MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Circulation Research' source. Wed, 08 Feb 2012 09:32:34 +0100 http://www.medworm.com/index.php?rid=5642916&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282193%26dopt%3DAbstract Conclusions:These results demonstrate the critical role of Necl-5 in angiogenesis and suggest that Necl-5 may regulate the VEGF-induced angiogenesis by controlling the interaction of VEGFR2 with integrin α(v)β(3), and the VEGFR2-mediated Rap1-Akt signaling pathway. PMID: 22282193 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5642916 Thu, 26 Jan 2012 05:00:00 +0100 5642916 http://www.medworm.com/index.php?rid=5642915&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282194%26dopt%3DAbstract Conclusions:By targeting distinct pathogenic mechanisms, isoform-selective HDAC inhibitors have potential as novel therapeutics for pulmonary hypertension that will complement vasodilator standards of care. PMID: 22282194 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5642915 Thu, 26 Jan 2012 05:00:00 +0100 5642915 http://www.medworm.com/index.php?rid=5642914&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282195%26dopt%3DAbstract Conclusions:Dll1 acts as an extrinsic cue involved in tip cell selection, which directs vessel sprouting and branch formation. PMID: 22282195 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5642914 Thu, 26 Jan 2012 05:00:00 +0100 5642914 http://www.medworm.com/index.php?rid=5642913&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282196%26dopt%3DAbstract Conclusions:Costimulatory pathways are altered in CD4(+)CD28(null) T cells in ACS. We show that the inflammatory and cytotoxic function of CD4(+)CD28(null) T cells can be inhibited by blocking OX40 and 4 to 1BB costimulatory receptors. Modulation of costimulatory receptors may allow specific targeting of this cell subset and may improve the survival of ACS patients. PMID: 22282196 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5642913 Thu, 26 Jan 2012 05:00:00 +0100 5642913 http://www.medworm.com/index.php?rid=5642918&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275486%26dopt%3DAbstract Conclusions:Hyperamylinemia promotes amylin deposition in the heart, causing alterations of cardiac myocyte structure and function. We propose that detection and disruption of cardiac amylin buildup may be both a predictor of heart dysfunction and a novel therapeutic strategy in diabetic cardiomyopathy. PMID: 22275486 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5642918 Tue, 24 Jan 2012 05:00:00 +0100 5642918 http://www.medworm.com/index.php?rid=5642917&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275487%26dopt%3DAbstract Conclusions:Myocyte formation derived from CSC differentiation is the major determinant of cardiac growth during development. Division of c-kit-positive CSCs in the mouse is promoted by spontaneous Ca(2+) spikes, which dictate the pattern of stem cell replication and the generation of a myocyte progeny at all phases of prenatal life and up to one day after birth. PMID: 22275487 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5642917 Tue, 24 Jan 2012 05:00:00 +0100 5642917 http://www.medworm.com/index.php?rid=5624969&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267835%26dopt%3DAbstract Authors: Faber JE PMID: 22267835 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624969 Fri, 20 Jan 2012 05:00:00 +0100 5624969 http://www.medworm.com/index.php?rid=5624968&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267836%26dopt%3DAbstract Authors: Leistner DM, Zeiher AM PMID: 22267836 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624968 Fri, 20 Jan 2012 05:00:00 +0100 5624968 http://www.medworm.com/index.php?rid=5624967&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267837%26dopt%3DAbstract Authors: Schwartz RJ, Yeh ET PMID: 22267837 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624967 Fri, 20 Jan 2012 05:00:00 +0100 5624967 http://www.medworm.com/index.php?rid=5624966&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267838%26dopt%3DAbstract We reported that cardiac sympathetic rejuvenation occurs in cardiac hypertrophy and, moreover, interleukin-6 cytokines secreted from the failing myocardium induce cholinergic transdifferentiation of the cardiac sympathetic system via a gp130 signaling pathway, affecting cardiac performance and prognosis. In this review, we summarize the molecular mechanisms involved in sympathetic development, maturation, and transdifferentiation, and propose their investigation as new therapeutic targets for heart disease. PMID: 22267838 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624966 Fri, 20 Jan 2012 05:00:00 +0100 5624966 http://www.medworm.com/index.php?rid=5624965&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267839%26dopt%3DAbstract Authors: Stylianou IM, Bauer RC, Reilly MP, Rader DJ Abstract Atherosclerosis is a complex and heritable disease involving multiple cell types and the interactions of many different molecular pathways. The genetic and molecular mechanisms of atherosclerosis have, in part, been elucidated by mouse models; at least 100 different genes have been shown to influence atherosclerosis in mice. Importantly, unbiased genome-wide association studies have recently identified a number of novel loci robustly associated with atherosclerotic coronary artery disease. Here, we review the genetic data elucidated from mouse models of atherosclerosis, as well as significant associations for human coronary artery disease. Furthermore, we discuss in greater detail some of these novel human coronary arter... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624965 Fri, 20 Jan 2012 05:00:00 +0100 5624965 http://www.medworm.com/index.php?rid=5624964&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267840%26dopt%3DAbstract Authors: Angelillo-Scherrer A Abstract Leukocyte-derived microparticles (LMPs) may originate from neutrophils, monocytes/macrophages, and lymphocytes. They express markers from their parental cells and harbor membrane and cytoplasmic proteins as well as bioactive lipids implicated in a variety of mechanisms, maintaining or disrupting vascular homeostasis. When they carry tissue factor or coagulation inhibitors, they participate in hemostasis and pathological thrombosis. Both proinflammatory and anti-inflammatory processes can be affected by LMPs, thus ensuring an appropriate inflammatory response. LMPs also play a dual role in the endothelium by either improving the endothelial function or inducing an endothelial dysfunction. LMPs are implicated in all stages of atherosclerosis. Th... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624964 Fri, 20 Jan 2012 05:00:00 +0100 5624964 http://www.medworm.com/index.php?rid=5624963&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267842%26dopt%3DAbstract Conclusions:These data suggest a role for p90RSK in inhibiting CHIP activity and promoting cardiac apoptosis through binding to and phosphorylation of ERK5-S496. PMID: 22267842 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624963 Thu, 19 Jan 2012 05:00:00 +0100 5624963 http://www.medworm.com/index.php?rid=5624962&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22267843%26dopt%3DAbstract Conclusions:These data demonstrate the essential role for TXNIP in mediating EC-leukocyte adhesion under d-flow, as well as define a novel mechanism by which TXNIP acts as a transcriptional corepressor to regulate Kruppel-like factor 2-dependent gene expression. PMID: 22267843 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624962 Thu, 19 Jan 2012 05:00:00 +0100 5624962 http://www.medworm.com/index.php?rid=5624970&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22253411%26dopt%3DAbstract Conclusions:DHF is associated with regional remodeling of the t-system. Myocytes undergo substantial structural and functional restoration after only 3 weeks of CRT. The finding suggests that t-system status can provide an early marker of the success of this therapy. The results could also guide us to an understanding of the loss and remodeling of proteins associated with the t-system. The steep relationship between free Ca(2+) and contraction suggests that some restoration of Ca(2+) release units will have a disproportionately large effect on contractility. PMID: 22253411 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5624970 Tue, 17 Jan 2012 05:00:00 +0100 5624970 http://www.medworm.com/index.php?rid=5604965&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22247485%26dopt%3DAbstract Conclusions:Bmp signaling exerts opposing effects on myocardial differentiation in the embryo by promoting as well as inhibiting cardiac growth. PMID: 22247485 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5604965 Thu, 12 Jan 2012 05:00:00 +0100 5604965 http://www.medworm.com/index.php?rid=5579022&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223203%26dopt%3DAbstract Authors: PMID: 22223203 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579022 Fri, 06 Jan 2012 05:00:00 +0100 5579022 http://www.medworm.com/index.php?rid=5579021&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223204%26dopt%3DAbstract Authors: Pritchard S, Bianchi DW PMID: 22223204 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579021 Fri, 06 Jan 2012 05:00:00 +0100 5579021 http://www.medworm.com/index.php?rid=5579020&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223205%26dopt%3DAbstract Authors: Braunwald E PMID: 22223205 