MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cell' source. Tue, 07 Feb 2012 08:48:51 +0100 http://www.medworm.com/index.php?rid=5657958&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2812%2900103-1 Takashi Kadowaki, Kohjiro Ueki, Toshimasa Yamauchi, Naoto Kubota. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657958 Fri, 03 Feb 2012 00:00:00 +0100 5657958 http://www.medworm.com/index.php?rid=5657957&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2812%2900094-3 Michael J. Emanuele, Andrew E.H. Elia, Qikai Xu, Claudio R. Thoma, Lior Izhar, Yumei Leng, Ailan Guo, Yi-Ning Chen, John Rush, Paul Wei-Che Hsu, Hsueh-Chi Sherry Yen, Stephen J. Elledge. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657957 Fri, 03 Feb 2012 00:00:00 +0100 5657957 http://www.medworm.com/index.php?rid=5657956&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900012-8 Shalev Itzkovitz, Irene C. Blat, Tyler Jacks, Hans Clevers, Alexander van Oudenaarden. Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigat.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657956 Fri, 03 Feb 2012 00:00:00 +0100 5657956 http://www.medworm.com/index.php?rid=5657955&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901571-6 Xiaohong Xu, Jennifer K. Coats, Cindy F. Yang, Amy Wang, Osama M. Ahmed, Maricruz Alvarado, Tetsuro Izumi, Nirao M. Shah. Sex hormones such as estrogen and testosterone are essential for sexually dimorphic behaviors in vertebrates. However, the hormone-activated molecular mechanisms that control the development and f.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657955 Fri, 03 Feb 2012 00:00:00 +0100 5657955 http://www.medworm.com/index.php?rid=5657954&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900009-8 Hidehiko K. Inagaki, Shlomo Ben-Tabou de-Leon, Allan M. Wong, Smitha Jagadish, Hiroshi Ishimoto, Gilad Barnea, Toshihiro Kitamoto, Richard Axel, David J. Anderson. Behavior cannot be predicted from a “connectome” because the brain contains a chemical “map” of neuromodulation superimposed upon its synaptic connectivity map. Neuromodulation changes how neural .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657954 Fri, 03 Feb 2012 00:00:00 +0100 5657954 http://www.medworm.com/index.php?rid=5657953&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900090-6 We report that glycosylpho.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657953 Fri, 03 Feb 2012 00:00:00 +0100 5657953 http://www.medworm.com/index.php?rid=5657952&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900008-6 Paul A. Dutchak, Takeshi Katafuchi, Angie L. Bookout, Jang Hyun Choi, Ruth T. Yu, David J. Mangelsdorf, Steven A. Kliewer. Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state autocrine fa.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657952 Fri, 03 Feb 2012 00:00:00 +0100 5657952 http://www.medworm.com/index.php?rid=5657951&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900022-0 Eric Lau, Harriet Kluger, Tal Varsano, KiYoung Lee, Immo Scheffler, David L. Rimm, Trey Ideker, Ze'ev A. Ronai. The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determi.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657951 Fri, 03 Feb 2012 00:00:00 +0100 5657951 http://www.medworm.com/index.php?rid=5657950&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900021-9 Xinchao Yu, Marianna Breitman, Jonathan Goldberg. Budding of COPI-coated vesicles from Golgi membranes requires an Arf family G protein and the coatomer complex recruited from cytosol. Arf is also required with coatomer-related clathrin adaptor c.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657950 Fri, 03 Feb 2012 00:00:00 +0100 5657950 http://www.medworm.com/index.php?rid=5657949&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900013-X Liedewij Laan, Nenad Pavin, Julien Husson, Guillaume Romet-Lemonne, Martijn van Duijn, Magdalena Preciado López, Ronald D. Vale, Frank Jülicher, Samara L. Reck-Peterson, Marileen Dogterom. Dynein at the cortex contributes to microtubule-based positioning processes such as spindle positioning during embryonic cell division and centrosome positioning during fibroblast migration. To in.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657949 Fri, 03 Feb 2012 00:00:00 +0100 5657949 http://www.medworm.com/index.php?rid=5657948&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901570-4 Tatsuya Nishino, Kozo Takeuchi, Karen E. Gascoigne, Aussie Suzuki, Tetsuya Hori, Takuji Oyama, Kosuke Morikawa, Iain M. Cheeseman, Tatsuo Fukagawa. The multiprotein kinetochore complex must assemble at a specific site on each chromosome to achieve accurate chromosome segregation. Defining the nature of the DNA-protein interactions that specif.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657948 Fri, 03 Feb 2012 00:00:00 +0100 5657948 http://www.medworm.com/index.php?rid=5657947&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900096-7 Guillaume Junion, Mikhail Spivakov, Charles Girardot, Martina Braun, E. Hilary Gustafson, Ewan Birney, Eileen E.M. Furlong. Cell fate decisions are driven through the integration of inductive signals and tissue-specific transcription factors (TFs), although the details on how this information converges in cis re.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657947 Fri, 03 Feb 2012 00:00:00 +0100 5657947 http://www.medworm.com/index.php?rid=5657946&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900088-8 Yasunobu Arima, Masaya Harada, Daisuke Kamimura, Jin-Haeng Park, Fuminori Kawano, Fiona E. Yull, Tadafumi Kawamoto, Yoichiro Iwakura, Ulrich A.K. Betz, Gabriel Márquez, Timothy S. Blackwell, Yoshinobu Ohira, Toshio Hirano, Masaaki Murakami. Although it is believed that neural activation can affect immune responses, very little is known about the neuroimmune interactions involved, especially the regulators of immune traffic across the.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657946 Fri, 03 Feb 2012 00:00:00 +0100 5657946 http://www.medworm.com/index.php?rid=5657945&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900010-4 David M. Tobin, Francisco J. Roca, Sungwhan F. Oh, Ross McFarland, Thad W. Vickery, John P. Ray, Dennis C. Ko, Yuxia Zou, Nguyen D. Bang, Tran T.H. Chau, Jay C. Vary, Thomas R. Hawn, Sarah J. Dunstan, Jeremy J. Farrar, Guy E. Thwaites, Mary-Claire King, Charles N. Serhan, Lalita Ramakrishnan. Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to Mycobacterium.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657945 Fri, 03 Feb 2012 00:00:00 +0100 5657945 http://www.medworm.com/index.php?rid=5657944&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900030-X Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Haibin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra L. Brown, Myung K. Kim, Michael A. Beaven, Alex B. Burgin, Vincent Manganiello, Jay H. Chung. Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplemen.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657944 Fri, 03 Feb 2012 00:00:00 +0100 5657944 http://www.medworm.com/index.php?rid=5657943&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900020-7 Janet E. Dancey, Philippe L. Bedard, Nicole Onetto, Thomas J. Hudson. Personalized cancer medicine is based on increased knowledge of the cancer mutation repertoire and availability of agents that target altered genes or pathways. Given advances in cancer genetics, .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657943 Fri, 03 Feb 2012 00:00:00 +0100 5657943 http://www.medworm.com/index.php?rid=5657942&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900087-6 Gregg L. Semenza. Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional acti.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657942 Fri, 03 Feb 2012 00:00:00 +0100 5657942 http://www.medworm.com/index.php?rid=5657941&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900086-4 Li Qiang, Domenico Accili. Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657941 Fri, 03 Feb 2012 00:00:00 +0100 5657941 http://www.medworm.com/index.php?rid=5657940&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900089-X Daniel R. Foltz, P. Todd Stukenberg. The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657940 Fri, 03 Feb 2012 00:00:00 +0100 5657940 http://www.medworm.com/index.php?rid=5657939&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900091-8 Kevin J. Tracey. Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a speci.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657939 Fri, 03 Feb 2012 00:00:00 +0100 5657939 http://www.medworm.com/index.php?rid=5657938&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900092-X Ajit Lalvani, Marcel A. Behr, Saranya Sridhar. Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a cr.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657938 Fri, 03 Feb 2012 00:00:00 +0100 5657938 http://www.medworm.com/index.php?rid=5657937&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900098-0 Ruth I. Tennen, Eriko Michishita-Kioi, Katrin F. Chua. Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now sh.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657937 Fri, 03 Feb 2012 00:00:00 +0100 5657937 http://www.medworm.com/index.php?rid=5657936&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900097-9 Cancer cells are now revealing their metabolic secrets with a combination of biochemical approaches and omic-level analyses. This issue's Select highlights articles that begin to clarify how cells.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657936 Fri, 03 Feb 2012 00:00:00 +0100 5657936 http://www.medworm.com/index.php?rid=5657935&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2812%2900095-5 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657935 Fri, 03 Feb 2012 00:00:00 +0100 5657935 http://www.medworm.com/index.php?rid=5657934&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900011-6 Wenyu Luo, Amita Sehgal. Although molecular components of the circadian clock are known, mechanisms that transmit signals from the clock and produce rhythmic behavior are poorly understood. We find that the microRNA mi.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5657934 Thu, 02 Feb 2012 00:00:00 +0100 5657934 http://www.medworm.com/index.php?rid=5636806&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900005-0 Amitabha Majumdar, Wanda Colón Cesario, Erica White-Grindley, Huoqing Jiang, Fengzhen Ren, Mohammed “Repon” Khan, Liying Li, Edward Man-Lik Choi, Kasthuri Kannan, Fengli Guo, Jay Unruh, Brian Slaughter, Kausik Si. A long-standing question in the study of long-term memory is how a memory trace persists for years when the proteins that initiated the process turn over and disappear within days. Previously, we .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5636806 Thu, 26 Jan 2012 00:00:00 +0100 5636806 http://www.medworm.com/index.php?rid=5618286&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2812%2900019-0 Wouter H. Moolenaar, Timothy Hla. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618286 Fri, 20 Jan 2012 00:00:00 +0100 5618286 http://www.medworm.com/index.php?rid=5618285&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2812%2900015-3 Sebastian Guettler, Jose LaRose, Evangelia Petsalaki, Gerald Gish, Andy Scotter, Tony Pawson, Robert Rottapel, Frank Sicheri. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618285 Fri, 20 Jan 2012 00:00:00 +0100 5618285 http://www.medworm.com/index.php?rid=5618284&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901514-5 Hiroshi Haeno, Mithat Gonen, Meghan B. Davis, Joseph M. Herman, Christine A. Iacobuzio-Donahue, Franziska Michor. Pancreatic cancer is a leading cause of cancer-related death, largely due to metastatic dissemination. We investigated pancreatic cancer progression by utilizing a mathematical framework of metast.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618284 Fri, 20 Jan 2012 00:00:00 +0100 5618284 http://www.medworm.com/index.php?rid=5618283&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901369-9 Andrew D. Rhim, Emily T. Mirek, Nicole M. Aiello, Anirban Maitra, Jennifer M. Bailey, Florencia McAllister, Maximilian Reichert, Gregory L. Beatty, Anil K. Rustgi, Robert H. Vonderheide, Steven D. Leach, Ben Z. Stanger. Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitiv.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618283 Fri, 20 Jan 2012 00:00:00 +0100 5618283 http://www.medworm.com/index.php?rid=5618282&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901572-8 Wei-Chung Chiang, Tsui-Ting Ching, Hee Chul Lee, Carol Mousigian, Ao-Lin Hsu. Extended longevity is often correlated with increased resistance against various stressors. Insulin/IGF-1-like signaling (IIS) is known to have a conserved role in aging and cellular mechanisms ag.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618282 Fri, 20 Jan 2012 00:00:00 +0100 5618282 http://www.medworm.com/index.php?rid=5618281&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901504-2 Tingting Cui-Wang, Cyril Hanus, Tao Cui, Thomas Helton, Jennifer Bourne, Deborah Watson, Kristen M. Harris, Michael D. Ehlers. Following synthesis, integral membrane proteins dwell in the endoplasmic reticulum (ER) for variable periods that are typically rate limiting for plasma membrane delivery. In neurons, the ER exten.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618281 Fri, 20 Jan 2012 00:00:00 +0100 5618281 http://www.medworm.com/index.php?rid=5618280&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901506-6 Yichang Jia, John C. Mu, Susan L. Ackerman. Although uridine-rich small nuclear RNAs (U-snRNAs) are essential for pre-mRNA splicing, little is known regarding their function in the regulation of alternative splicing or of the biological con.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618280 Fri, 20 Jan 2012 00:00:00 +0100 5618280 http://www.medworm.com/index.php?rid=5618279&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901360-2 Nikolaos Balaskas, Ana Ribeiro, Jasmina Panovska, Eric Dessaud, Noriaki Sasai, Karen M. Page, James Briscoe, Vanessa Ribes. Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues. In the vertebrate neural tube, Son.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618279 Fri, 20 Jan 2012 00:00:00 +0100 5618279 http://www.medworm.com/index.php?rid=5618278&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901569-8 William A. Freed-Pastor, Hideaki Mizuno, Xi Zhao, Anita Langerød, Sung-Hwan Moon, Ruth Rodriguez-Barrueco, Anthony Barsotti, Agustin Chicas, Wencheng Li, Alla Polotskaia, Mina J. Bissell, Timothy F. Osborne, Bin Tian, Scott W. Lowe, Jose M. Silva, Anne-Lise Børresen-Dale, Arnold J. Levine, Jill Bargonetti, Carol Prives. p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We employed a three-dimensional culture model in which nonmalignant breast .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618278 Fri, 20 Jan 2012 00:00:00 +0100 5618278 http://www.medworm.com/index.php?rid=5618277&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901421-8 Zhigao Wang, Hui Jiang, She Chen, Fenghe Du, Xiaodong Wang. The programmed necrosis induced by TNF-α requires the activities of the receptor-interacting serine-threonine kinases RIP1 and RIP3 and their interaction with the mixed lineage kinase domain-like .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618277 Fri, 20 Jan 2012 00:00:00 +0100 5618277 http://www.medworm.com/index.php?rid=5618276&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901422-X Liming Sun, Huayi Wang, Zhigao Wang, Sudan He, She Chen, Daohong Liao, Lai Wang, Jiacong Yan, Weilong Liu, Xiaoguang Lei, Xiaodong Wang. The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety of physiolog.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618276 Fri, 20 Jan 2012 00:00:00 +0100 5618276 http://www.medworm.com/index.php?rid=5618275&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901364-X Souvik Bhattacharjee, Robert V. Stahelin, Kaye D. Speicher, David W. Speicher, Kasturi Haldar. Hundreds of effector proteins of the human malaria parasite Plasmodium falciparum constitute a “secretome” carrying a host-targeting (HT) signal, which predicts their export from the intrac.