MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cardiovascular Drugs and Therapy' source. Wed, 17 Mar 2010 13:59:26 +0100 http://www.medworm.com/index.php?rid=3367109&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv16886p8t1382613%2F Conclusions  Our data demonstrated that, in our ex vivo model of myocardial ischaemia-reperfusion injury, AMPK activation in early reperfusion is associated with a reduction in infarct size. Content Type Journal ArticleDOI 10.1007/s10557-010-6222-3Authors Marta A. Paiva, University College London Hospitals and Medical School The Hatter Cardiovascular Institute 67 Chenies Mews London WC1E 6HX UKLino M. Gonçalves, Coimbra University Hospital and Coimbra Medical School Basic Research in Cardiology Unit, IBILI Coimbra PortugalLuis A. Providência, Coimbra University Hospital and Coimbra Medical School Basic Research in Cardiology Unit, IBILI Coimbra PortugalSean M. Davidson, University College London Hospitals and Medical School The Hatter Cardiovascular Institute 67 Che... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3367109 Sun, 14 Mar 2010 11:27:56 +0100 3367109 http://www.medworm.com/index.php?rid=3367110&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu21t4tt30182j7g6%2F Conclusion  Lowering blood pressure, either with eprosartan or other anti-hypertensives in hypertensive patients with diastolic dysfunction did not change diastolic function after 6 months of treatment, but was associated with a decrease of NT-proBNP. Content Type Journal ArticleDOI 10.1007/s10557-010-6221-4Authors Adriaan A. Voors, University Medical Centre Groningen Department of Cardiology PO Box 30.001 9700 RB Groningen The NetherlandsRuud M. van de Wal, St. Antonius Hospital Nieuwegein Nieuwegein The NetherlandsJasper W. L Hartog, University Medical Centre Groningen Department of Cardiology PO Box 30.001 9700 RB Groningen The NetherlandsRichard G. Vijn, Refaja Hospital Stadskanaal Stadskanaal The NetherlandsYoran M. Hummel, University Medical Centre Groninge... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3367110 Sun, 14 Mar 2010 11:27:55 +0100 3367110 http://www.medworm.com/index.php?rid=3360420&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgnr7304p37515785%2F Conclusion  A single high loading dose of rosuvastatin reduces the incidence of peri-procedural myocardial necrosis and infarction effectively. Content Type Journal ArticleDOI 10.1007/s10557-010-6224-1Authors Serkan Cay, Yuksek Ihtisas Heart-Education and Research Hospital Department of Cardiology Ankara TurkeyGoksel Cagirci, Ministry of Health Dışkapı Yıldırım Beyazıt Research and Educational Hospital Department of Cardiology Ankara TurkeyNihat Sen, Mustafa Kemal University, Faculty of Medicine Department of Cardiology Hatay TurkeyYucel Balbay, Yuksek Ihtisas Heart-Education and Research Hospital Department of Cardiology Ankara TurkeyTahir Durmaz, Ataturk Education and Research Hospital Department of Cardiology Ankara TurkeySinan Aydogdu, Yuksek Ihtisas Heart-Edu... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3360420 Thu, 11 Mar 2010 02:45:03 +0100 3360420 http://www.medworm.com/index.php?rid=3312807&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fru51066276210108%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10557-010-6219-yAuthors Andreas Skyschally, Institut für Pathophysiologie, Universitätsklinikum Essen Hufelandstraße 55 45122 Essen GermanyRainer Schulz, Institut für Pathophysiologie, Universitätsklinikum Essen Hufelandstraße 55 45122 Essen GermanyGerd Heusch, Institut für Pathophysiologie, Universitätsklinikum Essen Hufelandstraße 55 45122 Essen Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3312807 Thu, 25 Feb 2010 06:56:10 +0100 3312807 http://www.medworm.com/index.php?rid=3285200&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr15j21368332n0r3%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s10557-010-6218-zAuthors Huige Li, Johannes Gutenberg University Department of Pharmacology Obere Zahlbacher Strasse 67 55131 Mainz GermanyUlrich Förstermann, Johannes Gutenberg University Department of Pharmacology Obere Zahlbacher Strasse 67 55131 Mainz Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3285200 Wed, 17 Feb 2010 18:31:19 +0100 3285200 http://www.medworm.com/index.php?rid=3281050&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0794m3542l123520%2F Conclusions  Such effects of intracoronary levosimendan bolus administration during regional myocardial ischemia indicate the occurrence of cardio-protection by modulation of programmed form of cell death. Content Type Journal ArticleDOI 10.1007/s10557-010-6217-0Authors Elena Grossini, University of East Piedmont “A. Avogadro” Department of Clinical and Experimental Medicine, Physiology Section Via Solaroli 17 28100 Novara ItalyPhilippe Primo Caimmi, Ospedale Maggiore della Carità Department of Cardiac Surgery C.so Mazzini 18 28100 Novara ItalyFrancesca Platini, University of East Piedmont “A. Avogadro” Department of Food, Chemical, Pharmaceutical and Pharmacological Sciences (DISCAFF) Novara ItalyClaudio Molinari, University of East Piedmont “A. Avogadro�... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3281050 Tue, 16 Feb 2010 18:08:22 +0100 3281050 http://www.medworm.com/index.php?rid=3232817&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl80741k02q0867vu%2F Conclusions  These data clearly show that G-CSF treatment was unable to restore cardiac function impaired by myocardial infarction either with classical approach or long term low dose administration. Content Type Journal ArticleDOI 10.1007/s10557-010-6215-2Authors Ruy A. N. Louzada, UFRJ Laboratório de Cardiologia Celular e Molecular do Instituto de Biofísica Carlos Chagas Filho Rio de Janeiro CEP 21941-902 BrasilPatricia F. Oliveira, UFRJ Laboratório de Cardiologia Celular e Molecular do Instituto de Biofísica Carlos Chagas Filho Rio de Janeiro CEP 21941-902 BrasilJoao Paulo A. Cavalcanti-de-Albuquerque, EEFD—UFRJ Laboratório de Biologia do Exercício do Departamento de Biociências e Atividade Física Rio de Janeiro CEP 21941-599 BrasilLeandro Cunha-Carvalho, E... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3232817 Mon, 01 Feb 2010 18:05:47 +0100 3232817 http://www.medworm.com/index.php?rid=3228661&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx8646un371377l8t%2F Content Type Journal ArticleDOI 10.1007/s10557-010-6216-1Authors Jay N. Cohn, University of Minnesota Medical School Cardiovascular Division, Mayo Mail Code 508 420 Delaware Street Southeast Minneapolis MN 55455 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3228661 Fri, 29 Jan 2010 12:18:32 +0100 3228661 http://www.medworm.com/index.php?rid=3205797&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1244r0t027670181%2F Content Type Journal ArticleDOI 10.1007/s10557-009-6214-3Authors Robert S. Rosenson, SUNY Downstate Brooklyn NY USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3205797 Fri, 22 Jan 2010 10:11:47 +0100 3205797 http://www.medworm.com/index.php?rid=3121253&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc11320g806k30738%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6213-4Authors Heidi Noels, RWTH Aachen University Institute for Molecular Cardiovascular Research (IMCAR) Aachen GermanyChristian Weber, RWTH Aachen University Institute for Molecular Cardiovascular Research (IMCAR) Aachen Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3121253 Wed, 23 Dec 2009 22:54:49 +0100 3121253 http://www.medworm.com/index.php?rid=3121254&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu45344392n457171%2F Abstract  The combination of aspirin and clopidogrel is the mainstay antiplatelet therapy for acute coronary syndromes (ACS). However, the dosing of aspirin, the dosing of clopidogrel, the timing of clopidogrel initiation as well as the duration of clopidogrel therapy remain controversial matters. Clopidogrel resistance is an emerging concept with potential clinical implications. In the era of clopidogrel and bivalirudin, the role of glycoprotein IIb/IIIa antagonists is being challenged, yet they are still indicated in a select high-risk population. Concerning anticoagulant use in ACS, newer agents, bivalirudin and fondaparinux, have improved outcomes in comparison to heparin in patients managed with an invasive or conservative strategy, respectively. Combining multiple ant... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3121254 Wed, 23 Dec 2009 22:54:47 +0100 3121254 http://www.medworm.com/index.php?rid=3086020&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa750457014713866%2F Conclusion  These data indicate that montelukast inhibits neointimal hyperplasia in association with decreased expression of MMP-2 and MMP-9 independent of plasma lipid levels in atherosclerotic plaques after vascular injury in hyperlipidemic rabbits. Content Type Journal ArticleDOI 10.1007/s10557-009-6211-6Authors Dezhi Liu, Nanjing University School of Medicine Department of Neurology, Jinling Hospital 305# East Zhongshan Road Nanjing 210002 Jiangsu Province People’s Republic of ChinaSong Ge, Nanjing University School of Medicine Department of Neurology, Jinling Hospital 305# East Zhongshan Road Nanjing 210002 Jiangsu Province People’s Republic of ChinaGuangyi Zhou, Nanjing University School of Medicine Department of Neurology, Jinling Hospital 305# East Zhongshan... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3086020 Thu, 10 Dec 2009 00:12:34 +0100 3086020 http://www.medworm.com/index.php?rid=3080417&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx677m781r05215n5%2F Conclusions  The results of our study indicate that high dose aspirin can improve the atherosclerotic lesion and suppress the fractalkine expression in murine aorta. Content Type Journal ArticleDOI 10.1007/s10557-009-6210-7Authors Hong Liu, The Second Xiangya Hospital of Central South University Department of Geriatrics Changsha Hunan China 410011Deqian Jiang, The Second Xiangya Hospital of Central South University Department of Cardiology Changsha Hunan ChinaShebing Zhang, The Affiliated Yue Bei People’s Hospital of Shantou University Medical College Department of Cardiology Shaoguan Guangdong ChinaBaiqing Ou, The Hunan People’s Hospital Department of Cardiology Changsha Hunan China Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3080417 Mon, 07 Dec 2009 19:35:57 +0100 3080417 http://www.medworm.com/index.php?rid=3080418&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw971263304h85806%2F Conclusion  DPNCE elevated arterial cysteine and propionate, and increased myocardial concentration of CAC intermediates, but did not affect mechanical function or oxidative stress. Content Type Journal ArticleDOI 10.1007/s10557-009-6208-1Authors Takhar Kasumov, Case Western Reserve University Department Nutrition, School of Medicine Cleveland OH 44106 USANaveen Sharma, Case Western Reserve University Department Nutrition, School of Medicine Cleveland OH 44106 USAHazel Huang, Case Western Reserve University Department of Physiology & Biophysics, School of Medicine Cleveland OH 44106 USARajan S. Kombu, Case Western Reserve University Department Nutrition, School of Medicine Cleveland OH 44106 USAAndrea Cendrowski, Case Western Reserve University Department Nutrition, Sch... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3080418 Fri, 04 Dec 2009 21:19:06 +0100 3080418 http://www.medworm.com/index.php?rid=3040902&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fel0xu32535576527%2F Conclusions  The initial use of carperitide therapy safely reduces PCWP in ADHF patients with LVSD and baseline systolic BP may be useful for predicting the response to initial carperitide therapy for ADHF with LVSD. Content Type Journal ArticleDOI 10.1007/s10557-009-6207-2Authors Katsuya Kajimoto, Tokyo Women’s Medical University Department of Cardiology 8-1, Kawada-cho, Shinjuku-ku Tokyo 162-8666 JapanYukiko Sashida, Tokyo Women’s Medical University Department of Cardiology 8-1, Kawada-cho, Shinjuku-ku Tokyo 162-8666 JapanYuichiro Minami, Tokyo Women’s Medical University Department of Cardiology 8-1, Kawada-cho, Shinjuku-ku Tokyo 162-8666 JapanDai Yumino, Tokyo Women’s Medical University Department of Cardiology 8-1, Kawada-cho, Shinjuku-ku Tokyo 162-8666 Japa... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3040902 Wed, 25 Nov 2009 17:07:45 +0100 3040902 http://www.medworm.com/index.php?rid=3031766&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkhj2w15312357367%2F Abstract  The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively. Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6209-0Authors Huige... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=3031766 Tue, 24 Nov 2009 07:11:54 +0100 3031766 http://www.medworm.com/index.php?rid=2996832&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff12411n3230u5066%2F Conclusions  Lycopene can decrease the oxidative injury of endothelial cells induced by H2O2, can attenuate the expression of p53 and caspase-3 mRNA in injured cells, and can diminish the apoptosis of injured cells. These findings possibly explain in part why lycopene can prevent atherosclerotic cardiovascular diseases. Content Type Journal ArticleDOI 10.1007/s10557-009-6206-3Authors XiangYu Tang, Fujian Medical University and Fujian Provincial Institute of Coronary Disease Department of Cardiology, Union Hospital Fuzhou Fujian China 350001XiangDong Yang, University of South China Institute of cardiovascular Disease Hengyang Hunan China 421001YaFei Peng, Fujian Medical University and Fujian Provincial Institute of Coronary Disease Department of Cardiology, Union Hospita... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2996832 Fri, 13 Nov 2009 18:28:08 +0100 2996832 http://www.medworm.com/index.php?rid=2968571&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj525506t60273j14%2F Conclusion  These considerations suggest that novel therapies with a different mechanism of action, when used in combination with current antiplatelet agents, may provide more comprehensive inhibition of platelet activation and additional reductions in morbidity and mortality, potentially without incremental bleeding risk. Content Type Journal ArticleDOI 10.1007/s10557-009-6204-5Authors Marc Cohen, Newark Beth Israel Medical Center Division of Cardiology 201 Lyons Avenue at Osborne Terrace Newark NJ 07112 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2968571 Wed, 04 Nov 2009 20:59:42 +0100 2968571 http://www.medworm.com/index.php?rid=2951740&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2975063016m66r26%2F Conclusions  The calpain inhibitor N-Acetyl-Leu-Leu-Met attenuated apoptosis through a complicated network of apoptosis-related proteins, which may result in improvement of structural remodeling in atrial fibrillation. Content Type Journal ArticleDOI 10.1007/s10557-009-6199-yAuthors Yue Li, Harbin Medical University Department of Cardiology, the First Affiliated Hospital Harbin 150001 People’s Republic of ChinaZhi-Hua Gong, Harbin Medical University Department of Cardiology, the First Affiliated Hospital Harbin 150001 People’s Republic of ChinaLi Sheng, Harbin Medical University Department of Cardiology, the First Affiliated Hospital Harbin 150001 People’s Republic of ChinaYong-Tai Gong, Harbin Medical University Department of Cardiology, the First Affiliated Hosp... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2951740 Fri, 30 Oct 2009 18:24:38 +0100 2951740 http://www.medworm.com/index.php?rid=2936249&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn64wh077x7500151%2F Conclusion  In patients with heart failure and anemia, erythropoiesis stimulating agent therapy appears to have a positive effect on several important cardiovascular parameters, compared to control therapy. Large prospective randomized controlled trials are warranted to comprehensively evaluate the potential effects of erythropoiesis stimulating agents on clinical outcomes in heart failure patients with anemia. Content Type Journal ArticleDOI 10.1007/s10557-009-6203-6Authors Faramarz Tehrani, Cedars-Sinai Medical Center Cedars-Sinai Heart Institute 8700 Beverly Blvd, #5534 Los Angeles CA 90048 USAPavittarpaul Dhesi, Cedars-Sinai Medical Center Cedars-Sinai Heart Institute 8700 Beverly Blvd, #5534 Los Angeles CA 90048 USADaniel Daneshvar, Cedars-Sinai Medical Center Ce... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2936249 Tue, 27 Oct 2009 18:04:21 +0100 2936249 http://www.medworm.com/index.php?rid=2936250&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgl6u02t467207155%2F Abstract  Dyslipidaemia including decreased high density lipoprotein cholesterol concentration is one of several factors that have been implicated in increased cardiovascular risk. Since their introduction in the 1980s, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have emerged as the one of the best-selling class of medications to date, with numerous trials demonstrating powerful efficacy in preventing cardiovascular diseases. Although statins have been shown to modestly raise or not alter HDL-cholesterol, their effect on HDL subfractions and on HDL-associated enzymes including human paraoxonase-1 (PON1) has not yet been fully explored. This review summarizes the currently availabe data on the effect of statins on HDL subfractions and on PO... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2936250 Mon, 26 Oct 2009 18:09:25 +0100 2936250 http://www.medworm.com/index.php?rid=2917544&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpn025l9462244753%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6201-8Authors Michael H. Davidson, Radiant Research The University of Chicago Pritzker School of Medicine 515 North State Street, Suite 2700 Chicago IL 60654 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2917544 Wed, 21 Oct 2009 05:57:58 +0100 2917544 http://www.medworm.com/index.php?rid=2905987&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7222v321833n23n7%2F Conclusions  The present study showed, that use of statins is associated with a reduction in CEM, an emerging marker of clinical instability and plaque vulnerability in CAD patients. The pleiotropic effects of statins at the cell membrane level represent a promising novel direction for research in CAD. Content Type Journal ArticleDOI 10.1007/s10557-009-6202-7Authors Dimitrios N. Tziakas, Democritus University of Thrace University Cardiology Department, Medical School Voulgaroktonou 23 68100 Alexandroupolis GreeceGeorgios K. Chalikias, Democritus University of Thrace University Cardiology Department, Medical School Voulgaroktonou 23 68100 Alexandroupolis GreeceDimitrios Stakos, Democritus University of Thrace University Cardiology Department, Medical School Voulgarokton... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2905987 Fri, 16 Oct 2009 17:58:10 +0100 2905987 http://www.medworm.com/index.php?rid=2896113&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1877x42w10k3366%2F Conclusions  It is concluded that levosimendan is much more potent to relax norepinephrine-induced contraction of human IMA in comparison to its effect on human SV. It may have the potential to be used as a mixed inotropic/arteriodilator compound in several clinical settings including CABG in which it can increase cardiac contractility and prevent IMA vasospasm. Content Type Journal ArticleDOI 10.1007/s10557-009-6197-0Authors Hossein Mirkhani, Shiraz University of Medical Sciences Department of Pharmacology PO Box 71345-1649 Shiraz IranMasih Shafa, Shiraz University of Medical Sciences Department of surgery, Division of Cardiovascular Surgery Shiraz IranHajar Khazraei, Shiraz University of Medical Sciences Department of Pharmacology PO Box 71345-1649 Shiraz Iran ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2896113 Tue, 13 Oct 2009 20:35:09 +0100 2896113 http://www.medworm.com/index.php?rid=2877495&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3748p85x72v61806%2F Content Type Journal ArticleDOI 10.1007/s10557-009-6200-9Authors Uwe Lendeckel, Ernst-Moritz-Arndt University Institute of Medical Biochemistry and Molecular Biology Greifswald GermanyAndreas Goette, Otto-von-Guericke University Division of Cardiology, University Hospital Magdeburg Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2877495 Thu, 08 Oct 2009 07:05:50 +0100 2877495 http://www.medworm.com/index.php?rid=2873370&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9r81mg6033269g04%2F Conclusion  Our results suggest that resveratrol supplementation gender independently could improve the capacity of endothelial function and suppression of oxidative stress under physiological conditions. Resveratrol ingestion indicates a potential for cardiovascular health promotion. Content Type Journal ArticleDOI 10.1007/s10557-009-6198-zAuthors Selen Soylemez, Gazi University Department of Pharmacology, Faculty of Pharmacy Etiler, Ankara TurkeyAylin Sepici, Gazi University Department of Medical Biochemistry, Faculty of Medicine Besevler, Ankara TurkeyFatma Akar, Gazi University Department of Pharmacology, Faculty of Pharmacy Etiler, Ankara Turkey Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs a... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2873370 Wed, 07 Oct 2009 07:00:05 +0100 2873370 http://www.medworm.com/index.php?rid=2848067&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86w51660h475j864%2F In conclusion, it is possible to use β-blockers in HF patients even in the presence of lung function impairment, but their use should be guided by a combination of lung function evaluation and knowledge of the pharmacological properties of each molecule Content Type Journal ArticleDOI 10.1007/s10557-009-6195-2Authors Piergiuseppe Agostoni, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan ItalyPietro Palermo, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan ItalyMauro Contini, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan Italy Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2848067 Tue, 29 Sep 2009 16:56:52 +0100 2848067 http://www.medworm.com/index.php?rid=2848068&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F57vwqg3v02018t43%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10557-009-6196-1Authors Niels P. Riksen, Radboud University Nijmegen Medical Centre Department of Vascular Medicine and Pharmacology-Toxicology Geert Grooteplein 21 PO Box 9101 6500 HB Nijmegen The NetherlandsAbigail Wynne, University College London Medical School The Hatter Cardiovascular Institute London UKDerek M. Yellon, University College London Medical School The Hatter Cardiovascular Institute London UKDerek J. Hausenloy, University College London Medical School The Hatter Cardiovascular Institute London UK Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2848068 Tue, 29 Sep 2009 01:08:23 +0100 2848068 http://www.medworm.com/index.php?rid=2839934&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq025x3w4jt35043g%2F Content Type Journal ArticleDOI 10.1007/s10557-009-6193-4Authors Jay N. Cohn, University of Minnesota Medical School Cardiovascular Division, Mayo Mail Code 508 420 Delaware Street Southeast Minneapolis MN 55455 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2839934 Thu, 24 Sep 2009 16:46:00 +0100 2839934 http://www.medworm.com/index.php?rid=2810727&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv0041725prj2q706%2F Conclusions  In this study, we will investigate the improvement of coronary plaque with IVUS by treatment with two dihydropyridine CCBs in hypertensive patients undergoing elective PCI. This result will lead to the discovery of more effective drug therapy for inhibition of coronary events. Content Type Journal ArticleDOI 10.1007/s10557-009-6192-5Authors Katsumi Miyauchi, Juntendo University School of Medicine Department of Cardiology Tokyo JapanTakahiko Kojima, Juntendo University School of Medicine Department of Cardiology Tokyo JapanTakayuki Yokoyama, Juntendo University School of Medicine Department of Cardiology Tokyo JapanTakeshi Kurata, Juntendo University School of Medicine Department of Cardiology Tokyo JapanKen Yokoyama, Juntendo University School of Medicine ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2810727 Thu, 17 Sep 2009 23:34:18 +0100 2810727 http://www.medworm.com/index.php?rid=2810726&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F58575672j552624m%2F Conclusion  Endothelial cell seeding fails to prevent intimal hyperplasia following arterial injury in the rat carotid model. Content Type Journal ArticleDOI 10.1007/s10557-009-6191-6Authors Bertram J. Jobst, Regensburg University Medical Center Department of Internal Medicine II Franz-Josef-Strauß-Allee 11 Regensburg 93053 GermanyGuenter A. J. Riegger, Regensburg University Medical Center Department of Internal Medicine II Franz-Josef-Strauß-Allee 11 Regensburg 93053 GermanyDaniel P. Griese, Regensburg University Medical Center Department of Internal Medicine II Franz-Josef-Strauß-Allee 11 Regensburg 93053 Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2810726 Thu, 17 Sep 2009 23:34:18 +0100 2810726 http://www.medworm.com/index.php?rid=2810728&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftu74432402048246%2F Conclusions  Adding fenofibrate to primary statin therapy might be a useful strategy to address residual macrovascular and microvascular risk in type 2 diabetes. Content Type Journal ArticleDOI 10.1007/s10557-009-6190-7Authors George Steiner, University of Toronto Toronto General Hospital 200 Elizabeth Street Toronto ON M5G 2C4 Canada Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2810728 Wed, 16 Sep 2009 12:51:21 +0100 2810728 http://www.medworm.com/index.php?rid=2700821&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4443058131q875u3%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s10557-009-6187-2Authors John P. Lekakis, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceAthanassios Protogerou, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceChristos Papamichael, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceGeorgia Vamvakou, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceIgnatios Ikonomidis, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceFrancesco Fici, 2nd University of Naples Excellent Center for Cardiovascular Disease, Department of Experimental Medicine(P... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2700821 Wed, 12 Aug 2009 15:17:26 +0100 2700821 http://www.medworm.com/index.php?rid=2685960&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6r1543839p087404%2F Conclusion  Further clinical trials (including head to head comparison with other conventional anti-arrhythmics) are still required to determine the place of dronedarone in the management of AF. The present review focuses on basic and clinical aspects of dronedarone, a novel agent for the management of AF. Content Type Journal ArticleDOI 10.1007/s10557-009-6189-0Authors Kenan Yalta, Cumhuriyet University Cardiology Department Sivas 58100 TurkeyOkan Onur Turgut, Cumhuriyet University Cardiology Department Sivas 58100 TurkeyMehmet Birhan Yılmaz, Cumhuriyet University Cardiology Department Sivas 58100 TurkeyAhmet Yılmaz, Cumhuriyet University Cardiology Department Sivas 58100 TurkeyIzzet Tandogan, Cumhuriyet University Cardiology Department Sivas 58100 Turkey Jou... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2685960 Sun, 09 Aug 2009 07:16:49 +0100 2685960 http://www.medworm.com/index.php?rid=2668957&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F62085x6541706g10%2F Conclusions  Abnormal betaine excretion is common in patients treated with bezafibrate. Bezafibrate appears to exacerbate betaine loss, which will cause a rise in plasma homocysteine. Betaine supplementation could be considered in conjunction with fibrate therapy. Content Type Journal ArticleDOI 10.1007/s10557-009-6188-1Authors Michael Lever, Canterbury Health Laboratories Biochemistry Unit P.O. Box 151 Christchurch 8140 New ZealandPeter M. George, Canterbury Health Laboratories Biochemistry Unit P.O. Box 151 Christchurch 8140 New ZealandSandy Slow, Canterbury Health Laboratories Biochemistry Unit P.O. Box 151 Christchurch 8140 New ZealandJane L. Elmslie, Canterbury Health Laboratories Biochemistry Unit P.O. Box 151 Christchurch 8140 New ZealandRussell S. Scott, Christc... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2668957 Mon, 03 Aug 2009 18:06:09 +0100 2668957 http://www.medworm.com/index.php?rid=2661538&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl41l606r14w10583%2F Conclusion  Despite experimental data that demonstrates that angiotensin receptor antagonists reduce cellular oxidant stress and inflammation, olmesartan was not different than amlodipine in changing ox-NEFA and inflammatory markers in hypertensive subjects with the metabolic syndrome. Content Type Journal ArticleDOI 10.1007/s10557-009-6185-4Authors Robert S. Rosenson, Department of Medicine Divisions of Endocrinology, Diabetes and Metabolism, and Cardiovascular Medicine SUNY Downstate, 450 Clarkson Avenue, Box 1205 Brooklyn NY 11203 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2661538 Thu, 30 Jul 2009 07:57:00 +0100 2661538 http://www.medworm.com/index.php?rid=2651202&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8855368170107n30%2F Conclusions  Twelve weeks of treatment with atorvastatin significantly decreased serum sICAM-1, CRP and vWF levels, and improved the FMD, LVEF and 6MWT outcomes. Inhibition of inflammation, alleviating endothelium damage and endothelial dysfunction might comprise part of the underlying mechanisms leading to the improvement of LV function and exercise tolerance in patients with IDCM. Content Type Journal ArticleDOI 10.1007/s10557-009-6186-3Authors Miao Liu, Huazhong University of Science and Technology Department of paediatrics, Wuhan Union Hospital Wuhan 430022 ChinaFang Wang, Huazhong University of Science and Technology Department of paediatrics, Wuhan Union Hospital Wuhan 430022 ChinaYanrong Wang, Huazhong University of Science and Technology Department of paediatri... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2651202 Mon, 27 Jul 2009 22:57:37 +0100 2651202 http://www.medworm.com/index.php?rid=2631727&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3252535263362294%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6182-7Authors David S. Grimes, Royal Blackburn Hospital Blackburn BB2 3HH UK Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2631727 Sat, 18 Jul 2009 22:32:36 +0100 2631727 http://www.medworm.com/index.php?rid=2603638&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7794245005224u30%2F Conclusions  Olprinone but not isoflurane protects the heart against myocardial infarction in type 2 diabetic rats. The olprinone-induced cardioprotective effect is mediated by the PI3K-Akt pathway but not PKC or m-KATP channels. Content Type Journal ArticleDOI 10.1007/s10557-009-6184-5Authors Shuhei Matsumoto, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanSungsam Cho, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanShinya Tosaka, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanHiroyuki Ureshino, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 J... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2603638 Tue, 14 Jul 2009 11:15:00 +0100 2603638 http://www.medworm.com/index.php?rid=2578041&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm0h17600q2v08h55%2F Conclusions  BNP, UACR, UAER, and LVMI, among others, have been increasingly established as valid surrogate markers with significant value for hypertension prognosis and therapy. The benefits of using surrogate markers to gauge the effectiveness of hypertension therapy in reducing renal and cardiac complications can be seen in improved morbidity and mortality. Content Type Journal ArticleDOI 10.1007/s10557-009-6177-4Authors Alan S. Maisel, Veterans Affairs San Diego Healthcare System Coronary Care Unit and Heart Failure Program 3350 La Jolla Village Drive, Cardiology Section, mc 9111A San Diego CA 92161 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2578041 Mon, 06 Jul 2009 17:08:46 +0100 2578041 http://www.medworm.com/index.php?rid=2578042&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc855172u26430826%2F Conclusions  In conclusion, NE increased collagen gene and protein expressions in CF culture. This effect is likely mediated through α-receptor as they were normalized by pretreatment with carvedilol and doxazosin, but not β-blockers such as propranolol and metoprolol. Also, TGF-β1 doesn’t seem to play a role in carvedilol inhibition of NE induced fibrogenesis. Content Type Journal ArticleDOI 10.1007/s10557-009-6183-6Authors Ka-Bik Lai, Li Ka Shing Institute of Health and Science, Institute of Vascular Medicine, and Division of Cardiology, The Chinese University of Hong Kong Department of Medicine and Therapeutics, Prince of Wales Hospital Hong Kong Hong Kong SARJohn E. Sanderson, Li Ka Shing Institute of Health and Science, Institute of Vascular Medicine, and Div... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2578042 Mon, 06 Jul 2009 16:17:23 +0100 2578042 http://www.medworm.com/index.php?rid=2549591&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa842800nv81lx681%2F Conclusion  Vasopressin-receptor antagonists may prove useful in the treatment of HF; however, the exact role of these agents in the treatment of HF still requires further study. Content Type Journal ArticleDOI 10.1007/s10557-009-6180-9Authors Mitchell H. Rosner, University of Virginia Health System Division of Nephrology, Department of Medicine Box 800133 Charlottesville VA 22908 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2549591 Thu, 25 Jun 2009 07:41:16 +0100 2549591 http://www.medworm.com/index.php?rid=2487419&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F68361325182q7601%2F Conclusions  Our study shows that LPC, whose effectiveness on claudication is already known, has favourable effects in patients with CLI, since it reinforces the effects produced by PGE-1. Content Type Journal ArticleDOI 10.1007/s10557-009-6178-3Authors Glauco Milio, University of Palermo Department of Internal Medicine Cardiovascular and Nephro-Urological Diseases Via M. Rutelli 9-90143 Palermo ItalyGiuseppina Novo, University of Palermo Department of Internal Medicine Cardiovascular and Nephro-Urological Diseases Via M. Rutelli 9-90143 Palermo ItalyCaterina Genova, University of Palermo Department of Internal Medicine Cardiovascular and Nephro-Urological Diseases Via M. Rutelli 9-90143 Palermo ItalyPiero Luigi Almasio, University of Palermo Department of Internal and ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2487419 Tue, 23 Jun 2009 06:09:11 +0100 2487419 http://www.medworm.com/index.php?rid=2487420&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F97l0850542403817%2F Conclusion  This study has shown an effect of rosuvastatin on vitamin D metabolism, with an increase in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. This may be an important pleiotropic effect whereby rosuvastatin reduces mortality in patients with coronary artery disease. Further studies are needed to clarify the relationship between statins and vitamin D metabolism. Content Type Journal ArticleDOI 10.1007/s10557-009-6181-8Authors Bunyamin Yavuz, Department of Cardiology Kecioren Teaching and Research Hospital Ankara TurkeyDerun Taner Ertugrul, Department of Internal Medicine Kecioren Teaching and Research Hospital Ankara TurkeyHicran Cil, Department of Internal Medicine Kecioren Teaching and Research Hospital Ankara TurkeyNaim Ata, Department of Internal Med... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2487420 Sat, 20 Jun 2009 06:07:49 +0100 2487420 http://www.medworm.com/index.php?rid=2487421&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdr314m7ph3732201%2F Conclusions  The study provides experimental evidence that the combination of orotic acid and mildronate possesses additive pharmacological effects and that mildronate orotate might be considered as a powerful therapeutic agent facilitating recovery from ischemia-reperfusion injury. Content Type Journal ArticleDOI 10.1007/s10557-009-6179-2Authors Reinis Vilskersts, Latvian Institute of Organic Synthesis Aizkraukles Str. 21 Riga LV1006 LatviaEdgars Liepinsh, Latvian Institute of Organic Synthesis Aizkraukles Str. 21 Riga LV1006 LatviaJanis Kuka, Latvian Institute of Organic Synthesis Aizkraukles Str. 21 Riga LV1006 LatviaHelena Cirule, Latvian Institute of Organic Synthesis Aizkraukles Str. 21 Riga LV1006 LatviaMaris Veveris, Latvian Institute of Organic Synthesis Aizkr... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2487421 Thu, 18 Jun 2009 16:47:34 +0100 2487421 http://www.medworm.com/index.php?rid=2448865&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F79638142763254r2%2F Content Type Journal ArticleDOI 10.1007/s10557-009-6175-6Authors Jay N. Cohn, University of Minnesota Medical School ISCP Minneapolis MN 55455 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2448865 Thu, 28 May 2009 09:07:35 +0100 2448865 http://www.medworm.com/index.php?rid=2433651&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp5464551t661027t%2F Conclusion  In conclusion, we showed that prolonged reperfusion beyond 60 min was not useful for function assessment and did not change infarct size measurement, on Langendorff rat model of ischemia-reperfusion. Content Type Journal ArticleCategory SHORT COMMUNICATIONDOI 10.1007/s10557-009-6176-5Authors R. Ferrera, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 FranceS. Benhabbouche, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 FranceJ. C. Bopassa, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 FranceB. Li, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 FranceM. Ovize, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 France Journal Cardiovascular Drugs and TherapyOnline ISSN... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2433651 Sun, 24 May 2009 05:57:10 +0100 2433651 http://www.medworm.com/index.php?rid=2418102&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx435836713060l04%2F Content Type Journal ArticleDOI 10.1007/s10557-009-6174-7Authors Savina Nodari, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyMarco Metra, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyGiuseppe Milesi, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyAlessandra Manerba, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyBr... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2418102 Thu, 14 May 2009 06:57:03 +0100 2418102 http://www.medworm.com/index.php?rid=2418103&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft073x1j84k1ug20n%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6171-xAuthors Michael H. Davidson, The University of Chicago Pritzker School of Medicine Preventive Cardiology Chicago IL USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2418103 Tue, 12 May 2009 06:05:27 +0100 2418103 http://www.medworm.com/index.php?rid=2399745&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy52700672464354g%2F Content Type Journal ArticleCategory ObituaryDOI 10.1007/s10557-009-6173-8Authors Inder Anand, VA Medical Center 111C University of Minnesota Medical School, Heart Failure Program Minneapolis MN 55417 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2399745 Thu, 07 May 2009 06:02:10 +0100 2399745 http://www.medworm.com/index.php?rid=2370591&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F758261124652v6q2%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10557-009-6172-9Authors Hester M. Den Ruijter, University of Amsterdam Experimental Cardiology Group, Heart Failure Research Center Amsterdam The NetherlandsRuben Coronel, University of Amsterdam Experimental Cardiology Group, Heart Failure Research Center Amsterdam The Netherlands Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2370591 Sat, 25 Apr 2009 07:18:04 +0100 2370591 http://www.medworm.com/index.php?rid=2332055&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F37v6049152330261%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6169-4Authors Ronald M. Witteles, Stanford University School of Medicine Division of Cardiovascular Medicine 300 Pasteur Dr., Falk Cardiovascular Research Center #273 Stanford CA 94305-5406 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2332055 Wed, 08 Apr 2009 08:22:59 +0100 2332055 http://www.medworm.com/index.php?rid=2305785&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu52g74543613j811%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6170-yAuthors Gudrun Antoons, University of Leuven Division Experimental Cardiology, Department of Cardiovascular Medicine Leuven BelgiumKarin R. Sipido, University of Leuven Division Experimental Cardiology, Department of Cardiovascular Medicine Leuven Belgium Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2305785 Thu, 02 Apr 2009 05:59:41 +0100 2305785 http://www.medworm.com/index.php?rid=2239110&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5271lg8t60666qjj%2F Content Type Journal ArticleDOI 10.1007/s10557-009-6166-7Authors Jay N. Cohn, ISCP University of Minnesota Medical School Minneapolis MN 55455 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2239110 Tue, 03 Mar 2009 10:12:54 +0100 2239110 http://www.medworm.com/index.php?rid=2239111&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv35k703644740578%2F Conclusion  Remote postconditioning consisted of 1 min isc/1 min rep protects the ischemic rabbit heart in vivo, independently of the site of the remote artery. This intervention seems to confer a stronger protection than the classic postconditioning. Content Type Journal ArticleDOI 10.1007/s10557-009-6168-5Authors G. Gritsopoulos, University of Athens Medical School, Attikon University Hospital, Athens Second Department of Cardiology 182 Kallergi St 18544 Piraeus GreeceE. K. Iliodromitis, University of Athens Medical School, Attikon University Hospital, Athens Second Department of Cardiology 182 Kallergi St 18544 Piraeus GreeceA. Zoga, University of Athens Medical School, Attikon University Hospital, Athens Second Department of Cardiology 182 Kallergi St 1854... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2239111 Tue, 03 Mar 2009 10:12:53 +0100 2239111 http://www.medworm.com/index.php?rid=2231500&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr8422684g48466wn%2F Conclusion  Extreme caution is required when using nesiritide in patients with both heart failure and concurrent morbidities such as renal dysfunction. Content Type Journal ArticleDOI 10.1007/s10557-009-6167-6Authors Ioannis D. Dontas, University of Athens, Medical School Department of Experimental Surgery and Surgical Research “N.S.Christeas” 15B Agiou Thoma Street 11527 Athens GreeceTheodoros Xanthos, University of Athens, Medical School Department of Experimental Surgery and Surgical Research “N.S.Christeas” 15B Agiou Thoma Street 11527 Athens GreeceIsmene Dontas, University of Athens, Medical School Department of Experimental Surgery and Surgical Research “N.S.Christeas” 15B Agiou Thoma Street 11527 Athens GreecePavlos Lelovas, University of Athens, Medi... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2231500 Sat, 28 Feb 2009 15:13:25 +0100 2231500 http://www.medworm.com/index.php?rid=2487422&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwq25420m77q8t010%2F Conclusion  These results provide evidence that NO-1886 up-regulates expression of NPC1 through LXR α pathway in THP-1 macrophage- derived foam cells. Content Type Journal ArticleDOI 10.1007/s10557-009-6165-8Authors Xin Ma, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaYan-Wei Hu, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaZhong-Cheng Mo, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaXia... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2487422 Fri, 20 Feb 2009 07:10:11 +0100 2487422 http://www.medworm.com/index.php?rid=2204304&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwq25420m77q8t010%2F Conclusion  These results provide evidence that NO-1886 up-regulates expression of NPC1 through LXR α pathway in THP-1 macrophage- derived foam cells. Content Type Journal ArticleDOI 10.1007/s10557-009-6165-8Authors Xin Ma, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaYan-Wei Hu, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaZhong-Cheng Mo, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaXia... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2204304 Fri, 20 Feb 2009 07:10:11 +0100 2204304 http://www.medworm.com/index.php?rid=2487423&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1p2548hm6310g02%2F Conclusion  We hypothesize that ivabradine therapy, when started immediately after hospital admission for ACS, will result in the reduction of hs-CRP levels and the improvement of cardiovascular outcome. Content Type Journal ArticleDOI 10.1007/s10557-009-6164-9Authors Alberto Dominguez-Rodriguez, University Hospital of Canarias Department of Cardiology Tenerife SpainSima Samimi Fard, University Hospital of Canarias Department of Cardiology Tenerife SpainPedro Abreu-Gonzalez, University of La Laguna Department of Physiology Tenerife SpainFrancisco Bosa-Ojeda, University Hospital of Canarias Department of Cardiology Tenerife SpainLuciano Consuegra-Sanchez, Hospital Universitario del Rosell Department of Cardiology Murcia SpainAlejandro Jiménez-Sosa, University Hospital o... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2487423 Fri, 20 Feb 2009 07:10:09 +0100 2487423 http://www.medworm.com/index.php?rid=2204305&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1p2548hm6310g02%2F Conclusion  We hypothesize that ivabradine therapy, when started immediately after hospital admission for ACS, will result in the reduction of hs-CRP levels and the improvement of cardiovascular outcome. Content Type Journal ArticleDOI 10.1007/s10557-009-6164-9Authors Alberto Dominguez-Rodriguez, University Hospital of Canarias Department of Cardiology Tenerife SpainSima Samimi Fard, University Hospital of Canarias Department of Cardiology Tenerife SpainPedro Abreu-Gonzalez, University of La Laguna Department of Physiology Tenerife SpainFrancisco Bosa-Ojeda, University Hospital of Canarias Department of Cardiology Tenerife SpainLuciano Consuegra-Sanchez, Hospital Universitario del Rosell Department of Cardiology Murcia SpainAlejandro Jiménez-Sosa, University Hospital o... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2204305 Fri, 20 Feb 2009 07:10:09 +0100 2204305 http://www.medworm.com/index.php?rid=2199470&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff24076256q137240%2F Conclusions  We conclude that DOF enhanced contractility of rat ventricular myocytes. The enhancement of NCE may be involved in the positive inotropic action of DOF. Content Type Journal ArticleDOI 10.1007/s10557-009-6163-xAuthors Xuan-Ping Zhang, Shanxi Medical University Department of Pharmacology No.56 Xinjian Nanlu Taiyuan Shanxi 030001 People’s Republic of ChinaBo-Wei Wu, Shanxi Medical University Department of Physiology Taiyuan Shanxi 030001 People’s Republic of ChinaCai-Hong Yang, Shanxi Medical University Department of Pharmacology No.56 Xinjian Nanlu Taiyuan Shanxi 030001 People’s Republic of ChinaJie Wang, Shanxi Medical University Department of Pharmacology No.56 Xinjian Nanlu Taiyuan Shanxi 030001 People’s Republic of ChinaShuan-Cheng Niu, Shanxi Me... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2199470 Tue, 17 Feb 2009 13:01:33 +0100 2199470 http://www.medworm.com/index.php?rid=2190319&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6r4m350672pu4685%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6161-4Authors Peter W. de Leeuw, University Hospital Maastricht Department of Medicine P.O. Box 5800 6202 AZ Maastricht The NetherlandsAalt Bast, University of Maastricht Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM) P.O. Box 616 6200 MD Maastricht The Netherlands Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2190319 Sat, 14 Feb 2009 07:54:07 +0100 2190319 http://www.medworm.com/index.php?rid=2152478&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8lu888r76337514%2F Content Type Journal ArticleDOI 10.1007/BF03029737 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 5 Journal Issue Volume 5, Number 3 / June, 1991 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152478 Sat, 31 Jan 2009 06:56:05 +0100 2152478 http://www.medworm.com/index.php?rid=2152480&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F687h3573m40350q0%2F Summary  The main aim of this study was to investigate whether a new slow-release formulation of nicardipine can control hypertension and whether its antihypertensive effect is manifest throughout the dose intervals. In a randomized, double-blind placebo-controlled study, the antihypertensive effect of two calcium antagonists (Type II) was investigated in two independent groups of hypertensive patients with coronary artery disease. One group of patients received 40 mg nicardipine slow-release b.i.d. and the other 20 mg nifedipine slow-release b.i.d. The effect of the active drugs on blood pressure (BP), heart rate, and hemodynamics was compared with placebo within each group. In addition, a group comparison was made to establish whether nicardipine had any advantage over ni... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152480 Sat, 31 Jan 2009 06:56:04 +0100 2152480 http://www.medworm.com/index.php?rid=2152479&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0ww4x7477531n3j%2F Summary  It has been reported that isolated rat heart myocytes and cardiac mesenchymal cells convert arachidonic acid mainly into three types of prostaglandins (PGs): PGE2, PGF2α, and PGI2 [1]. In addition, we have demonstrated that fresh atrial slices of patients with heart-valve disease contain appreciable quantities of PGE2 and PGF2α [2]. However, there have been no reports on the subcellular localization of the prostaglandin system in heart muscle tissue. The present study was performed to define the distribution of PGE2 in mitochondrial, microsomal, and cytosolic fractions, isolated by differential centrifugation from homogenates of fresh normal rat atrium and ventricle slices. In addition, we determined whether differences exist in PGE2 levels between atrial subcellul... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152479 Sat, 31 Jan 2009 06:56:04 +0100 2152479 http://www.medworm.com/index.php?rid=2152482&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm842240h34423646%2F Summary  Hemodynamic effects and inhibitory effects on the pressor response to exogenous angiotensin I of benazepril (CGS 14824A), a new angiotensin-converting enzyme (ACE) inhibitor, were examined in conscious chronically instrumented normotensive dogs in comparison with those of captorpil. Oral administration of benazepril (1–10 mg/kg) and captopril (3 and 10 mg/kg) reduced the blood pressure and inhibited the pressor response to angiotensin I dose-dependently. The blood-pressure-lowering effect of benazepril was as potent as that of captopril. The onset of effects of benazepril was slower and the duration longer than that of captopril. There was no close correlation between the attenuation of pressor response to exogenous angiotensin I and the blood-pressure-lowering e... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152482 Sat, 31 Jan 2009 06:56:03 +0100 2152482 http://www.medworm.com/index.php?rid=2152481&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw723223664054240%2F Content Type Journal ArticleDOI 10.1007/BF03029736Authors Lionel H. Opie Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 5 Journal Issue Volume 5, Number 3 / June, 1991 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152481 Sat, 31 Jan 2009 06:56:03 +0100 2152481 http://www.medworm.com/index.php?rid=2152483&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F518995n222n644gt%2F Summary  A considerable amount of data suggest the involvement of calcium-mediated processes in the activation of the renin-angiotensin-aldosterone (RAA) cascade. To investigate the effect of calcium-channel inhibition on the RAA system, we studied 21 conscious pigs. Blood renin and aldosterone levels increased by subjecting animals to 24 hours of immobilization stress. Renin and aldosterone levels were repeatedly measured by radio-immunoassay in blood samples taken periodically over 24 hours from a chronically implanted arterial cannula. Pretreatment of the animals (N = 11) with nisoldipine, 2 × 20 mg p.o. daily for 2 days before and on the day of immobilization, transiently attenuated the stress-induced increase of plasma renin activity and completely prevented the rise ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152483 Sat, 31 Jan 2009 06:56:02 +0100 2152483 http://www.medworm.com/index.php?rid=2152484&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc43401780111007v%2F Summary  Bisoprolol is a new cardioselective beta1 adrenergic blocking agent without intrinsic sympathomimetic activity but with minimal effects on myocardial contractility. Bisoprolol was compared to propranolol in 24 patients after cardiac surgery for coronary artery bypass graft (CABG). Each patient had been treated preoperatively with beta-blocking agents and had a cineangiographic left ventricular ejection fraction between 35% and 55%. Patients were randomized to receive orally either 10 mg of propranolol three times a day or 5 mg of bisoprolol once a day. Both drugs resulted in a significant and similar decrease in heart rate. This was associated with significant decreases in cardiac index, stroke index, and thermodilution right ventricular ejection fraction 6 hours af... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152484 Sat, 31 Jan 2009 06:56:00 +0100 2152484 http://www.medworm.com/index.php?rid=2152486&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft72316n20x5r6v47%2F Summary  The regulation of vascular resistance, cardiac out-put, and thus blood pressure can be influenced by antihypertensive drugs acting at central and peripheral adrenergic receptors. The results presented here are from acute or chronic studies in 205 patients with mild or moderately severe essential hypertension: beta blockers (N = 101); alpha blockers (N = 36); a separate alpha- + beta-blocker combination or the combination agent labetalol (N = 37); prizidilol, a beta-blocker/vasodilator (N = 14); and dilevalol, a beta blocker/ beta2-stimulator (N = 17). Beta blockers without strong intrinsic sympathomimetic activity reduce heart rate and cardiac output immediately, but due to a reflex increase in total peripheral resistance index, blood pressure is unchanged or only s... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152486 Sat, 31 Jan 2009 06:55:59 +0100 2152486 http://www.medworm.com/index.php?rid=2152485&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk24511x600542733%2F Summary  The pharmacologic treatment of atrial fibrillation (AF) is aimed at controlling the ventricular response, restoring sinus rhythm, and preventing or delaying relapses. In the control of ventricular response, digitalis maintains a primary role when the arrhythmia is accompanied by heart failure. In ischemic, hypertensive, and degenerative (whose number is increasing at present) cardiopathies without evident ventricular dilatation, treatments with calcium antagonists (such as verapamil, gallopamil, or diltiazem) or beta-blocking agents must be preferred. In order to control the ventricular response in patients with chronic AF during physical activity, the association of digitalis with beta-blocking agents or calcium antagonists seems to provide satisfactory results. T... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152485 Sat, 31 Jan 2009 06:55:59 +0100 2152485 http://www.medworm.com/index.php?rid=2152488&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa051320617pw4848%2F Summary  Despite the fact that beta blockers were introduced into clinical practice 25 years ago, new beta blockers with differing kinetic and dynamic profiles continue to be developed and marketed. This overview assesses some of the more extensively studied agents from the point of view of proof of utility and the validity of claims for therapeutic advances. The clinical data suggests that despite the expectations of improvements based on kinetic and dynamic consideration, none of the newer agents have been shownunequivocally, either in terms of efficiency or tolerability, to be an advance over the reference agents, the beta1 antagonists atenolol and metroprolol. This may be either because such improvements will not occur or because of shortcomings in the design and duratio... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152488 Sat, 31 Jan 2009 06:55:58 +0100 2152488 http://www.medworm.com/index.php?rid=2152487&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft574l484347256j3%2F Summary  The use of beta-receptor antagonists in the treatment of heart failure is controversial. Available data do not allow general recommendations regarding their use. In dilated cardiomyopathy, several studies suggest that long-term treatment in individual patients reduces symptoms and increases exercise capacity. Short-term treatment is usually not beneficial, except in patients with ischemically induced left ventricular dysfunction. In heart failure, post myocardial infarction and in chronic ischemic heart disease, no proper long-term study has been performed to evaluate its effects. However, patients with acute myocardial infarction tolerate beta blockers, despite the presence of left ventricular dysfunction and long-term prognosis is improved. Newer agents, some wit... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152487 Sat, 31 Jan 2009 06:55:58 +0100 2152487 http://www.medworm.com/index.php?rid=2152489&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2584k28v46nu7n15%2F Summary  Beta-adrenoceptor blocking agents are established as one of the principal classes of antihypertensive agents. Despite progressive refinements over the years, they still possess some unwanted effects, which limit their considerable value. In recent years a wide range of variations upon the beta-blocker theme has been developed. The full clinical advantages of the newer agents remain to be defined. Content Type Journal ArticleCategory Focused Subsection on New Developments in Beta-BlockadeDOI 10.1007/BF03029727Authors D. McAreavey, Royal Infirmary Department of Cardiology EH3 9YW Edinburgh UKR. Vermeulen, Janssen Research Foundation Beerse BelgiumJ. I. S. Robertson, Chinese University of Hong Kong Department of Medicine, Prince of Wales Hospital China Journa... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152489 Sat, 31 Jan 2009 06:55:57 +0100 2152489 http://www.medworm.com/index.php?rid=2152491&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1547200148v3t712%2F Summary  Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta1-adrenoceptors (β1AR) and beta2-adrenoceptors (β2 AR). Several ionic currents (I) can flow upon βAR activation: ICa (through either β1AR or β2AR), INa, IK, and ICl. Calcium currents (ICa) can be increased directly by the α3, unit of a GTP binding protein, Gs, or by coupling of Gs to adenylyl cyclase with subsequent formation of cyclic AMP, release of the catalytic unit of cyclic AMP-dependent protein kinase, and phosphorylation of calcium channels and other proteins. Chronic exposure (days or months), but not acute exposure (hours), to a catecholamine downregulates human heart β1AR. Acute desensitization partially uncouples human heart βAR from the adenyl... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152491 Sat, 31 Jan 2009 06:55:56 +0100 2152491 http://www.medworm.com/index.php?rid=2152490&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F900132212v41700v%2F Content Type Journal ArticleCategory Focused Subsection on New Developments in Beta-BlockadeDOI 10.1007/BF03029724Authors J. D. Fitzgerald, Materia Medica, Mere Croft Chester Road, Mere, Near Knutsford 16 6LG Cheshire WA UK Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 5 Journal Issue Volume 5, Number 3 / June, 1991 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152490 Sat, 31 Jan 2009 06:55:56 +0100 2152490 http://www.medworm.com/index.php?rid=2152492&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8041810605601t66%2F Content Type Journal ArticleDOI 10.1007/BF03029755 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 5 Journal Issue Volume 5, Number 4 / September, 1991 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152492 Sat, 31 Jan 2009 06:55:54 +0100 2152492 http://www.medworm.com/index.php?rid=2152493&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0455m873m3773655%2F Summary  In a multicenter, parallel, double-blind study, lisinopril, a new converting enzyme inhibitor, was compared with atenolol in the treatment of mild to moderate essential hypertension. Four hundred ninety patients were randomized to once-a-day treatment with lisinopril 20 mg or atenolol 50 mg for 4 weeks, and the doses of lisinopril or atenolol were increased at 4-week intervals up to 80 mg or 200 mg, respectively, if sitting diastolic blood pressure (SDBP) was not well controlled. Lisinopril and atenolol reduced SDBP to a similar extent. All reductions from baseline in sitting diastolic and systolic blood pressure were significant (p < 0.01). Lisinopril produced a significantly greater reduction (p < 0.01) in sitting systolic blood pressure (SSBP) than atenolo... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152493 Sat, 31 Jan 2009 06:55:53 +0100 2152493 http://www.medworm.com/index.php?rid=2152495&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn375443r78pl8881%2F Summary  The possibility that a magnesium deficiency might be the underlying cause of vasospastic angina (VA) and the efficacy of Mg administration in its treatment were studied. Subjects included 15 patients with VA and 18 healthy subjects as the control group. The erythrocyte Mg content was measured by atomic absorption, and serum Mg was measured by conventional chemical assay. The efficacy of Mg administration was studied in seven patients with VA. The results were as follows: a) The mean erythrocyte Mg content was less in the group with frequent episodes of angina (1.59 ± 0.11 mg/ dl) than in the group without angina (2.11 ± 0.38 mg/dl, p < 0.01) and in the control group (2.22 ± 0.29 mg/dl, p < 0.01). There was no significant difference between the control grou... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152495 Sat, 31 Jan 2009 06:55:52 +0100 2152495 http://www.medworm.com/index.php?rid=2152494&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff1356440m341vx3p%2F Summary  The purpose of this study has been to compare the acute antihypertensive effect of a dose of 20 mg of ketanserin in 18 patients after sublingual administration and in 19 after oral administration. In three patients ketanserin and ketanserin-ol plasma levels were measured after both sublingual and oral administration. The results showed a more rapid, considerable antihypertensive effect after sublingual administration. In addition, the high plasma levels of ketanserin-ol, the metabolite produced by hepatic reduction of ketanserin, reached after sublingual administration, rather than transmucosal absorption, indicate that the clinical effect observed is due to more rapid dissolution of the tablet formulation and liberation of the active drug. Content Type Journal A... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152494 Sat, 31 Jan 2009 06:55:52 +0100 2152494 http://www.medworm.com/index.php?rid=2152497&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw736713835vv8142%2F Summary  Twelve patients with mild to moderate essential hypertension were included in a double-blind, balanced, randomized placebo-controlled cross-over study to assess the efficacy and duration of action of a new slow-release formulation of diltiazem (300 mg) given once daily for 3 weeks. All office blood pressure measurements were done 24 hours after drug intake. In order to improve the accuracy of the trial, 24-hours non-invasive ambulatory blood pressure monitoring (Spacelabs 90207 system) were performed as well. Diltiazem significantly lowered supine and standing systolic and diastolic office blood pressure (by 16.9/12.7 mmHg and by 17.3/ 13.8 mmHg, respectively), without changing office heart rate. Diltiazem also significantly lowered ambulatory blood pressure measur... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152497 Sat, 31 Jan 2009 06:55:51 +0100 2152497 http://www.medworm.com/index.php?rid=2152496&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6576768863w21355%2F Summary  The hemodynamic and antiischemic effects of a 150-mg single oral dose of the PDE inhibitor enoximone were correlated with the plasma levels of enoximone and its sulfoxide metabolite. Twenty-one patients with angiographically documented coronary artery disease were investigated by exercise testing 1 and 2 hours after drug administration. The control group consisted of 15 patients with proven coronary artery disease and stable reproducible angina pectoris on exercise. The enoximone group included 14 responders with therapeutic plasma concentrations 2 hours after drug intake and significantly reduced mean pulmonary artery pressures on exercise (from 42.4 ± 8.6 to 30.9 ± 11.2 mmHg, p < 0.05). Compared to basal exercise values, responders showed a reduced ST-segmen... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2152496 Sat, 31 Jan 2009 06:55:51 +0100 2152496 http://www.medworm.com/index.php?rid=2149325&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv7r5v47660465575%2F Conclusions  Our study shows, that the agreement for the available Swiss guidelines (IAS-AGLA, ESC score) for initiation of a lipid lowering therapy is low in our primary prevention group of subjects aged 45–65 years. According to the PROCAM study, about 30% of myocardial infarctions occur in persons with an intermediate risk. Therefore an improved risk stratification strategy is necessary. Content Type Journal ArticleDOI 10.1007/s10557-009-6162-yAuthors Michel Romanens, Ziegelfeldstrasse 1 4600 Olten SwitzerlandFranz Ackermann, 4600 Olten SwitzerlandMichael Abay, 8001 Zurich SwitzerlandThomas Szucs, University of Zurich Institute of Social- and Preventive Medicine Zurich SwitzerlandMatthias Schwenkglenks, c/o ECPM Executive Office ECPM Research 4031 Basel Switz... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2149325 Fri, 30 Jan 2009 06:50:30 +0100 2149325 http://www.medworm.com/index.php?rid=2128300&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc4q1624744587467%2F Conclusions  Overall, the FIELD study data support the use of fenofibrate for CVD prevention in diabetes, ideally in patients without prior macrovascular or microvascular complications. Fenofibrate may also have a role as a preventive treatment for diabetic retinopathy. Addition of fenofibrate to statin therapy may a logical progression from the FIELD study data, although the efficacy and tolerability of this approach needs to be evaluated in prospective outcome studies. Content Type Journal ArticleCategory ReviewDOI 10.1007/s10557-008-6160-5Authors Sergio Fazio, Vanderbilt University School of Medicine Division of Cardiovascular Medicine Nashville TN USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular D... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2128300 Thu, 22 Jan 2009 11:31:42 +0100 2128300 http://www.medworm.com/index.php?rid=2120578&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh3125570q507762g%2F Content Type Journal ArticleDOI 10.1007/s10557-008-6148-1Authors Robert S. Rosenson, University of Michigan Division of Cardiovascular Medicine Ann Arbor MI USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 23 Journal Issue Volume 23, Number 1 / February, 2009 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120578 Tue, 20 Jan 2009 10:39:27 +0100 2120578 http://www.medworm.com/index.php?rid=2120581&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa6xm7224070v655n%2F Content Type Journal ArticleCategory Book ReviewsDOI 10.1007/BF00051137 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 10 Journal Issue Volume 10, Number 1 / March, 1996 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120581 Mon, 19 Jan 2009 08:19:56 +0100 2120581 http://www.medworm.com/index.php?rid=2120580&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft3680j2052321836%2F Content Type Journal ArticleCategory Book ReviewsDOI 10.1007/BF00051135 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 10 Journal Issue Volume 10, Number 1 / March, 1996 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120580 Mon, 19 Jan 2009 08:19:56 +0100 2120580 http://www.medworm.com/index.php?rid=2120579&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb31w58345785u054%2F Content Type Journal ArticleCategory Book ReviewsDOI 10.1007/BF00051138 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 10 Journal Issue Volume 10, Number 1 / March, 1996 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120579 Mon, 19 Jan 2009 08:19:56 +0100 2120579 http://www.medworm.com/index.php?rid=2120585&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq88jh1535035x400%2F This study assessed the usefulness of the oral captopril test in the prediction of renal impairment among elderly patients with congestive heart failure (CHF). Fortyseven patients aged ≥65 years with CHF (EF <40%) participated in a prospective nonrandomized series. Blood samples for plasma renin activity (PRA) were drawn before and 60 minutes after 50 mg of oral captopril. Twenty-four hours later, captopril was administered (up to 75 mg/day over a 4 day period), and renal laboratory and clinical assessment were performed at baseline and for a 9 day period. In 7 of 47 patients (14.9%), deterioration of renal function was observed. During the captopril test, the PRA increased significantly after 1 hour in almost all patients and the mean blood pressure decreased from 99.2±14.6 mm... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120585 Mon, 19 Jan 2009 08:19:55 +0100 2120585 http://www.medworm.com/index.php?rid=2120584&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq008h25r415n6478%2F In conclusion, pranidipine is a well-tolerated and 24-hour effective novel calcium antagonist that reduces BP in a dose-related manner up to 4 mg od. Content Type Journal ArticleCategory HypertensionDOI 10.1007/BF00051131Authors Julian Rosenthal, Ulm University Medical Center Ulm GermanyNorbert Hittel, Ulm University Medical Center Ulm GermanyKarl Otto Stumpe, University Medical Center Bonn Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 10 Journal Issue Volume 10, Number 1 / March, 1996 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120584 Mon, 19 Jan 2009 08:19:55 +0100 2120584 http://www.medworm.com/index.php?rid=2120583&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhh1057150696480t%2F Summary  Tilisolol is a beta-blocking agent with vasodilatory properties that was recently shown to possess a potassium (K+) channel opening activity. We investigated whether tilisolol has vasodilatory effects on coronary circulation in dogs. Mongrel dogs were chronically instrumented for measurements of circumflex coronary artery diameter (CoD) and coronary blood flow (CBF). We compared the effects of tilisolol on dog coronary arteries with those of two beta-blockers, propranolol and arotinolol. Both propranolol (1 mg/kg, intravenously, IV) and arotinolol (0.25 mg/kg, IV) decreased CoD and increased coronary vascular resistance (CVR). Tilisolol (2 mg/kg, IV) decreased CVR but had no significant effect on CoD. To investigate the mechanism of the coronary action of tilisolol,... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120583 Mon, 19 Jan 2009 08:19:55 +0100 2120583 http://www.medworm.com/index.php?rid=2120582&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr292g368825t6633%2F Summary  The purpose of this study was to examine the effects of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on the elastic properties of the aorta. A standard diuretic antihypertensive drug, hydrochlorothiazide, served for comparisons. Increased aortic stiffness leads to a reduction of the buffering windkessel function and is a major component in the pathophysiology of systolic hypertension, inducing an increase in left ventricular afterload and arterial pulsatile stress as well as a decrease in the subendocardial blood supply. Stiffness of arteries increases with age and blood pressure, and depends on the functional elastic structures of the aortic wall. ACE inhibitors have been shown to directly influence elastic properties of peripheral arteries. Sevent... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120582 Mon, 19 Jan 2009 08:19:55 +0100 2120582 http://www.medworm.com/index.php?rid=2120586&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg85048876g773437%2F Summary  Arbutamine, developed for use as a cardiac stress agent, was compared with isoproterenol and dobutamine in anesthetized dogs for cardiovascular actions prior to and after beta-adrenergic blockade with propranolol. The efficacy and safety of arbutamine were also evaluated in a canine model of myocardial ischemia obtained by partially occluding the left anterior descending coronary artery. Comparison of hemodynamic variables in normal dogs showed that arbutamine was approximately equipotent to isoproterenol in increasing heart rate and cardiac contractility, and in decreasing total peripheral vascular resistance and mean arterial blood pressure. Arbutamine was 210 times more potent than dobutamine in increasing cardiac contractility by 70%; however, at this dose dobu... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120586 Mon, 19 Jan 2009 08:19:54 +0100 2120586 http://www.medworm.com/index.php?rid=2120587&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy13053275x753367%2F Summary  Chronic treatment with cyclosporine A (Cx) seems to produce a decreased ability of the endothelium to secrete nitric oxide. However, its effect on the coronary arterial system remains controversial. Therefore, coronary arteries isolated from piglets treated by intramuscular injections of Cx 10 mg/kg day, IM, for 22 days were studied in organ baths and compared with those isolated from control animals (IM injections of the Cx solvent). Depolarization-induced contractions (KCl 120 mM) were similar in both groups, whereas the acetylcholine-induced contractions (percent of 120 mM KCl) were enhanced: The area under the curve (AUC) was 245±51 in the Cx group versus 110±15 in the control group (p<0.05). Removal of the endothelium did not significantly modify the acet... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120587 Mon, 19 Jan 2009 08:19:50 +0100 2120587 http://www.medworm.com/index.php?rid=2120588&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe4034585v2r47265%2F Summary  Acute management of supraventricular tachyarrhythmias is often difficult in elderly patients. Diltiazem was given intravenously (loading dose of 0.25 mg/kg over 2 minutes followed by a 4 mg/kg/24 hr infusion) in 37 elderly patients (mean age 70 years, range 60–91). Fifteen out of the 37 patients (41%) had left ventricular cardiac disease, 12 (32%) had cor pulmonale, and 10 (27%) had no obvious cardiac disease. Hemodynamic tolerance of the supraventricular tachyarrhythmia was poor in 12 patients. A good result was defined as a return to sinus rhythm after bolus or infusion, or as a slowing of the ventricular rate (VR) to less than 100 beats/min. Of the 23 patients in atrial fibrillation, about half reverted to sinus rhythm after diltiazem, and in most of the other... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120588 Mon, 19 Jan 2009 08:19:47 +0100 2120588 http://www.medworm.com/index.php?rid=2120590&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw113v2m7544t8674%2F Summary  After a decade of controversy and debate, many experts have now concluded that continous nitroglycerin patch treatment leads to complete tolerance development and therefore cannot be recommended for any angina patient. This conclusion is largely based on the disappointing results of the large Transdermal Nitroglycerin Cooperative Study, in which continuous patch treatment in doses of 15–105 mg daily failed to increase exercise duration more than placebo after 2 and 8 weeks of treatment. However, other well-designed studies recently reported maintained efficacy during continuous treatment, and the differences in results has remained unexplained. The disagreeing data may be better understood if certain facts are considered: (1) The cooperative study tested a patien... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120590 Mon, 19 Jan 2009 08:19:43 +0100 2120590 http://www.medworm.com/index.php?rid=2120589&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw7m87k5510483750%2F In conclusion, arbutamine is a novel catecholamine with similar potency and efficacy to that of isoproterenol. It stimulates cardiac beta1-, tracheal beta2-, and adiopocyte beta3-adrenergic receptors. Arbutamine does not stimulate alpha-adrenergic receptors at concentrations that wer high enough to maximally activate the beta-adrenergic receptors. Content Type Journal ArticleCategory Experimental PharmacologyDOI 10.1007/BF00051129Authors Gamal Abou-Mohamed, Medical College of Georgia Department of Pharmacology and Toxicology Augusta GeorgiaRavi Nagarajan, Medical College of Georgia Department of Pharmacology and Toxicology Augusta GeorgiaTarek M. Ibrahim, Mansoura University Mansoura School of Pharmacy EgyptRobert W. Caldwell, Medical College of Georgia Department of Pharmacology an... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120589 Mon, 19 Jan 2009 08:19:43 +0100 2120589 http://www.medworm.com/index.php?rid=2120591&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmg60100758263505%2F Summary  Previous reports, based on clinical trials and animal experiments, suggest that beta-blockers may be useful in the prevention of atherosclerosis. Betaxolol, a new beta1-selective blocker, was shown to decrease plasma total and LDL cholesterol levels or to have no adverse effect on those [1–4]. While many reports deal with the metabolism of triglyceride and high density lipoprotein, fewer publications about cholesterol metabolism are currently available. To clarify the mechanism by which beta-blockers affect lipid metabolism, we examined the effects of beta-blockers on HMG CoA reductase and LDL receptor activity in cultured human skin fibroblasts. L-propranolol, a nonselective betablocker, increased HMG CoA reductase activity and decreased LDL receptor activity. Ho... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120591 Mon, 19 Jan 2009 08:19:40 +0100 2120591 http://www.medworm.com/index.php?rid=2120592&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5745721k6t106h4m%2F Summary  Patients with heart failure generally show improvement in their clinical condition after enoximone infusion over the period of treatment; this effect cannot be ascribed only to the known hemodynamic action of this drug. Thirty-six patients (age range 44–82 years) with heart failure (NYHA class II–IV) underwent 48-hour enoximone infusion to study whether this prolonged improvement might depend on changes in systemic or renal hemodynamics or in neurohormonal balance. All patients underwent Swan-Ganz hemodynamic monitoring; renal plasma flow, glomerular filtration rate, plasma atrial natriuretic factor (ANF), and plasma renin activity (PRA) were all measured at baseline, at the peak of the enoximone action, and 48 hours after drug discontinuation. The main hemodyn... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120592 Mon, 19 Jan 2009 08:19:37 +0100 2120592 http://www.medworm.com/index.php?rid=2120593&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv1w73g1120348081%2F Content Type Journal ArticleCategory Book ReviewsDOI 10.1007/BF00051136 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 10 Journal Issue Volume 10, Number 1 / March, 1996 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120593 Mon, 19 Jan 2009 08:19:34 +0100 2120593 http://www.medworm.com/index.php?rid=2120594&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flg1v101m857j79j7%2F Content Type Journal ArticleDOI 10.1007/BF00051139 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 10 Journal Issue Volume 10, Number 1 / March, 1996 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2120594 Mon, 19 Jan 2009 08:19:22 +0100 2120594 http://www.medworm.com/index.php?rid=2086511&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxt57120507341672%2F Conclusions  These data demonstrate that monocytes from HC patients are more prone to marked nLDL-mediated changes of adhesion molecule expression than monocytes from controls. Simvastatin is capable of inhibiting such nLDL effects. This proinflammatory response to nLDL may have a role in the early onset of atherosclerosis. Content Type Journal ArticleDOI 10.1007/s10557-008-6159-yAuthors Carlos V. Serrano, University of São Paulo Heart Institute (InCor) HCFMUSP, Medical School Av. Enéas C. de Aguiar, 44 São Paulo SP 05403-000 BrazilAntônio Eduardo Pesaro, University of São Paulo Heart Institute (InCor) HCFMUSP, Medical School Av. Enéas C. de Aguiar, 44 São Paulo SP 05403-000 BrazilJames A. de Lemos, University of Texas Southwestern Medical Center Dallas TX USAFa... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2086511 Tue, 06 Jan 2009 16:09:10 +0100 2086511 http://www.medworm.com/index.php?rid=2055546&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu7r2mg28hx1rk603%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6158-zAuthors Nuno M. Pires, Leiden University Medical Centre Department of Cardiology PO Box 9600 2300 RC Leiden The NetherlandsJ. Wouter Jukema, Leiden University Medical Centre Department of Cardiology PO Box 9600 2300 RC Leiden The Netherlands Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2055546 Fri, 19 Dec 2008 08:23:49 +0100 2055546 http://www.medworm.com/index.php?rid=2032469&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc3274l46guu834u8%2F Conclusion  The PERGENE study is a large cardiovascular pharmacogenetic study aimed to assess the feasibility of pharmacogenetic profiling of the treatment effect of ACE-inhibitor use with the perspective to individualize treatment in patients with stable coronary artery disease. Content Type Journal ArticleDOI 10.1007/s10557-008-6156-1Authors J. J. Brugts, Erasmus Medical Center Department of Cardiology Dr. Molewaterplein 40. 3015GD Rotterdam The NetherlandsM. P. M. de Maat, Erasmus MC Department of Haematology Rotterdam The NetherlandsE. Boersma, Erasmus Medical Center Department of Cardiology Dr. Molewaterplein 40. 3015GD Rotterdam The NetherlandsJ. C. M. Witteman, Erasmus MC Department of Epidemiology & Biostatistics Rotterdam The NetherlandsC. van Duijn, Erasmus M... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2032469 Thu, 11 Dec 2008 12:00:06 +0100 2032469 http://www.medworm.com/index.php?rid=2016413&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft6703450577434mm%2F Conclusions  Tomato extract when added to patients treated with low doses of ACE inhibition, calcium channel blockers or their combination with low dose diuretics, had a clinically significant effect—reduction of BP by more than 10 mmHg systolic and more than 5 mmHg diastolic pressure. No side-effects to treatment were recorded and the compliance with treatment was high. The significant correlation between systolic blood pressure values and level of lycopene suggest the possibility of cause–effect relationships. Content Type Journal ArticleDOI 10.1007/s10557-008-6155-2Authors Esther Paran, Ben Gurion University of the Negev Hypertension Unit, Soroka University Hospital, Faculty of Health Sciences Beer Sheba 84101 IsraelVictor Novack, Ben Gurion Universit... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2016413 Thu, 04 Dec 2008 09:07:20 +0100 2016413 http://www.medworm.com/index.php?rid=2016412&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3741050578tpg18p%2F Conclusions  Doxy decreases MMP-9 plasma levels by around 20%, within the first 12 h. The mechanism leading to such reduction seems due to the inhibition of PMN degranulation. Content Type Journal ArticleDOI 10.1007/s10557-008-6150-7Authors Nicola Fiotti, Università degli Studi di Trieste S. C. Clinica Medica Generale e Terapia Medica, Dipartimento di Scienze Cliniche, Morfologiche e Tecnologiche Strada di Fiume, 447 34149 Trieste ItalyNicola Altamura, Università degli Studi di Trieste S. C. Clinica Medica Generale e Terapia Medica, Dipartimento di Scienze Cliniche, Morfologiche e Tecnologiche Strada di Fiume, 447 34149 Trieste ItalyMichèle Moretti, Università degli Studi di Trieste S. C. Clinica Medica Generale e Terapia Medica, Dipartimento di Scienze Clinich... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2016412 Thu, 04 Dec 2008 09:07:20 +0100 2016412 http://www.medworm.com/index.php?rid=2016411&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu528772l1l03k3l1%2F Conclusion  Our data in the atherogenic ApoE−/− mouse demonstrates that the Ang II induced increase in both monocytic CD11b integrin expression and monocyte vascular infiltration occurs early in atherogenesis. These Ang II-induced monocytic changes are in part regulated through the MCP-1/CCR2 interaction. Content Type Journal ArticleDOI 10.1007/s10557-008-6157-0Authors Terry C. Major, Pfizer Global Research and Development Cardiovascular and Atherosclerosis Biology Ann Arbor MI USABronia Olszewski, Pfizer Global Research and Development Cardiovascular and Atherosclerosis Biology Ann Arbor MI USAWendy S. Rosebury-Smith, LLC Cutting Image Histology Ann Arbor MI USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardio... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=2016411 Thu, 04 Dec 2008 09:07:20 +0100 2016411 http://www.medworm.com/index.php?rid=1974367&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F46l2430418826891%2F Content Type Journal ArticleDOI 10.1007/s10557-008-6153-4Authors J. Horowitz, University of Adelaide Adelaide AustraliaW. J. Remme, Sticares Cardiovascular Research Institute P.O. Box 882 3160 AB Rhoon The NetherlandsC. Torp-Pedersen, University of Copenhagen Gentofte Hospital Hellerup Denmark Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1974367 Wed, 19 Nov 2008 19:03:20 +0100 1974367 http://www.medworm.com/index.php?rid=1974368&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk93214w705256426%2F Conclusions  Our findings suggest that a drug-eluting stent implantation could trigger a systemic inflammatory response as previously demonstrated. However, SES implantation results in a lower inflammatory response compared with PES implantation, which seems to be associated with greater late of in-stent and in-segment loss at 8-month follow-up with PES. Content Type Journal ArticleDOI 10.1007/s10557-008-6149-0Authors Jian-Jun Li, Peking Union Medical College Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences Beijing 100037 People’s Republic of ChinaHong-Bing Yan, Capital University of Medical Sciences Department of Cardiology, Beijing Anzhen Hospital Beijing 100029 People’s Republic of ChinaXiao-Ping Xiang, Phoenix Hospital Group Depart... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1974368 Wed, 19 Nov 2008 19:03:19 +0100 1974368 http://www.medworm.com/index.php?rid=1959447&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0jr99m3881400163%2F Conclusion  Anakinra inhibits apoptosis and ameliorates cardiac remodeling up to 4 weeks after infarction. A 2-week regimen is superior to a 1-week regimen, whereas a higher dose did not provide any further benefit over standard doses. Content Type Journal ArticleDOI 10.1007/s10557-008-6154-3Authors Fadi N. Salloum, Virginia Commonwealth University, Medical College of Virginia VCU Pauley Heart Center Richmond VA USAVinh Chau, Virginia Commonwealth University, Medical College of Virginia VCU Pauley Heart Center Richmond VA USAAmit Varma, Virginia Commonwealth University, Medical College of Virginia VCU Pauley Heart Center Richmond VA USANicholas N. Hoke, Virginia Commonwealth University, Medical College of Virginia VCU Pauley Heart Center Richmond VA USAStefano Told... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1959447 Thu, 13 Nov 2008 16:06:09 +0100 1959447 http://www.medworm.com/index.php?rid=1959449&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F70322k31m4ph2175%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6152-5Authors Anil Verma, Ochsner Heart and Vascular Institute New Orleans LA USAHector O. Ventura, Ochsner Heart and Vascular Institute New Orleans LA USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1959449 Thu, 13 Nov 2008 16:06:08 +0100 1959449 http://www.medworm.com/index.php?rid=1959448&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp284nl76517u5347%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6151-6Authors Meritt H. Raitt, Portland VA Medical Center Portland OR USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1959448 Thu, 13 Nov 2008 16:06:08 +0100 1959448 http://www.medworm.com/index.php?rid=1938095&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn724g1m375827520%2F Conclusions  N-3 PUFAs administration is associated with favorable effects on parameters related to arrhythmic risk in patients with idiopathic dilated cardiomyopathy. These results are consistent with antiarrhythmic activity independent from their antiischemic effects. Content Type Journal ArticleDOI 10.1007/s10557-008-6142-7Authors Savina Nodari, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyMarco Metra, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyGiuseppe Milesi, University of Brescia Section of Cardiovascular Diseases, Departmen... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1938095 Tue, 04 Nov 2008 07:18:31 +0100 1938095 http://www.medworm.com/index.php?rid=1911016&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy4540718mg681712%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6145-4Authors Reginald Liew, National Heart Centre Department of Cardiology Singapore Singapore Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1911016 Fri, 24 Oct 2008 06:54:42 +0100 1911016 http://www.medworm.com/index.php?rid=1911019&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F681026h9222h1287%2F Conclusion  This review summarizes the epidemiologic evidence on the association between increased mass or elevated activity of these two phospholipases and risk of CVD. Content Type Journal ArticleDOI 10.1007/s10557-008-6135-6Authors Wolfgang Koenig, University of Ulm Medical Center Department of Internal Medicine II—Cardiology Albert-Einstein Allee, 23 89081 Ulm GermanyNatalie Khuseyinova, University of Ulm Medical Center Department of Internal Medicine II—Cardiology Albert-Einstein Allee, 23 89081 Ulm Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1911019 Fri, 24 Oct 2008 06:54:41 +0100 1911019 http://www.medworm.com/index.php?rid=1911018&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnn6w5w3216362w64%2F Conclusions  This proof of concept trial is the first to suggest that specific inhibition of PKC beta may improve macro vascular endothelial function in type-2 diabetes. Larger trials including clinical endpoints are warranted to determine the potential efficacy of PKC beta inhibition in reducing atherosclerotic cardiovascular complications in diabetes mellitus. Content Type Journal ArticleDOI 10.1007/s10557-008-6144-5Authors Nehal N. Mehta, University of Pennsylvania Medical Center Cardiovascular Institute 909 BRB 2/3, 421 Curie Blvd. Philadelphia PA 19104-6160 USAMatthew Sheetz, Eli Lilly Research Labs Indianapolis IN USAKaren Price, Eli Lilly Research Labs Indianapolis IN USALynn Comiskey, University of Pennsylvania Medical Center Cardiovascular Institute 909 BRB 2/... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1911018 Fri, 24 Oct 2008 06:54:41 +0100 1911018 http://www.medworm.com/index.php?rid=1911017&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F711q43r678884540%2F Abstract  Development of a thrombus at the site of an atherosclerotic plaque initiates abrupt arterial occlusion and is the proximate event responsible for the vast majority of acute ischemic syndromes. In nearly 75% of cases thrombus overlies a disrupted or ruptured plaque whereas the remainder of the thrombi overly an intact plaque with superficial endothelial erosion. Over the past several years, it has been recognized that plaque composition rather than plaque size or stenosis severity is important for plaque rupture and subsequent thrombosis. Ruptured plaques, and by inference, plaques prone to rupture, tend to be large in size with associated expansive arterial remodeling, thin fibrous cap with a thick or large necrotic lipid core with immuno-inflammatory cell infiltr... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1911017 Fri, 24 Oct 2008 06:54:41 +0100 1911017 http://www.medworm.com/index.php?rid=1911022&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl7782345tljh4712%2F This article is focused on platelet-activating factor acetylhydrolase (PAF-AH), a lipoprotein bound, calcium-independent phospholipase A2 activity also referred to as lipoprotein-associated phospholipase A2 or PLA2G7. PAF-AH catalyzes the removal of the acyl group at the sn-2 position of PAF and truncated phospholipids generated in settings of inflammation and oxidant stress. Discussion  Here, I discuss current knowledge related to the structural features of this enzyme, including the molecular basis for association with lipoproteins and susceptibility to oxidative inactivation. The circulating form of PAF-AH is constitutively active and its expression is upregulated by mediators of inflammation at the transcriptional level. This mechanism is likely responsible for the... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1911022 Fri, 24 Oct 2008 06:54:40 +0100 1911022 http://www.medworm.com/index.php?rid=1911021&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd743466242x76gu3%2F Conclusions  These results suggest that pharmacological inhibition of PARP prevents the development of endothelial dysfunction in rats with hyperhomocysteinemia which may represent a novel approach to improve vascular dysfunction associated with hyperhomocysteinemia. Content Type Journal ArticleDOI 10.1007/s10557-008-6146-3Authors Xian Yu, Huazhong University of Science and Technology Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College Wuhan 430022 ChinaXiang Cheng, Huazhong University of Science and Technology Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College Wuhan 430022 ChinaJiang-jiao Xie, Huazhong University of Science and Technology Laboratory of Cardiovascu... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1911021 Fri, 24 Oct 2008 06:54:40 +0100 1911021 http://www.medworm.com/index.php?rid=1911020&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd667213366540841%2F Conclusion  Both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested to induce beneficial effects at different stages of the atherosclerosis process. Content Type Journal ArticleDOI 10.1007/s10557-008-6140-9Authors Magnus Bäck, Bichat Hospital INSERM U698 46 rue Henri Huchard 75018 Paris France Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1911020 Fri, 24 Oct 2008 06:54:40 +0100 1911020 http://www.medworm.com/index.php?rid=1894150&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl55t818673791v15%2F Conclusion  The treatment benefit in EUROPA cannot be fully explained by baseline BP or BP reduction with perindopril. Other mechanisms including direct anti-atherosclerotic effects of ACE inhibition may play a role. Content Type Journal ArticleDOI 10.1007/s10557-008-6143-6Authors Willem J. Remme, Sticares Cardiovascular Research Institute P.O. Box 882 3160 AB Rhoon The NetherlandsJaap W. Deckers, Thoraxcenter, Erasmus Medical Center Rotterdam The NetherlandsKim M. Fox, Royal Brompton Hospital Department of Cardiology London UKRoberto Ferrari, IRCCS, University Hospital of Ferrara Cardiovascular Research Center, Salvatore Maugeri Foundation Gussago Bressia ItalyMichel Bertrand, Hopital Cardiologique Lille FranceMaarten L. Simoons, Thoraxcenter, Erasmus Medical Center Ro... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1894150 Sat, 18 Oct 2008 11:05:45 +0100 1894150 http://www.medworm.com/index.php?rid=1894149&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F55g85ru7554447l8%2F Abstract  The phospholipase A2 (PLA2) superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids. The products of this reaction, a free fatty acid, and lysophospholipid have many different important physiological roles. There are five main types of PLA2: the secreted sPLA2’s, the cytosolic cPLA2’s, the Ca2+independent iPLA2’s, the PAF acetylhydrolases, and the lysosomal PLA2’s. This review focuses on the superfamily of PLA2 enzymes, and then uses three specific examples of these enzymes to examine the differing biochemistry of the three main types of these enzymes. These three examples are the GIA cobra venom PLA2, the GIVA cytosolic cPLA2, and the GVIA Ca2+-independent iPLA2. ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1894149 Sat, 18 Oct 2008 11:05:45 +0100 1894149 http://www.medworm.com/index.php?rid=1879347&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F258458h42g888618%2F Abstract Introduction  The secretory phospholipase A2 (sPLA2) family provides a seemingly endless array of potential biological functions that is only beginning to be appreciated. In humans, this family comprises 9 different members that vary in their tissue distribution, hydrolytic activity, and phospholipid substrate specificity. Through their lipase activity, these enzymes trigger various cell-signaling events to regulate cellular functions, directly kill bacteria, or modulate inflammatory responses. In addition, some sPLA2’s are high affinity ligands for cellular receptors. Objective  This review merely scratches the surface of some of the actions of sPLA2s in innate immunity, inflammation, and atherosclerosis. The goal is to provide an overview of rece... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1879347 Tue, 14 Oct 2008 11:20:47 +0100 1879347 http://www.medworm.com/index.php?rid=1879346&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj6j61428qg09wk06%2F Conclusion  These results suggested that the emerging anti-arrhythmic character induced by resveratrol treatment in rat hearts could be mainly accounted for by inhibition of I Ca-L and enhancement of I K,ATP. Administration of resveratrol also improved the long-term survival by suppressing left ventricular remodeling. Content Type Journal ArticleDOI 10.1007/s10557-008-6141-8Authors You-Ren Chen, Shantou University Department of Cardiology, The Second Affiliated Hospital to Medical College Shantou 515041 People’s Republic of ChinaFang-Fang Yi, Capital Medical University Department of Cardiology, Chaoyang Hospital Beijing 100020 People’s Republic of ChinaXin-Yi Li, Zhongnan Hospital of Wuhan University Department of Anesthesiology Wuhan 430071 People’s Republic of... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1879346 Tue, 14 Oct 2008 11:20:47 +0100 1879346 http://www.medworm.com/index.php?rid=1850391&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc63538488784r210%2F Conclusions  The PEGASE education program improved risk factors for CVD, although global assessment by Framingham score was not significantly different between groups. This program, aimed at meeting needs and expectations of patients and physicians, was easily implemented in all hospital centres. Content Type Journal ArticleDOI 10.1007/s10557-008-6137-4Authors Eric Bruckert, Service d’Endocrinologie-Métabolisme Groupe hospitalier Pitié-Salpétrière 47-83, Boulevard de l’Hôpital 75651 Paris Cedex 13 FrancePhilippe Giral, Service d’Endocrinologie-Métabolisme Groupe hospitalier Pitié-Salpétrière 47-83, Boulevard de l’Hôpital 75651 Paris Cedex 13 FranceFrançois Paillard, CHU Rennes FranceJean Ferrières, CHU Toulouse FranceJean-Louis Schlienger, CHU Stras... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1850391 Thu, 02 Oct 2008 09:30:44 +0100 1850391 http://www.medworm.com/index.php?rid=1844058&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb07n4552159376n7%2F In conclusion, the infarct size limiting effects of PIO are dependent on activation of mitochondrial ATP-sensitive K+ channels. Oral Glyb, but not Glim, blocks the infarct size limiting effects of PIO. It is plausible that Glyb affects other pleiotropic effects of PIO and thus may attenuate favorable effects on cardiovascular outcomes. In contrast, Glim does not attenuate the protective effect of PIO. Content Type Journal ArticleDOI 10.1007/s10557-008-6138-3Authors Yumei Ye, University of Texas Medical Branch The Division of Cardiology 5.106 John Sealy Annex, 301 University Blvd Galveston TX 77555-0553 USAYu Lin, University of Texas Medical Branch The Division of Cardiology 5.106 John Sealy Annex, 301 University Blvd Galveston TX 77555-0553 USAJose R. Perez-Polo, University of ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1844058 Tue, 30 Sep 2008 09:23:43 +0100 1844058 http://www.medworm.com/index.php?rid=1844059&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj384537502873163%2F Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s10557-008-6136-5Authors Hilary K. Siddall, University College London Hospital and Medical School The Hatter Cardiovascular Institute 67 Chenies Mews London WC1E 6HX UKClare E. Warrell, University College London Hospital and Medical School The Hatter Cardiovascular Institute 67 Chenies Mews London WC1E 6HX UKSean M. Davidson, University College London Hospital and Medical School The Hatter Cardiovascular Institute 67 Chenies Mews London WC1E 6HX UKMihaela M. Mocanu, University College London Hospital and Medical School The Hatter Cardiovascular Institute 67 Chenies Mews London WC1E 6HX UKDerek M. Yellon, University College London Hospital and Medical School The Hatter Cardiovascular Institute 67 Chenies Mews London WC1... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1844059 Tue, 30 Sep 2008 09:23:42 +0100 1844059 http://www.medworm.com/index.php?rid=1805738&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7n132115565753n3%2F Conclusions  Atherosclerotic cardiovascular diseases impose a significant economic burden on Belgian society. Content Type Journal ArticleDOI 10.1007/s10557-008-6128-5Authors Joan Vlayen, Deloitte Diegem BelgiumGuy De Backer, Ghent University Department of Public Health Ghent BelgiumJan Peers, Deloitte Diegem BelgiumIngrid Moldenaers, Deloitte Diegem BelgiumHans Debruyne, Deloitte Diegem BelgiumSteven Simoens, Katholieke Universiteit Leuven Research Centre for Pharmaceutical Care and Pharmaco-economics, Faculty of Pharmaceutical Sciences Onderwijs en Navorsing 2, Herestraat 49 P.O. Box 521 3000 Leuven Belgium Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1805738 Tue, 16 Sep 2008 09:53:18 +0100 1805738 http://www.medworm.com/index.php?rid=1695591&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftv0vg072476j1631%2F Conclusion  A single administration of sTNFR-Fc at the time of reperfusion after myocardial infarction is able to limit infarct size and to reduce early LV diastolic dysfunction in rats. These findings suggest that intravenous neutralization of TNF-α during surgical cardiac reperfusion might improve the outcome of myocardial infarction in humans. Content Type Journal ArticleDOI 10.1007/s10557-008-6130-yAuthors Marie-Claire Toufektsian, Université de Grenoble TIMC-PRETA CNRS (UMR 5525), Equipe Coeur & Nutrition Bât. Jean Roget, Domaine de la Merci Grenoble 38000 FranceVanessa Robbez-Masson, Université de Grenoble TIMC-PRETA CNRS (UMR 5525), Equipe Coeur & Nutrition Bât. Jean Roget, Domaine de la Merci Grenoble 38000 FranceDrissa Sanou, Université de Ouagadougou D�... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1695591 Sat, 09 Aug 2008 12:40:46 +0100 1695591 http://www.medworm.com/index.php?rid=1695592&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa82n601n18vl1713%2F Conclusions  Genetic modulation of heart failure using the βARKct gene was associated with improved exercise capacity and cardiac function as well as amelioration in heart failure-associated profiles of systemic inflammation and volume overload. Content Type Journal ArticleDOI 10.1007/s10557-008-6123-xAuthors Dipin Gupta, New York University Department of Cardiac Surgery New York NY USAEzequiel J. Molina, Temple University School of Medicine Department of Surgery Philadelphia PA USAJon Palma, Temple University School of Medicine Department of Surgery Philadelphia PA USAJohn P. Gaughan, Temple University School of Medicine Department of Physiology Philadelphia PA USAWalter Long, Temple University School of Medicine Department of Microbiology Philadelphia PA USAMahender ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1695592 Sat, 09 Aug 2008 12:40:45 +0100 1695592 http://www.medworm.com/index.php?rid=1685762&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdppm80ktrh557622%2F Conclusion  From these observations, we conclude that pulsatile mechanical pressure is one of the mediators of ACE production in vascular smooth muscle cells and that AII receptor blocking may prevent negative feedback. The present findings may provide a potential therapeutical target beyond lowering blood pressure in hypertensive patients. Content Type Journal ArticleDOI 10.1007/s10557-008-6118-7Authors Kenji Iizuka, Health Sciences University of Hokkaido Department of Pharmacology, Faculty of Pharmaceutical Sciences Ishikari-Tobetsu Hokkaido 061-0293 JapanTakuji Machida, Health Sciences University of Hokkaido Department of Pharmacology, Faculty of Pharmaceutical Sciences Ishikari-Tobetsu Hokkaido 061-0293 JapanHideaki Kawaguchi, Hokkaido University Graduate School of... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1685762 Tue, 05 Aug 2008 07:07:06 +0100 1685762 http://www.medworm.com/index.php?rid=1685761&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm45m1x826148l880%2F Abstract Introduction  Controlling hypertension by angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB), mechanisms that inhibit later pathway steps in the renin–angiotensin system (RAS), have clinically afforded protection against cardiac and renal disease. Materials and methods  In order to determine if blocking the RAS rate-limiting step of angiotensin II generation via renin inhibition could afford similar end organ protection in a human-relevant preclinical model, this study investigated the cardiac and renal effects of a nonpeptide, piperidine renin inhibitor (RI; 100 mg/kg/day PO) in double transgenic mice (dTGM) which express both human renin and angiotensinogen genes. RI was compared to the ARB, candesartan ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1685761 Tue, 05 Aug 2008 07:07:06 +0100 1685761 http://www.medworm.com/index.php?rid=1685760&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwr6127476564k057%2F Conclusion  This is the first study to demonstrate that ginsenoside Rb1 preconditioning has protective effects on myocardial ischemia and reperfusion injury, partly by mediating the activation of the PI3K pathway and phosphorylation of Akt. Content Type Journal ArticleDOI 10.1007/s10557-008-6129-4Authors Zhi Wang, The Second Affiliated Hospital, Sun Yat-sen University Department of Anesthesiology Guangzhou 510120 People’s Republic of ChinaMin Li, Hong Kong Baptist University School of Chinese Medicine Hong Kong ChinaWei-kang Wu, Sun Yat-sen University Department of Pathophysiology, Institute of Integrated Traditional Chinese and Western Medicine, Zhongshan School of Medicine Guangzhou 510080 People’s Republic of ChinaHong-mei Tan, Sun Yat-sen University Department o... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1685760 Tue, 05 Aug 2008 07:07:06 +0100 1685760 http://www.medworm.com/index.php?rid=1685763&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F54p1441272t71163%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6126-7Authors Willem J. Remme, Sticares Cardiovascular Research Institute P.O. Box 882 3160 AB Rhoon The Netherlands Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1685763 Tue, 05 Aug 2008 07:07:04 +0100 1685763 http://www.medworm.com/index.php?rid=1670930&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe64r84q0681328t1%2F Conclusion  Rosiglitazone significantly inhibited VSMC proliferation, at least in part by inhibiting high glucose-induced G1→S phase transition, PCNA expression and MMP-2 synthesis. Content Type Journal ArticleDOI 10.1007/s10557-008-6127-6Authors Hong-Yan Ling, Central South University Department of Pharmacology, School of Pharmaceutical Sciences Changsha 410078 ChinaBi Hu, University of South China Department of Physiology Hengyang 421001 ChinaBing-Xiang Wang, Taishan Medical Collage Department of Physiology Taian 271000 ChinaXu-Yu Zu, University of South China Division of Pharmacoproteomics, The Institute of Pharmacy & Pharmacology Hengyang 421001 Hunan People’s Republic of ChinaShui-Dong Feng, University of South China Department of Epidemiology Hengyang 421001 Ch... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1670930 Wed, 30 Jul 2008 08:10:15 +0100 1670930 http://www.medworm.com/index.php?rid=1645262&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1557257214237536%2F Conclusion  Avoid anticoagulation with heparins in patients with acute ischemic stroke with atrial fibrillation for 7–10 days. Further studies are needed to delineate when to start oral anticoagulation. Content Type Journal ArticleCategory ReviewDOI 10.1007/s10557-008-6122-yAuthors Abhimanyu Beri, Michigan State University Department of Internal Medicine 3140 Staten Ave Apt 5 Lansing MI 48910 USASujeeth Reddy Punnam, Michigan State University Division of Cardiology, Department of Internal Medicine East Lansing USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1645262 Mon, 21 Jul 2008 05:54:31 +0100 1645262 http://www.medworm.com/index.php?rid=1634414&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff710450k42m46377%2F Content Type Journal ArticleCategory ReviewDOI 10.1007/s10557-008-6125-8Authors Natalia Landázuri, Emory University School of Medicine Division of Cardiology, Department of Medicine Atlanta GA USAW. Robert Taylor, Emory University School of Medicine Division of Cardiology, Department of Medicine Atlanta GA USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1634414 Wed, 16 Jul 2008 06:06:40 +0100 1634414 http://www.medworm.com/index.php?rid=1605310&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd367k333g4172r20%2F Conclusion  Taurine enhances contractions in IR aortic rings but relaxes the contractions in normal rat aortic ring; the enhancement is endothelium-dependent and the relaxation is endothelium-independent. TEA-sensitive K+ channel may be involved in these actions; BKCa channel dysfunction and endothelium-derived substances may be related to the contraction enhancement induced by taurine in IR aorta. Content Type Journal ArticleDOI 10.1007/s10557-008-6124-9Authors Wenxin Xue, Shanxi Medical University Department of Pharmacology Xinjian South Road 56 Taiyuan 030001 Shanxi Province ChinaMingsheng Zhang, Shanxi Medical University Department of Pharmacology Xinjian South Road 56 Taiyuan 030001 Shanxi Province ChinaJie Li, Shanxi Medical University Department of Pharmacology ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1605310 Wed, 09 Jul 2008 06:23:40 +0100 1605310 http://www.medworm.com/index.php?rid=1563277&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9643675223870l78%2F Abstract Introduction  Early risk stratification of patients with acute coronary syndromes (ACS), unstable angina, or non-ST-elevation myocardial infarction ensures patients receive appropriate care. Materials and methods  Many risk-stratification models have been developed to identify high-risk ACS patients who would benefit most from an early invasive strategy and to determine patients at greater risk for bleeding complications. Although high-risk patients seem to benefit most from a combination of aggressive antithrombotic and early invasive therapies, stratification for risk of bleeding also helps in the choice and dosing of appropriate medical therapy. Results  The effective use of glycoprotein IIb/IIIa inhibitors, in particular, is dep... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1563277 Tue, 01 Jul 2008 06:31:47 +0100 1563277 http://www.medworm.com/index.php?rid=1534938&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9g3k64810k7588k8%2F Conclusion  We demonstrated an infarct sparing effect for postC in the working heart model, which unlike the Langendorff model, was not associated with functional preservation. The infarct sparing effect of postC in both models was however extremely sensitive to even slight fluctuations in temperature. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s10557-008-6119-6Authors Derick van Vuuren, University of Stellenbosch Department of Biomedical Sciences, Division of Medical Physiology, Faculty of Health Sciences P.O. Box 19063 Tygerberg 7505 Republic of South AfricaAmanda Genis, University of Stellenbosch Department of Biomedical Sciences, Division of Medical Physiology, Faculty of Health Sciences P.O. Box 19063 Tygerberg 7505 Republic of South Afric... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1534938 Thu, 19 Jun 2008 08:18:32 +0100 1534938 http://www.medworm.com/index.php?rid=1530478&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb63mj1g45r41g103%2F Conclusion  The results of 3T/2R study will evaluate whether tailored intensification of anti-platelet treatment based on poor individual response to oral anti-platelet agents may modulate the risk of periprocedural myocardial infarction during PCI. Our findings attempt at unraveling a new era of individualized anti-platelet treatment through the use of point-of-care assessment. Content Type Journal ArticleDOI 10.1007/s10557-008-6121-zAuthors Marco Valgimigli, Arcispedale S. Anna Hospital University of Ferrara, Cardiovascular Institute Corso Giovecca 203 44100 Ferrara ItalyGianluca Campo, Arcispedale S. Anna Hospital University of Ferrara, Cardiovascular Institute Corso Giovecca 203 44100 Ferrara ItalyNicoletta de Cesare, Policlinico S. Marco Zingonia (BG) ItalyPascal ... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1530478 Tue, 17 Jun 2008 10:07:13 +0100 1530478 http://www.medworm.com/index.php?rid=1521737&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1823127245k87g53%2F Conclusion  Statins cause modest increases in HDL-C and apo A-I probably mediated by reductions in CETP activity. It is plausible that such changes independently contribute to the cardiovascular benefits of the statin class but more studies are needed to further explore this possibility. Content Type Journal ArticleDOI 10.1007/s10557-008-6113-zAuthors Fergus McTaggart, AstraZeneca Clinical Development Mereside, Alderley Park Macclesfield Cheshire SK10 4TG UKPeter Jones, Baylor College of Medicine Section of Cardiology, Department of Medicine One Baylor Plaza, Room 525D Houston TX 77030 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1521737 Sat, 14 Jun 2008 05:56:06 +0100 1521737 http://www.medworm.com/index.php?rid=1499265&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1h0143g060454060%2F Conclusions  Bisoprolol and enalapril had a similar effect on the combined end-point of mortality or hospitalization during 6 months monotherapy. However, more worsening HF events were observed in the bisoprolol group. Content Type Journal ArticleDOI 10.1007/s10557-008-6116-9Authors Daniela Dobre, University Medical Centre Groningen, University of Groningen Department of Clinical Pharmacology Antonius Deusinglaan 1 9713 AV Groningen The NetherlandsDirk J. van Veldhuisen, University Medical Centre Groningen, University of Groningen Department of Cardiology, Thoraxcenter Groningen The NetherlandsMichael A. Goulder, Nottingham Clinical Research Limited Nottingham UKHenry Krum, Monash University/Alfred Hospital Department of Clinical Pharmacology and Therapeutics Melbo... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1499265 Thu, 05 Jun 2008 09:59:20 +0100 1499265 http://www.medworm.com/index.php?rid=1499266&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgh31j32462103214%2F Conclusion  The systemic administration of G-CSF plus EPO during the first week after balloon-injury impairs the vascular healing process by increasing the neointimal response and the risk for thrombotic occlusion. Content Type Journal ArticleDOI 10.1007/s10557-008-6117-8Authors Michael Hack, Regensburg University Medical Center Department of Internal Medicine II 93053 Regensburg GermanyFrank G. Mascha, Regensburg University Medical Center Department of Internal Medicine II 93053 Regensburg GermanyBertram Jobst, Regensburg University Medical Center Department of Internal Medicine II 93053 Regensburg GermanyGuenter A. J. Riegger, Regensburg University Medical Center Department of Internal Medicine II 93053 Regensburg GermanyDaniel P. Griese, Regensburg University Medical... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1499266 Thu, 05 Jun 2008 09:59:18 +0100 1499266 http://www.medworm.com/index.php?rid=1493989&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm8rw716328232135%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6102-2Authors Nikolaus Marx, University of Ulm Department of Internal Medicine II, Cardiology Robert-Koch-Str. 8 89081 Ulm Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1493989 Tue, 03 Jun 2008 06:11:05 +0100 1493989 http://www.medworm.com/index.php?rid=1469134&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh2k1150460385v83%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6111-1Authors Ferdinand H. Bahlmann, University of the Saarland Department of Medicine IV Kirrbergerstrasse, Geb. 40 66421 Homburg/Saar Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1469134 Sat, 24 May 2008 07:22:04 +0100 1469134 http://www.medworm.com/index.php?rid=1466728&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn4674n6q8051p267%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6114-yAuthors Dietlind Zohlnhöfer, Deutsches Herzzentrum München Klinik für Erwachsenenkardiologie Lazarettstrasse, 36 80636 Munich Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1466728 Fri, 23 May 2008 05:51:57 +0100 1466728 http://www.medworm.com/index.php?rid=1436289&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft34366q815030270%2F Conclusion  We conclude that fasudil administered before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium. Content Type Journal ArticleDOI 10.1007/s10557-008-6106-yAuthors Itsuko Shibata, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanOsamu Yoshitomi, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanTadasuke Use, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanHiroyuki Ureshino, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanSungsam Cho, Nagasaki University School of Medicine Departme... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1436289 Sat, 10 May 2008 08:24:15 +0100 1436289 http://www.medworm.com/index.php?rid=1436288&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F322205x2l153v718%2F Content Type Journal ArticleCategory Heart GroupDOI 10.1007/s10557-008-6112-0 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy) Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1436288 Sat, 10 May 2008 08:24:15 +0100 1436288 http://www.medworm.com/index.php?rid=1436291&cid=s_33443_7_f&fid=33443&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj140q233048h11n5%2F Conclusion  Pioglitazone inhibited cadiocyte apoptosis and reduced mitochondrial ultrastructure injury and membrane potential loss in the ischemic/reperfused heart of rat. These protective effects of pioglitazone may be related to opening mitochondrialATP-sensitive potassium channels. Content Type Journal ArticleDOI 10.1007/s10557-008-6115-xAuthors Jian Li, Huazhong University of Science and Technology Department of Cardiology, Union Hospital, Tongji Medical College No.1277 Jiefang Road Wuhan 430022 ChinaMing-Jian Lang, Huazhong University of Science and Technology Department of Cardiology, Union Hospital, Tongji Medical College No.1277 Jiefang Road Wuhan 430022 ChinaXiao-Bo Mao, Huazhong University of Science and Technology Department of Cardiology, Union Hospital, Ton... Cardiovascular Drugs and Therapy journals http://www.medworm.com/rss/comments.php?id=1436291 Sat, 10 May 2008 08:24:14 +0100 1436291