MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical And Experimental Dermatology' source. Wed, 08 Feb 2012 13:12:28 +0100 http://www.medworm.com/index.php?rid=5661228&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04189.x We describe a 48‐year‐old woman with refractory LIS, who was treated with MAL‐PDT. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661228 Thu, 02 Feb 2012 05:00:00 +0100 5661228 http://www.medworm.com/index.php?rid=5661227&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04200.x Conclusions.  The increased ceramide 1 level found in HED compared with AD is known to play a role in the structure of the lipid bilayers. However, further studies are needed to identify the functional significance of these observations and thereby elucidate differences in the skin barrier between HED and AD. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661227 Thu, 02 Feb 2012 05:00:00 +0100 5661227 http://www.medworm.com/index.php?rid=5661226&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04229.x SummaryLoss‐of‐function mutations in the gene encoding filaggrin (FLG) can cause the semidominant keratinizing disorder ichthyosis vulgaris (OMIM 146700). To identify FLG mutations in three Chinese pedigrees with ichthyosis vulgaris, we sequenced the entire coding region of FLG in the proband of each pedigree. We found two novel FLG null mutations (c.477‐478insA and c.6218‐6219delAA) and a known mutation (c.3321delA). Both novel mutations were identified in the proband of pedigree 1; c.477‐478insA was inherited from the proband’s father, and the other was a de novo mutation. Neither of these two mutations was found in 200 unrelated controls. These findings extend the spectrum of functional FLG variants possibly causing ichthyosis vulgaris. Interestingly, the proband of pedigree... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661226 Thu, 02 Feb 2012 05:00:00 +0100 5661226 http://www.medworm.com/index.php?rid=5661225&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04240.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661225 Thu, 02 Feb 2012 05:00:00 +0100 5661225 http://www.medworm.com/index.php?rid=5661224&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04255.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661224 Thu, 02 Feb 2012 05:00:00 +0100 5661224 http://www.medworm.com/index.php?rid=5661223&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04258.x Conclusions.  This study demonstrates that PCR has a higher positive and lower negative rate for detection of dermatophytes compared with KOH microscopy or culture. We suggest that PCR should be used as a complementary method for confirmation of clinically suspected dermatophytic onychomycosis. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661223 Thu, 02 Feb 2012 05:00:00 +0100 5661223 http://www.medworm.com/index.php?rid=5661222&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04259.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661222 Thu, 02 Feb 2012 05:00:00 +0100 5661222 http://www.medworm.com/index.php?rid=5661221&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04260.x SummaryHypertrophic scars resutl from abnormal healing of severe burns, and are characterized by loss of the original structure and function of the skin. Transplantation of autologous split skin is the preferred treatment after scar excision; however, there will be some unavoidable degree of contraction within the grafts. To our knowledge, it is very rare that bone marrow‐derived mesenchymal stem cells (BM‐MSCs) have been used for the treatment of skin‐graft contraction. However, in our clinics, we found that during a 2‐year follow‐up analysis, areas treated with autologous BM‐MSCs combined with transplantation of split skin were less likely to have contraction of the skin grafts than areas treated with skin grafts alone. This result indicates that BM‐MSCs may be a potential ... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661221 Thu, 02 Feb 2012 05:00:00 +0100 5661221 http://www.medworm.com/index.php?rid=5661220&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04262.x We report a 36‐year‐old woman with the interesting triad of APAD, Sjögren syndrome and IgA nephropathy. Her rashes responded to oral prednisolone and cyclophosphamide. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661220 Thu, 02 Feb 2012 05:00:00 +0100 5661220 http://www.medworm.com/index.php?rid=5661219&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04264.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661219 Thu, 02 Feb 2012 05:00:00 +0100 5661219 http://www.medworm.com/index.php?rid=5661218&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04265.x SummaryThe protein lipocalin (LCN)‐2 is known to be related to insulin resistance, obesity and atherosclerotic diseases. Psoriasis is an inflammatory skin disease related to metabolic syndrome. The aim of this study was to examine the relationship between serum LCN2 levels and indicators for metabolic syndrome and inflammatory cytokine levels in patients with psoriasis. Serum LCN2 levels were measured in patients with psoriasis, atopic dermatitis (AD) or bullous pemphigoid (BP), and compared with those of healthy controls. Serum LCN2 levels were also compared with several indicators for metabolic syndrome, and with serum levels of interleukin (IL)‐6 and tumour necrosis factor (TNF)‐α, two markers of inflammation. Serum LCN2 levels in patients with psoriasis were significantly higher... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661218 Thu, 02 Feb 2012 05:00:00 +0100 5661218 http://www.medworm.com/index.php?rid=5661217&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04272.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661217 Thu, 02 Feb 2012 05:00:00 +0100 5661217 http://www.medworm.com/index.php?rid=5661216&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04278.x SummaryKaposi sarcoma (KS) is a vascular neoplasm pathogenetically linked to human herpesvirus 8. Transplant recipients, in particular renal‐transplant recipients (RTRs) are at higher risk for post‐transplant (P)‐KS which affects 0.2–11% of RTRs. The course of P‐KS is influenced by the post‐transplantation immunosuppressive treatment. Reduction of immunosuppressive drugs can result in tumour regression, and is the treatment of choice for P‐KS, but is associated with the risk for transplant rejection. Imiquimod is a topically applied immunomodulator without relevant systemic absorption, and may thus represent a promising treatment for cutaneous KS in RTRs. The aim of this study was to investigate the clinical and histological effects of imiquimod in two RTRs with cutaneous KS.... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661216 Thu, 02 Feb 2012 05:00:00 +0100 5661216 http://www.medworm.com/index.php?rid=5661215&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04280.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661215 Thu, 02 Feb 2012 05:00:00 +0100 5661215 http://www.medworm.com/index.php?rid=5661214&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04274.x Conclusions.  LP may cause ocular surface changes and reduction in tear production, therefore it seems reasonable to evaluate these patients for symptoms and signs of dry‐eye disease. We consider that LP should be included in the differential diagnosis of dry‐eye disease, as this has important therapeutic and prognostic implications. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661214 Thu, 02 Feb 2012 05:00:00 +0100 5661214 http://www.medworm.com/index.php?rid=5661213&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04284.