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618275 Fri, 20 Jan 2012 00:00:00 +0100 5618275 http://www.medworm.com/index.php?rid=5618274&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901366-3 Koshi Kunimoto, Yuji Yamazaki, Tomoki Nishida, Kyosuke Shinohara, Hiroaki Ishikawa, Toshiaki Hasegawa, Takeshi Okanoue, Hiroshi Hamada, Tetsuo Noda, Atsushi Tamura, Shoichiro Tsukita, Sachiko Tsukita. Coordinated beating of cilia in the trachea generates a directional flow of mucus required to clear the airways. Each cilium originates from a barrel-shaped basal body, from the side of which prot.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618274 Fri, 20 Jan 2012 00:00:00 +0100 5618274 http://www.medworm.com/index.php?rid=5618273&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901363-8 Andrew R. Houk, Alexandra Jilkine, Cecile O. Mejean, Rostislav Boltyanskiy, Eric R. Dufresne, Sigurd B. Angenent, Steven J. Altschuler, Lani F. Wu, Orion D. Weiner. Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618273 Fri, 20 Jan 2012 00:00:00 +0100 5618273 http://www.medworm.com/index.php?rid=5618272&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901367-5 Juan L. Mendoza, André Schmidt, Qin Li, Emmanuel Nuvaga, Tyler Barrett, Robert J. Bridges, Andrew P. Feranchak, Chad A. Brautigam, Philip J. Thomas. Misfolding of ΔF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR) underlies pathology in most CF patients. F508 resides in the first nucleotide-binding domain (NBD1) of CFTR near.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618272 Fri, 20 Jan 2012 00:00:00 +0100 5618272 http://www.medworm.com/index.php?rid=5618271&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901368-7 Wael M. Rabeh, Florian Bossard, Haijin Xu, Tsukasa Okiyoneda, Miklos Bagdany, Cory M. Mulvihill, Kai Du, Salvatore di Bernardo, Yuhong Liu, Lars Konermann, Ariel Roldan, Gergely L. Lukacs. The folding and misfolding mechanism of multidomain proteins remains poorly understood. Although thermodynamic instability of the first nucleotide-binding domain (NBD1) of ΔF508 CFTR (cystic fibro.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618271 Fri, 20 Jan 2012 00:00:00 +0100 5618271 http://www.medworm.com/index.php?rid=5618270&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901361-4 Clarissa J. Nobile, Emily P. Fox, Jeniel E. Nett, Trevor R. Sorrells, Quinn M. Mitrovich, Aaron D. Hernday, Brian B. Tuch, David R. Andes, Alexander D. Johnson. A biofilm is an organized, resilient group of microbes in which individual cells acquire properties, such as drug resistance, that are distinct from those observed in suspension cultures. Here, we.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618270 Fri, 20 Jan 2012 00:00:00 +0100 5618270 http://www.medworm.com/index.php?rid=5618269&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901443-7 Pierre Rocheteau, Barbara Gayraud-Morel, Irene Siegl-Cachedenier, Maria A. Blasco, Shahragim Tajbakhsh. Satellite cells are adult skeletal muscle stem cells that are quiescent and constitute a poorly defined heterogeneous population. Using transgenic Tg:Pax7-nGFP mice, we show that Pax7-nGFP (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618269 Fri, 20 Jan 2012 00:00:00 +0100 5618269 http://www.medworm.com/index.php?rid=5618268&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901515-7 Simon R.V. Knott, Jared M. Peace, A. Zachary Ostrow, Yan Gan, Alexandra E. Rex, Christopher J. Viggiani, Simon Tavaré, Oscar M. Aparicio. The replication of eukaryotic chromosomes is organized temporally and spatially within the nucleus through epigenetic regulation of replication origin function. The characteristic initiation timin.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618268 Fri, 20 Jan 2012 00:00:00 +0100 5618268 http://www.medworm.com/index.php?rid=5618267&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901517-0 Guoliang Li, Xiaoan Ruan, Raymond K. Auerbach, Kuljeet Singh Sandhu, Meizhen Zheng, Ping Wang, Huay Mei Poh, Yufen Goh, Joanne Lim, Jingyao Zhang, Hui Shan Sim, Su Qin Peh, Fabianus Hendriyan Mulawadi, Chin Thing Ong, Yuriy L. Orlov, Shuzhen Hong, Zhizhuo Zhang, Steve Landt, Debasish Raha, Ghia Euskirchen, Chia-Lin Wei, Weihong Ge, Huaien Wang, Carrie Davis, Katherine I. Fisher-Aylor, Ali Mortazavi, Mark Gerstein, Thomas Gingeras, Barbara Wold, Yi Sun, Melissa J. Fullwood, Edwin Cheung, Edison Liu, Wing-Kin Sung, Michael Snyder, Yijun Ruan. Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), w.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618267 Fri, 20 Jan 2012 00:00:00 +0100 5618267 http://www.medworm.com/index.php?rid=5618266&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901371-7 Zhaoyu Li, Geetu Tuteja, Jonathan Schug, Klaus H. Kaestner. Hepatocellular carcinoma (HCC) is sexually dimorphic in both rodents and humans, with significantly higher incidence in males, an effect that is dependent on sex hormones. The molecular mechanisms.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618266 Fri, 20 Jan 2012 00:00:00 +0100 5618266 http://www.medworm.com/index.php?rid=5618265&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901516-9 Tobias Rausch, David T.W. Jones, Marc Zapatka, Adrian M. Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A. Northcott, Elke Pfaff, Jelena Tica, Qi Wang, Luca Massimi, Hendrik Witt, Sebastian Bender, Sabrina Pleier, Huriye Cin, Cynthia Hawkins, Christian Beck, Andreas von Deimling, Volkmar Hans, Benedikt Brors, Roland Eils, Wolfram Scheurlen, Jonathon Blake, Vladimir Benes, Andreas E. Kulozik, Olaf Witt, Dianna Martin, Cindy Zhang, Rinnat Porat, Diana M. Merino, Jonathan Wasserman, Nada Jabado, Adam Fontebasso, Lars Bullinger, Frank G. Rücker, Konstanze Döhner, Hartmut Döhner, Jan Koster, Jan J. Molenaar, Rogier Versteeg, Marcel Kool, Uri Tabori, David Malkin, Andrey Korshunov, Michael D. Taylor, Peter Lichter, Stefan M. Pfister, Jan O... Cell journals http://www.medworm.com/rss/comments.php?id=5618265 Fri, 20 Jan 2012 00:00:00 +0100 5618265 http://www.medworm.com/index.php?rid=5618264&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900004-9 Thomas A. Rando, Howard Y. Chang. The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618264 Fri, 20 Jan 2012 00:00:00 +0100 5618264 http://www.medworm.com/index.php?rid=5618263&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900003-7 Kai Kretzschmar, Fiona M. Watt. Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19th century, lineage tracing is n.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618263 Fri, 20 Jan 2012 00:00:00 +0100 5618263 http://www.medworm.com/index.php?rid=5618262&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900007-4 Christopher A. Maher, Richard K. Wilson. The unprecedented resolution of high-throughput genomics has enabled the recent discovery of a phenomenon by which specific regions of the genome are shattered and then stitched together via a sin.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618262 Fri, 20 Jan 2012 00:00:00 +0100 5618262 http://www.medworm.com/index.php?rid=5618261&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900002-5 Sayako Katada, Axel Imhof, Paolo Sassone-Corsi. Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent stu.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618261 Fri, 20 Jan 2012 00:00:00 +0100 5618261 http://www.medworm.com/index.php?rid=5618260&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901574-1 David A. Tuveson, John P. Neoptolemos. Although metastasis is a major cause of morbidity and mortality in patients with pancreatic cancer, the requisite events are currently unknown. In this issue of Cell, Haeno et al. and Rhim .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618260 Fri, 20 Jan 2012 00:00:00 +0100 5618260 http://www.medworm.com/index.php?rid=5618259&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901573-X Francis Ka-Ming Chan, Eric H. Baehrecke. Programmed necrosis has long been recognized as a crucial component of animal development; however, the signaling pathway beyond the protein kinases RIP1 and RIP3 remains largely unknown. Sun et a.