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579020 Fri, 06 Jan 2012 05:00:00 +0100 5579020 http://www.medworm.com/index.php?rid=5579019&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223206%26dopt%3DAbstract Authors: Norris AW, Sigmund CD PMID: 22223206 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579019 Fri, 06 Jan 2012 05:00:00 +0100 5579019 http://www.medworm.com/index.php?rid=5579018&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223207%26dopt%3DAbstract Authors: Tomaselli GF PMID: 22223207 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579018 Fri, 06 Jan 2012 05:00:00 +0100 5579018 http://www.medworm.com/index.php?rid=5579017&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223208%26dopt%3DAbstract Authors: McCarthy A PMID: 22223208 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579017 Fri, 06 Jan 2012 05:00:00 +0100 5579017 http://www.medworm.com/index.php?rid=5579016&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223209%26dopt%3DAbstract Authors: Coggins M, Rosenzweig A Abstract Inflammatory mediators are operative in the pathogenesis of the most common forms of heart disease. Although in most cases the induction of these pathways is maladaptive and deleterious, there are notable exceptions when inflammatory pathways participate in healing or limiting the extent of injury. The appreciation of the role of these mechanisms in myocardial homeostasis and pathophysiology has led to increased efforts to elucidate the specific signaling pathways most relevant to the heart. Our goal in this introductory overview is to provide context for the five detailed reviews that follow by introducing the major relevant stimuli, the receptors, and pathways that mediate inflammatory signaling in the heart. We try to impart a sense of t... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579016 Fri, 06 Jan 2012 05:00:00 +0100 5579016 http://www.medworm.com/index.php?rid=5579015&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223210%26dopt%3DAbstract Authors: Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM Abstract Inflammatory processes underlie a broad spectrum of conditions that injure the heart muscle and cause both structural and functional deficits. In this article, we address current knowledge regarding 4 common forms of myocardial inflammation: myocardial ischemia and reperfusion, sepsis, viral myocarditis, and immune rejection. Each of these pathological states has its own unique features in pathogenesis and disease evolution, but all reflect inflammatory mechanisms that are partially shared. From the point of injury to the mobilization of innate and adaptive immune responses and inflammatory amplification, the cellular and soluble mediators and mechanisms examined in this review will be discussed... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579015 Fri, 06 Jan 2012 05:00:00 +0100 5579015 http://www.medworm.com/index.php?rid=5579014&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223211%26dopt%3DAbstract Authors: Kaya Z, Leib C, Katus HA Abstract Human heart failure is a disease with multifactorial causes, considerable morbidity, and high mortality. Several circulating autoantibodies, some of them being heart-specific, play a crucial role in the progression and induction of heart failure. However the precise mechanisms on how these autoantibodies perpetuate or even induce an organ specific autoimmune response are not yet fully understood. Also it is being a matter of current research to elucidate a potential pathophysiological role of the innate immune system in generating auto-reactive antibodies. In this review we will summarize the current available literature on circulating autoantibodies which are related to human heart failure. We will present clinical and animal studies that... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579014 Fri, 06 Jan 2012 05:00:00 +0100 5579014 http://www.medworm.com/index.php?rid=5579013&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223212%26dopt%3DAbstract Authors: Frangogiannis NG Abstract Myocardial necrosis triggers an inflammatory reaction that clears the wound from dead cells and matrix debris, while activating reparative pathways necessary for scar formation. A growing body of evidence suggests that accentuation, prolongation, or expansion of the postinfarction inflammatory response results in worse remodeling and dysfunction following myocardial infarction. This review manuscript discusses the cellular effectors and endogenous molecular signals implicated in suppression and containment of the inflammatory response in the infarcted heart. Clearance of apoptotic neutrophils, recruitment of inhibitory monocyte subsets and regulatory T cells, macrophage differentiation and pericyte/endothelial interactions may play an active role ... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579013 Fri, 06 Jan 2012 05:00:00 +0100 5579013 http://www.medworm.com/index.php?rid=5579012&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223213%26dopt%3DAbstract Authors: Kolattukudy PE, Niu J Abstract Numerous inflammatory cytokines have been implicated in the pathogenesis of cardiovascular diseases. Monocyte chemoattractant protein (MCP)-1/CCL2 is expressed by mainly inflammatory cells and stromal cells such as endothelial cells, and its expression is upregulated after proinflammatory stimuli and tissue injury. MCP-1 can function as a traditional chemotactic cytokine and also regulates gene transcription. The recently discovered novel zinc-finger protein, called MCPIP (MCP-1-induced protein), initiates a series of signaling events that causes oxidative and endoplasmic reticulum (ER) stress, leading to autophagy that can result in cell death or differentiation, depending on the cellular context. After a brief review of the basic processes ... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579012 Fri, 06 Jan 2012 05:00:00 +0100 5579012 http://www.medworm.com/index.php?rid=5579011&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223214%26dopt%3DAbstract Authors: Edwards G, Félétou M, Weston AH PMID: 22223214 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579011 Fri, 06 Jan 2012 05:00:00 +0100 5579011 http://www.medworm.com/index.php?rid=5579010&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223215%26dopt%3DAbstract Authors: Bergmann O, Zdunek S, Frisén J, Bernard S, Druid H, Jovinge S PMID: 22223215 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579010 Fri, 06 Jan 2012 05:00:00 +0100 5579010 http://www.medworm.com/index.php?rid=5579009&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223353%26dopt%3DAbstract Conclusions:The attainment of a certain threshold [Ca(2+)](SR) is not sufficient for the generation of DCWs. Postrelease Ca(2+) signaling refractoriness critically influences the occurrence of spontaneous Ca(2+) waves in the diastolic period. Shortened Ca(2+) signaling refractoriness due to RyR2 phosphorylation and oxidation is responsible for the increased rate of DCWs observed in VF myocytes. PMID: 22223353 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579009 Thu, 05 Jan 2012 05:00:00 +0100 5579009 http://www.medworm.com/index.php?rid=5579008&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223354%26dopt%3DAbstract Conclusions:Coro1A controls actin association with endocytic organelles, thereby negatively regulating endo-lysosomal delivery, degradation of modified lipoproteins and cholesterol deposition in macrophages. PMID: 22223354 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579008 Thu, 05 Jan 2012 05:00:00 +0100 5579008 http://www.medworm.com/index.php?rid=5579007&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223355%26dopt%3DAbstract Conclusions:Our results show that adult stem cells retain inherent LR asymmetry that elicits de novo macroscale tissue morphogenesis, indicating that mechanical induction is required for cellular LR specification. PMID: 22223355 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5579007 Thu, 05 Jan 2012 05:00:00 +0100 5579007 http://www.medworm.com/index.php?rid=5562796&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207709%26dopt%3DAbstract Conclusions:The present data suggest that ligand-dependent formation of HMGA1-Ubc9-PPARγ complexes facilitates PPARγ SUMOylation, which results in the prevention of SMRT corepressor clearance and induction of MMP-9 transrepression. These data provide new information on PPARγ-dependent vascular transcriptional regulation and help us to understand the molecular consequences of therapeutic interventions with PPARγ ligands in the vasculature. PMID: 22207709 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5562796 Thu, 29 Dec 2011 05:00:00 +0100 5562796 http://www.medworm.com/index.php?rid=5562795&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207710%26dopt%3DAbstract Conclusions:The results indicate that the FGF/FRS2α-mediated signals prevent premature differentiation of heart progenitor cells through suppressing autophagy. The findings provide the first evidence that autophagy plays a role in heart progenitor differentiation. PMID: 22207710 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5562795 Thu, 29 Dec 2011 05:00:00 +0100 5562795 http://www.medworm.com/index.php?rid=5562794&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207711%26dopt%3DAbstract Conclusions:Inhaled nitric oxide thus may provide a completely novel strategy to improve penumbral blood flow and neuronal survival in stroke or other ischemic conditions. PMID: 