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661213 Thu, 02 Feb 2012 05:00:00 +0100 5661213 http://www.medworm.com/index.php?rid=5661212&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04286.x We present a case of PA as a complication of underlying psoriasis, which developed during tumour necrosis factor (TNF)‐α inhibitor therapy for Crohn disease. This paradoxical cutaneous reaction to anti‐TNF‐α threapy has been recently described as an emerging and perplexing cause of psoriasis and psoriasiform eruptions. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661212 Thu, 02 Feb 2012 05:00:00 +0100 5661212 http://www.medworm.com/index.php?rid=5661211&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04287.x We report an Indian child with ISH in whom we identified a homozygous acceptor splice site mutation, IVS2–4G>A. In silico analysis of this sequence showed that it changed predicted cryptic splicing, leading to out‐of‐frame transcripts and little, if any, functional protein. Mutations in the ANTXR2 gene can also cause juvenile hyaline fibromatosis (JHF). Although there are currently no effective treatments for ISH or JHF, identification of pathogenetic mutations in the ANTXR2 gene makes DNA‐based prenatal diagnosis feasible for subsequent pregnancies. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661211 Thu, 02 Feb 2012 05:00:00 +0100 5661211 http://www.medworm.com/index.php?rid=5661210&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04291.x Conclusion.  MB‐PDT is a cheap and efficient method of decreasing MM volume and thus disease progression. This reduction is mediated by downregulation of PCNA and heparanases. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661210 Thu, 02 Feb 2012 05:00:00 +0100 5661210 http://www.medworm.com/index.php?rid=5661209&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04292.x We report the case of a 5‐month‐old male infant who presented with slowly progressive linear atrophic skin lesions. The histological findings showed evidence of dermal hypoplasia. The child’s father had PHP‐IA. Four months after presentation, the infant developed calcifications within the pre‐existent atrophic lesions. No alterations in calcium metabolism were noted. Analysis of the GNAS gene identified a short duplication leading to a frameshift mutation. We conclude that linear atrophic skin lesions may be an early sign of imminent cutaneous calcifications in AHO. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661209 Thu, 02 Feb 2012 05:00:00 +0100 5661209 http://www.medworm.com/index.php?rid=5661208&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04296.x SummaryAn increased level of circulating nuclear antigens caused by apoptosis is thought to be responsible for the production of autoantibodies in lupus erythematosus (LE). The presentation of these antigens to immunologically competent cells may trigger systemic autoimmunity. The influence of a functional single‐nucleotide polymorphism at position −670 in the promoter of the apoptosis gene FAS on susceptibility to autoimmune diseases including systemic LE has been a controversial subject. Although it has not yet been possible to assign any particular allele or genotype to the control of FAS expression, this polymorphism has been described to be associated with several autoimmune diseases including LE. When we compared the FAS ‐670 A/G genotypes of 107 German patients with LE and tho... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5661208 Thu, 02 Feb 2012 05:00:00 +0100 5661208 http://www.medworm.com/index.php?rid=5643087&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04197.x SummaryHypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T‐cell lymphoma. To date, there have been no data published about the efficacy of a twice‐weekly regimen of narrowband ultraviolet B (NB‐UVB) for the treatment of hypopigmented MF. We retrospectively reviewed 11 patients with hypopigmented MF who were treated with NB‐UVB twice weekly between 2001 and 2010. Of the 11 patients, 7 achieved a complete response with a mean of 40 treatments; the remaining 4 patients had a partial response. Upon discontinuation of treatment, three patients had clinical relapse after complete remission. Median time to relapse was 10 months. A twice‐weekly regimen of NB‐UVB is an effective treatment for hypopigmented MF with minimal side‐effects. However, the relapse rate is ... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5643087 Wed, 25 Jan 2012 05:00:00 +0100 5643087 http://www.medworm.com/index.php?rid=5643086&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04243.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5643086 Wed, 25 Jan 2012 05:00:00 +0100 5643086 http://www.medworm.com/index.php?rid=5643085&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04256.x SummaryWhole‐body ultraviolet (UV)A1 (340–400 nm) phototherapy was first introduced 30 years ago, but is currently available in the UK in only three dermatology departments. A workshop to discuss UVA1 was held by the British Photodermatology Group in May 2009, the aim of which was to provide an overview of UVA1 phototherapy and its role in practice, and to identify areas in which further studies are required. The conclusions were that UVA1 phototherapy is an effective treatment in several inflammatory skin diseases, including localized scleroderma and atopic eczema (AE); however, deficiencies and limitations exist in the published evidence base. For most diseases, such as AE, other treatments also exist, which are generally more effective than UVA1. However, for some diseases, part... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5643085 Wed, 25 Jan 2012 05:00:00 +0100 5643085 http://www.medworm.com/index.php?rid=5643084&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04261.x Conclusion.  Skin biopsy should be considered when eruption develops after HSCT even before engraftment, especially when other organ involvement is minimal. If the first skin biopsy is inconclusive, follow‐up biopsy within a short time is helpful in the diagnosis of hyperacute GVHD. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5643084 Sun, 01 Jan 2012 05:00:00 +0100 5643084 http://www.medworm.com/index.php?rid=5579643&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04289.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5579643 Sun, 01 Jan 2012 05:00:00 +0100 5579643 http://www.medworm.com/index.php?rid=5537160&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04300_3.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537160 Sat, 24 Dec 2011 22:43:04 +0100 5537160 http://www.medworm.com/index.php?rid=5537159&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04300_2.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537159 Sat, 24 Dec 2011 22:43:02 +0100 5537159 http://www.medworm.com/index.php?rid=5537158&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04300_1.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537158 Sat, 24 Dec 2011 22:43:00 +0100 5537158 http://www.medworm.com/index.php?rid=5537157&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04299.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537157 Sat, 24 Dec 2011 22:42:58 +0100 5537157 http://www.medworm.com/index.php?rid=5537156&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04298.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537156 Sat, 24 Dec 2011 22:42:57 +0100 5537156 http://www.medworm.com/index.php?rid=5537155&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04194.