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618259 Fri, 20 Jan 2012 00:00:00 +0100 5618259 http://www.medworm.com/index.php?rid=5618258&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900006-2 Colin Macilwain. Biomedical research budgets are frozen or falling in developed countries. Can expansion in developing nations continue as economic contagion spreads? (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618258 Fri, 20 Jan 2012 00:00:00 +0100 5618258 http://www.medworm.com/index.php?rid=5618257&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2812%2900017-7 Emilie, Elena, Robert, Karen, Lara, Faby, Michaeleen, Niki, C. Kara, L. Kara, Rosy. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618257 Fri, 20 Jan 2012 00:00:00 +0100 5618257 http://www.medworm.com/index.php?rid=5618256&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900018-9 2011 was a blockbuster year for the stem cell field. Researchers made great progress in growing complex organs in vitro and producing a variety of cell types on demand. But in the last few months,.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618256 Fri, 20 Jan 2012 00:00:00 +0100 5618256 http://www.medworm.com/index.php?rid=5618255&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2812%2900014-1 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618255 Fri, 20 Jan 2012 00:00:00 +0100 5618255 http://www.medworm.com/index.php?rid=5618254&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2812%2900016-5 Tom Sexton, Eitan Yaffe, Ephraim Kenigsberg, Frédéric Bantignies, Benjamin Leblanc, Michael Hoichman, Hugues Parrinello, Amos Tanay, Giacomo Cavalli. Chromosomes are the physical realization of genetic information and thus form the basis for its readout and propagation. Here we present a high-resolution chromosomal contact map derived from a mo.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5618254 Thu, 19 Jan 2012 00:00:00 +0100 5618254 http://www.medworm.com/index.php?rid=5595086&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901507-8 Dominic Schmidt, Petra C. Schwalie, Michael D. Wilson, Benoit Ballester, Ângela Gonçalves, Claudia Kutter, Gordon D. Brown, Aileen Marshall, Paul Flicek, Duncan T. Odom. CTCF-binding locations represent regulatory sequences that are highly constrained over the course of evolution. To gain insight into how these DNA elements are conserved and spread through the gen.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5595086 Thu, 12 Jan 2012 00:00:00 +0100 5595086 http://www.medworm.com/index.php?rid=5570499&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901568-6 Alan Trounson, Uta Grieshammer. In this issue, Tachibana et al. report the generation of the first chimeras from a nonhuman primate, the rhesus monkey. Unlike mice, rhesus chimeras fail to form when embryonic stem cells are inje.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5570499 Thu, 05 Jan 2012 00:00:00 +0100 5570499 http://www.medworm.com/index.php?rid=5570498&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901508-X Masahito Tachibana, Michelle Sparman, Cathy Ramsey, Hong Ma, Hyo-Sang Lee, Maria Cecilia T. Penedo, Shoukhrat Mitalipov. Totipotent cells in early embryos are progenitors of all stem cells and are capable of developing into a whole organism, including extraembryonic tissues such as placenta. Pluripotent cells in the.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5570498 Thu, 05 Jan 2012 00:00:00 +0100 5570498 http://www.medworm.com/index.php?rid=5570497&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901444-9 Wen Cai Zhang, Ng Shyh-Chang, He Yang, Amit Rai, Shivshankar Umashankar, Siming Ma, Boon Seng Soh, Li Li Sun, Bee Choo Tai, Min En Nga, Kishore Kumar Bhakoo, Senthil Raja Jayapal, Massimo Nichane, Qiang Yu, Dokeu A. Ahmed, Christie Tan, Wong Poo Sing, John Tam, Agasthian Thirugananam, Monireh Soroush Noghabi, Yin Huei Pang, Haw Siang Ang, Paul Robson, Philipp Kaldis, Ross Andrew Soo, Sanjay Swarup, Elaine Hsuen Lim, Bing Lim. Identification of the factors critical to the tumor-initiating cell (TIC) state may open new avenues in cancer therapy. Here we show that the metabolic enzyme glycine decarboxylase (GLDC) is criti.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5570497 Thu, 05 Jan 2012 00:00:00 +0100 5570497 http://www.medworm.com/index.php?rid=5550791&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901510-8 Einat Segev, Yoav Smith, Sigal Ben-Yehuda. Upon starvation, the bacterium Bacillus subtilis enters the process of sporulation, lasting several hours and culminating in formation of a spore, the most resilient cell type known. We sho.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5550791 Thu, 29 Dec 2011 00:00:00 +0100 5550791 http://www.medworm.com/index.php?rid=5535415&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901518-2 Michaeleen Doucleff, Mandy Luk, Andrew Tang. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535415 Fri, 23 Dec 2011 00:00:00 +0100 5535415 http://www.medworm.com/index.php?rid=5535414&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901439-5 Yaron Fuchs, Hermann Steller. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535414 Fri, 23 Dec 2011 00:00:00 +0100 5535414 http://www.medworm.com/index.php?rid=5535413&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901511-X Roberto Chiarle, Yu Zhang, Richard L. Frock, Susanna M. Lewis, Benoit Molinie, Yu-Jui Ho, Darienne R. Myers, Vivian W. Choi, Mara Compagno, Daniel J. Malkin, Donna Neuberg, Stefano Monti, Cosmas C. Giallourakis, Monica Gostissa, Frederick W. Alt. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535413 Fri, 23 Dec 2011 00:00:00 +0100 5535413 http://www.medworm.com/index.php?rid=5535412&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901448-6 Oren Ram, Alon Goren, Ido Amit, Noam Shoresh, Nir Yosef, Jason Ernst, Manolis Kellis, Melissa Gymrek, Robbyn Issner, Michael Coyne, Timothy Durham, Xiaolan Zhang, Julie Donaghey, Charles B. Epstein, Aviv Regev, Bradley E. Bernstein. Hundreds of chromatin regulators (CRs) control chromatin structure and function by catalyzing and binding histone modifications, yet the rules governing these key processes remain obscure. Here, w.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535412 Fri, 23 Dec 2011 00:00:00 +0100 5535412 http://www.medworm.com/index.php?rid=5535411&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901372-9 Lishi Li, Michael Rutlin, Victoria E. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, Michael P. Jankowski, Wenqin Luo, Nathaniel Heintz, H. Richard Koerber, C. Jeffery Woodbury, David D. Ginty. Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic label.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535411 Fri, 23 Dec 2011 00:00:00 +0100 5535411 http://www.medworm.com/index.php?rid=5535410&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901373-0 Takatoshi Iijima, Karen Wu, Harald Witte, Yoko Hanno-Iijima, Timo Glatter, Stéphane Richard, Peter Scheiffele. The assembly of synapses and neuronal circuits relies on an array of molecular recognition events and their modification by neuronal activity. Neurexins are a highly polymorphic family of synaptic.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535410 Fri, 23 Dec 2011 00:00:00 +0100 5535410 http://www.medworm.com/index.php?rid=5535409&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901435-8 Bama Charan Mondal, Tina Mukherjee, Lolitika Mandal, Cory J. Evans, Sergey A. Sinenko, Julian A. Martinez-Agosto, Utpal Banerjee. Maintenance of a hematopoietic progenitor population requires extensive interaction with cells within a microenvironment or niche. In the Drosophila hematopoietic organ, niche-derived Hedge.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535409 Fri, 23 Dec 2011 00:00:00 +0100 5535409 http://www.medworm.com/index.php?rid=5535408&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901442-5 Sichen Shao, Ramanujan S. Hegde. Metazoans secrete an extensive array of small proteins essential for intercellular communication, defense, and physiologic regulation. Their synthesis takes mere seconds, leaving minimal time for .