22207711 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5562794 Thu, 29 Dec 2011 05:00:00 +0100 5562794 http://www.medworm.com/index.php?rid=5562793&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207712%26dopt%3DAbstract Conclusions:The data indicate that vascular bioactivation of GTN is catalyzed by cytosolic ALDH2. Mitochondrial GTN metabolism may contribute to oxidative stress-related adverse effects of nitrate therapy and the development of nitrate tolerance. PMID: 22207712 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5562793 Thu, 29 Dec 2011 05:00:00 +0100 5562793 http://www.medworm.com/index.php?rid=5536887&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22194622%26dopt%3DAbstract Conclusions:We conclude that the absence of Nur77 in monocytes and macrophages results in enhanced toll-like receptor signaling and polarization of macrophages toward a proinflammatory M1 phenotype. Despite having fewer monocytes, Nur77(-/-) mice developed significant atherosclerosis when fed a Western diet. These studies indicate that Nur77 is a novel target for modulating the inflammatory phenotype of monocytes and macrophages and may be important for regulation of atherogenesis. PMID: 22194622 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5536887 Thu, 22 Dec 2011 05:00:00 +0100 5536887 http://www.medworm.com/index.php?rid=5536886&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22194623%26dopt%3DAbstract Conclusions:In conclusion, in bone marrow-derived cells the nuclear receptor Nur77 has an anti-inflammatory function, represses SDF-1α expression and inhibits atherosclerosis. PMID: 22194623 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5536886 Thu, 22 Dec 2011 05:00:00 +0100 5536886 http://www.medworm.com/index.php?rid=5536885&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22194624%26dopt%3DAbstract Conclusions:Our results identify ILK as a regulatory partner of eNOS in vivo that prevents eNOS uncoupling, and suggest ILK as a therapeutic target for prevention of endothelial dysfunction related to shear stress-induced vascular diseases. PMID: 22194624 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5536885 Thu, 22 Dec 2011 05:00:00 +0100 5536885 http://www.medworm.com/index.php?rid=5536889&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22179057%26dopt%3DAbstract Conclusions:Fibroblast proliferation in atria might be responsible for the genesis of CFAEs during persistent/permanent AF. Our findings could contribute to better understanding of the mechanisms underlying CFAE-targeted AF ablation. PMID: 22179057 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5536889 Wed, 21 Dec 2011 05:00:00 +0100 5536889 http://www.medworm.com/index.php?rid=5536888&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22179058%26dopt%3DAbstract Conclusions:Our data show that enhanced β(2)AR phosphorylation by GRK, in addition to PKA, leads the receptor to G(i)-biased signaling, which, in turn, contributes to the pathogenesis of heart failure, marking G(i)-biased β(2)AR signaling as a primary event linking upregulation of GRK to cardiac maladaptive remodeling, failure and cardiodepression. PMID: 22179058 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5536888 Wed, 21 Dec 2011 05:00:00 +0100 5536888 http://www.medworm.com/index.php?rid=5514769&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158646%26dopt%3DAbstract Authors: Belmonte SL, Blaxall BC PMID: 22158646 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514769 Fri, 09 Dec 2011 05:00:00 +0100 5514769 http://www.medworm.com/index.php?rid=5514768&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158647%26dopt%3DAbstract Authors: Inagami T PMID: 22158647 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514768 Fri, 09 Dec 2011 05:00:00 +0100 5514768 http://www.medworm.com/index.php?rid=5514767&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158648%26dopt%3DAbstract Authors: McCarthy A PMID: 22158648 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514767 Fri, 09 Dec 2011 05:00:00 +0100 5514767 http://www.medworm.com/index.php?rid=5514766&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158649%26dopt%3DAbstract Authors: Mohsin S, Siddiqi S, Collins B, Sussman MA Abstract Treatment strategies for heart failure remain a high priority for ongoing research due to the profound unmet need in clinical disease coupled with lack of significant translational progress. The underlying issue is the same whether the cause is acute damage, chronic stress from disease, or aging: progressive loss of functional cardiomyocytes and diminished hemodynamic output. To stave off cardiomyocyte losses, a number of strategic approaches have been embraced in recent years involving both molecular and cellular approaches to augment myocardial structure and performance. Resultant excitement surrounding regenerative medicine in the heart has been tempered by realizations that reparative processes in the heart are insuff... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514766 Fri, 09 Dec 2011 05:00:00 +0100 5514766 http://www.medworm.com/index.php?rid=5514765&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158650%26dopt%3DAbstract Authors: Pérez-Pomares JM, de la Pompa JL Abstract The epicardium, the tissue layer covering the cardiac muscle (myocardium), develops from the proepicardium, a mass of coelomic progenitors located at the venous pole of the embryonic heart. Proepicardium cells attach to and spread over the myocardium to form the primitive epicardial epithelium. The epicardium subsequently undergoes an epithelial-to-mesenchymal transition to give rise to a population of epicardium-derived cells, which in turn invade the heart and progressively differentiate into various cell types, including cells of coronary blood vessels and cardiac interstitial cells. Epicardial cells and epicardium-derived cells signal to the adjacent cardiac muscle in a paracrine fashion, promoting its proliferation and expans... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514765 Fri, 09 Dec 2011 05:00:00 +0100 5514765 http://www.medworm.com/index.php?rid=5514764&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158707%26dopt%3DAbstract Conclusions:We conclude that Tβ4 is dispensable for embryonic viability, heart development, coronary vessel development, and adult myocardial function. PMID: 22158707 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514764 Thu, 08 Dec 2011 05:00:00 +0100 5514764 http://www.medworm.com/index.php?rid=5514763&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158708%26dopt%3DAbstract Conclusions:Our study reveals a previously undescribed role of EZH2 in regulating heart formation and shows that perturbation of the epigenetic landscape early in cardiogenesis has sustained disruptive effects at later developmental stages. PMID: 22158708 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514763 Thu, 08 Dec 2011 05:00:00 +0100 5514763 http://www.medworm.com/index.php?rid=5514762&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158709%26dopt%3DAbstract Conclusions:FKBP12.6 mice exhibit AF caused by SR Ca(2+) leak, Na(+)/Ca(2+)-exchanger activation, and DADs, which promote triggered activity. Genetic inhibition of RyR2-S2814 phosphorylation prevents AF induction in FKBP12.6-/- mice by suppressing SR Ca(2+) leak and DADs. These results suggest suppression of RyR2-S2814 phosphorylation as a potential anti-AF therapeutic target. PMID: 22158709 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514762 Thu, 08 Dec 2011 05:00:00 +0100 5514762 http://www.medworm.com/index.php?rid=5514761&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22158710%26dopt%3DAbstract Conclusions:H(2)O(2) dilates HCAs through a novel mechanism involving protein dimerization and activation of PKG-Iα and subsequent opening of smooth muscle BK(Ca) channels. PMID: 22158710 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514761 Thu, 08 Dec 2011 05:00:00 +0100 5514761 http://www.medworm.com/index.php?rid=5514770&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22135404%26dopt%3DAbstract Conclusions:These findings identify mesodermal foxc1a/b as a direct upstream regulator of etsrp in angioblasts. This establishes a new molecular link in the process of mesoderm specification into angioblast. PMID: 22135404 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514770 Thu, 01 Dec 2011 05:00:00 +0100 5514770 http://www.medworm.com/index.php?rid=5514775&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116816%26dopt%3DAbstract Conclusions:BM-derived FSP-1(+) cells enhance neointima formation through an increase in transendothelial invasion with stimulation of SMC proliferation. The Rac1 and ERK5 signaling cascade mediate FSP-1-induced responses in SMCs and BM cells. This novel pathophysiology suggests a new therapeutic target, FSP-1, for preventing the development of neointima in vein grafts. PMID: 22116816 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514775 Wed, 23 Nov 2011 05:00:00 +0100 5514775 http://www.medworm.com/index.php?rid=5514774&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116817%26dopt%3DAbstract Conclusions:The identification of this unique signaling signature of RIPC will facilitate the development of pharmacological cardioprotection.Clinical Trial Registration:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01406678. PMID: 22116817 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514774 Wed, 23 Nov 2011 05:00:00 +0100 5514774 