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537155 Sat, 24 Dec 2011 22:42:55 +0100 5537155 http://www.medworm.com/index.php?rid=5537154&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04066.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537154 Sat, 24 Dec 2011 22:42:54 +0100 5537154 http://www.medworm.com/index.php?rid=5537153&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04067.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537153 Sat, 24 Dec 2011 22:42:52 +0100 5537153 http://www.medworm.com/index.php?rid=5537152&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04072.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537152 Sat, 24 Dec 2011 22:42:50 +0100 5537152 http://www.medworm.com/index.php?rid=5537151&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04110.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537151 Sat, 24 Dec 2011 22:42:41 +0100 5537151 http://www.medworm.com/index.php?rid=5537150&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04109.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537150 Sat, 24 Dec 2011 22:42:40 +0100 5537150 http://www.medworm.com/index.php?rid=5537149&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04142.x SummaryFew studies have investigated the role of vitamin B12 metabolism in vitiligo. We tested the hypothesis that vitamin B12 and folate metabolism might have an influence on the pathogenesis of vitiligo. Full blood count and levels of folic acid, vitamin B12, homocysteine and holotranscobalamine were examined for 69 patients with vitiligo and 52 controls. The vitiligo group had higher levels of homocysteine (P < 0.01) and haemoglobin (P < 0.01) levels, and lower levels of vitamin B12 (P < 0.01) and holotranscobalamine (P < 0.0001) than the control group. Folic acid levels were similar for both groups. In a risk analysis, hyperhomocysteinaemia (≥ 15 μmol/L, P < 0.01) and vitamin B12 deficiency (< 200 pg/mL, P < 0.01) were significant r... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537149 Sat, 24 Dec 2011 22:42:35 +0100 5537149 http://www.medworm.com/index.php?rid=5537148&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04199.x Conclusions.  The data confirm the efficacy of all three treatments, with the most effective scar treatment being the fat grafts mixed with PRP, followed by skin resurfacing with nonablative laser. This combined treatment appeared to be safe and effective for scar treatment. Further studies are needed to explore the potential use of this combined treatment. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537148 Sat, 24 Dec 2011 22:42:33 +0100 5537148 http://www.medworm.com/index.php?rid=5537147&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04201.x Conclusion.  In this BLM‐induced dermal fibrosis model, MMF and DCZ treatments prevented the development of dermal fibrosis. Further studies are needed to evaluate whether targeting T lymphocytes is effective in resolving pre‐existing fibrosis in human scleroderma. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537147 Sat, 24 Dec 2011 22:42:32 +0100 5537147 http://www.medworm.com/index.php?rid=5537146&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04153.x In conclusion, this is a novel mutation in the ECM1 gene, which is the underlying cause of LP in this patient. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537146 Sat, 24 Dec 2011 22:42:26 +0100 5537146 http://www.medworm.com/index.php?rid=5537145&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04202.x Conclusions.  Skin disorders in this population were very common, and the disorders identified were those that commonly affect children without HIV in Ethiopia. However, MC and plane warts appeared to have a higher frequency than would be expected in uninfected children. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537145 Sat, 24 Dec 2011 22:42:21 +0100 5537145 http://www.medworm.com/index.php?rid=5537139&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04257.x We report the case of a middle‐aged patient with botryomycosis presenting as nasal cutaneous fistulas caused by P. melaninogenica, which was successfully treated with surgical intervention combined with systemic antibiotic treatment. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537139 Sat, 24 Dec 2011 22:42:05 +0100 5537139 http://www.medworm.com/index.php?rid=5537141&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04246.x Conclusions.  The reported incidence of BCC in those aged < 30 years has increased by 145% during this period, corresponding to an average annual increase of 8.53%. This may be partially due to earlier presentation and to increased use of surgical treatments. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537141 Fri, 23 Dec 2011 05:00:00 +0100 5537141 http://www.medworm.com/index.php?rid=5537140&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04253.x Conclusions.  Prophylactic administration of EGb‐761 seems to have a protective effect against radiation‐induced dermatitis. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537140 Fri, 23 Dec 2011 05:00:00 +0100 5537140 http://www.medworm.com/index.php?rid=5537144&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04213.x Conclusion.  SlanDCs, initially described as large population of proinflammatory DCs in blood, are a novel and major part of the resident dermal myeloid DC system in both healthy and inflamed skin. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537144 Tue, 20 Dec 2011 05:00:00 +0100 5537144 http://www.medworm.com/index.php?rid=5537143&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04225.x Conclusions.  We have identified a correlation between two exon 7 mutations of the CDC2L1 gene and keloid disease. A further study of protein‐kinase activity should be conducted to confirm the functionality of the CDC2L1 gene in the prevention of scar formation. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537143 Tue, 20 Dec 2011 05:00:00 +0100 5537143 http://www.medworm.com/index.php?rid=5537142&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04227.x Conclusions.  We have identified an immunogenic region of Der p 2 presented by common HLA class II alleles, including the most commonly expressed HLA allele DPB1*0401. Identification of such epitopes may be of future value in peptide immunotherapeutic approaches. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5537142 Tue, 20 Dec 2011 05:00:00 +0100 5537142 http://www.medworm.com/index.php?rid=5443619&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04203.x SummaryA 90‐year‐old man presented with a rapidly growing vascular lesion after a pacemaker generator change. The rapid growth suggested a possible angiosarcoma. A less dramatic presentation of vascular proliferation has been described as reticular telangiectatic erythema, which has been reporting following insertion of pacemakers, implantable cardioverter defibrillators, and drug‐delivery devices. The onset of the disorder is described as weeks to years after implantation or generator change. It is a benign condition that generally remains static or regresses over time. The vascular proliferation noted in this case resolved almost completely over a period of 1 year. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5443619 Fri, 25 Nov 2011 18:18:05 +0100 5443619 http://www.medworm.com/index.php?rid=5426089&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04250_2.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426089 Sat, 19 Nov 2011 22:25:04 +0100 5426089 http://www.medworm.com/index.php?rid=5426088&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04250_1.