MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Chinese Journal of Digestive Diseases' source. Wed, 08 Feb 2012 16:28:10 +0100 http://www.medworm.com/index.php?rid=5667850&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00581.x Conclusion: Anxiety is more common in IBS compared to FD and NERD, indicating a possible causal link in the former.© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5667850 Mon, 06 Feb 2012 05:00:00 +0100 5667850 http://www.medworm.com/index.php?rid=5667849&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00564.x Conclusions: Palliative SEMS are effective and favorable procedures for malignant colorectal obstruction but have some complications. Stent migration is associated with covered type and small diameter stent and other factors do not affect the stent complication in the present study and adverse events that occurred are manageable.© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5667849 Mon, 06 Feb 2012 05:00:00 +0100 5667849 http://www.medworm.com/index.php?rid=5667848&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00582.x Conclusion: Although some recent advances have been made in helping the diagnosis of AIP, the differentiation of AIP with pancreatic carcinoma is still a challenge. In clinical practice, it must be reminded to exclude AIP before making the diagnosis of pancreatic carcinoma.© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5667848 Mon, 06 Feb 2012 05:00:00 +0100 5667848 http://www.medworm.com/index.php?rid=5667847&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00583.x Conclusion: Patients with IgG4‐related disease of high serum IgG and IgG4 levels should be systematically examined for involved lesions.© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5667847 Wed, 01 Feb 2012 05:00:00 +0100 5667847 http://www.medworm.com/index.php?rid=5609858&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00559.x CONCLUSIONS:  An HPLC method based on strong cation‐exchange restricted access columns for determination of concentration of tryptophan in gastric juice was developed. The method has excellent precision and stability. It is compatible with the analysis of gastric juice and has the potential to be used for gastric cancer screening. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5609858 Fri, 20 Jan 2012 20:55:34 +0100 5609858 http://www.medworm.com/index.php?rid=5609857&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00561.x CONCLUSIONS:  VCE has a definite impact on the management of refractory sprue. In the remaining patients with established celiac disease, the procedure plays a more limited role. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5609857 Fri, 20 Jan 2012 20:55:33 +0100 5609857 http://www.medworm.com/index.php?rid=5583141&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00573.x © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5583141 Mon, 09 Jan 2012 05:00:00 +0100 5583141 http://www.medworm.com/index.php?rid=5583140&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00574.x Conclusions:  Fenofibrate is effective for improving liver biochemical tests in the patients who have partial response to UDCA monotherapy. It is worthy to explore the efficacy of fenofibrate on histological changes in PBC patients© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5583140 Mon, 09 Jan 2012 05:00:00 +0100 5583140 http://www.medworm.com/index.php?rid=5583139&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00576.x Conclusions:  Once‐daily mesalamine is similarly effective with a comparable safety profile to multiple‐daily regimens for the maintenance treatment of ulcerative colitis, even more effective for inducing remission in active UC.© 2012 The Author. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5583139 Mon, 09 Jan 2012 05:00:00 +0100 5583139 http://www.medworm.com/index.php?rid=5583138&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00575.x CONCLUSION:  The first‐line lansoprazole‐based sequential therapy and concomitant therapy were well‐tolerated and comparable in terms of H. pylori eradication rate.© 2012 The Author. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5583138 Mon, 09 Jan 2012 05:00:00 +0100 5583138 http://www.medworm.com/index.php?rid=5583137&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00577.x Conclusions:  Current guidelines for HCC screening in patients with HBV may lead to delay in diagnosis in non‐cirrhotic patients under age 40. Consideration should be given to modifying current recommendations to advocate entering HBV patients into a cancer‐screening program at a younger age.© 2012 The Author. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5583137 Mon, 09 Jan 2012 05:00:00 +0100 5583137 http://www.medworm.com/index.php?rid=5583136&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00578.x Conclusion  These findings suggest that the promoter methylation may be one of the mechanisms regulating COX‐2 expression in ESCC in response to stimulation of CSE.© 2012 The Author. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5583136 Mon, 09 Jan 2012 05:00:00 +0100 5583136 http://www.medworm.com/index.php?rid=5598648&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00580.x Conclusion: FKN was involved in the progression of SAP and might be a valuable marker for the assessment of SAP.© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5598648 Sun, 01 Jan 2012 05:00:00 +0100 5598648 http://www.medworm.com/index.php?rid=5583135&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2012.00579.x © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5583135 Sun, 01 Jan 2012 05:00:00 +0100 5583135 http://www.medworm.com/index.php?rid=5525852&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00547.x CONCLUSION:  The technique of single‐step EUS‐guided drainage was superior to the technique of a two‐step EUS‐guided drainage technique for PP drainage. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5525852 Thu, 22 Dec 2011 09:24:53 +0100 5525852 http://www.medworm.com/index.php?rid=5525851&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00545.x CONCLUSIONS:  Shortly after a cholecystectomy in Beagle dogs, the CBD pressure increased, SO motilities did not change significantly during the interdigestive phase except with a shortened cycle duration. Its relaxation responded to CCK was weakened with a confused contraction pattern. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5525851 Thu, 22 Dec 2011 09:24:51 +0100 5525851 http://www.medworm.com/index.php?rid=5525850&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00551.x CONCLUSION:  The oncogenesis of rectal cancer may be more complex than that of colon cancer. Some genes could be new biomarkers for distinguishing between these two cancers. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5525850 Thu, 22 Dec 2011 09:24:47 +0100 5525850 http://www.medworm.com/index.php?rid=5525849&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00544.x Extramedullary plasmacytoma (EMP) of the small intestine is an unusual plasma cell neoplasm in this anatomic region with only 61 cases described so far. Clinical suspicion is infrequent owing to its location and nonspecific manifestations such as abdominal pain, obstructive symptoms or even bleeding. Diagnosis is reached through histopathological examination coupled with immunohistochemistry of the endoscopic biopsy or surgical resection specimens. Nevertheless, the differential diagnosis between EMP, lymphoma and other kinds of tumors can sometimes be troublesome. The managements include surgery, radiotherapy or chemotherapy. Generally, the prognosis of EMP is favorable, but occasionally it may relapse, or progress to a plasma cell myeloma. EMP should therefore be followed‐up for a long... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5525849 Thu, 22 Dec 2011 09:24:44 +0100 5525849 http://www.medworm.com/index.php?rid=5525848&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00562.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5525848 Thu, 22 Dec 2011 09:24:40 +0100 5525848 http://www.medworm.com/index.php?rid=5477239&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00569.x This article is intended to succinctly review the recent experimental and clinical findings regarding the involvement of oxidative stress and redox signaling in the pathophysiology of ALD and the development of mechanistically‐based antioxidant modalities to target the oxidative stress and redox signaling mechanisms of ALD. The biochemical and cellular sources of reactive oxygen and nitrogen species (ROS/RNS) and the dysregulated redox signaling pathways associated with alcohol consumption are particularly discussed to provide insight into the molecular basis of hepatic cell dysfunction and destruction as well as tissue remodeling underlying ALD.© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Ren... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5477239 Mon, 05 Dec 2011 05:00:00 +0100 5477239 http://www.medworm.com/index.php?rid=5477238&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00570.x Conclusion:  Blood transfusion during LDLT can be predicted using preoperative variables. Massive RBC transfusion may lead to poor long‐term survival, higher postoperative infection rate and prolonged ICU stay. Platelet transfusion is not a risk factor for long‐term survival.© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5477238 Mon, 05 Dec 2011 05:00:00 +0100 5477238 http://www.medworm.com/index.php?rid=5477237&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00571.x Conclusions:  The incidence of NAFLD in southern China was relatively low in comparison with those in the developed countries. NAFLD cases have a benign prognosis. Variables related to MS are risk factors for NAFLD occurrence and progression.© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5477237 Mon, 05 Dec 2011 05:00:00 +0100 5477237 http://www.medworm.com/index.php?rid=5469583&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00567.x AbstractIn order to prevent Barrett's esophagus (BE)‐related esophageal cancer development in China and facilitate communications of research results among different centers, we propose using standardized diagnostic criteria and taking a conservative approach to diagnose and manage BE patients. BE Patients without dysplasia need to be treated medically. For low‐grade dysplasia, annual endoscopy with biopsies is recommended along with medical therapy. For high‐grade dysplasia and intramucosal carcinoma, an endoscopic or surgical intervention is suggested. All BE patients should be followed up closely.© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5469583 Fri, 02 Dec 2011 05:00:00 +0100 5469583 http://www.medworm.com/index.php?rid=5469582&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00563.x Conclusions:  Octarepeat peptides of prion is responsible for multidrug resistance in gastric cancer cells while the fifth repeat peptide is not.© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5469582 Fri, 02 Dec 2011 05:00:00 +0100 5469582 http://www.medworm.com/index.php?rid=5469581&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00568.x CONCLUSIONS:  BBB permeability increased in SAP rats significantly and time‐dependently, which is correlated with brain MCP‐1 expression. Nifedipine may improve BBB function by inhibition of monocyte chemoattractant protein‐1 expression.© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5469581 Fri, 02 Dec 2011 05:00:00 +0100 5469581 http://www.medworm.com/index.php?rid=5487738&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00565.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5487738 Thu, 01 Dec 2011 05:00:00 +0100 5487738 http://www.medworm.com/index.php?rid=5477236&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00572.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5477236 Thu, 01 Dec 2011 05:00:00 +0100 5477236 http://www.medworm.com/index.php?rid=5469580&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00566.x Conclusion:  Composite SF/G scaffolds are promising candidate matrix for implantable bioartificial livers.© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5469580 Thu, 01 Dec 2011 05:00:00 +0100 5469580 http://www.medworm.com/index.php?rid=5441818&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00538.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5441818 Fri, 25 Nov 2011 09:16:46 +0100 5441818 http://www.medworm.com/index.php?rid=5441817&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00534.x CONCLUSION:  Probiotics are popular among gastroenterologists and surgeons in the UK for the treatment of gastrointestinal disorders. Further evidence to support their routine use, by way of large, well‐designed randomized controlled trials, is necessary. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5441817 Fri, 25 Nov 2011 09:16:44 +0100 5441817 http://www.medworm.com/index.php?rid=5441816&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00540.x CONCLUSIONS  The prevalence of significant hepatic histopathology in CHB patients with serum ALT levels ≤ twice ULN is high. Delayed antiviral treatment can be harmful. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5441816 Fri, 25 Nov 2011 09:16:41 +0100 5441816 http://www.medworm.com/index.php?rid=5441815&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00536.x CONCLUSION:  Laparoscopically assisted resection of SBST is a safe alternative to open resection. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5441815 Fri, 25 Nov 2011 09:16:34 +0100 5441815 http://www.medworm.com/index.php?rid=5441814&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00537.x CONCLUSIONS:  Polymorphism in exon 1 of CTLA‐4 gene at position 49 may act as a candidate of susceptibility locus to PBC. However, larger studies with participants of varying ethnicity and stratified by clinical and laboratory characteristics are needed to validate our findings. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5441814 Fri, 25 Nov 2011 09:16:31 +0100 5441814 http://www.medworm.com/index.php?rid=5441813&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00535.x Barrett's esophagus (BE)‐related esophageal adenocarcinoma (EAC) has shown the fastest rise in incidence in Western countries; however, research data on BE‐related diseases from China are inconclusive. We aimed to review and analyze the published results on these diseases in China. We searched PubMed and Chinese medical literature for key words: BE, EAC, Chinese and China. Relevant research papers along with the study results from our own groups were reviewed and analyzed. Using standardized criteria, columnar‐lined esophagus (CLE) was found in as many as 29% of resection specimens in Chinese patients with proximal gastric cancer. However, BE with intestinal metaplasia was rare, ranging from 0.06% in the general population to <2% in referral patients. Risk factors included advanci... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5441813 Fri, 25 Nov 2011 09:16:29 +0100 5441813 http://www.medworm.com/index.php?rid=5441812&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00541.x To standardize the diagnosis and management of Barrett's esophagus (BE) in China, the Chinese Society of Gastroenterology convened the Second National Conference on BE in June 2011 in Chongqing, China. After intense discussion among experts in this field and an extensive review of the literature, a revised consensus on the diagnosis and management of BE was generated. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5441812 Fri, 25 Nov 2011 09:16:28 +0100 5441812 http://www.medworm.com/index.php?rid=5388379&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00557.x Conclusion:  Low dose of ilaprazole offers a comparable gastric acid inhibition to routine dose omeprazole, which is expected to be further tested in the acid‐associated diseases patients. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388379 Mon, 07 Nov 2011 05:00:00 +0100 5388379 http://www.medworm.com/index.php?rid=5388378&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00558.x CONCLUSION:  This questionnaire based study has illustrated wide variations in EEN protocols used in different areas of the world. The development of consistent protocols may enhance acceptance, efficacy and wider utilisation of this therapy. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388378 Mon, 07 Nov 2011 05:00:00 +0100 5388378 http://www.medworm.com/index.php?rid=5388377&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00559.x ABSTRACTOBJECTIVE:  To develop a rapid high performance liquid chromatography method for determination of tryptophan in gastric juice to help the differentiation of gastric cancer from benign gastric disease.METHODS:  High performance liquid chromatography was performed on restricted access material SHISEIDO CAPCELL PAK MF SCX SG80 column. Phosphate buffered solution (90 mmol/L, pH 3.5)‐acetonitrile (ACN; 80/20, V/V) was chosen as the mobile phase. Separation was done at room temperature using a constant flow rate of 1.0 mL/min. Fluorescence emission signal intensity at 330 nm excited by 288 nm ultra violet light was detected and measured.RESULTS:  Thirty‐eight gastric juice samples from patients with gastric cancer and 48 gastric juice samples of patients with benign gastric dis... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388377 Mon, 07 Nov 2011 05:00:00 +0100 5388377 http://www.medworm.com/index.php?rid=5388376&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00560.x ABSTRACTWhen a patient is hospitalized with acute, severe ulcerative colitis, the primary decision is whether or not to proceed directly to surgery. Absolute indications for immediate colectomy include exsanguinating hemorrhage, perforation and cancer. If medical therapy is undertaken, however, the decision for urgent surgery or non‐operative “salvage” therapy will still be required in the 15–50% of cases in which there is failure to respond within 3‐5 days to a standard regimen of intravenous steroids, antibiotics, decompressive maneuvers, fluid and electrolyte replacement, and other supportive measures. The options for medical salvage therapy are usually cyclosporine or infliximab. There are theoretical and practical arguments on each side; the current GETAID and CONSTRUCT tria... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388376 Mon, 07 Nov 2011 05:00:00 +0100 5388376 http://www.medworm.com/index.php?rid=5388381&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00555.x CONCLUSIONS:  High output and low resistance is the key characters of pulmonary circulation in PHT patients and the abnormal of PVR could be detected when liver function is still compensated. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388381 Thu, 03 Nov 2011 04:00:00 +0100 5388381 http://www.medworm.com/index.php?rid=5388380&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00556.x CONCLUSIONS:  The heterogeneity of the drug transporters may be the reason for the therapeutic sensitivity of 6‐MP in IBD patients. As 6‐MP uptake is a carrier‐mediated and partially sodium‐dependent process, future studies are necessary to evaluate the role of the putative transporters and their correlation with drug sensitivity in patients. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388380 Thu, 03 Nov 2011 04:00:00 +0100 5388380 http://www.medworm.com/index.php?rid=5388383&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00553.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388383 Wed, 02 Nov 2011 04:00:00 +0100 5388383 http://www.medworm.com/index.php?rid=5388382&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00554.x AbstractThe liver X receptors (LXRs) are members of the superfamily of metabolic nuclear receptors that play a central role in regulation of cholesterol absorption, efflux, transport and excretion and many other processes correlating with lipid metabolism. LXRs can also regulate the inflammatory process in vitro and in vivo. The accumulating evidences demonstrate that LXRs involve in the metabolic and inflammatory process in human diseases. Nonalcoholic fatty liver disease (NAFLD) is classically associated with lipid metabolic disorders and inflammatory response, especially in nonalcoholic steatohepatitis (NASH) phase. LXRs’ effects on cholesterol metabolism and anti‐inflammation process make them attractive as potential target for the treatment of NAFLD. Since the ability to synthesiz... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388382 Wed, 02 Nov 2011 04:00:00 +0100 5388382 http://www.medworm.com/index.php?rid=5362352&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00549.x Conclusion:  Gastric biopsy specimens stored within the gel of an RUT for 30 days can be used to for molecular testing confirm the diagnosis of H. pylori infection and test for clarithromycin susceptibility. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362352 Mon, 31 Oct 2011 04:00:00 +0100 5362352 http://www.medworm.com/index.php?rid=5362351&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00551.x CONCLUSIONS:  The oncogenesis of rectal cancer may be more complex than that of colon cancer. Some genes could be new biomarkers for distinguishing between these two cancers. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362351 Mon, 31 Oct 2011 04:00:00 +0100 5362351 http://www.medworm.com/index.php?rid=5362357&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00545.x Conclusions:  Shortly after cholecystectomy in Beagle dogs, the CBD pressure increased, SO motilities didn't change significantly during the interdigestive phase except a shortened cycle duration. Its relaxation responded to CCK was weakened with a confused contraction pattern. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362357 Fri, 28 Oct 2011 04:00:00 +0100 5362357 http://www.medworm.com/index.php?rid=5362356&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00546.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362356 Fri, 28 Oct 2011 04:00:00 +0100 5362356 http://www.medworm.com/index.php?rid=5362355&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00547.x Conclusion:  The technique of single‐step EUS‐guided PP drainage was superior to the technique of two step EUS‐guided drainage technique PP drainage. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362355 Fri, 28 Oct 2011 04:00:00 +0100 5362355 http://www.medworm.com/index.php?rid=5362354&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00548.x Conclusions:  Patients with synchronous upper GI cancers are mainly male and present with different anatomic distribution, endoscopic features and carry poor prognosis as compared with single primary cancer. This case series describe the clinical profiles and emphasize the necessity of a thorough examination for additional cancers before treatment of upper GI cancer. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362354 Fri, 28 Oct 2011 04:00:00 +0100 5362354 http://www.medworm.com/index.php?rid=5362353&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00550.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362353 Fri, 28 Oct 2011 04:00:00 +0100 5362353 http://www.medworm.com/index.php?rid=5388375&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00561.x CONCLUSIONS:  VCE shows a definite impact on the management of refractory sprue. In the remaining patients with established celiac disease, the procedure plays a more limited role. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5388375 Sat, 01 Oct 2011 04:00:00 +0100 5388375 http://www.medworm.com/index.php?rid=5362350&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00552.x CONCLUSIONS:  The detection of blood pyrrole‐protein adducts using UPLC‐MS approach is a specific, reliable, unambiguous and confirmatory causation test for HSOS induced by PAs, and should be used together with the conventional HSOS clinical diagnostic criteria for the definitive diagnosis of PA‐induced HSOS. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5362350 Sat, 01 Oct 2011 04:00:00 +0100 5362350 http://www.medworm.com/index.php?rid=5336877&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00544.x AbstractExtramedullary plasmacytoma (EMP) of the small bowel is an unusual plasma cell neoplasm (PCN) in this anatomic region with only 61 cases described so far. Clinical suspicion is infrequent owing to its location and nonspecific manifestations of abdominal pain, obstructive symptoms or even bleeding. Diagnosis is reached through histopathological examination coupled with immunohistochemistry study of the endoscopic biopsy or surgical resection specimens. Nevertheless, the differential diagnosis between EMP, lymphomas and other kinds of tumors can sometimes be troublesome. Its management include surgery, radiotherapy or chemotherapy. Generally, the prognosis of EMP is favourable, but occasionally it may relapse, as more really progresses to plasmacytic myeloma (PCM). So, EMP should be ... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5336877 Sat, 01 Oct 2011 04:00:00 +0100 5336877 http://www.medworm.com/index.php?rid=5261528&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00530.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261528 Thu, 29 Sep 2011 08:21:47 +0100 5261528 http://www.medworm.com/index.php?rid=5261527&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00517.x CONCLUSION:  High b value DW imaging in combination with ADC quantification at a 3‐T MR system is useful in differentiating between pancreatic carcinoma and MFCP. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261527 Thu, 29 Sep 2011 08:21:43 +0100 5261527 http://www.medworm.com/index.php?rid=5261526&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00527.x CONCLUSION:  ICOS can enhance the cytotoxic effect of CIK cells against cholangiocarcinoma both in vitro and in vivo. This effect is mediated by ICOS‐augmented cytokine secretion and cell proliferation, and in part through ICOS‐ICOSL interaction. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261526 Thu, 29 Sep 2011 08:21:41 +0100 5261526 http://www.medworm.com/index.php?rid=5261525&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00522.x CONCLUSION:  Nearly all patients experienced relief from their lupus‐like symptoms with certolizumab and 2 out of 4 patients reversed their ANA positivity. While future investigation is warranted, patients who have lupus‐like reactions from infliximab or adalimumab may benefit from switching to certolizumab. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261525 Thu, 29 Sep 2011 08:21:38 +0100 5261525 http://www.medworm.com/index.php?rid=5261524&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00519.x CONCLUSION:  An isolated high AET is uncommon in patients with cough or LPS. Combined MII‐pH improves the diagnostic yield in patients with atypical GERD manifestations. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261524 Thu, 29 Sep 2011 08:21:30 +0100 5261524 http://www.medworm.com/index.php?rid=5261523&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00469.x The metabolic syndrome is a common complex entity that has emerged as a worldwide epidemic and major public health care concern with a prevalence of approximately 25% in the United States. There have been a number of different definitions of the metabolic syndrome but all center around the metabolic abnormalities of central obesity, hypertension, decreased high‐density lipoproteins and elevated triglycerides with insulin resistance as the uniting physiologic factor. The importance of the metabolic syndrome is not just related to its high prevalence rate but also because it predicts the development of diabetes and cardiovascular disease. Nonalcoholic fatty liver disease is now recognized to be the hepatic component of the metabolic syndrome, which along with its individual components – ... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261523 Thu, 29 Sep 2011 08:21:28 +0100 5261523 http://www.medworm.com/index.php?rid=5261522&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00525.x Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease which is characterized by the recurrent intestinal inflammation and overactive immune responses. The signaling pathways of p38 mitogen‐activated protein kinase (MAPK) play an important role in bowel inflammation. The inhibition of p38 MAPK can effectively suppress the expression of inflammatory mediators. However, due to the obvious preclinical and clinical side effects, p38 inhibitors are unacceptable in safety profiles and cannot be applied in the treatment of IBD. MAPK‐activated protein kinase 2 (MK2), as the direct substrate of p38α and p38β, is a multifunctional signaling protein in the progression of inflammation and several lines of evidence demonstrate that the inhibition of MK2 may produce the s... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261522 Thu, 29 Sep 2011 08:21:26 +0100 5261522 http://www.medworm.com/index.php?rid=5261521&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00529.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261521 Thu, 29 Sep 2011 08:21:25 +0100 5261521 http://www.medworm.com/index.php?rid=5261520&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00528.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5261520 Thu, 29 Sep 2011 08:21:23 +0100 5261520 http://www.medworm.com/index.php?rid=5226966&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00532.x Conclusions:  Atrophy and intestinal metaplasia are rare, but activity and chronic inflammation are severe at the antrum, angulus, and corpus. Pangastritis is the commonest type of gastritis. Lymphoid follicles affect all mucosal layers up to the upper corpus, whereas endoscopic protrusion is found only at the angulus. No correlation with pathological features has been found between N and G types. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226966 Tue, 13 Sep 2011 04:00:00 +0100 5226966 http://www.medworm.com/index.php?rid=5226965&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00533.x CONCLUSION:  In our study, both polymorphisms in the DLG5 gene were found to be associated to CD patients in Malaysia. Therefore, these loci can be potentially used as susceptibility markers in the local Malaysian population. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226965 Tue, 13 Sep 2011 04:00:00 +0100 5226965 http://www.medworm.com/index.php?rid=5226964&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00534.x Conclusions:  Probiotics are popular amongst gastroenterologists and surgeons for the treatment of gastrointestinal disease. Further evidence to support their routine use, by way of large, well‐designed randomised controlled trials, is necessary. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226964 Tue, 13 Sep 2011 04:00:00 +0100 5226964 http://www.medworm.com/index.php?rid=5226963&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00535.x AbstractAt present, esophageal adenocarcinoma (EAC) in the United States has the fastest rising incidence among cancers of the lung, breast, prostate, colon, rectum, and malignant melanoma1. This cancer has outnumbered esophageal squamous cell carcinomas in the United States2 and several European countries3. A growing body of evidence indicates that Barrett esophagus (BE) may be the only proven risk factor for EAC. In contrast, the published studies in the English medical literature on BE‐related diseases in China have been scarce and inconclusive. Most recently, however, several epidemiologic, endoscopic, and clinicopathological studies showed intriguing results. In this review, we examined the data published recently to provide readers with the updated information on BE‐related disea... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226963 Tue, 13 Sep 2011 04:00:00 +0100 5226963 http://www.medworm.com/index.php?rid=5226962&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00536.x CONCLUSION:  Laparoscopically‐assisted resection of SBSTs is a safe and cost‐effective alternative to open resection. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226962 Tue, 13 Sep 2011 04:00:00 +0100 5226962 http://www.medworm.com/index.php?rid=5226961&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00537.x CONCLUSIONS:  Polymorphism in exon 1 of the CTLA‐4 gene at position 49 may act as a candidate susceptibility locus to PBC. However, larger studies with mixed ethnicity subjects and stratified by clinical and laboratory characteristics are needed to validate our findings. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226961 Tue, 13 Sep 2011 04:00:00 +0100 5226961 http://www.medworm.com/index.php?rid=5226960&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00538.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226960 Tue, 13 Sep 2011 04:00:00 +0100 5226960 http://www.medworm.com/index.php?rid=5226959&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00539.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226959 Tue, 13 Sep 2011 04:00:00 +0100 5226959 http://www.medworm.com/index.php?rid=5226958&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00540.x Conclusions:  The prevalence of significant hepatic histopathology in CHB patients with serum ALT levels ≤ 2 × ULN is high. Delayed antiviral treatment can be deteriorative. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226958 Tue, 13 Sep 2011 04:00:00 +0100 5226958 http://www.medworm.com/index.php?rid=5226957&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00541.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226957 Tue, 13 Sep 2011 04:00:00 +0100 5226957 http://www.medworm.com/index.php?rid=5251396&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00543.x Conclusion:  Epiploic appendagitis is the inflammatory response of an appendage to infarction or spontanoues venous thrombosis. CT scan provided a definite diagnosis of epiploic appendagitis, thus unnecessary surgical intervention andantibiotics can be avoided. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5251396 Mon, 01 Aug 2011 04:00:00 +0100 5251396 http://www.medworm.com/index.php?rid=5226956&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00542.x Conclusion:  ImmuKnow assay monitoring has a potential to identify the patients at risk of developing invasive fungal infections after liver transplantation, which may provide a feasible measure on optimizing liver recipients’ immune cellular function after transplantation. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5226956 Mon, 01 Aug 2011 04:00:00 +0100 5226956 http://www.medworm.com/index.php?rid=5064202&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00514.