MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cell' source. Sat, 20 Mar 2010 16:35:06 +0100 http://www.medworm.com/index.php?rid=3382576&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900244-8 Carl Nathan, Aihao Ding. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382576 Fri, 19 Mar 2010 04:00:10 +0100 3382576 http://www.medworm.com/index.php?rid=3382575&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900236-9 Charles A. Dinarello. Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammat.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382575 Fri, 19 Mar 2010 04:00:10 +0100 3382575 http://www.medworm.com/index.php?rid=3382574&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900168-6 Christopher K. Glass, Kaoru Saijo, Beate Winner, Maria Carolina Marchetto, Fred H. Gage. Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discu.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382574 Fri, 19 Mar 2010 04:00:10 +0100 3382574 http://www.medworm.com/index.php?rid=3382573&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900187-X Gökhan S. Hotamisligil. The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's adaptive capacity results in activat.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382573 Fri, 19 Mar 2010 04:00:10 +0100 3382573 http://www.medworm.com/index.php?rid=3382572&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900060-7 Sergei I. Grivennikov, Florian R. Greten, Michael Karin. Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immu.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382572 Fri, 19 Mar 2010 04:00:10 +0100 3382572 http://www.medworm.com/index.php?rid=3382571&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900182-0 Carl Nathan, Aihao Ding. Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an inherent risk because inflammation can damage tissue and necrosis can provoke inflammation. Nonetheless, .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382571 Fri, 19 Mar 2010 04:00:10 +0100 3382571 http://www.medworm.com/index.php?rid=3382570&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900024-3 Wendy S. Garrett, Jeffrey I. Gordon, Laurie H. Glimcher. The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutuall.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382570 Fri, 19 Mar 2010 04:00:10 +0100 3382570 http://www.medworm.com/index.php?rid=3382569&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900174-1 Dan R. Littman, Alexander Y. Rudensky. The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382569 Fri, 19 Mar 2010 04:00:10 +0100 3382569 http://www.medworm.com/index.php?rid=3382568&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900072-3 Stephen T. Smale. An inflammatory response is initiated by the temporally controlled activation of genes encoding a broad range of regulatory and effector proteins. A central goal is to devise strategies for the se.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382568 Fri, 19 Mar 2010 04:00:10 +0100 3382568 http://www.medworm.com/index.php?rid=3382567&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900075-9 Kate Schroder, Jurg Tschopp. Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate immune defenses. .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382567 Fri, 19 Mar 2010 04:00:10 +0100 3382567 http://www.medworm.com/index.php?rid=3382566&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900023-1 Osamu Takeuchi, Shizuo Akira. Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like recep.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382566 Fri, 19 Mar 2010 04:00:10 +0100 3382566 http://www.medworm.com/index.php?rid=3382565&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900167-4 Laurence Zitvogel, Oliver Kepp, Guido Kroemer. Dying cells release and expose at their surface molecules that signal to the immune system. We speculate that combinations of these molecules determine the route by which dying cells are engulfed .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382565 Fri, 19 Mar 2010 04:00:10 +0100 3382565 http://www.medworm.com/index.php?rid=3382564&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900239-4 Lauren A. Zenewicz, Clara Abraham, Richard A. Flavell, Judy H. Cho. The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations sh.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382564 Fri, 19 Mar 2010 04:00:10 +0100 3382564 http://www.medworm.com/index.php?rid=3382563&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900238-2 Daniel L. Kastner, Ivona Aksentijevich, Raphaela Goldbach-Mansky. Our understanding of the etiology of autoinflammatory disease is growing rapidly. Recent advances offer new opportunities for therapeutic intervention and suggest that the definition of what const.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382563 Fri, 19 Mar 2010 04:00:10 +0100 3382563 http://www.medworm.com/index.php?rid=3382562&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900240-0 Richard M. Locksley. Studies of the initiation and maintenance of asthma and allergic inflammation implicate dysregulated interactions between mucosal epithelia and innate immune cells as the underlying cause of these.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382562 Fri, 19 Mar 2010 04:00:10 +0100 3382562 http://www.medworm.com/index.php?rid=3382561&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900242-4 Ruslan Medzhitov. Inflammation is an essential immune response that enables survival during infection or injury and maintains tissue homeostasis under a variety of noxious conditions. Inflammation comes at the cost.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382561 Fri, 19 Mar 2010 04:00:10 +0100 3382561 http://www.medworm.com/index.php?rid=3382560&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900241-2 Inflammation is the body's defense against infection by pathogens, tissue injury, or cancer. The inflammatory response requires the eloquent orchestration of multiple networks of cells from both t.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382560 Fri, 19 Mar 2010 04:00:10 +0100 3382560 http://www.medworm.com/index.php?rid=3382559&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900243-6 We live in a microbial world and are often confronted with infection and injury. Inflammation, the response that is unleashed to ward off these insults, has long been familiar to us. Indeed, the w.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382559 Fri, 19 Mar 2010 04:00:10 +0100 3382559 http://www.medworm.com/index.php?rid=3382558&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900190-X Viviana Gradinaru, Feng Zhang, Charu Ramakrishnan, Joanna Mattis, Rohit Prakash, Ilka Diester, Inbal Goshen, Kimberly R. Thompson, Karl Deisseroth. Optogenetic technologies employ light to control biological processes within targeted cells in vivo with high temporal precision. Here, we show that application of molecular trafficking principles.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382558 Fri, 19 Mar 2010 04:00:09 +0100 3382558 http://www.medworm.com/index.php?rid=3382557&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900019-X Alex Boehm, Matthias Kaiser, Hui Li, Christian Spangler, Christoph Alexander Kasper, Martin Ackermann, Volkhard Kaever, Victor Sourjik, Volker Roth, Urs Jenal. Bacteria swim by means of rotating flagella that are powered by ion influx through membrane-spanning motor complexes. Escherichia coli and related species harness a chemosensory and signal .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3382557 Fri, 19 Mar 2010 04:00:09 +0100 3382557 http://www.medworm.com/index.php?rid=3335134&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900186-8 Caixia Guo, Tie-Shan Tang, Errol C. Friedberg. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335134 Fri, 05 Mar 2010 04:00:45 +0100 3335134 http://www.medworm.com/index.php?rid=3335133&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900184-4 Ehud Cohen, Johan F. Paulsson, Pablo Blinder, Tal Burstyn-Cohen, Deguo Du, Gabriela Estepa, Anthony Adame, Hang M. Pham, Martin Holzenberger, Jeffery W. Kelly, Eliezer Masliah, Andrew Dillin. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335133 Fri, 05 Mar 2010 04:00:45 +0100 3335133 http://www.medworm.com/index.php?rid=3335132&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900079-6 Timothy Ravasi, Harukazu Suzuki, Carlo Vittorio Cannistraci, Shintaro Katayama, Vladimir B. Bajic, Kai Tan, Altuna Akalin, Sebastian Schmeier, Mutsumi Kanamori-Katayama, Nicolas Bertin, Piero Carninci, Carsten O. Daub, Alistair R.R. Forrest, Julian Gough, Sean Grimmond, Jung-Hoon Han, Takehiro Hashimoto, Winston Hide, Oliver Hofmann, Hideya Kawaji, Atsutaka Kubosaki, Timo Lassmann, Erik van Nimwegen, Chihiro Ogawa, Rohan D. Teasdale, Jesper Tegnér, Boris Lenhard, Sarah A. Teichmann, Takahiro Arakawa, Noriko Ninomiya, Kayoko Murakami, Michihira Tagami, Shiro Fukuda, Kengo Imamura, Chikatoshi Kai, Ryoko Ishihara, Yayoi Kitazume, Jun Kawai, David A. Hume, Trey Ideker, Yoshihide Hayashizaki. Combinatorial interactions among transcription factors are critical to directing tissue-specific gene ... Cell journals http://www.medworm.com/rss/comments.php?id=3335132 Fri, 05 Mar 2010 04:00:45 +0100 3335132 http://www.medworm.com/index.php?rid=3335131&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900127-3 Dhiraj Kumar, Lekha Nath, Md. Azhar Kamal, Ankur Varshney, Avinash Jain, Sarman Singh, Kanury V.S. Rao. We performed a genome-wide siRNA screen to identify host factors that regulated pathogen load in human macrophages infected with a virulent strain of Mycobacterium tuberculosis. Iterative r.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335131 Fri, 05 Mar 2010 04:00:45 +0100 3335131 http://www.medworm.com/index.php?rid=3335130&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900128-5 David M. Tobin, Jay C. Vary, John P. Ray, Gregory S. Walsh, Sarah J. Dunstan, Nguyen D. Bang, Deanna A. Hagge, Saraswoti Khadge, Mary-Claire King, Thomas R. Hawn, Cecilia B. Moens, Lalita Ramakrishnan. Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from a forward genetic screen in z.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335130 Fri, 05 Mar 2010 04:00:45 +0100 3335130 http://www.medworm.com/index.php?rid=3335129&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900061-9 Paul L. Greer, Rikinari Hanayama, Brenda L. Bloodgood, Alan R. Mardinly, David M. Lipton, Steven W. Flavell, Tae-Kyung Kim, Eric C. Griffith, Zachary Waldon, Rene Maehr, Hidde L. Ploegh, Shoaib Chowdhury, Paul F. Worley, Judith Steen, Michael E. Greenberg. Angelman Syndrome is a debilitating neurological disorder caused by mutation of the E3 ubiquitin ligase Ube3A, a gene whose mutation has also recently been associated with autism spectrum d.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335129 Fri, 05 Mar 2010 04:00:45 +0100 3335129 http://www.medworm.com/index.php?rid=3335128&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900125-X Tomoko Noto, Henriette M. Kurth, Kensuke Kataoka, Lucia Aronica, Leroi V. DeSouza, K.W. Michael Siu, Ronald E. Pearlman, Martin A. Gorovsky, Kazufumi Mochizuki. Emerging evidence suggests that RNA interference (RNAi)-related processes act both in the cytoplasm and in the nucleus. However, the process by which the RNAi machinery is transported into the nuc.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335128 Fri, 05 Mar 2010 04:00:44 +0100 3335128 http://www.medworm.com/index.php?rid=3335127&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900004-8 Aaron D. Goldberg, Laura A. Banaszynski, Kyung-Min Noh, Peter W. Lewis, Simon J. Elsaesser, Sonja Stadler, Scott Dewell, Martin Law, Xingyi Guo, Xuan Li, Duancheng Wen, Ariane Chapgier, Russell C. DeKelver, Jeffrey C. Miller, Ya-Li Lee, Elizabeth A. Boydston, Michael C. Holmes, Philip D. Gregory, John M. Greally, Shahin Rafii, Chingwen Yang, Peter J. Scambler, David Garrick, Richard J. Gibbons, Douglas R. Higgs, Ileana M. Cristea, Fyodor D. Urnov, Deyou Zheng, C. David Allis. The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3.3, we report genome-wi.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335127 Fri, 05 Mar 2010 04:00:44 +0100 3335127 http://www.medworm.com/index.php?rid=3335126&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900073-5 Elizabeth H. Bayne, Sharon A. White, Alexander Kagansky, Dominika A. Bijos, Luis Sanchez-Pulido, Kwang-Lae Hoe, Dong-Uk Kim, Han-Oh Park, Chris P. Ponting, Juri Rappsilber, Robin C. Allshire. In fission yeast, RNAi directs heterochromatin formation at centromeres, telomeres, and the mating type locus. Noncoding RNAs transcribed from repeat elements generate siRNAs that are incorporated.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335126 Fri, 05 Mar 2010 04:00:44 +0100 3335126 http://www.medworm.com/index.php?rid=3335125&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900008-5 Anna M. Eiring, Jason G. Harb, Paolo Neviani, Christopher Garton, Joshua J. Oaks, Riccardo Spizzo, Shujun Liu, Sebastian Schwind, Ramasamy Santhanam, Christopher J. Hickey, Heiko Becker, Jason C. Chandler, Raul Andino, Jorge Cortes, Peter Hokland, Claudia S. Huettner, Ravi Bhatia, Denis C. Roy, Stephen A. Liebhaber, Michael A. Caligiuri, Guido Marcucci, Ramiro Garzon, Carlo M. Croce, George A. Calin, Danilo Perrotti. MicroRNAs and heterogeneous ribonucleoproteins (hnRNPs) are posttranscriptional gene regulators that bind mRNA in a sequence-specific manner. Here, we report that loss of miR-328 occurs in blast c.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335125 Fri, 05 Mar 2010 04:00:44 +0100 3335125 http://www.medworm.com/index.php?rid=3335124&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900126-1 Naama Geva-Zatorsky, Erez Dekel, Ariel A. Cohen, Tamar Danon, Lydia Cohen, Uri Alon. Drugs and drug combinations have complex biological effects on cells and organisms. Little is known about how drugs affect protein dynamics that determine these effects. Here, we use a dynamic pro.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335124 Fri, 05 Mar 2010 04:00:44 +0100 3335124 http://www.medworm.com/index.php?rid=3335123&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900067-X Lillian K. Fritz-Laylin, Simon E. Prochnik, Michael L. Ginger, Joel B. Dacks, Meredith L. Carpenter, Mark C. Field, Alan Kuo, Alex Paredez, Jarrod Chapman, Jonathan Pham, Shengqiang Shu, Rochak Neupane, Michael Cipriano, Joel Mancuso, Hank Tu, Asaf Salamov, Erika Lindquist, Harris Shapiro, Susan Lucas, Igor V. Grigoriev, W. Zacheus Cande, Chandler Fulton, Daniel S. Rokhsar, Scott C. Dawson. Genome sequences of diverse free-living protists are essential for understanding eukaryotic evolution and molecular and cell biology. The free-living amoeboflagellate Naegleria gruberi belo.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335123 Fri, 05 Mar 2010 04:00:44 +0100 3335123 http://www.medworm.com/index.php?rid=3335122&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900129-7 Shigekazu Nagata, Rikinari Hanayama, Kohki Kawane. To maintain organismal homeostasis, phagocytes engulf dead cells, which are recognized as dead by virtue of a characteristic “eat me” signal exposed on their surface. The dead cells are then trans.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335122 Fri, 05 Mar 2010 04:00:44 +0100 3335122 http://www.medworm.com/index.php?rid=3335121&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900183-2 Marcel Behr, Erwin Schurr, Philippe Gros. Mycobacteria, the pathogens that cause tuberculosis and leprosy, establish long-term infections in host macrophages. Recent studies, including two genetic screens reported in this issue of Cell.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335121 Fri, 05 Mar 2010 04:00:44 +0100 3335121 http://www.medworm.com/index.php?rid=3335120&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900173-X Michaela Beitzinger, Gunter Meister. MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now show that miR-328 has a second function, acting as a decoy by binding to hnR.