http://www.medworm.com/index.php?rid=5514773&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116818%26dopt%3DAbstract Conclusions:c-Myb is tightly regulated by proteosomal degradation during cardiovascular-directed differentiation of ESC, expanding early-stage VEGFR2+ progenitors capable of retinoic acid-responsive SMC formation. PMID: 22116818 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514773 Wed, 23 Nov 2011 05:00:00 +0100 5514773 http://www.medworm.com/index.php?rid=5514772&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116819%26dopt%3DAbstract Conclusions:We identify increased miR-29b expression as key to the pathogenesis of early aneurysm development in MFS by regulating aortic wall apoptosis and extracellular matrix abnormalities. PMID: 22116819 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514772 Wed, 23 Nov 2011 05:00:00 +0100 5514772 http://www.medworm.com/index.php?rid=5514771&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116820%26dopt%3DAbstract Conclusions:We designed a bipartite NFAT inhibitor that is more potent than VIVIT and more selective than CsA. MCV1 constitutes not only a powerful tool to unravel NFAT function but also a potential drug candidate for the treatment of diseases implicating NFAT activation. PMID: 22116820 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5514771 Wed, 23 Nov 2011 05:00:00 +0100 5514771 http://www.medworm.com/index.php?rid=5424037&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22095726%26dopt%3DAbstract Conclusions:Pressure overload depresses NO/heme-dependent sGC activation in the heart, consistent with enhanced oxidation. The data reveal a novel additional mechanism for reduced NO-coupled sGC activity related to dynamic shifts in membrane microdomain localization, with Cav3-microdomains protecting sGC from heme-oxidation and facilitating NO responsiveness. Translocation of sGC out of this domain favors sGC oxidation and contributes to depressed NO-stimulated sGC activity. PMID: 22095726 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424037 Thu, 17 Nov 2011 05:00:00 +0100 5424037 http://www.medworm.com/index.php?rid=5424036&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22095727%26dopt%3DAbstract Conclusions:The results of this study demonstrate for the first time in humans that myocardial infarct size and left ventricular function after STEMI have a circadian dependence on the time of day onset of ischemia. PMID: 22095727 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424036 Thu, 17 Nov 2011 05:00:00 +0100 5424036 http://www.medworm.com/index.php?rid=5424035&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22095728%26dopt%3DAbstract Conclusions:These results support the novel concept that acidification, by converting Ca(2+) waves to sparks, leads to the activation of BK(Ca) channels to induce dilation of cerebral PAs. PMID: 22095728 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424035 Thu, 17 Nov 2011 05:00:00 +0100 5424035 http://www.medworm.com/index.php?rid=5424034&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22095729%26dopt%3DAbstract Conclusions:We conclude that iVPCs, generated by partially reprogramming ECs, are an ideal cell type for cell-based therapy designed to stimulate coronary collateral growth. PMID: 22095729 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424034 Thu, 17 Nov 2011 05:00:00 +0100 5424034 http://www.medworm.com/index.php?rid=5424033&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22095730%26dopt%3DAbstract Conclusions:Our results indicate the involvement of the KCNQ1-S6 region at/or around A341 in cAMP-dependent stimulation of I(Ks), a process that is under strong dominant-negative control, suggesting that tetrameric KCNQ1 phosphorylation is required. Specific long-QT1 mutations, including heterozygous A341V, disable this regulation. PMID: 22095730 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424033 Thu, 17 Nov 2011 05:00:00 +0100 5424033 http://www.medworm.com/index.php?rid=5424038&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22082491%26dopt%3DAbstract Conclusions:Fetal maternal stem cell transfer appears to be a critical mechanism in the maternal response to cardiac injury. Furthermore, we have identified Cdx2 cells as a novel cell type for potential use in cardiovascular regenerative therapy. PMID: 22082491 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424038 Mon, 14 Nov 2011 05:00:00 +0100 5424038 http://www.medworm.com/index.php?rid=5424048&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076503%26dopt%3DAbstract Authors: Springer ML, Wang X PMID: 22076503 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424048 Fri, 11 Nov 2011 05:00:00 +0100 5424048 http://www.medworm.com/index.php?rid=5424047&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076504%26dopt%3DAbstract Opening the field of integrin biology to "biased agonism". Circ Res. 2011 Nov 11;109(11):1199-201 Authors: Simon DI PMID: 22076504 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424047 Fri, 11 Nov 2011 05:00:00 +0100 5424047 http://www.medworm.com/index.php?rid=5424046&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076505%26dopt%3DAbstract Authors: Chakravarti A PMID: 22076505 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424046 Fri, 11 Nov 2011 05:00:00 +0100 5424046 http://www.medworm.com/index.php?rid=5424045&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076506%26dopt%3DAbstract Authors: Sadoshima J, Hare JM PMID: 22076506 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424045 Fri, 11 Nov 2011 05:00:00 +0100 5424045 http://www.medworm.com/index.php?rid=5424044&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076507%26dopt%3DAbstract Authors: Laidman J PMID: 22076507 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424044 Fri, 11 Nov 2011 05:00:00 +0100 5424044 http://www.medworm.com/index.php?rid=5424039&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22080354%26dopt%3DAbstract Authors: PMID: 22080354 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424039 Fri, 11 Nov 2011 05:00:00 +0100 5424039 http://www.medworm.com/index.php?rid=5424043&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076634%26dopt%3DAbstract Conclusion:The α(1)-adrenergic stimulation releases Rem1 inhibition of VLCCs through direct phosphorylation of Rem1 at Ser18 by protein kinase D1, resulting in an increase of the channel activity and transverse-tubule expression. Our results uncover a novel molecular regulatory mechanism of VLCC trafficking and function in the heart and provide the first demonstration of physiological regulation of RGK function. PMID: 22076634 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424043 Thu, 10 Nov 2011 05:00:00 +0100 5424043 http://www.medworm.com/index.php?rid=5424042&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076635%26dopt%3DAbstract Conclusions:These results suggest that Fzd4 is a major receptor involved in arterial formation and organization through a Wnt/PCP pathway. PMID: 22076635 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424042 Thu, 10 Nov 2011 05:00:00 +0100 5424042 http://www.medworm.com/index.php?rid=5424041&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076636%26dopt%3DAbstract Conclusions:These findings demonstrate that Sema3E-generated avascular zones are critical regulators of mammalian cardiovascular patterning and are the first to identify a repulsive role for the lateral plate mesoderm. Integration of multiple, and in some cases redundant, repulsive cues from various tissues is critical to patterning the first embryonic blood vessels. PMID: 22076636 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424041 Thu, 10 Nov 2011 05:00:00 +0100 5424041 http://www.medworm.com/index.php?rid=5424040&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22076637%26dopt%3DAbstract Conclusion:These results indicate that LG3 is a novel regulator of obliterative vascular remodeling during rejection. PMID: 22076637 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5424040 Thu, 10 Nov 2011 05:00:00 +0100 5424040 http://www.medworm.com/index.php?rid=5382143&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22052914%26dopt%3DAbstract Conclusions:Oligonucleotide-based therapies using LNA-modified chemistries for modulating cardiac miRNAs in the setting of heart disease are efficacious and validate miR-15 as a potential therapeutic target for the manipulation of cardiac remodeling and function in the setting of ischemic injury. PMID: 22052914 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382143 Thu, 03 Nov 2011 04:00:00 +0100 5382143 http://www.medworm.com/index.php?rid=5382142&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22052915%26dopt%3DAbstract Conclusions:These results show that ATF-1 mediates HO-1 induction by heme and drives macrophage adaptation to intraplaque hemorrhage. Our definition of an ATF-1-mediated pathway for linked protection from foam cell formation and oxidant stress may have therapeutic potential. PMID: 22052915 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382142 Thu, 03 Nov 2011 04:00:00 +0100 5382142 http://www.medworm.com/index.php?rid=5382141&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22052916%26dopt%3DAbstract Conclusions:Mitochondrial fusion in adult cardiac myocytes is necessary to maintain normal mitochondrial morphology and is essential for normal cardiac respiratory and contractile function. Interruption of mitochondrial fusion causes lethal cardiac failure