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5064202 Tue, 26 Jul 2011 18:45:08 +0100 5064202 http://www.medworm.com/index.php?rid=5064201&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00510.x CONCLUSIONS:  These results showed that the mean concentration of IL‐27 in H. pylori‐infected peptic ulcer (PU) patients was higher than in AS carriers and the healthy control group. The serum concentrations of IL‐27 were not affected by the CagA factor. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5064201 Tue, 26 Jul 2011 18:45:02 +0100 5064201 http://www.medworm.com/index.php?rid=5064200&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00508.x CONCLUSION:  Proliferative activity after fundoplication increased during long‐term follow up in the distal esophagus despite a normal fundic wrap and objective healing of GERD. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5064200 Tue, 26 Jul 2011 18:44:56 +0100 5064200 http://www.medworm.com/index.php?rid=5064199&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00511.x One of typical examples of liver‐gut cross talk is the interaction and impact of inflammatory bowel disease (IBD) and hepatobiliary (HB) abnormalities on each other's disease course. There are several layers of association between IBD and HB diseases: (i) HB diseases and IBD share pathogenetic mechanisms; (ii) HB diseases parallel structural and pathophysiological changes seen with IBD; and (iii) hepatic toxicity is associated with medical therapy for IBD. Interdisciplinary approach, involving gastroenterologists, hepatologists and, in advanced cases, general, colorectal, and liver transplant surgeons, is advocated. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5064199 Tue, 26 Jul 2011 18:44:54 +0100 5064199 http://www.medworm.com/index.php?rid=5021600&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00520.x CONCLUSIONS:  Our data showed a significant increase in diagnostic yield with increasing degree of anemia. Relative difference in hemoglobin rather than absolute values may be a better predictor. The ability of VCE to guide further intervention reached significance in severely bleeding patients. The hypothesis that use of VCE prior to EGD or colonoscopy in the severely bleeding group deserves to be evaluated. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021600 Sun, 10 Jul 2011 23:00:00 +0100 5021600 http://www.medworm.com/index.php?rid=5021599&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00521.x CONCLUSION:  The combined evaluation of tissue DCP expression and serum DCP level is more useful than either factor alone in predicting prognosis for patients with HCC and liver cirrhosis. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021599 Sun, 10 Jul 2011 23:00:00 +0100 5021599 http://www.medworm.com/index.php?rid=5021598&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00522.x Conclusion:  Nearly all patients experienced relief lupus like symptoms with certolizumab and 2/4 patients reversed ANA positivity. While future investigation is warranted, patients who have lupus like reactions from infliximab or adalimumab may benefit from switching to certolizumab (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021598 Sun, 10 Jul 2011 23:00:00 +0100 5021598 http://www.medworm.com/index.php?rid=5021597&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00523.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021597 Sun, 10 Jul 2011 23:00:00 +0100 5021597 http://www.medworm.com/index.php?rid=5021596&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00524.x Conclusions: Although MEI does not generally accelerate colonoscope advancement, it significantly reduces the force and the duration of abdominal compression by assistant personnel, thus minimising patient discomfort and decreasing the need for additional staff workforce. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021596 Sun, 10 Jul 2011 23:00:00 +0100 5021596 http://www.medworm.com/index.php?rid=5021595&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00525.x ABSTRACTInflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease which are characterized by the recurrent intestinal inflammation and overactive immune responses. The signaling pathways of p38 mitogen‐activated protein kinase (MAPK) play an important role in the bowel inflammation. Inhibition of p38MAPK can effectively suppress the expression of inflammatory mediators. However, due to the obvious preclinical and clinical side effects, the p38 inhibitors are unacceptable in safety profiles and can not be applied in the treatment of IBD. MAPK‐activated protein kinase 2 (MK2), as the direct substrate of p38α and p38β, is a multi‐functional signaling protein in the progression of inflammation, and several lines of evidence demonstrated that inhibition of MK2 may... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021595 Sun, 10 Jul 2011 23:00:00 +0100 5021595 http://www.medworm.com/index.php?rid=5021594&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00526.x Conclusion:  The economic burden of FBDs seems to be moderately high in Iran and it imposes a relatively heavy financial burden on the Iranian national health system because of its high prevalence and its impact on quality of life, productivity and waste of resources. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021594 Sun, 10 Jul 2011 23:00:00 +0100 5021594 http://www.medworm.com/index.php?rid=5021593&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00527.x Conclusions:  ICOS can enhance the cytotoxic effect of CIK cells against cholangiocarcinoma both in vitro and in vivo. This effect is mediated by ICOS‐augmented cytokine secretion and cell proliferation, and in part through ICOS‐ICOSL interaction. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021593 Sun, 10 Jul 2011 23:00:00 +0100 5021593 http://www.medworm.com/index.php?rid=4896247&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00511.x ABSTRACTOne of typical examples liver‐gut cross talk is the impact of inflammatory bowel disease (IBD) and hepatobiliary (HB) abnormalities on each other's disease course. There are several layers of association between IBD and HB diseases: 1) HB diseases and IBD share pathogenetic mechanisms; 2) HB diseases parallel structural and pathophysiological changes seen with IBD; 3) Hepatic toxicity is associated with medical therapy for IBD. Interdisciplinary approach, involving gastroenterologists, hepatologists, and in advanced cases, general, colorectal, and liver transplant surgeons, is advocated. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4896247 Thu, 02 Jun 2011 23:00:00 +0100 4896247 http://www.medworm.com/index.php?rid=4896246&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00512.x Conclusions: Buried intestinal metaplasia mainly with incomplete type is the major predominant type of BE. The degree of inflammation in gastric antrum and esophagus can differentiate BE from CIM to some extent. CK‐7 immunohistochemical staining can help identify BE and CIM but Muc‐1 cannot. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4896246 Thu, 02 Jun 2011 23:00:00 +0100 4896246 http://www.medworm.com/index.php?rid=4896245&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00513.x Conclusions: PO stimulates bile fluid secretion and thus has a choleretic effect. PO might play a role in up‐regulating CYP7A1 and FXR mRNA levels, suggesting that the molecular mechanisms are related to gene expression involving in bile acid synthesis. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4896245 Thu, 02 Jun 2011 23:00:00 +0100 4896245 http://www.medworm.com/index.php?rid=4896244&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00514.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4896244 Thu, 02 Jun 2011 23:00:00 +0100 4896244 http://www.medworm.com/index.php?rid=5053550&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00531.x CONCLUSIONS:  2000s witnessed a significant increase in detection rate of A‐CRA, but CRC did not increase at a similar speed. Our results indicated that early detection and removal of colorectal adenoma in symptomatic patients might decrease the incidence of CRC. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5053550 Tue, 31 May 2011 23:00:00 +0100 5053550 http://www.medworm.com/index.php?rid=5021592&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00528.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=5021592 Tue, 31 May 2011 23:00:00 +0100 5021592 http://www.medworm.com/index.php?rid=4999811&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00519.x Conclusion:  An isolated high AET is uncommon in patients with cough or LPS. Combined MII‐pH improves the diagnostic yield in patients with atypical GERD manifestations. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4999811 Tue, 31 May 2011 23:00:00 +0100 4999811 http://www.medworm.com/index.php?rid=4955076&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00516.x AbstractEndoscopic submucosal dissection (ESD) is a safe and effective alternative to surgery for large non‐polypoid colonic lesions and early colorectal carcinoma. In this article, we discuss the development, efficacy and safety of ESD. As the incidence of colorectal cancer is rapidly increasing in Asia, we advocate standardization of ESD program, including patient selection, hardware prerequisites, and training of operators. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4955076 Tue, 31 May 2011 23:00:00 +0100 4955076 http://www.medworm.com/index.php?rid=4938469&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00518.x CONCLUSIONS:  EN (PEN, lactobacillus, and glutamine) is proved to be an effective therapy for treating DDS‐induced colitis. EN could alleviate the damage, promote the repair of colonic epithelial cells, and inhibit bacterial translocation. Lactobacillus and glutamine also could increase the lactobacilli in colon. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4938469 Tue, 31 May 2011 23:00:00 +0100 4938469 http://www.medworm.com/index.php?rid=4914494&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00517.x Conclusions:  Pancreatic carcinoma could be well demonstrated in DW imaging with b value of 1000 s/mm2. DWI in combination with ADC quantification was useful in differentiation between pancreatic carcinoma and mass‐forming chronic pancreatitis. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4914494 Tue, 31 May 2011 23:00:00 +0100 4914494 http://www.medworm.com/index.php?rid=4896243&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00515.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4896243 Tue, 31 May 2011 23:00:00 +0100 4896243 http://www.medworm.com/index.php?rid=4873674&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00500.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4873674 Sat, 28 May 2011 18:06:38 +0100 4873674 http://www.medworm.com/index.php?rid=4873673&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00499.x CONCLUSIONS:  Betadine irrigation of the GI tract is effective and feasible for preventing infection during the NOTES procedure. Further studies are needed for assessing the effectiveness and safety of betadine irrigation in the clinical application of NOTES. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4873673 Sat, 28 May 2011 18:06:37 +0100 4873673 http://www.medworm.com/index.php?rid=4873672&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00490.x CONCLUSIONS:  Low‐dose liver CTPI obtained similar perfusion parameters result to that of the conventional‐dose, whereas the radiation dosage was reduced by 2/3. Low‐dose liver CTPI can reflect the hemodynamic change of HCC. Low‐dose liver CTPI has potential clinical value for diagnosis and differential diagnosis of liver diseases. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4873672 Sat, 28 May 2011 18:06:36 +0100 4873672 http://www.medworm.com/index.php?rid=4873671&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00496.x CONCLUSION:  The newly developed assay may be the method of choice when detection of genotypes present at low levels in mixed‐genotype infections due to its higher level of sensitivity. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4873671 Sat, 28 May 2011 18:06:35 +0100 4873671 http://www.medworm.com/index.php?rid=4873670&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00494.x CONCLUSION:  EGCG combined with folic acid has an obvious chemopreventive effect on gastrointestinal carcinogenesis induced by MNNG in rats. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4873670 Sat, 28 May 2011 18:06:33 +0100 4873670 http://www.medworm.com/index.php?rid=4873669&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00502.x CONCLUSIONS:  Few LPR occurred in healthy Chinese volunteers and they were rarely acid when they reached the larynx. LPR was mostly associated with liquid reflux. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4873669 Sat, 28 May 2011 18:06:33 +0100 4873669 http://www.medworm.com/index.php?rid=4873668&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00491.x Cisapride, the prototype serotonergic agent, evolved from a body of research that defined the key roles of serotonergic receptors in gastrointestinal motor and sensory function. Impressed by its in vitro properties and encouraged by clinical trial data, cisapride became the drug of choice for the treatment of a wide range of motility disorders and clinicians appeared impressed by its efficacy and comfortable with its side‐effect profile. Once serious cardiac events began to be reported in association with cisapride therapy, dark clouds rapidly gathered and soon enveloped the drug, leading to its widespread withdrawal from markets. What lessons can we learn from the story of cisapride? How can its brief but spectacular rise and equally sensational demise inform the development of new drug... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4873668 Sat, 28 May 2011 18:06:31 +0100 4873668 http://www.medworm.com/index.php?rid=4806748&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00505.x CONCLUSIONS: There were a decrease of CD4+FOXP3+ Treg cells in peripheral blood and an accumulation of Treg cells in inflamed mucosa. These data suggested that the suppressive function of Treg cells may be partially inhibited and this could be an important factor causing the recurrence of disease, especially in UC. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4806748 Mon, 09 May 2011 23:00:00 +0100 4806748 http://www.medworm.com/index.php?rid=4806747&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00506.x CONCLUSION: HIF‐1, Ang‐2, Dll4 and Notch1 might participate in the formation of GIVM. Thalidomide is an effective and safe treatment agent for GIVM and its associated bleeding. The reduction degree of Ang‐2 after 4‐month treatment of thalidomide may offer values for evaluating its prognosis and efficacy. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4806747 Mon, 09 May 2011 23:00:00 +0100 4806747 http://www.medworm.com/index.php?rid=4806746&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00507.x Conclusions: P1FI of the intrinsic fluorescence at 288 nm is significantly higher in patients with gastric cancers compared with individuals with benign lesions. As a clinical indicator of gastric cancer, its sensitivity, specificity, and accuracy were high. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4806746 Mon, 09 May 2011 23:00:00 +0100 4806746 http://www.medworm.com/index.php?rid=4806745&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00508.x CONCLUSION: Proliferative activity after fundoplication increased during long‐term follow‐up in the distal esophagus despite a normal fundic wrap and objective healing of GERD. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4806745 Mon, 09 May 2011 23:00:00 +0100 4806745 http://www.medworm.com/index.php?rid=4832433&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00510.x Conclusion: These results showed that the mean concentrations of IL‐27 in H. pylori‐infected peptic ulcer (PU) patients was higher than AS carriers and healthy control group. The serum concentrations of IL‐27 were not affected by CagA factor. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4832433 Thu, 31 Mar 2011 23:00:00 +0100 4832433 http://www.medworm.com/index.php?rid=4806744&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00509.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4806744 Thu, 31 Mar 2011 23:00:00 +0100 4806744 http://www.medworm.com/index.php?rid=4783234&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00504.x Conclusions: Patients with colorectal cancer and adenoma demonstrated remarkally lower adiponectin values compared with controls, yet with significant heterogeneity among studies. A negative dose–response relationship between levels of adiponectin and the risk of colorectal neoplasm was observed in men. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4783234 Thu, 31 Mar 2011 23:00:00 +0100 4783234 http://www.medworm.com/index.php?rid=4632667&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00503.x Conclusions: Although performing biopsy of terminal ileum despite a macroscopically normal appearance may offer some additional benefit to the diagnosis of chronic non‐bloody diarrhea, prospective trials are needed for assessing the diagnostic value of terminal ileum biopsy in patients with chronic diarrhea (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4632667 Fri, 25 Mar 2011 17:35:39 +0100 4632667 http://www.medworm.com/index.php?rid=4632669&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00494.x Conclusion: EGCG combined with folic acid have obvious chemopreventive effect on gastrointestinal carcinogenesis induced by MNNG in rats. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4632669 Fri, 25 Mar 2011 00:00:00 +0100 4632669 http://www.medworm.com/index.php?rid=4632668&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00502.x Conclusions: Few LPRs occurred in Chinese healthy volunteers and rarely were acid while reaching larynx. The presence of LPR was mostly associated with liquid reflux. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4632668 Fri, 25 Mar 2011 00:00:00 +0100 4632668 http://www.medworm.com/index.php?rid=4617240&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00501.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617240 Tue, 22 Mar 2011 17:34:03 +0100 4617240 http://www.medworm.com/index.php?rid=4617249&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00491.x AbstractCisapride, the prototype serotonergic agent, evolved from a body of research which defined the key roles of serotonergic receptors in gastrointestinal motor and sensory function. Impressed by its in vitro properties and encouraged by clinical trial data, cisapride became the drug of choice for the treatment of a wide range of motility disorders and clinicians appeared impressed by its efficacy and comfortable with its side effect profile. Once serious cardiac events began to be reported in association with cisapride therapy, dark clouds rapidly gathered and soon enveloped the drug leading to its widespread withdrawal from markets. What lessons can we learn from the story of cisapride? How can its brief but spectacular rise and equally sensational demise inform the development of ne... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617249 Tue, 22 Mar 2011 00:00:00 +0100 4617249 http://www.medworm.com/index.php?rid=4617248&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00492.x AbstractWhile dietary habits or nutritional intakes continue to rank as a significant factor influencing cancer incidence, there had been considerable scientific uncertainties about who will be benefited, but who will not be benefited by nutrition. This might be due to inadequate knowledge about an individual's genetic background, cumulative effect of nutrients on genetic expression profiles, ambiguous clinical difference between beneficiary and non‐beneficiary, and the lack of information about active protein induction. During the past 200years of nutrition research, we have experienced the revolutionary advancement in either chemical revolution or genomic revolution. According to the high expectation for tailored medicine, nutrigenomic approach harboring tremendous potential to change ... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617248 Tue, 22 Mar 2011 00:00:00 +0100 4617248 http://www.medworm.com/index.php?rid=4617247&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00493.x CONCLUSION: Adalimumab is effective and safe in Crohn's disease. However, larger number of patients is still required for better assessing the safety profile of adalimumab. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617247 Tue, 22 Mar 2011 00:00:00 +0100 4617247 http://www.medworm.com/index.php?rid=4617246&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00495.x Conclusion: There might be a traditional serrated pathway of sporadic colorectal carcinogenesis which is different from the conventional adenoma‐carcinoma carcinogenesis pathway in colorectum. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617246 Tue, 22 Mar 2011 00:00:00 +0100 4617246 http://www.medworm.com/index.php?rid=4617245&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00496.x CONCLUSION: The newly developed assay may be the method of choice when detection of genotypes present at low levels in mixed‐genotype infections due to its higher level of sensitivity. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617245 Tue, 22 Mar 2011 00:00:00 +0100 4617245 http://www.medworm.com/index.php?rid=4617244&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00497.x Conclusion: Low‐dose liver CTPI achieved the result of perfusion parameters similar to that of the conventional‐dose, whereas the radiation dosage was reduced by 2/3. Low‐dose liver CTPI can reflect the hemodynamic changes of HCC, and has potential clinical value in diagnosis and differential diagnosis of liver diseases. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617244 Tue, 22 Mar 2011 00:00:00 +0100 4617244 http://www.medworm.com/index.php?rid=4617243&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00498.x Conclusions: Aspects of AIP‐associated pancreatic diabetes were clarified. AIP‐associated DM must be controlled by full assessment of pancreatic endocrine and exocrine function. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617243 Tue, 22 Mar 2011 00:00:00 +0100 4617243 http://www.medworm.com/index.php?rid=4617242&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00499.x CONCLUSION: Betadine irrigation of G‐I tract is effective and feasible for preventing infection during the procedure of NOTES. Further studies are needed for assessing the effectiveness and safety of betadine irrigation in the clinical application of NOTES. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617242 Tue, 22 Mar 2011 00:00:00 +0100 4617242 http://www.medworm.com/index.php?rid=4617241&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00500.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4617241 Tue, 22 Mar 2011 00:00:00 +0100 4617241 http://www.medworm.com/index.php?rid=4596141&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00479.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4596141 Wed, 16 Mar 2011 17:18:21 +0100 4596141 http://www.medworm.com/index.php?rid=4596140&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00464.x CONCLUSION:  MICA, MICB and NKG2D were upregulated in the colonic mucosa of UC and were associated with activating NK cells with promoted NKG2D and IFN‐γ production. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4596140 Wed, 16 Mar 2011 17:18:17 +0100 4596140 http://www.medworm.com/index.php?rid=4596139&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00490.x Conclusion: Low‐dose liver CTPI obtained similar perfusion parameters result to that of the conventional‐dose, whereas the radiation dosage was reduced by 2/3. Low‐dose liver CTPI can reflect the hemodynamic change of HCC. Low‐dose liver CTPI has potential clinical value for diagnosis and differential diagnosis of liver diseases. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4596139 Wed, 16 Mar 2011 17:18:14 +0100 4596139 http://www.medworm.com/index.php?rid=4415734&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00472.x This article details the current terminology for various forms of FLD, highlights the key histological features and reviews recent advances in the field. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4415734 Mon, 31 Jan 2011 16:09:19 +0100 4415734 http://www.medworm.com/index.php?rid=4415733&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00467.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4415733 Mon, 31 Jan 2011 16:09:18 +0100 4415733 http://www.medworm.com/index.php?rid=4412509&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00482.x CONCLUSION: HSP27 phosphorylation with resultant decrease in HSP27 level was one of mechanisms of indomethacin‐induced cytotoxicity, of which post‐translational modifications were prevented with revaprazan administration in the presence of indomethacin. Therefore, acid pump antagonist could be a choice of the prevention for NSAID‐induced gastropathy backed up with distinctive cytoprotective action beyond acid suppressor. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412509 Fri, 28 Jan 2011 00:00:00 +0100 4412509 http://www.medworm.com/index.php?rid=4412508&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00483.x CONCLUSION: This study demonstrated a probable association of the Bsm I polymorphism of the VDR gene with ulcerative colitis susceptibility in Han Chinese. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412508 Fri, 28 Jan 2011 00:00:00 +0100 4412508 http://www.medworm.com/index.php?rid=4412507&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00484.x CONCLUSION: The risk factors associated with disabling Crohn's disease which entails the requirement of top‐down therapy in Chinese patients are steroids requirement for treating acute exacerbation, presence of perianal disease at diagnosis. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412507 Fri, 28 Jan 2011 00:00:00 +0100 4412507 http://www.medworm.com/index.php?rid=4412506&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00485.x Conclusions: Treatment with three infusions of IFX at a dose of 5 mg/kg was effective for induction of remission for active CD patients who failed to respond to conventional therapies. Study of long‐term efficacy and safety of IFX therapy is warranted for further investigations. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412506 Fri, 28 Jan 2011 00:00:00 +0100 4412506 http://www.medworm.com/index.php?rid=4412505&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00486.x CONCLUSIONS: TLR2 and TLR3 may be involved in the pathogenesis of CSHB, and TLR3 may influence the prognosis of CSHB. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412505 Fri, 28 Jan 2011 00:00:00 +0100 4412505 http://www.medworm.com/index.php?rid=4412504&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00487.x CONCLUSION: The prevalence of MS varied depending on the diagnostic criteria used. NAFLD was strongly associated with the MS, although it remains unknown whether NAFLD is a cause or effect of MS. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412504 Fri, 28 Jan 2011 00:00:00 +0100 4412504 http://www.medworm.com/index.php?rid=4412503&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00488.x CONCLUSIONS: These findings indicate the potential clinical significance for serum DJ‐1 level to be used for the diagnosis and prognosis prediction of patients with PC. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412503 Fri, 28 Jan 2011 00:00:00 +0100 4412503 http://www.medworm.com/index.php?rid=4401275&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00478.x Conclusion:Ufd1 plays a key role in HCPT resistance of SW1116/HCPT, RNAi of Ufd1 can sensitize SW1116/HCPT to the cytotoxic effect of HCPT via strengthening the activation of caspase‐3 pathway and disturbing endoplasmic reticulum functions. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4401275 Wed, 26 Jan 2011 00:00:00 +0100 4401275 http://www.medworm.com/index.php?rid=4401274&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00479.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4401274 Wed, 26 Jan 2011 00:00:00 +0100 4401274 http://www.medworm.com/index.php?rid=4401273&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00480.x ABSTRACTALDH2‐and ADH gene polymorphisms associating with enhanced acetaldehyde exposure and markedly increased cancer risk in alcohol drinkers provide undisputable evidence for acetaldehyde being a local carcinogen not only in esophageal but also in gastric cancer. Accordingly, acetaldehyde associated with alcoholic beverages has recently been classified as Group 1 carcinogen to humans. Microbes are responsible for the bulk of acetaldehyde production from ethanol both in saliva, H. pylori infected and achlorhydric stomach. Acetaldehyde is the most abundant carcinogen in tobacco smoke, and it readily dissolves into saliva during smoking. Many food stuffs and “non‐alcoholic” beverages are important but unrecognized sources of local acetaldehyde exposure. The cumulative cancer risk a... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4401273 Wed, 26 Jan 2011 00:00:00 +0100 4401273 http://www.medworm.com/index.php?rid=4412502&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00489.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4412502 Wed, 01 Dec 2010 00:00:00 +0100 4412502 http://www.medworm.com/index.php?rid=4401272&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2011.00481.x AbstractStudies on sphingolipid have become one of the most rapidly progressed fields in the last 2 decades. These highly diverse lipids have been known to have multiple physiological functions and clinical implications in several diseases including tumorigenesis, inflammation, atherosclerosis, and neural degenerative diseases. Differing from other organs, sphingolipids in the intestinal tract are not only present as lipid constituents in the cells, but also as dietary compositions for digestion in the lumen. The present review is to focus on the presence of sphingolipids and their catalytic enzymes in the gut, the metabolism and the signaling effects of the metabolites, and their impacts on barrier functions, cholesterol absorption, inflammatory diseases and tumor development in the gut. ... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4401272 Wed, 01 Dec 2010 00:00:00 +0100 4401272 http://www.medworm.com/index.php?rid=4192686&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00461.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4192686 Wed, 24 Nov 2010 04:56:44 +0100 4192686 http://www.medworm.com/index.php?rid=4192685&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00462.x CONCLUSION:  CTLA‐4 expressions were aberrant in UC patients compared with the healthy controls. CTLA‐4 ‐1661A/G polymorphism had no significant impact on CTLA‐4 expression and transcription in the peripheral CD4 T cells of UC patients. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4192685 Wed, 24 Nov 2010 04:56:43 +0100 4192685 http://www.medworm.com/index.php?rid=4192684&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00460.x CONCLUSION:  A cap‐fitted colonoscopy can shorten the examination time for inexperienced endoscopists. It can also reduce the patients' discomfort during the procedure. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4192684 Wed, 24 Nov 2010 04:56:40 +0100 4192684 http://www.medworm.com/index.php?rid=4192683&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00463.x CONCLUSION:  Monitoring cytochrome P450 1A2 (CYP450 1A2)‐mediated phenacetin metabolism is a simple and efficient method for evaluating human LRF. This method would warrant further validation in a large cohort clinical study. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4192683 Wed, 24 Nov 2010 04:56:40 +0100 4192683 http://www.medworm.com/index.php?rid=4192682&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00465.x CONCLUSION:  MELD score ≤ 18 combined with PA ≥ 70 mg/L could predict the 6‐month and 1‐year prognosis of patients with decompensated liver cirrhosis, and was superior to that of MELD score alone. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4192682 Wed, 24 Nov 2010 04:56:39 +0100 4192682 http://www.medworm.com/index.php?rid=4192681&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00459.x CONCLUSION:  The expression of XRCC1 is downregulated in gastric carcinogenesis, and promoter hypermethylation may be one of the mechanisms contributing to its downregulation. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4192681 Wed, 24 Nov 2010 04:56:39 +0100 4192681 http://www.medworm.com/index.php?rid=4192680&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00464.x Conclusion MICA, MICB and NKG2D were upregulated in conolic mucosa of UC, and associated with activating of NK cells with promoted NKG2D and IFN‐γ production. (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4192680 Wed, 24 Nov 2010 04:56:33 +0100 4192680 http://www.medworm.com/index.php?rid=4176458&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00467.x (Source: Chinese Journal of Digestive Diseases) Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4176458 Wed, 17 Nov 2010 00:00:00 +0100 4176458 http://www.medworm.com/index.php?rid=4176457&cid=s_30390_17_f&fid=30390&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-2980.2010.00468.x AbstractThe development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non‐parenchymal cells in the liver. The impact of ethanol on hepatocytes can be characterized as a condition of “organelle stress” with multi‐factorial changes in hepatocellular function accumulating during ethanol exposure. These changes include oxidative stress, mitochondrial dysfunction, decreased methylation capacity, endoplasmic reticulum stress, impaired vesicular trafficking and altered proteosome function. Injury to hepatocytes is attributed, in part, to ethanol metabolism by the hepatocytes. Changes in the structural integrety of hepatic sinusoidal endotheial cells, as well as enhanced inflammation in the liver during ethanol exposure are also important contribu... Chinese Journal of Digestive Diseases journals http://www.medworm.com/rss/comments.php?id=4176457 Wed, 17 Nov 2010 00:00:00 +0100 4176457