MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cardiovascular Pathology' source. Wed, 17 Mar 2010 13:59:30 +0100 http://www.medworm.com/index.php?rid=3228686&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880710000062%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228686 Tue, 02 Feb 2010 14:01:16 +0100 3228686 http://www.medworm.com/index.php?rid=3228685&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880710000050%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228685 Tue, 02 Feb 2010 14:01:16 +0100 3228685 http://www.medworm.com/index.php?rid=3057821&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709001392%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057821 Sat, 05 Dec 2009 13:50:30 +0100 3057821 http://www.medworm.com/index.php?rid=3057820&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709001380%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057820 Sat, 05 Dec 2009 13:50:30 +0100 3057820 http://www.medworm.com/index.php?rid=3057810&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000751%2Fabstract%3Frss%3Dyes Abstract: The “metamorphosis” of acute myocardial infarction (AMI) in terms of pathological features and complications in the reperfusion era is herein discussed. Typically, the AMI following coronary artery recanalization is characterized by frequent subendocardial location, since a prompt coronary lumen recanalization is able to prevent the transmural progression of myocardial necrosis from the endocardium towards the epicardium. Transmural AMI may develop when recanalization occurs late (>6 hours) or is not effective (persistent coronary occlusion). Moreover, reperfused AMI frequently appears reddish because of interstitial haemorrhage, which is thought to be caused by vascular cell damage with leakage of blood out of the injured vessels. Hemorrhage occurs always within the area of ... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057810 Sat, 05 Dec 2009 13:50:28 +0100 3057810 http://www.medworm.com/index.php?rid=2951752&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709001203%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951752 Sun, 01 Nov 2009 00:00:00 +0100 2951752 http://www.medworm.com/index.php?rid=2951751&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709001197%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951751 Sun, 01 Nov 2009 00:00:00 +0100 2951751 http://www.medworm.com/index.php?rid=3057807&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000969%2Fabstract%3Frss%3Dyes Abstract: Hospital mortality for acute myocardial infarction declined from 30% to 10% in the last 30 years, thanks to coronary care units and early revascularization with thrombolysis, angioplasty, and stent implantation. Pathologists played a major role by establishing plaque rupture and coronary thrombosis as the major cause of acute myocardial infarction and by discovering that ischemic myocardium necrosis progresses from endocardium to epicardium as a “wave front” phenomenon, with potential reversible injury if the reperfusion is accomplished within 3 h. Long-term mortality following myocardial infarction is mostly due to sudden electrical death, which may be prevented by pharmacologic (antiarrhythmic drugs) and nonpharmacologic (implantable cardioverter defibrillator, pacemaker) t... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057807 Thu, 24 Sep 2009 00:00:00 +0100 3057807 http://www.medworm.com/index.php?rid=2763503&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000908%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763503 Mon, 31 Aug 2009 23:00:00 +0100 2763503 http://www.medworm.com/index.php?rid=2763502&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000891%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763502 Mon, 31 Aug 2009 23:00:00 +0100 2763502 http://www.medworm.com/index.php?rid=2564375&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000520%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564375 Tue, 30 Jun 2009 23:00:00 +0100 2564375 http://www.medworm.com/index.php?rid=2564374&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000519%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564374 Tue, 30 Jun 2009 23:00:00 +0100 2564374 http://www.medworm.com/index.php?rid=2370581&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000349%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370581 Tue, 28 Apr 2009 23:58:03 +0100 2370581 http://www.medworm.com/index.php?rid=2370580&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000337%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370580 Tue, 28 Apr 2009 23:58:03 +0100 2370580 http://www.medworm.com/index.php?rid=2370579&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000380%2Fabstract%3Frss%3Dyes Conclusions: The present case showed morphologic and immunohistochemical features characteristic of IMT. Immunohistochemistry was helpful for characterization and differential diagnosis. The immunoreactivity pattern (including calponin expression) was similar to that of extracardiac IMTs except for anaplastic lymphoma kinase 1 immunoreactivity, lacking in this benign intracardiac IMT but usually associated to favourable prognosis in extracardiac IMTs. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370579 Tue, 28 Apr 2009 23:57:58 +0100 2370579 http://www.medworm.com/index.php?rid=2370578&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000069%2Fabstract%3Frss%3Dyes Conclusions: Asymptomatic hypothyroidism may cause severe reduction in cardiac function accompanied with elevated cardiac enzymes. To our knowledge, this is the first description of human myocardial biopsy revealing mucopolysaccharide accumulation attributed to hypothyroid state. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370578 Tue, 28 Apr 2009 23:57:57 +0100 2370578 http://www.medworm.com/index.php?rid=2370577&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880707002074%2Fabstract%3Frss%3Dyes Conclusion: Management of metastatic adenocarcinoma to the heart is not well established due to the rarity of this lesion. Previously reported cases vary in the therapeutic approach as well as the outcome. To this date the best outcome has been a survival of 6 years after treatment of the metastasis with radiotherapy and concurrent cisplatin and pegylated liposomal doxorubicin. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370577 Tue, 28 Apr 2009 23:57:46 +0100 2370577 http://www.medworm.com/index.php?rid=2370576&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000422%2Fabstract%3Frss%3Dyes Abstract: Background: Myxomas are the most frequent primary cardiac neoplasms. They have an abundant extracellular matrix rich in proteoglycans. Interactions between cells and matrix are very important in the development of tumors, but data about myxomas in this setting are scarce because of the rarity of such neoplasms. The expression of tenascin-c and hyaluran receptors in cardiac myxoma has never been investigated. Moreover, it is now well recognized that cells of cardiac myxoma differentiate along endothelial lines.Methods: We have analyzed left atrial myxomas from 13 consecutive patients (six male and seven female, surgically treated), via immunohistochemical methods for the expression of molecules also implicated in angiogenesis in normal and pathological conditions, like tenascin-c ... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370576 Tue, 28 Apr 2009 23:57:44 +0100 2370576 http://www.medworm.com/index.php?rid=2370575&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000446%2Fabstract%3Frss%3Dyes Conclusions: The H2O2 responsive pre-mRNA binding protein hnRNP-C is up-regulated in atherosclerosis and in preatherosclerotic intimal hyperplasia in humans, supporting the hypothesis that H2O2 is a regulator of vascular cell proliferation in these conditions. These data also suggest that hnRNP-C may be useful as a marker of vascular cell activation. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370575 Tue, 28 Apr 2009 23:57:39 +0100 2370575 http://www.medworm.com/index.php?rid=2370574&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000045%2Fabstract%3Frss%3Dyes Conclusion: Our findings indicate that during NADPH oxidase deficiency, superoxide production can be compensated by other sources, which leads to cardiac oxidative stress and its related molecular/cellular events in the infarcted heart. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370574 Tue, 28 Apr 2009 23:57:36 +0100 2370574 http://www.medworm.com/index.php?rid=2370573&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000392%2Fabstract%3Frss%3Dyes Conclusions: We established significant gender-specific disparities in the aortic root during aging: while aortic sinus curvature was high in females throughout their lives, it experienced a more than fourfold increase in the lifetime of males, matching values in females only by age 65. Our mechanical analyses confirmed the overall potential protective role of higher sinus wall curvature with respect to type A aortic dissection, and geometry alone could not account for the known gender difference in aortic dissection prevalence. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370573 Tue, 28 Apr 2009 23:57:33 +0100 2370573 http://www.medworm.com/index.php?rid=2370572&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000379%2Fabstract%3Frss%3Dyes Abstract: Background: Fibrates are peroxisome proliferator-activated receptor α (PPARα) agonists which modulate many aspects of lipoprotein metabolism and inflammation. They have been recently demonstrated to inhibit in vitro expression of tissue factor (TF), the main initiator of blood coagulation, which probably plays a pivotal role in thrombotic complications after plaque rupture. We investigated whether a 4-week fenofibrate treatment might affect the TF expression and cellular modifications in angioplasty-induced rabbit plaque rupture.Methods: After plaque rupture by balloon angioplasty in atheromatous rabbits, animals were randomized in an untreated group or a group receiving fenofibrate. The TF content of arterial wall and the histological modifications were analyzed after 4 weeks.... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370572 Tue, 28 Apr 2009 23:57:29 +0100 2370572 http://www.medworm.com/index.php?rid=2370571&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000549%2Fabstract%3Frss%3Dyes Abstract: A total of 338 surgical specimens of the thoracic aorta were studied morphologically. These were obtained from patients (238 males, 100 females) operated on for aortic aneurysm or dissection at the Careggi Hospital, Florence, Italy, between January 1999 and June 2005. Medial degeneration was diagnosed in 299 cases (138 aneurysms, 161 dissections), atherosclerosis with extensive medial destruction was seen in 32 cases (26 aneurysms, 6 dissections), and giant cell arteritis (GCA) was found in 7 cases (all aneurysms). These data show that medial degeneration was a common nonspecific histologic diagnosis in aortic resection after the occurrence of aneurysm or dissection. Considering that this diagnosis was made in as many as 118 patients over 70 years of age and in 175 patients over ... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370571 Tue, 28 Apr 2009 23:57:27 +0100 2370571 http://www.medworm.com/index.php?rid=2370570&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000040%2Fabstract%3Frss%3Dyes We describe a practical, rapid and cost-effective method to dissolve most metallic stents leaving the vascular and luminal tissues intact. This practical method may replace the laborious and expensive plastic embedding methods currently utilized. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2370570 Tue, 28 Apr 2009 23:57:26 +0100 2370570 http://www.medworm.com/index.php?rid=3228679&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001907%2Fabstract%3Frss%3Dyes Abstract: Background: Long QT syndrome (LQTS) is among arrhythmia disorders of the heart that causes sudden cardiac death in young individuals. As yet, most of investigations have focused on nuclear genome for finding genetic defects in this disorder, but some of the cases with LQTS cannot be explained by mutations of identified genes. On the other hand, it has been reported that the activity of ion channels in cardiomyocytes is sensitive to ATP level. It prompted us to focus on the mitochondrial DNA and monitor the point mutations of genome which are probably the cause of respiratory chain defects and reduced ATP generation.Methods: We searched about 55% of the mitochondrial DNA (mtDNA) by temporal temperature gradient gel electrophoresis (TTGE), and DNA fragments showing abnormal banding... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228679 Wed, 15 Apr 2009 00:00:00 +0100 3228679 http://www.medworm.com/index.php?rid=2342850&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS105488070900012X%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342850 Sun, 01 Mar 2009 05:00:00 +0100 2342850 http://www.medworm.com/index.php?rid=2342849&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880709000118%2Fabstract%3Frss%3Dyes (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342849 Sun, 01 Mar 2009 05:00:00 +0100 2342849 http://www.medworm.com/index.php?rid=2342848&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880707002104%2Fabstract%3Frss%3Dyes We report herein a case of sporadic primary cardiac bi-atrial Burkitt lymphoma (BL) occurred in a 67-year-old white immunocompetent patient and presenting with signs and symptoms of severe bilateral atrioventricular inflow impairment. Extranodal BL involving the heart is rare and seldom recognized clinically. Delayed discovery contributes to significant mortality. In the case presented extended surgical excision and intensive combination chemotherapy regiments resulted in complete remission at 1 year. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342848 Sun, 01 Mar 2009 05:00:00 +0100 2342848 http://www.medworm.com/index.php?rid=2342847&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880707002062%2Fabstract%3Frss%3Dyes Abstract: A 31-year-old woman with partial atrioventricular septal defect underwent left atrioventricular valve (LAVV) replacement. Her initial repair was at 8 years of age. At 23 years of age, she underwent reoperation due to a combination of severe left ventricular outlet obstruction and moderate LAVV regurgitation. At that reoperation, she had a Dacron patch enlargement of the infundibular septum and repair of her LAVV with a xenograft (bovine) pericardial patch sutured into the superior bridging leaflet. LAVV replacement was required 8 years later because of valve insufficiency. There was a perforation in the patch with fibrosis, thickening due to pannus, and calcification of the pericardial tissue and the leaflet tissue, leading to stiffening of the tissue. (Source: Cardiovascular Pat... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342847 Sun, 01 Mar 2009 05:00:00 +0100 2342847 http://www.medworm.com/index.php?rid=2342846&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880707001925%2Fabstract%3Frss%3Dyes We report a case of massive pericardial hydatidosis in a female patient who presented with features of congestive cardiac failure. Cysts in the endocardium of right side of the heart resulted in fatal pulmonary embolism. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342846 Sun, 01 Mar 2009 05:00:00 +0100 2342846 http://www.medworm.com/index.php?rid=2342845&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880707001883%2Fabstract%3Frss%3Dyes This report illustrates the serial imaging of a primary cardiac undifferentiated sarcoma of the right atrium using echocardiography, chest X-ray, and computed tomography. Transthoracic echocardiography on presentation showed an extensive mass of the right atrial free wall with an impending cardiac tamponade. Symptoms were controlled with pericardiocentesis, pericardial window, and radiotherapy but recurred 8 months later with pleural effusion and tumor spread to the great arteries. Primary cardiac sarcoma (PSC) is a rare and aggressive malignancy that is usually diagnosed late due to its nonspecific symptoms. Cytology and cardiac biopsy may be negative, and suspicion for the tumor is warranted in recurrent pericardial effusion. Analogous to parietal pleural biopsy in lung tumors with pleur... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342845 Sun, 01 Mar 2009 05:00:00 +0100 2342845 http://www.medworm.com/index.php?rid=2342844&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000367%2Fabstract%3Frss%3Dyes Conclusions: Our results suggest that folic acid and methionine periconceptional supplementations may influence the incidence of congenital defects and may probably induce negative selection of embryos presenting developmental anomalies. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342844 Sun, 01 Mar 2009 05:00:00 +0100 2342844 http://www.medworm.com/index.php?rid=2342843&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000112%2Fabstract%3Frss%3Dyes Conclusion: In this single case, comparative genomic hybridization analysis using both bacterial artificial chromosome and oligonucleotide arrays correlated well with cytogenetic findings and allows for the cataloguing of more subtle genomic events. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342843 Sun, 01 Mar 2009 05:00:00 +0100 2342843 http://www.medworm.com/index.php?rid=2342842&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000100%2Fabstract%3Frss%3Dyes Conclusions: Local variations in tissue thickness and mechanical properties were evident in all samples analyzed and may be linked to the type of aortic valve present. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342842 Sun, 01 Mar 2009 05:00:00 +0100 2342842 http://www.medworm.com/index.php?rid=2342841&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000094%2Fabstract%3Frss%3Dyes Abstract: Introduction: Osteopontin (OPN) is a potent inhibitor of ectopic calcification. Previous studies suggested that, in addition to blocking apatite crystal growth, OPN promoted regression of ectopic calcification by inducing the expression of acid-generating carbonic anhydrase II (CAR2) in monocyte-derived cells.Methods: To test this hypothesis, OPN and CAR2 expression and calcification of subcutaneously implanted glutaraldehyde-fixed bovine pericardium (GFBP) were studied in CAR2 mutant mice.Results: Consistent with previous studies in Black Swiss mice, GFBP calcified to a greater extent in OPN-deficient mice compared to wild types on the C57Bl/6 background. GFBP implanted in CAR2-deficient mice (CAR2−/−) were significantly more calcified than those implanted into wild-type mic... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342841 Sun, 01 Mar 2009 05:00:00 +0100 2342841 http://www.medworm.com/index.php?rid=2342840&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000057%2Fabstract%3Frss%3Dyes Conclusions: Experimental AVS lesions that are present on the aortic side of leaflets display numerous characteristics of vascular atherosclerosis, including TF expression. Identification of TF associated with other components of the atherosclerotic process in AVS lesions strengthens the link between atherosclerosis and AVS. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2342840 Sun, 01 Mar 2009 05:00:00 +0100 2342840 http://www.medworm.com/index.php?rid=2210866&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230715%26dopt%3DAbstract Authors: Bestetti RB, Silva CM, Ardito SQ, Theodoropoulos TA, Cury PM, Corbucci HA A 24-year-old-man had right-sided heart failure of 3 months' duration. A Doppler echocardiogram revealed atrium and right ventricular enlargement, obliteration of the right ventricular apex, and a mass with an echolucent center measuring 20x21 mm in the right ventricular outlet. He died of pulmonary embolism. At autopsy, a huge organized thrombus obliterating the right ventricular apex passing through the tricuspid valve to the right atrium and then extending to the inferior vena cava up to the suprahepatic veins was seen. Histologically, an intense fibrotic thickening of the endomyocardium extending into the myocardium was observed. Cardiac thrombosis associated with endomyocardial fibrosis should be ad... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2210866 Thu, 19 Feb 2009 05:00:00 +0100 2210866 http://www.medworm.com/index.php?rid=3228671&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001828%2Fabstract%3Frss%3Dyes Abstract: Background: Murine cytomegalovirus (MCMV) is an etiologic agent of acute and chronic myocarditis in BALB/c mice. Immunologic host responses appear to play a key role in pathogenesis but have been incompletely defined.Methods: BALB/c mice were infected with a sublethal dose of MCMV. Cytokine transcription and viral load (measured by quantitative real-time polymerase chain reaction) and histopathological analyses were performed at specified time points.Results: Increased tumor necrosis factor (TNF)-α, interleukin (IL)-6, and interferon (IFN)-γ, as well as IL-10 mRNA transcripts, were detected in the hearts of infected mice starting at Day 1 post-infection (p.i.), with peak levels occurring at Day 8 p.i. (7-fold, 14-fold, 41-fold, and 16-fold higher than background, respectively).... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228671 Tue, 17 Feb 2009 00:00:00 +0100 3228671 http://www.medworm.com/index.php?rid=2190786&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19217318%26dopt%3DAbstract CONCLUSIONS: MCMV-induced myocarditis in BALB/c mice is characterized by in vivo production of proinflammatory cytokines in a pattern correlating with MCMV viral load. The infection pattern and inflammatory response is highly localized, sporadic, and involves endocardium, epicardium, as well as the myocardium, with greatest amounts of virus detected in areas of pathologic calcification. PMID: 19217318 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2190786 Thu, 12 Feb 2009 05:00:00 +0100 2190786 http://www.medworm.com/index.php?rid=3228678&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001877%2Fabstract%3Frss%3Dyes Conclusions: These findings suggest a novel role for several human AIE genes in the VSMC response to arterialization and extended cyclic strain.Summary: Biomechanical stress has long been implicated in vascular pathologies. We report the novel finding of a group of genes, previously studied in stratified epithelium, that were regulated by prolonged cyclic stress in vascular smooth muscle cells. This may have important implications to vascular disease. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228678 Thu, 12 Feb 2009 00:00:00 +0100 3228678 http://www.medworm.com/index.php?rid=3228673&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001713%2Fabstract%3Frss%3Dyes Conclusions: AF is closely associated with an atrial up-regulation of hypoxic and angiogenic markers. Whether this is cause, effect, or co-phenomenon of fibrosis remains to be investigated. It is conceivable that fibrosis might lead to an increased O2 diffusion distance and thus induce ischemic signaling, which, in turn, leads to angiogenesis. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228673 Thu, 12 Feb 2009 00:00:00 +0100 3228673 http://www.medworm.com/index.php?rid=2951742&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001853%2Fabstract%3Frss%3Dyes Abstract: Background: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism of the transition from hypertrophy to dysfunction has not been elucidated. It has been reported that circulating levels of monocyte chemoattractant protein-1 (MCP-1), which is a major factor promoting the accumulation of macrophages, are increased in patients with congestive heart failure. We measured circulating levels of MCP-1 in patients with HCM and examined whether MCP-1 was expressed in the myocardium of HCM patients. We also examined whether circulating levels of MCP-1 were correlated with left ventricular dysfunction.Methods: Circulating levels of MCP-1 were measured by an enzyme immunoassay in 26 patients with HCM (... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951742 Thu, 12 Feb 2009 00:00:00 +0100 2951742 http://www.medworm.com/index.php?rid=2188113&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19216095%26dopt%3DAbstract We report a rare case of a neonate with congenital giant aortic aneurysm associated to cleft sternum, who underwent surgical repair. The patient died on postoperative Day 5 from cardiac arrest. Autopsy revealed a circumferential subendocardial myocardial infarction and misdiagnosed coronary ostial anomalies. A critical analysis of this unfortunate case may help optimal surgical planning in similar patients in the future. PMID: 19216095 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2188113 Wed, 11 Feb 2009 05:00:00 +0100 2188113 http://www.medworm.com/index.php?rid=2182791&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211265%26dopt%3DAbstract CONCLUSION: This study validates the use of TMA technology to investigate the vascular wall utilizing staining intensity data. PMID: 19211265 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182791 Tue, 10 Feb 2009 05:00:00 +0100 2182791 http://www.medworm.com/index.php?rid=2182790&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211266%26dopt%3DAbstract CONCLUSION: These results show that MCP-1 is associated with, and might be involved in the pathogenesis of, left ventricular systolic dysfunction in patients with HCM. PMID: 19211266 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182790 Tue, 10 Feb 2009 05:00:00 +0100 2182790 http://www.medworm.com/index.php?rid=2182789&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211267%26dopt%3DAbstract CONCLUSIONS: AF is closely associated with an atrial up-regulation of hypoxic and angiogenic markers. Whether this is cause, effect, or co-phenomenon of fibrosis remains to be investigated. It is conceivable that fibrosis might lead to an increased O(2) diffusion distance and thus induce ischemic signaling, which, in turn, leads to angiogenesis. PMID: 19211267 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182789 Tue, 10 Feb 2009 05:00:00 +0100 2182789 http://www.medworm.com/index.php?rid=2182788&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211268%26dopt%3DAbstract We describe a practical, rapid and cost-effective method to dissolve most metallic stents leaving the vascular and luminal tissues intact. This practical method may replace the laborious and expensive plastic embedding methods currently utilized. PMID: 19211268 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182788 Tue, 10 Feb 2009 05:00:00 +0100 2182788 http://www.medworm.com/index.php?rid=2182787&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211269%26dopt%3DAbstract Authors: Roberts WC, Patterson BA, Ko JM, Sager RA, Clark JA, Guileyardo JM Certain clinical and cardiac morphologic findings are presented in two men who developed massive right ventricular (RV) infarction with only minimal or no left ventricular infarction early after aortic valve replacement. The ostium of the right coronary artery was severely narrowed in one patient by the ring of the bioprosthesis, and in the other patient the right coronary artery was completely severed at the time of valve replacement without insertion of a coronary bypass conduit. Such massive infarction of the RV free wall has not been reported previously. PMID: 19211269 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182787 Tue, 10 Feb 2009 05:00:00 +0100 2182787 http://www.medworm.com/index.php?rid=2182786&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211270%26dopt%3DAbstract CONCLUSIONS: These findings suggest a novel role for several human AIE genes in the VSMC response to arterialization and extended cyclic strain. SUMMARY: Biomechanical stress has long been implicated in vascular pathologies. We report the novel finding of a group of genes, previously studied in stratified epithelium, that were regulated by prolonged cyclic stress in vascular smooth muscle cells. This may have important implications to vascular disease. PMID: 19211270 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182786 Tue, 10 Feb 2009 05:00:00 +0100 2182786 http://www.medworm.com/index.php?rid=2182785&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211271%26dopt%3DAbstract CONCLUSION: AF does not independently effect atrial eNOS expression in humans. Due to the nonuniform regulation of endocardial eNOS expression, it appears unlikely that down-regulation of eNOS is a final common pathway for the development of prothrombotic endocardial remodeling, since classical risk factors for thromboembolic events do not reduce endocardial eNOS protein. PMID: 19211271 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182785 Tue, 10 Feb 2009 05:00:00 +0100 2182785 http://www.medworm.com/index.php?rid=2182784&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211272%26dopt%3DAbstract CONCLUSIONS: Melanoma is known to have an unpredictable and prolonged course. Neoplastic involvement of the heart should be considered in patients with cardiac symptoms when a documented malignancy exists, no matter how remote. PMID: 19211272 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182784 Tue, 10 Feb 2009 05:00:00 +0100 2182784 http://www.medworm.com/index.php?rid=2182783&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211273%26dopt%3DAbstract Authors: Dubi S, Arbel Y Diastolic heart failure (DHF) or heart failure with preserved systolic left ventricular function is estimated to account for approximately 40% of heart failure cases. Medical treatment of patients with DHF is limited and mainly empirical. Device-based therapy has an increasing role in the treatment of systolic heart failure and may have a future role in the treatment of DHF patients. Diastolic dysfunction and DHF are associated with anatomical and physiological characteristics, which need to be modeled in large animals in order to allow evaluation of device-based therapies, prior to clinical studies. In this article, we will review the large animal models for diastolic dysfunction and heart failure. PMID: 19211273 [PubMed - as supplied by publisher] (Source... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182783 Tue, 10 Feb 2009 05:00:00 +0100 2182783 http://www.medworm.com/index.php?rid=2182782&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19211274%26dopt%3DAbstract Authors: Gupta K, Das A, Joshi K, Singh N, Aggarwal R, Prakash M Invasive aspergillosis is an emerging infection mainly affecting immunocompromised patients. Aspergillus endocarditis remains a rare infection and usually occurs following cardiac surgery for prosthetic valves. This is an uncommon case of a 60-year-old asthmatic male who developed allergic bronchopulmonary aspergillosis during the course of his illness, and while receiving low dose oral steroids, he subsequently developed right-sided Aspergillus mural and native valvular endocarditis with extensive invasive pulmonary aspergillosis. PMID: 19211274 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2182782 Tue, 10 Feb 2009 05:00:00 +0100 2182782 http://www.medworm.com/index.php?rid=3057809&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001865%2Fabstract%3Frss%3Dyes Abstract: The interventional treatment of ischemia is a complex issue grounded on an understanding of basic pathophysiology, but translated and implemented in practice by extensive clinical trial data representing patients with a spectrum of ischemia-causing clinical syndromes and anatomical variations of coronary artery disease (CAD). Percutaneous coronary intervention (PCI) has evolved to treat ischemia within this matrix of clinical and anatomical subsets using a wide array of techniques. Initial techniques using balloon angioplasty were promising, but demonstrated significant rates of restenosis due to negative arterial remodeling. The advent of stent technology prevented arterial recoil and provided a viable treatment for flow-limiting coronary dissections, thereby facilitating improv... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057809 Fri, 06 Feb 2009 00:00:00 +0100 3057809 http://www.medworm.com/index.php?rid=2173121&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200756%26dopt%3DAbstract Authors: Hudson PA, Kim MS, Carroll JD The interventional treatment of ischemia is a complex issue grounded on an understanding of basic pathophysiology, but translated and implemented in practice by extensive clinical trial data representing patients with a spectrum of ischemia-causing clinical syndromes and anatomical variations of coronary artery disease (CAD). Percutaneous coronary intervention (PCI) has evolved to treat ischemia within this matrix of clinical and anatomical subsets using a wide array of techniques. Initial techniques using balloon angioplasty were promising, but demonstrated significant rates of restenosis due to negative arterial remodeling. The advent of stent technology prevented arterial recoil and provided a viable treatment for flow-limiting coronary dissect... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2173121 Wed, 04 Feb 2009 05:00:00 +0100 2173121 http://www.medworm.com/index.php?rid=3057813&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001580%2Fabstract%3Frss%3Dyes Abstract: Background: The role of Chlamydia pneumoniae in peripheral atherosclerosis disease and abdominal aortic aneurysm (AAA) remains unclear. Chlamydial lipopolysaccharide (cLPS) detection is a method used conventionally in routine chlamydial diagnosis of gynecological or ophthalmic samples.Methods: We compared cLPS concentrations, as well as other markers of bacterial load, in plaques and sera of patients operated on for carotid artery stenosis (n=110), aorto-occlusive disease (n=22), or AAAs (n=50) at the Helsinki University Central Hospital.Results: The median levels of cLPS in plaques were 2.28, 0.80, and 0.29 ng/ml in AAA, aorto-occlusive disease, and carotid artery stenosis patients, respectively (P (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057813 Fri, 16 Jan 2009 00:00:00 +0100 3057813 http://www.medworm.com/index.php?rid=2951743&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001531%2Fabstract%3Frss%3Dyes Abstract: NK4 may be a promising agent to inhibit tumor invasion and metastasis. To observe the effects of NK4 on the cardiovascular system with pathological injury and to discuss the mechanism, we established an experimental model of viral myocarditis (VCM) by coxsackievirus B3 infection in Balb/c mice on Day 0 and administered NK4 twice daily to the VCM and control mice from Day 20 to Day 45. We then evaluated the cardiac function by means of ultrasonic inspection. Hepatocyte growth factor, TNF (tumor necrosis factor)-α, and angiotensin II levels in the myocardial tissue were measured with enzyme-linked immunosorbent assay. Myocardium histopathology was examined with hematoxylin and eosin stain. Collagen deposition of the myocardium was detected through Masson staining. Microvessel stai... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951743 Fri, 16 Jan 2009 00:00:00 +0100 2951743 http://www.medworm.com/index.php?rid=3228684&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001324%2Fabstract%3Frss%3Dyes We report a case of intracerebral air embolism after cardiopulmonary resuscitation in a patient with a fatal myocardial infarct. Cases of cerebral air embolism rarely occur as a result of cardiopulmonary resuscitation in cases of cardiopulmonary arrest on arrival. This is the first case with postmortem histological confirmation. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228684 Thu, 15 Jan 2009 00:00:00 +0100 3228684 http://www.medworm.com/index.php?rid=3228675&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001361%2Fabstract%3Frss%3Dyes We present six heart transplant patients with this presentation, two of whom died. The autopsy of one of those patients demonstrated severe rejection of the conduction system, with only mild rejection throughout the rest of the myocardium. We postulate that aggressive therapy for rejection and pacemaker placement may result in improved survival in heart transplant recipients with this clinical presentation. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228675 Thu, 15 Jan 2009 00:00:00 +0100 3228675 http://www.medworm.com/index.php?rid=3228674&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001592%2Fabstract%3Frss%3Dyes Conclusion: Apex pathological analysis provides definite diagnosis and contributes to determine the cases which the cardiac disease have a possibility to recover under VAD. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228674 Thu, 15 Jan 2009 00:00:00 +0100 3228674 http://www.medworm.com/index.php?rid=3228672&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001543%2Fabstract%3Frss%3Dyes Conclusions: FTS is effective in suppressing the progression of EAM and its consequent functional myocardial dysfunction. The effect may be mediated by suppression of the cellular and humoral responses to myosin. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228672 Thu, 15 Jan 2009 00:00:00 +0100 3228672 http://www.medworm.com/index.php?rid=3228670&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001610%2Fabstract%3Frss%3Dyes Abstract: The aim of stereological methods in biomedical research is to obtain quantitative information about three-dimensional (3D) features of tissues, cells, or organelles from two-dimensional physical or optical sections. With immunogold labeling, stereology can even be used for the quantitative analysis of the distribution of molecules within tissues and cells. Nowadays, a large number of design-based stereological methods offer an efficient quantitative approach to intriguing questions in cardiac research, such as “Is there a significant loss of cardiomyocytes during progression from ventricular hypertrophy to heart failure?” or “Does a specific treatment reduce the degree of fibrosis in the heart?” Nevertheless, the use of stereological methods in cardiac research is rare. T... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228670 Thu, 15 Jan 2009 00:00:00 +0100 3228670 http://www.medworm.com/index.php?rid=3057812&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001373%2Fabstract%3Frss%3Dyes Abstract: Granulocyte-colony stimulating factor (G-CSF) mobilizes progenitors from the bone marrow (BM) and into the circulation. In cardiac transplantation, G-CSF pretreatment of both donors and recipients has been found to improve cardiac function. The aim of this study was to examine whether the observed benefit of G-CSF pretreatment in cardiac transplantation involves vascular repopulation by host progenitor cells. Progenitor cells were exposed to immunosuppressive agents±G-CSF. The effect of drug treatment on total cell counts, proliferation, angiogenesis, apoptosis, and tubule formation was assessed. C57BL/6BM-GFP chimeric recipients underwent cardiac transplantation. Host progenitor cell seeding was evaluated on hearts 14 and 30 days post-transplant. G-CSF treatment of BM-derived p... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057812 Thu, 15 Jan 2009 00:00:00 +0100 3057812 http://www.medworm.com/index.php?rid=2951744&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001294%2Fabstract%3Frss%3Dyes Abstract: Background: Because the ubiquitin–proteasome pathway (UPS) is required for activation of nuclear factor kappa beta (NFkB), a transcription factor that regulates inflammatory genes, we evaluated the UPS activity, NFkB activation, and tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, in ischemic specimens of diabetic myocardium and relate them to the glycemic control (HbA1c), oxidative stress (nitrotyrosine, a modified amino acid produced by reactive O2), and cardiac outcome (echocardiographic parameters). Moreover, the role of UPS, NFkB, and TNF-alpha in the cardiac tissue injury of acute ischemia/reperfusion (I/R) was evaluated in streptozotocin (STZ)-hyperglycemic rats. Finally, this study aimed to elucidate whether an intervention on UPS with bortezomib, an... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951744 Thu, 15 Jan 2009 00:00:00 +0100 2951744 http://www.medworm.com/index.php?rid=2763498&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001075%2Fabstract%3Frss%3Dyes Abstract: A case report of aortic dissection (AoD) complicated by a shunt to the right ventricle is presented. Complications, treatment options, and survival of patients with Type A and Type B AoD are reviewed. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763498 Thu, 15 Jan 2009 00:00:00 +0100 2763498 http://www.medworm.com/index.php?rid=2564373&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001300%2Fabstract%3Frss%3Dyes We report an unusual case of adipocitary heart mass that did not fully satisfy the so-far valid criteria for lipomatous hypertrophy of interatrial septum (LHAS) and deviated from the features previous works attributed to LHAS to such a significant extent as to strongly point to the alternative diagnosis of cardiac hibernoma, which would be consistent with data available in the literature. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564373 Thu, 15 Jan 2009 00:00:00 +0100 2564373 http://www.medworm.com/index.php?rid=2115953&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19150246%26dopt%3DAbstract CONCLUSIONS: cLPS is present in arterial disease, and the potential role of C. pneumoniae in the pathogenesis of both peripheral atherosclerosis disease and AAA should not be forgotten. cLPS has a positive correlation with serum inflammatory markers, but this is no proof of a causal association. PMID: 19150246 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2115953 Wed, 14 Jan 2009 05:00:00 +0100 2115953 http://www.medworm.com/index.php?rid=2115952&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19150247%26dopt%3DAbstract Authors: Shen D, Tang Q, Huang Z, Chen Y, Xiong R, Wu H, Huang J, Feng S, Yan L, Bian Z NK4 may be a promising agent to inhibit tumor invasion and metastasis. To observe the effects of NK4 on the cardiovascular system with pathological injury and to discuss the mechanism, we established an experimental model of viral myocarditis (VCM) by coxsackievirus B3 infection in Balb/c mice on Day 0 and administered NK4 twice daily to the VCM and control mice from Day 20 to Day 45. We then evaluated the cardiac function by means of ultrasonic inspection. Hepatocyte growth factor, TNF (tumor necrosis factor)-alpha, and angiotensin II levels in the myocardial tissue were measured with enzyme-linked immunosorbent assay. Myocardium histopathology was examined with hematoxylin and eosin stain. Collage... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2115952 Wed, 14 Jan 2009 05:00:00 +0100 2115952 http://www.medworm.com/index.php?rid=2115951&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19150248%26dopt%3DAbstract We present the case of a 36-year-old woman with widespread metastatic cardiac angiosarcoma to the lungs and the liver. She was treated with preoperative chemotherapy and underwent extensive surgical resection of the cardiac mass and is currently doing well. Analysis of the effectiveness of various treatment modalities from cases which have been reported has also been reviewed and discussed. PMID: 19150248 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2115951 Wed, 14 Jan 2009 05:00:00 +0100 2115951 http://www.medworm.com/index.php?rid=2110731&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144541%26dopt%3DAbstract CONCLUSIONS: CTAVN occurs exclusively in the area of the AV node, tricuspid valve, and inferior atrial septum. These lesions are now believed to be endodermal in origin, although mesothelial origin was earlier proposed. We report herein a case of CTAVN, the first of its kind diagnosed in an explanted heart specimen and only the fourth diagnosed antemortem. PMID: 19144541 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110731 Mon, 12 Jan 2009 05:00:00 +0100 2110731 http://www.medworm.com/index.php?rid=2110730&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144542%26dopt%3DAbstract We report a case of intracerebral air embolism after cardiopulmonary resuscitation in a patient with a fatal myocardial infarct. Cases of cerebral air embolism rarely occur as a result of cardiopulmonary resuscitation in cases of cardiopulmonary arrest on arrival. This is the first case with postmortem histological confirmation. PMID: 19144542 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110730 Mon, 12 Jan 2009 05:00:00 +0100 2110730 http://www.medworm.com/index.php?rid=2110729&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144543%26dopt%3DAbstract CONCLUSIONS: By contributing to the increased inflammation, the UPS overactivity may enhance the risk of complication during myocardial ischemia in diabetic patients. PMID: 19144543 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110729 Mon, 12 Jan 2009 05:00:00 +0100 2110729 http://www.medworm.com/index.php?rid=2110728&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144544%26dopt%3DAbstract Authors: Mühlfeld C, Nyengaard JR, Mayhew TM The aim of stereological methods in biomedical research is to obtain quantitative information about three-dimensional (3D) features of tissues, cells, or organelles from two-dimensional physical or optical sections. With immunogold labeling, stereology can even be used for the quantitative analysis of the distribution of molecules within tissues and cells. Nowadays, a large number of design-based stereological methods offer an efficient quantitative approach to intriguing questions in cardiac research, such as "Is there a significant loss of cardiomyocytes during progression from ventricular hypertrophy to heart failure?" or "Does a specific treatment reduce the degree of fibrosis in the heart?" Nevertheless, the use of stereological me... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110728 Mon, 12 Jan 2009 05:00:00 +0100 2110728 http://www.medworm.com/index.php?rid=2110727&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144545%26dopt%3DAbstract We describe the case of a large cell neuroendocrine carcinoma of the lung with left intra-atrial extension in a patient presenting with a catastrophic nutritional status. PMID: 19144545 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110727 Mon, 12 Jan 2009 05:00:00 +0100 2110727 http://www.medworm.com/index.php?rid=2110726&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144546%26dopt%3DAbstract CONCLUSIONS: FTS is effective in suppressing the progression of EAM and its consequent functional myocardial dysfunction. The effect may be mediated by suppression of the cellular and humoral responses to myosin. PMID: 19144546 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110726 Mon, 12 Jan 2009 05:00:00 +0100 2110726 http://www.medworm.com/index.php?rid=2110725&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144547%26dopt%3DAbstract Authors: Rezai N, Deisher TA, Heine HL, Wang X, Corbel SY, Leung J, Kerjner A, Rossi FM, Podor TJ, McManus BM PMID: 19144547 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110725 Mon, 12 Jan 2009 05:00:00 +0100 2110725 http://www.medworm.com/index.php?rid=2110724&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144548%26dopt%3DAbstract We present six heart transplant patients with this presentation, two of whom died. The autopsy of one of those patients demonstrated severe rejection of the conduction system, with only mild rejection throughout the rest of the myocardium. We postulate that aggressive therapy for rejection and pacemaker placement may result in improved survival in heart transplant recipients with this clinical presentation. PMID: 19144548 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110724 Mon, 12 Jan 2009 05:00:00 +0100 2110724 http://www.medworm.com/index.php?rid=2110723&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144549%26dopt%3DAbstract Authors: Arena V, Valerio L, Capelli A PMID: 19144549 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110723 Mon, 12 Jan 2009 05:00:00 +0100 2110723 http://www.medworm.com/index.php?rid=2110722&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144550%26dopt%3DAbstract CONCLUSION: Apex pathological analysis provides definite diagnosis and contributes to determine the cases which the cardiac disease have a possibility to recover under VAD. PMID: 19144550 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110722 Mon, 12 Jan 2009 05:00:00 +0100 2110722 http://www.medworm.com/index.php?rid=2110721&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144551%26dopt%3DAbstract CONCLUSION: In symptomatic patients with axillary vein compression due to Langer's axillary arch, a resection of the muscle bundle is an effective way of treatment. PMID: 19144551 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110721 Mon, 12 Jan 2009 05:00:00 +0100 2110721 http://www.medworm.com/index.php?rid=2110720&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19144552%26dopt%3DAbstract Authors: Marek D, Němec P, Maderová K, Heřman M, Gwozdzievicz M, Troubil M, Flodr P, Lukl J A case report of aortic dissection (AoD) complicated by a shunt to the right ventricle is presented. Complications, treatment options, and survival of patients with Type A and Type B AoD are reviewed. PMID: 19144552 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2110720 Mon, 12 Jan 2009 05:00:00 +0100 2110720 http://www.medworm.com/index.php?rid=3228683&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001336%2Fabstract%3Frss%3Dyes We present a case of a 76-year-old woman with a Braunwald-Cutter mitral caged-ball valve prosthesis excised after 33 years post implantation due to a paravalvular leak. The valve itself was intact and fully functional. We believe the longevity of this valve was due to the decreased flow velocities and the lower pressure in the mitral valve position. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228683 Fri, 09 Jan 2009 00:00:00 +0100 3228683 http://www.medworm.com/index.php?rid=3228676&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001622%2Fabstract%3Frss%3Dyes Conclusions: Cardiac hemangiomas are rare tumors with a variety of imaging features which may suggest the diagnosis. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228676 Fri, 09 Jan 2009 00:00:00 +0100 3228676 http://www.medworm.com/index.php?rid=3057815&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001348%2Fabstract%3Frss%3Dyes We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO). (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057815 Fri, 09 Jan 2009 00:00:00 +0100 3057815 http://www.medworm.com/index.php?rid=2101153&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19135389%26dopt%3DAbstract We present a case of a 76-year-old woman with a Braunwald-Cutter mitral caged-ball valve prosthesis excised after 33 years post implantation due to a paravalvular leak. The valve itself was intact and fully functional. We believe the longevity of this valve was due to the decreased flow velocities and the lower pressure in the mitral valve position. PMID: 19135389 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2101153 Wed, 07 Jan 2009 05:00:00 +0100 2101153 http://www.medworm.com/index.php?rid=2101152&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19135390%26dopt%3DAbstract CONCLUSIONS: Cardiac hemangiomas are rare tumors with a variety of imaging features which may suggest the diagnosis. PMID: 19135390 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2101152 Wed, 07 Jan 2009 05:00:00 +0100 2101152 http://www.medworm.com/index.php?rid=2101151&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19135391%26dopt%3DAbstract We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO). PMID: 19135391 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2101151 Wed, 07 Jan 2009 05:00:00 +0100 2101151 http://www.medworm.com/index.php?rid=3228681&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001257%2Fabstract%3Frss%3Dyes Abstract: A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228681 Tue, 25 Nov 2008 00:00:00 +0100 3228681 http://www.medworm.com/index.php?rid=2951746&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001221%2Fabstract%3Frss%3Dyes Conclusions: Segmental arterial mediolysis is an acute limited disease. Sequelae recognized radiologically include aneurysms, dissecting hematomas, arterial stenosis, and occlusions. Generally, these persist, become smaller, or resolve, but symptomatic dissections with delayed onset occur. Sequelae of subclinical forms of segmental arterial mediolysis may cause isolated idiopathic aneurysms or may evolve into arterial lesions indistinguishable from fibromuscular dysplasia. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951746 Tue, 25 Nov 2008 00:00:00 +0100 2951746 http://www.medworm.com/index.php?rid=3228682&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001269%2Fabstract%3Frss%3Dyes We describe a patient who underwent mitral valve replacement for rheumatic mitral stenosis and excision of a grossly abnormal, thickened, and enlarged left atrial appendage. Histological examination confirmed the presence of GCM. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228682 Fri, 21 Nov 2008 00:00:00 +0100 3228682 http://www.medworm.com/index.php?rid=3228680&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001245%2Fabstract%3Frss%3Dyes Conclusions: Clinicians should be aware of the possible extravesical complications, albeit rare, of BCG therapy. Therapy should consist of combined medical and surgical management. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228680 Fri, 21 Nov 2008 00:00:00 +0100 3228680 http://www.medworm.com/index.php?rid=3057818&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001233%2Fabstract%3Frss%3Dyes Abstract: A patient with hypertrophic obstructive cardiomyopathy (HOCM) and an unusual right ventricular mural pattern of endocarditis that clinically mimicked a neoplasm is presented. To our knowledge, this is the first report of right ventricular mural endocarditis complicating HOCM. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057818 Fri, 21 Nov 2008 00:00:00 +0100 3057818 http://www.medworm.com/index.php?rid=3057811&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001312%2Fabstract%3Frss%3Dyes Abstract: While the basic pathobiology of myocardial ischemic injury and reperfusion has been determined over the last 50 years, there are important, unresolved, or at least not completely elucidated, issues in the field. These include the relative contributions of different modes of cell injury and death to evolving myocardial infarcts; interactions of phenomena produced by reperfusion, including stunning and preconditioning; and potential new approaches for successfully combining adjuvant therapy with coronary artery opening. A model of myocardial ischemic and reperfusion injury is proposed involving the potential expression of apoptotic and oncotic pathways in the same perturbed cardiomyocytes. Promising new cardioprotective strategies for reducing lethal reperfusion injury are discusse... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057811 Fri, 21 Nov 2008 00:00:00 +0100 3057811 http://www.medworm.com/index.php?rid=2951745&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001270%2Fabstract%3Frss%3Dyes Conclusions: The above-described postmortem coronary angiographic findings are essential for interventional cardiologists and cardiac surgeons. Damage to the LL or SL type of AV node artery may cause severe or limited AV conduction abnormalities, respectively. Furthermore, the course of AV node artery under the CS makes it susceptible to injuries provoked by diagnostic or therapeutic procedures involving the CS area. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951745 Fri, 21 Nov 2008 00:00:00 +0100 2951745 http://www.medworm.com/index.php?rid=1991021&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026575%26dopt%3DAbstract CONCLUSIONS: Segmental arterial mediolysis is an acute limited disease. Sequelae recognized radiologically include aneurysms, dissecting hematomas, arterial stenosis, and occlusions. Generally, these persist, become smaller, or resolve, but symptomatic dissections with delayed onset occur. Sequelae of subclinical forms of segmental arterial mediolysis may cause isolated idiopathic aneurysms or may evolve into arterial lesions indistinguishable from fibromuscular dysplasia. PMID: 19026575 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1991021 Thu, 20 Nov 2008 05:00:00 +0100 1991021 http://www.medworm.com/index.php?rid=1991019&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026577%26dopt%3DAbstract Authors: Pytel P, Husain A, Moskowitz I, Raman J, Macleod H, Anderson AS, Burke M, McNally EM A 41-year-old male with cardiomyopathy from an inherited beta myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart. PMID: 19026577 [PubMed - as s... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1991019 Thu, 20 Nov 2008 05:00:00 +0100 1991019 http://www.medworm.com/index.php?rid=1991025&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026571%26dopt%3DAbstract Authors: Buja LM, Weerasinghe P While the basic pathobiology of myocardial ischemic injury and reperfusion has been determined over the last 50 years, there are important, unresolved, or at least not completely elucidated, issues in the field. These include the relative contributions of different modes of cell injury and death to evolving myocardial infarcts; interactions of phenomena produced by reperfusion, including stunning and preconditioning; and potential new approaches for successfully combining adjuvant therapy with coronary artery opening. A model of myocardial ischemic and reperfusion injury is proposed involving the potential expression of apoptotic and oncotic pathways in the same perturbed cardiomyocytes. Promising new cardioprotective strategies for reducing lethal reper... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1991025 Wed, 19 Nov 2008 05:00:00 +0100 1991025 http://www.medworm.com/index.php?rid=1991024&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026572%26dopt%3DAbstract We describe a patient who underwent mitral valve replacement for rheumatic mitral stenosis and excision of a grossly abnormal, thickened, and enlarged left atrial appendage. Histological examination confirmed the presence of GCM. PMID: 19026572 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1991024 Wed, 19 Nov 2008 05:00:00 +0100 1991024 http://www.medworm.com/index.php?rid=1991023&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026573%26dopt%3DAbstract CONCLUSIONS: Clinicians should be aware of the possible extravesical complications, albeit rare, of BCG therapy. Therapy should consist of combined medical and surgical management. PMID: 19026573 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1991023 Wed, 19 Nov 2008 05:00:00 +0100 1991023 http://www.medworm.com/index.php?rid=1991022&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026574%26dopt%3DAbstract CONCLUSIONS: The above-described postmortem coronary angiographic findings are essential for interventional cardiologists and cardiac surgeons. Damage to the LL or SL type of AV node artery may cause severe or limited AV conduction abnormalities, respectively. Furthermore, the course of AV node artery under the CS makes it susceptible to injuries provoked by diagnostic or therapeutic procedures involving the CS area. PMID: 19026574 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1991022 Wed, 19 Nov 2008 05:00:00 +0100 1991022 http://www.medworm.com/index.php?rid=1991020&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026576%26dopt%3DAbstract Authors: Fyfe B, Ianosi-Irimie M, Motavelli L A patient with hypertrophic obstructive cardiomyopathy (HOCM) and an unusual right ventricular mural pattern of endocarditis that clinically mimicked a neoplasm is presented. To our knowledge, this is the first report of right ventricular mural endocarditis complicating HOCM. PMID: 19026576 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1991020 Wed, 19 Nov 2008 05:00:00 +0100 1991020 http://www.medworm.com/index.php?rid=3057819&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001282%2Fabstract%3Frss%3Dyes Discussion: Although lipomas have benign pathology and slow growth, they warrant surgical excision in view of possible fatal complications. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057819 Mon, 17 Nov 2008 00:00:00 +0100 3057819 http://www.medworm.com/index.php?rid=1969057&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19010061%26dopt%3DAbstract DISCUSSION: Although lipomas have benign pathology and slow growth, they warrant surgical excision in view of possible fatal complications. PMID: 19010061 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1969057 Thu, 13 Nov 2008 05:00:00 +0100 1969057 http://www.medworm.com/index.php?rid=2763494&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000951%2Fabstract%3Frss%3Dyes Conclusion: Adventitial angiogenesis and lymphangiogenesis are induced by intimal inflammation after balloon injury, and these neogenetic vessels in turn promote intimal inflammation and hyperplasia probably via delivery and activation of inflammatory cells. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763494 Sun, 05 Oct 2008 23:00:00 +0100 2763494 http://www.medworm.com/index.php?rid=2763492&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001087%2Fabstract%3Frss%3Dyes Abstract: Introduction: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disorder of the cardiac sarcomere, resulting in myocyte hypertrophy and disarray, interstitial fibrosis, and cardiac dysfunction. Our aim was to determine whether the amount of fibrosis in HCM correlates with echocardiographic measures of diastolic dysfunction, presence of HCM-susceptibility mutations, or polymorphisms in the renin-angiotensin-aldosterone system (RAAS).Methods: Surgical specimens from patients with obstructive HCM undergoing septal myectomy at the Mayo Clinic (2001–2004) were examined and compared with autopsy-derived tissues from age- and sex-matched normal controls. Digital image analysis was used to quantitate the fibrosis in representative microscopic sections. Genotyping was performed for m... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763492 Sun, 05 Oct 2008 23:00:00 +0100 2763492 http://www.medworm.com/index.php?rid=2763497&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000938%2Fabstract%3Frss%3Dyes Conclusions: Real-time RT-PCR was performed on 42 laser microdissected regions of 14 plaques. The expressions of all four genes examined were significantly lower in the medial region at mRNA level. High expressions were noted in both shoulder and neovascular regions, with no significant difference between the two. Furthermore, these expression patterns were related significantly to macrophage infiltration. In conclusion, hypoxia- and thioredoxin-related genes are significantly overexpressed in human stable carotid atherosclerotic plaques and strongly correlate with macrophage infiltration rather than neovascularization. Macrophage infiltration may lead to overexpression of these genes and promote angiogenesis in stable carotid plaques. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763497 Thu, 02 Oct 2008 23:00:00 +0100 2763497 http://www.medworm.com/index.php?rid=3057817&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS105488070800094X%2Fabstract%3Frss%3Dyes We present a 21-week gestation fetus, who upon routine investigation was noted to have a left-sided pleural effusion. The pregnancy was terminated, and at autopsy, a diagnosis of intrapericardial teratoma was confirmed. Primary cardiac tumors in infants and children are rare, and intrapericardial teratomas are even more so. In this brief case report, we review intrapericardial teratomas and present pertinent diagnostic and management options. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057817 Thu, 02 Oct 2008 00:00:00 +0100 3057817 http://www.medworm.com/index.php?rid=3057814&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000963%2Fabstract%3Frss%3Dyes In this report, we illustrate the utility of image techniques for the diagnosis and the monitoring of primary cardiac tumors, especially the role of bone scintigraphy. This technique is not a routine procedure for the cardiologist, but it has been very useful in this case in order to decide the optimal treatment. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057814 Thu, 02 Oct 2008 00:00:00 +0100 3057814 http://www.medworm.com/index.php?rid=3057808&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001099%2Fabstract%3Frss%3Dyes Abstract: The lesion responsible for the overwhelming majority of acute coronary events is plaque disruption or erosion with superimposed thrombosis. The term “vulnerable plaque” has been used to describe those atherosclerotic plaques that are particularly susceptible to disruption. Vulnerable plaques are generally characterized as those having a thin inflamed fibrous cap over a very large lipid core. However, only a small percentage of such plaques rupture, and plaques with different characteristics may also rupture and thrombose. Most autopsy, intravascular ultrasound, and recent computed tomography angiographic studies of coronary arteries reveal large plaques at sites of rupture. While angiographic data are said to show less severe narrowing at sites of plaque rupture, actual revie... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057808 Thu, 02 Oct 2008 00:00:00 +0100 3057808 http://www.medworm.com/index.php?rid=2951747&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001105%2Fabstract%3Frss%3Dyes Conclusions: Our data confirm and extend previous findings of a direct relationship between dysregulation of nitric oxide pathway and atherosclerosis, suggesting another possible mechanism by which nitric oxide synthase system abnormalities may promote vascular dysfunction during human atherogenesis. Changes in nitric oxide production might be the primary step in the development of atheroma. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951747 Thu, 02 Oct 2008 00:00:00 +0100 2951747 http://www.medworm.com/index.php?rid=2763491&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708001063%2Fabstract%3Frss%3Dyes Conclusion: This report demonstrates that increased activity of a single enzyme, MMP-2, within a transgenic context reproduces many of the features of the human MVP syndrome. The cardiac-specific MMP-2 transgenic mouse potentially provides a unique experimental platform for the evaluation of nonsurgical therapies based on the underlying pathophysiology of this disease. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763491 Wed, 01 Oct 2008 23:00:00 +0100 2763491 http://www.medworm.com/index.php?rid=1856206&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835191%26dopt%3DAbstract CONCLUSIONS: Patients with HCM undergoing septal myectomy had significantly more myocardial interstitial fibrosis than controls. The amount of fibrosis in HCM patients correlated with degree of septal hypertrophy and left ventricular systolic and diastolic function. Notably, neither mutations in cardiac myofilament proteins or polymorphisms in RAAS exhibited strong associations with severity of myocardial fibrosis. PMID: 18835191 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856206 Wed, 01 Oct 2008 04:00:00 +0100 1856206 http://www.medworm.com/index.php?rid=1856205&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835192%26dopt%3DAbstract CONCLUSION: Adventitial angiogenesis and lymphangiogenesis are induced by intimal inflammation after balloon injury, and these neogenetic vessels in turn promote intimal inflammation and hyperplasia probably via delivery and activation of inflammatory cells. PMID: 18835192 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856205 Wed, 01 Oct 2008 04:00:00 +0100 1856205 http://www.medworm.com/index.php?rid=1856204&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835788%26dopt%3DAbstract In this report, we illustrate the utility of image techniques for the diagnosis and the monitoring of primary cardiac tumors, especially the role of bone scintigraphy. This technique is not a routine procedure for the cardiologist, but it has been very useful in this case in order to decide the optimal treatment. PMID: 18835788 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856204 Tue, 30 Sep 2008 04:00:00 +0100 1856204 http://www.medworm.com/index.php?rid=1856203&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835789%26dopt%3DAbstract CONCLUSIONS: Our data confirm and extend previous findings of a direct relationship between dysregulation of nitric oxide pathway and atherosclerosis, suggesting another possible mechanism by which nitric oxide synthase system abnormalities may promote vascular dysfunction during human atherogenesis. Changes in nitric oxide production might be the primary step in the development of atheroma. PMID: 18835789 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856203 Tue, 30 Sep 2008 04:00:00 +0100 1856203 http://www.medworm.com/index.php?rid=1856202&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835790%26dopt%3DAbstract CONCLUSION: This report demonstrates that increased activity of a single enzyme, MMP-2, within a transgenic context reproduces many of the features of the human MVP syndrome. The cardiac-specific MMP-2 transgenic mouse potentially provides a unique experimental platform for the evaluation of nonsurgical therapies based on the underlying pathophysiology of this disease. PMID: 18835790 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856202 Tue, 30 Sep 2008 04:00:00 +0100 1856202 http://www.medworm.com/index.php?rid=1856201&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835791%26dopt%3DAbstract We present a 21-week gestation fetus, who upon routine investigation was noted to have a left-sided pleural effusion. The pregnancy was terminated, and at autopsy, a diagnosis of intrapericardial teratoma was confirmed. Primary cardiac tumors in infants and children are rare, and intrapericardial teratomas are even more so. In this brief case report, we review intrapericardial teratomas and present pertinent diagnostic and management options. PMID: 18835791 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856201 Tue, 30 Sep 2008 04:00:00 +0100 1856201 http://www.medworm.com/index.php?rid=1856200&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835792%26dopt%3DAbstract CONCLUSIONS: Real-time RT-PCR was performed on 42 laser microdissected regions of 14 plaques. The expressions of all four genes examined were significantly lower in the medial region at mRNA level. High expressions were noted in both shoulder and neovascular regions, with no significant difference between the two. Furthermore, these expression patterns were related significantly to macrophage infiltration. In conclusion, hypoxia- and thioredoxin-related genes are significantly overexpressed in human stable carotid atherosclerotic plaques and strongly correlate with macrophage infiltration rather than neovascularization. Macrophage infiltration may lead to overexpression of these genes and promote angiogenesis in stable carotid plaques. PMID: 18835792 [PubMed - as supplied by publisher]... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856200 Tue, 30 Sep 2008 04:00:00 +0100 1856200 http://www.medworm.com/index.php?rid=1856199&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18835793%26dopt%3DAbstract Authors: Fishbein MC The lesion responsible for the overwhelming majority of acute coronary events is plaque disruption or erosion with superimposed thrombosis. The term "vulnerable plaque" has been used to describe those atherosclerotic plaques that are particularly susceptible to disruption. Vulnerable plaques are generally characterized as those having a thin inflamed fibrous cap over a very large lipid core. However, only a small percentage of such plaques rupture, and plaques with different characteristics may also rupture and thrombose. Most autopsy, intravascular ultrasound, and recent computed tomography angiographic studies of coronary arteries reveal large plaques at sites of rupture. While angiographic data are said to show less severe narrowing at sites of plaque rupture, a... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1856199 Tue, 30 Sep 2008 04:00:00 +0100 1856199 http://www.medworm.com/index.php?rid=2564369&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000872%2Fabstract%3Frss%3Dyes Conclusions: The study describes the occurrence of DSM in adults. It is important to remember that it can occur following a repair of underlying congenital heart disease. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564369 Sun, 28 Sep 2008 23:00:00 +0100 2564369 http://www.medworm.com/index.php?rid=1844911&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18823798%26dopt%3DAbstract CONCLUSIONS: The study describes the occurrence of DSM in adults. It is important to remember that it can occur following a repair of underlying congenital heart disease. PMID: 18823798 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1844911 Thu, 25 Sep 2008 04:00:00 +0100 1844911 http://www.medworm.com/index.php?rid=2763496&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000884%2Fabstract%3Frss%3Dyes Conclusions: We conclude that histologically AAA could not be classified in analogy to clinical characteristics. We suggest that progression of large AAA is mainly determined by parameters other than histological features of the diseased vessel wall. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763496 Mon, 18 Aug 2008 23:00:00 +0100 2763496 http://www.medworm.com/index.php?rid=2564366&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000641%2Fabstract%3Frss%3Dyes Conclusions: Pathologic findings in left ventricular apical cores have little prognostic utility in guiding patient management as related to overall 1-year mortality, but may indicate patients who are more likely to positively remodel their hearts. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564366 Mon, 18 Aug 2008 23:00:00 +0100 2564366 http://www.medworm.com/index.php?rid=3228677&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000720%2Fabstract%3Frss%3Dyes We report an interesting autopsy observation in patients who received methylene blue as adjunct therapy for septic shock. The exposed surface of cardiac myocardium on both fresh and fixed states rapidly turned green. In the presence of molecular oxygen, the colorless metabolite leukomethylene blue is readily oxidized to methylene blue, thus explaining the visible color change of the myocardium. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3228677 Fri, 15 Aug 2008 00:00:00 +0100 3228677 http://www.medworm.com/index.php?rid=3057816&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000707%2Fabstract%3Frss%3Dyes We report a case of arterial occlusion caused by distal embolization of the suture material in the percutaneous closure device. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=3057816 Fri, 15 Aug 2008 00:00:00 +0100 3057816 http://www.medworm.com/index.php?rid=2763495&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000902%2Fabstract%3Frss%3Dyes Conclusions: Mechanical coaptation of the mitral leaflets in an animal model demonstrates adequate tissue response and healing with complete encapsulation of the device by 12 weeks and ongoing healing response proportional to duration of implantation. Infective endocarditis remains a potential complication in the animal model and for all implanted prosthetic devices. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763495 Thu, 14 Aug 2008 23:00:00 +0100 2763495 http://www.medworm.com/index.php?rid=2564372&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000690%2Fabstract%3Frss%3Dyes This well-illustrated book is co-authored by over 50 contributors, all of whom are experts in the field, from Europe and the United States of America. The book summarizes the major advances in knowledge about ARVD/C in the last 25 years in succinct, well-organized, remarkably illustrated and easy-to-read chapters. Most chapters include original work by each contributor, further strengthening each section and adding to its value. This book provides good, new insight into a condition which is associated with significant mortality in the young. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564372 Thu, 14 Aug 2008 23:00:00 +0100 2564372 http://www.medworm.com/index.php?rid=2564368&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000719%2Fabstract%3Frss%3Dyes Conclusions: Detection of PVIE, especially the isolated type, may be underdiagnosed. This condition should be kept in mind during evaluation of patients especially with cardiac anomalies, who present with fever, prominent respiratory symptoms, and negative blood cultures. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564368 Thu, 14 Aug 2008 23:00:00 +0100 2564368 http://www.medworm.com/index.php?rid=2564367&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000689%2Fabstract%3Frss%3Dyes Conclusions: In our cases, fibromuscular hyperplasia of the pulmonary artery alone might or might not have accounted for the sudden deaths, if it had not been for the concomitant presence of hypoplasia of the arcuate nucleus in the brainstem and/or cardiac conduction system abnormalities. Therefore, they were classified as SIDS/sudden unexpected perinatal death gray zone or borderline cases. Necropsy studies of sudden infant and perinatal death should always include an accurate gross and histological examination of the pulmonary arteries, as well as of the brainstem and cardiac conduction system. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564367 Thu, 14 Aug 2008 23:00:00 +0100 2564367 http://www.medworm.com/index.php?rid=2951750&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS105488070800063X%2Fabstract%3Frss%3Dyes Abstract: We demonstrate a rare case of an atypically located posterior left atrial myxoma from both cardiac imaging and anatomical pathology perspectives. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951750 Thu, 14 Aug 2008 00:00:00 +0100 2951750 http://www.medworm.com/index.php?rid=1717297&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18706832%26dopt%3DAbstract CONCLUSIONS: We conclude that histologically AAA could not be classified in analogy to clinical characteristics. We suggest that progression of large AAA is mainly determined by parameters other than histological features of the diseased vessel wall. PMID: 18706832 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1717297 Wed, 13 Aug 2008 04:00:00 +0100 1717297 http://www.medworm.com/index.php?rid=1717296&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18706833%26dopt%3DAbstract CONCLUSIONS: Pathologic findings in left ventricular apical cores have little prognostic utility in guiding patient management as related to overall 1-year mortality, but may indicate patients who are more likely to positively remodel their hearts. PMID: 18706833 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1717296 Wed, 13 Aug 2008 04:00:00 +0100 1717296 http://www.medworm.com/index.php?rid=1717295&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18706834%26dopt%3DAbstract CONCLUSIONS: Altered expression of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 contributes to atrial extracellular matrix remodeling and atrial dilatation. Angiotensin-II-mediated intracellular Ca(2+) overload may be the mechanism of altered expression of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1. Angiotensin-converting enzyme inhibitor treatment may attenuate atrial structural remodeling by normalizing the balance between matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1. PMID: 18706834 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1717295 Wed, 13 Aug 2008 04:00:00 +0100 1717295 http://www.medworm.com/index.php?rid=1709387&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18703354%26dopt%3DAbstract Authors: Jellis C, Hunter A, Sutton R We demonstrate a rare case of an atypically located posterior left atrial myxoma from both cardiac imaging and anatomical pathology perspectives. PMID: 18703354 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1709387 Tue, 12 Aug 2008 04:00:00 +0100 1709387 http://www.medworm.com/index.php?rid=1709386&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18703355%26dopt%3DAbstract CONCLUSIONS: Detection of PVIE, especially the isolated type, may be underdiagnosed. This condition should be kept in mind during evaluation of patients especially with cardiac anomalies, who present with fever, prominent respiratory symptoms, and negative blood cultures. PMID: 18703355 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1709386 Tue, 12 Aug 2008 04:00:00 +0100 1709386 http://www.medworm.com/index.php?rid=1709385&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18703356%26dopt%3DAbstract CONCLUSIONS: In our cases, fibromuscular hyperplasia of the pulmonary artery alone might or might not have accounted for the sudden deaths, if it had not been for the concomitant presence of hypoplasia of the arcuate nucleus in the brainstem and/or cardiac conduction system abnormalities. Therefore, they were classified as SIDS/sudden unexpected perinatal death gray zone or borderline cases. Necropsy studies of sudden infant and perinatal death should always include an accurate gross and histological examination of the pulmonary arteries, as well as of the brainstem and cardiac conduction system. PMID: 18703356 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1709385 Tue, 12 Aug 2008 04:00:00 +0100 1709385 http://www.medworm.com/index.php?rid=1709384&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18703357%26dopt%3DAbstract We report a case of arterial occlusion caused by distal embolization of the suture material in the percutaneous closure device. PMID: 18703357 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1709384 Tue, 12 Aug 2008 04:00:00 +0100 1709384 http://www.medworm.com/index.php?rid=1709383&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18703358%26dopt%3DAbstract We report an interesting autopsy observation in patients who received methylene blue as adjunct therapy for septic shock. The exposed surface of cardiac myocardium on both fresh and fixed states rapidly turned green. In the presence of molecular oxygen, the colorless metabolite leukomethylene blue is readily oxidized to methylene blue, thus explaining the visible color change of the myocardium. PMID: 18703358 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1709383 Tue, 12 Aug 2008 04:00:00 +0100 1709383 http://www.medworm.com/index.php?rid=1709382&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18703359%26dopt%3DAbstract CONCLUSIONS: Mechanical coaptation of the mitral leaflets in an animal model demonstrates adequate tissue response and healing with complete encapsulation of the device by 12 weeks and ongoing healing response proportional to duration of implantation. Infective endocarditis remains a potential complication in the animal model and for all implanted prosthetic devices. PMID: 18703359 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1709382 Tue, 12 Aug 2008 04:00:00 +0100 1709382 http://www.medworm.com/index.php?rid=1700869&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18692408%26dopt%3DAbstract We report a representative case and review the literature concerning this unusual case of infective endocarditis. PMID: 18692408 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1700869 Thu, 07 Aug 2008 04:00:00 +0100 1700869 http://www.medworm.com/index.php?rid=1700868&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18692409%26dopt%3DAbstract CONCLUSIONS: Continuous subthreshold electrical stimulation to the LSG induces both sympathetic and parasympathetic hyperinnervation in both right and left atria in normal dogs. PMID: 18692409 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1700868 Thu, 07 Aug 2008 04:00:00 +0100 1700868 http://www.medworm.com/index.php?rid=2951748&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000586%2Fabstract%3Frss%3Dyes Conclusions: We diagnosed this tumor as cardiac myxoma with an atypical hypercellular component suggesting a malignant change. It is important to recognize that a cardiac myxoma could be accompanied by atypical change. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2951748 Mon, 14 Jul 2008 00:00:00 +0100 2951748 http://www.medworm.com/index.php?rid=2564365&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000604%2Fabstract%3Frss%3Dyes Conclusions: Amyloid deposits can be reliably subtyped in small diagnostic cardiac specimens using immunofluorescence. The practical aspects of implementing an immunofluorescence approach are compared with those of other approaches for subtyping amyloid in the clinical setting. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564365 Sun, 13 Jul 2008 23:00:00 +0100 2564365 http://www.medworm.com/index.php?rid=2564364&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000598%2Fabstract%3Frss%3Dyes Abstract: We compared the interobserver reproducibility of the 1990 and 2004 International Society for Heart and Lung Transplantation (ISHLT) grading system for cardiac rejection. The 2004 ISHLT grading system for cardiac allograft rejection did not improve reproducibility partly due to pathologists' disagreement in diagnosing Grades 1B/1R and 3A/2R rejection. To achieve better reproducibility, better criteria for defining 1B/1R vs. 3A/2R rejection and markers of myocyte injury are needed. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564364 Sun, 13 Jul 2008 23:00:00 +0100 2564364 http://www.medworm.com/index.php?rid=2564363&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000574%2Fabstract%3Frss%3Dyes Abstract: Introduction: Extracellular matrix changes occur in many heart valve pathologies. For example, myxomatous mitral valves are reported to contain excess proteoglycans and hyaluronan. However, it is unknown which specific proteoglycans are altered in myxomatous valves. Because proteoglycans perform varied functions in connective tissues, this study was designed to identify and localize three matrix-associated proteoglycans, as well as hyaluronan and the hyaluronan receptor for endocytosis, within myxomatous and normal mitral valves.Methods: Human mitral posterior leaflets (control, n=6–9; myxomatous, n=14–21; mean age, 61 years for all groups) were histochemically stained for proteoglycan core proteins, hyaluronan, and the hyaluronan receptor for endocytosis. Stain intensity was... Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2564363 Sun, 13 Jul 2008 23:00:00 +0100 2564363 http://www.medworm.com/index.php?rid=1631244&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18621549%26dopt%3DAbstract CONCLUSION: Excess decorin, biglycan, and versican may be associated with the remodeling of other matrix components in myxomatous mitral valves. Decreased expression of the hyaluronan receptor for endocytosis in myxomatous valves suggests that hyaluronan metabolism could be altered in myxomatous mitral valve disease. These findings contribute towards elucidating the pathogenesis of myxomatous mitral valve disease and developing potential new therapies. PMID: 18621549 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1631244 Fri, 11 Jul 2008 04:00:00 +0100 1631244 http://www.medworm.com/index.php?rid=1631247&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18619857%26dopt%3DAbstract CONCLUSIONS: Amyloid deposits can be reliably subtyped in small diagnostic cardiac specimens using immunofluorescence. The practical aspects of implementing an immunofluorescence approach are compared with those of other approaches for subtyping amyloid in the clinical setting. PMID: 18619857 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1631247 Thu, 10 Jul 2008 04:00:00 +0100 1631247 http://www.medworm.com/index.php?rid=1631246&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18619858%26dopt%3DAbstract CONCLUSIONS: We diagnosed this tumor as cardiac myxoma with an atypical hypercellular component suggesting a malignant change. It is important to recognize that a cardiac myxoma could be accompanied by atypical change. PMID: 18619858 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1631246 Thu, 10 Jul 2008 04:00:00 +0100 1631246 http://www.medworm.com/index.php?rid=1631245&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18619859%26dopt%3DAbstract Authors: Yang HM, Lai CK, Gjertson DW, Baruch-Oren T, Ra SH, Watts W, Wallace WD, Shintaku P, Kobashigawa JA, Fishbein MC We compared the interobserver reproducibility of the 1990 and 2004 International Society for Heart and Lung Transplantation (ISHLT) grading system for cardiac rejection. The 2004 ISHLT grading system for cardiac allograft rejection did not improve reproducibility partly due to pathologists' disagreement in diagnosing Grades 1B/1R and 3A/2R rejection. To achieve better reproducibility, better criteria for defining 1B/1R vs. 3A/2R rejection and markers of myocyte injury are needed. PMID: 18619859 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=1631245 Thu, 10 Jul 2008 04:00:00 +0100 1631245 http://www.medworm.com/index.php?rid=2763499&cid=s_35391_7_f&fid=35391&url=http%3A%2F%2Fwww.cardiovascularpathology.com%2Farticle%2FPIIS1054880708000434%2Fabstract%3Frss%3Dyes This report describes a 45-year-old male patient with nonobstructive hypertrophic cardiomyopathy, biventricular apical aneurysms, and papillary fibroelastoma. Histology revealed muscle fiber disarray, interstitial fibrosis, and mural vessel changes. The wall of the aneurysms showed fat infiltration, and loss and replacement of muscle fibers with fibrous tissues. A review of the literature suggests that this case is the first reported experience with the three pathologies occurring in combination. (Source: Cardiovascular Pathology) Cardiovascular Pathology journals http://www.medworm.com/rss/comments.php?id=2763499 Thu, 29 May 2008 23:00:00 +0100 2763499