Clinical Chemistry via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Chemistry' source. Thu, 09 Feb 2012 13:01:33 +0100 American Old Master: The Art and Science of Thomas Eakins [Science in the Arts] http://www.medworm.com/index.php?rid=5643310&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F480%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643310 Sat, 28 Jan 2012 05:00:00 +0100 5643310 Diary [Unveiling the Right Side] http://www.medworm.com/index.php?rid=5643309&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F479%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643309 Sat, 28 Jan 2012 05:00:00 +0100 5643309 Sinusitis or Something Worse? [What is your Guess?] http://www.medworm.com/index.php?rid=5643308&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F477%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643308 Sat, 28 Jan 2012 05:00:00 +0100 5643308 Correction [Correction] http://www.medworm.com/index.php?rid=5643307&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F476%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643307 Sat, 28 Jan 2012 05:00:00 +0100 5643307 In Reply [Letters to the Editor] http://www.medworm.com/index.php?rid=5643306&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F474%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643306 Sat, 28 Jan 2012 05:00:00 +0100 5643306 Do Platform-Specific Factors Explain MicroRNA Profiling Disparities? [Letters to the Editor] http://www.medworm.com/index.php?rid=5643305&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F472%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643305 Sat, 28 Jan 2012 05:00:00 +0100 5643305 Impact of the Introduction of Guidelines on Vitamin B12 Testing [Letters to the Editor] http://www.medworm.com/index.php?rid=5643304&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F471%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643304 Sat, 28 Jan 2012 05:00:00 +0100 5643304 Brain Natriuretic Peptide and Breathing Not Properly: The Merger of 2 BNPs [Citation Classic] http://www.medworm.com/index.php?rid=5643303&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F469%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643303 Sat, 28 Jan 2012 05:00:00 +0100 5643303 Further Improvement in Quantifying Male Fetal DNA in Maternal Plasma [Brief Communication] http://www.medworm.com/index.php?rid=5643302&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F465%3Frss%3D1 CONCLUSIONS: The YRS assay is a substantial improvement for quantifying rare male fetal DNA in maternal plasma. The higher sensitivity and specificity may expand the clinical and research utility of cffDNA. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643302 Sat, 28 Jan 2012 05:00:00 +0100 5643302 Comparison of Serum Creatinine and Cystatin C for Early Diagnosis of Contrast-Induced Nephropathy after Coronary Angiography and Interventions [Evidence-Based Medicine and Test Utilization] http://www.medworm.com/index.php?rid=5643301&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F458%3Frss%3D1 CONCLUSIONS: Variations from the serum creatinine baseline offer better diagnostic accuracy for predicting CIN at an earlier stage than similar variations in Cys. An additional diagnostic value of Cys over the determination of serum creatinine in the setting of CIN was not observed. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643301 Sat, 28 Jan 2012 05:00:00 +0100 5643301 Estimating Glomerular Filtration Rates by Use of Both Cystatin C and Standardized Serum Creatinine Avoids Ethnicity Coefficients in Asian Patients with Chronic Kidney Disease [Evidence-Based Medicine and Test Utilization] http://www.medworm.com/index.php?rid=5643300&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F450%3Frss%3D1 CONCLUSIONS: The use of a cystatin C and creatinine combination equation for estimating GFR in a multiethnic Asian population with CKD does not require ethnicity coefficients because the derived coefficients are very close to each other. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643300 Sat, 28 Jan 2012 05:00:00 +0100 5643300 Growth Differentiation Factor-15 in the Early Diagnosis and Risk Stratification of Patients with Acute Chest Pain [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5643299&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F441%3Frss%3D1 CONCLUSIONS: GDF-15 predicts all-cause mortality in unselected patients with acute chest pain independently of and more accurately than hs-cTnT and BNP. However, GDF-15 does not seem to help in the early diagnosis of AMI. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643299 Sat, 28 Jan 2012 05:00:00 +0100 5643299 Exhaled Endogenous Particles Contain Lung Proteins [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5643298&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F431%3Frss%3D1 CONCLUSIONS: Our data strongly support that PEx originate from RTLF and reflect the composition of undiluted RTLF. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643298 Sat, 28 Jan 2012 05:00:00 +0100 5643298 Junction Site Analysis of Chimeric CYP21A1P/CYP21A2 Genes in 21-Hydroxylase Deficiency [Molecular Diagnostics and Genetics] http://www.medworm.com/index.php?rid=5643297&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F421%3Frss%3D1 CONCLUSIONS: Junction site analysis can explain some genotype–phenotype discrepancies. Sequencing the well-established CYP779f/Tena32F amplicons is an unequivocal strategy for detecting attenuated chimeric CYP21A1P/CYP21A2 genes, which are clinically relevant. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643297 Sat, 28 Jan 2012 05:00:00 +0100 5643297 Circulating Soluble Intercellular Adhesion Molecule 1 and Subclinical Atherosclerosis: the Coronary Artery Risk Development in Young Adults Study [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5643296&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F411%3Frss%3D1 CONCLUSIONS: sICAM-1 concentration may be an early biomarker that indicates changes in the artery wall that accompany atherosclerosis, as well as the presence of advanced plaque in the coronary and carotid arteries. This finding holds in people with low total burden of atherosclerosis, decades before the development of clinical CVD. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643296 Sat, 28 Jan 2012 05:00:00 +0100 5643296 Kinetic Modeling of Storage Effects on Biomarkers Related to B Vitamin Status and One-Carbon Metabolism [General Clinical Chemistry] http://www.medworm.com/index.php?rid=5643295&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F402%3Frss%3D1 CONCLUSIONS: Data on stability and deterioration kinetics for individual biomarkers are required to optimize procedures for handling serum and plasma, and for addressing preanalytical bias in epidemiological and clinical studies. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643295 Sat, 28 Jan 2012 05:00:00 +0100 5643295 Specificity Characteristics of 7 Commercial Creatinine Measurement Procedures by Enzymatic and Jaffe Method Principles [General Clinical Chemistry] http://www.medworm.com/index.php?rid=5643294&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F391%3Frss%3D1 CONCLUSIONS: There were differences in both magnitude and direction of bias among measurement procedures, whether enzymatic or Jaffe. The influence of interfering substances was less frequent with the enzymatic procedures, but no procedure was unaffected. The details of implementation of a method principle influenced its susceptibility to potential interfering substances. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643294 Sat, 28 Jan 2012 05:00:00 +0100 5643294 Aptameric Molecular Switch for Cascade Signal Amplification [Automation and Analytical Techniques] http://www.medworm.com/index.php?rid=5643293&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F384%3Frss%3D1 CONCLUSIONS: The aptameric sensor provides promising potential for detecting and screening trace concentrations of biomarkers in complex matrices for clinical applications. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643293 Sat, 28 Jan 2012 05:00:00 +0100 5643293 Quantification of Methylated Markers with a Multiplex Methylation-Specific Technology [Cancer Diagnostics] http://www.medworm.com/index.php?rid=5643292&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F375%3Frss%3D1 CONCLUSIONS: The QuARTS technology provides a promising approach for quantifying methylated markers. The markers assayed highly discriminated colorectal neoplasia from healthy epithelia. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643292 Sat, 28 Jan 2012 05:00:00 +0100 5643292 Multiplex Immunoassays of Peptide Hormones Extracted from Formalin-Fixed, Paraffin-Embedded Tissue Accurately Subclassify Pituitary Adenomas [Cancer Diagnostics] http://www.medworm.com/index.php?rid=5643291&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F366%3Frss%3D1 CONCLUSIONS: Multiplex immunoassays performed on FFPE tissue extracts can provide diagnostically relevant information and may exceed the performance of IHC in classifying some pituitary neoplasms. This technique is simple, largely amenable to automation, and likely applicable to other diagnostic problems in molecular pathology. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643291 Sat, 28 Jan 2012 05:00:00 +0100 5643291 Searching for New Biomarkers of Renal Diseases through Proteomics [Reviews] http://www.medworm.com/index.php?rid=5643290&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F353%3Frss%3D1 BACKGROUND: Technological advances have resulted in a renaissance of proteomic studies directed at finding markers of disease progression, diagnosis, or responsiveness to therapy. Renal diseases are ideally suited for such research, given that urine is an easily accessible biofluid and its protein content is derived mainly from the kidney. Current renal prognostic markers have limited value, and renal biopsy remains the sole method for establishing a diagnosis. Mass spectrometry instruments, which can detect thousands of proteins at nanomolar (or even femtomolar) concentrations, may be expected to allow the discovery of improved markers of progression, diagnosis, or treatment responsiveness. CONTENT: In this review we describe the strengths and limitations of proteomic methods and the dra... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643290 Sat, 28 Jan 2012 05:00:00 +0100 5643290 Fetal Laboratory Medicine: On the Frontier of Maternal-Fetal Medicine [Reviews] http://www.medworm.com/index.php?rid=5643289&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F337%3Frss%3D1 BACKGROUND: Emerging antenatal interventions and care delivery to the fetus require diagnostic support, including laboratory technologies, appropriate methodologies, establishment of special algorithms, and interpretative guidelines for clinical decision-making. CONTENT: Fetal diagnostic and therapeutic interventions vary in invasiveness and are associated with a spectrum of risks and benefits. Fetal laboratory assessments are well served by miniaturized diagnostic methods for blood analysis. Expedited turnaround times are mandatory to support invasive interventions such as cordocentesis and intrauterine transfusions. Health-associated reference intervals are required for fetal test interpretation. Fetal blood sampling by cordocentesis carries substantial risk and is therefore performed o... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643289 Sat, 28 Jan 2012 05:00:00 +0100 5643289 Commentary [Commentaries] http://www.medworm.com/index.php?rid=5643288&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F335-a%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643288 Sat, 28 Jan 2012 05:00:00 +0100 5643288 A 14-Year-Old Boy with Chronic Cyanosis, Mild Anemia, and Limited Physical Resistance to Stress [Clinical Case Study] http://www.medworm.com/index.php?rid=5643286&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F332%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643286 Sat, 28 Jan 2012 05:00:00 +0100 5643286 Newborn Screening for Metabolic Disorders: How Are We Doing, and Where Are We Going? [Q&A] http://www.medworm.com/index.php?rid=5643285&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F324%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643285 Sat, 28 Jan 2012 05:00:00 +0100 5643285 Breaking the Bottleneck in the Protein Biomarker Pipeline [Perspective] http://www.medworm.com/index.php?rid=5643284&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F321%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643284 Sat, 28 Jan 2012 05:00:00 +0100 5643284 A Strong Start: Plasma Glial Fibrillary Acidic Protein and Stroke Differential Diagnosis [Editorial] http://www.medworm.com/index.php?rid=5643283&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F2%2F319%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5643283 Sat, 28 Jan 2012 05:00:00 +0100 5643283 William Harvey and the Undercurrents of Science [Science in the Arts] http://www.medworm.com/index.php?rid=5549324&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F317%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549324 Wed, 28 Dec 2011 05:00:00 +0100 5549324 A Heart-to-Heart Talk [Unveiling the Right Side] http://www.medworm.com/index.php?rid=5549323&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F315%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549323 Wed, 28 Dec 2011 05:00:00 +0100 5549323 In Reply [Letters to the Editor] http://www.medworm.com/index.php?rid=5549322&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F313%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549322 Wed, 28 Dec 2011 05:00:00 +0100 5549322 High-Sensitivity Cardiac Troponin Assays--Change Is Important [Letters to the Editor] http://www.medworm.com/index.php?rid=5549321&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F311%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549321 Wed, 28 Dec 2011 05:00:00 +0100 5549321 In Reply [Letters to the Editor] http://www.medworm.com/index.php?rid=5549320&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F309%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549320 Wed, 28 Dec 2011 05:00:00 +0100 5549320 Copeptin--A Novel Marker in Acute Myocardial Infarction [Letters to the Editor] http://www.medworm.com/index.php?rid=5549319&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F307%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549319 Wed, 28 Dec 2011 05:00:00 +0100 5549319 Copeptin Adds to High-Sensitivity Troponin T in Rapid Rule Out of Acute Myocardial Infarction [Letters to the Editor] http://www.medworm.com/index.php?rid=5549318&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F306%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549318 Wed, 28 Dec 2011 05:00:00 +0100 5549318 Evidence-Based Laboratory Medicine: How Well Do Laboratories Follow Recommendations and Guidelines? The Cardiac Marker Guideline Uptake in Europe (CARMAGUE) Study [Letters to the Editor] http://www.medworm.com/index.php?rid=5549317&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F305%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549317 