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335120 Fri, 05 Mar 2010 04:00:44 +0100 3335120 http://www.medworm.com/index.php?rid=3335119&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900171-6 Robert J. Johnston, Claude Desplan. In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation in gene expression in Caenorhabditis elegans increases in mutants.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335119 Fri, 05 Mar 2010 04:00:44 +0100 3335119 http://www.medworm.com/index.php?rid=3335118&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900172-8 Hwan-Ching Tai, Erin M. Schuman. Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A sub.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335118 Fri, 05 Mar 2010 04:00:44 +0100 3335118 http://www.medworm.com/index.php?rid=3335117&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900175-3 Eugene V. Koonin. Comparing the genome sequences of free-living organisms in the five eukaryotic supergroups enables predictions to be made about the genome of the last common ancestor of eukaryotes. The genome seq.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335117 Fri, 05 Mar 2010 04:00:44 +0100 3335117 http://www.medworm.com/index.php?rid=3335116&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900170-4 Harvey T. McMahon, Michael M. Kozlov, Sascha Martens. Recent evidence suggests that the Ca2+-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335116 Fri, 05 Mar 2010 04:00:44 +0100 3335116 http://www.medworm.com/index.php?rid=3335115&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900191-1 Faster, smaller, easier, and better—DNA sequencing technologies have improved by quantum leaps in the past decade. This Genetics Select highlights recent studies that demonstrate how these technol.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335115 Fri, 05 Mar 2010 04:00:43 +0100 3335115 http://www.medworm.com/index.php?rid=3335114&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900185-6 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3335114 Fri, 05 Mar 2010 04:00:43 +0100 3335114 http://www.medworm.com/index.php?rid=3287549&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900121-2 R. Luke Wiseman, Cole M. Haynes, David Ron. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287549 Fri, 19 Feb 2010 04:00:12 +0100 3287549 http://www.medworm.com/index.php?rid=3287548&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901630-4 Yichun Shuai, Binyan Lu, Ying Hu, Lianzhang Wang, Kan Sun, Yi Zhong. Initially acquired memory dissipates rapidly if not consolidated. Such memory decay is thought to result either from the inherently labile nature of newly acquired memories or from interference by.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287548 Fri, 19 Feb 2010 04:00:12 +0100 3287548 http://www.medworm.com/index.php?rid=3287547&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900059-0 We report that CaMKIIα—an abundant postsynaptic protein kinase—mediates the activity-de.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287547 Fri, 19 Feb 2010 04:00:12 +0100 3287547 http://www.medworm.com/index.php?rid=3287546&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900062-0 Graziella Messina, Stefano Biressi, Stefania Monteverde, Alessandro Magli, Marco Cassano, Laura Perani, Elena Roncaglia, Enrico Tagliafico, Linda Starnes, Christine E. Campbell, Milena Grossi, David J. Goldhamer, Richard M. Gronostajski, Giulio Cossu. Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription fa.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287546 Fri, 19 Feb 2010 04:00:12 +0100 3287546 http://www.medworm.com/index.php?rid=3287545&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900011-5 Winfried Römer, Léa-Laetitia Pontani, Benoît Sorre, Carles Rentero, Ludwig Berland, Valérie Chambon, Christophe Lamaze, Patricia Bassereau, Cécile Sykes, Katharina Gaus, Ludger Johannes. Nascent transport intermediates detach from donor membranes by scission. This process can take place in the absence of dynamin, notably in clathrin-independent endocytosis, by mechanisms that are .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287545 Fri, 19 Feb 2010 04:00:12 +0100 3287545 http://www.medworm.com/index.php?rid=3287544&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901628-6 Guogang Dong, Qiong Yang, Qiang Wang, Yong-Ick Kim, Thammajun L. Wood, Katherine W. Osteryoung, Alexander van Oudenaarden, Susan S. Golden. A circadian clock coordinates physiology and behavior in diverse groups of living organisms. Another major cyclic cellular event, the cell cycle, is regulated by the circadian clock in the few cas.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287544 Fri, 19 Feb 2010 04:00:12 +0100 3287544 http://www.medworm.com/index.php?rid=3287543&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900010-3 Hyun Ae Woo, Sun Hee Yim, Dong Hae Shin, Dongmin Kang, Dae-Yeul Yu, Sue Goo Rhee. Despite its toxicity, H2O2 is produced as a signaling molecule that oxidizes critical cysteine residues of effectors such as protein tyrosine phosphatases in response to acti.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287543 Fri, 19 Feb 2010 04:00:12 +0100 3287543 http://www.medworm.com/index.php?rid=3287542&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900020-6 Mario Halic, Danesh Moazed. Assembly of fission yeast pericentromeric heterochromatin and generation of small interfering RNAs (siRNAs) from noncoding centromeric transcripts are mutually dependent processes. How this interd.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287542 Fri, 19 Feb 2010 04:00:12 +0100 3287542 http://www.medworm.com/index.php?rid=3287541&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901636-5 Jaehoon Kim, Mohamed Guermah, Robert G. Roeder. Genetic and cell-based studies have implicated the PAF1 complex (PAF1C) in transcription-associated events, but there has been no evidence showing a direct role in facilitating transcription of a .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287541 Fri, 19 Feb 2010 04:00:12 +0100 3287541 http://www.medworm.com/index.php?rid=3287540&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900064-4 Wei Li, Liru You, Jonathan Cooper, Gaia Schiavon, Angela Pepe-Caprio, Lu Zhou, Ryohei Ishii, Marco Giovannini, C. Oliver Hanemann, Stephen B. Long, Hediye Erdjument-Bromage, Pengbo Zhou, Paul Tempst, Filippo G. Giancotti. Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, gr.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287540 Fri, 19 Feb 2010 04:00:12 +0100 3287540 http://www.medworm.com/index.php?rid=3287539&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900115-7 Tuomas Tammela, Kari Alitalo. The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287539 Fri, 19 Feb 2010 04:00:12 +0100 3287539 http://www.medworm.com/index.php?rid=3287538&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900117-0 Jörg Morf, Ueli Schibler. In cyanobacteria cell division is intimately linked with the circadian cycle. Dong et al. (2010) now identify components of the circadian clock that regulate the formation of the midcell ring for .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287538 Fri, 19 Feb 2010 04:00:12 +0100 3287538 http://www.medworm.com/index.php?rid=3287537&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900119-4 Ronald L. Davis. Forgetting has been thought to occur as a result of the natural decay of the neuronal changes induced by learning or because of interference from other cognitive functions. In this issue, Shuai et.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287537 Fri, 19 Feb 2010 04:00:12 +0100 3287537 http://www.medworm.com/index.php?rid=3287536&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900118-2 Michel B. Toledano, Anne-Gaëlle Planson, Agnès Delaunay-Moisan. Mammalian cells use hydrogen peroxide (H2O2) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287536 Fri, 19 Feb 2010 04:00:12 +0100 3287536 http://www.medworm.com/index.php?rid=3287535&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900120-0 Darryl Conte, Craig C. Mello. The amplification of small RNAs and the assembly of heterochromatin are mutually dependent processes in fission yeast. But which comes first? Halic and Moazed (2010) propose that primal small RNAs.