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426088 Sat, 19 Nov 2011 22:25:03 +0100 5426088 http://www.medworm.com/index.php?rid=5426087&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04252.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426087 Sat, 19 Nov 2011 22:25:01 +0100 5426087 http://www.medworm.com/index.php?rid=5426086&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04251.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426086 Sat, 19 Nov 2011 22:25:00 +0100 5426086 http://www.medworm.com/index.php?rid=5426085&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04068.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426085 Sat, 19 Nov 2011 22:24:58 +0100 5426085 http://www.medworm.com/index.php?rid=5426084&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04070.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426084 Sat, 19 Nov 2011 22:24:57 +0100 5426084 http://www.medworm.com/index.php?rid=5426083&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04052.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426083 Sat, 19 Nov 2011 22:24:55 +0100 5426083 http://www.medworm.com/index.php?rid=5426082&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04096.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426082 Sat, 19 Nov 2011 22:24:54 +0100 5426082 http://www.medworm.com/index.php?rid=5426081&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04094.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426081 Sat, 19 Nov 2011 22:24:51 +0100 5426081 http://www.medworm.com/index.php?rid=5426080&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04095.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426080 Sat, 19 Nov 2011 22:24:49 +0100 5426080 http://www.medworm.com/index.php?rid=5426079&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04098.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426079 Sat, 19 Nov 2011 22:24:48 +0100 5426079 http://www.medworm.com/index.php?rid=5426078&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04107.x We report a case of focal APKH occurring in an adult woman. This was associated with a previously unreported feature, that of eyelash involvement. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426078 Sat, 19 Nov 2011 22:24:37 +0100 5426078 http://www.medworm.com/index.php?rid=5426077&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04102.x We present two cases of BP, one triggered by intravenous iodine, and one associated with etanercept treatment in a patient with psoriasis; the first time, to our knowledge, that either of these associations has been reported. The recognition of occasional cases of drug‐induced BP such as ours, with timely cessation of the offending agent, may produce rapid clinical improvement with decreased exposure to potent immunosuppressive therapy. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426077 Sat, 19 Nov 2011 22:24:33 +0100 5426077 http://www.medworm.com/index.php?rid=5426076&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04218.x SummaryThis review summarizes important clinical developments in acne treatment identified in five systematic reviews and two significant primary research studies, published between March 2010 and February 2011. Although evidence showing a direct link between development of bacterial resistance and oral antibiotic therapy for acne is not convincing, prescribers can still tailor their practice to minimize future risks by stopping treatment when appropriate, using benzoyl peroxide, and avoiding combining topical and systemic antimicrobials. A systematic review evaluating combination products containing benzoyl peroxide did not show convincing evidence that such products are superior to monotherapies. A systematic review of combined oral contraceptives confirmed their efficacy for acne in wom... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426076 Sat, 19 Nov 2011 22:24:25 +0100 5426076 http://www.medworm.com/index.php?rid=5426075&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04162.x SummaryThe dyschromatoses are a group of pigmentary disorders characterized clinically by mixed and often guttate hypopigmented and hyperpigmented lesions. There are many conditions that present with dyschromatosis, including genodermatoses, inflammatory skin diseases, infections, drug and chemical use, and nutritional disorders. Some conditions have extracutaneous features. Poikiloderma (a combination of hypo‐ and hyperpigmentation with telangiectasia and atrophy) must be excluded. In this article, we describe the dyschromatoses typically presenting in infancy and childhood, most of which are genodermatoses. The approach we have taken in classifying them is based on organ involvement. We hope this article will serve as a guide for dermatologists to the recognition of these uncommon cond... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426075 Sat, 19 Nov 2011 22:24:24 +0100 5426075 http://www.medworm.com/index.php?rid=5426073&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04141.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426073 Sat, 19 Nov 2011 22:24:04 +0100 5426073 http://www.medworm.com/index.php?rid=5426074&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04209.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5426074 Tue, 18 Oct 2011 04:00:00 +0100 5426074 http://www.medworm.com/index.php?rid=5331783&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04161.x SummaryThe dyschromatoses are a group of pigmentary disorders characterized clinically by mixed and often guttate hypopigmentend and hyperpigmented lesions. There are many conditions that present with dyschromatosis, including genodermatoses, inflammatory skin diseases, infections, drug and chemical use, and nutritional disorders. Some conditions have extracutaneous features. In this article, we describe the dyschromatoses with typical onset in adulthood. Most diseases in this group are acquired conditions. To organize the various acquired dyschromatoses, we have categorized them into those with a history of chemical exposure, drug exposure or dermatological procedures, and those without a history of such exposure. In contrast to the genetic dyschromatoses, some acquired dyschromatoses are... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331783 Tue, 18 Oct 2011 04:00:00 +0100 5331783 http://www.medworm.com/index.php?rid=5331782&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04169.x We report our experience of using thalidomide over the past 10 years in patients referred within our region with severe refractory aphthous ulceration, and their response to treatment and side‐effects. In our experience, thalidomide works well for severe refractory aphthous ulceration, with a typical patient response reported within 4 weeks, but its use is limited by neurotoxicity. The aphthous ulceration occurring in the context of BD was more difficult to control than idiopathic aphthous ulceration. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331782 Tue, 18 Oct 2011 04:00:00 +0100 5331782 http://www.medworm.com/index.php?rid=5331781&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04173.x SummaryDuring pregnancy, the mother undergoes changes to sustain and enable normal growth and development of the fetus. Common physiological changes include linea nigra, fibroepithelial polyps, striae, spider angioma, palmar erythema and pruritis gravidarum. However, there are some changes that are purely pathological, and these are termed the pregnancy‐specific dermatoses (PSDs). The PSDs occur during pregnancy or in the immediate postpartum period. They do not include the various benign conditions or pre‐existing dermatoses and tumours that may present or worsen with pregnancy. They do include a number of distinct and identifiable conditions: atopic eruption of pregnancy (AEP), polymorphic eruption of pregnancy (PEP), intrahepatic cholestasis of pregnancy (ICP) and pemphigoid gestati... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331781 Tue, 18 Oct 2011 04:00:00 +0100 5331781 http://www.medworm.com/index.php?rid=5331780&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04174.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331780 Tue, 18 Oct 2011 04:00:00 +0100 5331780 http://www.medworm.com/index.php?rid=5331779&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04175.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331779 Tue, 18 Oct 2011 04:00:00 +0100 5331779 http://www.medworm.com/index.php?rid=5331778&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04176.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331778 Tue, 18 Oct 2011 04:00:00 +0100 5331778 http://www.medworm.com/index.php?rid=5331777&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04179.x Conclusions.  These cases show that RDEB‐GO is not an absolute primary indication for elective caesarean section and that, perhaps surprisingly, genital/perineal blistering and scarring are not inevitable consequences of childbirth. Moreover, breastfeeding is also feasible in women with RDEB‐GO. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331777 Tue, 18 Oct 2011 04:00:00 +0100 5331777 http://www.medworm.com/index.php?rid=5331776&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04181.x We present a detailed description of the patient and discuss the mechanisms of GCAP, and suggest that GCAP may be useful for treating RD. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331776 Tue, 18 Oct 2011 04:00:00 +0100 5331776 http://www.medworm.com/index.php?rid=5331775&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04198.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331775 Tue, 18 Oct 2011 04:00:00 +0100 5331775 http://www.medworm.com/index.php?rid=5331774&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04204.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331774 Tue, 18 Oct 2011 04:00:00 +0100 5331774 http://www.medworm.com/index.php?rid=5331773&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04208.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331773 Tue, 18 Oct 2011 04:00:00 +0100 5331773 http://www.medworm.com/index.php?rid=5331784&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04195.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5331784 Thu, 13 Oct 2011 04:00:00 +0100 5331784 http://www.medworm.com/index.php?rid=5315165&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04164.x SummaryChanarin–Dorfman syndrome (CDS) is an autosomal recessive metabolic disorder characterized by congenital ichthyosis and visceral complications due to accumulation of neutral lipids. CDS is caused by mutations in the ABHD5 (previously termed CGI‐58) gene. In the present study, we assessed a young child presenting with ichthyosis and hepatomegaly, suggesting a diagnosis of CDS. We identified an intronic mutation, c.960 + 5G>A, which was found to result in skipping of exon 6. Abnormal results on liver function tests led us to treat the child with acitretin, which resulted in satisfactory clinical and laboratory responses. The present case illustrates the beneficial effect of acitretin treatment in CDS even in the presence of compromised liver function. (Source: Clinical And ... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5315165 Mon, 10 Oct 2011 04:00:00 +0100 5315165 http://www.medworm.com/index.php?rid=5315163&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04165.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5315163 Mon, 10 Oct 2011 04:00:00 +0100 5315163 http://www.medworm.com/index.php?rid=5315161&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04177.x We report the first case, to our knowledge, of the simultaneous occurrence of cutaneous vasculitis and nephrotic syndrome in a 65‐year‐old woman with IgA nephropathy after a B. henselae infection transmitted by a cat scratch. The aetiopathogenetic role of B. henselae was hypothesized on the basis of the serological demonstration of acute B. henselae infection, the immunofluorescence findings, and the prompt resolution after azithromycin treatment. Patients reporting cat scratches or bites should undergo accurate clinical examination, routine laboratory examinations, urinalysis and clinical surveillance. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5315161 Mon, 10 Oct 2011 04:00:00 +0100 5315161 http://www.medworm.com/index.php?rid=5315159&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04184.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5315159 Mon, 10 Oct 2011 04:00:00 +0100 5315159 http://www.medworm.com/index.php?rid=5315157&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04186.x Conclusion.  Our meta‐analysis suggests that the G allele of AR StuI polymorphism might be a potential risk factor for AGA, especially in white populations. However, we did not find any obvious association of the CAG and GGC triplet‐repeat polymorphisms of the AR gene with risk for AGA. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5315157 Mon, 10 Oct 2011 04:00:00 +0100 5315157 http://www.medworm.com/index.php?rid=5315156&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04187.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5315156 Mon, 10 Oct 2011 04:00:00 +0100 5315156 http://www.medworm.com/index.php?rid=5315155&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04188.x SummaryA limited number of case series has indicated that methotrexate (MTX) might be a useful drug in the treatment of dermatomyositis (DM), a rare autoimmune disease involving the skin and muscles. However, these earlier studies mainly focused on the efficacy of MTX on DM muscular symptoms. To analyse the efficacy of MTX on skin lesions in DM, the records of 34 patients with DM seen between 2004 and 2009 were retrospectively analysed, and the DM skin disease activity at different time points was determined, with specific focus on cutaneous features using the validated Cutaneous Dermatomyositis Activity Index (CDASI) score. The lesional inflammation was scored in primary skin biopsies. Additionally, we performed a systematic review of the available literature. In our series, 11 patien... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5315155 Mon, 10 Oct 2011 04:00:00 +0100 5315155 http://www.medworm.com/index.php?rid=5301079&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04150.x Conclusion.  Combined 1064 QNYL and GA seems to be superior to 1064 QNYL alone in the treatment of mixed‐type melasma. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5301079 Wed, 05 Oct 2011 04:00:00 +0100 5301079 http://www.medworm.com/index.php?rid=5301078&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04167.x We report an unusual case, in which eccrine porocarcinoma arose at the exact site of pre‐existing Bowen disease (BD). (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5301078 Wed, 05 Oct 2011 04:00:00 +0100 5301078 http://www.medworm.com/index.php?rid=5301077&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04148.x Conclusions.  