at a time corresponding to 3 or 4 cycles of unopposed mitochondrial fission. PMID: 22052916 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382141 Thu, 03 Nov 2011 04:00:00 +0100 5382141 http://www.medworm.com/index.php?rid=5382140&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22052917%26dopt%3DAbstract Conclusions:In this study, the delivery of MultiStem to the myocardium in patients with recent STEMI was well tolerated and safe. In patients who exhibited significant myocardial damage, the delivery of ≥50 million MultiStem resulted in improved EF and stroke volume 4 months later. These findings support further development of MultiStem in patients with AMI and they validate the potential of a system for delivery of adult stem cells at any time after primary percutaneous coronary intervention. PMID: 22052917 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382140 Thu, 03 Nov 2011 04:00:00 +0100 5382140 http://www.medworm.com/index.php?rid=5382153&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034476%26dopt%3DAbstract Authors: O'Rourke JR, Olson EN PMID: 22034476 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382153 Fri, 28 Oct 2011 04:00:00 +0100 5382153 http://www.medworm.com/index.php?rid=5382152&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034477%26dopt%3DAbstract Authors: Libby P, Folco E PMID: 22034477 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382152 Fri, 28 Oct 2011 04:00:00 +0100 5382152 http://www.medworm.com/index.php?rid=5382151&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034478%26dopt%3DAbstract Authors: Binder CJ, Witztum JL PMID: 22034478 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382151 Fri, 28 Oct 2011 04:00:00 +0100 5382151 http://www.medworm.com/index.php?rid=5382150&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034479%26dopt%3DAbstract Authors: Feldman AM PMID: 22034479 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382150 Fri, 28 Oct 2011 04:00:00 +0100 5382150 http://www.medworm.com/index.php?rid=5382149&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034480%26dopt%3DAbstract Authors: Bristow MR Abstract Despite the absence of a systematic development plan, β-blockers have reached the top tier of medical therapies for chronic heart failure. The successful outcome was due to the many dedicated investigators who produced, over a 30-year period, increasing evidence that β-blocking agents should or actually did improve the natural history of dilated cardiomyopathies and heart failure. It took 20 years for supportive evidence to become undeniable, at which time in 1993 the formidable drug development resources of large pharmaceutical companies were deployed into Phase 3 trials. Success then came relatively quickly, and within 8 years multiple agents were on the market in the United States and Europe. Importantly, there is ample room to improve antiadrenerg... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382149 Fri, 28 Oct 2011 04:00:00 +0100 5382149 http://www.medworm.com/index.php?rid=5382148&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034481%26dopt%3DAbstract Authors: Heidrich FM, Zhang K, Strasser RH PMID: 22034481 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382148 Fri, 28 Oct 2011 04:00:00 +0100 5382148 http://www.medworm.com/index.php?rid=5382147&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034490%26dopt%3DAbstract Conclusion:These results identify TSP4 as myocyte-interstitial mechano-signaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to play a crucial role in the transition to chronic cardiac dilatation and failure. PMID: 22034490 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382147 Thu, 27 Oct 2011 04:00:00 +0100 5382147 http://www.medworm.com/index.php?rid=5382146&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034491%26dopt%3DAbstract Conclusions:Our study identifies canonical Wnt signaling and the novel downstream mediator, IGFBP3, as key regulators of adult cardiac progenitor self-renewal in physiological and pathological states. PMID: 22034491 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382146 Thu, 27 Oct 2011 04:00:00 +0100 5382146 http://www.medworm.com/index.php?rid=5382145&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034492%26dopt%3DAbstract Conclusions:Our work provided a comprehensive set of methods to analyze mouse cardiac transcriptome complexity at individual exon and transcript levels. Applications of the methods may infer important new insights to gene regulation in normal and disease hearts in terms of exon utilization and potential involvement of novel components of cardiac transcriptome. PMID: 22034492 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382145 Thu, 27 Oct 2011 04:00:00 +0100 5382145 http://www.medworm.com/index.php?rid=5382144&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22034493%26dopt%3DAbstract Conclusions:Together, these results are the first to identify the Id3-CCR6 pathway in B cells and demonstrate its role in aortic B-cell homing and B-cell-mediated protection from early atherosclerosis. PMID: 22034493 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382144 Thu, 27 Oct 2011 04:00:00 +0100 5382144 http://www.medworm.com/index.php?rid=5382156&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22021929%26dopt%3DAbstract Conclusions:These results are the first to demonstrate that nitrite plays a critical role in the protection of endothelial barrier function against hypoxic insult. Our findings show that nitrite holds great potential for the treatment of diseases associated with hypoxia-associated disorder of vascular homeostasis. PMID: 22021929 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382156 Thu, 20 Oct 2011 04:00:00 +0100 5382156 http://www.medworm.com/index.php?rid=5382155&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22021930%26dopt%3DAbstract Conclusions:Our data reveal a protective role for PDC in atherosclerosis, possibly by dampening T-cell proliferation and activity in peripheral lymphoid tissue, rendering PDC an interesting target for future therapeutic interventions. PMID: 22021930 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382155 Thu, 20 Oct 2011 04:00:00 +0100 5382155 http://www.medworm.com/index.php?rid=5382154&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22021931%26dopt%3DAbstract Conclusions:Nuclear PG provokes adipogenesis in c-Kit(+) CPCs by repressing the canonical Wnt signaling and inducing a proadipogenic gene expression. The findings suggest that adipocytes in ARVC, at least in part, originate from c-Kit(+) CPCs. PMID: 22021931 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5382154 Thu, 20 Oct 2011 04:00:00 +0100 5382154 http://www.medworm.com/index.php?rid=5331349&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998296%26dopt%3DAbstract Authors: Port JD, Bristow MR PMID: 21998296 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331349 Fri, 14 Oct 2011 04:00:00 +0100 5331349 http://www.medworm.com/index.php?rid=5331348&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998297%26dopt%3DAbstract Authors: Kelly RG PMID: 21998297 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331348 Fri, 14 Oct 2011 04:00:00 +0100 5331348 http://www.medworm.com/index.php?rid=5331347&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998298%26dopt%3DAbstract Authors: Zhou Y, Kim J, Yuan X, Braun T Abstract Stem cells of all types are characterized by the ability to self-renew and to differentiate. Multiple lines of evidence suggest that both maintenance of stemness and lineage commitment, including determination of the cardiomyogenic lineage, are tightly controlled by epigenetic mechanisms such as DNA methylation, histone modifications, and ATP-dependent chromatin remodeling. Epigenetic mechanisms are intrinsically reversible, interdependent, and highly dynamic in regulation of chromatin structure and specific gene transcription programs, thereby contributing to stem cell homeostasis. Here, we review the current understanding of epigenetic mechanisms involved in regulation of stem cell self-renewal and differentiation and in the contro... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331347 Fri, 14 Oct 2011 04:00:00 +0100 5331347 http://www.medworm.com/index.php?rid=5331346&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998299%26dopt%3DAbstract Authors: Benian GM, Epstein HF Abstract The nematode Caenorhabditis elegans has become established as a major experimental organism with applications to many biomedical research areas. The body wall muscle cells are a useful model for the study of human cardiomyocytes and their homologous structures and proteins. The ability to readily identify mutations affecting these proteins and structures in C elegans and to be able to rigorously characterize their genotypes and phenotypes at the cellular and molecular levels permits mechanistic studies of the responsible interactions relevant to the inherited human cardiomyopathies. Future work in C elegans muscle holds great promise in uncovering new mechanisms in the pathogenesis of these cardiac disorders. PMID: 21998299 [PubMed - in p... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331346 Fri, 14 Oct 2011 04:00:00 +0100 5331346 http://www.medworm.com/index.php?rid=5331345&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998323%26dopt%3DAbstract Conclusions:Zebrafish may be a valuable preclinical tool to predict cardiotoxicity. The α-adrenergic signaling pathway is an important modulator of sorafenib cardiotoxicity in vitro and in vivo and appears to act through a here-to-fore unrecognized signaling pathway downstream of α-adrenergic activation that bypasses Raf to activate ERKs. PMID: 21998323 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331345 Fri, 14 Oct 2011 04:00:00 +0100 5331345 http://www.medworm.com/index.php?rid=5331344&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998324%26dopt%3DAbstract Conclusion:The above data indicated that Gal-1 regulates I(Ca,L) via decreasing the functional surface expression of Ca(V)1.2 channels in a splice variant selective manner and such a mechanism may play a role in modulating vascular constriction. PMID: 21998324 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331344 Thu, 13 Oct 2011 04:00:00 +0100 5331344 http://www.medworm.com/index.php?rid=5331343&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998325%26dopt%3DAbstract Conclusions:These studies demonstrate that CaMKIIδ(B) and δ(C) are not exclusively restricted to the nucleus and cytosol and that spatial and functional specificity in CaMKIIδ activation is elicited by mobilization of different Ca(2+) stores rather than by compartmentalized subtype localization. PMID: 21998325 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331343 Thu, 13 Oct 2011 04:00:00 +0100 5331343 http://www.medworm.com/index.php?rid=5331342&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998326%26dopt%3DAbstract Conclusions:We present the novel finding that CD40L binds to the EQLKKSKTL motif on Mac-1 mediating leukocyte recruitment and atherogenesis. Specific inhibition of CD40L-Mac-1 binding may represent an attractive anti-inflammatory treatment strategy for atherosclerosis and other inflammatory conditions, potentially avoiding the unwanted immunologic and thrombotic effects of global inhibition of CD40L. PMID: 21998326 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331342 Thu, 13 Oct 2011 04:00:00 +0100 5331342 http://www.medworm.com/index.php?rid=5331341&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998327%26dopt%3DAbstract Conclusions:These results provide additional evidence in a large animal model of disease that PKCα/β inhibition (with ruboxistaurin) represents a tenable and novel therapeutic approach for treating human heart failure. PMID: 21998327 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331341 Thu, 13 Oct 2011 04:00:00 +0100 5331341 http://www.medworm.com/index.php?rid=5331340&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21998328%26dopt%3DAbstract Conclusions:These studies demonstrated that CD4(+) T cells and complement operate independently to cause transplant ischemia during acute rejection and that sustained ischemia is a precursor to chronic rejection. PMID: 21998328 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5331340 Thu, 13 Oct 2011 04:00:00 +0100 5331340 http://www.medworm.com/index.php?rid=5300293&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21980123%26dopt%3DAbstract Conclusions:K(ATP) channel subunit gene expression is heterogeneously altered in the cardiomyopathic human heart. Blockade of K(ATP) channels promotes spontaneous defibrillation in cardiomyopathic human hearts by attenuating the ischemia-dependent spatiotemporal heterogeneity of refractoriness during early VF. PMID: 21980123 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5300293 Thu, 06 Oct 2011 04:00:00 +0100 5300293 http://www.medworm.com/index.php?rid=5300292&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21980124%26dopt%3DAbstract Conclusions:Our data support a causal role for mitochondrial STAT3 activation to mediate cardioprotection through better mitochondrial function. PMID: 21980124 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5300292 Thu, 06 Oct 2011 04:00:00 +0100 5300292 http://www.medworm.com/index.php?rid=5300291&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21980125%26dopt%3DAbstract Conclusions:These findings indicate that deletion of AMPKα2 through p52-Skp2-mediated ubiquintination and degradation of p27(Kip1) accentuates neointimal hyperplasia in response to wire injury. PMID: 21980125 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5300291 Thu, 06 Oct 2011 04:00:00 +0100 5300291 http://www.medworm.com/index.php?rid=5300290&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21980126%26dopt%3DAbstract Conclusions:These findings provide evidence that histone modifications epigenetically control the eNOS promoter in proangiogenic cells. PMID: 21980126 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5300290 Thu, 06 Oct 2011 04:00:00 +0100 5300290 http://www.medworm.com/index.php?rid=5300289&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21980127%26dopt%3DAbstract Conclusions:H(2)S is a major EDHF that causes vascular endothelial and smooth muscle cell hyperpolarization and vasorelaxation by activating the ATP-sensitive, intermediate conductance and small conductance potassium channels through cysteine S-sulfhydration. Because EDHF activity is a principal determinant of vasorelaxation in numerous vascular beds, drugs influencing H(2)S biosynthesis offer therapeutic potential. PMID: 21980127 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5300289 Thu, 06 Oct 2011 04:00:00 +0100 5300289 http://www.medworm.com/index.php?rid=5282578&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960720%26dopt%3DAbstract Authors: Priori SG PMID: 21960720 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282578 Fri, 30 Sep 2011 04:00:00 +0100 5282578 http://www.medworm.com/index.php?rid=5282577&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960721%26dopt%3DAbstract Authors: Miano JM, Small EM PMID: 21960721 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282577 Fri, 30 Sep 2011 04:00:00 +0100 5282577 http://www.medworm.com/index.php?rid=5282576&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960722%26dopt%3DAbstract Authors: Mummery CL, Passier R PMID: 21960722 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282576 Fri, 30 Sep 2011 04:00:00 +0100 5282576 http://www.medworm.com/index.php?rid=5282575&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960723%26dopt%3DAbstract Authors: Dimmeler S, Losordo D PMID: 21960723 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282575 Fri, 30 Sep 2011 04:00:00 +0100 5282575 http://www.medworm.com/index.php?rid=5282574&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960724%26dopt%3DAbstract Authors: Segers VF, Lee RT Abstract Transplantation of stem cells into the heart can improve cardiac function after myocardial infarction and in chronic heart failure, but the extent of benefit and of reproducibility of this approach are insufficient. Survival of transplanted cells into myocardium is poor, and new strategies are needed to enhance stem cell differentiation and survival in vivo. In this review, we describe how biomaterials can enhance stem cell function in the heart. Biomaterials can mimic or include naturally occurring extracellular matrix and also instruct stem cell function in different ways. Biomaterials can promote angiogenesis, enhance engraftment and differentiation of stem cells, and accelerate electromechanical integration of transplanted stem cells. Biomate... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282574 Fri, 30 Sep 2011 04:00:00 +0100 5282574 http://www.medworm.com/index.php?rid=5282573&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960725%26dopt%3DAbstract This article reviews the current understanding of MSC biology, mechanism of action in cardiac repair, translational findings, and early clinical trial data of MSC therapy for cardiac disease. PMID: 21960725 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282573 Fri, 30 Sep 2011 04:00:00 +0100 5282573 http://www.medworm.com/index.php?rid=5282572&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960726%26dopt%3DAbstract Authors: Leri A, Kajstura J, Anversa P Abstract For nearly a century, the human heart has been viewed as a terminally differentiated postmitotic organ in which the number of cardiomyocytes is established at birth, and these cells persist throughout the lifespan of the organ and organism. However, the discovery that cardiac stem cells live in the heart and differentiate into the various cardiac cell lineages has changed profoundly our understanding of myocardial biology. Cardiac stem cells regulate myocyte turnover and condition myocardial recovery after injury. This novel information imposes a reconsideration of the mechanisms involved in myocardial aging and the progression of cardiac hypertrophy to heart failure. Similarly, the processes implicated in the adaptation of the infarc... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282572 Fri, 30 Sep 2011 04:00:00 +0100 5282572 http://www.medworm.com/index.php?rid=5282571&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21960727%26dopt%3DAbstract Authors: Nguyen PK, Lan F, Wang Y, Wu JC Abstract Stem cells have been touted as the holy grail of medical therapy, with promises to regenerate cardiac tissue, but it appears the jury is still out on this novel therapy. Using advanced imaging technology, scientists have discovered that these cells do not survive nor engraft long-term. In addition, only marginal benefit has been observed in large-animal studies and human trials. However, all is not lost. Further application of advanced imaging technology will help scientists unravel the mysteries of stem cell therapy and address the clinical hurdles facing its routine implementation. In this review, we will discuss how advanced imaging technology will help investigators better define the optimal delivery method, improve survival and... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282571 Fri, 30 Sep 2011 04:00:00 +0100 5282571 http://www.medworm.com/index.php?rid=5282581&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21959218%26dopt%3DAbstract Conclusions:Taken together, our studies demonstrate that MI-induced EPC mobilization was impaired in IL-10 KO mice and that IL-10 increases EPC survival and function possibly through activation of STAT3/VEGF signaling cascades, leading to attenuation of MI-induced left ventricular dysfunction and remodeling. PMID: 21959218 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282581 Thu, 29 Sep 2011 04:00:00 +0100 5282581 http://www.medworm.com/index.php?rid=5282580&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21959219%26dopt%3DAbstract Conclusions:Our data show that lipid accumulation and inflammation are dissociated in the vessel wall in mice with Rip2(-/-) macrophages. These results for the first time identify Rip2 as a key regulator of cellular lipid metabolism and cardiovascular disease. PMID: 21959219 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282580 Thu, 29 Sep 2011 04:00:00 +0100 5282580 http://www.medworm.com/index.php?rid=5282579&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21959220%26dopt%3DAbstract Conclusions:These results indicate that Hdac3 plays a critical and specific regulatory role in the neural crest-derived smooth muscle lineage and in formation of the OFT. PMID: 21959220 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5282579 Thu, 29 Sep 2011 04:00:00 +0100 5282579 http://www.medworm.com/index.php?rid=5263566&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21940940%26dopt%3DAbstract Conclusions:CRP antagonism of eNOS is mediated by the coupling of FcγRI to FcγRIIB by Src kinase and resulting activation of SH2 domain-containing inositol 5'-phosphatase 1 and, consistent with this mechanism, both FcγRI and FcγRIIB are required for CRP to blunt endothelial repair in vivo. Similar mechanisms underlie eNOS antagonism by immune complex. FcγRI and FcγRIIB may be novel therapeutic targets for preventing endothelial dysfunction in inflammatory or immune complex-mediated conditions. PMID: 21940940 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5263566 Thu, 22 Sep 2011 04:00:00 +0100 5263566 http://www.medworm.com/index.php?rid=5234238&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921269%26dopt%3DAbstract Authors: Zweier JL, Chen CA, Talukder MA PMID: 21921269 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234238 Fri, 16 Sep 2011 04:00:00 +0100 5234238 http://www.medworm.com/index.php?rid=5234237&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921270%26dopt%3DAbstract Authors: Okita K, Nagata N, Yamanaka S PMID: 21921270 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234237 Fri, 16 Sep 2011 04:00:00 +0100 5234237 http://www.medworm.com/index.php?rid=5234236&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921271%26dopt%3DAbstract Authors: Robbins J PMID: 21921271 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234236 Fri, 16 Sep 2011 04:00:00 +0100 5234236 http://www.medworm.com/index.php?rid=5234235&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921272%26dopt%3DAbstract Authors: Wolf MJ, Rockman HA Abstract The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century, but only over the past few decades has this tremendous resource been the focus of cardiovascular research. Fly genetics offers sophisticated transgenic systems, molecularly defined genomic deficiencies, genome-wide transgenic RNAi lines, and numerous curated mutants to perform genetic screens. As a genetically tractable model, the fly facilitates gene discovery and can complement mammalian models of disease. The circulatory system in the fly comprises well-defined sets of cardiomyocytes, and methodological advances have permitted accurate characterization of cardiac morphology and function. Thus, fly genetics and genomics of... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234235 Fri, 16 Sep 2011 04:00:00 +0100 5234235 http://www.medworm.com/index.php?rid=5234234&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921273%26dopt%3DAbstract Authors: Roden DM, Johnson JA, Kimmel SE, Krauss RM, Medina MW, Shuldiner A, Wilke RA Abstract Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented. PMID: 21921273 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234234 Fri, 16 Sep 2011 04:00:00 +0100 5234234 http://www.medworm.com/index.php?rid=5234244&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921263%26dopt%3DAbstract Conclusions:Our study provides a novel tool and insights into ionic bases of atrioventricular AP differences, and shows how Na(+) and Ca(2+) homeostasis critically mediate abnormal repolarization in AF. PMID: 21921263 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234244 Thu, 15 Sep 2011 04:00:00 +0100 5234244 http://www.medworm.com/index.php?rid=5234243&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921264%26dopt%3DAbstract Conclusions:This study documents the propensity of immature cardiomyocytes to terminally differentiate and mature in EHT in a remarkably organotypic manner. It moreover provides the rationale for the utility of the EHT technology as a methodological bridge between 2D cell culture and animal models. PMID: 21921264 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234243 Thu, 15 Sep 2011 04:00:00 +0100 5234243 http://www.medworm.com/index.php?rid=5234242&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921265%26dopt%3DAbstract Conclusions:These data obtained from a contrasting heterogeneous model system provide strong evidence that genetic segregation for aerobic exercise capacity can be linked with longevity and useful for deeper mechanistic exploration. PMID: 21921265 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234242 Thu, 15 Sep 2011 04:00:00 +0100 5234242 http://www.medworm.com/index.php?rid=5234241&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921266%26dopt%3DAbstract Conclusions:The results suggest that α-SMA containing stress fibers importantly contribute to myofibroblast arrhythmogeneicity. After ablation of this cytoskeletal component, cells lose their arrhythmic effects on cardiomyocytes, even if heterocellular electrotonic coupling is sustained. The findings identify α-SMA containing stress fibers as a potential future target of antiarrhythmic therapy in hearts undergoing structural remodeling. PMID: 21921266 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234241 Thu, 15 Sep 2011 04:00:00 +0100 5234241 http://www.medworm.com/index.php?rid=5234240&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921267%26dopt%3DAbstract Conclusions:AMPK regulates the transcription of Atrogin-1 and MuRF1 and enhances UPS-mediated protein degradation in heart. Specifically, AMPK regulates MuRF1 through the transcription factor MEF2. The absence of MuRF1 in the heart preserves cardiac function during fasting. The results strengthen the hypothesis that AMPK serves as a modulator of intracellular protein degradation in the heart. PMID: 21921267 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234240 Thu, 15 Sep 2011 04:00:00 +0100 5234240 http://www.medworm.com/index.php?rid=5234239&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21921268%26dopt%3DAbstract Conclusion:Hypoxic regions are present in murine plaques. Hypoxic macrophages have increased sterol content due to the induction of sterol synthesis and the suppression of cholesterol efflux, effects that are in part mediated by HIF-1α. PMID: 21921268 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5234239 Thu, 15 Sep 2011 04:00:00 +0100 5234239 http://www.medworm.com/index.php?rid=5220076&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903936%26dopt%3DAbstract Conclusions:PKC isoforms differentially modulate I(KACh), with conventional Ca(2+)-dependent isoforms inhibiting and novel isoforms enhancing activity. ATR causes a rate-dependent PKC isoform switch, with Ca(2+)/calpain-dependent downregulation of inhibitory PKCα and membrane translocation of stimulatory PKCε, enhancing I(KAChC). These findings provide novel insights into mechanisms underlying I(KAChC )dysregulation in AF. PMID: 21903936 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5220076 Thu, 08 Sep 2011 04:00:00 +0100 5220076 http://www.medworm.com/index.php?rid=5220075&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903937%26dopt%3DAbstract Conclusions:PDE4D regulates basal cAMP levels in SR microdomains through its interactions with SERCA2a-PLN. Because whole-cell Ca(2+) transient amplitudes are reduced in failing human myocardium, these observations may have therapeutic implications for patients with heart failure. PMID: 21903937 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5220075 Thu, 08 Sep 2011 04:00:00 +0100 5220075 http://www.medworm.com/index.php?rid=5220074&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903938%26dopt%3DAbstract Conclusion:In conclusion, miR-29-mediated downregulation of ECM proteins may sensitize the aorta to the formation of aneurysms in advanced age. Inhibition of miR-29 in vivo abrogates aortic dilation in mice, suggesting that miR-29 may represent a novel molecular target to augment matrix synthesis and maintain vascular wall structural