MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Chemistry and Biodiversity' source. Thu, 09 Feb 2012 13:38:32 +0100 http://www.medworm.com/index.php?rid=5621444&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253098%26dopt%3DAbstract Authors: Wang H, Li MY, Wu J Abstract In this review, the literature data on phytochemical and biological investigations of the genus Ceriops are compiled. The Ceriops species are mangrove plants widely distributed along the sea coasts of Africa, Madagascar, South Asia, and South Pacific islands. To date, 43 diterpenes and 29 triterpenes have been reported from the embryos, fruits, hypocotyls, roots, stems, and twigs of C. tagal and C. decandra. Diterpenoids and triterpenoids are the main constituents of this genus. The isolated terpenes showed an enormous structural diversity and exhibited various biological properties, such as antitumor, antibacterial, and larvicidal activities. PMID: 22253098 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621444 Sun, 01 Jan 2012 05:00:00 +0100 5621444 http://www.medworm.com/index.php?rid=5621443&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253099%26dopt%3DAbstract Authors: Cecchini C, Silvi S, Cresci A, Piciotti A, Caprioli G, Papa F, Sagratini G, Vittori S, Maggi F Abstract The aim of this study was to verify the effectiveness of Achillea ligustica essential oils against several oral microorganisms in comparison with a commercial essential oil-containing mouthrinse (Listerine(®) ) and clove oil (containing 89% eugenol). The inhibition efficacy of A. ligustica essential oils alone and in combination with Listerine(®) was evaluated by the micro-dilution method. The most susceptible microorganisms were Bacillus cereus, Streptococcus pyogenes, and Candida albicans. The efficacy was similar to that of the clove oil. The antiseptic mouthwash Listerine(®) did not exert a strong inhibition on microbial strains tested, whereas its effectiveness i... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621443 Sun, 01 Jan 2012 05:00:00 +0100 5621443 http://www.medworm.com/index.php?rid=5621442&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253100%26dopt%3DAbstract Authors: Ruiz-Bermejo M, de la Fuente JL, Rogero C, Menor-Salván C, Osuna-Esteban S, Martín-Gago JA Abstract The data presented here provide a novel contribution to the understanding of the structural features of HCN polymers and could be useful in further development of models for prebiotic chemistry. The interpretation of spectroscopic and analytical data, along with previous results reported by other authors, allowed us to propose a mechanism for the aqueous polymerization of HCN from its primary and simplest isolated oligomer, the diaminomaleonitrile (DAMN) tetramer. We suggest that 'insoluble black HCN polymers' are formed by an unsaturated complex matrix, which retains a significant amount of H(2) O and important bioorganic compounds or their precursors. This polymeric matr... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621442 Sun, 01 Jan 2012 05:00:00 +0100 5621442 http://www.medworm.com/index.php?rid=5621441&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253101%26dopt%3DAbstract Authors: Chakor JN, Musso L, Sardi P, Dallavalle S Abstract A series of analogs of the natural antifungal compound crassinervic acid, a constituent of Piper crassinervium, were synthesized to gain insight into the most relevant structural features affecting the activity of the parent molecule. Most compounds were prepared by aldol reaction of methyl 3-acetyl-4-hydroxybenzoate with a series of ketones, followed by reduction, hydrolysis, and oxidation. The antifungal activities of crassinervic acid and its analogs was assessed against Cladosporium cladosporioides by using the method of bioautography. The bioassay results allowed us to depict structureactivity relationships for this class of compounds. PMID: 22253101 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621441 Sun, 01 Jan 2012 05:00:00 +0100 5621441 http://www.medworm.com/index.php?rid=5621440&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253102%26dopt%3DAbstract Authors: Matysiak J, Karpińska MM, Niewiadomy A, Wietrzyk J, Kłopotowska D Abstract A one-pot synthesis of new 4-(1,3-thiazolo[5,4-b]pyridin-2-yl)benzene-1,3-diols has been described. The compounds were prepared by the reaction of sulfinylbis[(2,4-dihydroxyphenyl)methanethione] derivatives, with various substituents in the aryl rings, with 2-chloropyridin-3-amines. Their structures were deduced from IR and, (1) H- and (13) C-NMR spectroscopic, mass spectrometric, and elemental analyses. The antiproliferative properties of some of the products against human cancer cell lines were comparable to those of cisplatin. Structureactivity analysis showed that the presence of hydrophobic substituents in both heterocyclic fused and phenyl rings of the compounds improves their biological ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621440 Sun, 01 Jan 2012 05:00:00 +0100 5621440 http://www.medworm.com/index.php?rid=5621439&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253103%26dopt%3DAbstract Authors: Adão CR, Pereira da Silva B, Tinoco LW, Parente JP Abstract A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum L. var. porrum. On the basis of chemical evidence, comprehensive spectroscopic analyses, and comparison with known compounds, its structure was established as (3β,5α,6β,25R)-3-{(O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2)-O-[O-β-D-glucopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy}-6-hydroxyspirostan-2-one (1). Results of the present study indicated that 1 exhibited haemolytic activity in the in vitro assays, and immunological adjuvant activity on the cellular immune response against ovalbumin antigen. PMID: 22253103 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621439 Sun, 01 Jan 2012 05:00:00 +0100 5621439 http://www.medworm.com/index.php?rid=5621438&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253104%26dopt%3DAbstract Authors: Dong Y, Shi H, Yang H, Peng Y, Wang M, Li X Abstract The EtOH extract of the stems of Entada phaseoloides displayed potent antioxidant activity when assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging, reducing power, β-carotene-bleaching, and superoxide radical-scavenging analyses. Fractionation of the EtOH extracts showed that the AcOEt fraction is the most active, followed by the H(2) O fraction, while BuOH fraction was least active. Further activity-guided fractionation studies on the active fractions resulted in the isolation of 22 compounds. The identities of these compounds were established based on extensive spectroscopic studies. Furthermore, the antioxidant activities of the iso... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621438 Sun, 01 Jan 2012 05:00:00 +0100 5621438 http://www.medworm.com/index.php?rid=5621437&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253105%26dopt%3DAbstract Authors: Nikolić B, Tešević V, Dordđević I, Todosijević M, Jadranin M, Bojović S, Marin PD Abstract This is the first report of individual variability and population diversity of the contents of nonacosan-10-ol and n-alkanes in the needle cuticular waxes of Bosnian pines originated from Montenegro, regarded as Pinus heldreichii var. leucodermis, and from Serbia, regarded as P. heldreichii var. pančići. The amount of nonacosan-10-ol varied individually from 27.4 to 73.2% (55.5% in average), but differences between the four investigated populations were not statistically confirmed. The size of the n-alkanes ranged from C(18) to C(33) . The most abundant n-alkanes were C(23) , C(27) , and C(25) (12.2, 11.2, and 10.8% in average, resp.). The carbon preference index (CPI) of th... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621437 Sun, 01 Jan 2012 05:00:00 +0100 5621437 http://www.medworm.com/index.php?rid=5621435&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253106%26dopt%3DAbstract Authors: Siddiq F, Fatima I, Malik A, Afza N, Iqbal L, Lateef M, Hameed S, Khan SW Abstract New bergenin derivatives, bergecins A and B (1 and 2, resp.), have been isolated from the AcOEt-soluble fraction of Bergenia stracheyi, along with bergenin (3), and their structures were elucidated on the basis of (1) H- and (13) C-NMR spectra, and by COSY, HMQC, and HMBC experiments. Compound 2 showed potent inhibitory potential against the enzyme lipoxygenase, while 1 was moderately active. On the other hand, both compounds exhibited significant antioxidant activities in 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay. PMID: 22253106 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621435 Sun, 01 Jan 2012 05:00:00 +0100 5621435 http://www.medworm.com/index.php?rid=5621434&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253107%26dopt%3DAbstract Authors: Ting CW, Hwang TL, Chen IS, Yen MH, Chen JJ Abstract A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC(50) values of 7.21±1.07 and 6.01±0.37 μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively. PMID: 22253107 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621434 Sun, 01 Jan 2012 05:00:00 +0100 5621434 http://www.medworm.com/index.php?rid=5621433&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253108%26dopt%3DAbstract Authors: Radulović N, Dekić M, Joksović M, Vukićević R Abstract The volatile constituents of Teucrium scordium L. ssp. scordioides, T. polium, and T. montanum, obtained by hydrodistillation, were investigated by GC-FID and GC/MS analyses. A total of 296 constituents were identified, representing 89.8-98.4% of the oil compositions. The oils of T. polium and T. montanum consisted mainly of sesquiterpenes (64.3 and 72.7%, resp.), with germacrene D (4; 31.0%) and δ-cadinene (10; 8.1%) as the main constituents, respectively. In contrast, the monoterpene menthofuran (1; 11.9%) predominated in the oil of T. scordium ssp. scordioides, and this clearly distinguished this species from the other Teucrium taxa investigated up to date. The chemistry of the volatiles of eight Teucrium taxa... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621433 Sun, 01 Jan 2012 05:00:00 +0100 5621433 http://www.medworm.com/index.php?rid=5621432&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253109%26dopt%3DAbstract Authors: Tian LW, Xu M, Li Y, Li XY, Wang D, Zhu HT, Yang CR, Zhang YJ Abstract Three new phenolic compounds, eucalmaidin F (1), (3S)-5-guaiacyl-3-hydroxypentanoic acid (2), and 8-β-C-glucopyranosyl-5,7-dihydroxy-2-isobutylchromone (3), were isolated from the branches of E. maideni, together with 30 known compounds, including four phenylpropanoids, three lignans, four phloroglucinol glucosides, five dihydroflavonoids, seven simple phenolic compounds, six terpenoids, and glycerol. The new structures were established by spectroscopic studies (MS, and 1D- and 2D-NMR), chemical degradation, and modified Mosher's method. Compounds 3, guaiacylglycerol, 3-hydroxy-1-(4-hydroxyphenyl)propan-1-one, caffeic acid, (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid, (7'S,8R,8'R)-lyoniresinol, (+)-lyo... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621432 Sun, 01 Jan 2012 05:00:00 +0100 5621432 http://www.medworm.com/index.php?rid=5621430&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253110%26dopt%3DAbstract Authors: Wang GJ, Liang WL, Ju YM, Yang WB, Chang YW, Lee TH Abstract A series of six isopimarane-type diterpene glycosides, along with an eremophilane-type sesquiterpene, i.e., elaeicolasides A-C (1-3, resp.), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (4), hymatoxin K (5), hymatoxin L (6), and elaeicolalactone (7), were isolated from the AcOEt extract of the fermented broth of Stilbohypoxylon elaeicola YMJ173. Among these, 1-3 and 7 are new compounds based on their spectroscopic data and sugar composition analysis. The effects of 1-7 on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were evaluated. All these compounds inhibited NO production, detected as nitrite in the culture medium, in activated ma... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621430 Sun, 01 Jan 2012 05:00:00 +0100 5621430 http://www.medworm.com/index.php?rid=5621429&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253111%26dopt%3DAbstract Authors: Kpadonou Kpoviessi BG, Ladekan EY, Kpoviessi DS, Gbaguidi F, Yehouenou B, Quetin-Leclercq J, Figueredo G, Moudachirou M, Accrombessi GC Abstract To determine the period of harvest that optimizes the antimicrobial activities of the essential oil of Ocimum gratissimum L. from Benin, aerial plant parts were collected at two vegetative stages (pre- and full-flowering) and three sampling times (7 am, 1 pm, and 7 pm). Extraction by hydrodistillation yielded between 0.65 and 0.78% of essential oils. Characterization of the oils by GC-FID and GC/MS analysis revealed the presence of monoterpenes (87.26-93.81%), sesquiterpenes (5.57-11.34%), and aliphatic compounds (0.15-0.18%), with p-cymene (1; 28.08-53.82%), thymol (2; 3.32-29.13%), γ-terpinene (3; 1.11-10.91%), α-thujene... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621429 Sun, 01 Jan 2012 05:00:00 +0100 5621429 http://www.medworm.com/index.php?rid=5621428&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253112%26dopt%3DAbstract In this study, we analyzed the chemical composition of volatile oils hydrodistilled from seeds of Consolida regalis, Delphinium elatum, Nigella hispanica, and N. nigellastrum using GC and GC/MS. In C. regalis, octadecenoic (77.79%) and hexadecanoic acid (8.34%) were the main constituents. Similarly, the oils from D. elatum and N. hispanica seeds consisted chiefly of octadecadienoic (42.83 and 35.58%, resp.), hexadecanoic (23.87 and 28.59%, resp.), and octadecenoic acid (21.67 and 19.76%, resp.). Contrastingly, the monoterpene hydrocarbons α-pinene (34.67%) and β-pinene (36.42%) were the main components of N. nigellastrum essential oil. Our results confirm the presence of essential oils in the family Ranunculaceae and suggest chemotaxonomical relationships within the representatives of th... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621428 Sun, 01 Jan 2012 05:00:00 +0100 5621428 http://www.medworm.com/index.php?rid=5621427&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253113%26dopt%3DAbstract Authors: Chang LS, Li CB, Qin N, Jin MN, Duan HQ Abstract In a study to evaluate the structural elements essential for the antidiabetic activity of flavonoids, we synthesized two series of flavonoids, 5,7-dihydroxyflavanones and 5,7-dihydroxyflavones. In a screening for potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 1f, 2d, and 3c were significantly more effective than the positive control, metformin. The biological activity was mainly affected by structural modification at the ring B moiety of the flavonoid skeleton. The results suggest that 5,7-dihydroxyflavonoids can be considered as promising candidates in the development of new antidiabetic lead compounds. PMID: 22253113 [PubMed - in process] (Source: Chemistry ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621427 Sun, 01 Jan 2012 05:00:00 +0100 5621427 http://www.medworm.com/index.php?rid=5621426&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253114%26dopt%3DAbstract In this report, we present the preliminary investigation on the relationship between the structure and function of DNAzymes through a terminal oligo modification in G-quadruplex sequences by adding different lengths of oligo-dT to the 3'- or 5'-end of the aptamers. The results suggested that adding dT(n) to the 5'-end of the DNA sequence of the enzyme improved the ability of hemin to bind with DNA, but the addition of dT(n) to the 3'-end decreased the binding ability of hemin for DNA. The increased stability of the assembled DNAzyme would lead to more favorable binding between the enzyme and substrate (H(2) O(2) ), facilitating higher peroxidase activity; on the contrary, with lower stability of the DNAzyme complex, we observed reduced peroxidase activity. PMID: 22253114 [PubMed - in p... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621426 Sun, 01 Jan 2012 05:00:00 +0100 5621426 http://www.medworm.com/index.php?rid=5621425&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253115%26dopt%3DAbstract Authors: PMID: 22253115 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5621425 Sun, 01 Jan 2012 05:00:00 +0100 5621425 http://www.medworm.com/index.php?rid=5513285&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162156%26dopt%3DAbstract Authors: Barbosa LF, Braz-Filho R, Vieira IJ PMID: 22162156 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513285 Thu, 01 Dec 2011 05:00:00 +0100 5513285 http://www.medworm.com/index.php?rid=5513284&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162157%26dopt%3DAbstract Authors: Giuliani C, Maleci Bini L, Papa F, Cristalli G, Sagratini G, Vittori S, Lucarini D, Maggi F Abstract Sideritis italica (Mill.) Greuter et Burdet belongs to the Lamiaceae family and is endemic to Italy. The glandular trichomes (morphology, distribution, histochemistry, and ultrastructure) of the plant were studied for the first time, along with the chemical composition of the essential oils. Abundant non-glandular hairs and peltate (type A) and capitate (types B, C(1) , and C(x) ) glandular trichomes were observed both on the vegetative and reproductive organs. The histochemical procedures and the ultrastructural investigation enabled specific location of the main site of essential oil production mainly in type-A peltate hairs. Particular emphasis is given to the release me... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513284 Thu, 01 Dec 2011 05:00:00 +0100 5513284 http://www.medworm.com/index.php?rid=5513283&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162158%26dopt%3DAbstract Authors: Woll KA, Schuchardt EJ, Willis CR, Ortengren CD, Hendricks N, Johnson M, Gaidamauskas E, Baruah B, Sostarecz AG, Worley DR, Osborne DW, Crans DC Abstract The interaction of amphiphilic molecules such as lipids and surfactants with the hydrophilic drug carboplatin was investigated to identify suitable self-assembling components for a potential gel-based delivery formulation. (1) H-NMR Studies in sodium bis(2-ethylhexyl) sulfosuccinate (aerosol-OT, AOT)-based reverse micelles show that carboplatin associates and at least partially penetrates the surfactant interface. Langmuir monolayers formed by dipalmitoyl(phosphatidyl)choline are penetrated by carboplatin. Carboplatin was found to also penetrate the more rigid monolayers containing cholesterol. A combined mixed surfactant... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513283 Thu, 01 Dec 2011 05:00:00 +0100 5513283 http://www.medworm.com/index.php?rid=5513282&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162159%26dopt%3DAbstract The objective of this study was to compare six samples of Mexican wild common bean (Phaseolus vulgaris L.) against three landraces and three improved cultivars with respect to physical and chemical attributes, and the culinary quality potential of their grain. A completely randomized experimental design was used to characterize the twelve genotypes. Data were analyzed by analysis of variance and pair-wise comparison of the treatment means by the Tukey test. In addition, correlation and principal-component analysis (PCA) were carried out using twelve characteristics of raw and four of cooked wild and domesticated grains. The results show a larger variability of the physical and chemical characteristics in wild than in domesticated beans. The PCA confirmed that grain gigantism was the main p... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513282 Thu, 01 Dec 2011 05:00:00 +0100 5513282 http://www.medworm.com/index.php?rid=5513281&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162160%26dopt%3DAbstract Authors: Caruso I, Lepore L, De Tommasi N, Dal Piaz F, Frusciante L, Aversano R, Garramone R, Carputo D Abstract The main aim of this work was to study the leaf secondary metabolite profiles of artificially induced tetraploids (2n=4x=48) of Solanum commersonii, a diploid (2n=2x=24) wild potato species. The tetraploid genotypes of S. commersonii were produced by oryzalin treatment. Both HPLC-UV and LC/MS analyses revealed that there were no qualitative differences in the metabolite profiles between the diploid S. commersonii and its tetraploids. By contrast, the results showed that the phenylpropanoid content was generally significantly higher in the tetraploids than in the diploid S. commersonii. Concerning the glycoalkaloids (GAs), the results provided evidence that the content of... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513281 Thu, 01 Dec 2011 05:00:00 +0100 5513281 http://www.medworm.com/index.php?rid=5513280&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162161%26dopt%3DAbstract Authors: Sirirak T, Intaraksa N, Kaewsuwan S, Yuenyongsawad S, Suwanborirux K, Plubrukarn A Abstract Pachastrissa nux has two distinctive growth forms in one colony, i.e., the protruding gorgonian-shaped capitum and the substratum-attached irregular-shaped base. The sponge has the ability to allocate specifically its major secondary metabolites to the two parts in different levels. Using two cytotoxic trisoxazole macrolides, kabiramides C (2) and G (3), as chemical markers, it was found that the capitum accumulated higher contents of either or both compounds than did the base. However, there were neither inductive nor suppressive correlations among the allocation profiles of either compound in either part of the sponge. The allocation of kabiramides was a trade-off with the structu... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513280 Thu, 01 Dec 2011 05:00:00 +0100 5513280 http://www.medworm.com/index.php?rid=5513279&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162162%26dopt%3DAbstract Authors: Nikolić B, Ristić M, Tešević V, Marin PD, Bojović S Abstract Terpenes are often used as ecological and chemotaxonomic markers of plant species, as well as for estimation of geographic variability. Essential oils of relic and Balkan endemic/subendemic conifers, Picea omorika, Pinus heldreichii, and P. peuce, in central part of Balkan Peninsula (Serbia and Montenegro), on the level of terpene classes and common terpene compounds were investigated. In finding terpene combinations, which could show the best diversity between species and their natural populations, several statistical methods were applied. Apart from the content of different terpene classes (P. omorika has the most abundant O-containing monoterpenes and sesquiterpenes; P. heldreichii and P. peuce have the l... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513279 Thu, 01 Dec 2011 05:00:00 +0100 5513279 http://www.medworm.com/index.php?rid=5513278&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162163%26dopt%3DAbstract Authors: Luo J, Li Y, Wang JS, Kong LY Abstract Five new D-ring-opened phragmalin-type limonoids, tabulalins A-E (1-5, resp.), were isolated from the stem bark of Chukrasia tabularis var. velutina. In the structures of these new isolates, the D-ring (C(16)/C(17) δ-lactone ring) of phragmalins was cleaved, and rare C(16)/C(30) δ-lactone ring in 1-3 or C(16)/C(8) γ-lactone ring in 4 and 5 were formed. The structures of these new compounds were elucidated based on extensive 1D- and 2D-spectroscopic analyses (HSQC, HMBC, and ROESY) and HR-ESI-MS. The major compounds, 2, 3, and 5, were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in a macrophage (RAW264.7) cell line with IC(50) values of 15.3±0.6, 13.0±0.5, and 17.1... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513278 Thu, 01 Dec 2011 05:00:00 +0100 5513278 http://www.medworm.com/index.php?rid=5513277&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162164%26dopt%3DAbstract Authors: He JB, Yan YM, Ma XJ, Lu Q, Li XS, Su J, Li Y, Liu GM, Cheng YX Abstract Two coriamyrtin-type sesquiterpenes, fengfangin A (1) and tutin (2), and six diarylheptanoids, namely alnusone (3), centrolobol (4), muricarpone B (5), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-one (6), (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-ol (7), and (3S)-1-(4-hydroxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-ol (8), were isolated from the 95% EtOH extract of nidus vespae, the nest of Polistes species. Their structures were identified by spectroscopic methods. Compounds 1 and 8 are new products. The absolute configuration of 1 was determined by single-crystal X-ray diffraction analysis using Flack parameter. The biological tests showed that compounds 5, 6, and 8 could inhib... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513277 Thu, 01 Dec 2011 05:00:00 +0100 5513277 http://www.medworm.com/index.php?rid=5513276&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162165%26dopt%3DAbstract Authors: Wang K, Sasaki T, Li W, Li Q, Wang Y, Asada Y, Kato H, Koike K Abstract Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC(50) values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase. PMID: 22162165 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513276 Thu, 01 Dec 2011 05:00:00 +0100 5513276 http://www.medworm.com/index.php?rid=5513275&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162166%26dopt%3DAbstract Authors: Liang WL, Hsiao CJ, Ju YM, Lee LH, Lee TH Abstract One new betaenone, theissenoic acid (1), together with three new acetogenins, theissenolactones A-C (2-4, resp.), were isolated from the fermented broth of Theissenia cinerea 89091602 isolated in Taiwan. The structures of 1-4 were elucidated by spectroscopic methods. Biological tests revealed that 3 and 4 exhibited moderate growth-inhibitory activities against A549 lung cancer cell line with GI(50) values of 14.9 and 47.9 μM, respectively. PMID: 22162166 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513275 Thu, 01 Dec 2011 05:00:00 +0100 5513275 http://www.medworm.com/index.php?rid=5513274&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162167%26dopt%3DAbstract Authors: Kennedy ML, Llanos GG, Castanys S, Gamarro F, Bazzocchi IL, Jiménez IA Abstract The phytochemical analysis of the root bark extracts of the Chilean Maytenus, M. chubutensis, and M. magellanica (Celastraceae), led to the isolation of one phenolic nortriterpene, 1, and one diterpene with a nor-ent-kaurene skeleton, 2. In addition, four known compounds were isolated, among which compound 3 has been isolated for the first time from a natural source. Their structures were elucidated by spectroscopic methods, including 1D- and 2D-NMR (COSY, ROESY, HSQC, and HMBC) experiments, comparison with data reported in the literature, and chemical correlations. The isolated compounds were assayed for their reversal activity against a multidrug-resistant Leishmania tropica line, overexpres... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513274 Thu, 01 Dec 2011 05:00:00 +0100 5513274 http://www.medworm.com/index.php?rid=5513273&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162168%26dopt%3DAbstract Authors: Li YL, Wu L, Ouyang DW, Yu P, Xia JH, Pan YX, Yang XW, Zeng HW, Cheng XR, Jin HZ, Zhang WD Abstract Two new, i.e., 1 and 2, and 69 known phenolics were isolated from the aerial parts of Abies nephrolepis. These chemical constituents included 22 lignans, 30 flavonoids, and 19 other phenols. Their structures were determined mainly by analysis of the 1D- and 2D-NMR spectroscopic data. All the 71 isolates were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages. Compound 1 exhibited a potent effect with an IC(50) value of 13.7 μg/ml. PMID: 22162168 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513273 Thu, 01 Dec 2011 05:00:00 +0100 5513273 http://www.medworm.com/index.php?rid=5513272&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162169%26dopt%3DAbstract Authors: Blažević I, Radonić A, Skočibušić M, De Nicola GR, Montaut S, Iori R, Rollin P, Mastelić J, Zekić M, Maravić A Abstract Glucosinolates (GLs) were characterized in various aerial parts (stems, leaves, and flowers) of Aurinia leucadea (Guss.) C. Koch and quantified according to the ISO 9167-1 official method based on the HPLC analysis of desulfoglucosinolates. Eight GLs, i.e., glucoraphanin (GRA), glucoalyssin (GAL; 1), gluconapin (GNA; 2), glucocochlearin (GCC), glucobrassicanapin (GBN; 3), glucotropaeolin (GTL), glucoerucin (GER), and glucoberteroin (GBE) were identified. The total GL contents were 57.1, 37.8, and 81.3 μmol/g dry weight in the stems, leaves, and flowers, respectively. The major GL detected in all parts of the plant was 2, followed by 1 and 3. G... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513272 Thu, 01 Dec 2011 05:00:00 +0100 5513272 http://www.medworm.com/index.php?rid=5513271&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162170%26dopt%3DAbstract Authors: Shen Y, Lebold K, Lansky EP, Traber MG, Nevo E Abstract Hordeum spontaneum, wild barley, is the direct progenitor of domestic barley, Hordeum vulgare, an economically important ingredient of animal feed, beer, soy sauce, and more recently, of nutraceuticals. Domestic barley has also been used in the past as a medicine. Barley is a rich source of tocotrienols, with α-tocotrienol being the most prevalent. Wild barley seeds were harvested from ecogeographically diverse areas across the Fertile Crescent, and the tocopherol (α-δ) and tocotrienol (α-δ) contents were determined. Diversity differences in individual and total 'tocol' values were significant between and within specific countries, and were significantly correlated with temperature. Wild barley may be used in the... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513271 Thu, 01 Dec 2011 05:00:00 +0100 5513271 http://www.medworm.com/index.php?rid=5513270&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162171%26dopt%3DAbstract Authors: Wang X, Habib E, León F, Radwan MM, Tabanca N, Gao J, Wedge DE, Cutler SJ Abstract A preparative overpressure layer chromatography (OPLC) method was successfully used for the separation of two new natural compounds, 4-hydroxy-5,6-dimethoxynaphthalene-2-carbaldehyde (1) and 12,13-didehydro-20,29-dihydrobetulin (2) together with nine known compounds, including 7-methyljuglone (3), diospyrin (4), isodiospyrin (5), shinanolone (6), lupeol (7), betulin (8), betulinic acid (9), betulinaldehyde (10), and ursolic acid (11) from the acetone extract of the roots of Diospyros virginiana. Their identification was accomplished by 1D- and 2D-NMR spectroscopy and HR-ESI-MS methods. All the isolated compounds were evaluated for their antifungal activities against Colletotrichum fragariae... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513270 Thu, 01 Dec 2011 05:00:00 +0100 5513270 http://www.medworm.com/index.php?rid=5513269&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162172%26dopt%3DAbstract Authors: PMID: 22162172 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5513269 Thu, 01 Dec 2011 05:00:00 +0100 5513269 http://www.medworm.com/index.php?rid=5419772&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083907%26dopt%3DAbstract Authors: Zhao P, Gao DF, Xu M, Shi ZG, Wang D, Yang CR, Zhang YJ PMID: 22083907 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419772 Tue, 01 Nov 2011 04:00:00 +0100 5419772 http://www.medworm.com/index.php?rid=5419771&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083908%26dopt%3DAbstract Authors: Zhao J, Ding HX, Song QY, Gao K PMID: 22083908 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419771 Tue, 01 Nov 2011 04:00:00 +0100 5419771 http://www.medworm.com/index.php?rid=5419770&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083909%26dopt%3DAbstract Authors: Chen YG, Wu JC, Chen GY, Han CR, Song XP PMID: 22083909 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419770 Tue, 01 Nov 2011 04:00:00 +0100 5419770 http://www.medworm.com/index.php?rid=5419769&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083910%26dopt%3DAbstract Authors: Kong DX, Guo MY, Xiao ZH, Chen LL, Zhang HY Abstract To evaluate the potential of natural products as novel structure suppliers, a historical analysis was performed on the structural novelty of a natural product library, viz., the Chapman & Hall/CRC Dictionary of Natural Products. The results show that although the unexplored natural product universe is still ample, it is more and more difficult to find novel agents from nature, with the discovery probability of novel structures and scaffolds being lower than 50% in the near future, which mainly results from the intrinsic redundancy of natural products and, thus, is unlikely to be reversed merely through technical progresses. PMID: 22083910 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419769 Tue, 01 Nov 2011 04:00:00 +0100 5419769 http://www.medworm.com/index.php?rid=5419768&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083911%26dopt%3DAbstract Authors: Liber Z, Carović-Stanko K, Politeo O, Strikić F, Kolak I, Milos M, Satovic Z Abstract Twenty-seven Ocimum basilicum cultivars were subjected to a chemical characterization of essential oil components by gas chromatography/mass spectrometry (GC/MS) and a genetic characterization using the amplified fragment-length polymorphism (AFLP) technique. Since the same 27 accessions had previously been classified into six morphotypes, these analyses allowed us to make detailed comparisons of chemistry, genetics, and morphology. The chemical composition and morphology of the studied cultivars appeared to have a strong genetic component. The AFLP analysis revealed a distinction between the green and purple morphotypes. The green morphotypes predominantly utilized the terpene biosynth... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419768 Tue, 01 Nov 2011 04:00:00 +0100 5419768 http://www.medworm.com/index.php?rid=5419767&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083912%26dopt%3DAbstract Authors: Sellami HK, Flamini G, Cioni PL, Smiti S Abstract The composition of the essential oils isolated by hydrodistillation from various organs at different development stages of Ammi visnaga (L.) Lam. growing in Tunisia was determined by GC/MS analysis. In particular, the oil profiles of the leaves, stems, flower buds, roots, umbels, and fruits have been examined during the whole life cycle. The oil from the flowering aerial parts was characterized by a high content of isoamyl 2-methylbutanoate. After flowering and during desiccation and fructification, the umbels and fruits expressed a high content of linalool. The oils, extracted from the roots collected in the vegetatif, buds floral, and floral stages, were rich in monoterpene aldehydes, oxygenated monoterpenes, and monoterp... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419767 Tue, 01 Nov 2011 04:00:00 +0100 5419767 http://www.medworm.com/index.php?rid=5419766&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083913%26dopt%3DAbstract Authors: Wahab IR, Blagojević PD, Radulović NS, Boylan F Abstract Analysis by GC and GC/MS of the essential oil obtained from Malaysian Curcuma mangga Val. & Zijp (Zingiberaceae) rhizomes allowed the identification of 97 constituents, comprising 89.5% of the total oil composition. The major compounds were identified as myrcene (1; 46.5%) and β-pinene (2; 14.6%). The chemical composition of this and additional 13 oils obtained from selected Curcuma L. taxa were compared using multivariate statistical analyses (agglomerative hierarchical cluster analysis and principal component analysis). The results of the statistical analyses of this particular data set pointed out that 1 could be potentially used as a valuable infrageneric chemotaxonomical marker for C. mangga. Moreover, it... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419766 Tue, 01 Nov 2011 04:00:00 +0100 5419766 http://www.medworm.com/index.php?rid=5419765&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083914%26dopt%3DAbstract Authors: Chou TH, Chen JJ, Peng CF, Cheng MJ, Chen IS Abstract Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H(37) Rv strain in vitro with MIC values of 3.5 and 25.0 μg/ml, respectively. PMID: 22083914 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419765 Tue, 01 Nov 2011 04:00:00 +0100 5419765 http://www.medworm.com/index.php?rid=5419764&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083915%26dopt%3DAbstract Authors: Wang JS, Zhang Y, Wei DD, Wang XB, Luo J, Kong LY Abstract Phytochemical investigation on the stem bark of Aphanamixis grandifolia afforded five novel tirucallane-type triterpenoids, (13α,14β,17α,23Z)-25-methoxy-21,23-epoxylanosta-7,20(22),23-triene-3,21-dione (1), (13α,14β,17α,23Z)-21,23-epoxylanosta-7,20(22),23,25-tetraene-3,21-dione (2), (3R,5R, 9R,10R,13S,14S,17S)-17-{(2R,3S,5R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-2,3,4,5-tetrahydro-2,5-dimethoxyfuran-3-yl}-4,4,10,13,14-pentamethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (3), (5R,9R,10R,13S,14S,17S)-17-{(2R,3S,5R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-2,5-dimethoxytetrahydrofuran-3-yl}-1,2,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-4,4,10,13,14-pentamethyl-3H-cyclopenta[a]p... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419764 Tue, 01 Nov 2011 04:00:00 +0100 5419764 http://www.medworm.com/index.php?rid=5419763&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083916%26dopt%3DAbstract We report here a novel expansion of these studies by introducing gluco- or galactopyranosyl scaffold to the N- or 9-position (or both) of 6-Cl purine moiety via Cu(I) -catalyzed Huisgen 1,3-dipolar cycloaddition. By such an efficient reaction, a series of glycosyl-triazolyl-purines were successfully synthesized in good yields. Biological evaluation showed that the majority of these glycoconjugates were good PTP1B inhibitors with IC(50) values in low micromolar range (1.5-11.1 μM). The benzylated sugar derivatives displayed better inhibitory potency than that of the acetylated ones. Replacement of Cl by MeO at C(6) of the purine moiety decreased the inhibition in the case of benzylated (glycosyl-mono-triazolyl)-purines 11 and 12 (IC(50) >80 μM), whereas MeO-substituted benzylated b... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419763 Tue, 01 Nov 2011 04:00:00 +0100 5419763 http://www.medworm.com/index.php?rid=5419762&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083917%26dopt%3DAbstract Authors: Dawidowicz AL, Czapczyńska NB Abstract Essential oils are one of nature's most precious gifts with surprisingly potent and outstanding properties. Coniferous oils, for instance, are nowadays being used extensively to treat or prevent many types of infections, modify immune responses, soothe inflammations, stabilize moods, and to help ease all forms of non-acute pain. Given the broad spectrum of usage of coniferous essential oils, a fast, safe, simple, and efficient sample-preparation method is needed in the estimation procedure of essential oil components in fresh plant material. Generally, the time- and energy-consuming steam distillation (SD) is applied for this purpose. This paper will compare SD, pressurized liquid extraction (PLE), matrix solid-phase dispersion (MSPD... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419762 Tue, 01 Nov 2011 04:00:00 +0100 5419762 http://www.medworm.com/index.php?rid=5419761&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083918%26dopt%3DAbstract Authors: Maggi F, Mártonfi P, Conti F, Cristalli G, Papa F, Sagratini G, Vittori S Abstract The aim of this work was to trap the volatiles released from whole frozen and dry aerial parts, and, separately, from different organs (leaves, stems, corolla and calyx) of bastard balm (Melittis melissophyllum L., Lamiaceae) populations collected in Italy and Slovakia by HS-SPME, and to identify the headspace constituents responsible for the characteristic aroma impression by GC/FID and GC/MS techniques. Among more than 100 volatile components detected, the C(8) alcohol oct-1-en-3-ol, responsible for the typical mushroom-like odor, and the phenolic coumarin, with a characteristic sweet and creamy vanilla bean odor, played a major role in the aroma of whole aerial parts and different plant ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419761 Tue, 01 Nov 2011 04:00:00 +0100 5419761 http://www.medworm.com/index.php?rid=5419760&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083919%26dopt%3DAbstract Authors: Triana J, López M, Pérez FJ, León F, Quintana J, Estévez F, Hernández JC, González-Platas J, Brouard I, Bermejo J Abstract Two new compounds, the sesquiterpene (1E,5E)-8β-acetoxy-4α-hydroxy-7βH-germacra-1(10),5-dien-14-oic acid (2), and a nor-sesquiterpene, (5E)-8β-acetoxy-4α-hydroxy-7βH-germacr-5-en-10-one (3), were isolated from Pulicaria canariensis ssp. lanata, along with ten known compounds, including the flavonoid 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (4). From Pulicaria burchardii, we isolated seven known compounds; the physical and spectroscopic data of the triterpenoid 3β-hydroxytaraxaster-20-en-30-al (1) are reported. The structures of compounds 1-3 were determined on the basis of HR-MS, and 1D- and 2D-NMR studies. The structure of 2 was corroborat... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419760 Tue, 01 Nov 2011 04:00:00 +0100 5419760 http://www.medworm.com/index.php?rid=5419759&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083920%26dopt%3DAbstract Authors: De Nicola GR, Blažević I, Montaut S, Rollin P, Mastelić J, Iori R, Tatibouët A Abstract The glucosinolates present in the leaf, stem, and seed extracts of Degenia velebitica (Degen) Hayek were characterized and quantified according to the ISO 9167-1 method, which is based on the HPLC analysis of desulfoglucosinolates. The stems contained glucoalyssin (3a) as the major compound as well as glucoberteroin (1a) and glucoaubrietin (4a). The leaves contained three glucosinolates, the major one being 3a, followed by glucobrassicanapin (2a) and 1a. Glucoberteroin (1a) was the major glucosinolate in the seeds, along with the two minor glucosinolates 3a and glucoerucin (5a). The content of 1a in the whole, non-defatted seeds amounted to 4% (w/w). The compound was characterized a... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419759 Tue, 01 Nov 2011 04:00:00 +0100 5419759 http://www.medworm.com/index.php?rid=5419758&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083921%26dopt%3DAbstract Authors: Mojarrab M, Delazar A, Moghadam SB, Nazemiyeh H, Nahar L, Kumarasamy Y, Asnaashari S, Hadjiakhoondi A, Sarker SD Abstract The reversed-phase (RP) preparative HPLC analyses of the MeOH extract of the aerial parts of Artemisia armeniaca yielded four prenylated coumarins, 7-hydroxy-8-(4-hydroxy-3-methylbutoxy)coumarin (named armenin), 8-hydroxy-7-(4-hydroxy-3-methylbutoxy)coumarin (named isoarmenin), lacarol, and deoxylacarol, together with five other compounds, including three flavonoid glycosides, quercetin 3-O-β-D-glucopyranoside, rutin, and kaempferol 3-O-β-D-glucopyranoside, and chlorogenic acid, and tryptophan. (10E,12Z)-9-Hydroxyoctadeca-10,12-dienoic acid (β-dimorphecolic acid) was isolated from the CH(2) Cl(2) extract. Armenin and isoarmenin were new coumarins. St... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419758 Tue, 01 Nov 2011 04:00:00 +0100 5419758 http://www.medworm.com/index.php?rid=5419757&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083922%26dopt%3DAbstract Authors: He YQ, Ma ZY, Wei XM, Liu DJ, Du BZ, Yao BH, Gao LM Abstract A novel diterpene alkaloid named honatisine (1) has been isolated from the whole plants of Delphinium honanense, along with six known alkaloids, siwanine E (2), isoatisine (3), atisine (4), delcorinine (5), uraphine (6), and nordhagenine A (7). Their structures were deduced on the basis of their spectral data. All of them were evaluated by a SRB assay for their cytotoxicity, and compound 1 showed a significant cytotoxic activity (IC(50) =3.16 μM) against the MCF-7 cell line. PMID: 22083922 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419757 Tue, 01 Nov 2011 04:00:00 +0100 5419757 http://www.medworm.com/index.php?rid=5419756&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083923%26dopt%3DAbstract Authors: Liu H, Tsim KW, Chou GX, Wang JM, Ji LL, Wang ZT Abstract One new bibenzyl, 7, and one new diarylheptanone, diobulbinone A (18), together with sixteen known compounds, 1-6 and 8-17, have been isolated form the rhizomes of Dioscorea bulbifera. Their structures were elucidated by NMR and MS analyses. Compound 7 showed high antioxidant capacity in FRAP assay and DPPH radical-scavenging activity. PMID: 22083923 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419756 Tue, 01 Nov 2011 04:00:00 +0100 5419756 http://www.medworm.com/index.php?rid=5419755&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083924%26dopt%3DAbstract Authors: Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS Abstract Four new doramectin congeners, 1-4, were isolated from Streptomyces avermitilis NEAU1069. The structures of 1-4 were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS, ESI-MS, UV, and IR, and comparison with literature data. All compounds exhibited noticeable acaricidal and insecticidal activities. Especially compound 2 was found to be the most potent pesticide of the compounds evaluated with the IC(50) values of 10.2, 65.1 and 124.4 μg/ml against adult two-spotted spider mites (Tetranychus urticae Koch), two-spotted spider mite eggs, and Mythimna separata, respectively, which are comparable to those of commercial pesticide milbemycin A(3) /A(4) as posi... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419755 Tue, 01 Nov 2011 04:00:00 +0100 5419755 http://www.medworm.com/index.php?rid=5419754&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083925%26dopt%3DAbstract Authors: Bruzual De Abreu M, Temraz A, Malafronte N, Gonzalez-Mujica F, Duque S, Braca A Abstract Two new compounds, 5-methyl-2-(2-methylbutanoyl)phloroglucinol 1-O-(6-O-β-D-apiofuranosyl)-β-D-glucopyranoside (1) and trans-2,3-dihydrokaempferol 3-O-(4-O-sulfo)-α-L-arabinopyranoside (2), together with 14 known flavonoids, trans-dihydrokaempferol 3-O-α-L-arabinopyranoside (3), trans-taxifolin 3-O-α-L-arabinofuranoside (4), quercetin 3-O-α-L-rhamnopyranoside (5), quercetin 3'-O-α-L-arabinofuranoside (6), catechin 3-O-α-L-rhamnopyranoside (7), trans-taxifolin 3-O-α-L-arabinopyranoside (8), cis-dihydrokaempferol 3-O-α-L-arabinopyranoside (9), catechin (10), myricetin 3-O-α-L-rhamnopyranoside (11), quercetin 3-O-α-L-arabinopyranoside (12), quercetin 3-O-α-L-arabinofuranosi... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419754 Tue, 01 Nov 2011 04:00:00 +0100 5419754 http://www.medworm.com/index.php?rid=5419753&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083926%26dopt%3DAbstract Authors: Cai TG, Cai Y Abstract Two new triterpenes, 29-hydroxydehydrotumulosic acid (1) and 29-hydroxydehydropachymic acid (2), together with six known compounds, dehydropachymic acid (3), dehydrotumulosic acid (4), 29-hydroxypolyporenic acid C (5), polyporenic acid C (6), tumulosic acid (7), and pachymic acid (8), were isolated from the dried sclerotia of Poria cocos. In the in vitro bioassays, these isolated compounds reduced, in a dose-dependent manner, nitric oxide (NO) production from lipopolysaccharide (LPS)-induced RAW 264.7 cells, with compounds 5 and 6, the IC(50) values of which were 16.8±2.7 and 18.2±3.3 μM, respectively, exhibiting the greatest inhibition activity. Further Western blot analysis conducted on cells pre-treated with compounds 5 and 6, and luciferase ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419753 Tue, 01 Nov 2011 04:00:00 +0100 5419753 http://www.medworm.com/index.php?rid=5419752&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083927%26dopt%3DAbstract Authors: Işcan G, Köse YB, Demirci B, Can Başer KH Abstract Hydrodistallation of the aerial parts of Nepeta transcaucasica Grossh. (Lamiaceae), collected in Ağrı, Doğubayazıt Province, afforded an essential oil that was characterized by GC and GC/MS analyses. Twenty-seven compounds, representing 97.69% of the total oil composition, were identified, and 4aα,7α,7aβ-nepetalactone (1; 39%), 4aα,7α,7aα-nepetalactone (2; 28%), and germacrene D (3; 15%) constituted the major components. The anticandidal effects of the oil were evaluated against seven Candida strains by using the broth microdilution method. The oil showed good inhibitory effects against C. glabrata and C. tropicalis at minimal inhibitory concentrations (MICs) of 0.09 and 0.375 mg/ml, respectively. PMID: ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419752 Tue, 01 Nov 2011 04:00:00 +0100 5419752 http://www.medworm.com/index.php?rid=5419751&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083928%26dopt%3DAbstract Authors: Caixeta SC, Magalhães LG, de Melo NI, Wakabayashi KA, de P Aguiar G, de P Aguiar D, Mantovani AL, Alves JM, Oliveira PF, Tavares DC, Groppo M, Rodrigues V, Cunha WR, Veneziani RC, da Silva Filho AA, Crotti AE Abstract The chemical composition and the in vitro schistosomicidal effects of the essential oil of Plectranthus neochilus (PN-EO) grown in Southeast Brazil was studied. β-Caryophyllene (1; 28.23%), α-thujene (2; 12.22%), α-pinene (3; 12.63%), β-pinene (4; 6.19%), germacrene D (5; 5.36%), and caryophyllene oxide (6; 5.37%) were the major essential oil constituents. This chemical composition differed from that previously reported for specimens harvested in Africa. Concerning the in vitro schistosomicidal activity against adult Schistosoma mansoni worms, PN-EO was ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419751 Tue, 01 Nov 2011 04:00:00 +0100 5419751 http://www.medworm.com/index.php?rid=5419750&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083929%26dopt%3DAbstract Authors: Greer A PMID: 22083929 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5419750 Tue, 01 Nov 2011 04:00:00 +0100 5419750 http://www.medworm.com/index.php?rid=5344796&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006710%26dopt%3DAbstract Authors: Formisano C, Rigano D, Senatore F PMID: 22006710 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344796 Sat, 01 Oct 2011 04:00:00 +0100 5344796 http://www.medworm.com/index.php?rid=5344795&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006711%26dopt%3DAbstract Authors: Síma J, Holcová V Abstract Removal of nonionic surfactants from municipal wastewater using a constructed wetland with a horizontal subsurface flow was studied in 2009 and 2010. Extraction spectrophotometry with 3',3″,5',5″-tetrabromophenolphthalein ethyl ester and KCl served to determine the analyte concentrations. Triton(®) X-100 was used as a standard to express the nonionic-surfactant concentrations. Anionic and cationic surfactants were shown not to interfere during the determination. Nonionic surfactants were degraded (to products undeterminable by the method) with a high average efficiency that reached 98.1% in 2009 and 99.1% in 2010, respectively. The average concentration of nonionic surfactants at the inflow was 0.978 mg/l, while it was close to the limit... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344795 Sat, 01 Oct 2011 04:00:00 +0100 5344795 http://www.medworm.com/index.php?rid=5344794&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006712%26dopt%3DAbstract Authors: Gong W, Jiang Z, Sun P, Li L, Jin Y, Shao L, Zhang W, Liu B, Zhang H, Tang H, Chen Y, Yi Y, Zhang D Abstract A series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)-induced NO production, haemolytic activity, and cell viability was evaluated. Structureactivity relationship was established by comparing the derivatives of esculentoside A with its aglycone derivatives. Both the aglycone and its derivatives showed higher inhibitory effects on LPS-induced NO production, and lower haemolytic activities than esculentoside A and its derivatives. PMID: 22006712 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344794 Sat, 01 Oct 2011 04:00:00 +0100 5344794 http://www.medworm.com/index.php?rid=5344793&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006713%26dopt%3DAbstract Authors: Zhu GY, Li YW, Kwok-Po Hau D, Jiang ZH, Yu ZL, Fong WF Abstract Six new protopanaxadiol-type ginsenosides, named ginsenosides Ra(4) -Ra(9) (1-6, resp.), along with 14 known dammarane-type triterpene saponins, were isolated from the root of Panax ginseng, one of the most important Chinese medicinal herbs. The structures of the new compounds were determined by spectroscopic methods, including 1D- and 2D-NMR, HR-MS, and chemical transformation as (20S)- 3-O-{β-D-6-O-[(E)-but-2-enoyl]glucopyranosyl-(1→2)-β-D-glucopyranosyl}-20-O-[β-D-xylopyranosyl-(1→4)-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranosyl]protopanaxadiol (1), (20S)-3-O-[β-D-6-O-acetylglucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-[β-D-xylopyranosyl-(1→4)-α-L-arabinopyranosyl-(1→6)-β-D-glucopyrano... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344793 Sat, 01 Oct 2011 04:00:00 +0100 5344793 http://www.medworm.com/index.php?rid=5344792&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006714%26dopt%3DAbstract Authors: Shi XW, Li XJ, Gao JM, Zhang XC Abstract Two new highly oxygenated fasciculol-type lanostane derivatives, fasciculols H and I (1 and 2, resp.), together with five known compounds, 3-7, were isolated from the fruiting bodies of the Chinese toxic mushroom Naematoloma fasciculare. Their structures were elucidated on the basis of spectroscopic analyses including 2D-NMR (HMBC, HSQC, NOESY, (1) H,(1) H-COSY). Compounds 5-7 were identified for the first time in this mushroom. Compounds 1, 3, 4, and 5 were evaluated for inhibitory activity against human glioma cell line U87 and nuclear factor-κB. PMID: 22006714 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344792 Sat, 01 Oct 2011 04:00:00 +0100 5344792 http://www.medworm.com/index.php?rid=5344791&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006715%26dopt%3DAbstract We present here the syntheses of a mononuclear Cu(II) complex and two polynuclear Cu(II) Ni(II) complexes of the azenyl ligand, 4-(pyridin-2-ylazenyl)resorcinol (HL; 1). The reaction of HL (1) and copper(II) perchlorate with KCN gave a mononuclear complex [CuL(CN)] (4). Using 4, one pentanuclear complex, [{CuL(NC)}(4) Ni](ClO(4) )(2) (5) and one trinuclear complex, [{CuL(CN)}(2) NiL]ClO(4) (6), were prepared and characterized by elemental analyses, magnetic susceptibility, molar conductance, IR, and thermal analysis. Stoichiometric and spectral results of the mononuclear Cu(II) complex indicated that the metal/ligand/CN ratio was 1 : 1 : 1, and the ligand behaved as a tridentate ligand forming neutral metal chelates through the pyridinyl and azenyl N-, and resorcinol O-atom. The... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344791 Sat, 01 Oct 2011 04:00:00 +0100 5344791 http://www.medworm.com/index.php?rid=5344790&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006716%26dopt%3DAbstract Authors: Argyropoulou C, Karioti A, Skaltsa H Abstract Five new labdane diterpenes, thessalines A, B, and D, 14β-hydroxythessaline A, and 14β-hydroxythessaline B (1-5, resp.) were isolated from the aerial parts of Marrubium thessalum, along with the known labdane diterpene deacetylvitexilactone (6) and the methoxylated flavones 4',7-dimethylapigenin and salvigenin. (3S,5R)-Loliolide was also found in the same source. Their structures were established by 1D- and 2D-NMR (COSY, HSQC, HMBC, NOESY, and ROESY) and MS analyses. The plant produces a great variety of labdane-type diterpenes, with variations in functionalities, particularly in the side chain. Their structures could be of chemotaxonomic significance for the genus Marrubium. PMID: 22006716 [PubMed - in process] (Source: ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344790 Sat, 01 Oct 2011 04:00:00 +0100 5344790 http://www.medworm.com/index.php?rid=5344789&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006717%26dopt%3DAbstract Authors: Xu M, Zhang M, Wang D, Yang CR, Zhang YJ Abstract Gentiana rhodantha Franch. ex Hemsl. (Gentianaceae), an annual herb widely distributed in the southwest of China, has been medicinally used for the treatment of inflammation, cholecystitis, and tuberculosis by the local people of its growing areas. Chemical investigation on the whole plants led to the identification of eight new phenolic compounds, rhodanthenones A-D (1-4, resp.), apigenin 7-O-glucopyranosyl-(1→3)-glucopyranosyl-(1→3)-glucopyranoside (5), 1,2-dihydroxy-4-methoxybenzene 1-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (6), 1,2-dihydroxy-4,6-dimethoxybenzene 1-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (7), and methyl 2-O-β-D-glucopyranosyl-2,4,6-trihydroxybenzoate (8), together with eleven... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344789 Sat, 01 Oct 2011 04:00:00 +0100 5344789 http://www.medworm.com/index.php?rid=5344788&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006718%26dopt%3DAbstract Authors: Hsieh CL, Tseng MH, Pan RN, Chang JY, Kuo CC, Lee TH, Kuo YH Abstract Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C(20) C(10) skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC(50) value of 9.0±0.1 μM. PMID: 22006718 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344788 Sat, 01 Oct 2011 04:00:00 +0100 5344788 http://www.medworm.com/index.php?rid=5344787&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006719%26dopt%3DAbstract Authors: Wang PC, Ran XH, Chen R, Luo HR, Ma QY, Liu YQ, Hu JM, Huang SZ, Jiang HZ, Chen ZQ, Zhou J, Zhao YX Abstract Two new guaiane-type sesquiterpenoids, valerol A (1) and kessyl 3-acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4α,10α-epoxyaromadendrane (7), (+)-8-hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4-O-β-D-glucopyranoside (10), and 8-hydroxypinoresinol 4'-O-β-D-glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D- and 2D-NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerv... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344787 Sat, 01 Oct 2011 04:00:00 +0100 5344787 http://www.medworm.com/index.php?rid=5344786&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006720%26dopt%3DAbstract Authors: Zou X, Liu S, Zheng Z, Zhang H, Chen X, Liu X, Li E Abstract Tricladins A and B (1 and 2, resp.), new imidazolone-containing alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b) -acetyltryptamine (7), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA-MB-231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV-1 replication in C8166 cells. PMID: 22006720 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344786 Sat, 01 Oct 2011 04:00:00 +0100 5344786 http://www.medworm.com/index.php?rid=5344785&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006721%26dopt%3DAbstract Authors: Verma RS, Verma RK, Padalia RC, Chauhan A, Singh A, Singh HP Abstract To explore the diversity in the essential oil yield and composition of Valeriana jatamansi Jones (syn. V. wallichii DC) growing wild in Uttarakhand (Western Himalaya), 17 populations were collected from different locations and grown under similar conditions. Comparative results showed considerable variations in the essential oil yield and composition. The essential oil yield varied from 0.21 to 0.46% in the fresh roots and rhizomes of different populations of V. jatamansi. Analysis of the essential oils by GC (RI) and GC/MS and the subsequent classification by principal component analysis (PCA) resulted in six clusters with significant variations in their terpenoid composition. Major components in the es... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5344785 Sat, 01 Oct 2011 04:00:00 +0100 5344785 http://www.medworm.com/index.php?rid=5229968&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922653%26dopt%3DAbstract Authors: Stone MP, Huang H, Brown KL, Shanmugam G Abstract The formation of adducts by the reaction of chemicals with DNA is a critical step for the initiation of carcinogenesis. The structural analysis of various DNA adducts reveals that conformational and chemical rearrangements and interconversions are a common theme. Conformational changes are modulated both by the nature of adduct and the base sequences neighboring the lesion sites. Equilibria between conformational states may modulate both DNA repair and error-prone replication past these adducts. Likewise, chemical rearrangements of initially formed DNA adducts are also modulated both by the nature of adducts and the base sequences neighboring the lesion sites. In this review, we focus on DNA damage caused by a number of env... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229968 Thu, 01 Sep 2011 04:00:00 +0100 5229968 http://www.medworm.com/index.php?rid=5229967&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922654%26dopt%3DAbstract Authors: Prakash TP Abstract Among the multitude of chemical modifications that have been described over the past two decades, oligonucleotide analogs that are modified at the 2'-position of the furanose sugar have been especially useful for improving the drug-like properties of antisense oligonucleotides (ASOs). These modifications bias the sugar pucker towards the 3'-endo-conformation and improve ASO affinity for its biological target (i.e., mRNA). In addition, antisense drugs incorporating 2'-modified nucleotides exhibit enhanced metabolic stability, and improved pharmacokinetic and toxicological properties. Further conformational restriction of the 2'-substituent to the 4'-position of the furanose ring yielded the 2',4'-bridged nucleic acid (BNA) analogs. ASOs containing BNA mo... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229967 Thu, 01 Sep 2011 04:00:00 +0100 5229967 http://www.medworm.com/index.php?rid=5229966&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922655%26dopt%3DAbstract Authors: Guga P, Koziołkiewicz M PMID: 21922655 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229966 Thu, 01 Sep 2011 04:00:00 +0100 5229966 http://www.medworm.com/index.php?rid=5229965&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922656%26dopt%3DAbstract Authors: Han N, Huang T, Wang YC, Yin J, Kadota S Abstract Two novel flavanone glycosides, homoeriodictyol 7-O-β-D-[6-(3-hydroxybutanoyl)glucopyranoside] (viscumneoside IX; 1) and homoeriodictyol 7-O-β-D-[6-(3-hydroxybutanoyl)glucopyranosyl](1→2)-β-D-glucopyranoside (viscumneoside X; 2), together with four known flavanoids, 2-homoeriodictyol 7-O-β-D-glucopyranoside (3), viscumneoside I (4), viscumneoside III (5), and 4',5-dihydroxy-3'-methoxy-7-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavanone (6) were isolated from stems and leaves of Viscum coloratum. Their structures were elucidated on the basis of their NMR spectra, HR-FAB-MS data, and acid hydrolysis. Inhibitory effects of the four compounds 1-4 on the formation of osteoclast-like multinucleated cells were inves... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229965 Thu, 01 Sep 2011 04:00:00 +0100 5229965 http://www.medworm.com/index.php?rid=5229964&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922657%26dopt%3DAbstract Authors: Yan S, Li S, Wu W, Zhao F, Bao L, Ding R, Gao H, Wen HA, Song F, Liu HW Abstract Three new sesquiterpene acids, xylaric acids A-C (1-3, resp.), and a new tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivative, 4, along with nine known compounds, xylaric acid D (5), hydroheptelidic acid (6), gliocladic acid (7), chlorine heptelidic acid (8), trichoderonic acid A (9), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (10), 16-(α-D-glucopyranosyloxy)isopimar-7-en-19-oic acid (11), 5-carboxymellein (12), and naphthalen-1,8-diol 1-O-α-D-glucopyranoside (13) have been isolated from the solid culture of the ascomycete fungus Xylaria sp. associated with termite nest. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configurations o... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229964 Thu, 01 Sep 2011 04:00:00 +0100 5229964 http://www.medworm.com/index.php?rid=5229963&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922658%26dopt%3DAbstract Authors: Lin HY, Chiu HL, Lan YH, Tzeng CY, Lee TH, Lee CK, Shao YY, Chen CR, Chang CI, Kuo YH Abstract Four new lactone chlorins, ficuschlorins A - D (1-4, resp.), and six known pheophytins were isolated from the leaves of Ficus microcarpa. The structures of these compounds were determined by 1D- and 2D-NMR spectroscopy, and other techniques. New natural pheophytins were rarely obtained. In the past ten years, only three new pheophytins were isolated from natural sources. PMID: 21922658 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229963 Thu, 01 Sep 2011 04:00:00 +0100 5229963 http://www.medworm.com/index.php?rid=5229962&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922659%26dopt%3DAbstract Authors: Cho JY, Lee TH, Hwang TL, Yang SZ, Chen IS, Chou TH, Sung PJ, Chen JJ Abstract A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4 : 3',4'-bis(O,O-methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC(50) values ≤21.8 μM) of O(2) (⋅-) generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-f... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229962 Thu, 01 Sep 2011 04:00:00 +0100 5229962 http://www.medworm.com/index.php?rid=5229961&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922660%26dopt%3DAbstract Authors: Wu SH, Zhao LX, Chen YW, Huang R, Miao CP, Wang J Abstract A new bisabolane-type sesquiterpene, trichoderic acid (1), and a new acorane-type sesquiterpene, 2β-hydroxytrichoacorenol (2), along with three known compounds, cyclonerodiol (3), cyclonerodiol oxide (4), and sorbicillin (5), were isolated from the culture broth of Trichoderma sp. PR-35, an endophytic fungus isolated from Paeonia delavayi. Their structures were elucidated on the basis of their IR, MS, and 1D- and 2D-NMR analyses. The antibacterial and antifungal activities of 1-5 towards various types of bacteria and fungi were tested. Most of the compounds showed moderate or weak antimicrobial activities in an agar-diffusion assay. PMID: 21922660 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229961 Thu, 01 Sep 2011 04:00:00 +0100 5229961 http://www.medworm.com/index.php?rid=5229960&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922661%26dopt%3DAbstract Authors: Yan P, Deng Z, van Ofwegen L, Proksch P, Lin W Abstract Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of seven new biscembranoids named lobophytones U-Z(1) (1-7, resp.), together with methyl sartortuoate (8) and nyalolide (9). The structures of the new compounds were elucidated by 1D- and 2D-NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analysis in association with MS and IR data. All compounds were tested against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophage. Lobophytone Z (6) inhibited NO production with an IC(50) value of 2.6 μM. Lobophytone H (1) showed inhibitory activities against the bacteria S. aureus and S. pneumoniae. PMID: 21922661 [PubMed - in process] (Source: ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229960 Thu, 01 Sep 2011 04:00:00 +0100 5229960 http://www.medworm.com/index.php?rid=5229959&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922662%26dopt%3DAbstract Authors: Wu B, Wang J Abstract Chemical investigation of the leaves and roots of Selaginella moellendorfii Hieron has resulted in the isolation and characterization of two new flavone glucosides, 7-O-(β-glucopyranosyl(1→2)-[β-glucopyranosyl(1→6)]-β-glucopyranosyl)flavone-3',4',5,7-tetraol (1) and 7-O-(β-glucopyranosyl(1→2)-[β-glucopyranosyl(1→6)]-β-glucopyranosyl)flavone-4',5,7-triol (2), two new biflavonoids, 2,3-dihydroflavone-5,7,4'-triol-(3'→8″)-flavone-5″,6″,7″,4'''-tetraol (3) and 6-methylflavone-5,7,4'-triol-(3'→O→4''')-6″-methylflavone-5″,7″-diol (4), two new lignans, (7'E)-3,5,3',5'-tetramethoxy-8 : 4'-oxyneolign-7'-ene-4,9,9'-triol (5) and 3,3'-dimethoxylign-8'-ene-4,4',9-triol (6), together with two known monolignans, four known lign... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229959 Thu, 01 Sep 2011 04:00:00 +0100 5229959 http://www.medworm.com/index.php?rid=5229958&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922663%26dopt%3DAbstract Authors: Gao SS, Li XM, Zhang Y, Li CS, Wang BG Abstract Two new tetracyclic diterpenes of the rarely reported cyclopiane class, conidiogenones H and I (1 and 2, resp.), along with five related congeners, conidiogenones B - D and F (3-5 and 6, resp.) and conidiogenol (7), were characterized from the culture extracts of Penicillium chrysogenum QEN-24S, an endophytic fungus derived from an unidentified marine red algal species of the genus Laurencia. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The inhibitory activity of theses diterpenes against four bacteria and one pathogen fungus was evaluated. Conidiogenone B (3) showed potent activity against Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas fluorescens, P. a... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229958 Thu, 01 Sep 2011 04:00:00 +0100 5229958 http://www.medworm.com/index.php?rid=5229957&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922664%26dopt%3DAbstract This study also demonstrated that the abundance of whitebark pines in Serbia had significantly changed over the last few decades. The number of individuals in the natural population had increased, while the number of individuals in the planted populations had decreased. Today, the whitebark pine fund in Serbia comprises less than 250 trees. PMID: 21922664 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229957 Thu, 01 Sep 2011 04:00:00 +0100 5229957 http://www.medworm.com/index.php?rid=5229956&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922665%26dopt%3DAbstract This study defined for the first time the fingerprint of the sunflower pollen, separated from the disc flowers, to define its contribution to the inflorescence aroma. In the GC/MS fingerprints of the WC and O genotypes, 61 and 62 volatile compounds were identified, respectively. Monoterpene hydrocarbons (34% in O vs. 28% in WC) and sesquiterpene hydrocarbons (37% in O vs. 31% in WC) were ubiquitous in all samples analyzed and represented the main chemical classes. α-Pinene (21% in O vs. 20% in WC) and sabinene (11% in O vs. 6% in WC) were the dominant volatiles, but also a full range of aliphatic hydrocarbons and their oxygenated derivatives gave a decisive contribution to the aroma composition (10% in O vs. 12% in WC). In addition, dendrolasin (3% in O vs. 4% in WC) and some minor consti... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229956 Thu, 01 Sep 2011 04:00:00 +0100 5229956 http://www.medworm.com/index.php?rid=5229955&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922666%26dopt%3DAbstract In this study, the differences in the aroma compounds released after the free-run and pressed juices of cv. Emir grape (Vitis vinifera L.) were evaluated. Aroma compounds were obtained by liquid-liquid extraction with CH(2) Cl(2) , and then analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). According to the results, pressing uniformly increased the levels of the aromatic constituents, but this treatment lowered the grape juice quality for winemaking by increasing the total phenolic compounds, browning index, and C(6) -alcohol levels (green-herbaceaous odor) as compared to the free-run juice. From all the aroma compounds identified in both juices, hexan-1-ol, (E)-hex-2-en-1-ol, isobutanol, isoamyl alcohol, and 2-phenylethanol were the most abundant volatil... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5229955 Thu, 01 Sep 2011 04:00:00 +0100 5229955 http://www.medworm.com/index.php?rid=5052822&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766442%26dopt%3DAbstract Authors: Ha GT, Wong RK, Zhang Y Alzheimer's disease (AD) is the fourth leading cause of death in adults, characterized by hallmark neuritic plaques and neurofibrillary tangles. Current treatments focus only on symptom relief. As a possible new treatment option for AD, huperzine A's chemistry, pharmacology, and clinical effectiveness are assessed. The chemical synthesis of huperzine A has been optimized, while an in vitro technique has provided a renewable plant source. Pharmacological studies showed that the drug inhibits the enzyme acetylcholinesterase reversibly and selectively. Huperzine A also displayed good pharmacokinetics with a rapid absorption and a wide distribution in the body at a low to moderate rate of elimination. Presently, inadequate toxicity data in human have been r... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052822 Thu, 30 Jun 2011 23:00:00 +0100 5052822 http://www.medworm.com/index.php?rid=5052821&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766443%26dopt%3DAbstract Authors: Sun YX, Liu JC PMID: 21766443 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052821 Thu, 30 Jun 2011 23:00:00 +0100 5052821 http://www.medworm.com/index.php?rid=5052820&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766444%26dopt%3DAbstract Authors: Xu WC, Shen JG, Jiang JQ PMID: 21766444 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052820 Thu, 30 Jun 2011 23:00:00 +0100 5052820 http://www.medworm.com/index.php?rid=5052819&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766445%26dopt%3DAbstract Authors: Gao X, Zhao PH, Hu JF PMID: 21766445 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052819 Thu, 30 Jun 2011 23:00:00 +0100 5052819 http://www.medworm.com/index.php?rid=5052818&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766446%26dopt%3DAbstract Authors: Rabindra Reddy P, Shilpa A Dinuclear Cu(II) complexes, [Cu(2) (salophen)(2) ] (1) and [Cu(2) (salen)(2) ] (2), with Schiff bases derived from salicylaldehyde and o-phenylenediamine (ophen) or ethylenediamine (en) were synthesized and characterized. They exhibit square-planar geometry with CuN(2) O(2) coordination, where the dianionic Schiff base acts as a tetradentate N(2) O(2) donor ligand. Calf thymus (CT)-DNA Binding studies revealed that the complexes possess good binding propensities (K(b) =3.13×10(5) for 1 and K(b) =2.99×10(5)  M(-1) for 2). They show good DNA-cleavage abilities under oxidative and hydrolytic conditions. Complex 1 binds and cleaves DNA more efficiently as compared to 2 due to the presence of an extended aromatic phenyl ring which might be involved in... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052818 Thu, 30 Jun 2011 23:00:00 +0100 5052818 http://www.medworm.com/index.php?rid=5052817&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766447%26dopt%3DAbstract Authors: Guo W, Miao Z, Sheng C, Yao J, Liu W, Zhu L, Zhang Y, Cheng P, Dong G, Zhuang C, Zhang W Six 9-(heteroarylmethylidene)amino derivatives, 2a-2f, of homocamptothecin were synthesized for the first time by total synthesis in 22 steps and biologically evaluated as inhibitors of topoisomerase I. Moreover, the antitumor activities of 2a-2f against three human tumor cell lines, i.e., A-549, MDA-MB-435, and HCT-116, were determined and the results showed that compound 2c was the most active homocamptothecin derivative against the A-549 (IC(50) =0.046 μM) and HTC-116 tumor cells (IC(50) =3.67 μM), with a ca. 50 times higher activity than the reference drug topotecan (TPT) against the lung cancer cell line A-549. PMID: 21766447 [PubMed - in process] (Source: Chemistry and Biod... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052817 Thu, 30 Jun 2011 23:00:00 +0100 5052817 http://www.medworm.com/index.php?rid=5052816&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766448%26dopt%3DAbstract Authors: Valachová K, Vargová A, Rapta P, Hrabárová E, Dráfi F, Bauerová K, Juránek I, Soltés L The potential anti- or pro-oxidative effects of a disease-modifying antirheumatic drug, aurothiomalate, to protect high-molar-mass hyaluronan against radical degradation were investigated along with L-glutathione - tested in similar functions. Hyaluronan degradation was induced by the oxidative system Cu(II) plus ascorbate known as the Weissberger's oxidative system. The time- and dose-dependent changes of the dynamic viscosity of the hyaluronan solutions were studied by the method of rotational viscometry. Additionally, the antioxidative activity of aurothiomalate expressed as a radical-scavenging capacity based on a decolorization 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic aci... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052816 Thu, 30 Jun 2011 23:00:00 +0100 5052816 http://www.medworm.com/index.php?rid=5052815&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766449%26dopt%3DAbstract Authors: Makarov SE, Curčić BP, Vujisić LV, Jadranin MB, Tešević VV, Vučković IM, Sekulić TL, Curčić SB, Mitić BM The small millipede Callipodella fasciata secretes an earthy smell when disturbed. This secretion was obtained by CH(2) Cl(2) extraction from specimens of both sexes and was identified by GC/MS analyses to be composed of p-cresol (96.5%), phenol (3.5%), and p-ethylphenol (traces). This is the first identification of these compounds in an epigean European callipodidan species and the first report of intergeneric differences in the chemical composition of defensive secretions in callipodidans. These compounds have repellent, antimicrobial, and antifungal properties. PMID: 21766449 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052815 Thu, 30 Jun 2011 23:00:00 +0100 5052815 http://www.medworm.com/index.php?rid=5052814&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766450%26dopt%3DAbstract Authors: Bansal R, Kumar G, Gandhi D, Young LC, Harvey AL A new series of 1H-imidazol-1-yl substituted 8-phenylxanthine analogs has been synthesized to study the effects of the imidazole group on the binding affinity of compounds for adenosine receptors. Competition binding studies of these compounds were carried out in vitro with human cloned receptors using [(3) H]DPCPX and [(3) H]ZM 241385 as radioligands at A(1) and A(2A) adenosine receptors, respectively. The effect of the substitution pattern of the (imidazolyl)alkoxy group on various positions of the phenyl ring at C(8) was also studied. The xanthine derivatives displayed varying degrees of affinity and selectivity towards A(1) and A(2A) receptor subtypes despite a common but variedly substituted ArC(8). PMID: 21766450 [P... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052814 Thu, 30 Jun 2011 23:00:00 +0100 5052814 http://www.medworm.com/index.php?rid=5052813&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766451%26dopt%3DAbstract Authors: Ponou BK, Teponno RB, Ricciutelli M, Nguelefack TB, Quassinti L, Bramucci M, Lupidi G, Barboni L, Tapondjou LA Two new oleanane-type triterpenes named ivorengenin A (=3-oxo-2α,19α,24-trihydroxyolean-12-en-28-oic acid; 1) and ivorengenin B (=4-oxo-19α-hydroxy-3,24-dinor-2,4-secoolean-12-ene-2,28-dioic acid; 2), together with five known compounds, arjungenin, arjunic acid, betulinic acid, sericic acid, and oleanolic acid, were isolated from the barks of Terminalia ivorensis A. Chev. (Combretaceae). Their structures were established on the basis of 1D- and 2D-NMR data, and mass spectrometry. A biogenetic pathway to the formation of these compounds from sericic acid, isolated as the major compound from this plant, was proposed. The antioxidant activities of different compounds ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052813 Thu, 30 Jun 2011 23:00:00 +0100 5052813 http://www.medworm.com/index.php?rid=5052812&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766452%26dopt%3DAbstract Authors: Lin YS, Eid Fazary A, Chen CH, Kuo YH, Shen YC Chemical investigation of the Taiwanese soft coral Asterospicularia laurae has led to the isolation of three new xenicane diterpenoids, named asterolaurins K-M (1-3, resp.). Their chemical structures were determined through extensive spectroscopic analyses ((1) H- and (13) C-NMR, (1) H,(1) H-COSY, HMBC, and NOESY). Compound 2 exhibited cytotoxic activity against HEp-2, Daoy, MCF-7, and WiDr tumor cells. PMID: 21766452 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052812 Thu, 30 Jun 2011 23:00:00 +0100 5052812 http://www.medworm.com/index.php?rid=5052811&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766453%26dopt%3DAbstract Authors: Caldés C, Vilanova B, Adrover M, Muñoz F, Donoso J Pyridoxamine (PM), a natural derivative of vitamin B(6) , possesses a high biological and biomedical significance by virtue of its acting as enzyme cofactor in amino acid metabolism and as inhibitor in the nonenzymatic glycation of proteins. Both types of processes require the initial formation of a Schiff base. In this work, we used NMR spectroscopy to study the formation mechanism for a Schiff base between PM and formaldehyde (FA). This allowed the Schiff base and an intermediate carbinolamine (CA) to be detected. The Schiff base was found to be in isomeric equilibrium with a hemiaminal (HE) form. The formation equilibrium constants for the CA and HE over the pD range of 6.0-13.0 were determined and compared with those for... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052811 Thu, 30 Jun 2011 23:00:00 +0100 5052811 http://www.medworm.com/index.php?rid=5052810&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766454%26dopt%3DAbstract Authors: Wang Y, Dai P, Chen F, Yang Z The capacity of the ternary complex copper(II)1,10-phenanthrolineL-serine ([CuPhenSer]) to induce double-strand scission of DNA was explored by agarose-gel electrophoresis. It was found that the complex exhibited remarkable activity to damage DNA in the presence of rutin. Analysis of the UV and fluorescence spectra clearly demonstrated that the complex was bound to DNA by intercalation. Further, the occurrence of 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, after the treatment of DNA by the complex in presence of rutin was evidenced by an electrochemical method. Finally, the mechanism of oxidative damage to double-stranded DNA by the [CuPhenSer] complex in the presence of rutin was discussed. PMID: 2... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052810 Thu, 30 Jun 2011 23:00:00 +0100 5052810 http://www.medworm.com/index.php?rid=5052809&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21766455%26dopt%3DAbstract Authors: Damien Dorman HJ, Shikov AN, Pozharitskaya ON, Hiltunen R Using spectrophotometric methods, a H(2) O-soluble Potentilla alba L. rhizome extract was evaluated phytochemically, i.e., the total phenol, flavonoid, flavonol, flavanone, and proanthocyanidin contents were determined, and its antioxidant and pro-oxidant properties, i.e., the Fe(III) reductive and the Fe(II) chelating properties, the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH(.) ), N,N-dimethyl-p-phenylenediamine (DMPD(.+) ), and superoxide anion radical (O$\rm{{_{2}^{{^\cdot} -}}}$)-scavenging activities, the capacity to inhibit hydroxyl radical (HO(.) )-mediated deoxy-D-ribose and phospholipid degradation, and the interaction with the Cu-catalyzed HO(.) -mediated DNA degradation, were determined. The extract was fou... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=5052809 Thu, 30 Jun 2011 23:00:00 +0100 5052809 http://www.medworm.com/index.php?rid=4960709&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674775%26dopt%3DAbstract Authors: Montaut S, Bleeker RS PMID: 21674775 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960709 Tue, 31 May 2011 23:00:00 +0100 4960709 http://www.medworm.com/index.php?rid=4960708&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674776%26dopt%3DAbstract Authors: Yao X, Peng Y, Xu LJ, Li L, Wu QL, Xiao PG PMID: 21674776 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960708 Tue, 31 May 2011 23:00:00 +0100 4960708 http://www.medworm.com/index.php?rid=4960707&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674777%26dopt%3DAbstract Authors: Hu J, Yang B, Lin X, Zhou X, Yang X, Long L, Liu Y PMID: 21674777 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960707 Tue, 31 May 2011 23:00:00 +0100 4960707 http://www.medworm.com/index.php?rid=4960706&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674778%26dopt%3DAbstract Authors: Dixson DD, Boddy CN, Doyle RP There is considerable current interest in coenzyme Q10 (CoQ10) from a medical perspective. CoQ10 has been shown to alleviate the side effects of statin drugs, for instance, and so there is a push to find naturally high producers of the compound. Sporidiobolus johnsonii (S. johnsonii) has been reported to produce CoQ10 in studies that used only standards on thin-layer chromatography (TLC) and also suggested the production of coenzyme Q9 (CoQ9). This work set out to verify CoQ9/CoQ10 production in S. johnsonii and quantify as appropriate. We show that S. johnsonii produces CoQ10 but found no evidence for CoQ9 biosynthesis. The specific production of CoQ10 was noted at 10 mg/g dry cell weight (DCW) in media supplemented with 4-hydroxybenzoic acid (... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960706 Tue, 31 May 2011 23:00:00 +0100 4960706 http://www.medworm.com/index.php?rid=4960705&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674779%26dopt%3DAbstract Authors: Zhou X, Chen YD, Wang T, Wang XB, Kong LY According to a three-point pharmacophore for some uro-selective α(1) -adrenoceptor (AR) antagonists, a novel class of coumarin (=2H-1-benzopyran-2-one) derivatives have been successfully designed and synthesized with high efficacies for α(1) -AR. These synthesized coumarin derivatives exhibited high efficacies towards α(1) -AR in in vitro pharmacological assays. Compared with prazosin (pK(i) value of 8.77), among those coumarins, tolylpiperazine-substituted derivatives, 7 and 8, have comparable pK(i) values of 8.81 and 8.77, respectively. The trend in efficacies of these coumarin derivatives towards α(1A) -adrenoceptor was further rationalized by intensive molecular docking. Our work demonstrated that the designed coumarin derivati... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960705 Tue, 31 May 2011 23:00:00 +0100 4960705 http://www.medworm.com/index.php?rid=4960704&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674780%26dopt%3DAbstract Authors: Tamir H, Satovic Z, Gorelick J, Danin A, Fischer R, Chaimovitsh D, Dudai N Chiliadenus iphionoides (Asteraceae), a shrub endemic to the Mediterranean region and widespread throughout Israel, is used in the traditional eastern Mediterranean medicine. Although recent research confirmed its pharmacological potential, C. iphionoides essential oil has not been adequately characterized chemically. Essential-oil samples were collected from representative wild populations throughout Israel and characterized by GC/MS analysis. Considerable interpopulation variation was found for the composition of the essential oils. Multivariate analysis showed a significant correlation between the chemical composition and the geographic location, with three main chemotypes identified. PMID: 21674... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960704 Tue, 31 May 2011 23:00:00 +0100 4960704 http://www.medworm.com/index.php?rid=4960703&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674781%26dopt%3DAbstract Authors: Chen YJ, Lin CY, Cheng SS, Chang ST The species differentiation between Chamaecyparis formosensis, C. obtusa var. formosana, and C. obtusa, based on the composition of the leaf essential oils, was studied. The characterization of the oils by GC-FID and GC/MS analyses showed remarkable differences between these three essential oils. Cluster analysis (CA) and principal-component analysis (PCA) distinguished three groups of essential oils. The C. formosensis oil was dominated by α-pinene while those isolated from C. obtusa var. formosana and C. obtusa were characterized by high levels of (-)-thujopsene and α-terpinyl acetate, respectively. Moreover, the phylogenetic relationships of the genus Chamaecyparis were in agreement with previous findings based on morphological and mole... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960703 Tue, 31 May 2011 23:00:00 +0100 4960703 http://www.medworm.com/index.php?rid=4960702&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674782%26dopt%3DAbstract Authors: Plano MF, Labadie GR, Jacob MR, Tekwani BL, Cravero RM Analogs of curcuphenol/elvirol, naturally occurring bisabolane sesquiterpenes, were prepared in six steps from alkyl-α-tetralones employing an aromatization reaction of cyclic dienone precursors and olefination of the key aldehyde intermediates. The in vitro antifungal activities of 6a, 6b, 6d, and 6g are also reported. PMID: 21674782 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960702 Tue, 31 May 2011 23:00:00 +0100 4960702 http://www.medworm.com/index.php?rid=4960701&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674783%26dopt%3DAbstract Authors: Li MC, Yao Z, Takaishi Y, Tang SA, Duan HQ We isolated seven novel compounds, namely, 3',4',6-trihydroxy-2,4-dimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (1), 3',6-dihydroxy-2,4,4'-trimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (2), α,β-dihydro-3',6-dihydroxy-2,4,6'-trimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (3), 3',4,4'-trihydroxy-2,6-dimethoxychalcone (4), 4',5,7-trihydroxy-6-(3″,4″-dihydroxybenzyl)flavone (5), 3-(3',4'-dihydroxybenzyl)-6,7-dihydroxycoumarin (6), 3-(3',4'-dihydroxyphenyl)-3,4-dihydroisocoumarin (7), as well as a known compound, 3',4',7-trihydroxy-5-methoxyflavanone (8) from the whole grass of Onychium japonicum, and elucidated their structures by spectroscopic methods. Compounds 1-3 exhibited significant multidrug resistance (MDR) reversal e... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960701 Tue, 31 May 2011 23:00:00 +0100 4960701 http://www.medworm.com/index.php?rid=4960700&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674784%26dopt%3DAbstract Authors: Xu SF, Ye YP, Li XY, Chen FY The total crude polysaccharides (CADPs), isolated from the roots of Angelica dahurica by H(2) O extraction, EtOH precipitation, and dialysis, and the four fractions ADP1, ADP2, ADP3, and ADP4, obtained by gel filtration of the CADPs, were analyzed to characterize their composition and evaluated for their antioxidant activity using different in vitro tests such as the malondialdehyde (MDA)-production, the ferrous ion (Fe(2+) )-chelating, and the HO(.) radical-scavenging assays. The predominant neutral monosaccharides in the four fractions were identified as arabinose, galactose, and glucose, while the composition and ratio of the monosaccharides were different between the fractions. The CADPs and its fractions were found to significantly inhibit lip... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960700 Tue, 31 May 2011 23:00:00 +0100 4960700 http://www.medworm.com/index.php?rid=4960699&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674785%26dopt%3DAbstract Authors: Satou T, Matsuura M, Takahashi M, Murakami S, Hayashi S, Sadamoto K, Koike K The essential oils extracted from the leaves and the shoots of five Abies species (Pinaceae) growing in Japan, i.e., A. firma, A. homolepis, A. veitchii, A. mariesii, and A. sachalinensis, were characterized by GC-FID and GC/MS analyses. The yields of the essential oils extracted from A. sachalinensis were the highest among them. A significant amount of α-pinene was contained in the essential oils of all the Abies species examined. In A. homolepis and A. veitchii, significant differences in the content of the essential oils were found depending on whether these were extracted from the leaves or from the shoots. Regarding the enantiomeric ratio of α-pinene, the (+)-enantiomer was predominant in the o... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960699 Tue, 31 May 2011 23:00:00 +0100 4960699 http://www.medworm.com/index.php?rid=4960698&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674786%26dopt%3DAbstract Authors: Brahmachari G, Mandal NC, Jash SK, Roy R, Mandal LC, Mukhopadhyay A, Behera B, Majhi S, Mondal A, Gangopadhyay A The antimicrobial potential of two bioflavonoids, i.e., 5,7-dihydroxy-4',6,8-trimethoxyflavone (1) and 5,6-dihydroxy-4',7,8-trimethoxyflavone (2), isolated from Limnophila heterophylla Benth. and L. indica (Linn.) Druce (Scrophulariaceae), respectively, were evaluated against the microbial strains Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Alternaria solani, and Candida albicans. Compounds 1 and 2 exhibited moderate but broad antimicrobial activities against both Gram-positive and Gram-negative bacteria and also against the fungal pathogens. Moreover, the mechanism of action of 1 and 2 on the cellular functions or structures ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960698 Tue, 31 May 2011 23:00:00 +0100 4960698 http://www.medworm.com/index.php?rid=4960697&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674787%26dopt%3DAbstract Authors: Tundis R, Loizzo MR, Menichini F, Bonesi M, Colica C, Menichini F In the course of recent efforts to identify new potential antiproliferative active principles, Salvia leriifolia extracts and isolated constituents were evaluated for their cytotoxic activity against a panel of human cancer cell lines, including renal adenocarcinoma (ACHN), amelanotic melanoma (C32), colorectal adenocarcinoma (Caco-2), lung large cell carcinoma (COR-L23), malignant melanoma (A375), lung carcinoma (A549), and hepatocellular carcinoma (Huh-7D12) cells. The hexane and CH(2) Cl(2) extracts showed the strongest cytotoxic activity against the C32 cell line with IC(50) values of 11.2 and 13.6 μg/ml, respectively, and the AcOEt extract was the most active extract against the COR-L23 cell line (IC(50)... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960697 Tue, 31 May 2011 23:00:00 +0100 4960697 http://www.medworm.com/index.php?rid=4960696&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674788%26dopt%3DAbstract Authors: Jiao WH, Gao H, Zhao F, He F, Zhou GX, Yao XS A new dihydrobenzofuran-type neolignan, picrasmalignan A (1), and a new sesterterpene lactone, 2'-isopicrasin A (4), were isolated from the stems of Picrasma quassioides Bennet, along with four known compounds, comprising two neolignans, 2 and 3, a sesterterpene lactone, 5, and a flavonol, 6. The structures of these compounds were determined by detailed analysis of NMR and MS data, and comparison with the literature data. Compounds 1-6 were tested for their anti-inflammatory activity, and 1-3 and 6 showed potent inhibitory activities on nitric oxide, tumor necrosis factor-α, and interleukin-6 production in mouse monocyte-macrophage RAW 264.7 stimulated by lipopolysaccharide (LPS). PMID: 21674788 [PubMed - in process] (Source: ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960696 Tue, 31 May 2011 23:00:00 +0100 4960696 http://www.medworm.com/index.php?rid=4960695&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674789%26dopt%3DAbstract Authors: Radonić A, Blažević I, Mastelić J, Zekić M, Skočibušić M, Maravić A Two different volatile isolates from the aerial parts of Cardaria draba (L.) Desv., obtained either by hydrodistillation (Extract I) or by CH(2) Cl(2) extraction subsequent to hydrolysis by exogenous myrosinase (Extract II), were characterized by GC-FID and GC/MS analyses. The main volatiles obtained by hydrodistillation, i.e., 4-(methylsulfanyl)butyl isothiocyanate (1; 28.0%) and 5-(methylsulfanyl)pentanenitrile (2; 13.8%), originated from the degradation of glucoerucin. In Extract I, also volatiles without sulfur and/or nitrogen were identified. These were mostly hexadecanoic acid (10.8%), phytol (10.2%), dibutyl phthalate (4.5%), and some other compounds in smaller percentages. Extract II contained... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960695 Tue, 31 May 2011 23:00:00 +0100 4960695 http://www.medworm.com/index.php?rid=4960694&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674790%26dopt%3DAbstract Authors: Wu ZY, Li HZ, Wang WG, Li HM, Chen R, Li RT, Luo HR Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyses. Compound 1 turned out to be a new, highly O-acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 μM induced a significantly decreased cAMP level in N1E-115 neuroblastoma cells (p<0.001), indicating neuroph... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4960694 Tue, 31 May 2011 23:00:00 +0100 4960694 http://www.medworm.com/index.php?rid=4863178&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560227%26dopt%3DAbstract Authors: Seebach D, Lukaszuk A, Patora-Komisarska K, Podwysocka D, Gardiner J, Ebert MO, Reubi JC, Cescato R, Waser B, Gmeiner P, Hübner H, Rougeot C The terminal homologation by CH(2) insertion into the peptides mentioned in the title is described. This involves replacement of the N-terminal amino acid residue by a β(2) - and of the C-terminal amino acid residue by a β(3) -homo-amino acid moiety (β(2) hXaa and β(3) hXaa, resp.; Fig. 1). In this way, the structure of the peptide chain from the N-terminal to the C-terminal stereogenic center is identical, and the modified peptide is protected against cleavage by exopeptidases (Figs. 2 and 3). Neurotensin (NT; 1) and its C-terminal fragment NT(8-13) are ligands of the G-protein-coupled receptors (GPCR) NT1, NT2, NT3, and NT anal... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863178 Sat, 30 Apr 2011 23:00:00 +0100 4863178 http://www.medworm.com/index.php?rid=4863177&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560228%26dopt%3DAbstract Authors: Dong G, Xu T, Yang B, Lin X, Zhou X, Yang X, Liu Y Starfish have been the research topic in many chemical and pharmacological laboratories due to their complex secondary metabolites and diverse bioactivities. The aim of this review is to provide an up-to-date review on the chemistry and bioactivity of compounds isolated from all kinds of starfish to illustrate the chemodiversity and biological significance of these constituents, along with their geographical distribution where it is discernible. PMID: 21560228 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863177 Sat, 30 Apr 2011 23:00:00 +0100 4863177 http://www.medworm.com/index.php?rid=4863176&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560229%26dopt%3DAbstract Authors: Qiang Y, Zhou B, Gao K PMID: 21560229 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863176 Sat, 30 Apr 2011 23:00:00 +0100 4863176 http://www.medworm.com/index.php?rid=4863175&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560230%26dopt%3DAbstract Authors: Pietra F Investigated here are interactions of C-terminal amidated peptides with the hASIC1a acid-sensing ion channel. The peptides comprise endogenous FMRFa, present in the western Atlantic clam Sunray Venus, and FIRFa, present in cephalopods, as well as non-endogenous ones for comparison. The interaction is investigated by automated docking. The resulting key hASIC1aFMRFa complex, set in a lipidic POPC (=1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) membrane surrounded by H(2) O and Na(+) -neutralized, was also investigated by molecular dynamics. It was observed that all investigated peptides become encapsulated into the ion channel, on one side by the thumb and finger of a subunit, and, on the opposite side, by the knuckle and β-ball of a second subunit. The third s... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863175 Sat, 30 Apr 2011 23:00:00 +0100 4863175 http://www.medworm.com/index.php?rid=4863174&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560231%26dopt%3DAbstract Authors: Zhang Y, Wang MQ, Zhang J, Zhang DW, Lin HH, Yu XQ A novel coumarin-appended PNA binding cyclen derivative ligand, C1, and its copper(II) complex, C2, have been synthesized and characterized. The interaction of these compounds with DNA was systematically investigated by absorption, fluorescence, and viscometric titration, and DNA-melting and gel-electrophoresis experiments. DNA Melting and viscometric titration experiments indicate that the binding mode of C1 is a groove binding, and C2 is a multiple binding mode that involves groove binding and electrostatic binding. From the absorption-titration data, we can state that the primary interaction between CT DNA and the two compounds may be H-bonds between nucleobases. Fluorescence studies indicate that the binding ability of C1 ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863174 Sat, 30 Apr 2011 23:00:00 +0100 4863174 http://www.medworm.com/index.php?rid=4863173&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560232%26dopt%3DAbstract Authors: Khandare RP, Vaze KR, Bhat SV New retinobenzoic acid derivatives have been synthesized starting from 1,2,3,4-tetrahydro-1,1,2,4,4,6-hexamethylnaphthalene and 1,1,2,3,3-pentamethylindane. Four of the synthetic compounds displayed potent cytotoxic activities in vitro against human breast cancer and leukemic cell lines. Thus, these molecules can be further evaluated for the treatment of human leukemia and breast cancer. PMID: 21560232 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863173 Sat, 30 Apr 2011 23:00:00 +0100 4863173 http://www.medworm.com/index.php?rid=4863172&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560233%26dopt%3DAbstract Authors: Begum S, Perwaiz S, Siddiqui BS, Khan S, Fayyaz S, Ramzan M Following nematicidal activity-guided isolation studies on the fruits, bark, and leaves of Cordia latifolia, two new constituents, cordinoic acid (=11-oxours-12-ene-23,28-dioic acid; 1) and cordicilin (=2-{[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-3-[4-hydroxy-3-(stearoyloxy)phenyl]propanoic acid; 2) were isolated from the stem and leaves, respectively, together with nine known compounds, namely cordioic and cordifolic acid from the stem bark, latifolicin A-D and rosmarinic acid from the fruits, and cordinol and cordicinol from the leaves. Their structures were determined by means of spectroscopic analyses including 1D- and 2D-NMR techniques. The nematicidal activities of these constituents were determined against... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863172 Sat, 30 Apr 2011 23:00:00 +0100 4863172 http://www.medworm.com/index.php?rid=4863171&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560234%26dopt%3DAbstract Authors: Lin MG, Yu DH, Wang QW, Lu Q, Zhu WJ, Bai F, Li GX, Wang XW, Yang YF, Qin XM, Fang C, Chen HZ, Yang GH Two new secolignans, peperomins G and H (1 and 2, resp.), were isolated from the whole plant of Peperomia dindygulensis, together with five known secolignans, peperomin A (3), peperomin E (4), peperomin B (5), 2,3-trans-2-methyl-3-{(3-hydroxy-4,5-dimethoxyphenyl)[5-methoxy-3,4-(methylenedioxy)phenyl]methyl}butyrolactone (6), 2,3-cis-2-(hydroxymethyl)-3-{bis[5-methoxy-3,4-(methylenedioxy)phenyl]methyl}butyrolactone (7). Their structures and configurations were elucidated by spectroscopic methods including 2D-NMR techniques. Antiangiogenic effects of all compounds were evaluated using human umbilical vein endothelial cells (HUVEC) proliferation and tube-formation tests, with co... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863171 Sat, 30 Apr 2011 23:00:00 +0100 4863171 http://www.medworm.com/index.php?rid=4863170&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560235%26dopt%3DAbstract Authors: Tuberoso CI, Jerković I, Bifulco E, Marijanović Z Rare unifloral willow (Salix spp.) honeys obtained from nectar or honeydew were investigated by direct RP-HPLC-DAD method in order to identify and quantify compounds that can be used as possible markers of their origin. Antioxidant and antiradical activities of willow honeys were evaluated using FRAP (=ferric reducing antioxidant assay) and DPPH (=1,1-diphenyl-2-picrylhydrazyl radical) tests, respectively. Also HMF (=5-(hydroxymethyl)furfural), diastase activity, and CIE L*a*b*C*h* chromatic coordinates were evaluated. Abscisic acids (ABA) are typical of willow nectar honey, with a predominance of (Z,E)-ABA on (E,E)-ABA (98.2 and 31.7 mg/kg, resp.). Kinurenic acid and salicylic acid are useful to mark willow honeydew honey.... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863170 Sat, 30 Apr 2011 23:00:00 +0100 4863170 http://www.medworm.com/index.php?rid=4863169&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560236%26dopt%3DAbstract Authors: Huang HY, Ishikawa T, Peng CF, Chen S, Chen IS Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of five new compounds, wutaipyranol A (1), 8-methoxywutaipyranol A (2), demethoxywutaiensal (3), demethoxywutaiensol (4), and dihydrodemethoxywutaiensol (5), together with six known compounds. Their structures were elucidated by 1D- and 2D-NMR, as well as MS analyses. Among the isolates, wutaipyranol A (1), 8-methoxywutaipyranol A (2), and demethoxywutaiensal (3) exhibited antitubercular activities against Mycobacterium tuberculosis H(37) Rv in vitro, with MIC values of 52.4, 55.6, and 45.8 μg/ml, respectively. PMID: 21560236 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863169 Sat, 30 Apr 2011 23:00:00 +0100 4863169 http://www.medworm.com/index.php?rid=4863168&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560237%26dopt%3DAbstract Authors: Wang FZ, Wei HJ, Zhu TJ, Li DH, Lin ZJ, Gu QQ Three new cytochalasins Z(21) -Z(23) (1-3, resp.), together with five analogs, 4-8, were isolated from Spicaria elegans KLA03 by the OSMAC (one strain-many compounds) approach with adding L- and D-tryptophan during its cultivation. The structures of new cytochalasins were elucidated on the basis of comprehensive 1D- and 2D-NMR and HR-ESI-MS analyses. Cytochalasins Z(21) and Z(22) (1 and 2, resp.), and compound 5 showed cytotoxic activities against A-549 cell lines with IC(50) values of 8.2, 20.0, and 3.1 μM, respectively. PMID: 21560237 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863168 Sat, 30 Apr 2011 23:00:00 +0100 4863168 http://www.medworm.com/index.php?rid=4863167&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560238%26dopt%3DAbstract Authors: Li DH, Cai SX, Zhu TJ, Wang FP, Xiao X, Gu QQ Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5±1.4, 0.1±0.1, and 0.2±0.01 μM, resp.) and K562 (IC(50) values of 22.9±0.8, 4.8±0.3 and 22.4±0.9 μM, resp.) cell lines. PMID: 21560238 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863167 Sat, 30 Apr 2011 23:00:00 +0100 4863167 http://www.medworm.com/index.php?rid=4863166&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560239%26dopt%3DAbstract Authors: Hadian J, Hossein Mirjalili M, Reza Kanani M, Salehnia A, Ganjipoor P Satureja khuzistanica is an endemic herb growing wild in Iran with interesting pharmacological and biological properties. Here, as an initial step of the domestication process, the variability of phytochemical and morphological traits among 69 individuals of eight natural populations of the plant was studied. The investigated characteristics were the essential oil content and composition, the rosmarinic acid (RA) content, and the leaf and flower morphologies. The Abdanan and Kaver populations showed the highest oil contents. The characterization by GC-FID and GC/MS analyses of the oils revealed that all 69 sampled individuals had carvacrol as the main component with very high contents (89.59-95.41%). The con... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863166 Sat, 30 Apr 2011 23:00:00 +0100 4863166 http://www.medworm.com/index.php?rid=4863165&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560240%26dopt%3DAbstract Authors: Yusoff MM, Ibrahim H, Hamid NA Two poorly studied, morphologically allied Alpinia species endemic to Borneo, viz., A. ligulata and A. nieuwenhuizii, were investigated here for their rhizome essential oil. The oil compositions and antimicrobial activities were compared with those of A. galanga, a better known plant. A fair number of compounds were identified in the oils by GC-FID and GC/MS analyses, with large differences in the oil composition between the three species. The rhizome oil of A. galanga was rich in 1,8-cineole (29.8%), while those of A. ligulata and A. nieuwenhuizii were both found to be extremely rich in (E)-methyl cinnamate (36.4 and 67.8%, resp.). The three oils were screened for their antimicrobial activity against three Gram-positive and three Gram-negative b... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863165 Sat, 30 Apr 2011 23:00:00 +0100 4863165 http://www.medworm.com/index.php?rid=4863164&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560241%26dopt%3DAbstract Authors: Lima B, López S, Luna L, Agüero MB, Aragón L, Tapia A, Zacchino S, López ML, Zygadlo J, Feresin GE The antifungal, antibacterial, and insect-repellent activities of the essential oils (EOs) of Acantholippia seriphioides, Artemisia mendozana, Gymnophyton polycephalum, Satureja parvifolia, Tagetes mendocina, and Lippia integrifolia, collected in the Central Andes area, province of San Juan, Argentina, were investigated. The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes, and T. rubrum were inhibited by the EOs of G. polycephalum, L. integrifolia, and S. parvifolia, with minimum inhibitory concentrations (MICs) between 31.2 and 1000 μg/ml. Moreover, all EOs presented moderate activity against the bacteria tested, and the L. integrifolia and G. polycephalum ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863164 Sat, 30 Apr 2011 23:00:00 +0100 4863164 http://www.medworm.com/index.php?rid=4863163&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560242%26dopt%3DAbstract Authors: Benabdelkader T, Zitouni A, Guitton Y, Jullien F, Maitre D, Casabianca H, Legendre L, Kameli A In an effort to develop local productions of aromatic and medicinal plants, a comprehensive assessment of the composition and biological activities of the essential oils (EOs) extracted from the aerial flowering parts of wild growing Lavandula stoechas L. collected from eleven different locations in northern Algeria was performed. The oils were characterized by GC-FID and GC/MS analyses, and 121 compounds were identified, accounting for 69.88-91.2% of the total oil compositions. The eleven oils greatly differed in their compositions, since only 66 compounds were common to all oils. Major EO components were fenchone (2; 11.27-37.48%), camphor (3, 1.94-21.8%), 1,8-cineole (1; 0.16-8.71... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4863163 Sat, 30 Apr 2011 23:00:00 +0100 4863163 http://www.medworm.com/index.php?rid=4806572&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480502%26dopt%3DAbstract Authors: Wang DL, Qi FH, Tang W, Wang FS PMID: 21480502 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806572 Thu, 31 Mar 2011 23:00:00 +0100 4806572 http://www.medworm.com/index.php?rid=4806571&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480503%26dopt%3DAbstract Authors: Kolganova NA, Florentiev VL, Chudinov AV, Zasedatelev AS, Timofeev EN A simple and stereoselective synthesis of a protected 4-(aminomethyl)-1-(2-deoxy-β-D-ribofuranosyl)-1,2,3-triazole cyanoethyl phosphoramidite was developed for the modification of synthetic oligonucleotides. The configuration of the 1,2,3-triazolyl moiety with respect to the deoxyribose was unambiguously determined in ROESY experiments. The aminomethyl group of the triazolyl nucleotide was fully functional in labelling reactions. Furthermore, the hybridization behavior of 5' triazole-terminated oligonucleotide was similar to that of 5' aminohexyl-terminated oligomer with the same sequence. Internal modifications of the oligonucleotide strands resulted in significant decrease of duplex stability. PMID: 2... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806571 Thu, 31 Mar 2011 23:00:00 +0100 4806571 http://www.medworm.com/index.php?rid=4806566&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480504%26dopt%3DAbstract Authors: Piskorski R, Kroder S, Dorn S Chemical analysis of putative contact chemical cues for pollinators from pollen of two plant species, Ranunculus bulbosus (Ranunculaceae) and Campanula rapunculoides (Campanulaceae), showed high consistency in the qualitative and quantitative composition of pollenkitt surface lipids in all samples analyzed per species. The pollenkitt lipids of R. bulbosus included an aldehyde, fatty acid amides, saturated and unsaturated hydrocarbons, and secondary alcohols; the lipids of C. rapunculoides consisted of an aldehyde, monoketones, and β-diketones. In marked contrast, the pollen headspace volatiles showed a wide qualitative and quantitative variability among all samples per species, whereby the variability was more pronounced in R. bulbosus. Hence, th... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806566 Thu, 31 Mar 2011 23:00:00 +0100 4806566 http://www.medworm.com/index.php?rid=4806543&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480505%26dopt%3DAbstract Authors: Jerković I, Tuberoso CI, Kasum A, Marijanović Z PMID: 21480505 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806543 Thu, 31 Mar 2011 23:00:00 +0100 4806543 http://www.medworm.com/index.php?rid=4806536&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480506%26dopt%3DAbstract Authors: Vyas S, Manon B, Vir Singh T, Dev Sharma P, Sharma M (-)-Epicatechin-3-gallate (1) is one of the principal catechins of green tea and exhibits cancer-preventive activities in various animal models. However, this compound is unstable in neutral or alkaline medium and, therefore, has a poor bioavailability. To improve its stability, O-acyl derivatives of 1 were prepared by isolating the partially purified tea catechin fraction from green tea extract and treating it with a variety of acylating agents. The resulting derivatives, compounds 2-6, were screened for their antitumor potential against 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced squamous cell carcinogenesis of skin in mice. The results showed that the antitumor activity decreas... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806536 Thu, 31 Mar 2011 23:00:00 +0100 4806536 http://www.medworm.com/index.php?rid=4806535&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480507%26dopt%3DAbstract This study, therefore, demonstrated the potential use of both oils as source of novel agents for the treatment of leishmaniasis. PMID: 21480507 [PubMed - in process] (Source: Chemistry and Biodiversity) Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806535 Thu, 31 Mar 2011 23:00:00 +0100 4806535 http://www.medworm.com/index.php?rid=4806524&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480508%26dopt%3DAbstract Authors: Guerrini A, Rossi D, Paganetto G, Tognolini M, Muzzoli M, Romagnoli C, Antognoni F, Vertuani S, Medici A, Bruni A, Useli C, Tamburini E, Bruni R, Sacchetti G Chemical fingerprinting of commercial Pelargonium capitatum (Geraniaceae) essential oil samples of south African origin was performed by GC, GC/MS, and (13) C- and (1) H-NMR. Thirty-seven compounds were identified, among which citronellol (32.71%) and geraniol (19.58%) were the most abundant. NMR Spectra of characteristic chemicals were provided. Broad-spectrum bioactivity properties of the oil were evaluated and compared with those of commercial Thymus vulgaris essential oil with the aim to obtain a functional profile in terms of efficacy and safety. P. capitatum essential oil provides a good performance as antimicrobial... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806524 Thu, 31 Mar 2011 23:00:00 +0100 4806524 http://www.medworm.com/index.php?rid=4806523&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480509%26dopt%3DAbstract Authors: Cao S, Hou Y, Brodie P, Miller JS, Randrianaivo R, Rakotobe E, Rasamison VE, Kingston DG Bioassay-guided fractionation of the EtOH extracts obtained from a plant identified as Cyphostemma greveana Desc. (Vitaceae) led to the identification of one macrolide, lasiodiplodin (1), three sesquiterpenoids, 12-hydroxy-15-oxoselina-4,11-diene (2), 1β,6α-dihydroxyeudesm-4(15)-ene (3), and (7R*)-opposit-4(15)-ene-1β,7-diol (5), and a new diterpenoid, 16,18-dihydroxykolavenic acid lactone (4). All the isolates were tested against the A2780 human ovarian cancer cell line, and compound 4 and a fraction containing 5 as the major constituent showed antiproliferative activities with IC(50) values of 0.44 μM (0.14 μg/ml) and 0.045 μg/ml, respectively. A partial synthesis of compound... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806523 Thu, 31 Mar 2011 23:00:00 +0100 4806523 http://www.medworm.com/index.php?rid=4806522&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480510%26dopt%3DAbstract Authors: Kikuchi M, Yaoita Y, Mano N, Kikuchi M Hydrolysis of isoligustroside (1) and isooleuropein (2), secoiridoid glucosides, in the presence of β-glucosidase provided 2-(4-hydroxyphenyl)methyl (2R,3S,4S)-3-formyl-3,4-dihydro-4-(2-methoxy-2-oxoethyl)-2-methyl-2H-pyran-5-carboxylate (3) and 2-(3,4-dihydroxyphenyl)methyl (2R,3S,4S)-3-formyl-3,4-dihydro-4-(2-methoxy-2-oxoethyl)-2-methyl-2H-pyran-5-carboxylate (4), respectively. The structures of 3 and 4 were elucidated on the basis of extensive spectral analyses, including 2D-NMR experiments. Compounds 3 and 4 were found to be new rearrangement products of the aglycones of 1 and 2. The cytotoxic activities of 3 and 4 were evaluated using a disease-oriented panel of 39 human cancer cell lines and showed moderate cytotoxic activity for ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806522 Thu, 31 Mar 2011 23:00:00 +0100 4806522 http://www.medworm.com/index.php?rid=4806521&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480511%26dopt%3DAbstract Authors: Cheikh-Ali Z, Adiko M, Bouttier S, Bories C, Okpekon T, Poupon E, Champy P The essential oil from the rhizomes of Aframomum sceptrum (Zingiberaceae) was analyzed by GC/MS, and its major constituents were found to be β-pinene (12.7%), caryophyllene oxide (10.0%), and cyperene (6.0%). The oil was also evaluated for antimicrobial activities, in comparison with β-pinene, caryophyllene oxide, and the leaf essential oil of Melaleuca alternifolia (Myrtaceae). The A. sceptrum essential oil exhibited bacteriostatic activity against the Gram-positive bacteria Bacillus subtilis, Staphylococcus epidermidis, and S. aureus, but not against Gram-negative bacteria. Moreover, it showed mild fungicidal activity against Candida albicans and Aspergillus fumigates, and remarkable antiprotozoal a... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806521 Thu, 31 Mar 2011 23:00:00 +0100 4806521 http://www.medworm.com/index.php?rid=4806520&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480512%26dopt%3DAbstract Authors: Awang K, Ibrahim H, Rosmy Syamsir D, Mohtar M, Mat Ali R, Azah Mohamad Ali N The essential oils from the leaves and rhizomes of Alpinia pahangensis Ridl., collected from Pahang, Peninsular Malaysia, were obtained by hydrodistillation, and their chemical compositions were determined by GC and GC/MS analyses. The major components of the rhizome oil were γ-selinene (11.60%), β-pinene (10.87%), (E,E)-farnesyl acetate (8.65%), and α-terpineol (6.38%), while those of the leaf oil were β-pinene (39.61%), α-pinene (7.55%), and limonene (4.89%). The investigation of the antimicrobial activity of the essential oils using the broth microdilution technique revealed that the rhizome oil of A. pahangensis inhibited five Staphylococcus aureus strains with minimum inhibitory concentratio... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806520 Thu, 31 Mar 2011 23:00:00 +0100 4806520 http://www.medworm.com/index.php?rid=4806519&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480513%26dopt%3DAbstract Authors: Herrero-Jáuregui C, Casado MA, das Graças Bichara Zoghbi M, Célia Martins-da-Silva R The copaiba tree (Copaifera spp.) produces an oleoresin which is highly valued due to its medicinal properties. The chemical composition of C. reticulata oleoresin was characterized, and its variability related to seasonal variation (dry and rainy seasons), to successive extractions, and to several factors associated with tree morphometry, disease, and surrounding vegetation structure was investigated. Oleoresin was collected from 24 C. reticulata individuals between October 2006 and March 2008. For seven individuals, oleoresin was extracted for a second time between three and nine months after the first extraction. For each tree, several morphometric variables, viz., the presence of termit... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806519 Thu, 31 Mar 2011 23:00:00 +0100 4806519 http://www.medworm.com/index.php?rid=4806518&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480514%26dopt%3DAbstract In this study, we examined the nutritional content and biomass accumulation profiles of two cytotypes, collected from 29 sites, with different altitudinal origins but cultivated in a common garden. On an average, this species has superior qualities in the minerals and amino acids compared to other edible congeners. When compared with the diploids, the tetraploids grew faster and accumulated more biomass; in addition, the tetraploids had higher values of moisture and energy, higher contents of cystine and phosphorus, but lower fiber levels. Moreover, the tetraploids from the higher altitudes had greater biomasses than the other tetraploids, in addition to having increased levels of proteins, fats, and the minerals Mg, Fe, Mn, and Cu. These results illustrate the large variations in nutritio... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806518 Thu, 31 Mar 2011 23:00:00 +0100 4806518 http://www.medworm.com/index.php?rid=4806517&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480515%26dopt%3DAbstract Authors: Liu JF, Jiang ZY, Geng CA, Zhang Q, Shi Y, Ma YB, Zhang XM, Chen JJ Two new lignans, dihydrodehydrodiconiferyl alcohol 9-O-β-D-(3″-O-acetyl)-xylopyranoside (1) and threo-4,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan 7-O-α-rhamnopyranoside (2) were isolated from Illicium henryi, together with ten known compounds, 3-12. Their structures were elucidated by extensive spectroscopic analyses. The anti-hepatitis B virus (anti-HBV) activity of compounds 1-12 inhibiting HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line was evaluated. (-)-Dihydrodehydrodiconiferyl alcohol (4) showed moderate inhibitory activity on both HBsAg and HBeAg secretion with IC(50) values of 0.06 and 0.53 mM, respectively. PMID: 21480515 [PubMed - in process] ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806517 Thu, 31 Mar 2011 23:00:00 +0100 4806517 http://www.medworm.com/index.php?rid=4806516&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480516%26dopt%3DAbstract Authors: Guang Li C, Jun Sheng S, Pang EC, May B, Chang Li Xue C The plant density-dependent variations in the root yield and content, and the yield of biomarkers in Australian grown Salvia miltiorrhiza Bunge, a commonly used Chinese medicinal herb for the treatment of cardiovascular diseases, were investigated in a field trial involving six different plant densities. The key biomarker compounds cryptotanshinone, tanshinone I, tanshinone IIA, and salvianolic acid B were quantified by a validated RP-HPLC method, and the root yields were determined per plant pair or unit area. There were significant variations (p<0.05) in the root yields and contents and the yields of the biomarkers between the different plant densities. Positive linear correlations were observed between the contents ... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4806516 Thu, 31 Mar 2011 23:00:00 +0100 4806516 http://www.medworm.com/index.php?rid=4643270&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21404424%26dopt%3DAbstract Authors: D'Alonzo D, Guaragna A, Palumbo G The study of the base-pairing properties of nucleic acids with sugar moieties in the backbone belonging to the L-series (β-L-DNA, β-L-RNA, and their analogs) are reviewed. The major structural factors underlying the formation of stable heterochiral complexes obtained by incorporation of modified nucleotides into natural duplexes, or by hybridization between homochiral strands of opposite sense of chirality are highlighted. In addition, the perspective use of L-nucleic acids as candidates for various therapeutic applications, or as tools for both synthetic biology and etiology-oriented investigations on the structure and stereochemistry of natural nucleic acids is discussed. PMID: 21404424 [PubMed - in process] (Source: Chemistry and Biod... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4643270 Tue, 01 Mar 2011 00:00:00 +0100 4643270 http://www.medworm.com/index.php?rid=4643269&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21404425%26dopt%3DAbstract Authors: Zhao YM, Shi YP The plants of genus Dipsacus, with a wide distribution in Europe, Asia, and Africa, have been used as medicinal agents to treat several diseases, including lime disease, fibromyalgia, bone fracture, and abortion, and especially the Alzheimer's disease and cancer. A large number of studies on plants of genus Dipsacus has revealed cytoprotective properties, inhibition of HIV-1 reverse transcriptase, antinociceptive, and antimicrobial effects, etc. This review compiles all chemical constituents isolated, mainly triterpenoids, iridoids, phenolics, and alkaloids, from the genus Dipsacus over the past few decades together with their structural features, biological activities, and structureactivity relationships. PMID: 21404425 [PubMed - in process] (Source: Ch... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4643269 Tue, 01 Mar 2011 00:00:00 +0100 4643269 http://www.medworm.com/index.php?rid=4643268&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21404426%26dopt%3DAbstract Authors: Robaa D, Eldin Abulazm S, Lehmann J, Enzensperger C Dibenzazecines are a novel class of dopamine receptor antagonists, characterized by their high affinities as well as their tendency for D(1) selectivity. Hitherto, the most active dibenzazecines were phenolic in nature; a 3-OH substituent was found to result in the highest affinities. However, the phenolic nature of these compounds mostly renders them unsuitable for in vivo application, due to the poor pharmacokinetic profile, imparted by the phenolic group. A novel dibenzazecine derivative was prepared, with methylenedioxy moiety, connecting C(2) amd C(3), instead of the 3-OH group. The newly synthesized derivative 3 showed high affinities similar to the lead LE404, displaying nanomolar affinities for all dopamine receptor s... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4643268 Tue, 01 Mar 2011 00:00:00 +0100 4643268 http://www.medworm.com/index.php?rid=4643267&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21404427%26dopt%3DAbstract Authors: Basak SC, Mills D, Hawkins DM Two classes of graph-theoretic molecular descriptors, viz., topological indices (TIs) and atom pairs (APs), have been used to derive high-quality quantitative structureactivity relationships (QSARs) for inhibitors of dihydrofolate reductases (DHFRs) isolated from the wild and four mutant strains of Plasmodium falciparum. Of the three methods used for QSAR formulation, viz., principal-components regression (PCR), partial least squares (PLS), and ridge regression (RR), the RR method outperformed the other two. Cohen's kappa values, based on the overlap of significant and insignificant structural descriptors calculated for the QSAR development, show that DHFR from the wild strain is substantially different from the four mutant strains. The differe... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4643267 Tue, 01 Mar 2011 00:00:00 +0100 4643267 http://www.medworm.com/index.php?rid=4643266&cid=s_37951_60_f&fid=37951&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21404428%26dopt%3DAbstract Authors: Celik A, Aydınlık N, Arslan I The chemical composition of the essential oils of Eryngium campestre, E. thorifolium, and E. creticum (Apiaceae), growing in the Aegean region of Turkey (Mount Sandras, Denizli), was determined by direct thermal desorption (DTD)-GC/MS analyses. A total of 49 components were identified in the oils, α-pinene and hexanal being the major compounds. The three essential oils were also tested for their inhibitory activity of nine different methicillin-resistant Staphylococcus aureus (MRSA) strains by the agar disc diffusion method. The anti-MRSA activity of E. thorifolium oil, the most active of the three oils, was comparable with those of the reference antibiotic vancomycin and oregano oil, although somewhat lower. PMID: 21404428 [PubMed - in pro... Chemistry and Biodiversity journals http://www.medworm.com/rss/comments.php?id=4643266 Tue, 01 Mar 2011 00:00:00 +0100 4643266