs. 64%) for HSIL/SCC. Testing PAX1 methylation marker alone, the specificity for HSIL/SCC is 99%. The analysis of these novel DNA methylations may be a promising approach for the screening of cervical cancers. PMID: 18398837 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486767 Tue, 03 Jun 2008 15:38:13 +0100 1486767 http://www.medworm.com/index.php?rid=1486766&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18404671%26dopt%3DAbstract This study was the largest ever done that evaluates the cross-sectional accuracy of screening tests for cervical cancer precursors in developing countries. The merit of the study was that all screened subjects were submitted to confirmatory investigations avoiding to verification bias. A major finding was the consistently higher sensitivity but equal specificity of VILI compared with VIA. Nevertheless, some caution is warranted in the interpretation of observed accuracy measures, since a certain degree of gold standard misclassification cannot be excluded. Because of the correlation between visual screening tests and colposcopy and a certain degree of over-diagnosis of apparent CIN2+ by study pathologists, it is possible that both sensitivity and specificity of VIA and VILI were overestima... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486766 Tue, 03 Jun 2008 15:38:07 +0100 1486766 http://www.medworm.com/index.php?rid=1486765&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18425819%26dopt%3DAbstract Authors: Risch A, Plass C Lung cancer is the leading cause of cancer-related death and thus a major health problem. The efficiency of current treatment modalities for lung cancer depends strongly on the time of diagnosis, with better chances of survival if a tumor has been detected at an early stage. Thus, there is an urgent need for rapid and efficient early detection methods. Biomarkers represent a possible alternative to current, rather expensive, screening tools such as spiral computer tomography (CT), or may allow the identification of high risk groups for whom screening would be cost efficient. Although most lung cancers are the consequence of smoking, a substantial fraction of molecular-epidemiological studies point to high-prevalence, low-penetrance genetic polymorphisms as mod... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486765 Tue, 03 Jun 2008 15:38:02 +0100 1486765 http://www.medworm.com/index.php?rid=1486764&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18435416%26dopt%3DAbstract This study provided further evidence for differential anticancer potential among each silymarin constituent, which would have potential implications in devising better formulations of silymarin against prostate and other cancers. PMID: 18435416 [PubMed - indexed for MEDLINE] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486764 Tue, 03 Jun 2008 15:37:58 +0100 1486764 http://www.medworm.com/index.php?rid=1486763&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18513154%26dopt%3DAbstract Conclusions. @nbsp; Optimization of the design of immunization strategies for treatment of HPV depends substantially on the duration of vaccine-induced immunity. Given the uncertainty in estimating this duration, it may be prudent to assume a value close to the lower limit reported and adjust the program when more-accurate information for the length of vaccine-induced immunity becomes available. PMID: 18513154 [PubMed - as supplied by publisher] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486763 Tue, 03 Jun 2008 15:37:52 +0100 1486763 http://www.medworm.com/index.php?rid=1486762&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18514780%26dopt%3DAbstract CONCLUSIONS: SU11248 (sunitinib) sensitized pancreatic cancer to the cytotoxic effects of radiation. This compound is promising for future clinical trials with chemoradiation in pancreatic cancer. PMID: 18514780 [PubMed - in process] (Source: Cancer Control) Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486762 Tue, 03 Jun 2008 15:37:47 +0100 1486762 http://www.medworm.com/index.php?rid=1486771&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17975300%26dopt%3DAbstract In this study, we sought to determine whether adipose tissue regeneration can be induced in vivo using adipose-derived stromal cells (ASCs) from GFP mice. ASCs were isolated from inguinal fat pads of GFP mice, as described in our previous publication. After incubation in two passages in the control medium, the cells were incubated in the induction medium to induce adipogenesis. Induced ASCs were merged with fibrin glue, and the mixture was injected subcutaneously into the dorsum of athymic mice. Finally, specimens were harvested and analyzed morphologically and histologically. The regenerated tissue was macroscopically semitransparent and soft with slight angiogenesis. Fluorescence microscopy revealed that the specimens strongly emitted green fluorescence, suggesting that the transplanted ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1486771 Tue, 03 Jun 2008 15:35:40 +0100 1486771 http://www.medworm.com/index.php?rid=1474181&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18506182%26dopt%3DAbstract We examined the association between non-steroidal anti-inflammatory drug (NSAID) use and ovarian cancer by potential effect modifiers, parity and oral contraceptive use, in a population-based case-control study conducted in Wisconsin and Massachusetts. Women reported prior use of NSAIDs and information on risk factors in a telephone interview. A total of 487 invasive ovarian cancer cases and 2653 control women aged 20-74 years were included in the analysis. After adjustment for age, state of residence and other covariates, ever use of NSAIDs was inversely associated with ovarian cancer in never users of oral contraceptives (odds ratio (OR)=0.58, 95% confidence interval (CI) 0.42-0.80) but not for ever users (OR=0.98, 95% CI 0.71-1.35) (P-interaction=0.03). A reduced risk with NSAID use was... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1474181 Thu, 29 May 2008 14:14:20 +0100 1474181 http://www.medworm.com/index.php?rid=1474180&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18506189%26dopt%3DAbstract Authors: Myles P, Evans S, Lophatananon A, Dimitropoulou P, Easton D, Key T, Pocock R, Dearnaley D, Guy M, Edwards S, O'Brien L, Gehr-Swain B, Hall A, Wilkinson R, Eeles R, Muir K Exposure to ionising radiation is an established risk factor for many cancers. We conducted a case-control study to investigate whether exposure to low dose ionisation radiation from diagnostic x-ray procedures could be established as a risk factor for prostate cancer. In all 431 young-onset prostate cancer cases and 409 controls frequency matched by age were included. Exposures to barium meal, barium enema, hip x-rays, leg x-rays and intravenous pyelogram (IVP) were considered. Exposures to barium enema (adjusted odds ratio (OR) 2.06, 95% confidence interval (CI) 1.01-4.20) and hip x-rays (adjusted OR 2.23, ... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1474180 Thu, 29 May 2008 14:14:17 +0100 1474180 http://www.medworm.com/index.php?rid=1474179&cid=s_31096_6_f&fid=31096&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18506655%26dopt%3DAbstract Authors: Eckel HE, Raunik W, Rogatsch H Precancer (carcinoma in situ) or laryngeal intraepithelial neoplasia (LIN) is a non-invasive lesion that has genetic abnormalities, loss of cellular control functions, and some phenotypic characteristics of invasive cancer and that predicts for a substantial likelihood of developing invasive cancer. Several classifications have been proposed but none has received a total agreement. With regard to diagnosis, treatment and prognosis, these lesions differ substantially from infiltrating carcinoma. Known risk factors include cigarette smoking, viral infection with subtypes of the human papilloma virus, exposure to asbestos, and probably the gastro-oesophageal reflux disease. The diagnostic work-up usually includes indirect laryngoscopy with rigid tel... Cancer Control journals http://www.medworm.com/rss/comments.php?id=1474179 Thu, 29 May 2008 14:14:14 +0100 1474179