integrity. PMID: 21903938 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5220074 Thu, 08 Sep 2011 04:00:00 +0100 5220074 http://www.medworm.com/index.php?rid=5220073&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21903939%26dopt%3DAbstract Conclusions:We propose that HCN3 together with other members of the HCN channel family confer a depolarizing background current that regulates ventricular resting potential and counteracts the action of hyperpolarizing potassium currents in late repolarization. In conclusion, our data indicate that HCN3 plays an important role in shaping the cardiac action potential waveform. PMID: 21903939 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5220073 Thu, 08 Sep 2011 04:00:00 +0100 5220073 http://www.medworm.com/index.php?rid=5194892&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885832%26dopt%3DAbstract Authors: Bolli R PMID: 21885832 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194892 Thu, 01 Sep 2011 23:00:00 +0100 5194892 http://www.medworm.com/index.php?rid=5194891&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885833%26dopt%3DAbstract Authors: Pandya K, Smithies O PMID: 21885833 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194891 Thu, 01 Sep 2011 23:00:00 +0100 5194891 http://www.medworm.com/index.php?rid=5194890&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885834%26dopt%3DAbstract Authors: Li D, Epstein JA PMID: 21885834 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194890 Thu, 01 Sep 2011 23:00:00 +0100 5194890 http://www.medworm.com/index.php?rid=5194889&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885835%26dopt%3DAbstract Authors: Morrisey EE PMID: 21885835 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194889 Thu, 01 Sep 2011 23:00:00 +0100 5194889 http://www.medworm.com/index.php?rid=5194888&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885836%26dopt%3DAbstract This article reviews the different estrogen receptors and their signaling mechanisms, discusses mechanisms that regulate estrogen receptor levels and locations, and considers the cardiovascular effects of estrogen signaling. PMID: 21885836 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194888 Thu, 01 Sep 2011 23:00:00 +0100 5194888 http://www.medworm.com/index.php?rid=5194887&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885837%26dopt%3DAbstract Authors: Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM Abstract Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is common in CKD patients and drives vascular calcification. In this article, we review the physiological regulatory mechanisms for Ca and P homeostasis and the basis for their dysregulation in CKD. In addition, we highlight recent findings indicating that elevated Ca and P have direct effects on vascular smooth muscle cells (VSMCs) that promote vascular calcification, including stimulation of osteogenic/chondrogenic differentiation, vesicle release, apoptosis, loss of inhibitors, and extracellular matrix degradation. These studies su... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194887 Thu, 01 Sep 2011 23:00:00 +0100 5194887 http://www.medworm.com/index.php?rid=5194886&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885838%26dopt%3DAbstract Authors: Watanabe H, Steele DS, Knollmann BC PMID: 21885838 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194886 Thu, 01 Sep 2011 23:00:00 +0100 5194886 http://www.medworm.com/index.php?rid=5194895&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885829%26dopt%3DAbstract Conclusions:We show that VEGF-A production is upregulated in medial SMCs of human atheromatous aortas and that peroxisome proliferator-activated receptor-γ agonists derived from early intimal lesions are likely to contribute to this phenotypic change. Our findings suggest that medial SMCs are central organizers of an angiogenic response initiated by the subendothelial accumulation of atherogenic lipids. PMID: 21885829 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194895 Wed, 31 Aug 2011 23:00:00 +0100 5194895 http://www.medworm.com/index.php?rid=5194894&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885830%26dopt%3DAbstract Conclusion:We demonstrate that p63RhoGEF selectively couples Gα(q/11) but not Gα(12/13), to RhoA activation in blood vessels and cultured cells and thus mediates the physiologically important Ca(2+) sensitization of force induced with Gα(q/11)-coupled agonists. Our results suggest that signaling through p63RhoGEF provides a novel mechanism for selective regulation of blood pressure. PMID: 21885830 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194894 Wed, 31 Aug 2011 23:00:00 +0100 5194894 http://www.medworm.com/index.php?rid=5194893&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885831%26dopt%3DAbstract Conclusions:Our results indicate that icMSCs improve function in hibernating myocardium independent of coronary flow or reduced scar volume. This arises from stimulation of myocyte proliferation with increases in cKit(+)/CD133(+) bone marrow progenitor cells and cKit(+)/CD133(-) resident stem cells, which increase myocyte number and reduce cellular hypertrophy. PMID: 21885831 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5194893 Wed, 31 Aug 2011 23:00:00 +0100 5194893 http://www.medworm.com/index.php?rid=5179405&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868694%26dopt%3DAbstract Conclusions:B1a lymphocytes are an atheroprotective B-lymphocyte population. Our data suggest that natural IgM secreted by these lymphocytes offers protection by depositing IgM in atherosclerotic lesions, which reduces the necrotic cores of lesions. PMID: 21868694 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5179405 Wed, 24 Aug 2011 23:00:00 +0100 5179405 http://www.medworm.com/index.php?rid=5179404&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868695%26dopt%3DAbstract Conclusion:SVP transplantation produces long-term improvement of cardiac function through a novel paracrine mechanism involving the secretion of miR-132 and inhibition of its target genes. PMID: 21868695 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5179404 Wed, 24 Aug 2011 23:00:00 +0100 5179404 http://www.medworm.com/index.php?rid=5179403&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868696%26dopt%3DAbstract Conclusions:A specific aptamer that can neutralize cardiomyopathy associated human beta1-AABs in vitro has been identified and characterized, providing a framework for future in vivo testing of this treatment option in animal experiments. PMID: 21868696 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5179403 Wed, 24 Aug 2011 23:00:00 +0100 5179403 http://www.medworm.com/index.php?rid=5179402&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868697%26dopt%3DAbstract Conclusions:PAH may arise when regulatory T-cell (Treg) activity fails to control endothelial injury. These studies suggest that regulatory T cells normally function to limit vascular injury and may protect against the development of PAH. PMID: 21868697 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5179402 Wed, 24 Aug 2011 23:00:00 +0100 5179402 http://www.medworm.com/index.php?rid=5157890&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852550%26dopt%3DAbstract Conclusions: Our data show that miR-133 is a key regulator of vascular smooth muscle cell phenotypic switch in vitro and in vivo, suggesting its potential therapeutic application for vascular diseases. PMID: 21852550 [PubMed - as supplied by publisher] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5157890 Thu, 18 Aug 2011 23:00:00 +0100 5157890 http://www.medworm.com/index.php?rid=5157881&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852552%26dopt%3DAbstract Authors: Ryan JJ, Rehman J, Archer SL PMID: 21852552 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5157881 Thu, 18 Aug 2011 23:00:00 +0100 5157881 http://www.medworm.com/index.php?rid=5157880&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852553%26dopt%3DAbstract Authors: Jay SM, Lee RT PMID: 21852553 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5157880 Thu, 18 Aug 2011 23:00:00 +0100 5157880 http://www.medworm.com/index.php?rid=5157879&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852554%26dopt%3DAbstract Authors: Williams R PMID: 21852554 [PubMed - in process] (Source: Circulation Research) Circulation Research journals http://www.medworm.com/rss/comments.php?id=5157879 Thu, 18 Aug 2011 23:00:00 +0100 5157879 http://www.medworm.com/index.php?rid=5157878&cid=s_38027_7_f&fid=38027&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21852555%26dopt%3DAbstract Authors: Boström KI, Rajamannan NM, Towler DA Abstract Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once considered only a passive process of dead and dying cells, vascular calcification has now emerged as a highly regulated form of biomineralization organized by collagenous and elastin extracellular matrices. During skeletal bone formation, paracrine epithelial-mesenchymal and endothelial-mesenchymal interactions control osteochondrocytic differentiation of multipotent mesenchymal progenitor cells. These paracrine osteogenic signals, mediated by potent morphogens of the bone morphogenetic protein and wingless-type MMTV integration site family member (Wnt) superfamilies, are also active in the programming of arterial osteoprogenitor cells during... Circulation Research journals http://www.medworm.com/rss/comments.php?id=5157878 Thu, 18 Aug 2011 23:00:00 +0100 5157878