Cell Proliferation via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cell Proliferation' source. Sun, 21 Mar 2010 17:33:10 +0100 Oestrogen-related receptor alpha inverse agonist XCT-790 arrests A549 lung cancer cell population growth by inducing mitochondrial reactive oxygen species production http://www.medworm.com/index.php?rid=3311450&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00659.x Conclusions: ERR[alpha] affects cell cycle mechanisms through modulating mitochondrial mass and function. Dysregulation of this essential pathway leads to elevation in mitochondrial ROS production, which in turn modulates activities of tumour suppressors, resulting in cell cycle arrest. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311450 Fri, 26 Feb 2010 16:58:07 +0100 3311450 Recombinant human midkine stimulates proliferation of articular chondrocytes http://www.medworm.com/index.php?rid=3311458&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2010.00668.x Conclusion: Our results demonstrate that rhMK stimulates proliferation of primary articular chondrocytes in vitro and in vivo. The results of this study warrant further examination of rhMK for treatment of animal models of articular cartilage defects. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311458 Fri, 26 Feb 2010 00:00:00 +0100 3311458 Feasibility of using cryopreserved lymphoblastoid cells to diagnose some lysosomal storage diseases http://www.medworm.com/index.php?rid=3311457&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2010.00660.x The Epstein[ndash]Barr virus (EBV) is utilized as a tool in the study of cellular biology because of its capacity to transform B-lymphocytes. For this reason, EBV is used in conservation of human B-lymphocytes for long periods for subsequent evaluation of lysosomal hydrolase activity. Lymphoblastoid cell lines have several advantages for use over other cell types, such as prompt availability and possibility to develop, characterize and standardize cell banks, to test effects of promising pharmaceutical reagents. The study below presents biochemical data that demonstrate validity of lymphoblastoid cell lines for diagnosis of GM1-gangliosidosis, Gaucher, Fabry and Pompe diseases and mucopolysaccharidosis type I. Cultures were prepared from peripheral blood, collected from 25 normal subjects ... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311457 Fri, 26 Feb 2010 00:00:00 +0100 3311457 Establishment and biological characterization of fibroblast cell line from the Langshan chicken http://www.medworm.com/index.php?rid=3311456&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2010.00666.x Conclusion: The cell line met each of the quality control standards required for the American Type Culture Collection. It had not only preserved the genetic resources of the important Langshan chicken at the cellular level, but also provided valuable material for genomic, post-genomic and somatic cell cloning research and other applications. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311456 Fri, 26 Feb 2010 00:00:00 +0100 3311456 γ-secretase inhibitor induces adipogenesis of adipose-derived stem cells by regulation of Notch and PPAR-γ http://www.medworm.com/index.php?rid=3311455&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00661.x Conclusions: We conclude that blocking Notch signalling with DAPT enhances adipogenesis of differentiated mASCs at an early stage. It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-[gamma] activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311455 Fri, 26 Feb 2010 00:00:00 +0100 3311455 Analysis of radiation-induced changes to human melanoma cultures using a mathematical model http://www.medworm.com/index.php?rid=3311454&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2010.00667.x Conclusions: The results, combined with existing data from clonogenic survival assays, support the hypothesis that a dominant effect of radiation in these melanoma lines is the induction of long-term cell cycle arrest. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311454 Fri, 26 Feb 2010 00:00:00 +0100 3311454 Microplate spectrophotometry for high-throughput screening of cytotoxic molecules http://www.medworm.com/index.php?rid=3311453&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00665.x Conclusions: Microplate spectrophotometry is a robust and sensitive method to monitor growth of animal cell populations both in the absence and in the presence of cytotoxic drugs. This method implements existing technologies and can be fully automated. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311453 Fri, 26 Feb 2010 00:00:00 +0100 3311453 Evaluation of Ki-67 and Bcl-2 antigen expression in breast carcinomas of women treated with raloxifene http://www.medworm.com/index.php?rid=3311452&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00664.x Conclusions: Raloxifene treatment significantly reduced Ki-67 antigen expression and increased Bcl-2 expression in breast carcinomas of post-menopausal women. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311452 Fri, 26 Feb 2010 00:00:00 +0100 3311452 3-O-Methylfunicone, a metabolite produced by Penicillium pinophilum, modulates ERK1/2 activity, affecting cell motility of human mesothelioma cells http://www.medworm.com/index.php?rid=3311451&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2010.00663.x Conclusion: OMF may have potential as a naturally derived anti-tumour drug for treatment of mesothelioma. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3311451 Fri, 26 Feb 2010 00:00:00 +0100 3311451 Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells http://www.medworm.com/index.php?rid=3171697&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00662.x Conclusions: Altogether, these data suggest a novel function for apigenin, acting as a suppressor of AKT/PKB pathway in PEL cells, and raise the possibility that this agent may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of the AKT/PKB pathway. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3171697 Thu, 14 Jan 2010 00:00:00 +0100 3171697 Blunting effect of hypoxia on the proliferation and differentiation of human primary and rat L6 myoblasts is not counteracted by Epo http://www.medworm.com/index.php?rid=3124443&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00648.x Conclusions: The data show that exposure to hypoxic conditions (1% O2) of rat and human myoblasts altered their proliferation and differentiation processes. They also show that Epo is not an efficient growth factor to counteract this deleterious effect. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3124443 Mon, 28 Dec 2009 16:15:36 +0100 3124443 DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation http://www.medworm.com/index.php?rid=3124444&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00650.x Conclusions: These results indicate that DNER knockdown in hAMSC accelerated onset of adipogenic differentiation by bypassing mitotic clonal expansion during the early stages of adipogenesis. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3124444 Sun, 27 Dec 2009 00:00:00 +0100 3124444 Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium http://www.medworm.com/index.php?rid=3007905&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00652.x Conclusions: These results suggest that S. typhimurium A1-R monotherapy can effectively treat spinal cord glioma. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3007905 Thu, 19 Nov 2009 00:00:00 +0100 3007905 Sub-millimolar concentration of the novel phenol-based compound, 2-hydroxy benzoate zinc, induces apoptosis in human HT-1080 fibrosarcoma cells http://www.medworm.com/index.php?rid=3003622&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00658.x Conclusions: These results demonstrate that the novel phenolic compound 2HBZ is a potent apoptosis-inducing agent in HT-1080 cells and warrants further investigation as a potential chemotherapeutic agent in primary cancer cell models. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3003622 Wed, 18 Nov 2009 00:00:00 +0100 3003622 The role of scaffold proteins in JNK signalling http://www.medworm.com/index.php?rid=3003625&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00654.x This paper summarises how scaffold proteins affects and regulate the JNK signalling pathway. We believe that some of these scaffold proteins, by virtue of their anchoring and catalytic properties contribute to a high degree of specificity of intra cellular signalling pathways that regulate the progression through the cell cycle. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3003625 Tue, 17 Nov 2009 00:00:00 +0100 3003625 Anti-proliferative effects of γ-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression http://www.medworm.com/index.php?rid=3003624&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00657.x Objectives: Previous studies have shown that [gamma]-tocotrienol induces potent anti-proliferative effects on +SA mammary tumour cells in culture; here, investigations have been conducted to determine its effects on intracellular signalling proteins involved in regulating cell cycle progression.Materials and methods: +SA cells were maintained in mitogen-free defined media containing 0 or 4 [mu]m[gamma]-tocotrienol, for 48 h to synchronize cell cycle in G0 phase, and then they were exposed to 100 ng/ml EGF to initiate cell cycle progression. Whole cell lysates were collected at various time points from each treatment group and were prepared for Western blot analysis.Results and conclusions: Treatment with 4 [mu]m[gamma]-tocotrienol significantly inhibited +SA cell proliferation over a 4-day... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3003624 Tue, 17 Nov 2009 00:00:00 +0100 3003624 Cellular responses and expression profiling of human bone marrow stromal cells stimulated with enamel matrix proteins in vitro http://www.medworm.com/index.php?rid=3003623&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00656.x Conclusions: EMPs promoted cell proliferation and differentiation and gene expression profiles of HBMSCs were affected. This may help elucidation of mechanisms involved in promoting regeneration of periodontal tissues by EMPs. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=3003623 Tue, 17 Nov 2009 00:00:00 +0100 3003623 Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes http://www.medworm.com/index.php?rid=2977107&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00655.x Conclusion: FGF18 seems to play a role in maintenance of chondrocyte properties, although its expression was rather high in dedifferentiated chondrocytes. Upregulation of FGF18 in dedifferentiated chondrocytes implied that it may be a marker of dedifferentiation. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2977107 Tue, 10 Nov 2009 00:00:00 +0100 2977107 Heparin regulates colon cancer cell growth through p38 mitogen-activated protein kinase signalling http://www.medworm.com/index.php?rid=2912056&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00649.x Conclusions: This study demonstrates that an extracellular glycosaminoglycan, heparin, finely modulates expression of genes crucial to cell cycle regulation through specific activation of p38 MAP kinase to stimulate colon cancer cell growth. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2912056 Tue, 20 Oct 2009 23:00:00 +0100 2912056 Expression and role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epithelium http://www.medworm.com/index.php?rid=2912055&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00653.x Conclusions: G0 phase cells with resistance to 5-FU damage expressed Oct3/4, Nanog and Sox2. This indicated that these cells were undifferentiated, but had the ability to terminally differentiate into downstream-type cells. They possessed stem cell properties. The results are consistent with Oct3/4, Nanog and Sox2-expressing cells being considered as tracheal stem cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2912055 Tue, 20 Oct 2009 23:00:00 +0100 2912055 Effect of syndecan-1 overexpression on mesenchymal tumour cell proliferation with focus on different functional domains http://www.medworm.com/index.php?rid=2890460&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00651.x Conclusions: Both full-length and truncated syndecan-1 inhibited proliferation of the mesenchymal tumour cells, providing new insights into the importance for cancer growth of different functional domains of this proteoglycan. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2890460 Tue, 13 Oct 2009 23:00:00 +0100 2890460 The stem cells of small intestinal crypts: where are they? http://www.medworm.com/index.php?rid=2838780&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00642.x Recently, there has been resurgence of interest in the question of small intestinal stem cells, their precise location and numbers in the crypts. In this article, we attempt to re-assess the data, including historical information often omitted in recent studies on the subject. The conclusion we draw is that the evidence supports the concept that active murine small intestinal stem cells in steady state are few in number and are proliferative. There are two evolving, but divergent views on their location (which may be more related to scope of capability and reversibility than to location) several lineage labelling and stem cell self-renewing studies (based on Lgr5 expression) suggest a location intercalated between the Paneth cells (crypt base columnar cells (CBCCs)), or classical cell kine... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2838780 Sun, 27 Sep 2009 23:00:00 +0100 2838780 Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in rats http://www.medworm.com/index.php?rid=2831960&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00641.x Conclusion: Maxy-G34 is a highly potent drug for stimulation of neutrophil production in rats. By our modelling approach, we quantified differences between Maxy-G34 and pegfilgrastim, related to pharmacokinetic parameters. Model simulations can be used to estimate optimal dosing and timing options in the present preclinical rat model. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2831960 Thu, 24 Sep 2009 23:00:00 +0100 2831960 Three clonal types of urothelium with different capacities for replication http://www.medworm.com/index.php?rid=2807422&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00647.x Conclusions: Type-3 cells in the centre of T-III colonies appear to harbour stem-like qualities with a relatively low proliferative and apoptotic index at homeostasis and the ability to become highly proliferative upon passage. This study demonstrates that distinct urothelial cell types with differing clonal capacities can be isolated from the bladder and these cells may have implications for tissue engineering and carcinogenesis. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2807422 Thu, 17 Sep 2009 23:00:00 +0100 2807422 Umbilical cord blood processing using Prepacyte-CB increases haematopoietic progenitor cell availability over conventional Hetastarch separation http://www.medworm.com/index.php?rid=2796297&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00646.x Conclusions: These results show that PrepaCyte-CB offers superior separation of UCB when compared to Hetastarch. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2796297 Mon, 14 Sep 2009 23:00:00 +0100 2796297 ADAM-mediated amphiregulin shedding and EGFR transactivation. http://www.medworm.com/index.php?rid=2772400&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00645.x Conclusion: These findings show that non-transformed and transformed prostate epithelial cells may employ different mechanisms to activate EGFR ligands and thereby utilize the EGFR axis to promote cellular proliferation. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2772400 Sun, 06 Sep 2009 23:00:00 +0100 2772400 Human embryonic stem cells secrete soluble factors that inhibit cancer cell growth http://www.medworm.com/index.php?rid=2757523&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00640.x Conclusions: Our findings provide evidence that the human embryonic microenvironment contains soluble factor(s) that are capable of inhibiting growth of cancer cells, and that exposure to such factors may represent a new cancer treatment strategy. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2757523 Tue, 01 Sep 2009 23:00:00 +0100 2757523 Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/β-catenin pathway http://www.medworm.com/index.php?rid=2733925&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00639.x Conclusion: These results demonstrate that the Wnt/[beta]-catenin pathway is a key modulator of aspirin-induced apoptosis in MSCs by regulation of mitochrondrial/caspase-3 function. More importantly, our findings suggest that aspirin may influence MSC survival under certain conditions; therefore, it should be used with caution when considering regenerative MSC transplantation in patients with concomitant chronic inflammatory diseases such as arthritis. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2733925 Tue, 25 Aug 2009 23:00:00 +0100 2733925 Differential effects of Nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710 http://www.medworm.com/index.php?rid=2733926&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00635.x Conclusion: Our data indicate that NS expression is necessary for cell proliferation and evasion of apoptosis in bladder cancer cells, independent of its effect on p53. Also, we speculate that the precise effect of NS on cell cycle regulation may relate to functional status of RB1 and CDKN2A/p16INK4A. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2733926 Mon, 24 Aug 2009 23:00:00 +0100 2733926 A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaenia http://www.medworm.com/index.php?rid=2708934&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00638.x Conclusion: Dynamics of filgrastim and pegfilgrastim plasma levels can be explained by the same pharmacokinetic model but different model parameters. Beause of a strong clearance mechanism mediated by granulocytes, granulocytotic and granulocytopaenic conditions must be studied simultaneously to construct a reliable model. The pharmacokinetic model will be extended to a murine model of granulopoiesis under chemotherapy and G-CSF application. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2708934 Mon, 17 Aug 2009 23:00:00 +0100 2708934 Ability of the polysaccharide chitosan to inhibit proliferation of CD4+ lymphocytes from mucosal inductive sites, in vitro and in vivo http://www.medworm.com/index.php?rid=2708936&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00634.x Conclusion: Here we demonstrate the ability of chitosan to suppress proliferation of CD4+ lymphocytes from mucosal inductive sites in vivo and in vitro This effect could be relevant in modulatory activity of chitosan in the intestinal microenvironment. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2708936 Sun, 16 Aug 2009 23:00:00 +0100 2708936 Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells http://www.medworm.com/index.php?rid=2708935&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00633.x Conclusion: HDAC activity is essential for maintaining the self-renewal and pluripotency of MSCs. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2708935 Sun, 16 Aug 2009 23:00:00 +0100 2708935 Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers http://www.medworm.com/index.php?rid=2688453&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00636.x Conclusions: Gliocladicillins A (1) and B (2) are effective anti-tumour agents in vitro and in vivo and should be further evaluated for their potential in clinical use. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2688453 Mon, 10 Aug 2009 23:00:00 +0100 2688453 An integrative computational model for intestinal tissue renewal http://www.medworm.com/index.php?rid=2616644&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00627.x Conclusions: We demonstrate that relaxing the assumption that stem-cell positions are fixed enables clonal expansion and niche succession to occur. We also predict that the presence of extracellular factors near the base of the crypt alone suffices to explain the observed spatial variation in nuclear beta-catenin levels along the crypt axis. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2616644 Sun, 19 Jul 2009 23:00:00 +0100 2616644 Hybrid mathematical model of glioma progression http://www.medworm.com/index.php?rid=2610766&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00631.x Conclusions: This model is used to perform multiple simulations to determine sensitivity to changes in important model parameters, specifically, the fundamental length parameter, necrotic cell degradation rate, rate of cell migration, and rate of phenotype transformation. Using these values, the model is able to simulate tumour growth and invasion behaviour, observed clinically. This mathematical model provides a means to simulate various tumour development scenarios, which may lead to a better understanding of how altering fundamental parameters can influence neoplastic progression. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2610766 Thu, 16 Jul 2009 23:00:00 +0100 2610766 Intestinal metaplasia in liver of rats after partial hepatectomy and treatment with acetylaminofluorene http://www.medworm.com/index.php?rid=2610765&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00632.x Conclusion: The existence of this phenotype (along with oval cells and small hepatocyte-like cells) is evidence of multipotency of progenitors involved in the hepatic healing response. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2610765 Thu, 16 Jul 2009 23:00:00 +0100 2610765 Promotion of stem cell proliferation by vegetable peptone http://www.medworm.com/index.php?rid=2601882&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00630.x Conclusions: Our findings revealed that the vegetable peptone promotes proliferation of CB-MSCs and ADSCs. In addition, results of this study suggest that induction of stem cell proliferation by vegetable peptone is likely to be related to its induction of VEGF, TGF-[beta]1, and IL-6 expression. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2601882 Tue, 14 Jul 2009 23:00:00 +0100 2601882 Human immature dental pulp stem cells share key characteristic features with limbal stem cells http://www.medworm.com/index.php?rid=2601883&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00623.x Objectives: Limbal stem cells (LSC) are self-renewing, highly proliferative cells in vitro, which express a set of specific markers and in vivo have the capacity to reconstruct the entire corneal epithelium in cases of ocular surface injury. Currently, LSC transplantation is a commonly used procedure in patients with either uni- or bilateral total limbal stem cells deficiency (TLSCD). Although LSC transplantation holds great promise for patients, several problems need to be overcome. In order to find an alternative source of cells that can partially substitute LSC in cornea epithelium reconstruction, we aimed at investigating whether human immature dental pulp stem cells (hIDPSC) would present similar key characteristics as LSC and whether they could be used for corneal surface reconstruct... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2601883 Mon, 13 Jul 2009 23:00:00 +0100 2601883 Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptors via ERK1/2 signalling pathways http://www.medworm.com/index.php?rid=2598076&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00625.x Objective: In Alzheimer's disease, toxic soluble and insoluble forms of amyloid beta (A[beta]) cause synaptic dysfunction and neuronal loss. Given its potential role in producing a toxic host microenvironment for transplanted donor stem cells, we investigated the interaction between A[beta] and proliferation, survival, and differentiation of bone marrow-derived mesenchymal stem cells (BM-MSC) in culture.Materials and methods: We used BM-MSC that had been isolated from mouse bone marrow and cultured, and we also assessed relevant reaction mechanisms using gene microarray, immunocytochemistry, and inhibitors of potential signalling molecules, such as mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)1/2 and tyrosine protein kinase.Results and conclusions: Int... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2598076 Mon, 13 Jul 2009 23:00:00 +0100 2598076 Experimental analysis and modelling of in vitro proliferation of mesenchymal stem cells http://www.medworm.com/index.php?rid=2588049&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00626.x Objectives: Stem cell therapies based on differentiation of adult or embryonic stem cells into specialized ones appear to be effective for treating several human diseases. This work addresses the mathematical simulation of proliferation kinetics of stem cells.Materials and methods: Sheep bone marrow mesenchymal stem cells (phenotype characterized by flow cytometry analysis) seeded at different initial concentrations in Petri dishes were expanded to confluence. Sigmoid temporal profiles of total counts obtained through classic haemocytometry were quantitatively interpreted by both a phenomenological logistic equation and a novel model based on a one-dimensional, single-staged population balance approach capable of taking into account contact inhibition at confluence. The models' parameters ... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2588049 Thu, 09 Jul 2009 23:00:00 +0100 2588049 Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels http://www.medworm.com/index.php?rid=2588048&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00628.x Conclusions: Our results provide a mechanistic basis for the ability of some PPAR agonists to induce death in NHU cells and demonstrate that apoptosis is mediated via PPAR-independent mechanisms, involving intracellular calcium changes, activation of SOCs and induction of the mitochondrial apoptotic pathway. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2588048 Thu, 09 Jul 2009 23:00:00 +0100 2588048 Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells http://www.medworm.com/index.php?rid=2588053&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00624.x Conclusion: These findings suggest that DCA affects intracellular localization and secretion of HMGB1. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2588053 Wed, 08 Jul 2009 23:00:00 +0100 2588053 Crucial role of the local micro-environment in fate decision of neonatal rat NG2 progenitors http://www.medworm.com/index.php?rid=2588052&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00618.x Conclusions: The neuronal micro-environment provided by the culture of hippocampal slices is potent for induction of neurogenesis from oligodendrocyte NG2+/PDGFR[alpha]+/CNP+ progenitor cells and promotes their differentiation not only into macroglia but also into neurons. It also sustains their proliferative capacity. The results indicate the crucial role of the local cellular environment in fate decision of primary NG2+ multipotent neural progenitor cells, which may affect their behaviour after transplantation into the central nervous system. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2588052 Wed, 08 Jul 2009 23:00:00 +0100 2588052 Transglutaminase down-regulates the dimerization of epidermal growth factor receptor in rat perivenous and periportal hepatocytes http://www.medworm.com/index.php?rid=2588051&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00622.x Conclusion: The present data showed good correlation with our previous data on EGF-induced DNA synthesis and EGFR-binding affinity to EGF. These results suggest that zonal difference in cell growth between PPH and PVH may be caused by down-regulation of EGFR dimerization and subsequent autophosphorylation through TG2-mediated cross-linking of EGFR. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2588051 Wed, 08 Jul 2009 23:00:00 +0100 2588051 Gender differences in pulmonary regenerative response to naphthalene-induced bronchiolar epithelial cell injury http://www.medworm.com/index.php?rid=2588050&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00629.x Conclusions: These findings show that there are clear gender differences in naphthalene-induced lung injury and repair. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2588050 Wed, 08 Jul 2009 23:00:00 +0100 2588050 Corrigendum http://www.medworm.com/index.php?rid=2552855&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00644.x (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2552855 Sun, 28 Jun 2009 23:00:00 +0100 2552855 Erratum http://www.medworm.com/index.php?rid=2552854&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.643_2.x (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2552854 Sun, 28 Jun 2009 23:00:00 +0100 2552854 Erratum http://www.medworm.com/index.php?rid=2552853&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.643_1.x (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2552853 Sun, 28 Jun 2009 23:00:00 +0100 2552853 Erratum http://www.medworm.com/index.php?rid=2552852&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00637.x (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2552852 Sun, 28 Jun 2009 23:00:00 +0100 2552852 Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation http://www.medworm.com/index.php?rid=2552851&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00621.x Conclusions: Our approach provides new insights into organization of MSC populations in vitro. The results suggest that MSC differentiation is largely reversible and that lineage plasticity is restricted to stem cells and early progenitors. The model predicts a significant impact of short-term low oxygen treatment on MSC differentiation and optimal chondrogenic differentiation at 10[ndash]11% pO2. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2552851 Sun, 28 Jun 2009 23:00:00 +0100 2552851 Characterization of brain cancer stem cells: a mathematical approach http://www.medworm.com/index.php?rid=2508699&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00619.x Objective: In recent years, support has increased for the notion that a subpopulation of brain tumour cells in possession of properties typically characteristic of stem cells is responsible for initiating and maintaining the tumour. Unravelling details of the brain tumour stem cell (BTSC) hierarchy, as well as interactions of these cells with various therapies, will be essential in the design of optimal treatment strategies.Materials and methods: Motivated by this, we have developed a mathematical model of the BTSC hypothesis that may aid in characterization of brain tumours, as well as in prediction of effective therapeutic strategies, which can be further validated in experimental and clinical studies. At the level of a small number of cells, the model developed herein is stochastic. For... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508699 Wed, 24 Jun 2009 23:00:00 +0100 2508699 Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation http://www.medworm.com/index.php?rid=2508700&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00612.x Conclusions: Differentiated neurons carrying severely pathogenic mtDNA defects can provide a useful model for understanding how such mutations can cause neuronal dysfunction. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508700 Mon, 22 Jun 2009 23:00:00 +0100 2508700 Effects of ultraviolet radiation on human cutaneous nerve fibres http://www.medworm.com/index.php?rid=2463703&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00620.x Conclusions: Quantification of cell damage induced by UV radiation provides useful information for identification of new skin care compounds with neuroprotective properties. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2463703 Mon, 08 Jun 2009 04:00:00 +0100 2463703 Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietin http://www.medworm.com/index.php?rid=2463702&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00617.x Conclusions: Erythropoietin, at high concentrations, may significantly increase cellular damage in HK-2 cells subjected to oxidative stress, which may be due in part to decrease in activation of important signalling pathways involved in cell survival and/or cell proliferation. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2463702 Mon, 08 Jun 2009 04:00:00 +0100 2463702 Noggin maintains pluripotency of human embryonic stem cells grown on Matrigel http://www.medworm.com/index.php?rid=2457440&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00616.x Conclusion: Noggin can be utilized for short term prevention of spontaneous differentiation of stem cells grown on Matrigel. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2457440 Fri, 05 Jun 2009 04:00:00 +0100 2457440 Impaired in vivo vasculogenic potential of endothelial progenitor cells in comparison to human umbilical vein endothelial cells in a spheroid-based implantation model http://www.medworm.com/index.php?rid=2508705&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00610.x Conclusion: Our results indicate that vascular-derived endothelial cells, such as HUVECs are superior to EPCs in terms of promoting in vivo vascularization of engineered tissues. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508705 Thu, 28 May 2009 23:00:00 +0100 2508705 Isolation and characterization of multipotent stem cells from human cruciate ligaments http://www.medworm.com/index.php?rid=2508704&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00611.x Conclusions: In summary, our study demonstrates that human multipotent stem cells can be isolated and expanded from human ACL and PCL, which are easily obtained from patients following total knee or cruciate ligament reconstructive surgery. Self-renewal and mesodermal differentiation potential of these cells make them a viable alternative source for use in regenerative medicine. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508704 Thu, 28 May 2009 23:00:00 +0100 2508704 Isolation and characterization of stem cells from the human parathyroid gland http://www.medworm.com/index.php?rid=2508703&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00614.x Conclusions: Our results reveal that PDSCs were similar phenotypically to MSCs and further studies are needed to formulate induction conditions to differentiate PDSCs into parathyroid hormone-secreting chief cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508703 Thu, 28 May 2009 23:00:00 +0100 2508703 Effect of raloxifene on vascular endothelial growth factor expression in breast carcinomas of postmenopausal women http://www.medworm.com/index.php?rid=2508702&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00615.x Conclusion: Raloxifene significantly reduced VEGF expression in these oestrogen receptor-positive breast carcinomas of postmenopausal women. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508702 Thu, 28 May 2009 23:00:00 +0100 2508702 Virtual glioblastoma: growth, migration and treatment in a three-dimensional mathematical model http://www.medworm.com/index.php?rid=2508701&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00613.x Conclusions: The model provides a useful initial framework by which biological mechanisms of invasion and efficacy of potential treatment regimens may be assessed. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508701 Thu, 28 May 2009 23:00:00 +0100 2508701 Microtubule-interacting drugs induce moderate and reversible damage to human bone marrow mesenchymal stem cells http://www.medworm.com/index.php?rid=2508708&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00607.x This study aimed to investigate molecular and cellular changes induced in human bone marrow mesenchymal stem cells (hMSCs) after treatment with microtubule-interacting agents and to estimate damage to the bone marrow microenvironment caused by chemotherapy.Materials and methods: Using an in vitro hMSC culture system and biochemical and morphological approaches, we studied the effect of nocodazole and taxol® on microtubule and nuclear envelope organization, tubulin and p53 synthesis, cell cycle progression and proliferation and death of hMSCs isolated from healthy donors.Results and conclusions: Both nocodazole and taxol reduced hMSC proliferation and induced changes in the microtubular network and nuclear envelope morphology and organization. However, they exhibited only a moderate effect... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508708 Thu, 21 May 2009 23:00:00 +0100 2508708 Rapid prototyping of anatomically shaped, tissue-engineered implants for restoring congruent articulating surfaces in small joints http://www.medworm.com/index.php?rid=2508707&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00608.x Conclusions: Anatomically shaped, tissue-engineered constructs with designed mechanical properties and internal pore architectures may offer alternatives for reconstruction or restoration of congruent articulating surfaces in small joints. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508707 Thu, 21 May 2009 23:00:00 +0100 2508707 3-O-methylfunicone, a metabolite of Penicillium pinophilum, inhibits proliferation of human melanoma cells by causing G2 + M arrest and inducing apoptosis http://www.medworm.com/index.php?rid=2508706&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00609.x Conclusions: The results reported here seem to suggest that OMF as a promising molecule to include in strategies for treatment of melanoma. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2508706 Thu, 21 May 2009 23:00:00 +0100 2508706 Are mesenchymal stromal cells from children resistant to apoptosis? http://www.medworm.com/index.php?rid=2375584&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00603.x Conclusions: We conclude that MSC from children retain their functional characteristics throughout serial passages and remain stable under conditions that usually cause apoptosis. These features render MSC, especially those of early passages, optimal candidates for use in clinical applications. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2375584 Tue, 28 Apr 2009 04:00:00 +0100 2375584 Arsenic trioxide suppresses paclitaxel-induced mitotic arrest http://www.medworm.com/index.php?rid=2367401&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00606.x Conclusion: The observations that As2O3 has a negative impact on the cell cycle checkpoint activation by taxol should have significant clinical implications because the efficacy of taxol in the clinics is associated with its ability to induce mitotic arrest and subsequent mitotic catastrophe. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2367401 Sat, 25 Apr 2009 04:00:00 +0100 2367401 Effects of core binding factor α1 or bone morphogenic protein-2 overexpression on osteoblast/cementoblast-related gene expressions in NIH3T3 mouse cells and dental follicle cells http://www.medworm.com/index.php?rid=2367404&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00599.x Conclusions: CBFA1 overexpression up-regulated expression levels of osteoblast/cementoblast-related genes and enhanced in vitro osteogenic differentiation more efficiently than BMP-2 in both NIH3T3 cells and DFCs. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2367404 Fri, 24 Apr 2009 04:00:00 +0100 2367404 In vitro three-dimensional modelling of human ovarian surface epithelial cells http://www.medworm.com/index.php?rid=2367403&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00604.x Conclusions: Physiological and biological features of OSE cells grown in 3D culture more closely resemble characteristics of OSE cells in vivo than when grown by classical 2D approaches. It is likely that establishing in vitro 3D OSE models will lead to greater understanding of the mechanisms of neoplastic transformation in epithelial ovarian cancers. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2367403 Fri, 24 Apr 2009 04:00:00 +0100 2367403 Progenitor cell self-renewal and cyclic neutropenia http://www.medworm.com/index.php?rid=2353587&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00598.x Conclusion: The model is compatible with available experimental data and makes testable predictions. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2353587 Tue, 21 Apr 2009 04:00:00 +0100 2353587 Epithelial stem cell-related alterations in Trichinella spiralis-infected small intestine http://www.medworm.com/index.php?rid=2330395&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00605.x Conclusions: T. spiralis infection promotes an initial increase in small intestinal epithelial proliferation and subsequent cell differentiation along the secretory cell lineage. The resulting increase in numbers of Paneth cells at the crypt base causes the proliferative zone to move up the crypt-villus axis. Further studies are required to determine the significance of an increase in the expression of TGF-[beta] transcripts. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2330395 Fri, 17 Apr 2009 04:00:00 +0100 2330395 Colonic stem cell data are consistent with the immortal model of stem cell division under non-random strand segregation http://www.medworm.com/index.php?rid=2301485&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00600.x Objectives: Colonic stem cells are thought to reside towards the base of crypts of the colon, but their numbers and proliferation mechanisms are not well characterized. A defining property of stem cells is that they are able to divide asymmetrically, but it is not known whether they always divide asymmetrically (immortal model) or whether there are occasional symmetrical divisions (stochastic model). By measuring diversity of methylation patterns in colon crypt samples, a recent study found evidence in favour of the stochastic model, assuming random segregation of stem cell DNA strands during cell division. Here, the effect of preferential segregation of the template strand is considered to be consistent with the 'immortal strand hypothesis', and explore the effect on conclusions of previo... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2301485 Sun, 05 Apr 2009 04:00:00 +0100 2301485 Isolation of stem/progenitor cells from normal lung tissue of adult humans http://www.medworm.com/index.php?rid=2301490&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00594.x Conclusions: Ours is the first study to describe ex vivo expansion of stem/progenitor cells resident in human lung epithelia, and our results suggest that the epithelial[ndash]mesenchymal transition process, still active in a subset of airway cells, may regulate transit of stem/progenitor cells towards epithelial differentiation. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2301490 Tue, 31 Mar 2009 04:00:00 +0100 2301490 HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage http://www.medworm.com/index.php?rid=2301489&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00601.x Conclusions: HIPK2 was found to be involved in cell-cycle regulation dependent on p21Waf-1/Cip-1 and independent of DNA damage. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2301489 Tue, 31 Mar 2009 04:00:00 +0100 2301489 Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery http://www.medworm.com/index.php?rid=2301488&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00602.x Conclusions: In this paradigm, drugs and antibodies with large Bp penetrate faster and deeper into tissues when presented at high concentrations. Threshold dependence of tissue transport on applied surface concentration of paclitaxel and rapamycin may explain threshold dose dependence of in vivo biological efficacy of these drugs. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2301488 Tue, 31 Mar 2009 04:00:00 +0100 2301488 Evaluation of the effect of autologous mesenchymal stem cell injection in a large-animal model of bilateral kidney ischaemia reperfusion injury http://www.medworm.com/index.php?rid=2301487&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00591.x Conclusion: In this unique autologous large-animal model, MSCs did not exhibit reparative or paracrine protective properties. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2301487 Tue, 31 Mar 2009 04:00:00 +0100 2301487 The dynamics of tumour–vasculature interaction suggests low-dose, time-dense anti-angiogenic schedulings http://www.medworm.com/index.php?rid=2301486&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00595.x Conclusions: The role of drug elimination rate and of dose fractionation was investigated, and we show that different schedulings, guaranteeing the same mean value of drug concentration, may exhibit very different long-term responses according to their concentration vs. time profile. For a large class of tumour growth laws, the profiles that approach the constant one are the most effective. This behaviour appears to depend on the 'cooperativity' of the tumour-vasculature interaction and on the functional form of the relationship between tumour growth and vasculature extent. Moreover, we suggest that a therapy approaching constant drug infusion might be advantageous also in the case of cytostatic anti-angiogenic drugs. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2301486 Tue, 31 Mar 2009 04:00:00 +0100 2301486 Oct-4A isoform is expressed in human cord blood-derived CD133 stem cells and differentiated progeny http://www.medworm.com/index.php?rid=2301491&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00593.x Conclusions: Oct-4A, which is associated with self-renewal in embryonic stem cells, neither defines nor confers self-renewal to CD133 stem cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2301491 Wed, 25 Mar 2009 04:00:00 +0100 2301491 A novel view on stem cell development: analysing the shape of cellular genealogies http://www.medworm.com/index.php?rid=2226498&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00586.x Conclusions: Based on statistical analysis of cellular genealogies, we conclude that effects of external variables, such as growth conditions, are imprinted in their topology. Moreover, we demonstrate that it is essential to analyse timing of cell fate-specific changes and of occurrence of cell death events in the divisional context in order to understand the mechanisms of lineage commitment. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2226498 Mon, 02 Mar 2009 05:00:00 +0100 2226498 Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells http://www.medworm.com/index.php?rid=2215427&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00582.x Conclusion: Our results suggest that PKC-[iota] is required for cell survival in both transformed non-malignant prostate RWPE-1 cells and androgen-independent malignant prostate DU-145 cells, whereas suppressing PKC-[iota] lead to apoptosis in DU-145 prostate cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2215427 Thu, 26 Feb 2009 05:00:00 +0100 2215427 Fibroblastic response to treatment with different preparations rich in growth factors http://www.medworm.com/index.php?rid=2215430&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00583.x Conclusions: Optimizing composition and use of platelet-rich products is crucial to enhancing the therapeutic potential of this technology. Our data show that the biological effects of PRGF may depend on concentration of platelets and on the anatomical source of the cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2215430 Tue, 24 Feb 2009 05:00:00 +0100 2215430 Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor κB http://www.medworm.com/index.php?rid=2215429&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00584.x Conclusions: The findings of this study suggest that inhibition of cell-cycle progression is capable of reducing pro-inflammatory responses via down-regulation of NF-[kappa]B. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2215429 Tue, 24 Feb 2009 05:00:00 +0100 2215429 Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells http://www.medworm.com/index.php?rid=2215428&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00592.x Conclusion: TIG1 plays an important role in regulating proliferation and differentiation of ASC. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2215428 Tue, 24 Feb 2009 05:00:00 +0100 2215428 Human immature dental pulp stem cells' contribution to developing mouse embryos: production of human/mouse preterm chimaeras http://www.medworm.com/index.php?rid=2199091&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00578.x Conclusion: hIDPSC showed biological compatibility with the mouse host environment and could survive, proliferate and contribute to the inner cell mass as well as to the trophoblast cell layer after introduction into early mouse embryos (n = 28), which achieved the hatching stage following 24 and 48 h in culture. When transferred to foster mice (n = 5), these blastocysts with hIDPSC (n = 57) yielded embryos (n = 3) and foetuses (n = 6); demonstrating presence of human cells in various organs, such as brain, liver, intestine and hearts, of the human/mouse chimaeras. We verified whether hIDPSC would also be able to differentiate into specific cell types in the mouse environment. Contribution of hIDPSC in at least two types of tissues (muscles and epithelial), was confirmed. We showed that hI... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2199091 Fri, 20 Feb 2009 05:00:00 +0100 2199091 Cell-cycle inhibition and apoptosis induced by curcumin and cisplatin or oxaliplatin in human ovarian carcinoma cells http://www.medworm.com/index.php?rid=2199093&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2009.00585.x Conclusions: The data suggests that curcumin is an interesting natural compound capable of limiting cell proliferation and possibly increasing clinical impact of platinum drugs, in ovarian cancer patients. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2199093 Thu, 19 Feb 2009 05:00:00 +0100 2199093 Chondrocyte proliferation in a new culture system http://www.medworm.com/index.php?rid=2199092&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00580.x Conclusions: Chondrocytes in the co-culture system or in enriched medium showed an increase in proliferation; only when osteoarthritis chondrocytes were cultured in enriched medium would they display a statistically significant increase in their proliferation rate and in their viability. When chondrocytes from the monolayer were analysed, differential mRNA expression of TGF-[beta]1 and IGF-1 was found during all passages, which suggests that these two growth factors might be involved in chondrocyte proliferation. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2199092 Thu, 19 Feb 2009 05:00:00 +0100 2199092 Three-dimensional in vitro cell biology models of ovarian and endometrial cancer http://www.medworm.com/index.php?rid=2190116&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00579.x Conclusion: Establishing 3D models of cancer cell lines is likely to be of value for studying the molecular and biological mechanisms of ovarian/endometrial tumour progression and for testing novel molecular targets for cancer therapy. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2190116 Tue, 17 Feb 2009 05:00:00 +0100 2190116 TGFβ inhibits GM-CSF-induced phosphorylation of ERK and MEK in human myeloid leukaemia cell lines via inhibition of phosphatidylinositol 3-kinase (PI3-k) http://www.medworm.com/index.php?rid=2115054&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00567.x Conclusions: These studies thus indicate that TGF[beta] does not activate the ERK pathway but turns off the GM-CSF-induced ERK signal via inhibition of the PI3-kinase-Akt pathway, in these human laeukemia cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2115054 Tue, 20 Jan 2009 05:45:46 +0100 2115054 Corrigendum http://www.medworm.com/index.php?rid=2115055&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00596.x (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2115055 Wed, 14 Jan 2009 05:00:00 +0100 2115055 Myc down-regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line http://www.medworm.com/index.php?rid=2089257&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00576.x Conclusions: Our results suggest that c-Myc could be considered as a good target for the study of new approaches in anticancer astrocytoma treatment. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2089257 Fri, 09 Jan 2009 05:00:00 +0100 2089257 Capacity of robot handling for Epstein-Barr virus transformation http://www.medworm.com/index.php?rid=2086376&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00568.x Conclusions: Based on these facts, a process of EBV transformation can be modified to fit the requirements of robot handling. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2086376 Thu, 08 Jan 2009 05:00:00 +0100 2086376 Reg IV enhances peritoneal metastasis in gastric carcinomas http://www.medworm.com/index.php?rid=2083473&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00577.x Discussion: Increase of expression and secretion of Reg IV, and levels of BCL-2, BCL-XL,survivin, phosphorylated AKT, and phosphorylated EGFR, and decrease of nitric oxide-induced apoptosis were found in Reg IV-transfectants, whereas those were abrogated in the knockdown cells. In mice models, increased number and size of peritoneal tumors and decreased apoptosis were found in Reg IV-transfectants, whereas those were abrogated by the knockdown cells. Mice survivals were worsened in Reg IV-transfectants-inoculated mice, but were improved in Reg IV-knockdown cell-inoculated mice. Levels of Reg IV protein in peritoneal lavage fluids increased in Reg IV-transfectants inoculated mice, but decreased in Reg IV-knockdown cell inoculated mice. In metastasized human gastric cancers, Reg IV positivit... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2083473 Wed, 07 Jan 2009 05:00:00 +0100 2083473 Conditioned medium from renal tubular epithelial cells initiates differentiation of human mesenchymal stem cells http://www.medworm.com/index.php?rid=2083476&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00572.x Conclusions: Our study shows that conditioned medium from renal tubular epithelial cells provides a convenient source of inductive signals to initiate differentiation of ASC towards epithelial lineage. We deduce that these interactions may play an important role during renal repair mechanisms. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2083476 Tue, 06 Jan 2009 05:00:00 +0100 2083476 Efficient differentiation of insulin-producing cells from skin-derived stem cells http://www.medworm.com/index.php?rid=2083475&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00573.x Conclusions: The findings of this study indicate that SKPs can differentiate into functional IPCs and can provide an abundant source of autologous cells for transplantation. This study also provides strategies to derive autologous islet-replacement tissues from human skin stem cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2083475 Tue, 06 Jan 2009 05:00:00 +0100 2083475 Effects of PI3-k/Akt short hairpin RNA on proliferation, fibronectin production and synthesis of thrombospondin-1 and transforming growth factor-β1 in glomerular mesangial cells induced by sublytic C5b-9 complexes http://www.medworm.com/index.php?rid=2083474&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00575.x Conclusions: These data indicate that sublytic C5b-9 can promote proliferation of GMCs and secretion of fibronectin as well as synthesis of thrombospondin-1 and transforming growth factor-[beta]1. The PI3-k/Akt signal pathway in these reactions, mediated by sublytic C5b-9 complexes, may play at least a partial role. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2083474 Tue, 06 Jan 2009 05:00:00 +0100 2083474 Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation http://www.medworm.com/index.php?rid=2072511&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00571.x Conclusion: Our data, thus, indicate that hypoxic exposure has the capacity to sustain long-term self-renewal of hESCs and that this effect is mediated through activation of Notch. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2072511 Sat, 03 Jan 2009 05:00:00 +0100 2072511 Expression and role of Notch signalling in the regeneration of rat tracheal epithelium http://www.medworm.com/index.php?rid=2072513&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00569.x Conclusions: During tracheal epithelial regeneration, Notch signalling maintains an undifferentiated state and promotes proliferation among a population of tracheal epithelial cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2072513 Tue, 30 Dec 2008 05:00:00 +0100 2072513 Cooperative effect of roscovitine and irradiation targets angiogenesis and induces vascular destabilization in human breast carcinoma http://www.medworm.com/index.php?rid=2072512&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00570.x Angiogenesis is considered as an essential process for tumour development and invasion. Previously, we demonstrated that cyclin-dependent kinase inhibition by roscovitine induces a radiosensitization and a synergistic antitumoral effect in human carcinoma but its effect on the microenvironment and tumour angiogenesis remains unknown. Here, we investigated the effect of the combination roscovitine and ionizing radiation (IR) on normal cells in vitro and on tumour angiogenesis in MDA-MB 231 tumour xenografts. We observed that the combination roscovitine and IR induced a marked reduction of angiogenic hot spot and microvascular density in comparison with IR or roscovitine treatments alone. The Ang-2/Tie-2 ratio was increased in presence of reduced vascular endothelial growth factor level sugg... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2072512 Tue, 30 Dec 2008 05:00:00 +0100 2072512 A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis http://www.medworm.com/index.php?rid=2045348&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00574.x Conclusion: A patient-like model of spinal cord glioma was thus developed, which can be used for the discovery of new agents, including those that inhibit invasion and metastasis of the disease as well as those that prevent paralysis. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=2045348 Thu, 18 Dec 2008 05:00:00 +0100 2045348 Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells http://www.medworm.com/index.php?rid=1888919&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00561.x Conclusions: Our findings provide novel insights into the field of cytotoxic properties of essential oils. This study provided evidence on how cytotoxic activity of the oils is not always related to their major constituents, except for lower activity found in both cell lines for [alpha]-cedrol. Interestingly, [beta]-caryophyllene and linalool exhibited comparable IC50 values to the commercial drug vinblastine on the ACHN cell line. This opens a new field of investigation to discover mechanisms responsible for the observed activity. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1888919 Mon, 20 Oct 2008 04:00:00 +0100 1888919 In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells http://www.medworm.com/index.php?rid=1888920&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00564.x Conclusions: hESC-derived ILC grafts continued to contain cells that were positive for islet endocrine hormones and were shown to be functional by their ability to secrete human C-peptide. Further enrichment and maturation of ILCs could lead to generation of a sufficient source of insulin-producing cells for transplantation into patients with type 1 diabetes. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1888920 Sun, 19 Oct 2008 04:00:00 +0100 1888920 Study of oncogenic transformation in ex vivo expanded mesenchymal cells, from paediatric bone marrow http://www.medworm.com/index.php?rid=1872699&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00559.x Conclusions: These findings suggest that MSCs from bone marrow of children do not have oncogenic properties and, therefore, represent validate candidates for applications in regenerative medicine. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1872699 Tue, 14 Oct 2008 04:00:00 +0100 1872699 Spontaneously immortalized mouse mesothelial cells display characteristics of malignant transformation http://www.medworm.com/index.php?rid=1872700&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00560.x Conclusion: These findings have implications for interpretation of in vitro transformation studies, demonstrating broad similarity between spontaneous and induced genetic changes. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1872700 Mon, 13 Oct 2008 04:00:00 +0100 1872700 Regulation of apoptosis by type III interferons http://www.medworm.com/index.php?rid=1855394&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00558.x Conclusions: We report that the IFN-[lambda]R1 chain of the type III IFN receptor complex possesses an intrinsic ability to trigger apoptosis in cells. Signalling induced through the intracellular domain of IFN-[lambda]R1 resulted in G1/G0 phase cell cycle arrest, phosphatidylserine surfacing and chromosomal DNA fragmentation. Caspase-3, caspase-8 and caspase-9 were activated; however, pancaspase inhibitor Z-VAD-FMK did not prevent apoptosis. In addition, the extent of apoptosis correlated with the level of receptor expression and was associated with prolonged IFN-[lambda] signalling. We also demonstrated that the ability to trigger apoptosis is a unique intrinsic function of all IFN receptors. However, more robust apoptosis was induced by signalling through type III IFN receptor than thro... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1855394 Tue, 07 Oct 2008 04:00:00 +0100 1855394 The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis http://www.medworm.com/index.php?rid=1855396&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00557.x Conclusions: ADAM-12 contributes to enhancing HB-EGF shedding from plasma membranes leading to increased cell proliferation and reduced apoptosis in this bronchial epithelial cell line. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1855396 Mon, 06 Oct 2008 04:00:00 +0100 1855396 Lineage specific composition of cyclin D–CDK4/CDK6–p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin http://www.medworm.com/index.php?rid=1855395&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00556.x Conclusions: We demonstrate that proliferation parameters of differentiating cells correlate with the activity and structure of cyclin A/E[ndash]CDK2 but not of cyclin D[ndash]CDK4/6[ndash]p27 complexes. In an exponentially growing P19 cell population, the cyclin D1[ndash]CDK4 complex is detected, which is replaced by cyclin D2/3[ndash]CDK4/6[ndash]p27 complex following density arrest. During endodermal differentiation kinase-inactive cyclin D2/D3[ndash]CDK4[ndash]p27 complexes are formed. Neural differentiation specifically induces cyclin D1 at the expense of cyclin D3 and results in predominant formation of cyclin D1/D2[ndash]CDK4[ndash]p27 complexes. Differentiation is accompanied by cytoplasmic accumulation of cyclin Ds and CDK4/6, which in neural cells are associated with neural outgr... Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1855395 Mon, 06 Oct 2008 04:00:00 +0100 1855395 Caspase-3 activation as a key factor for HBx-transformed cell death http://www.medworm.com/index.php?rid=1699770&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00550.x Conclusions: Detailed exploitation of the regulators of caspase-3 activation could open the gate for finding an efficient target for development of anticancer therapeutics against HBx-transformed hepatocellular carcinoma. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1699770 Wed, 13 Aug 2008 04:00:00 +0100 1699770 Phosphorylation of pRb by cyclin D kinase is necessary for development of cardiac hypertrophy http://www.medworm.com/index.php?rid=1699771&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00549.x Conclusions: These results indicate that cyclin D-cdk4/6-dependent phosphorylation of pRb and activation of E2F is necessary for hypertrophic growth in cardiomyocytes, whereas cyclin E-cdk2 kinase is not necessary for hypertrophy but regulates endoreplication in these cells. The data support the notion that hypertrophic growth of cardiomyocytes involves a partial progression through the G1 phase of the cell cycle. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1699771 Tue, 12 Aug 2008 04:00:00 +0100 1699771 On-chip non-invasive and label-free cell discrimination by impedance spectroscopy http://www.medworm.com/index.php?rid=1670863&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00548.x Conclusions: These results underline the potential of impedance spectroscopy flow cytometry as a valuable complement to other known cytometers and cell detection systems. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1670863 Fri, 01 Aug 2008 04:00:00 +0100 1670863 In vitro polydeoxyribonucleotide effects on human pre-adipocytes http://www.medworm.com/index.php?rid=1670864&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00547.x Conclusions: PDRN seemed to promote proliferation of human pre-adipocytes at both passages, but cell population growth increased in pre-adipocyte at P16, after 9 days as compared to control. Our data suggest that PDRN could act as a pre-adipocyte growth stimulator. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1670864 Thu, 31 Jul 2008 04:00:00 +0100 1670864 Identification of osteo–adipo progenitor cells in fat tissue http://www.medworm.com/index.php?rid=1614979&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00542.x Conclusions: These experiments suggest that osteoblasts and adipocytes share a common predecessor, the OAP, in murine adipose stromal cells. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1614979 Sun, 13 Jul 2008 04:00:00 +0100 1614979 Proteomic analysis of human bone marrow mesenchymal stem cells transduced with human telomerase reverse transcriptase gene during proliferation http://www.medworm.com/index.php?rid=1614983&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00543.x Conclusions: The results suggest that sustaining levels of prohibitin and p53 expression along with differential expression of proteins in hTERT[ndash]hMSCs provide an insight into lack of transforming activity of hTERT[ndash]hMSCs during cell proliferation. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1614983 Tue, 08 Jul 2008 04:00:00 +0100 1614983 Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl2-induced acute tubular injury http://www.medworm.com/index.php?rid=1614982&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00545.x Conclusion: Haematopoietic lineage marrow cells, but not cloned cultured MSCs, can play a role not only in normal wear-and-tear turnover of renal tubular cells, but also in repair after tubular injury. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1614982 Tue, 08 Jul 2008 04:00:00 +0100 1614982 Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells http://www.medworm.com/index.php?rid=1614981&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00544.x Conclusion: Our in silico and in vitro studies demonstrated that non-excitable endothelial cells respond to stimuli in a complex manner, in which intercellular communication is controlled by physicochemical properties of the stimulus and by the cell microenvironment. Such findings may have profound implications for our understanding of the tight nature of autocrine cell growth control, compensation to stress states and response to altered microenvironment, under pathological conditions. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1614981 Tue, 08 Jul 2008 04:00:00 +0100 1614981 An efficient experimental strategy for mouse embryonic stem cell differentiation and separation of a cytokeratin-19-positive population of insulin-producing cells http://www.medworm.com/index.php?rid=1614980&cid=s_32058_171_f&fid=32058&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2184.2008.00541.x Conclusion: Differentiated CK19+ cells reflect an endocrine precursor cell type of ductal origin, potentially suitable for insulin replacement therapy in diabetes. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1614980 Tue, 08 Jul 2008 04:00:00 +0100 1614980 Interleukin-6 induces proliferation in adult spinal cord-derived neural progenitors via the JAK2/STAT3 pathway with EGF-induced MAPK phosphorylation http://www.medworm.com/index.php?rid=1445381&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00537.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 3, Page 377-392, June 2008. Abstract. Introduction: In a previous study, we observed cell proliferation 3 days after spinal cord injury, and levels of interleukin-6 (IL-6) and epidermal growth factor (EGF) had significantly increased in the region of the injury. Objectives: The ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1445381 Thu, 15 May 2008 06:11:45 +0100 1445381 Applicability of cord blood-derived unrestricted somatic stem cells in tissue engineering concepts http://www.medworm.com/index.php?rid=1395996&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00536.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract.  Objectives: Cell-based tissue engineering concepts are becoming an important therapeutic alternative in the treatment of traumatic or chronic skeletal diseases. Here, we have evaluated cord blood-derived unrestricted somatic stem cells (USSCs) ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1395996 Thu, 24 Apr 2008 18:44:00 +0100 1395996 Interleukin-6 receptor superantagonist Sant7 inhibits TGF-β-induced proliferation of human lung fibroblasts http://www.medworm.com/index.php?rid=1395998&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00538.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract. Objectives: Both interleukin-6 (IL-6) and transforming growth factor-β (TGF-β) are crucially involved in fibrotic events that characterize interstitial lung diseases (ILD). Therefore, the aim of this study was to investigate in primary ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1395998 Thu, 24 Apr 2008 08:25:14 +0100 1395998 Do mesenchymal stem cells play a role in vocal fold fat graft survival? http://www.medworm.com/index.php?rid=1395997&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00533.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract. Objectives: Adipose tissue in vocal fold lipoinjection is currently used to treat patients affected by laryngeal hemiplegia or anatomical defects. The aim of this study has been to evaluate the efficacy of this clinical strategy, by long-term ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1395997 Thu, 24 Apr 2008 08:25:14 +0100 1395997 Clonal aspects of plant cell proliferation and their applications to animal cells and bacteria http://www.medworm.com/index.php?rid=1395999&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00526.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract.  Objectives: Extensive mathematical studies have been made on cell clone development but little has been advanced in the mathematics of small clone formation and virtually no actual data of small clone size has been collected. Materials and ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1395999 Thu, 24 Apr 2008 02:16:03 +0100 1395999 Ratio of Wnt3a to BMP4 doses is critical to their synergistic effects on proliferation of differentiating mouse embryonic stem cells http://www.medworm.com/index.php?rid=1376334&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00535.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract.Objectives: To investigate potential interactions between bone morphogenetic protein (BMP) and Wnt signalling on differentiating mouse embryonic stem cells (mESC). Materials and methods: Mouse embryonic stem cells were cultured with differing ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1376334 Wed, 16 Apr 2008 18:22:52 +0100 1376334 Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells http://www.medworm.com/index.php?rid=1376335&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00529.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract.  Objectives: Polycystin-1 (PC1), a signalling receptor regulating Ca2+-permeable cation channels, is mutated in autosomal dominant polycystic kidney disease, which is typically characterized by increased cell proliferation. However, the precise ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1376335 Wed, 16 Apr 2008 01:11:25 +0100 1376335 Human adipose tissue stromal vascular fraction cells differentiate depending on distinct types of media http://www.medworm.com/index.php?rid=1373051&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00531.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract. Objectives: Angiogenesis, the process of formation of blood vessels, is essential for many physiological as well as pathological processes. It has been shown that human adipose tissue contains a population of non-characterized cells, called ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1373051 Tue, 15 Apr 2008 18:43:51 +0100 1373051 Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration http://www.medworm.com/index.php?rid=1373052&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00532.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract. Objectives: Liver regeneration is attenuated in old age and is substantially slower after 90% than after 70% partial hepatectomy (PH). We have previously demonstrated that the proliferative response to a primary mitogen is intact in aged mice, ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1373052 Mon, 14 Apr 2008 22:02:03 +0100 1373052 β-catenin signalling in mesenchymal islet-derived precursor cells http://www.medworm.com/index.php?rid=1370583&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00527.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract. Objectives: Previously, we characterized human islet-derived precursor cells (hIPCs) as mesenchymal stem cells that migrate out from islets in vitro and can differentiate into functional islet-like structures following proliferative expansion. ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1370583 Mon, 14 Apr 2008 18:32:38 +0100 1370583 Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation http://www.medworm.com/index.php?rid=1359954&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00528.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract. Objectives: The aim of this study was to investigate the antitumour promoting effects and possible mechanisms of action of the most abundant polymeric black tea polyphenols (PBPs 1–5) or thearubigins, in vivo. Materials and methods: Effect of ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1359954 Wed, 09 Apr 2008 18:36:17 +0100 1359954 Cell proliferation, apoptosis and mitochondrial damage in rat B50 neuronal cells after cisplatin treatment http://www.medworm.com/index.php?rid=1355528&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00530.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract.  Objectives:  Cisplatin (cisPt) is used as a chemotherapeutic agent for the treatment of a variety of human tumours; more recently, it has been demonstrated that tumour cell exposure to cisPt ultimately results in apoptosis, but the mechanism by ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1355528 Mon, 07 Apr 2008 18:14:34 +0100 1355528 Spider silk fibres in artificial nerve constructs promote peripheral nerve regeneration http://www.medworm.com/index.php?rid=1345806&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00534.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract. Objective: In our study, we describe the use of spider silk fibres as a new material in nerve tissue engineering, in a 20-mm sciatic nerve defect in rats. Materials and methods: We compared isogenic nerve grafts to vein grafts with spider silk ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1345806 Wed, 02 Apr 2008 18:23:45 +0100 1345806 p21Cip1 expression is increased in ambient oxygen, compared to estimated physiological (5%) levels in rat muscle precursor cell culture http://www.medworm.com/index.php?rid=1293801&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00512.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 193-207, April 2008. Abstract.  Objective: While it is common practice to culture cells in the presence of ambient oxygen (~21% O2), O2 level observed in the physiological environment is often much lower. Previous efforts to culture a variety of different stem cells, ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293801 Tue, 11 Mar 2008 18:14:25 +0100 1293801 Influence of supramammary lymph node extract on in vitro cell proliferation http://www.medworm.com/index.php?rid=1293808&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00521.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 299-309, April 2008. Abstract.  Objectives: Experiments were conducted to evaluate whether or not bovine supramammary lymph node extract (LNE) could support cell proliferation when it was substituted for bovine growth serum (BGS) in cell culture media. Materials and Methods: ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293808 Tue, 11 Mar 2008 09:15:41 +0100 1293808 Human plasma accelerates immortalization of B lymphocytes by Epstein–Barr virus http://www.medworm.com/index.php?rid=1293807&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00513.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 292-298, April 2008. Abstract.  Objective: Serum and plasma contain species-specific factors that modulate cell population growth and function, and that are required for proliferation of most cell cultures. Foetal calf serum (FCS) is the most common source of these growth ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293807 Tue, 11 Mar 2008 09:15:39 +0100 1293807 Establishment of a gastric epithelial progenitor cell line from a transgenic mouse expressing the simian virus 40 large T antigen gene in the parietal cell lineage http://www.medworm.com/index.php?rid=1293809&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00522.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR In this study the gastric mucosa of transgenic mice expressing the simian virus 40 large T antigen gene in the parietal cell lineage is used to establish and characterize a new epithelial progenitor cell line. In these mice, ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293809 Tue, 11 Mar 2008 09:15:37 +0100 1293809 Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases http://www.medworm.com/index.php?rid=1293802&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00517.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 208-229, April 2008. Abstract.  