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535408 Fri, 23 Dec 2011 00:00:00 +0100 5535408 http://www.medworm.com/index.php?rid=5535407&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901362-6 Kimberly A. Reynolds, Richard N. McLaughlin, Rama Ranganathan. Recent work indicates a general architecture for proteins in which sparse networks of physically contiguous and coevolving amino acids underlie basic aspects of structure and function. These netwo.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535407 Fri, 23 Dec 2011 00:00:00 +0100 5535407 http://www.medworm.com/index.php?rid=5535406&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901436-X Jaspreet S. Khurana, Jie Wang, Jia Xu, Birgit S. Koppetsch, Travis C. Thomson, Anetta Nowosielska, Chengjian Li, Phillip D. Zamore, Zhiping Weng, William E. Theurkauf. Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasi.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535406 Fri, 23 Dec 2011 00:00:00 +0100 5535406 http://www.medworm.com/index.php?rid=5535405&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901450-4 Igor Ulitsky, Alena Shkumatava, Calvin H. Jan, Hazel Sive, David P. Bartel. Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535405 Fri, 23 Dec 2011 00:00:00 +0100 5535405 http://www.medworm.com/index.php?rid=5535404&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901423-1 We report that nodal TGF-β signals use the poised histone mark H3K9me3.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535404 Fri, 23 Dec 2011 00:00:00 +0100 5535404 http://www.medworm.com/index.php?rid=5535403&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901449-8 Ozlem Yildirim, Ruowang Li, Jui-Hung Hung, Poshen B. Chen, Xianjun Dong, Ly-Sha Ee, Zhiping Weng, Oliver J. Rando, Thomas G. Fazzio. Numerous chromatin regulators are required for embryonic stem (ES) cell self-renewal and pluripotency, but few have been studied in detail. Here, we examine the roles of several chromatin regulato.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535403 Fri, 23 Dec 2011 00:00:00 +0100 5535403 http://www.medworm.com/index.php?rid=5535402&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901445-0 Tatjana Trcek, Daniel R. Larson, Alberto Moldón, Charles C. Query, Robert H. Singer. Messenger RNA decay measurements are typically performed on a population of cells. However, this approach cannot reveal sufficient complexity to provide information on mechanisms that may regulate.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535402 Fri, 23 Dec 2011 00:00:00 +0100 5535402 http://www.medworm.com/index.php?rid=5535401&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901503-0 Almog Bregman, Moran Avraham-Kelbert, Oren Barkai, Lea Duek, Adi Guterman, Mordechai Choder. Promoters are DNA elements that enable transcription and its regulation by trans-acting factors. Here, we demonstrate that yeast promoters can also regulate mRNA decay after the mRNA leaves.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535401 Fri, 23 Dec 2011 00:00:00 +0100 5535401 http://www.medworm.com/index.php?rid=5535400&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901502-9 Feng Zhang, Johannes Vierock, Ofer Yizhar, Lief E. Fenno, Satoshi Tsunoda, Arash Kianianmomeni, Matthias Prigge, Andre Berndt, John Cushman, Jürgen Polle, Jon Magnuson, Peter Hegemann, Karl Deisseroth. The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparallele.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535400 Fri, 23 Dec 2011 00:00:00 +0100 5535400 http://www.medworm.com/index.php?rid=5535399&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901505-4 Claudia Z. Han, Kodi S. Ravichandran. Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phago.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535399 Fri, 23 Dec 2011 00:00:00 +0100 5535399 http://www.medworm.com/index.php?rid=5535398&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901499-1 Mia T. Levine, Harmit S. Malik. Piwi-interacting RNAs (piRNAs) help defend host genomes against germline transposons. In this issue of Cell, Khurana et al. show how alterations in the piRNA-encoding loci within a single g.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535398 Fri, 23 Dec 2011 00:00:00 +0100 5535398 http://www.medworm.com/index.php?rid=5535397&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901500-5 Vivian Bellofatto, Jeffrey Wilusz. The level of an mRNA within a cell depends on both its rate of synthesis and rate of decay. Now, independent studies by Bregman et al. and Trcek et al. provide evidence that these two processes ar.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535397 Fri, 23 Dec 2011 00:00:00 +0100 5535397 http://www.medworm.com/index.php?rid=5535396&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901446-2 Liam J. Drew, Rene Hen. Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535396 Fri, 23 Dec 2011 00:00:00 +0100 5535396 http://www.medworm.com/index.php?rid=5535395&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901509-1 Aseem Z. Ansari, Marsha Rich Rosner, Julius Adler. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535395 Fri, 23 Dec 2011 00:00:00 +0100 5535395 http://www.medworm.com/index.php?rid=5535394&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901501-7 Ignacio Rubio-Somoza, Detlef Weigel, José-Manuel Franco-Zorilla, Juan Antonio García, Javier Paz-Ares. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535394 Fri, 23 Dec 2011 00:00:00 +0100 5535394 http://www.medworm.com/index.php?rid=5535393&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901513-3 In response to cold, the body stimulates brown fat to produce heat. This issue's Select explores recent insights into the molecular and cellular processes that will keep you warm this winter and t.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535393 Fri, 23 Dec 2011 00:00:00 +0100 5535393 http://www.medworm.com/index.php?rid=5535392&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901512-1 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5535392 Fri, 23 Dec 2011 00:00:00 +0100 5535392 http://www.medworm.com/index.php?rid=5513623&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901447-4 Shunji Nakano, Bruce Stillman, H. Robert Horvitz. Although replication-coupled chromatin assembly is known to be important for the maintenance of patterns of gene expression through sequential cell divisions, the role of replication-coupled chrom.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5513623 Thu, 15 Dec 2011 00:00:00 +0100 5513623 http://www.medworm.com/index.php?rid=5484815&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901428-0 Sandeep Kumar, Gregg Duester. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484815 Fri, 09 Dec 2011 00:00:00 +0100 5484815 http://www.medworm.com/index.php?rid=5484814&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901438-3 Marcus C. Stensmyr, Bill S. Hansson. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484814 Fri, 09 Dec 2011 00:00:00 +0100 5484814 http://www.medworm.com/index.php?rid=5484813&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901351-1 Ho Sung Rhee, B. Franklin Pugh. Chromatin immunoprecipitation (ChIP-chip and ChIP-seq) assays identify where proteins bind throughout a genome. However, DNA contamination and DNA fragmentation heterogeneity produce false positiv.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484813 Fri, 09 Dec 2011 00:00:00 +0100 5484813 http://www.medworm.com/index.php?rid=5484812&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901352-3 Rose Loughlin, Jeremy D. Wilbur, Francis J. McNally, François J. Nédélec, Rebecca Heald. Bipolar spindles must separate chromosomes by the appropriate distance during cell division, but mechanisms determining spindle length are poorly understood. Based on a 2D model of meiotic spindle.