The NNT of 6.3 in this study compares favourably with NNT ratios from studies of dermatologists from other countries. This study may encourage other countries and individual doctors to assess their NNT ratios, as it may be an important indicator of the efficient use of resources and the avoidance of unnecessary surgery for patients. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5301077 Sat, 01 Oct 2011 04:00:00 +0100 5301077 http://www.medworm.com/index.php?rid=5282914&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04205.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5282914 Sat, 01 Oct 2011 04:00:00 +0100 5282914 http://www.medworm.com/index.php?rid=5249572&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04193.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249572 Sat, 24 Sep 2011 14:05:26 +0100 5249572 http://www.medworm.com/index.php?rid=5249571&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04192_3.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249571 Sat, 24 Sep 2011 14:05:24 +0100 5249571 http://www.medworm.com/index.php?rid=5249570&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04192_2.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249570 Sat, 24 Sep 2011 14:05:22 +0100 5249570 http://www.medworm.com/index.php?rid=5249569&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04192_1.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249569 Sat, 24 Sep 2011 14:05:20 +0100 5249569 http://www.medworm.com/index.php?rid=5249568&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04191.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249568 Sat, 24 Sep 2011 14:05:18 +0100 5249568 http://www.medworm.com/index.php?rid=5249567&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04190.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249567 Sat, 24 Sep 2011 14:05:17 +0100 5249567 http://www.medworm.com/index.php?rid=5249566&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04063.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249566 Sat, 24 Sep 2011 14:05:15 +0100 5249566 http://www.medworm.com/index.php?rid=5249565&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04040.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249565 Sat, 24 Sep 2011 14:05:13 +0100 5249565 http://www.medworm.com/index.php?rid=5249564&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04054.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249564 Sat, 24 Sep 2011 14:05:11 +0100 5249564 http://www.medworm.com/index.php?rid=5249563&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04051.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249563 Sat, 24 Sep 2011 14:05:09 +0100 5249563 http://www.medworm.com/index.php?rid=5249562&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04097.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249562 Sat, 24 Sep 2011 14:05:07 +0100 5249562 http://www.medworm.com/index.php?rid=5249561&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04089.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249561 Sat, 24 Sep 2011 14:05:05 +0100 5249561 http://www.medworm.com/index.php?rid=5249560&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04083.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249560 Sat, 24 Sep 2011 14:05:01 +0100 5249560 http://www.medworm.com/index.php?rid=5249559&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04044.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249559 Sat, 24 Sep 2011 14:04:52 +0100 5249559 http://www.medworm.com/index.php?rid=5249558&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04045.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249558 Sat, 24 Sep 2011 14:04:50 +0100 5249558 http://www.medworm.com/index.php?rid=5249557&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04046.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249557 Sat, 24 Sep 2011 14:04:48 +0100 5249557 http://www.medworm.com/index.php?rid=5249556&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04058.x In this study, we performed mutation detection of the ADAR1 gene in two Chinese families with DSH. PCR and direct sequencing of the ADAR1 gene were used to identify and confirm the mutations in the two families. Furthermore, we analysed the RNA transcripts by reverse transcriptase (RT)‐PCR. Two aberrant splice products were confirmed with RT‐PCR and DNA direct sequence analysis. These novel findings further extend our understanding of the role of ADAR1 in DSH. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249556 Sat, 24 Sep 2011 14:04:46 +0100 5249556 http://www.medworm.com/index.php?rid=5249555&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04069.x Conclusions.  Based on these results, we suggest that RUNX3 has an oncogenic potential and does not act as a tumour suppressor in skin cancers. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249555 Sat, 24 Sep 2011 14:04:37 +0100 5249555 http://www.medworm.com/index.php?rid=5249554&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04101.x In conclusion, we report a case of a rare inherited immunodeficiency, CGD, in a 61‐year‐old man, and describe the novel hemizygous missense mutation underlying the condition. Mild forms of usually fatal immunodeficiencies should be considered when assessing the occurrence of unusual infectious diseases in apparently healthy people. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249554 Sat, 24 Sep 2011 14:04:32 +0100 5249554 http://www.medworm.com/index.php?rid=5249553&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04093.x We report a case of fixed drug eruption (FDE) caused by three unrelated drugs. A 52‐year‐old woman presented with a diagnosis of FDE after taking a drug to treat a common cold. An oral provocation test and a patch test were carried out, and the patient reacted to promethazine, which is a derivative of phenothiazine. To determine the core structure of the antigen, we performed patch testing and/or an oral provocation testing with six drugs that are similar in structure to promethazine. The patient reacted to five of the six drugs, and the antigenic determinant was identified as a phenothiazine and a tricyclic structure. The patient had similar eruptions at the same sites 3 years later after taking pethidine. Seven months after that reaction, a more severe eruption was caused by oral o... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249553 Sat, 24 Sep 2011 14:04:30 +0100 5249553 http://www.medworm.com/index.php?rid=5249552&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04081.x We report a 16‐year‐old girl with the typical findings of PNP associated with Castleman’s tumour. She was treated with tumour resection in combination with plasmapheresis and corticosteroids. Fifteen months after the operation, the patient had recovered without the development of BO. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249552 Sat, 24 Sep 2011 14:04:28 +0100 5249552 http://www.medworm.com/index.php?rid=5249551&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04086.x We report three cases of DI with inanimate materials, and examine ‘Morgellons’ disease. We believe that patients with unusual presentations of DI are likely to be seen more commonly in the future. These patients appear to be a subgroup of DI, and may be even more difficult to treat than other patients with DI. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249551 Sat, 24 Sep 2011 14:04:24 +0100 5249551 http://www.medworm.com/index.php?rid=5249550&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04082.x Conclusions.  