Objective: Platelet-activating factor (PAF) is implicated in pathogenesis of persistent pulmonary hypertension of the neonate (PPHN); PAF is a mitogen for lung fibroblasts. PAF's role in pulmonary vascular smooth muscle cell (PVSMC) ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293802 Tue, 11 Mar 2008 09:15:29 +0100 1293802 Imaging of cell trafficking and metastases of paediatric rhabdomyosarcoma http://www.medworm.com/index.php?rid=1293813&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00520.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 365-374, April 2008. Abstract.  Objective: The aim of this study was to establish a preclinical mouse model to study metastases of paediatric rhabdomyosarcoma at the macroscopic and cellular levels, with different imaging methods. Experimental Design: The alveolar ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293813 Tue, 11 Mar 2008 09:15:27 +0100 1293813 Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways http://www.medworm.com/index.php?rid=1293803&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00516.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR This study examined the effect of arachidonic acid on short-period hypoxia-induced regulation of G1 phase cell-cycle ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293803 Tue, 11 Mar 2008 09:15:25 +0100 1293803 Are progenitor cells pre-programmed for sequential cell cycles not requiring cyclins D and E and activation of Cdk2? http://www.medworm.com/index.php?rid=1293805&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00518.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 265-278, April 2008. Abstract.  Objectives: Based on studies of unicellular organisms or cultured mammalian cells, the generally accepted model of cell-cycle regulation has been developed in which sequential (scheduled) expression of cyclins D, E, A and B and activation of ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293805 Tue, 11 Mar 2008 09:15:22 +0100 1293805 Stromal cell-derived factor-1 promotes bone marrow-derived cells differentiation to cardiomyocyte phenotypes in vitro http://www.medworm.com/index.php?rid=1293811&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00519.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 336-347, April 2008. Abstract.  Objective: Recent studies have demonstrated the potential of bone marrow-derived cells (BMDC) to differentiate into cardiomyocytes. Up-regulation of stromal cell-derived factor-1 (SDF-1), a member of the chemokine CXC subfamily, mediating ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293811 Tue, 11 Mar 2008 09:15:21 +0100 1293811 Conjugated linoleic acids differentially alter polyp number and diameter in the Apcmin/+ mouse model of intestinal cancer http://www.medworm.com/index.php?rid=1293806&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00524.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 279-291, April 2008. Abstract.  Objective: Dietary conjugated linoleic acids (CLA) have had many health benefits claimed for them, including antineoplastic actions. Materials and methods: The effects of the predominant forms of CLA, namely the c9t11 and t10c12 isomers, or a ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293806 Tue, 11 Mar 2008 09:15:20 +0100 1293806 Erratum: Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells http://www.medworm.com/index.php?rid=1293814&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00525.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 375, April 2008. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293814 Tue, 11 Mar 2008 09:15:19 +0100 1293814 Assessment of the potential of progenitor stem cells extracted from human peripheral blood for seeding a novel vascular graft material http://www.medworm.com/index.php?rid=1293810&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00523.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 321-335, April 2008. Abstract.  Objective: A novel nanocomposite has recently been developed based on polyhedral oligomeric silsesquioxane attached by direct reaction onto a urethane segment, as a potential vascular graft material; its trade name is UCL-Nano. The UCL-Nano ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293810 Tue, 11 Mar 2008 09:15:18 +0100 1293810 Transforming growth factor-β1 regulates the fate of cultured spinal cord-derived neural progenitor cells http://www.medworm.com/index.php?rid=1293804&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00514.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 248-264, April 2008. Abstract.  Objectives: We have evaluated the physiological roles of transforming growth factor-β1 (TGF-β1) on differentiation, migration, proliferation and anti-apoptosis characteristics of cultured spinal cord-derived neural progenitor cells. Methods: ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293804 Tue, 11 Mar 2008 09:15:13 +0100 1293804 Collagens, stromal cell-derived factor-1α and basic fibroblast growth factor increase cancer cell invasiveness in a hyaluronan hydrogel http://www.medworm.com/index.php?rid=1293812&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00515.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue 2, Page 348-364, April 2008. Abstract.  Objective: Beyond to control of cell migration, differentiation and proliferation, the extracellular matrix (ECM) also contributes to invasiveness of human cancers. As the roles of hyaluronan (HA) and collagens in this process are still ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1293812 Tue, 11 Mar 2008 09:15:06 +0100 1293812 Stem cells and neurological diseases http://www.medworm.com/index.php?rid=1108143&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00486.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 94-114, February 2008. Abstract. Cells of the central nervous system were once thought to be incapable of regeneration. This dogma has been challenged in the last decade with studies showing new, migrating stem cells in the brain in many rodent injury models and findings of ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108143 Thu, 20 Dec 2007 09:39:55 +0100 1108143 Source of cell injected is a critical factors for short and long engraftment in xeno-transplantation http://www.medworm.com/index.php?rid=1108136&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00481.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR This study aims to investigate engraftment of human cord blood and foetal bone marrow stem cells after in utero transplantation via the intracoelomic route in the sheep. Here, we performed transplantation in 14 single and 1 twin sheep foetuses ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108136 Thu, 20 Dec 2007 09:39:55 +0100 1108136 The therapeutic potential of stem cells in heart disease http://www.medworm.com/index.php?rid=1108145&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00480.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 126-145, February 2008. Abstract. Coronary heart disease and chronic heart failure are common and have an increasing frequency. Although interventional and conventional drug therapy may delay ventricular remodelling, there is no basic therapeutic regime available for ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108145 Thu, 20 Dec 2007 09:39:54 +0100 1108145 Progenitor cells and vascular disease http://www.medworm.com/index.php?rid=1108146&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00488.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 146-164, February 2008. Abstract. Vascular progenitor cells have been the focus of much attention in recent years; both from the point of view of their pathophysiological roles and their potential as therapeutic agents. However, there is as yet no definitive description of ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108146 Thu, 20 Dec 2007 09:39:51 +0100 1108146 Stem cells and genetic disease http://www.medworm.com/index.php?rid=1108142&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00487.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 85-93, February 2008. Abstract. Stem cell research is now a very broad field encompassing cells derived from all stages of life from the embryonic stem cells of the early blastocyst through to the adult stem cells of many tissues of the body. Adult stem cells from a variety ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108142 Thu, 20 Dec 2007 09:39:50 +0100 1108142 The problem of deception in embryonic stem cell research http://www.medworm.com/index.php?rid=1108139&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00492.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 65-70, February 2008. Abstract. The field of embryonic stem cell research has been plagued by exaggeration and misrepresentation, as three major journals have had to retract significant claims about progress in this field. This problem is exacerbated by the politicized ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108139 Thu, 20 Dec 2007 09:39:50 +0100 1108139 Parthenotes as a source of embryonic stem cells http://www.medworm.com/index.php?rid=1108134&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00485.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 20-30, February 2008. Abstract. The derivation and study of human embryonic stem cell lines, despite their potential therapeutic usefulness, raise considerable ethical, religious, legal and political concerns because it inevitably leads to the destruction of viable embryos. ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108134 Thu, 20 Dec 2007 09:39:50 +0100 1108134 General principles regarding the use of adult stem cells http://www.medworm.com/index.php?rid=1108141&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00482.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 78-84, February 2008. Abstract. With only a few, almost inevitable exceptions, biomedical research has developed within the last 50 years under the tutelage of ethical standards of notable precision. In the vast world of scientific investigation, few disciplines can boast of ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108141 Thu, 20 Dec 2007 09:39:49 +0100 1108141 Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34+ cells in patients with chronic liver disease http://www.medworm.com/index.php?rid=1108144&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00491.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 115-125, February 2008. Abstract. Evidence is growing in support of the role of stem cells as an attractive alternative in treatment of liver diseases. Recently, we have demonstrated the feasibility and safety of infusing CD34+ adult stem cells; this was performed on five ... (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108144 Thu, 20 Dec 2007 09:39:48 +0100 1108144 Editorial http://www.medworm.com/index.php?rid=1108131&cid=s_32058_170_f&fid=32058&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1365-2184.2008.00510.x%3Fai%3Duz%26mi%3D4mpuw%26af%3DR Cell Proliferation, Volume 41, Issue s1, Page 1-3, February 2008. (Source: Cell Proliferation) Cell Proliferation journals http://www.medworm.com/rss/comments.php?id=1108131 Thu, 20 Dec 2007 09:39:48 +0100 1108131