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484812 Fri, 09 Dec 2011 00:00:00 +0100 5484812 http://www.medworm.com/index.php?rid=5484811&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901375-4 Ping Jun Zhu, Wei Huang, Djanenkhodja Kalikulov, Jong W. Yoo, Andon N. Placzek, Loredana Stoica, Hongyi Zhou, John C. Bell, Michael J. Friedlander, Krešimir Krnjević, Jeffrey L. Noebels, Mauro Costa-Mattioli. The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484811 Fri, 09 Dec 2011 00:00:00 +0100 5484811 http://www.medworm.com/index.php?rid=5484810&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901336-5 Elias Pavlopoulos, Pierre Trifilieff, Vivien Chevaleyre, Luana Fioriti, Sakellarios Zairis, Andrew Pagano, Gaël Malleret, Eric R. Kandel. The cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a regulator of local protein synthesis, is the mouse homolog of ApCPEB, a functional prion protein in Aplysia. Here, we pr.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484810 Fri, 09 Dec 2011 00:00:00 +0100 5484810 http://www.medworm.com/index.php?rid=5484809&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901359-6 Ignacio Cebrian, Geraldine Visentin, Nicolas Blanchard, Mabel Jouve, Alexandre Bobard, Catarina Moita, Jost Enninga, Luis F. Moita, Sebastian Amigorena, Ariel Savina. Antigen (Ag) crosspresentation by dendritic cells (DCs) involves the presentation of internalized Ags on MHC class I molecules to initiate CD8+ T cell-mediated immunity in response to certain path.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484809 Fri, 09 Dec 2011 00:00:00 +0100 5484809 http://www.medworm.com/index.php?rid=5484808&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901350-X Sebastian Guettler, Jose LaRose, Evangelia Petsalaki, Gerald Gish, Andy Scotter, Tony Pawson, Robert Rottapel, Frank Sicheri. The poly(ADP-ribose)polymerases Tankyrase 1/2 (TNKS/TNKS2) catalyze the covalent linkage of ADP-ribose polymer chains onto target proteins, regulating their ubiquitylation, stability, and function.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484808 Fri, 09 Dec 2011 00:00:00 +0100 5484808 http://www.medworm.com/index.php?rid=5484807&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901349-3 Noam Levaot, Oleksandr Voytyuk, Ioannis Dimitriou, Fabrice Sircoulomb, Arun Chandrakumar, Marcel Deckert, Paul M. Krzyzanowski, Andrew Scotter, Shengqing Gu, Salima Janmohamed, Feng Cong, Paul D. Simoncic, Yasuyoshi Ueki, Jose La Rose, Robert Rottapel. Cherubism is an autosomal-dominant syndrome characterized by inflammatory destructive bony lesions resulting in symmetrical deformities of the facial bones. Cherubism is caused by mutations in .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484807 Fri, 09 Dec 2011 00:00:00 +0100 5484807 http://www.medworm.com/index.php?rid=5484806&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901358-4 Jorge Z. Torres, Matthew K. Summers, David Peterson, Matthew J. Brauer, James Lee, Silvia Senese, Ankur A. Gholkar, Yu-Chen Lo, Xingye Lei, Kenneth Jung, David C. Anderson, David P. Davis, Lisa Belmont, Peter K. Jackson. During cell division, cells form the microtubule-based mitotic spindle, a highly specialized and dynamic structure that mediates proper chromosome transmission to daughter cells. Cancer cells can .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484806 Fri, 09 Dec 2011 00:00:00 +0100 5484806 http://www.medworm.com/index.php?rid=5484805&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901348-1 Eugene Oh, Annemarie H. Becker, Arzu Sandikci, Damon Huber, Rachna Chaba, Felix Gloge, Robert J. Nichols, Athanasios Typas, Carol A. Gross, Günter Kramer, Jonathan S. Weissman, Bernd Bukau. As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting, and folding factors. Here, we present a selective ribosome profiling strategy that enables global mon.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484805 Fri, 09 Dec 2011 00:00:00 +0100 5484805 http://www.medworm.com/index.php?rid=5484804&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901335-3 Phillippa C. Taberlay, Theresa K. Kelly, Chun-Chi Liu, Jueng Soo You, Daniel D. De Carvalho, Tina B. Miranda, Xianghong J. Zhou, Gangning Liang, Peter A. Jones. Key regulatory genes, suppressed by Polycomb and H3K27me3, become active during normal differentiation and induced reprogramming. Using the well-characterized enhancer/promoter pair of MYOD1 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484804 Fri, 09 Dec 2011 00:00:00 +0100 5484804 http://www.medworm.com/index.php?rid=5484803&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901370-5 Matthew Slattery, Todd Riley, Peng Liu, Namiko Abe, Pilar Gomez-Alcala, Iris Dror, Tianyin Zhou, Remo Rohs, Barry Honig, Harmen J. Bussemaker, Richard S. Mann. Members of transcription factor families typically have similar DNA binding specificities yet execute unique functions in vivo. Transcription factors often bind DNA as multiprotein complexes, rais.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484803 Fri, 09 Dec 2011 00:00:00 +0100 5484803 http://www.medworm.com/index.php?rid=5484802&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901347-X Maria Hatziapostolou, Christos Polytarchou, Eleni Aggelidou, Alexandra Drakaki, George A. Poultsides, Savina A. Jaeger, Hisanobu Ogata, Michael Karin, Kevin Struhl, Margarita Hadzopoulou-Cladaras, Dimitrios Iliopoulos. Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484802 Fri, 09 Dec 2011 00:00:00 +0100 5484802 http://www.medworm.com/index.php?rid=5484801&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901365-1 Junjie Hu, William A. Prinz, Tom A. Rapoport. How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are sha.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484801 Fri, 09 Dec 2011 00:00:00 +0100 5484801 http://www.medworm.com/index.php?rid=5484800&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901433-4 Simone Reber, Anthony A. Hyman. Although the parts list is nearly complete for many cellular structures, mechanisms that control their size remain poorly understood. Loughlin and colleagues now show that phosphorylation of a sin.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484800 Fri, 09 Dec 2011 00:00:00 +0100 5484800 http://www.medworm.com/index.php?rid=5484799&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901429-2 Agnes D. Berendsen, Bjorn R. Olsen. Cherubism, a case of bone remodeling gone haywire, is associated with mutations in the adaptor protein SH3BP2. Two papers in this issue of Cell (Guettler et al. and Levaot et al.) demonstra.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484799 Fri, 09 Dec 2011 00:00:00 +0100 5484799 http://www.medworm.com/index.php?rid=5484798&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901440-1 Aseem Z. Ansari, Kimberly J. Peterson-Kaufman. Hox transcription factors bind highly related DNA sequences in vitro, yet they regulate different genes and play distinct roles in anterior-posterior patterning in animals. Slattery et al. report .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484798 Fri, 09 Dec 2011 00:00:00 +0100 5484798 http://www.medworm.com/index.php?rid=5484797&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901427-9 Xin Liu, David A. Bushnell, Roger D. Kornberg. How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484797 Fri, 09 Dec 2011 00:00:00 +0100 5484797 http://www.medworm.com/index.php?rid=5484796&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901434-6 Antonio Lanzavecchia, Federica Sallusto. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484796 Fri, 09 Dec 2011 00:00:00 +0100 5484796 http://www.medworm.com/index.php?rid=5484795&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901430-9 William E. Paul. The Nobel Prize in Physiology or Medicine for 2011 to Jules Hoffmann, Bruce Beutler, and the late Ralph Steinman recognizes accomplishments in understanding and unifying the two strands of immunol.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484795 Fri, 09 Dec 2011 00:00:00 +0100 5484795 http://www.medworm.com/index.php?rid=5484794&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901431-0 Gayathri Vaidyanathan. Densely populated areas in rural China require constant vigilance and state-of-the-art technology to stop new pandemics in their tracks. Hurdles are not only scientific in some parts of the develo.