In the majority of cases of initially negative examinations, consecutive laboratory fungal tests will eventually produce positive results. These findings suggest that systemic antifungal treatment should be started in patients with suspected fungal infections, even if they have negative laboratory fungal examinations. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249550 Sat, 24 Sep 2011 14:04:16 +0100 5249550 http://www.medworm.com/index.php?rid=5249548&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04172.x Conclusions.  These data suggest that the failure of LCs to migrate in response to stimulation in patients with psoriasis is not attributable to a systemic defect in DC function, but is rather a reflection of local changes in the epidermal microenvironment. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249548 Sat, 24 Sep 2011 14:04:05 +0100 5249548 http://www.medworm.com/index.php?rid=5249549&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04154.x Conclusion.  If only a single biopsy specimen is available, it may be preferable to have transverse sections in cases of suspected noncicatricial alopecia, and vertical sections in cases of suspected lichen planopilaris. Either type of sectioning is suitable for cicatricial alopecia when lichen planopilaris is clinically unlikely. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5249549 Thu, 15 Sep 2011 04:00:00 +0100 5249549 http://www.medworm.com/index.php?rid=5220774&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04092.x Summary  Pemphigus vulgaris (PV) is a severe autoimmune bullous disease involving both the skin and mucosal areas, and characterized by intraepithelial flaccid blisters and erosions. The pathogenesis of this disease is not yet completely understood, but novel insights into desmoglein biology and autoantibody pathogenesis have recently been published. Acantholysis in PV seems to result from a collective action of autoantibodies against various keratinocyte self antigens, of which desmogleins 1 and 3 are the most important. Additional antigens including desmocollins and nondesmosome components, such as the mitochondrion, might take part in disease activation. Recently, apoptosis was reported as a possible underlying mechanism of acantholysis. Furthermore, apoptolysis is believed to be the ... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5220774 Fri, 09 Sep 2011 04:00:00 +0100 5220774 http://www.medworm.com/index.php?rid=5160088&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04076.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160088 Wed, 24 Aug 2011 23:00:00 +0100 5160088 http://www.medworm.com/index.php?rid=5160087&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04085.x SummaryAn 80‐year‐old man presented with a 6‐month history of indurated tender purple papules. These had coalesced to form plaques with some central scarring and a dermatomal distribution on the left arm, immediately following herpes zoster (HZ) infection at this site. The patient had a 5‐year history of small lymphocytic lymphoma (SLL), which was being managed conservatively under a ‘watch and wait’ protocol. On histological examination of a skin biopsy, marked interstitial granulomas and prominent granulomatous vasculitis were seen, supporting the clinical impression of a post‐HZ granulomatous reaction. In addition, there was a dense monoclonal small B‐cell lymphocytic infiltrate indicating koebnerization by SLL (a finding that has not been reported previously with concur... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160087 Wed, 24 Aug 2011 23:00:00 +0100 5160087 http://www.medworm.com/index.php?rid=5160086&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04090.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160086 Wed, 24 Aug 2011 23:00:00 +0100 5160086 http://www.medworm.com/index.php?rid=5160085&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04114.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160085 Wed, 24 Aug 2011 23:00:00 +0100 5160085 http://www.medworm.com/index.php?rid=5160084&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04115.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160084 Wed, 24 Aug 2011 23:00:00 +0100 5160084 http://www.medworm.com/index.php?rid=5160083&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04118.x Conclusion.  p50 and cortactin might be useful makers to distinguish between KA and well‐differentiated SCC. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160083 Wed, 24 Aug 2011 23:00:00 +0100 5160083 http://www.medworm.com/index.php?rid=5160082&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04147.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160082 Wed, 24 Aug 2011 23:00:00 +0100 5160082 http://www.medworm.com/index.php?rid=5160081&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04149.x In this study, a 2.5‐kJ/m2 dose of UVB radiation was delivered by a sunlamp to the ear or the eye of wild‐type C57BL/6j mice and of gp91 phox−/− C57BL/6j mice that had a knockout mutation of the gp91 phox subunit of reduced nicotinamide adenine dinucleotide phosphate oxidase (NADPH). The degree of change in the Dopa‐positive melanocyte expression in was reduced in gp91 phox−/− mice given UVB irradiation to the eye, but not in those given irradiation to the ear. The plasma level of α‐melanocyte‐stimulating hormone (α‐MSH) in the blood increased in the C57BL/6j mice after irradiation to either the eye or the ear, but it did not increase in the gp91 phox−/− mice given UVB irradiation to the eye. Both gp91 phox and α‐MSH in the central nervous system seem to contri... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160081 Wed, 24 Aug 2011 23:00:00 +0100 5160081 http://www.medworm.com/index.php?rid=5160080&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04151.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160080 Wed, 24 Aug 2011 23:00:00 +0100 5160080 http://www.medworm.com/index.php?rid=5160079&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04152.x Conclusions.  Lower serum levels of vitamin C in patients with LP indicates that free radicals and the resulting oxidative damage may be important in the pathogenesis of LP lesions. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160079 Wed, 24 Aug 2011 23:00:00 +0100 5160079 http://www.medworm.com/index.php?rid=5160078&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04155.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160078 Wed, 24 Aug 2011 23:00:00 +0100 5160078 http://www.medworm.com/index.php?rid=5160077&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04157.x SummaryMicrosporum canis is a common zoophilic dermatophyte, which causes a range of infections. To explore the pathogenic mechanism of tinea capitis, we used the suppression subtractive hybridization (SSH) technique to investigate the differences in gene expression between different cultures of Microsporum canis incubated on three different types of mineral media containing child glabrous skin, child scalp tissue and adult scalp tissue. Using dot‐blot hybridization and real‐time PCR technique, we successfully screened and identified a pair of genes that had expression levels 44.6 and 117 times higher in culture 1 (M. canis cultured in mineral medium with child scalp tissue) than in culture 2 (M. canis cultured in mineral medium with glabrous skin tissue), and another pair of genes w... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160077 Wed, 24 Aug 2011 23:00:00 +0100 5160077 http://www.medworm.com/index.php?rid=5160076&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04158.x Conclusions.  