MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cancer' source. Wed, 08 Feb 2012 08:41:18 +0100 http://www.medworm.com/index.php?rid=5659425&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26175 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5659425 Sun, 05 Feb 2012 12:57:00 +0100 5659425 http://www.medworm.com/index.php?rid=5659424&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27438 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5659424 Sun, 05 Feb 2012 12:56:15 +0100 5659424 http://www.medworm.com/index.php?rid=5659423&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27437 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5659423 Sun, 05 Feb 2012 12:56:14 +0100 5659423 http://www.medworm.com/index.php?rid=5659422&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27436 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5659422 Sun, 05 Feb 2012 12:56:13 +0100 5659422 http://www.medworm.com/index.php?rid=5647075&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27442 CONCLUSIONS:The current results suggested that several factors play a role in AML predisposition with possible joint effects. Risk profiles for AML differed by sex and WHO subtype. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647075 Wed, 01 Feb 2012 05:00:00 +0100 5647075 http://www.medworm.com/index.php?rid=5647074&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27440 CONCLUSIONS:On average, old, sick, poor, and Medicare patients were less likely to be treated at high‐volume hospitals for uro‐oncologic surgery. Similarly, black patients were less likely to have a radical cystectomy at a high‐volume hospital, and female patients were less likely to have an Nx at a high‐volume hospital. Selective referral of individuals who are less likely to receive care at such institutions may represent a health care priority intended to optimize outcomes across all population strata. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647074 Wed, 01 Feb 2012 05:00:00 +0100 5647074 http://www.medworm.com/index.php?rid=5647073&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26513 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647073 Wed, 01 Feb 2012 05:00:00 +0100 5647073 http://www.medworm.com/index.php?rid=5647072&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26514 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647072 Wed, 01 Feb 2012 05:00:00 +0100 5647072 http://www.medworm.com/index.php?rid=5647084&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27432 CONCLUSIONS:Women remain under‐represented in sex‐nonspecific biomedical research, whereas men's representation in sex‐specific research increased substantially. Psychosocial research trends suggest movement from research questions supporting traditional stereotypes that women feel and men act. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647084 Tue, 31 Jan 2012 05:00:00 +0100 5647084 http://www.medworm.com/index.php?rid=5647083&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27428 CONCLUSIONS:This study shows that E7974 once every 21‐day cycle shows antitumor activity in patients with refractory solid tumors. The recommended phase 2 dose is 0.45 mg/m2. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647083 Tue, 31 Jan 2012 05:00:00 +0100 5647083 http://www.medworm.com/index.php?rid=5647082&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27422 CONCLUSIONS:The incremental harms of adjuvant chemotherapy with 5FU/oxaliplatin versus 5FU alone were modest in patients with stage III colon cancer who were insured by Medicare and Medicaid. The additional harms in patients aged ≥75 years largely were restricted to outpatient events and did not extend to an increased rate of hospitalization or early death. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647082 Tue, 31 Jan 2012 05:00:00 +0100 5647082 http://www.medworm.com/index.php?rid=5647081&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27408 CONCLUSIONS:The overall incidence of ACC is declining. The noted differences in survival based on sex, marital status, site of origin, and treatment intervention require further investigation. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647081 Tue, 31 Jan 2012 05:00:00 +0100 5647081 http://www.medworm.com/index.php?rid=5647080&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27397 CONCLUSIONS:TM continues to be prevalent. Estimates of personal benefit were not usually meant to report facts, it remains unknown whether respondents in the current study had TMis. Although they are not more vulnerable, phase 1 participants need improved understanding of key TM concepts, with attention to risks that are not present in standard of care. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647080 Tue, 31 Jan 2012 05:00:00 +0100 5647080 http://www.medworm.com/index.php?rid=5647079&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27392 CONCLUSIONS:Good prediction of survival in addition to high reproducibility and sensitivity made pyrosequencing the best among the 5 techniques tested in this study. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647079 Tue, 31 Jan 2012 05:00:00 +0100 5647079 http://www.medworm.com/index.php?rid=5647078&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27388 CONCLUSIONS:This nationwide study suggests that disparities based on insurance status for patients undergoing surgery for spinal metastases may be attributable to a higher acuity of presentation. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647078 Tue, 31 Jan 2012 05:00:00 +0100 5647078 http://www.medworm.com/index.php?rid=5647077&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26728 CONCLUSIONS:More fatal cancers, particularly prostate, cervical, and oral cancer in men were detected among blacks, especially in central Georgia, where health behavior and social/economic factors were worse. MIRs are an efficient indicator of survival and provide insight into racial cancer disparities. Additional examination of geographic determinants of cancer fatality in Georgia as indicated by MIRs is warranted. Cancer 2012. © 2012 American Cancer Society (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647077 Tue, 31 Jan 2012 05:00:00 +0100 5647077 http://www.medworm.com/index.php?rid=5647076&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26679 CONCLUSIONS:The current results indicated that the prevalence of CML will continue to increase to reach a near plateau prevalence 35 times the annual incidence. These estimates should be considered in health care policies and in the design of future studies in CML. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5647076 Tue, 31 Jan 2012 05:00:00 +0100 5647076 http://www.medworm.com/index.php?rid=5638108&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27416 CONCLUSIONS:Neoadjuvant docetaxel and bevacizumab is safe, and results in reductions in both tumor volume and serum PSA, in men with high‐risk localized prostate cancer. The role of neoadjuvant chemotherapy in prostate cancer, and perioperative antiangiogenic therapy in general, requires further elucidation through ongoing and planned trials. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638108 Sun, 29 Jan 2012 12:48:22 +0100 5638108 http://www.medworm.com/index.php?rid=5628125&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26538 Cancer patients are often still smoking at the time of diagnosis. Cessation interventions may need to be tailored by cancer type. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5628125 Thu, 26 Jan 2012 12:50:54 +0100 5628125 http://www.medworm.com/index.php?rid=5638122&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27411 CONCLUSIONS:The strong association between increased copy number of key ALK signals and percentage of positive cells suggests that the <100% rate of cellular positivity in ALK+ tumors is due to technical factors, not biological factors. In ALK+ tumors, neither the percentage of positive cells nor signal copy number appear to be informative variables for predicting benefit from ALK inhibition. The inverse relationship between fused and isolated red copy number suggests ALK+ may be a distinct “near‐diploid” subtype of NSCLC that develops before significant chromosomal aneusomy occurs. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638122 Thu, 26 Jan 2012 05:00:00 +0100 5638122 http://www.medworm.com/index.php?rid=5638121&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27409 CONCLUSIONS:The results support the hypothesis that the dominant molecular oncogenes in NSCLC are associated with different biological behaviors manifesting as distinct patterns of metastatic spread at the time of diagnosis. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638121 Thu, 26 Jan 2012 05:00:00 +0100 5638121 http://www.medworm.com/index.php?rid=5638120&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27402 ALK‐positive nonsmall cell lung cancer represents a unique molecular subset with distinct clinical characteristics. With the availability of effective therapy, developing sensitive diagnostic methods has become an urgent priority. See pages 000‐000. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638120 Thu, 26 Jan 2012 05:00:00 +0100 5638120 http://www.medworm.com/index.php?rid=5638119&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26730 CONCLUSIONS:Although RPI.4610 demonstrated a well‐tolerated safety profile, its lack of clinical efficacy precludes this drug from further development. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638119 Thu, 26 Jan 2012 05:00:00 +0100 5638119 http://www.medworm.com/index.php?rid=5638118&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26729 AbstractDespite the use of PSA, Gleason score, and T‐category as prognosticators in intermediate‐risk prostate cancer, 20–40% of patients will fail local therapy. In order to optimize treatment approaches for intermediate‐risk patients, additional genetic prognosticators are needed. Previous reports using array comparative genomic hybridization (aCGH) in radical prostatectomy cohorts suggested a combination of allelic loss of the PTEN gene on 10q and allelic gain of the c‐MYC gene on 8q were associated with metastatic disease. We tested whether copy number alterations (CNAs) in PTEN (allelic loss) and c‐MYC (allelic gain) were associated with biochemical relapse following modern‐era, image‐guided radiotherapy (mean dose 76.4 Gy). We used aCGH analyses validated by fluoresce... Cancer journals http://www.medworm.com/rss/comments.php?id=5638118 Thu, 26 Jan 2012 05:00:00 +0100 5638118 http://www.medworm.com/index.php?rid=5638117&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26718 AbstractPersonalized medicine based on predictive markers linked to drug response, it is hoped, will lead to improvements in outcomes and avoidance of unnecessary treatment in squamous cell carcinoma of the head and neck (SCCHN). Recent research has shown that expression of ERCC1 may predict resistance to treatment with platinum agents. Future testing for this marker may help select the optimal type of chemotherapy. Infection with human papillomavirus (HPV) is associated with less aggressive disease and better prognosis in locally advanced SCCHN treated with chemoradiation or radiation alone; HPV‐positive patients may ultimately benefit from less intensive, less toxic therapy. K‐RAS mutations, occurring in about 40% of colorectal cancers and associated with lack of benefit from epiderm... Cancer journals http://www.medworm.com/rss/comments.php?id=5638117 Thu, 26 Jan 2012 05:00:00 +0100 5638117 http://www.medworm.com/index.php?rid=5638115&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26529 CONCLUSIONS:For patients with extensive or multiple local relapses or when surgery alone would result in a large burden of residual disease or major functional loss, the addition of moderate‐dose adjuvant radiotherapy provided excellent local control while maintaining good function with low treatment‐related morbidity. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638115 Thu, 26 Jan 2012 05:00:00 +0100 5638115 http://www.medworm.com/index.php?rid=5638114&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27435 CONCLUSIONS:The results support the study hypothesis and highlight the importance of SNPs within miRNA‐dependent regulatory regions. Further studies on the role exerted by NUP210 and KIAA0182 in colorectal carcinogenesis are warranted. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638114 Thu, 26 Jan 2012 05:00:00 +0100 5638114 http://www.medworm.com/index.php?rid=5638113&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27430 CONCLUSIONS:Short‐term administration of exogenous ghrelin at the start of cisplatin‐based chemotherapy stimulated food intake and minimized adverse events. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638113 Thu, 26 Jan 2012 05:00:00 +0100 5638113 http://www.medworm.com/index.php?rid=5638112&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27429 CONCLUSIONS:Clofarabine plus low‐dose cytarabine alternating with decitabine in consolidation is active in older patients with newly diagnosed AML. The benefits of a prolonged consolidation remain unproven. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638112 Thu, 26 Jan 2012 05:00:00 +0100 5638112 http://www.medworm.com/index.php?rid=5638111&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27424 CONCLUSIONS:The current results indicated that the highest level of lymph node involvement may be used to stratify the outcome of patients who have NSCLC with pN1 status. Patients with pN1 status who had only level 13/14 lymph node metastasis had an intermediate 5DFS rate between that of patients with pN0 status and other patients with pN1 status. Routine examination of level 13/14 lymph nodes is important for accurate pathologic staging and for the predicting clinical outcome of patients with NSCLC. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638111 Thu, 26 Jan 2012 05:00:00 +0100 5638111 http://www.medworm.com/index.php?rid=5638110&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27421 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638110 Thu, 26 Jan 2012 05:00:00 +0100 5638110 http://www.medworm.com/index.php?rid=5638109&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27415 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5638109 Thu, 26 Jan 2012 05:00:00 +0100 5638109 http://www.medworm.com/index.php?rid=5619716&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27413 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5619716 Mon, 23 Jan 2012 12:59:08 +0100 5619716 http://www.medworm.com/index.php?rid=5619715&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27412 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5619715 Mon, 23 Jan 2012 12:59:06 +0100 5619715 http://www.medworm.com/index.php?rid=5628126&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26545 CONCLUSIONS:After diagnosis, a substantial minority of patients with lung and colorectal cancers continued smoking. Patients with lung cancer had higher rates of smoking at diagnosis and after diagnosis; whereas patients with colorectal cancer were less likely to quit smoking after diagnosis. Factors that were associated with continued smoking differed between lung and colorectal cancer patients. Future smoking‐cessation efforts should examine differences by cancer type, particularly when comparing cancers for which smoking is a well established risk factor versus cancers for which it is not. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5628126 Mon, 23 Jan 2012 05:00:00 +0100 5628126 http://www.medworm.com/index.php?rid=5608195&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27423 CONCLUSIONS:Patients with advanced cancer did not change care preferences after viewing the video, but fewer wanted CPR or ventilation. Documented code status was inconsistent with patient preferences. Patients were more knowledgeable after the video, reported that the video was acceptable, and said they would recommend it to others. The current results indicated that this type of video may enable patients to visualize “goals of care,” enriching patient understanding of worsening health states and better informing decision making. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608195 Tue, 17 Jan 2012 05:00:00 +0100 5608195 http://www.medworm.com/index.php?rid=5608194&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27419 CONCLUSIONS:Therapy generally followed accepted standards for 2004. Findings in particular tumor sites and stages may reflect the variability that still exists for the treatment of HNC. The use of taxanes and cetuximab is expected to increase based on new evidence of benefit. Reducing treatment‐related toxicities and long‐term functional deficits will be critical and especially important with the increase in human papillomavirus‐related cancers. In addition, further attempts to improve survival for older patients are needed. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608194 Tue, 17 Jan 2012 05:00:00 +0100 5608194 http://www.medworm.com/index.php?rid=5608193&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27417 CONCLUSIONS:The aberrant methylation of a combination of marker genes present in oral rinse samples was used to detect OSCC with >90% sensitivity and specificity. The detection of methylated marker genes from oral rinse samples has great potential for the noninvasive detection of OSCC. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608193 Tue, 17 Jan 2012 05:00:00 +0100 5608193 http://www.medworm.com/index.php?rid=5608192&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27414 CONCLUSIONS:In osteosarcoma, age 18 to 30 years is associated with a statistically significant poorer outcome because of an increased rate of relapse. Poorer outcome in adolescent and young adult patients is not explained by tumor location, histologic response, or metastatic disease at presentation. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608192 Tue, 17 Jan 2012 05:00:00 +0100 5608192 http://www.medworm.com/index.php?rid=5608191&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27401 CONCLUSIONS:In general, EOL RT was received infrequently, was delivered more commonly to younger patients with more advanced disease, and often was not completed as planned. There also was considerable variation in its use among National Comprehensive Cancer Network institutions. Next steps include expanding this research to other cancers and settings and investigating the clinical benefit of such treatment. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608191 Tue, 17 Jan 2012 05:00:00 +0100 5608191 http://www.medworm.com/index.php?rid=5608190&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27398 CONCLUSIONS:Young men undergoing proton therapy for treatment of prostate cancer have excellent outcomes with respect to erectile dysfunction, urinary incontinence, and other health‐related quality of life parameters during the first 2 years after treatment. Longer follow‐up is needed to confirm these findings. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608190 Tue, 17 Jan 2012 05:00:00 +0100 5608190 http://www.medworm.com/index.php?rid=5608189&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26734 CONCLUSIONS:Results suggest that vaccination against HER‐2/neu is safe and well tolerated and induces decline and/or eradication of HER‐2/neu expression. These findings warrant further exploration of HER‐2/neu vaccination in estrogen‐independent breast cancer and highlight the need to target additional tumor‐associated antigens and pathways. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608189 Tue, 17 Jan 2012 05:00:00 +0100 5608189 http://www.medworm.com/index.php?rid=5608188&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26687 CONCLUSIONS:This research is the first known body of work to apply the concept of INRT to limited‐stage DLBCL. Reducing the field size from IFRT to INRT≤5 cm maintains a low marginal recurrence risk with no impact on overall outcome. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608188 Tue, 17 Jan 2012 05:00:00 +0100 5608188 http://www.medworm.com/index.php?rid=5608187&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26683 CONCLUSIONS:The OSNA assay can be used for routine clinical SLNB, and its assessment for volume of metastasis may be a powerful predictive factor for non‐SLN metastasis. Further studies with more patients are needed to confirm the usefulness of this assay for selection in the clinical setting of patients who do not need axillary dissection. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608187 Tue, 17 Jan 2012 05:00:00 +0100 5608187 http://www.medworm.com/index.php?rid=5608186&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27420 CONCLUSIONS:A new prognostic model based on these factors was built that segregated patients into 3 distinct risk categories independent of International Prognostic Scoring System (IPSS) score. This model is independent from the IPSS, further refines IPSS‐based prognostication, and may be used to develop of risk‐adapted therapeutic approaches for patients with hypocellular MDS. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608186 Tue, 17 Jan 2012 05:00:00 +0100 5608186 http://www.medworm.com/index.php?rid=5608185&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27418 CONCLUSIONS:Standard‐dose ibritumomab tiuxetan combined with BEAM high‐dose chemotherapy is safe and possibly more effective than BEAM alone as a conditioning regimen for ASCT in the era of rituximab‐containing chemotherapy regimens. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608185 Tue, 17 Jan 2012 05:00:00 +0100 5608185 http://www.medworm.com/index.php?rid=5608184&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27410 AbstractCancer is an emerging public health problem in Africa. About 715,000 new cancer cases and 542,000 cancer deaths occurred in 2008 on the continent, with these numbers expected to double in the next 20 years simply because of the aging and growth of the population. Furthermore, cancers such as lung, female breast, and prostate cancers are diagnosed at much higher frequencies than in the past because of changes in lifestyle factors and detection practices associated with urbanization and economic development. Breast cancer in women and prostate cancer in men have now become the most commonly diagnosed cancers in many Sub‐Saharan African countries, replacing cervical and liver cancers. In most African countries, cancer control programs and the provision of early detection and treatme... Cancer journals http://www.medworm.com/rss/comments.php?id=5608184 Tue, 17 Jan 2012 05:00:00 +0100 5608184 http://www.medworm.com/index.php?rid=5608183&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27403 CONCLUSIONS:The age‐incidence patterns observed suggested a common initiation of GCTs in embryonic/fetal life with variable rates of tumor progression as a result of subsequent events that may be site specific. The authors concluded that future genetic studies should consider GCTs from all sites to enable a better understanding of their etiology. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608183 Tue, 17 Jan 2012 05:00:00 +0100 5608183 http://www.medworm.com/index.php?rid=5608181&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27400 CONCLUSIONS:With 5 years of follow‐up, APBI produced clinical outcomes and patterns of failure comparable to those achieved with whole breast irradiation. Patients who developed an IBTR after APBI had excellent 3‐year survival outcomes after salvage treatments. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608181 Tue, 17 Jan 2012 05:00:00 +0100 5608181 http://www.medworm.com/index.php?rid=5608180&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27391 CONCLUSIONS:The results of this study indicate that ALK fusions also exist in adult RCC cases without uncommon backgrounds. These findings confirm the potential of ALK inhibitor therapy for selected cases of RCC. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608180 Tue, 17 Jan 2012 05:00:00 +0100 5608180 http://www.medworm.com/index.php?rid=5608179&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27389 CONCLUSIONS:Breast cancer survivors from racially and ethnically diverse populations have lower levels of PA and higher rates of obesity that are generally associated with poorer HRQOL. Culturally sensitive PA and weight loss interventions may improve these lifestyle characteristics and result in improved HRQOL. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608179 Tue, 17 Jan 2012 05:00:00 +0100 5608179 http://www.medworm.com/index.php?rid=5608178&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27378 CONCLUSIONS:The current results indicated that it is possible to safely resume HDMTX therapy after glucarpidase treatment for HDMTX‐induced acute kidney injury. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608178 Tue, 17 Jan 2012 05:00:00 +0100 5608178 http://www.medworm.com/index.php?rid=5608177&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27377 CONCLUSIONS:ER status and multifocality of the residual tumor after NAC were independent predictors of IBTR after BCT. The MDAPI was barely adaptable to the study patients in terms of predicting IBTR. Patients with ER‐positive and HER2‐negative tumors had a favorable prognosis, whereas patients who developed IBTR after NAC had significantly worse overall survival. The authors propose a new IBTR prognostic index using the 2 factors that were identified as predictive of IBTR: ER status and multifocality of the residual tumor. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608177 Tue, 17 Jan 2012 05:00:00 +0100 5608177 http://www.medworm.com/index.php?rid=5608176&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26733 CONCLUSIONS:This approach suggests the existence of >2 subsets of high‐grade pleomorphic STS, each with distinct clinical behavior. A composite gene set such as that described here may be useful to stratify STS in clinical trials, and may be of practical utility in patient management. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608176 Tue, 17 Jan 2012 05:00:00 +0100 5608176 http://www.medworm.com/index.php?rid=5608175&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26638 CONCLUSIONS:ITC is rare and aggressive. The current results indicated that its treatment should include total thyroidectomy and high‐dose radioiodine for all patients and neck dissections for patients with lymph node disease. Early diagnosis and close surveillance are essential in the management of patients with ITC. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608175 Tue, 17 Jan 2012 05:00:00 +0100 5608175 http://www.medworm.com/index.php?rid=5608174&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27382 CONCLUSIONS:The current results indicated that ALTENS treatment for radiation‐induced xerostomia can be delivered uniformly in a cooperative, multicenter setting and produces possible beneficial treatment response. Given these results, the phase 3 component of this study was initiated. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5608174 Sun, 15 Jan 2012 05:00:00 +0100 5608174 http://www.medworm.com/index.php?rid=5596986&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27379 CONCLUSIONS:More frequent prostate‐specific antigen testing for black and low‐income males could potentially reduce the prostate cancer mortality gap through earlier diagnosis of tumors that otherwise may become metastatic. More aggressive treatment of prostate cancer, especially in poor communities, might also reduce the gap. Cancer 2012; © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5596986 Sun, 15 Jan 2012 05:00:00 +0100 5596986 http://www.medworm.com/index.php?rid=5581031&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26471 CONCLUSIONS:Many parents communicate their BRCA1/2 test results to young offspring. Parents' perceptions of offspring responses appear to vary by offspring age and parent test result. A better understanding of how young offspring respond to information about hereditary risk for adult cancer could provide opportunities to optimize adaptive psychosocial responses to risk information and performance of health behaviors, in adolescence and throughout an at‐risk life span. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5581031 Fri, 13 Jan 2012 12:46:51 +0100 5581031 http://www.medworm.com/index.php?rid=5596988&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26665 CONCLUSIONS:This population‐based study demonstrates that the factors which are predictive of survival at baseline lose significance after one year of survival. Conditional survival estimates allow clinicians to provide survivors with more meaningful prognostic estimates that may impact surveillance schedules and streamline adjuvant therapy decisions and design of future clinical trials. Cancer 2012; © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5596988 Fri, 13 Jan 2012 05:00:00 +0100 5596988 http://www.medworm.com/index.php?rid=5596987&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27407 CONCLUSIONS:No difference was observed in the presence or absence of mitoses, a marker of tumor proliferation, in SPM and MPM. Because it has been demonstrated that the presence of mitosis is a powerful prognostic marker, the current findings suggested that the tumors behave similarly in patients with SPM and patients with MPM. The authors concluded that differences in tumor thickness and prognosis between SPM and MPM more likely are caused by factors other than tumor biology, such as increased surveillance. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5596987 Fri, 13 Jan 2012 05:00:00 +0100 5596987 http://www.medworm.com/index.php?rid=5571984&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26742 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5571984 Sun, 08 Jan 2012 12:56:19 +0100 5571984 http://www.medworm.com/index.php?rid=5571983&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27387 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5571983 Sun, 08 Jan 2012 12:56:18 +0100 5571983 http://www.medworm.com/index.php?rid=5571982&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27386 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5571982 Sun, 08 Jan 2012 12:56:17 +0100 5571982 http://www.medworm.com/index.php?rid=5571977&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27405 CONCLUSIONS.The current spatiotemporal prediction model is adequate to provide reasonable estimates of case counts. To project the estimated case counts ahead 4 years, the vector autoregressive model is recommended to be the best temporal projection method for producing estimates closest to the observed case counts. Cancer 2012;. © 2012 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5571977 Sun, 08 Jan 2012 12:47:47 +0100 5571977 http://www.medworm.com/index.php?rid=5571979&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26658 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5571979 Wed, 04 Jan 2012 05:00:00 +0100 5571979 http://www.medworm.com/index.php?rid=5559469&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27399 CONCLUSIONS:The current results indicated that disparities exist for Asian women with breast cancer who reside in the United States compared with NHW groups and among Asian subgroups. Differences in presenting clinicopathologic features may affect DSS rates, suggesting that further investigation of these disparities is warranted to increase early detection and treatment for specific subgroups. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559469 Tue, 03 Jan 2012 05:00:00 +0100 5559469 http://www.medworm.com/index.php?rid=5559468&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27394 CONCLUSIONS:The results from this study indicated that focal salvage therapy is a potential strategy for localized recurrence after radiotherapy that may reduce the harms resulting from whole‐gland salvage therapies. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559468 Tue, 03 Jan 2012 05:00:00 +0100 5559468 http://www.medworm.com/index.php?rid=5559467&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27393 CONCLUSIONS:The current data suggested that activated RhoA promotes VEGF expression and hypoxia‐induced angiogenesis through the up‐regulation of MDM2 to decrease p53 stability. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559467 Tue, 03 Jan 2012 05:00:00 +0100 5559467 http://www.medworm.com/index.php?rid=5559466&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27376 CONCLUSION:TN subtype has a statistically significant association with an increased risk of residual tumor. This suggests the putative increase in the risk of local failure in TN patients may be related to increased residual tumor burden. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559466 Tue, 03 Jan 2012 05:00:00 +0100 5559466 http://www.medworm.com/index.php?rid=5559465&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26737 CONCLUSIONS:Toward the goal of individualizing cancer chemotherapy, the current study identified novel SNPs and genes associated with capecitabine sensitivity that are potentially informative and testable in any patient regardless of ethnicity. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559465 Tue, 03 Jan 2012 05:00:00 +0100 5559465 http://www.medworm.com/index.php?rid=5559464&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26695 CONCLUSIONS:Although the pathologic inclusion criteria of contemporary adjuvant trials have notable differences, all 6 adjuvant trials demonstrated high predictive accuracy of DP. Overall, 43% to 59% of patients included for the adjuvant trials would develop DP, whereas 6% to 18% of patients excluded from the trials would develop DP during follow‐up. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559464 Tue, 03 Jan 2012 05:00:00 +0100 5559464 http://www.medworm.com/index.php?rid=5559463&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26677 CONCLUSIONS:SES, assessed by either individual‐level education or neighborhood measures, was associated with risk of CRC even after accounting for other risk factors. The relationship between SES and CRC was strongest in the rectum and weakest in the right colon. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559463 Tue, 03 Jan 2012 05:00:00 +0100 5559463 http://www.medworm.com/index.php?rid=5559462&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26675 CONCLUSIONS:AMVAC is safe and appears to be a well‐tolerated and effective NAC regimen for MIBC. It minimizes delays to definitive treatment and produces excellent pathological and radiological response rates. It is an appropriate comparator for future randomized trials. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559462 Tue, 03 Jan 2012 05:00:00 +0100 5559462 http://www.medworm.com/index.php?rid=5559461&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26660 CONCLUSIONS:Bortezomib combined with modified R‐CHOP produced high response rates without substantial increases in toxicity. A phase 2 study of R‐CHOP and bortezomib given at this established MTD is currently ongoing. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559461 Tue, 03 Jan 2012 05:00:00 +0100 5559461 http://www.medworm.com/index.php?rid=5559460&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27390 CONCLUSIONS:This large population‐based study adds new insights into the descriptive epidemiology of primary spinal cord, spinal meninges, and cauda equina tumors by providing in‐depth analyses of the incidence of these tumors on a national level. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5559460 Sun, 01 Jan 2012 05:00:00 +0100 5559460 http://www.medworm.com/index.php?rid=5544188&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26581 CONCLUSIONS:Our study shows that functional SNPs in the STK15 gene are associated with higher rate of recurrence, higher likelihood of chemoratiotherapy‐resistance, shorter DFS, and shorter MTS. Confirmation of our data and understanding the mechanisms through which STK15 functional SNPs mediate resistance to chemoradiotherapy are warranted. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544188 Wed, 28 Dec 2011 04:29:04 +0100 5544188 http://www.medworm.com/index.php?rid=5544198&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26736 CONCLUSIONS:DNMT3b was linked significantly to a poor prognosis for patients with esophageal cancer. Moreover, the current results indicated that targeting this enzyme may be a promising strategy for treating esophageal cancer, as evidenced by inhibited aggressive tumor behavior and treatment resistance. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544198 Tue, 27 Dec 2011 05:00:00 +0100 5544198 http://www.medworm.com/index.php?rid=5544197&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27396 CONCLUSIONS:Analysis of MYC gene rearrangement along with BCL2 and BCL6 is critical in identifying high‐risk patients with poor prognosis. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544197 Tue, 27 Dec 2011 05:00:00 +0100 5544197 http://www.medworm.com/index.php?rid=5544196&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27383 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544196 Tue, 27 Dec 2011 05:00:00 +0100 5544196 http://www.medworm.com/index.php?rid=5544195&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27381 CONCLUSIONS:Extranodal involvement affects the prognosis of patients undergoing R‐CHOP therapy for DLBCL. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544195 Tue, 27 Dec 2011 05:00:00 +0100 5544195 http://www.medworm.com/index.php?rid=5544194&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27380 CONCLUSIONS:Medicaid status was associated with unfavorable survival, even after adjusting for confounders. The findings reflect the vulnerability of Medicaid beneficiaries and possible inadequacies in the process of care. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544194 Tue, 27 Dec 2011 05:00:00 +0100 5544194 http://www.medworm.com/index.php?rid=5544193&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27375 CONCLUSIONS:The current results indicated that providing a method for documenting the business case for CCOP or other PBRN involvement will contribute to the long‐term sustainability and expansion of these programs by improving providers' understanding of the financial implications of participation. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544193 Tue, 27 Dec 2011 05:00:00 +0100 5544193 http://www.medworm.com/index.php?rid=5544192&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27374 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544192 Tue, 27 Dec 2011 05:00:00 +0100 5544192 http://www.medworm.com/index.php?rid=5544191&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27373 CONCLUSIONS:The current results indicated that RT may offer a significant survival benefit for patients with ATRT and that patients aged ≤3 years may derive more benefit from initial RT compared with older children. The authors concluded that prospective clinical trials are needed to examine the role of RT in the initial management of ATRT in patients aged <3 years. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544191 Tue, 27 Dec 2011 05:00:00 +0100 5544191 http://www.medworm.com/index.php?rid=5544190&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26692 CONCLUSIONS:Enzastaurin combined with bevacizumab‐based therapy is tolerable, but does not improve PFS during maintenance therapy in patients with MCRC compared with bevacizumab‐based therapy alone. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544190 Tue, 27 Dec 2011 05:00:00 +0100 5544190 http://www.medworm.com/index.php?rid=5544189&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26634 CONCLUSIONS:Data from this study demonstrated that establishing a unified AYA oncology program can lead to improved clinical trial enrollment for patients who are treated at medical oncology centers. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5544189 Tue, 27 Dec 2011 05:00:00 +0100 5544189 http://www.medworm.com/index.php?rid=5515099&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26282 CONCLUSIONS:Tumor cell expression of ER‐α was found to be a negative prognostic factor for treatment outcomes in both women and men. Expression of PR and AR was not associated with outcomes. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515099 Mon, 19 Dec 2011 01:27:00 +0100 5515099 http://www.medworm.com/index.php?rid=5515098&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27371 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515098 Mon, 19 Dec 2011 01:26:38 +0100 5515098 http://www.medworm.com/index.php?rid=5515097&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27370 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515097 Mon, 19 Dec 2011 01:26:36 +0100 5515097 http://www.medworm.com/index.php?rid=5515096&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27369 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515096 Mon, 19 Dec 2011 01:26:35 +0100 5515096 http://www.medworm.com/index.php?rid=5515095&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27368 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515095 Mon, 19 Dec 2011 01:26:34 +0100 5515095 http://www.medworm.com/index.php?rid=5515061&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26676 CONCLUSIONS:In this study, the authors documented the benefits of a therapeutic group by teleconference, a novel way to provide support for African American women with breast cancer. Further research should include a behavioral outcome, such as treatment adherence. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515061 Mon, 19 Dec 2011 01:18:44 +0100 5515061 http://www.medworm.com/index.php?rid=5515093&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26726 CONCLUSIONS:The serum IL‐10 level was identified as an independent prognostic factor for unresectable HCC. The current findings suggested that an elevated IL‐10 level may be related to hepatic injury caused by cirrhotic processes rather than tumor load. The authors concluded that the IL‐10 level offers additional prognostic value to the existing tumor staging systems. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515093 Fri, 16 Dec 2011 05:00:00 +0100 5515093 http://www.medworm.com/index.php?rid=5515092&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26725 CONCLUSIONS:The responsiveness of ALDH1‐positive cells to chemotherapy in primary and metastatic lesions and its prognostic significance were clarified in patients with breast cancer. The authors concluded that ALDH1‐positive status may represent a surrogate marker as a new concept in patients with lymph node‐positive breast cancer. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515092 Fri, 16 Dec 2011 05:00:00 +0100 5515092 http://www.medworm.com/index.php?rid=5515091&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26724 CONCLUSIONS:Patients with BRAF or NRAS mutations were more likely than WT patients to have central nervous system involvement at the time they were diagnosed with distant metastatic disease. NRAS mutation status was identified as an independent predictor of shorter survival after a diagnosis of stage IV melanoma. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515091 Fri, 16 Dec 2011 05:00:00 +0100 5515091 http://www.medworm.com/index.php?rid=5515090&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26723 CONCLUSIONS:The current analysis provided additional level 2 evidence supporting the use of concurrent R‐EPOCH in patients with HIV‐associated lymphoma and a CD4 count >50/μL, and the results support the design of an ongoing phase 3 trial comparing concurrent R‐EPOCH with R‐CHOP in immunocompetent patients with diffuse large B‐cell lymphoma (National Clinical Trial no. NCT00118209). Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515090 Fri, 16 Dec 2011 05:00:00 +0100 5515090 http://www.medworm.com/index.php?rid=5515089&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26720 CONCLUSIONS:Statin use was associated with substantial protection against prostate cancer death, adding to the epidemiologic evidence for an inhibitory effect on prostate cancer. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515089 Fri, 16 Dec 2011 05:00:00 +0100 5515089 http://www.medworm.com/index.php?rid=5515088&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26719 CONCLUSIONS:The QOL of patients after maxillary swing salvage nasopharyngectomy was good. The current results indicated that attention must be paid to the factors that adversely affect QOL after surgery, such as palliative resection, and complications like trismus, palatal fistula and osteoradionecrosis. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515088 Fri, 16 Dec 2011 05:00:00 +0100 5515088 http://www.medworm.com/index.php?rid=5515087&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26716 CONCLUSIONS:The nomogram described here outperformed current strategies for survival prediction in breast cancer patients with BMs. Two additional advantages of this nomogram are its ability to predict individualized, 1‐, 3‐, and 5‐year survival for novel patients and its straightforward representations of the relative effects of each of 9 covariates on neurologic survival. This represents a potentially valuable alternative to current models of survival prediction in this patient population. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515087 Fri, 16 Dec 2011 05:00:00 +0100 5515087 http://www.medworm.com/index.php?rid=5515086&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26713 CONCLUSIONS:Among patients with newly diagnosed localized prostate cancer, those with low health literacy levels were more vulnerable to mental distress than those with higher health literacy levels, but physical well‐being was no different. These findings suggest that health literacy may be important in patients managing prostate cancer and the effects of treatment, and provide the hypothesis that supportive interventions targeting patients with lower health literacy may improve their HRQOL. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515086 Fri, 16 Dec 2011 05:00:00 +0100 5515086 http://www.medworm.com/index.php?rid=5515085&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26711 CONCLUSIONS:LVI provided a strong predictor of outcome in patients with invasive breast cancer and should be incorporated into breast cancer staging systems. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515085 Fri, 16 Dec 2011 05:00:00 +0100 5515085 http://www.medworm.com/index.php?rid=5515084&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26709 CONCLUSIONS:Pemetrexed has single‐agent activity in relapsed/refractory PCNSL. Toxicities were seen likely because of the higher than standard dose used. Further investigation of this agent or other multitargeted antifolates in PCNSL is warranted to determine optimal dose and efficacy in a more homogeneous population. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515084 Fri, 16 Dec 2011 05:00:00 +0100 5515084 http://www.medworm.com/index.php?rid=5515083&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26708 CONCLUSIONS:FCR induction therapy followed by a short maintenance phase is a highly effective regimen with acceptable toxicity. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515083 Fri, 16 Dec 2011 05:00:00 +0100 5515083 http://www.medworm.com/index.php?rid=5515082&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26707 CONCLUSIONS.SSE and PSE were identified as complementary early detection strategies, particularly in men aged >60 years, in whom both partial and full‐body PSE were associated with thinner tumors. Given the high rates of physician access, PSE may be a more practical approach for successful early detection in this subgroup with highest mortality. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515082 Fri, 16 Dec 2011 05:00:00 +0100 5515082 http://www.medworm.com/index.php?rid=5515081&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26706 CONCLUSIONS.Decreased melanoma risk perception and knowledge among low‐SES individuals and decreased physician communication regarding skin examinations of these individuals may be key components of the consistently observed socioeconomic gradient in mortality. The current findings suggest the need to raise melanoma awareness among lower‐SES patients and to increase physician awareness of socioeconomic disparities in clinical communication and care. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515081 Fri, 16 Dec 2011 05:00:00 +0100 5515081 http://www.medworm.com/index.php?rid=5515080&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26702 CONCLUSIONS:A targeted yoga intervention led to significant improvements in fatigue and vigor among breast cancer survivors with persistent fatigue symptoms. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515080 Fri, 16 Dec 2011 05:00:00 +0100 5515080 http://www.medworm.com/index.php?rid=5515079&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26684 CONCLUSIONS:AT/RT tumors in children carry a dismal prognosis. Age <2 years, metastasis at diagnosis, and strong claudin‐6 positivity appeared to be independent prognostic factors for outcome. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515079 Fri, 16 Dec 2011 05:00:00 +0100 5515079 http://www.medworm.com/index.php?rid=5515078&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26681 CONCLUSIONS:Cancer patients experienced numerous geographic and health care system challenges, resulting in significant delays in receiving diagnosis and treatment, even for cancers highly amenable to early intervention. This unacceptable and unethical situation is likely explained by limited knowledge about cancer among patients and health care professionals, government neglect, poverty, and reliance on traditional healers. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515078 Fri, 16 Dec 2011 05:00:00 +0100 5515078 http://www.medworm.com/index.php?rid=5515077&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26740 CONCLUSIONS:The demographics and clinical features of patients with ACC differ by disease site. The current results indicated that site may be an important predictor of survival for patients who present with localized disease but is less important for patients who present with regional disease. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515077 Fri, 16 Dec 2011 05:00:00 +0100 5515077 http://www.medworm.com/index.php?rid=5515076&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26738 CONCLUSIONS.The authors report a site‐specific series of patients with HN MCC who received RT. In this group of patients with adverse features, RT was well tolerated, and LRF was low. The propensity for MCC to recur at the edge of the treatment field suggests that generous margins are appropriate when RT is administered. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515076 Fri, 16 Dec 2011 05:00:00 +0100 5515076 http://www.medworm.com/index.php?rid=5515075&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26735 CONCLUSIONS:The frequency of therapy‐related ALL is higher than previously reported and has a poor prognosis, probably related to the high frequency of adverse risk features. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515075 Fri, 16 Dec 2011 05:00:00 +0100 5515075 http://www.medworm.com/index.php?rid=5515074&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26732 CONCLUSIONS:The use of the finasteride/flutamide combination is feasible, and results in PSA declines of ≥80% in 96% of patients with serologic progression after definitive local therapy. There were no unexpected toxicities, and the change in quality of life was mild. Further evaluation of this or a similar regimen in a controlled clinical trial is warranted. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515074 Fri, 16 Dec 2011 05:00:00 +0100 5515074 http://www.medworm.com/index.php?rid=5515073&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26731 CONCLUSIONS:These data do not support the prognostic utility of PET‐CT in pretreatment and interim treatment settings. A positive PET‐CT after the completion of therapy identifies a patient subset with an inferior PFS and a trend toward inferior OS. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515073 Fri, 16 Dec 2011 05:00:00 +0100 5515073 http://www.medworm.com/index.php?rid=5515072&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26717 CONCLUSIONS:Histologic tumor involvement of the SMV/PV is an independent predictor of both DFS and OS in patients with stage II PAC treated with neoadjuvant therapy and PD. Complete histologic evaluation of the resected SMV/PV is important for the prognosis in patients with PAC who received neoadjuvant therapy and PD. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515072 Fri, 16 Dec 2011 05:00:00 +0100 5515072 http://www.medworm.com/index.php?rid=5515071&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26694 CONCLUSIONS:Personalized pain goal is a simple patient‐reported outcome for pain goals. The majority of patients were capable of stating their desired level for pain relief. The median personalized pain goal was 3, and it was highly stable at follow‐up assessment. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515071 Fri, 16 Dec 2011 05:00:00 +0100 5515071 http://www.medworm.com/index.php?rid=5515070&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26693 CONCLUSIONS:The use of PORT for patients with low‐grade glioma has declined in the period from 1998 to 2006 for both low‐risk and high‐risk patients. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515070 Fri, 16 Dec 2011 05:00:00 +0100 5515070 http://www.medworm.com/index.php?rid=5515069&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26688 CONCLUSIONS:These data demonstrate that active surveillance represents a considerable cost savings over immediate treatment for prostate cancer in a theoretical cohort after 5 and 10 years of follow‐up. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515069 Fri, 16 Dec 2011 05:00:00 +0100 5515069 http://www.medworm.com/index.php?rid=5515068&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26685 CONCLUSIONS:There has been a stepwise improvement in the overall survival of patients with GBM between 2001 and 2007. This improvement has been confined to patients <70 years of age and has been most prominent among patients living in high‐income districts. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515068 Fri, 16 Dec 2011 05:00:00 +0100 5515068 http://www.medworm.com/index.php?rid=5515067&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27384 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515067 Fri, 16 Dec 2011 05:00:00 +0100 5515067 http://www.medworm.com/index.php?rid=5515066&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.27372 CONCLUSIONS:Extended field SRS was superior to conventional SRS in the local control of small recurrent lesions of glioblastoma, although a further device to suppress remote dissemination may be necessary to increase survival. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515066 Fri, 16 Dec 2011 05:00:00 +0100 5515066 http://www.medworm.com/index.php?rid=5515065&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26741 CONCLUSIONS.The TADA regimen yielded clinical responses in patients with PMF and MDS/MPN. To the authors' knowledge, this study represents the first trial targeting this patient population. The results indicated that it is reasonable to incorporate multiple novel agents in the treatment of these rare diseases. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515065 Fri, 16 Dec 2011 05:00:00 +0100 5515065 http://www.medworm.com/index.php?rid=5515064&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26701 CONCLUSIONS:DCE‐MRI was identified as a prognostic factor for EFS and overall survival before treatment on this trial and was indicative of a histologic response to neoadjuvant therapy. Further studies are needed to verify these findings with other treatment regimens and establish the potential role of DCE‐MRI in the development of risk‐adapted therapy for osteosarcoma. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515064 Fri, 16 Dec 2011 05:00:00 +0100 5515064 http://www.medworm.com/index.php?rid=5515063&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26697 CONCLUSIONS:Patients with either low‐ or intermediate‐grade tumors uniformly have favorable local control and survival. High histological grade, advanced stage, perineural invasion, positive surgical margins, and submandibular location all portend for poor outcomes in MEC. Further advances in therapy are needed to improve outcomes for high‐grade and advanced‐stage disease. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515063 Fri, 16 Dec 2011 05:00:00 +0100 5515063 http://www.medworm.com/index.php?rid=5515062&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26696 CONCLUSIONS:For patients with high‐risk, extremity STS, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery are sustained even with long‐term follow‐up. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5515062 Fri, 16 Dec 2011 05:00:00 +0100 5515062 http://www.medworm.com/index.php?rid=5504367&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26678 CONCLUSIONS:Diagnosis of 2 or more primary cancers (excluding nonmelanoma skin cancers) is associated with increased risk for poorer physical and mental health status over and above that associated with diagnosis of a single primary cancer. Survivors of multiple and single primary cancer diagnoses should be considered as distinct subgroups, and increased attention should be devoted to the unique status and needs of survivors of multiple primary cancer diagnoses. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5504367 Thu, 15 Dec 2011 05:00:00 +0100 5504367 http://www.medworm.com/index.php?rid=5504373&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26712 CONCLUSIONS:Further studies need to be performed to examine CD52 expression and function in HS as well as the role of alemtuzumab in a larger cohort of patients. However, the clinical impact of single‐agent alemtuzumab in the 2 patients described in this report was very encouraging. Given the toxicity and frequent inefficacy of conventional chemotherapy, patients with incompletely resected HS should be strongly considered for alemtuzumab therapy. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5504373 Tue, 13 Dec 2011 05:00:00 +0100 5504373 http://www.medworm.com/index.php?rid=5504372&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26700 CONCLUSIONS:The current results indicated a significant increase in the incidence of EATL in the United States, which may reflect the increasing seroprevalence of CD and better recognition of rare types of T‐cell lymphomas. The incidence may continue to rise given the large ratio of undiagnosed‐to‐diagnosed individuals with CD in the United States. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5504372 Tue, 13 Dec 2011 05:00:00 +0100 5504372 http://www.medworm.com/index.php?rid=5504371&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26699 CONCLUSIONS:In a select population, extreme hypofractionation with stereotactic radiosurgery was safe and effective for the treatment of low‐risk prostate adenocarcinoma. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5504371 Tue, 13 Dec 2011 05:00:00 +0100 5504371 http://www.medworm.com/index.php?rid=5504370&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26698 CONCLUSIONS:KLF4 may function as a tumor suppressor in cervical carcinoma by inhibiting cell growth and tumor formation. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5504370 Tue, 13 Dec 2011 05:00:00 +0100 5504370 http://www.medworm.com/index.php?rid=5504369&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26682 CONCLUSIONS:Resection of GI malignancy in cirrhotics is associated with poor early postoperative and transitional outcomes, with severity of liver disease being the primary determinant of postoperative mortality. These data suggest that GI cancer operations can be performed safely in well‐selected cirrhotic patients with mild liver dysfunction. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5504369 Tue, 13 Dec 2011 05:00:00 +0100 5504369 http://www.medworm.com/index.php?rid=5504368&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26680 CONCLUSIONS:Escalation of the WBRT dose beyond 30 Gy resulted in better outcomes, particularly for patients who had less radiosensitive tumors. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5504368 Tue, 13 Dec 2011 05:00:00 +0100 5504368 http://www.medworm.com/index.php?rid=5494637&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26432 CONCLUSIONS:Findings provide limited support for the view that changes in cognitive functioning in cancer survivors are attributable to chemotherapy administration and illustrate the importance of including a radiotherapy comparison group. Future research should seek to examine possible mechanisms that could explain the apparent prolonged impact of both chemotherapy and radiotherapy on cognitive functioning in breast cancer survivors. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5494637 Tue, 13 Dec 2011 01:26:14 +0100 5494637 http://www.medworm.com/index.php?rid=5476184&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26667 CONCLUSIONS:This study showed an association between MTHFR genotype and risk of clinically significant RP. Further study of MTHFR‐related pathways may provide insight into the mechanisms behind RP. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5476184 Wed, 07 Dec 2011 01:27:39 +0100 5476184 http://www.medworm.com/index.php?rid=5476185&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26670 Although several single‐nucleotide polymorphisms have been associated with radiation‐induced toxicity in candidate gene studies, there are many important limitations to such analyses. The primary limitations include the approach (candidate gene vs genome wide), small patient numbers, lack of a validation set, and subjective endpoints.See also pages 000–000. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5476185 Mon, 05 Dec 2011 05:00:00 +0100 5476185 http://www.medworm.com/index.php?rid=5468448&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26690 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468448 Sun, 04 Dec 2011 01:34:09 +0100 5468448 http://www.medworm.com/index.php?rid=5468447&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26705 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468447 Sun, 04 Dec 2011 01:33:45 +0100 5468447 http://www.medworm.com/index.php?rid=5468446&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26704 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468446 Sun, 04 Dec 2011 01:33:44 +0100 5468446 http://www.medworm.com/index.php?rid=5468445&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26703 (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468445 Sun, 04 Dec 2011 01:33:43 +0100 5468445 http://www.medworm.com/index.php?rid=5468432&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26632 CONCLUSIONS:These results confirm the 2‐factor structure of the SABIS‐G and provide evidence that this is a valid and reliable instrument to measure changes in body image and sexuality in women after a diagnosis of GC. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468432 Sun, 04 Dec 2011 01:25:37 +0100 5468432 http://www.medworm.com/index.php?rid=5468444&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26666 CONCLUSIONS:A select subset of mRCC patients achieving stable disease or better on VEGF‐targeted therapy can be observed off all therapy. Further prospective investigation is warranted. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468444 Fri, 02 Dec 2011 05:00:00 +0100 5468444 http://www.medworm.com/index.php?rid=5468443&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26637 CONCLUSIONS:The outcomes of 411 patients collected prospectively over 8 years strongly supported the efficacy of hyperbaric oxygen treatment for the 6 conditions evaluated. The response rates previously reported in numerous small series were supported by the responses achieved in this large, single‐center experience. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468443 Fri, 02 Dec 2011 05:00:00 +0100 5468443 http://www.medworm.com/index.php?rid=5468442&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26629 CONCLUSIONS:The research showed that the “sandwich” protocol of LVP combined with RT was a safe and effective treatment for localized nasal natural killer/T‐cell lymphoma, and the results warrant further investigation into this protocol. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468442 Fri, 02 Dec 2011 05:00:00 +0100 5468442 http://www.medworm.com/index.php?rid=5468441&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26627 CONCLUSIONS:Although the overall incidence of WM remained steady over time, significant increases in incidence were seen over the past 20 years in whites, in those aged 70 to 79 years, and in 3 geographic registry areas. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468441 Fri, 02 Dec 2011 05:00:00 +0100 5468441 http://www.medworm.com/index.php?rid=5468440&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26621 CONCLUSIONS:BCR‐ABL1 expression up‐regulated HO‐1, a survival factor for CML cells. This up‐regulation was more pronounced in blast crisis CML relative to early stage disease and was mediated by the NADPH oxidase components Rac1 and p47phox. The expression of p47phox was increased in BCR‐ABL1–expressing cells. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468440 Fri, 02 Dec 2011 05:00:00 +0100 5468440 http://www.medworm.com/index.php?rid=5468439&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26598 CONCLUSION:These findings indicate that ZNF217 overexpression is critical to growth and survival of OCCCs with ZNF217 gene amplification. Furthermore, they suggest that ZNF217 siRNA‐induced phenotypes depend on amplification status of OCCCs. Therefore, ZNF217‐targeted therapy may benefit OCCC patients with ZNF217 amplification. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468439 Fri, 02 Dec 2011 05:00:00 +0100 5468439 http://www.medworm.com/index.php?rid=5468438&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26593 CONCLUSIONS:Except for inconsequential differences in albumin and ZAP70 expression, there was no difference in the baseline characteristics between patients with CLL who had monoallelic or biallelic deletion of 13q. In addition, there was no significant difference in endpoints, including time to treatment. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468438 Fri, 02 Dec 2011 05:00:00 +0100 5468438 http://www.medworm.com/index.php?rid=5468437&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26560 CONCLUSIONS:Our results suggest that down‐regulation of miR‐200b could lead to E2F3 overexpression and in turn contribute to chemoresistance of lung adenocarcinoma cells to docetaxel. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468437 Fri, 02 Dec 2011 05:00:00 +0100 5468437 http://www.medworm.com/index.php?rid=5468436&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26512 CONCLUSION:Our study demonstrates that for patients with bone‐only metastases, zoledronic acid did not prolong PFS or OS. In patients with bone‐only metastasis, we could not demonstrate antitumor effects of zoledronic acid. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468436 Fri, 02 Dec 2011 05:00:00 +0100 5468436 http://www.medworm.com/index.php?rid=5468435&cid=s_33593_6_f&fid=33593&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fcncr.26664 CONCLUSIONS:On the basis of the relative lack of clinical activity, further development of ARRY‐520 as an antileukemic agent was halted. (Clinicaltrials.gov identifier NCT00637052). Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer) Cancer journals http://www.medworm.com/rss/comments.php?id=5468435 Fri, 02 Dec 2011 05:00:00 +0100 5468435