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484794 Fri, 09 Dec 2011 00:00:00 +0100 5484794 http://www.medworm.com/index.php?rid=5484793&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901432-2 Sarah K. Bronson, Michael F. Verderame, Ralph L. Keil. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484793 Fri, 09 Dec 2011 00:00:00 +0100 5484793 http://www.medworm.com/index.php?rid=5484792&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901437-1 Outnumbering our own cells by ten to one, the secret lives of our microbiota are beginning to reveal themselves through genomic analyses. This issue's Select features recent studies that begin to .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484792 Fri, 09 Dec 2011 00:00:00 +0100 5484792 http://www.medworm.com/index.php?rid=5484791&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901441-3 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484791 Fri, 09 Dec 2011 00:00:00 +0100 5484791 http://www.medworm.com/index.php?rid=5484790&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901374-2 Sergiy Libert, Kelli Pointer, Eric L. Bell, Abhirup Das, Dena E. Cohen, John M. Asara, Karen Kapur, Sven Bergmann, Martin Preisig, Takeshi Otowa, Kenneth S. Kendler, Xiangning Chen, John M. Hettema, Edwin J. van den Oord, Justin P. Rubio, Leonard Guarente. SIRT1 is a NAD+-dependent deacetylase that governs a number of genetic programs to cope with changes in the nutritional status of cells and organisms. Behavioral responses to food abund.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5484790 Thu, 08 Dec 2011 00:00:00 +0100 5484790 http://www.medworm.com/index.php?rid=5466766&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901339-0 Andrey Feklistov, Seth A. Darst. The key step in bacterial promoter opening is recognition of the −10 promoter element (T−12A−11T−10A−9A−8T−7 consensus sequence) b.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5466766 Thu, 01 Dec 2011 00:00:00 +0100 5466766 http://www.medworm.com/index.php?rid=5448445&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901353-5 Robert Kasper, Bo Huang. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448445 Wed, 23 Nov 2011 00:00:00 +0100 5448445 http://www.medworm.com/index.php?rid=5448444&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901338-9 Inbal Goshen, Matthew Brodsky, Rohit Prakash, Jenelle Wallace, Viviana Gradinaru, Charu Ramakrishnan, Karl Deisseroth. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448444 Wed, 23 Nov 2011 00:00:00 +0100 5448444 http://www.medworm.com/index.php?rid=5448443&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901340-7 Guy S. Salvesen, Avi Ashkenazi. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448443 Wed, 23 Nov 2011 00:00:00 +0100 5448443 http://www.medworm.com/index.php?rid=5448442&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901342-0 Piyush B. Gupta, Christine M. Fillmore, Guozhi Jiang, Sagi D. Shapira, Kai Tao, Charlotte Kuperwasser, Eric S. Lander. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448442 Wed, 23 Nov 2011 00:00:00 +0100 5448442 http://www.medworm.com/index.php?rid=5448441&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901291-8 Chuankai Zhou, Brian D. Slaughter, Jay R. Unruh, Amr Eldakak, Boris Rubinstein, Rong Li. During yeast cell division, aggregates of damaged proteins are segregated asymmetrically between the bud and the mother. It is thought that protein aggregates are cleared from the bud via actin ca.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448441 Wed, 23 Nov 2011 00:00:00 +0100 5448441 http://www.medworm.com/index.php?rid=5448440&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901268-2 We present the draft 273 Mb genome of the migratory monarch butterfly (Danaus plexippus) and a set of 16,866 protein-coding genes. Orthology properties suggest that the Lepidoptera are the .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448440 Wed, 23 Nov 2011 00:00:00 +0100 5448440 http://www.medworm.com/index.php?rid=5448439&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901269-4 Satoshi Yamazaki, Hideo Ema, Göran Karlsson, Tomoyuki Yamaguchi, Hiroyuki Miyoshi, Seiji Shioda, Makoto M. Taketo, Stefan Karlsson, Atsushi Iwama, Hiromitsu Nakauchi. Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial. Here, we demon.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448439 Wed, 23 Nov 2011 00:00:00 +0100 5448439 http://www.medworm.com/index.php?rid=5448438&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901273-6 Thomas Montavon, Natalia Soshnikova, Bénédicte Mascrez, Elisabeth Joye, Laurie Thevenet, Erik Splinter, Wouter de Laat, François Spitz, Denis Duboule. The evolution of digits was an essential step in the success of tetrapods. Among the key players, Hoxd genes are coordinately regulated in developing digits, where they help organize growth.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448438 Wed, 23 Nov 2011 00:00:00 +0100 5448438 http://www.medworm.com/index.php?rid=5448437&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901288-8 Sharon E. Miller, Daniela A. Sahlender, Stephen C. Graham, Stefan Höning, Margaret S. Robinson, Andrew A. Peden, David J. Owen. SNAREs provide a large part of the specificity and energy needed for membrane fusion and, to do so, must be localized to their correct membranes. Here, we show that the R-SNAREs VAMP8, VAMP3, and .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448437 Wed, 23 Nov 2011 00:00:00 +0100 5448437 http://www.medworm.com/index.php?rid=5448436&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901271-2 Jason A. MacGurn, Pi-Chiang Hsu, Marcus B. Smolka, Scott D. Emr. The TORC1 kinase signaling complex is a key determinant of cell growth that senses nutritional status and responds by coordinating diverse cellular processes including transcription, translation, .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448436 Wed, 23 Nov 2011 00:00:00 +0100 5448436 http://www.medworm.com/index.php?rid=5448435&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901287-6 Melissa K. Gardner, Marija Zanic, Christopher Gell, Volker Bormuth, Jonathon Howard. Microtubules are dynamic filaments whose ends alternate between periods of slow growth and rapid shortening as they explore intracellular space and move organelles. A key question is how regulator.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448435 Wed, 23 Nov 2011 00:00:00 +0100 5448435 http://www.medworm.com/index.php?rid=5448434&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901289-X Elena Piskounova, Christos Polytarchou, James E. Thornton, Robert J. LaPierre, Charalabos Pothoulakis, John P. Hagan, Dimitrios Iliopoulos, Richard I. Gregory. Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase (Zcchc11/TUT4) to let-7 precursors to block .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448434 Wed, 23 Nov 2011 00:00:00 +0100 5448434 http://www.medworm.com/index.php?rid=5448433&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901274-8 Diana Y. Vargas, Khyati Shah, Mona Batish, Michael Levandoski, Sourav Sinha, Salvatore A.E. Marras, Paul Schedl, Sanjay Tyagi. Introns are removed from pre-mRNAs during transcription while the pre-mRNA is still tethered to the gene locus via RNA polymerase. However, during alternative splicing, it is important that splici.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448433 Wed, 23 Nov 2011 00:00:00 +0100 5448433 http://www.medworm.com/index.php?rid=5448432&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901275-X Hans Hombauer, Christopher S. Campbell, Catherine E. Smith, Arshad Desai, Richard D. Kolodner. DNA mismatch repair (MMR) increases replication fidelity by eliminating mispaired bases resulting from replication errors. In Saccharomyces cerevisiae, mispairs are primarily detected by th.