MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Cerebrospinal Fluid Research' source. Thu, 18 Mar 2010 14:49:25 +0100 http://www.medworm.com/index.php?rid=3264712&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F7%2F1%2F5 Conclusions: In iNPH patients, shunt response can be anticipated in 9/10 patients with elevated overnight ICP pulse amplitude, while in only 1/10 with low ICP pulse amplitude. Additionally, the CSFP pulse amplitude during lumbar infusion testing was elevated in patients with elevated over-night ICP pulse amplitude. In particular, measurement of CSFP pulse amplitude during a standardized infusion of 15 ml Ringer over 10 min was useful in predicting response to shunt surgery and can be used as a screening procedure for selection of iNPH patients for shunting. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3264712 Fri, 12 Feb 2010 00:00:00 +0100 3264712 http://www.medworm.com/index.php?rid=3256795&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F7%2F1%2F4 Conclusions: The data suggest that the impediment to lymphatic CSF absorption in a kaolin-induced model of communicating hydrocephalus has a significant impact on global CSF absorption. A lymphatic CSF absorption deficit would appear to play some role (either direct or indirect) in the pathogenesis of ventriculomegaly. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3256795 Wed, 10 Feb 2010 00:00:00 +0100 3256795 http://www.medworm.com/index.php?rid=3191271&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F7%2F1%2F3 Conclusion: These CSF rhythms are the first reports of sodium chronobiology in the human nervous system. The results are consistent with our hypothesis that rising levels of extracellular sodium may contribute to the timing of migraine onset. The physiological importance of sodium in the nervous system suggests that these rhythms may have additional repercussions on ultradian functions. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3191271 Wed, 20 Jan 2010 00:00:00 +0100 3191271 http://www.medworm.com/index.php?rid=3158586&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F7%2F1%2F2 Conclusion: Transcripts for hENT1-3 and hCNT3 were detected in human CP; mRNA for hENT3, an intracellularly located nucleoside transporter, was the most abundant. Human CP took up radiolabelled inosine by both concentrative and equilibrative processes. Concentrative uptake was probably mediated by hCNT3; the equilibrative uptake was mediated only by hENT2. The hENT1 transport activity was absent, which could suggest either that this protein was absent in the CP cells or that it was confined to the basolateral side of the CP epithelium. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3158586 Mon, 11 Jan 2010 00:00:00 +0100 3158586 http://www.medworm.com/index.php?rid=3187298&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com The cerebrospinal fluid (CSF) system functions to provide nutrients to and to remove waste products from the brain. Recent findings suggest, however, that in addition, the CSF contains message molecules in the form of actively released neuroactive substances. The concentrations of these are variable over time and between locations, suggesting they are important for the changes in brain activity that underlie different brain states, as reflected by different sensory input and behavioral output relationships.The cranial CSF displays a rapid caudally-directed ventricular flow followed by a slower rostrally-directed subarachnoid flow (mainly towards the cribriform plate and from there into the nasal lymphatics). Thus, many brain areas are exposed to and can be influenced by substances containe... Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3187298 Wed, 06 Jan 2010 00:00:00 +0100 3187298 http://www.medworm.com/index.php?rid=3147527&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F7%2F1%2F1 The cerebrospinal fluid (CSF) system functions to provide nutrients to and to remove waste products from the brain. Recent findings suggest, however, that in addition, the CSF contains message molecules in the form of actively released neuroactive substances. The concentrations of these are variable over time and between locations, suggesting they are important for the changes in brain activity that underlie different brain states, as reflected by different sensory input and behavioral output relationships.The cranial CSF displays a rapid caudally-directed ventricular flow followed by a slower rostrally-directed subarachnoid flow (mainly towards the cribriform plate and from there into the nasal lymphatics). Thus, many brain areas are exposed to and can be influenced by substances containe... Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3147527 Wed, 06 Jan 2010 00:00:00 +0100 3147527 http://www.medworm.com/index.php?rid=3131671&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com Conclusions: Infusing hyperosmolar solutions of dextran, or FGF into the ventricles chronically, resulted in ventricular enlargement. These solutions increase the osmotic load in the ventricles. Water influx (through the choroid plexus CSF secretion and/or through the brain) into the ventricles to normalize this osmotic gradient results in hydrocephalus. We need to revise the popular theory of how fluid accumulates in the ventricles at least in some forms of hydrocephalus. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3131671 Fri, 11 Dec 2009 00:00:00 +0100 3131671 http://www.medworm.com/index.php?rid=3077487&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F16 Conclusions: Infusing hyperosmolar solutions of dextran, or FGF into the ventricles chronically, resulted in ventricular enlargement. These solutions increase the osmotic load in the ventricles. Water influx (through the choroid plexus CSF secretion and/or through the brain) into the ventricles to normalize this osmotic gradient results in hydrocephalus. We need to revise the popular theory of how fluid accumulates in the ventricles at least in some forms of hydrocephalus. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3077487 Fri, 11 Dec 2009 00:00:00 +0100 3077487 http://www.medworm.com/index.php?rid=3006093&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F15 Conclusions: This study demonstrates that A2B receptor activation enhances ciliary beat frequency in lateral ventricle ependymal cells. Ependymal cell ciliary beat frequency regulation may play an important role in cerebral fluid balance and cerebral spinal fluid dynamics. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=3006093 Wed, 18 Nov 2009 00:00:00 +0100 3006093 http://www.medworm.com/index.php?rid=2997618&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F14 In a recent article, elevated cerebrospinal fluid pressure (CSFP) consistent with very early normal pressure hydrocephalus (NPH), was found in a small subset of Alzheimer's disease (AD) patients (possible AD-NPH hybrids) enrolled in a clinical trial for chronic low-flow cerebrospinal fluid drainage. Also in the same study, was another interesting finding that merits further discussion: a substantial proportion of AD patients had very low CSFP. Based on the characteristics of these subjects, we hypothesize that more advanced AD may be associated with a decrease in CSFP. Reduced CSFP among a group of AD patients could provide a clue towards a better understanding of the high rate of comorbidity reported between AD and glaucoma since it has been shown that mean CSFP is lower in subjects with ... Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2997618 Mon, 16 Nov 2009 00:00:00 +0100 2997618 http://www.medworm.com/index.php?rid=2949308&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F13 Conclusions: In this preliminary proof-of-concept study, a rapid diagnosis of TBM could be achieved using LAM antigen detection. Although specificity was sub-optimal, the estimates provided here may be unreliable because of a classification bias inherent in the study design where it was not possible to exclude TBM in the presumed non-TBM cases owing to a lack of clinical follow-up. As PCR is largely unavailable, the LAM assay may well prove to be a useful adjunct for the rapid diagnosis of TBM in high HIV-incidence settings. These preliminary results justify further enquiry and prospective studies are now required to definitively establish the place of this technology for the diagnosis of TBM. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2949308 Mon, 02 Nov 2009 00:00:00 +0100 2949308 http://www.medworm.com/index.php?rid=2773577&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F10 Conclusions Unique morphology and biochemistry features of abundant and discrete membrane-bound CSF nanostructures are described. Prostaglandin H synthase activity, essential for prostanoid production and previously unknown in CSF, is localized to nanospheres. Considering CSF bulk flow and its circulatory dynamics, we propose that these nanostructures provide signaling mechanisms via volume transmission within the nervous system that are for slower, more diffuse, and of longer duration than synaptic transmission. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2773577 Sun, 06 Sep 2009 23:00:00 +0100 2773577 http://www.medworm.com/index.php?rid=2669340&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F9 Background: Sheep are seasonal breeders. The key factor governing seasonal changes in the reproductive activity of the ewe is increased negative feedback of estradiol at the level of the hypothalamus under long-day conditions. It has previously been demonstrated that when gonadotropin secretions are inhibited during long days, there is a higher concentration of estradiol in the cerebrospinal fluid (CSF) than during short days. This suggests an involvement of the CSF and choroid plexus in the neuroendocrine regulatory loop, but the mechanisms underlying this phenomenon remain unknown. One possible explanation of this difference in hormonal content is an effect of concentration or dilution caused by variations in CSF secretion rate. The aim of this study was thus to investigate changes in th... Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2669340 Mon, 03 Aug 2009 23:00:00 +0100 2669340 http://www.medworm.com/index.php?rid=2565580&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F8 Conclusions: The C 4 Reibergram can be used to quantify the intrathecal synthesis of this component of the complement system in different infectious diseases of the central nervous system and is especially useful for patients with blood-brain barrier dysfunction. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2565580 Wed, 01 Jul 2009 23:00:00 +0100 2565580 http://www.medworm.com/index.php?rid=2492069&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F7 Conclusion: Removal of the fibrous band and the outer dural layer, at level of foramen magnum, together with the incision of inner dural layer seems to be good technique in adult CMI patients. Advantages are short operation time, no need for duraplasty, sufficient posterior fossa decompression, absence of CSF fistulas as a result of extraarachnoidal working, and short duration of hospitalization. Hence this surgical technique has advantages compared to other techniques. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2492069 Sun, 21 Jun 2009 23:00:00 +0100 2492069 http://www.medworm.com/index.php?rid=2444428&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F6 Conclusions: Assessment of attention functions in children with SBM by traditional tests may be misleading, because this paediatric population with complex cerebral malformations has difficulty with the cognitive and visual-motor requirements. To control for these interactions, the use of both traditional and computerized attention tests is recommended. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2444428 Thu, 28 May 2009 04:00:00 +0100 2444428 http://www.medworm.com/index.php?rid=2437993&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F5 Conclusions: The results suggest that needle size, at least for 22-25G, does not affect the results of RI cisternographic diagnostic tests for CSF leakage in intracranial hypotension. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2437993 Wed, 27 May 2009 04:00:00 +0100 2437993 http://www.medworm.com/index.php?rid=2434668&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F4 Conclusions: Neonatal rats with and without hydrocephalus had low expression of Abeta and its transporters when compared to adult rats with hydrocephalus. No statistical differences were observed in Abeta and its transporters between the control and hydrocephalic neonatal animals. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2434668 Tue, 26 May 2009 04:00:00 +0100 2434668 http://www.medworm.com/index.php?rid=2278793&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F6%2F1%2F3 Conclusion: This study has demonstrated that the cold sensation receptor channel, TRPM8, is localised within the dCSF-CNs of the mesencephalon. TRPM8 acts as receptor of dCSF-CNs for sensation transmission and pain regulation. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2278793 Tue, 17 Mar 2009 04:00:00 +0100 2278793 http://www.medworm.com/index.php?rid=2222005&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F21 Conclusion: Independent of the pathogenesis, neonatal HPHC is associated with the activation of the pro-inflammatory cytokines (IL-18 and IFNγ) in the CSF, whereas CSF apoptosis biomarkers (sFasL) were unchanged. This suggests that anti-inflammatory treatment (in addition to shunting) could be helpful to preserve cerebral white matter. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2222005 Wed, 31 Dec 2008 05:00:00 +0100 2222005 http://www.medworm.com/index.php?rid=2073336&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F21 Conclusion: Independent of the pathogenesis, neonatal HPHC is associated with the activation of the pro-inflammatory cytokines (IL-18 and IFNgamma) in the CSF, whereas CSF apoptosis biomarkers (sFasL) were unchanged. This suggests that anti-inflammatory treatment (in addition to shunting) could be helpful to preserve cerebral white matter. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2073336 Wed, 31 Dec 2008 05:00:00 +0100 2073336 http://www.medworm.com/index.php?rid=2073337&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F20 Conclusion: Fgf2 expression early in the development of both human and rodent choroid plexus, and its ability to modulate behaviour and gene expression in CPe, supports the view that Fgf signalling plays a role in the maintenance of integrity and function of this specialized epithelium, and that this role is conserved between rodents and humans. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2073337 Mon, 29 Dec 2008 05:00:00 +0100 2073337 http://www.medworm.com/index.php?rid=2059870&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F18 Conclusion: Intrathecal synthesis of IgE demonstrates the participation of this immunoglobulin in the destruction of the third stage larvae of the parasite in the CSF. The test should be considered in our environment as a tool to aid diagnosis. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=2059870 Tue, 25 Nov 2008 05:00:00 +0100 2059870 http://www.medworm.com/index.php?rid=1933758&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F17 Conclusion: Shunt infection was established in the canine model, and had the experiment been extended beyond four weeks the typical microbiological, pathological and clinical features might have appeared. The occurrence of unplanned shunt infections in control animals due to canine normal skin flora reflects human clinical experience and underlines the usual source of bacteria causing shunt infection. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1933758 Fri, 24 Oct 2008 04:00:00 +0100 1933758 http://www.medworm.com/index.php?rid=1905278&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F17 Conclusions: Shunt infection was established in the canine model, and had the experiment been extended beyond four weeks the typical microbiological, pathological and clinical features might have appeared. The occurrence of unplanned shunt infections in control animals due to canine normal skin flora reflects human clinical experience and underlines the usual source of bacteria causing shunt infection. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1905278 Fri, 24 Oct 2008 04:00:00 +0100 1905278 http://www.medworm.com/index.php?rid=1704509&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F13 This report highlights a conference designed for patient education on elevated cerebrospinal fluid (CSF) pressure. The conference centered on chronic intracranial hypertension (IH) including the latest research and clinical information. It was sponsored by the Intracranial Hypertension Research Foundation and held at the University of Texas Medical School, Houston, on June 21-22nd, 2008. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1704509 Wed, 13 Aug 2008 04:00:00 +0100 1704509 http://www.medworm.com/index.php?rid=1400132&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F9 Conclusions: We conclude that a number of biochemical changes occur after shunt surgery, but there are no marked differences between the SNPH and INPH patients. The results indicate that NFL may be a marker that can predict a surgically reversible state in NPH. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1400132 Fri, 25 Apr 2008 04:00:00 +0100 1400132 http://www.medworm.com/index.php?rid=1388619&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F8 Conclusion: The Polaris Valve is a reliable, adjustable valve. Unlike other adjustable valves (except the Miethke ProGAV valve), the Polaris cannot be accidentally re-adjusted by an external magnetic field. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1388619 Mon, 21 Apr 2008 04:00:00 +0100 1388619 http://www.medworm.com/index.php?rid=1366511&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F7 This review is a modified version of the Casey Holter Memorial prize essay presented to the Society for Research into Hydrocephalus and Spina Bifida, June 29th 2007, Heidelberg, Germany. It describes the origin and consequences of the Chiari malformation, and proposes that hydrocephalus is caused by inadequate central nervous system (CNS) venous drainage. A new hypothesis regarding the pathogenesis, anencephaly and spina bifida is described. Any volume increase in the central nervous system can increase venous pressure. This occurs because veins are compressible and a CNS volume increase may result in reduced venous blood flow. This has the potential to cause progressive increase in cerebrospinal fluid (CSF) volume. Venous insufficiency may be caused by any disease that reduces space for... Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1366511 Fri, 11 Apr 2008 04:00:00 +0100 1366511 http://www.medworm.com/index.php?rid=1277511&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F5 Conclusions: The rat choroidal tissue has a significant ability to metabolize PGE2 during early postnatal life. This metabolic activity may participate in signal termination of centrally released PGE2 in the brain, or function as an enzymatic barrier acting to maintain PGE2 homeostasis in CSF during the critical early postnatal period of brain development. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1277511 Tue, 04 Mar 2008 05:00:00 +0100 1277511 http://www.medworm.com/index.php?rid=1270984&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F4 Conclusions: In fetal SBA, neuroepithelial/ependymal denudation in the telencephalon and the aqueduct can occur before Chiari II malformation and/or hydrocephalus. Since denuded areas cannot re-establish cell function, neuro-developmental consequences could induce permanent cerebral pathology. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1270984 Sat, 01 Mar 2008 05:00:00 +0100 1270984 http://www.medworm.com/index.php?rid=1175954&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F3 Conclusions: It is concluded that (i) during the late embryonic life, the rat SCO secretes compounds that remain soluble in the CSF and reach the subarachnoid space; (ii) during postnatal life, there is a reduction in the number and concentration of CSF-soluble proteins secreted by the SCO. The molecular structure and functional significance of these proteins remain to be elucidated. The possibility they are involved in brain development has been discussed. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1175954 Thu, 24 Jan 2008 05:00:00 +0100 1175954 http://www.medworm.com/index.php?rid=1169242&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F5%2F1%2F2 The aim of this review is to refine the definition and classification of hydrocephalus as a preview to developing an international consensus on the nomenclature of this complex condition. This proposed definition and classification is based on my own work in this area and is intended to promote a debate on the concepts presented. A literature review of contemporary definitions and classifications of hydrocephalus, and of the historic context in which these concepts developed, is presented. Based on new technology and understanding of hydrocephalus, the rationale for nomenclature is also discussed. Currently, there is no recognized definition of hydrocephalus. The failure to agree on a working definition impedes progress in understanding the pathophysiology and treatment of hydrocephalus. T... Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1169242 Tue, 22 Jan 2008 05:00:00 +0100 1169242 http://www.medworm.com/index.php?rid=1118926&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F11 Conclusion: The three CP cell lines analyzed in this study vary considerably with regard to the expression of AJ and TJ proteins, which is likely reflected by different barrier properties of these in vitro models of BCSFB. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=1118926 Thu, 27 Dec 2007 05:00:00 +0100 1118926 http://www.medworm.com/index.php?rid=902635&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F9 Conclusions: Kaolin predictably produces moderate to severe hydrocephalus with a mild chronic inflammatory reaction and fibrosis of the leptomeninges. Other synthetic polymers and biopolymers tested are unreliable and cause different types of inflammation. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=902635 Tue, 25 Sep 2007 04:00:00 +0100 902635 http://www.medworm.com/index.php?rid=796890&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F7 Conclusion: Clinical motor signs of NPH subjects extend beyond gait deficits and include extrapyramidal manifestations of bradykinesia, akinesia, rigidity, and propensity to perform more poorly when external cues to move are absent. Objective improvement of some but not all of these features was seen following temporary or permanent CSF diversion. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=796890 Mon, 13 Aug 2007 04:00:00 +0100 796890 http://www.medworm.com/index.php?rid=737421&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F6 Conclusions: The data obtained on the spatial distribution and en face surface area of AGs will be used in an in vitro model of CSF outflow. With an increase in the number of samples, this analysis technique can be used to study the relationship between AG surface area and variables such as age, race and gender. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=737421 Mon, 16 Jul 2007 04:00:00 +0100 737421 http://www.medworm.com/index.php?rid=672092&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F5 Conclusions: Overall, these results suggest that reactive astrocytosis and microgliosis are associated with progressive untreated ventriculomegaly, but that shunt treatment can reduce the gliosis occurring with hydrocephalus. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=672092 Thu, 07 Jun 2007 04:00:00 +0100 672092 http://www.medworm.com/index.php?rid=556853&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F4 A report of a meeting sponsored by the BrainChild Foundation on the challenges for hydrocephalus researchers to provide the information required for better management of cerebrospinal fluid disorders. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=556853 Thu, 19 Apr 2007 04:00:00 +0100 556853 http://www.medworm.com/index.php?rid=502002&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F2 Conclusion: Patients, carers and professionals should be warned that pumping a shunts prechamber may cause a large change in intracranial pressure and predispose the patient to ventricular catheter obstruction or other complications. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=502002 Mon, 26 Mar 2007 04:00:00 +0100 502002 http://www.medworm.com/index.php?rid=389243&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F1 This book on cerebrospinal fluid (CSF) proteins is primarily focused on immunoglobulins. The book was written as an extension of a meeting on multiple sclerosis to provide a more extensive consideration of the CSF. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=389243 Fri, 26 Jan 2007 07:00:00 +0100 389243 http://www.medworm.com/index.php?rid=456476&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F4%2F1%2F1 This book on cerebrospinal fluid (CSF) proteins is primarily focused on immunoglobulins. The book was written as an extension of a meeting on multiple sclerosis to provide a more extensive consideration of the CSF. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=456476 Fri, 26 Jan 2007 05:00:00 +0100 456476 http://www.medworm.com/index.php?rid=379686&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F3%2F1%2F14 Conclusion: Patients with sensory deficit, memory problems, and Arnold Chiari malformation had a higher risk of having pressure sores. This patient group needs improved skin inspection routines and sore treatment. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=379686 Fri, 29 Dec 2006 07:00:00 +0100 379686 http://www.medworm.com/index.php?rid=379687&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F3%2F1%2F13 Conclusion: It was demonstrated that CP epithelium can be isolated and cultured, with cells growing into intact monolayers, fully differentiating and with properties resembling the tissue in vivo. Thus, the established primary porcine CP model, allowing investigation of complex transport processes, can be used as a reliable tool for analysis of xenobiotic transport across the blood-cerebrospinal fluid barrier (BCSFB). (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=379687 Thu, 21 Dec 2006 07:00:00 +0100 379687 http://www.medworm.com/index.php?rid=379688&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F3%2F1%2F12 This multi-author volume on the blood-cerebrospinal fluid barrier summarizes past and current research in the areas of choroid plexus and cerebrospinal fluid in health and disease. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=379688 Fri, 08 Dec 2006 07:00:00 +0100 379688 http://www.medworm.com/index.php?rid=379689&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F3%2F1%2F11 Awareness of the importance of chronic adult hydrocephalus has been raised again with the recent emergence of epidemiological studies. It is estimated that between 5 and 10% of patients suffering from dementia might, in fact, have chronic hydrocephalus. Although, surgical diversion of the cerebrospinal fluid (CSF) represents the only known procedure able to treat the symptoms of this condition, the selection of surgical patients has always been problematic. In the last 40 years, we have become wiser in using appropriate diagnostic tests for the selection of these patients; however, the area of biological markers has so far been overlooked in this condition, in contrast to that for other neurodegenerative disorders and dementias. Biomarkers are biological substances that may be used to indi... Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=379689 Wed, 04 Oct 2006 06:00:00 +0100 379689 http://www.medworm.com/index.php?rid=379690&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F3%2F1%2F7 Conclusion: Of the AD subjects who were carefully screened to exclude those with clinical NPH, 4% had elevated CSFP. These subjects were presumed to have the AD-NPH syndrome and were withdrawn from the remainder of the study. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=379690 Wed, 31 May 2006 06:00:00 +0100 379690 http://www.medworm.com/index.php?rid=379691&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F3%2F1%2F6 A review of the book 'Neural Tube Defects - From Origin to Treatment' (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=379691 Mon, 03 Apr 2006 06:00:00 +0100 379691 http://www.medworm.com/index.php?rid=379692&cid=s_34058_25_f&fid=34058&url=http%3A%2F%2Fwww.cerebrospinalfluidresearch.com%2Fcontent%2F3%2F1%2F5 Conclusion: This study demonstrated that ADA activity in the CSF of TBM patients, using a cut-off value 11.39 U/L/min, can be useful for the early differential diagnosis of TBM. This test can be performed in any pathology laboratory where more sophisticated methods are not available. (Source: Cerebrospinal Fluid Research) Cerebrospinal Fluid Research journals http://www.medworm.com/rss/comments.php?id=379692 Thu, 30 Mar 2006 07:00:00 +0100 379692