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287535 Fri, 19 Feb 2010 04:00:12 +0100 3287535 http://www.medworm.com/index.php?rid=3287534&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900116-9 Edward Scolnick. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287534 Fri, 19 Feb 2010 04:00:12 +0100 3287534 http://www.medworm.com/index.php?rid=3287533&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900122-4 Srinivas R. Viswanathan, George Q. Daley. Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic underst.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287533 Fri, 19 Feb 2010 04:00:12 +0100 3287533 http://www.medworm.com/index.php?rid=3287532&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900124-8 Ongoing efforts to link patterns of neural activity to cognition and behavior entail the use of an impressive range of techniques, from single-cell recording to functional magnetic resonance imagi.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287532 Fri, 19 Feb 2010 04:00:11 +0100 3287532 http://www.medworm.com/index.php?rid=3287531&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900123-6 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3287531 Fri, 19 Feb 2010 04:00:11 +0100 3287531 http://www.medworm.com/index.php?rid=3243549&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900076-0 Lijun Sun, Siqi Liu, Zhijian J. Chen. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243549 Fri, 05 Feb 2010 04:00:08 +0100 3243549 http://www.medworm.com/index.php?rid=3243548&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900009-7 Kausik Si, Yun-Beom Choi, Erica White-Grindley, Amitabha Majumdar, Eric R. Kandel. Prions are proteins that can assume at least two distinct conformational states, one of which is dominant and self-perpetuating. Previously we found that a translation regulator CPEB from Aplys.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243548 Fri, 05 Feb 2010 04:00:08 +0100 3243548 http://www.medworm.com/index.php?rid=3243547&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900003-6 Bettina Spitzweck, Marko Brankatschk, Barry J. Dickson. The orthogonal array of axon pathways in the Drosophila CNS is constructed in part under the control of three Robo family axon guidance receptors: Robo1, Robo2 and Robo3. Each of these rece.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243547 Fri, 05 Feb 2010 04:00:08 +0100 3243547 http://www.medworm.com/index.php?rid=3243546&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900021-8 Jan Rehwinkel, Choon Ping Tan, Delphine Goubau, Oliver Schulz, Andreas Pichlmair, Katja Bier, Nicole Robb, Frank Vreede, Wendy Barclay, Ervin Fodor, Caetano Reis e Sousa. RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA viruses to the induction of interferons. Natural RIG-I stimulatory RNAs have variously been proposed to .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243546 Fri, 05 Feb 2010 04:00:08 +0100 3243546 http://www.medworm.com/index.php?rid=3243545&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901681-X Maya Capelson, Yun Liang, Roberta Schulte, William Mair, Ulrich Wagner, Martin W. Hetzer. Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243545 Fri, 05 Feb 2010 04:00:08 +0100 3243545 http://www.medworm.com/index.php?rid=3243544&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900012-7 Bernike Kalverda, Helen Pickersgill, Victor V. Shloma, Maarten Fornerod. Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. In yeast, they also interact with active genes, attracting or retaining them at the nuclear periphery. In higher eukary.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243544 Fri, 05 Feb 2010 04:00:08 +0100 3243544 http://www.medworm.com/index.php?rid=3243543&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900002-4 Takahisa Nakamura, Masato Furuhashi, Ping Li, Haiming Cao, Gurol Tuncman, Nahum Sonenberg, Cem Z. Gorgun, Gökhan S. Hotamisligil. As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest in understanding the mechanisms of insulin resistance, type .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243543 Fri, 05 Feb 2010 04:00:08 +0100 3243543 http://www.medworm.com/index.php?rid=3243542&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901680-8 Polina V. Lishko, Inna L. Botchkina, Andriy Fedorenko, Yuriy Kirichok. Human spermatozoa are quiescent in the male reproductive system and must undergo activation once introduced into the female reproductive tract. This process is known to require alkalinization of s.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243542 Fri, 05 Feb 2010 04:00:08 +0100 3243542 http://www.medworm.com/index.php?rid=3243541&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900063-2 Noboru Mizushima, Tamotsu Yoshimori, Beth Levine. Autophagy has been implicated in many physiological and pathological processes. Accordingly, there is a growing scientific need to accurately identify, quantify, and manipulate the process of auto.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243541 Fri, 05 Feb 2010 04:00:08 +0100 3243541 http://www.medworm.com/index.php?rid=3243540&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900070-X Harvey M. Florman, Melissa K. Jungnickel, Keith A. Sutton. The acquisition of fertilization capacity by sperm is regulated by intracellular pH (pHi), but the transport pathways that regulate pHi are not well understood. Lishko et al..... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243540 Fri, 05 Feb 2010 04:00:08 +0100 3243540 http://www.medworm.com/index.php?rid=3243539&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900069-3 Aart G. Jochemsen, Yosef Shiloh. The tumor suppressor protein p53, a crucial player in the DNA damage response, is regulated in many ways, most notably through ubiquitination. In this issue, Yuan et al. (2010) identify the deubiq.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243539 Fri, 05 Feb 2010 04:00:08 +0100 3243539 http://www.medworm.com/index.php?rid=3243538&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900071-1 Chunhui Hou, Victor G. Corces. Although components of the nuclear pore complex have been implicated in gene regulation independent of their role at the nuclear envelope, the evidence so far has been indirect. Capelson et al. (2.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243538 Fri, 05 Feb 2010 04:00:08 +0100 3243538 http://www.medworm.com/index.php?rid=3243537&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900065-6 Colin Macilwain. The UK's Medical Research Council is losing a charismatic leader, who has worked hard to broaden the agency's remit and who will depart at a time of financial uncertainty for British research. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243537 Fri, 05 Feb 2010 04:00:08 +0100 3243537 http://www.medworm.com/index.php?rid=3243536&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900077-2 Derived from the Greek roots allos and stereos, “allostery” literally means “other object.” Indeed, allosteric mechanisms are often overshadowed by the main action at the acti.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243536 Fri, 05 Feb 2010 04:00:07 +0100 3243536 http://www.medworm.com/index.php?rid=3243535&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900074-7 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3243535 Fri, 05 Feb 2010 04:00:07 +0100 3243535 http://www.medworm.com/index.php?rid=3220263&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901635-3 Akiko Kumagai, Anna Shevchenko, Andrej Shevchenko, William G. Dunphy. TopBP1 has important roles in both DNA replication and checkpoint regulation in vertebrates. We have identified a protein called Treslin that associates with TopBP1 in Xenopus egg extracts..... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3220263 Fri, 29 Jan 2010 04:00:08 +0100 3220263 http://www.medworm.com/index.php?rid=3197468&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900007-3 Ana Toste Rego, Rémi Fronzes, Gabriel Waksman. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197468 Fri, 22 Jan 2010 04:00:08 +0100 3197468 http://www.medworm.com/index.php?rid=3197467&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901627-4 Lei Zhong, Agustina D'Urso, Debra Toiber, Carlos Sebastian, Ryan E. Henry, Douangsone D. Vadysirisack, Alexander Guimaraes, Brett Marinelli, Jakob D. Wikstrom, Tomer Nir, Clary B. Clish, Bhavapriya Vaitheesvaran, Othon Iliopoulos, Irwin Kurland, Yuval Dor, Ralph Weissleder, Orian S. Shirihai, Leif W. Ellisen, Joaquin M. Espinosa, Raul Mostoslavsky. SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally b.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197467 Fri, 22 Jan 2010 04:00:08 +0100 3197467 http://www.medworm.com/index.php?rid=3197466&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901632-8 Beate M. Lichtenberger, Poi Kiang Tan, Heide Niederleithner, Napoleone Ferrara, Peter Petzelbauer, Maria Sibilia. It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF i.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197466 Fri, 22 Jan 2010 04:00:08 +0100 3197466 http://www.medworm.com/index.php?rid=3197465&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901617-1 Beidong Liu, Lisa Larsson, Antonio Caballero, Xinxin Hao, David Öling, Julie Grantham, Thomas Nyström. The paradigm sirtuin, Sir2p, of budding yeast is required for establishing cellular age asymmetry, which includes the retention of damaged and aggregated proteins in mother cells. By establishing .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197465 Fri, 22 Jan 2010 04:00:08 +0100 3197465 http://www.medworm.com/index.php?rid=3197464&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901619-5 Bingke Yu, Ilídio R.S. Martins, Pilong Li, Gaya K. Amarasinghe, Junko Umetani, Martin E. Fernandez-Zapico, Daniel D. Billadeau, Mischa Machius, Diana R. Tomchick, Michael K. Rosen. Vav proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. They control processes including T cell activation, phagocytosis, and migration of normal and transformed cells..... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197464 Fri, 22 Jan 2010 04:00:08 +0100 3197464 http://www.medworm.com/index.php?rid=3197463&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901629-8 Anne Royou, Mary E. Gagou, Roger Karess, William Sullivan. The mechanisms that safeguard cells against chromosomal instability (CIN) are of great interest, as CIN contributes to tumorigenesis. To gain insight into these mechanisms, we studied the behavior.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197463 Fri, 22 Jan 2010 04:00:08 +0100 3197463 http://www.medworm.com/index.php?rid=3197462&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901682-1 Weihong Tu, Xin Xu, Lisheng Peng, Xiaofen Zhong, Wenfeng Zhang, Mangala M. Soundarapandian, Cherine Balel, Manqi Wang, Nali Jia, Wen Zhang, Frank Lew, Sic Lung Chan, Yanfang Chen, Youming Lu. N-methyl-D-aspartate (NMDA) receptors constitute a major subtype of glutamate receptors at extrasynaptic sites that link multiple intracellular catabolic processes responsible for ir.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197462 Fri, 22 Jan 2010 04:00:08 +0100 3197462 http://www.medworm.com/index.php?rid=3197461&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901626-2 We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent BRAF binding to CRAF, C.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197461 Fri, 22 Jan 2010 04:00:08 +0100 3197461 http://www.medworm.com/index.php?rid=3197460&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901638-9 Eek Joong Park, Jun Hee Lee, Guann-Yi Yu, Guobin He, Syed Raza Ali, Ryan G. Holzer, Christoph H. Österreicher, Hiroyuki Takahashi, Michael Karin. Epidemiological studies indicate that overweight and obesity are associated with increased cancer risk. To study how obesity augments cancer risk and development, we focused on hepatocellular carc.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197460 Fri, 22 Jan 2010 04:00:08 +0100 3197460 http://www.medworm.com/index.php?rid=3197459&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900005-X Monica Ransom, Briana K. Dennehey, Jessica K. Tyler. Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197459 Fri, 22 Jan 2010 04:00:08 +0100 3197459 http://www.medworm.com/index.php?rid=3197458&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900014-0 Lawrence N. Kwong, Lynda Chin. Targeted molecular therapies for cancer treatment have shown promise, but also have limitations. In this issue, Heidorn et al. (2010) find that a class of targeted molecular therapies with clinica.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197458 Fri, 22 Jan 2010 04:00:08 +0100 3197458 http://www.medworm.com/index.php?rid=3197457&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900006-1 Gary J. Gorbsky. A cell undergoing mitosis is presented with a potentially catastrophic situation when a DNA double-strand break creates a chromosome fragment that lacks connection to a centromere. Royou et al. (2.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197457 Fri, 22 Jan 2010 04:00:08 +0100 3197457 http://www.medworm.com/index.php?rid=3197456&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900016-4 Leonard Guarente. Propagation of a species requires periodic cell renewal to avoid clonal senescence. Liu et al. (2010) now describe a new mechanism of cell renewal in budding yeast, in which damaged protein aggreg.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197456 Fri, 22 Jan 2010 04:00:08 +0100 3197456 http://www.medworm.com/index.php?rid=3197455&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900015-2 Henry G.S. Martin, Yu Tian Wang. Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-asso.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197455 Fri, 22 Jan 2010 04:00:08 +0100 3197455 http://www.medworm.com/index.php?rid=3197454&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900013-9 Amy Maxmen. In our increasingly networked world, prizes are gaining a foothold in the race for innovation in science and technology. Amy Maxmen reports. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197454 Fri, 22 Jan 2010 04:00:08 +0100 3197454 http://www.medworm.com/index.php?rid=3197453&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2810%2900022-X From Alzheimer's disease and the obesity epidemic to the chronic health effects of certain viral infections, scientists in academia and big pharma are seeking new therapeutic targets and strategie.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197453 Fri, 22 Jan 2010 04:00:08 +0100 3197453 http://www.medworm.com/index.php?rid=3197452&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2810%2900017-6 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197452 Fri, 22 Jan 2010 04:00:08 +0100 3197452 http://www.medworm.com/index.php?rid=3197451&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901618-3 Jian Yuan, Kuntian Luo, Lizhi Zhang, John C. Cheville, Zhenkun Lou. Stability and localization of p53 is essential for its tumor suppressor function. Ubiquitination by the E3 ubiquitin ligase Mdm2 is the major regulatory mechanism of p53, which induces p53 nuclear.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3197451 Fri, 22 Jan 2010 04:00:07 +0100 3197451 http://www.medworm.com/index.php?rid=3153242&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901633-X Ana Toste Rego, Rémi Fronzes, Gabriel Waksman. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153242 Fri, 08 Jan 2010 04:00:09 +0100 3153242 http://www.medworm.com/index.php?rid=3153241&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901591-8 J. Andrew Pospisilik, Daniel Schramek, Harald Schnidar, Shane J.F. Cronin, Nadine T. Nehme, Xiaoyun Zhang, Claude Knauf, Patrice D. Cani, Karin Aumayr, Jelena Todoric, Martina Bayer, Arvand Haschemi, Vijitha Puviindran, Krisztina Tar, Michael Orthofer, G. Gregory Neely, Georg Dietzl, Armen Manoukian, Martin Funovics, Gerhard Prager, Oswald Wagner, Dominique Ferrandon, Fritz Aberger, Chi-chung Hui, Harald Esterbauer, Josef M. Penninger. Over 1 billion people are estimated to be overweight, placing them at risk for diabetes, cardiovascular disease, and cancer. We performed a systems-level genetic dissection of adiposity regulation.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153241 Fri, 08 Jan 2010 04:00:09 +0100 3153241 http://www.medworm.com/index.php?rid=3153240&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901418-4 S. Vinod Kumar, Philip A. Wigge. Plants are highly sensitive to temperature and can perceive a difference of as little as 1°C. How temperature is sensed and integrated in development is unknown. In a forward genetic screen in .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153240 Fri, 08 Jan 2010 04:00:09 +0100 3153240 http://www.medworm.com/index.php?rid=3153239&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901616-X Jakub Abramson, Matthieu Giraud, Christophe Benoist, Diane Mathis. Aire induces the expression of a battery of peripheral-tissue self-antigens (PTAs) in thymic stromal cells, promoting the clonal deletion of differentiating T cells that recognize them. Just how A.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153239 Fri, 08 Jan 2010 04:00:09 +0100 3153239 http://www.medworm.com/index.php?rid=3153238&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901570-0 Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski, Wolfgang Frank. MicroRNAs (miRNAs) control gene expression in animals and plants. Like another class of small RNAs, siRNAs, they affect gene expression posttranscriptionally. While siRNAs in addition act in trans.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153238 Fri, 08 Jan 2010 04:00:09 +0100 3153238 http://www.medworm.com/index.php?rid=3153237&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901569-4 Caroline J. Woo, Peter V. Kharchenko, Laurence Daheron, Peter J. Park, Robert E. Kingston. Polycomb group (PcG) proteins are essential for accurate axial body patterning during embryonic development. PcG-mediated repression is conserved in metazoans and is targeted in Drosophila .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153237 Fri, 08 Jan 2010 04:00:09 +0100 3153237 http://www.medworm.com/index.php?rid=3153236&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901571-2 Devon P. Ryan, Magnus R. Dias da Silva, Tuck Wah Soong, Bertrand Fontaine, Matt R. Donaldson, Annie W.C. Kung, Wallaya Jongjaroenprasert, Mui Cheng Liang, Daphne H.C. Khoo, Jin Seng Cheah, Su Chin Ho, Harold S. Bernstein, Rui M.B. Maciel, Robert H. Brown, Louis J. Ptáček. Thyrotoxic hypokalemic periodic paralysis (TPP) is characterized by acute attacks of weakness, hypokalemia, and thyrotoxicosis of various etiologies. These transient attacks resemble those of pati.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153236 Fri, 08 Jan 2010 04:00:09 +0100 3153236 http://www.medworm.com/index.php?rid=3153235&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901558-X We report that eight heterozygous missense mutations in TUBB3, encoding the neuron-specific β-tubulin isotype III, result in a spectrum of human nervous system disorders that we now call th.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153235 Fri, 08 Jan 2010 04:00:09 +0100 3153235 http://www.medworm.com/index.php?rid=3153234&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901554-2 Salvatore Pece, Daniela Tosoni, Stefano Confalonieri, Giovanni Mazzarol, Manuela Vecchi, Simona Ronzoni, Loris Bernard, Giuseppe Viale, Pier Giuseppe Pelicci, Pier Paolo Di Fiore. Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the ba.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153234 Fri, 08 Jan 2010 04:00:09 +0100 3153234 http://www.medworm.com/index.php?rid=3153233&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901439-1 Daniel K. Nomura, Jonathan Z. Long, Sherry Niessen, Heather S. Hoover, Shu-Wing Ng, Benjamin F. Cravatt. Tumor cells display progressive changes in metabolism that correlate with malignancy, including development of a lipogenic phenotype. How stored fats are liberated and remodeled to support cancer .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153233 Fri, 08 Jan 2010 04:00:09 +0100 3153233 http://www.medworm.com/index.php?rid=3153232&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901614-6 Christina Kiel, Eva Yus, Luis Serrano. Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryoti.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153232 Fri, 08 Jan 2010 04:00:09 +0100 3153232 http://www.medworm.com/index.php?rid=3153231&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901624-9 Karun K. Singh, Li-Huei Tsai. The microtubule network is crucial for the developing nervous system, and mutations in tubulin-encoding genes disrupt neuronal migration. Tischfield et al. (2010) now report that mutations in the .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153231 Fri, 08 Jan 2010 04:00:09 +0100 3153231 http://www.medworm.com/index.php?rid=3153230&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901623-7 Jessica L. Yecies, Brendan D. Manning. Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153230 Fri, 08 Jan 2010 04:00:08 +0100 3153230 http://www.medworm.com/index.php?rid=3153229&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901621-3 Keara A. Franklin. Temperature is a key environmental signal regulating plant development, but the mechanisms by which plants sense small changes in ambient temperature have remained elusive. Kumar and Wigge (2010) .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153229 Fri, 08 Jan 2010 04:00:08 +0100 3153229 http://www.medworm.com/index.php?rid=3153228&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901622-5 Bruno Kyewski, Pärt Peterson. In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available fo.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153228 Fri, 08 Jan 2010 04:00:08 +0100 3153228 http://www.medworm.com/index.php?rid=3153227&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901615-8 William J. Holtz, Jay D. Keasling. Maximizing the production of a desired small molecule is one of the primary goals in metabolic engineering. Recent advances in the nascent field of synthetic biology have increased the predictabil.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153227 Fri, 08 Jan 2010 04:00:08 +0100 3153227 http://www.medworm.com/index.php?rid=3153226&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901620-1 Devin R. Burrill, Pamela A. Silver. The induction of a protracted response to a brief stimulus is a form of cellular memory. Here we describe the role of transcriptional regulation in both natural and synthetic memory networks and d.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153226 Fri, 08 Jan 2010 04:00:08 +0100 3153226 http://www.medworm.com/index.php?rid=3153225&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901625-0 Kris Novak. Ready or not, stem cells are a step closer to the clinic, thanks to ∼$230 million awarded by CIRM to 14 California-based research groups to develop stem cell-based therapies within 4 years. But, a.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153225 Fri, 08 Jan 2010 04:00:08 +0100 3153225 http://www.medworm.com/index.php?rid=3153224&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901634-1 Emilie Marcus. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153224 Fri, 08 Jan 2010 04:00:08 +0100 3153224 http://www.medworm.com/index.php?rid=3153223&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901637-7 In this issue, Leading Edge highlights synthetic biology, a field that is deepening our understanding of the design principles of life and increasing our mastery of biological systems for p.