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448432 Wed, 23 Nov 2011 00:00:00 +0100 5448432 http://www.medworm.com/index.php?rid=5448431&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901285-2 Eric S. Fischer, Andrea Scrima, Kerstin Böhm, Syota Matsumoto, Gondichatnahalli M. Lingaraju, Mahamadou Faty, Takeshi Yasuda, Simone Cavadini, Mitsuo Wakasugi, Fumio Hanaoka, Shigenori Iwai, Heinz Gut, Kaoru Sugasawa, Nicolas H. Thomä. The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-induced pyrimidine dimers in .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448431 Wed, 23 Nov 2011 00:00:00 +0100 5448431 http://www.medworm.com/index.php?rid=5448430&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901272-4 Miguel Fribourg, José L. Moreno, Terrell Holloway, Davide Provasi, Lia Baki, Rahul Mahajan, Gyu Park, Scott K. Adney, Candice Hatcher, José M. Eltit, Jeffrey D. Ruta, Laura Albizu, Zheng Li, Adrienne Umali, Jihyun Shim, Alexandre Fabiato, Alexander D. MacKerell, Vladimir Brezina, Stuart C. Sealfon, Marta Filizola, Javier González-Maeso, Diomedes E. Logothetis. Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-HT2A G protein-coupled receptor (GPCR), the 2AR, which signals via a Gq (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448430 Wed, 23 Nov 2011 00:00:00 +0100 5448430 http://www.medworm.com/index.php?rid=5448429&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901354-7 Peter Friedl, Stephanie Alexander. Cancer invasion is a cell- and tissue-driven process for which the physical, cellular, and molecular determinants adapt and react throughout the progression of the disease. Cancer invasion is init.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448429 Wed, 23 Nov 2011 00:00:00 +0100 5448429 http://www.medworm.com/index.php?rid=5448428&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901334-1 Mikael J. Pittet, Ralph Weissleder. Until recently, the idea of observing life deep within the tissues of a living mouse, at a resolution sufficient to pick out cellular behaviors and molecular signals underlying them, remained a mu.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448428 Wed, 23 Nov 2011 00:00:00 +0100 5448428 http://www.medworm.com/index.php?rid=5448427&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901355-9 Allard J. Katan, Cees Dekker. Atomic force microscopy allows visualization of biomolecules with nanometer resolution under physiological conditions. Recent advances have improved the time resolution of the technique from minut.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448427 Wed, 23 Nov 2011 00:00:00 +0100 5448427 http://www.medworm.com/index.php?rid=5448426&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901290-6 Gaudenz Danuser. Computer vision refers to the theory and implementation of artificial systems that extract information from images to understand their content. Although computers are widely used by cell biologist.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448426 Wed, 23 Nov 2011 00:00:00 +0100 5448426 http://www.medworm.com/index.php?rid=5448425&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901343-2 Marcus C. Stensmyr, Bill S. Hansson. The monarch butterfly is famous for its annual fall migration from eastern North America to central Mexico, but it has also been an important model for studies in long-distance migration. Now, Zha.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448425 Wed, 23 Nov 2011 00:00:00 +0100 5448425 http://www.medworm.com/index.php?rid=5448424&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901337-7 Mayank R. Mehta. The brain's grid and place cells, which contribute to spatial representations of the external environment, are thought to be modulated by the hyperpolarization-activated cation current (Ih (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448424 Wed, 23 Nov 2011 00:00:00 +0100 5448424 http://www.medworm.com/index.php?rid=5448423&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901345-6 Anna Akhmanova, Marileen Dogterom. The ability of growing microtubules to undergo catastrophes—abrupt switches from growth to shortening—is one of the key aspects of microtubule dynamics important for shaping cellular microtubule a.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448423 Wed, 23 Nov 2011 00:00:00 +0100 5448423 http://www.medworm.com/index.php?rid=5448422&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901346-8 Mari Kondo, Akira Sawa. In this issue, Fribourg et al. provide insight into a molecular basis of psychosis. They reveal that a heteromeric complex formed by the G protein-coupled receptors (GPCRs) for glutamate and serot.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448422 Wed, 23 Nov 2011 00:00:00 +0100 5448422 http://www.medworm.com/index.php?rid=5448421&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901333-X Kristian E. Baker, Timothy W. Nilsen. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448421 Wed, 23 Nov 2011 00:00:00 +0100 5448421 http://www.medworm.com/index.php?rid=5448420&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901356-0 Beidong Liu, Lisa Larsson, Vanessa Franssens, Xinxin Hao, Sandra Malmgren Hill, Veronica Andersson, Daniel Höglund, Jia Song, Xiaoxue Yang, David Öling, Julie Grantham, Joris Winderickx, Thomas Nyström. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448420 Wed, 23 Nov 2011 00:00:00 +0100 5448420 http://www.medworm.com/index.php?rid=5448419&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901357-2 Medicine in the West is increasingly focused on treating age-related diseases such as cancer and cardiovascular disease. Are we now ready for the next big leap: to treat not just the symptoms of a.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448419 Wed, 23 Nov 2011 00:00:00 +0100 5448419 http://www.medworm.com/index.php?rid=5448418&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901344-4 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448418 Wed, 23 Nov 2011 00:00:00 +0100 5448418 http://www.medworm.com/index.php?rid=5448417&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901341-9 Oded Rechavi, Gregory Minevich, Oliver Hobert. Induced expression of the Flock House virus in the soma of C. elegans results in the RNAi-dependent production of virus-derived, small-interfering RNAs (viRNAs), which in turn silence the v.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5448417 Wed, 23 Nov 2011 00:00:00 +0100 5448417 http://www.medworm.com/index.php?rid=5419782&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2811%2901135-4 Lisa M. Giocomo, Syed A. Hussaini, Fan Zheng, Eric R. Kandel, May-Britt Moser, Edvard I. Moser. Entorhinal grid cells have periodic, hexagonally patterned firing locations that scale up progressively along the dorsal-ventral axis of medial entorhinal cortex. This topographic expansion corres.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5419782 Thu, 17 Nov 2011 00:00:00 +0100 5419782 http://www.medworm.com/index.php?rid=5398316&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901286-4 Douglas R. Green, Bennett Van Houten. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5398316 Fri, 11 Nov 2011 00:00:00 +0100 5398316 http://www.medworm.com/index.php?rid=5398315&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901284-0 Joshua P. Johansen, Christopher K. Cain, Linnaea E. Ostroff, Joseph E. LeDoux. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5398315 Fri, 11 Nov 2011 00:00:00 +0100 5398315 http://www.medworm.com/index.php?rid=5398314&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901282-7 Florian A. Karreth, Yvonne Tay, Daniele Perna, Ugo Ala, Shen Mynn Tan, Alistair G. Rust, Gina DeNicola, Kaitlyn A. Webster, Dror Weiss, Pedro A. Perez-Mancera, Michael Krauthammer, Ruth Halaban, Paolo Provero, David J. Adams, David A. Tuveson, Pier Paolo Pandolfi. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5398314 Fri, 11 Nov 2011 00:00:00 +0100 5398314 http://www.medworm.com/index.php?rid=5398313&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2811%2901281-5 Marcella Cesana, Davide Cacchiarelli, Ivano Legnini, Tiziana Santini, Olga Sthandier, Mauro Chinappi, Anna Tramontano, Irene Bozzoni. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=5398313 Fri, 11 Nov 2011 00:00:00 +0100 5398313