Our data indicate that serum levels of miR‐142‐3p may be elevated specifically in patients with SSc, correlating with the severity of this disease, and may be useful diagnostic markers for the presence of SSc and for the differentiation of SSc from SSD. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160076 Wed, 24 Aug 2011 23:00:00 +0100 5160076 http://www.medworm.com/index.php?rid=5160075&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04159.x Conclusion.  Immune reactions mediated by granulysin‐positive CTLs may play an important role in the pathogenesis of acne‐like eruptions, oral ulcers and genital ulcers in BD. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160075 Wed, 24 Aug 2011 23:00:00 +0100 5160075 http://www.medworm.com/index.php?rid=5160074&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04160.x SummaryA 47‐year‐old‐man presented with rashes on his trunk and limbs, and a diagnosis of parapsoriasis was made. Ten years later, the rashes had progressed gradually to form plaques and tumours. Gene rearrangement studies revealed monoclonality of the T‐cell receptor β‐chain (TCR‐Jβ)1 gene, and results of flow cytometry and immunohistochemical examination confirmed a diagnosis of epidermotropic CD8+ cytotoxic T‐cell lymphoma. The clinical course of the disease remained indolent for some time, but about 2 years later, neutrophilic pustules formed on the surface of the skin lesions, and tumours developed in the patient’s testes. Using flow cytometry, emergence of CD7+ cells was found. The patient died the following year of respiratory failure due to brain herniation. On ... Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5160074 Sun, 31 Jul 2011 23:00:00 +0100 5160074 http://www.medworm.com/index.php?rid=5063827&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04146_3.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063827 Tue, 26 Jul 2011 16:31:21 +0100 5063827 http://www.medworm.com/index.php?rid=5063826&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04146_2.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063826 Tue, 26 Jul 2011 16:31:20 +0100 5063826 http://www.medworm.com/index.php?rid=5063825&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04146_1.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063825 Tue, 26 Jul 2011 16:31:20 +0100 5063825 http://www.medworm.com/index.php?rid=5063824&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04145.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063824 Tue, 26 Jul 2011 16:31:19 +0100 5063824 http://www.medworm.com/index.php?rid=5063823&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04144.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063823 Tue, 26 Jul 2011 16:31:19 +0100 5063823 http://www.medworm.com/index.php?rid=5063822&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04022.x SummaryRobert Willan is commemorated by a blue plaque on the house in which he lived in Bloomsbury Square in London. He lived there during a productive period of his career, until ill‐health caused him to travel to Madeira, where he died. This fitting tribute to Willan is the result of the efforts of Dr Henry MacCormac, himself an eminent British dermatologist of the first half of the 20th century. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063822 Tue, 26 Jul 2011 16:31:18 +0100 5063822 http://www.medworm.com/index.php?rid=5063821&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04027.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063821 Tue, 26 Jul 2011 16:31:17 +0100 5063821 http://www.medworm.com/index.php?rid=5063820&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2010.04003.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063820 Tue, 26 Jul 2011 16:31:17 +0100 5063820 http://www.medworm.com/index.php?rid=5063819&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04021.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063819 Tue, 26 Jul 2011 16:31:16 +0100 5063819 http://www.medworm.com/index.php?rid=5063818&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04017.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063818 Tue, 26 Jul 2011 16:31:15 +0100 5063818 http://www.medworm.com/index.php?rid=5063817&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2010.03990.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063817 Tue, 26 Jul 2011 16:31:15 +0100 5063817 http://www.medworm.com/index.php?rid=5063816&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2010.03995.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063816 Tue, 26 Jul 2011 16:31:14 +0100 5063816 http://www.medworm.com/index.php?rid=5063815&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04042.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063815 Tue, 26 Jul 2011 16:31:12 +0100 5063815 http://www.medworm.com/index.php?rid=5063814&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04020.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063814 Tue, 26 Jul 2011 16:31:11 +0100 5063814 http://www.medworm.com/index.php?rid=5063813&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2010.04000.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063813 Tue, 26 Jul 2011 16:31:11 +0100 5063813 http://www.medworm.com/index.php?rid=5063812&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2010.03998.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063812 Tue, 26 Jul 2011 16:31:10 +0100 5063812 http://www.medworm.com/index.php?rid=5063811&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2010.03992.x (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063811 Tue, 26 Jul 2011 16:31:09 +0100 5063811 http://www.medworm.com/index.php?rid=5063810&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04103.x SummaryIrradiation by ultraviolet (UV) A is known to decrease Langerhans cells (LCs) in the skin and increase IgA expression in the intestine, specifically the jejunum. These changes were induced in C57BL/6j mice by exposure of the ear or the eyes to 11 J/cm2 UVA radiation, then a melanocortin receptor agonist (Agouti‐related protein; AgRP) was introduced either intracerebrally or intracerebroventricularly. The degree of change in both LC number and IgA expression induced by UVA eye irradiation was reduced more by intracerebral than by intraperitoneal injection of AgRP. α‐Melanocyte‐stimulating hormone and melanocortin receptors in the brain seem to contribute to immunomodulation after UVA irradiation of the eye or the ear in mice. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063810 Tue, 26 Jul 2011 16:31:08 +0100 5063810 http://www.medworm.com/index.php?rid=5063809&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2010.03989.x Conclusion.  After topical application, Pc 4 is absorbed into the epidermis in as little as 1 h, and the absorption increased with increasing time and dose. Pc 4 can be effectively delivered into human skin via topical application. The data also suggest that the degree of penetration is time‐ and dose‐dependent. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063809 Tue, 26 Jul 2011 16:31:04 +0100 5063809 http://www.medworm.com/index.php?rid=5063808&cid=s_38064_12_f&fid=38064&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2230.2011.04039.x We report a case of recalcitrant cutaneous warts that resolved with intravenous cidofovir treatment. The patient was immunocompromised secondary to monoclonal antibody therapy for psoriasis. (Source: Clinical And Experimental Dermatology) Clinical And Experimental Dermatology journals http://www.medworm.com/rss/comments.php?id=5063808 Tue, 26 Jul 2011 16:31:02 +0100 5063808