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153223 Fri, 08 Jan 2010 04:00:08 +0100 3153223 http://www.medworm.com/index.php?rid=3153222&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901631-6 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3153222 Fri, 08 Jan 2010 04:00:08 +0100 3153222 http://www.medworm.com/index.php?rid=3120314&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901505-0 Stefan Klumpp, Zhongge Zhang, Terence Hwa. Bacterial gene expression depends not only on specific regulatory mechanisms, but also on bacterial growth, because important global parameters such as the abundance of RNA polymerases and ribosom.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120314 Fri, 25 Dec 2009 04:00:08 +0100 3120314 http://www.medworm.com/index.php?rid=3120313&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901376-2 Harry H. Low, Carsten Sachse, Linda A. Amos, Jan Löwe. Proteins of the dynamin superfamily mediate membrane fission, fusion, and restructuring events by polymerizing upon lipid bilayers and forcing regions of high curvature. In this work, we show the .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120313 Fri, 25 Dec 2009 04:00:08 +0100 3120313 http://www.medworm.com/index.php?rid=3120312&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901438-X Patricia A.J. Muller, Patrick T. Caswell, Brendan Doyle, Marcin P. Iwanicki, Ee H. Tan, Saadia Karim, Natalia Lukashchuk, David A. Gillespie, Robert L. Ludwig, Pauline Gosselin, Anne Cromer, Joan S. Brugge, Owen J. Sansom, Jim C. Norman, Karen H. Vousden. p53 is a tumor suppressor protein whose function is frequently lost in cancers through missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 proteins .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120312 Fri, 25 Dec 2009 04:00:08 +0100 3120312 http://www.medworm.com/index.php?rid=3120311&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901437-8 Mi-Young Kim, Thordur Oskarsson, Swarnali Acharyya, Don X. Nguyen, Xiang H.-F. Zhang, Larry Norton, Joan Massagué. Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is thought that this is a unidirectional process. Here we show that circulating tumor cells (CTCs) can also .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120311 Fri, 25 Dec 2009 04:00:08 +0100 3120311 http://www.medworm.com/index.php?rid=3120310&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901507-4 Xiaohua Shen, Woojin Kim, Yuko Fujiwara, Matthew D. Simon, Yingchun Liu, Matthew R. Mysliwiec, Guo-Cheng Yuan, Youngsook Lee, Stuart H. Orkin. Trimethylation on histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) regulates the balance between self-renewal and differentiation of embryonic stem cells (ESCs). The mechani.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120310 Fri, 25 Dec 2009 04:00:08 +0100 3120310 http://www.medworm.com/index.php?rid=3120309&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901506-2 Jamy C. Peng, Anton Valouev, Tomek Swigut, Junmei Zhang, Yingming Zhao, Arend Sidow, Joanna Wysocka. Polycomb Repressive Complex 2 (PRC2) regulates key developmental genes in embryonic stem (ES) cells and during development. Here we show that Jarid2/Jumonji, a protein enriched in pluripotent cell.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120309 Fri, 25 Dec 2009 04:00:08 +0100 3120309 http://www.medworm.com/index.php?rid=3120308&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901501-3 Feng Wang, Wei Yang. E. coli DNA Pol II and eukaryotic Rev3 are B-family polymerases that can extend primers past a damaged or mismatched site when the high-fidelity replicative polymerases in the same family a.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120308 Fri, 25 Dec 2009 04:00:08 +0100 3120308 http://www.medworm.com/index.php?rid=3120307&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901500-1 Luciano A. Moreira, Iñaki Iturbe-Ormaetxe, Jason A. Jeffery, Guangjin Lu, Alyssa T. Pyke, Lauren M. Hedges, Bruno C. Rocha, Sonja Hall-Mendelin, Andrew Day, Markus Riegler, Leon E. Hugo, Karyn N. Johnson, Brian H. Kay, Elizabeth A. McGraw, Andrew F. van den Hurk, Peter A. Ryan, Scott L. O'Neill. Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosqu.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120307 Fri, 25 Dec 2009 04:00:08 +0100 3120307 http://www.medworm.com/index.php?rid=3120306&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901565-7 Sagi D. Shapira, Irit Gat-Viks, Bennett O.V. Shum, Amelie Dricot, Marciela M. de Grace, Liguo Wu, Piyush B. Gupta, Tong Hao, Serena J. Silver, David E. Root, David E. Hill, Aviv Regev, Nir Hacohen. During the course of a viral infection, viral proteins interact with an array of host proteins and pathways. Here, we present a systematic strategy to elucidate the dynamic interactions between H1.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120306 Fri, 25 Dec 2009 04:00:08 +0100 3120306 http://www.medworm.com/index.php?rid=3120305&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901564-5 Abraham L. Brass, I-Chueh Huang, Yair Benita, Sinu P. John, Manoj N. Krishnan, Eric M. Feeley, Bethany J. Ryan, Jessica L. Weyer, Louise van der Weyden, Erol Fikrig, David J. Adams, Ramnik J. Xavier, Michael Farzan, Stephen J. Elledge. Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of respiratory illness. In turn, the host expresses antiviral restriction factors to defend against infection. To.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120305 Fri, 25 Dec 2009 04:00:08 +0100 3120305 http://www.medworm.com/index.php?rid=3120304&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901555-4 James W. Dennis, Ivan R. Nabi, Michael Demetriou. Genetic information flows from DNA to macromolecular structures—the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosami.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120304 Fri, 25 Dec 2009 04:00:08 +0100 3120304 http://www.medworm.com/index.php?rid=3120303&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901560-8 Cheuk T. Leung, Joan S. Brugge. Circulating tumor cells are responsible for seeding metastatic growth at distant sites. Kim et al. (2009) now discover that circulating tumor cells can reinfiltrate tumors at their primary organs .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120303 Fri, 25 Dec 2009 04:00:08 +0100 3120303 http://www.medworm.com/index.php?rid=3120302&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901559-1 Michael Bandell, Ardem Patapoutian. The itch sensation results from the excitation of primary sensory nerve endings in the skin, but the underlying molecular mechanisms are not completely understood. Liu et al. (2009) now report tha.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120302 Fri, 25 Dec 2009 04:00:08 +0100 3120302 http://www.medworm.com/index.php?rid=3120301&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901553-0 George-Lucian Moldovan, Alan D. D'Andrea. Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper .... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120301 Fri, 25 Dec 2009 04:00:08 +0100 3120301 http://www.medworm.com/index.php?rid=3120300&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901563-3 Galina Selivanova, Johanna Ivaska. Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cel.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120300 Fri, 25 Dec 2009 04:00:08 +0100 3120300 http://www.medworm.com/index.php?rid=3120299&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901552-9 Zoltan Fehervari. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120299 Fri, 25 Dec 2009 04:00:08 +0100 3120299 http://www.medworm.com/index.php?rid=3120298&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901562-1 Takehito Furuyama, Steven Henikoff. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120298 Fri, 25 Dec 2009 04:00:08 +0100 3120298 http://www.medworm.com/index.php?rid=3120297&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901561-X Christophe Lavelle, Pierre Recouvreux, Hua Wong, Aurélien Bancaud, Jean-Louis Viovy, Ariel Prunell, Jean-Marc Victor. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120297 Fri, 25 Dec 2009 04:00:08 +0100 3120297 http://www.medworm.com/index.php?rid=3120296&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901567-0 Solomon H. Snyder. My professional life over five decades meandered from a high school ambition to be a psychiatrist and understand the “mind” to biochemical studies of neurotransmitters and drugs. Hopefully, the ta.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120296 Fri, 25 Dec 2009 04:00:08 +0100 3120296 http://www.medworm.com/index.php?rid=3120295&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901557-8 Martin Raff. The combination of human genetics, animal models, and induced pluripotent stem cells is likely to revolutionize our understanding of neuropsychiatric disorders, leading to new therapies and insigh.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120295 Fri, 25 Dec 2009 04:00:08 +0100 3120295 http://www.medworm.com/index.php?rid=3120294&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901551-7 Karen Dente. Far-reaching government reforms are being implemented to overhaul France's national research organizations in the life and health sciences, but researchers are anxious about what lies ahead. Karen.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120294 Fri, 25 Dec 2009 04:00:08 +0100 3120294 http://www.medworm.com/index.php?rid=3120293&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901566-9 Laura Vargas-Parada. In April this year, a new influenza virus of swine origin emerged in Mexico and spread rapidly around the world. As the Northern hemisphere winter flu season kicks off, Laura Vargas-Parada reports.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120293 Fri, 25 Dec 2009 04:00:07 +0100 3120293 http://www.medworm.com/index.php?rid=3120292&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901568-2 (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3120292 Fri, 25 Dec 2009 04:00:07 +0100 3120292 http://www.medworm.com/index.php?rid=3079152&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Ffulltext%2FS0092-8674%2809%2901498-6 Matthew N.J. Seaman. (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079152 Fri, 11 Dec 2009 04:00:09 +0100 3079152 http://www.medworm.com/index.php?rid=3079151&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901377-4 Mark Rebeiz, Margarita Ramos-Womack, Sangyun Jeong, Peter Andolfatto, Thomas Werner, John True, David L. Stern, Sean B. Carroll. We have shown previously that the loss of abdominal pigmentation in D. santomea relative to its sister species D. yakuba resulted, in part, from cis-regulatory mutations at th.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079151 Fri, 11 Dec 2009 04:00:09 +0100 3079151 http://www.medworm.com/index.php?rid=3079150&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901359-2 Daniel R. Matute, Ian A. Butler, Jerry A. Coyne. Previous work on Drosophila santomea suggested that its absence of abdominal pigmentation, compared to the other darkly pigmented species, is based on mutations in the cis-regulatory.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079150 Fri, 11 Dec 2009 04:00:09 +0100 3079150 http://www.medworm.com/index.php?rid=3079149&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901487-1 José Domingo Salazar, Treenut Saithong, Paul E. Brown, Julia Foreman, James C.W. Locke, Karen J. Halliday, Isabelle A. Carré, David A. Rand, Andrew J. Millar. Photoperiod sensors allow physiological adaptation to the changing seasons. The prevalent hypothesis is that day length perception is mediated through coupling of an endogenous rhythm with an exte.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079149 Fri, 11 Dec 2009 04:00:09 +0100 3079149 http://www.medworm.com/index.php?rid=3079148&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901426-3 Ehud Cohen, Johan F. Paulsson, Pablo Blinder, Tal Burstyn-Cohen, Deguo Du, Gabriela Estepa, Anthony Adame, Hang M. Pham, Martin Holzenberger, Jeffery W. Kelly, Eliezer Masliah, Andrew Dillin. The insulin/insulin growth factor (IGF) signaling (IIS) pathway is a key regulator of aging of worms, flies, mice, and likely humans. Delayed aging by IIS reduction protects the nematode C. ele.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079148 Fri, 11 Dec 2009 04:00:09 +0100 3079148 http://www.medworm.com/index.php?rid=3079147&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901374-9 Felicitas Müller, Nicola J. Mutch, Wolfdieter A. Schenk, Stephanie A. Smith, Lucie Esterl, Henri M. Spronk, Stefan Schmidbauer, William A. Gahl, James H. Morrissey, Thomas Renné. Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that activated platelets release inorganic polyphosphate (polyP), a polymer of 60–100 phosphate residues that dir.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079147 Fri, 11 Dec 2009 04:00:09 +0100 3079147 http://www.medworm.com/index.php?rid=3079146&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901433-0 N. Henriette Uhlenhaut, Susanne Jakob, Katrin Anlag, Tobias Eisenberger, Ryohei Sekido, Jana Kress, Anna-Corina Treier, Claudia Klugmann, Christian Klasen, Nadine I. Holter, Dieter Riethmacher, Günther Schütz, Austin J. Cooney, Robin Lovell-Badge, Mathias Treier. In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally responsible for triggering the indifferent gonads to develop as testes rather than ovaries. However, testis diffe.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079146 Fri, 11 Dec 2009 04:00:09 +0100 3079146 http://www.medworm.com/index.php?rid=3079145&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901375-0 Yi Ren, Calvin K. Yip, Arati Tripathi, David Huie, Philip D. Jeffrey, Thomas Walz, Frederick M. Hughson. Vesicle trafficking requires membrane fusion, mediated by SNARE proteins, and upstream events that probably include “tethering,” an initial long-range attachment between a vesicle and its target o.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079145 Fri, 11 Dec 2009 04:00:09 +0100 3079145 http://www.medworm.com/index.php?rid=3079144&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901434-2 Alexandra K. Gardino, Janice Villali, Aleksandr Kivenson, Ming Lei, Ce Feng Liu, Phillip Steindel, Elan Z. Eisenmesser, Wladimir Labeikovsky, Magnus Wolf-Watz, Michael W. Clarkson, Dorothee Kern. Phosphorylation is a common mechanism for activating proteins within signaling pathways. Yet, the molecular transitions between the inactive and active conformational states are poorly understood..... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079144 Fri, 11 Dec 2009 04:00:09 +0100 3079144 http://www.medworm.com/index.php?rid=3079143&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901432-9 Seogang Hyun, Jung Hyun Lee, Hua Jin, JinWu Nam, Bumjin Namkoong, Gina Lee, Jongkyeong Chung, V. Narry Kim. How body size is determined is a long-standing question in biology, yet its regulatory mechanisms remain largely unknown. Here, we find that a conserved microRNA miR-8 and its target, USH, regulat.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079143 Fri, 11 Dec 2009 04:00:09 +0100 3079143 http://www.medworm.com/index.php?rid=3079142&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901427-5 Cajetan Neubauer, Yong-Gui Gao, Kasper R. Andersen, Christine M. Dunham, Ann C. Kelley, Jendrik Hentschel, Kenn Gerdes, V. Ramakrishnan, Ditlev E. Brodersen. Translational control is widely used to adjust gene expression levels. During the stringent response in bacteria, mRNA is degraded on the ribosome by the ribosome-dependent endonuclease, RelE. The.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079142 Fri, 11 Dec 2009 04:00:09 +0100 3079142 http://www.medworm.com/index.php?rid=3079141&cid=s_32066_171_f&fid=32066&url=http%3A%2F%2Fwww.cell.com%2Fabstract%2FS0092-8674%2809%2901493-7 Christian P. Petersen, Peter W. Reddien. How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (.... (Source: Cell) Cell journals http://www.medworm.com/rss/comments.php?id=3079141 Fri, 11 Dec 2009 04:00:09 +0100 3079141