Wed, 28 Dec 2011 05:00:00 +0100 5549317 Aspirin in the Primary Prevention of Myocardial Infarction [Citation Classic] http://www.medworm.com/index.php?rid=5549316&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F303%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549316 Wed, 28 Dec 2011 05:00:00 +0100 5549316 Biomarkers for Predicting Serious Cardiac Outcomes at 72 Hours in Patients Presenting Early after Chest Pain Onset with Symptoms of Acute Coronary Syndromes [Brief Communications] http://www.medworm.com/index.php?rid=5549315&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F298%3Frss%3D1 CONCLUSIONS: The optimal cutoffs for predicting serious cardiac outcomes in this low-risk population are different from the published 99th percentiles. Larger studies are required to verify these findings. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549315 Wed, 28 Dec 2011 05:00:00 +0100 5549315 Comparison of Midregional Pro-A-Type Natriuretic Peptide and the N-Terminal Pro-B-Type Natriuretic Peptide for Predicting Mortality and Cardiovascular Events [Brief Communications] http://www.medworm.com/index.php?rid=5549314&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F293%3Frss%3D1 CONCLUSIONS: MR-proANP was as efficient as NT-proBNP in predicting all-cause mortality, cardiovascular mortality, and cardiovascular events; however, its association with cardiovascular mortality was not independent from other confounders. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549314 Wed, 28 Dec 2011 05:00:00 +0100 5549314 Troponin T Measurements by High-Sensitivity vs Conventional Assays for Risk Stratification in Acute Dyspnea [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549313&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F284%3Frss%3D1 CONCLUSIONS: hs-cTnT is associated with mortality in patients presenting with acute dyspnea. hs-cTnT concentrations provide additional prognostic information to cTnT and NT-proBNP testing in patients with cTnT concentrations below the detection limit. In particular, the hs-cTnT cutoff of 0.016 μg/L enables identification of low-risk patients. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549313 Wed, 28 Dec 2011 05:00:00 +0100 5549313 Concordance, Variance, and Outliers in 4 Contemporary Cardiac Troponin Assays: Implications for Harmonization [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549312&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F274%3Frss%3D1 CONCLUSIONS: The universal definition of myocardial infarction should not depend on the choice of analyte or analyzer, and the between- and within-method differences described here need to be considered in the application of cardiac troponin in this respect. The variation between methods that cannot be explained by analytical imprecision and the discordant classification of results according to the respective 99th percentiles should be addressed. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549312 Wed, 28 Dec 2011 05:00:00 +0100 5549312 Galectin-3 and the Development of Heart Failure after Acute Coronary Syndrome: Pilot Experience from PROVE IT-TIMI 22 [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549311&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F267%3Frss%3D1 CONCLUSIONS: The finding that galectin-3 is associated with the risk of developing HF following ACS adds to emerging evidence supporting galectin-3 as a biomarker of adverse remodeling contributing to HF as well as a potential therapeutic target. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549311 Wed, 28 Dec 2011 05:00:00 +0100 5549311 Role of ST2 in Non-ST-Elevation Acute Coronary Syndrome in the MERLIN-TIMI 36 Trial [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549310&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F257%3Frss%3D1 CONCLUSIONS: ST2 correlates weakly with biomarkers of acute injury and hemodynamic stress but is strongly associated with the risk of HF after NSTE-ACS. This biomarker and related pathway merit further investigation as potential therapeutic targets for patients with ACS at risk for cardiac remodeling. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549310 Wed, 28 Dec 2011 05:00:00 +0100 5549310 Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549309&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F246%3Frss%3D1 CONCLUSIONS: Biomarkers of plaque instability do not seem helpful in the early diagnosis of AMI but may provide some incremental value in the risk stratification of patients with acute chest pain. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549309 Wed, 28 Dec 2011 05:00:00 +0100 5549309 Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549308&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F237%3Frss%3D1 CONCLUSIONS: Plasma GFAP analysis performed within 4.5 h of symptom onset can differentiate ICH and ischemic stroke. Studies are needed to evaluate a GFAP point-of-care system that may help optimize the prehospital triage and management of patients with symptoms of acute stroke. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549308 Wed, 28 Dec 2011 05:00:00 +0100 5549308 Midregional Proadrenomedullin for Prediction of Cardiovascular Events in Coronary Artery Disease: Results from the AtheroGene Study [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549307&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F226%3Frss%3D1 CONCLUSIONS: MR-proADM is an independent predictor for future cardiovascular events in patients with symptomatic coronary artery disease, providing information comparable to NT-proBNP for secondary risk stratification. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549307 Wed, 28 Dec 2011 05:00:00 +0100 5549307 Influence of Population Selection on the 99th Percentile Reference Value for Cardiac Troponin Assays [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549306&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F219%3Frss%3D1 CONCLUSIONS: The reference population selection strategy significantly influenced the 99th percentile reference values determined for troponin assays and the observed sex differences in troponin concentrations. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549306 Wed, 28 Dec 2011 05:00:00 +0100 5549306 Absolute and Relative Kinetic Changes of High-Sensitivity Cardiac Troponin T in Acute Coronary Syndrome and in Patients with Increased Troponin in the Absence of Acute Coronary Syndrome [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5549305&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F209%3Frss%3D1 CONCLUSIONS: Absolute changes appear superior to relative changes in discriminating non-STEMI. A rise or fall of at least 9.2 ng/L in the entire study population and 6.9 ng/L in selected ACS patients seems adequate to rule-out non-STEMI. However, -values are useful to rule-in non-STEMI only in a specific ACS population. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549305 Wed, 28 Dec 2011 05:00:00 +0100 5549305 Circulating Troponin As Measured by a Sensitive Assay for Cardiovascular Risk Assessment in Primary Prevention [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5549304&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F200%3Frss%3D1 CONCLUSIONS: Minute increases in cTnI are associated with increased mortality and incident MACE in a large primary prevention cohort and, thus, identify contributors to cardiovascular risk not fully captured by traditional risk factor assessment. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549304 Wed, 28 Dec 2011 05:00:00 +0100 5549304 Cystatin C and Estimated Glomerular Filtration Rate as Predictors for Adverse Outcome in Patients with ST-Elevation and Non-ST-Elevation Acute Coronary Syndromes: Results from the Platelet Inhibition and Patient Outcomes Study [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5549303&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F190%3Frss%3D1 CONCLUSIONS: Cystatin C concentration contributes independently in predicting the risk of cardiovascular death or myocardial infarction in NSTE-ACS, with no interaction by type of ACS. CKD-EPI exhibited the largest predictive value of all renal markers. Nevertheless, the additive predictive value of cystatin C or creatinine-based eGFR measures in the unselected ACS patient is small. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549303 Wed, 28 Dec 2011 05:00:00 +0100 5549303 Rosuvastatin, Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations, and LDL Cholesterol Response: the JUPITER Trial [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5549302&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F183%3Frss%3D1 CONCLUSIONS: In this randomized trial, rosuvastatin increased plasma concentration of PCSK9 in proportion to the magnitude of LDL-C reduction; the LDL-C response to statin could not be inferred by PCSK9 concentrations. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549302 Wed, 28 Dec 2011 05:00:00 +0100 5549302 Association of Growth Differentiation Factor-15 with Coronary Atherosclerosis and Mortality in a Young, Multiethnic Population: Observations from the Dallas Heart Study [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5549301&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F172%3Frss%3D1 CONCLUSIONS: GDF-15 is independently associated with subclinical coronary atherosclerosis and mortality, and its potential role for risk stratification in the general population merits further evaluation. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549301 Wed, 28 Dec 2011 05:00:00 +0100 5549301 Counterpoint: Standardization of Cardiac Troponin I Assays Will Not Occur in My Lifetime [Point/Counterpoint] http://www.medworm.com/index.php?rid=5549300&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F169%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549300 Wed, 28 Dec 2011 05:00:00 +0100 5549300 Point: Put Simply, Standardization of Cardiac Troponin I Is Complicated [Point/Counterpoint] http://www.medworm.com/index.php?rid=5549299&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F165%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549299 Wed, 28 Dec 2011 05:00:00 +0100 5549299 Counterpoint: Detection of Myocardial Infarction--Is It All Troponin? Role of New Markers [Point/Counterpoint] http://www.medworm.com/index.php?rid=5549298&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F162%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549298 Wed, 28 Dec 2011 05:00:00 +0100 5549298 Point: Detection of Myocardial Infarction--Is It All Troponin? [Point/Counterpoint] http://www.medworm.com/index.php?rid=5549297&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F158%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549297 Wed, 28 Dec 2011 05:00:00 +0100 5549297 Clopidogrel and CYP2C19 Testing: Ready for Clinical Prime Time? [Opinions] http://www.medworm.com/index.php?rid=5549296&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F154%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549296 Wed, 28 Dec 2011 05:00:00 +0100 5549296 Are There Really Biomarkers of Vulnerable Plaque? [Opinions] http://www.medworm.com/index.php?rid=5549295&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F151%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549295 Wed, 28 Dec 2011 05:00:00 +0100 5549295 Troponin Release--Reversible or Irreversible Injury? Should We Care? [Opinions] http://www.medworm.com/index.php?rid=5549294&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F148%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549294 Wed, 28 Dec 2011 05:00:00 +0100 5549294 Metabolomics and Cardiovascular Biomarker Discovery [Reviews] http://www.medworm.com/index.php?rid=5549293&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F139%3Frss%3D1 BACKGROUND: Metabolomics, the systematic analysis of low molecular weight biochemical compounds in a biological specimen, has been increasingly applied to biomarker discovery. CONTENT: Because no single analytical method can accommodate the chemical diversity of the entire metabolome, various methods such as nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) have been employed, with the latter coupled to an array of separation techniques including gas and liquid chromatography. Whereas NMR can provide structural information and absolute quantification for select metabolites without the use of exogenous standards, MS tends to have much higher analytical sensitivity, enabling broader surveys of the metabolome. Both NMR and MS can be used to characterize metabolite data... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549293 Wed, 28 Dec 2011 05:00:00 +0100 5549293 Emerging Biomarkers in Heart Failure [Reviews] http://www.medworm.com/index.php?rid=5549292&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F127%3Frss%3D1 BACKGROUND: Until recently, biomarker testing in heart failure (HF) syndromes has been viewed as an elective supplement to diagnostic evaluation of patients suspected to suffer from this condition. This approach to the use of biomarker testing contrasts with other cardiovascular diagnoses such as acute myocardial infarction, for which biomarkers are integral to disease process definition, risk stratification, and in some cases treatment decision making. CONTENT: In this review we consider various perspectives on the evaluation of biomarkers in HF. In addition, we examine recent advances in the understanding of established biomarkers in HF (such as the natriuretic peptides), the elucidation of novel biomarkers potentially useful for the evaluation and management of patients with HF, and th... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549292 Wed, 28 Dec 2011 05:00:00 +0100 5549292 Next Steps in Cardiovascular Disease Genomic Research--Sequencing, Epigenetics, and Transcriptomics [Reviews] http://www.medworm.com/index.php?rid=5549291&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F113%3Frss%3D1 BACKGROUND: Genomic research in cardiovascular disease (CVD) has progressed rapidly over the last 5 years. In most cases, however, these groundbreaking observations have not yet been accompanied by clinically applicable tools for risk prediction, diagnosis, or therapeutic interventions. CONTENT: We reviewed the scientific literature published in English for novel methods and promising genomic targets that would permit large-scale screening and follow-up of recent genomic findings for CVD. We anticipate that advances in 3 key areas will be critical for the success of these projects. First, exome-centered and whole-genome next-generation sequencing will identify rare and novel genetic variants associated with CVD and its risk factors. Improvements in methods will also greatly advance the fi... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549291 Wed, 28 Dec 2011 05:00:00 +0100 5549291 9p21 and the Genetic Revolution for Coronary Artery Disease [Reviews] http://www.medworm.com/index.php?rid=5549290&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F104%3Frss%3D1 BACKGROUND: It has long been recognized that 50% of the susceptibility for coronary artery disease (CAD) is due to predisposing genetic factors. Comprehensive prevention is likely to require knowledge of these genetic factors. CONTENT: Using a genomewide association study (GWAS), the Ottawa Heart Genomic Study and the deCODE group simultaneously identified the first genetic risk variant, at chromosome 9p21. The 9p21 variant became the first risk factor to be identified since 1964. 9p21 occurs in 75% of the population except for African Americans and is associated with a 25% increased risk for CAD with 1 copy and a 50% increased risk with 2 copies. Perhaps the most remarkable finding is that 9p21 is independent of all known risk factors, indicating there are factors contributing to the pat... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549290 Wed, 28 Dec 2011 05:00:00 +0100 5549290 Genomewide Association Studies in Cardiovascular Disease--An Update 2011 [Reviews] http://www.medworm.com/index.php?rid=5549289&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F92%3Frss%3D1 BACKGROUND: Genomewide association studies have led to an enormous boost in the identification of susceptibility genes for cardiovascular diseases. This review aims to summarize the most important findings of recent years. CONTENT: We have carefully reviewed the current literature (PubMed search terms: "genome wide association studies," "genetic polymorphism," "genetic risk factors," "association study" in connection with the respective diseases, "risk score," "transcriptome"). SUMMARY: Multiple novel genetic loci for such important cardiovascular diseases as myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia have been identified. Given that many novel genetic risk factors lie within hitherto-unsuspected genes or influence gene expression, these findings have ... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549289 Wed, 28 Dec 2011 05:00:00 +0100 5549289 B-Type Natriuretic Peptide: From Posttranslational Processing to Clinical Measurement [Reviews] http://www.medworm.com/index.php?rid=5549288&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F83%3Frss%3D1 BACKGROUND: Plasma cardiac natriuretic peptides and peptide fragments from their molecular precursors are markers of heart disease. Clinical studies have defined the current diagnostic utility of these markers, whereas biochemical elucidation of peptide structure and posttranslational processing has revealed new plasma peptide forms of potential clinical use. CONTENT: Natriuretic propeptide structures undergo variable degrees of endo- and exoproteolytic cleavages as well as amino acid modifications, which leave the plasma phase of the peptides highly heterogeneous and dependent on cardiac pathophysiology and capacity. An ongoing characterization of the molecular heterogeneity may not only help us to appreciate the biosynthetic capacity of the endocrine heart but may also lead to the disco... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549288 Wed, 28 Dec 2011 05:00:00 +0100 5549288 Biomarkers and Cardiovascular Risk Assessment for Primary Prevention: An Update [Reviews] http://www.medworm.com/index.php?rid=5549287&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F72%3Frss%3D1 BACKGROUND: Interest in cardiovascular biomarkers in primary prevention has increased dramatically in the past decade. This increase has been fueled by an improved understanding of cardiovascular pathophysiology, as well as novel technologies for biomarker identification. CONTENT: In this review we provide a brief overview of recent concepts in the evaluation of screening biomarkers, because biomarkers may behave differently when used for screening as opposed to diagnosis or disease staging. The following specific biomarker examples are then discussed, with a focus on data from primary prevention studies: high-sensitivity C-reactive protein, B-type natriuretic peptide, lipoprotein-associated phospholipase A2, and high-sensitivity troponin T. The article concludes by addressing novel platf... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549287 Wed, 28 Dec 2011 05:00:00 +0100 5549287 Use of Natriuretic Peptides to Guide and Monitor Heart Failure Therapy [Reviews] http://www.medworm.com/index.php?rid=5549286&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F62%3Frss%3D1 BACKGROUND: Plasma B-type cardiac natriuretic peptides reflect cardiac structure and function and have proven roles in assisting in the diagnosis of acute heart failure. They are independent prognostic indicators across the full spectrum of cardiovascular disease. Serial changes in plasma B-type cardiac natriuretic peptides parallel prognosis in chronic heart failure. Beneficial responses to medications and devices used in the treatment of heart failure are associated with decreases in plasma B-type peptide concentrations. This effect has led to the hypothesis that intensified treatment directed at reducing B-peptide concentrations may improve outcomes in heart failure. CONTENT: The efficacy of serial measurements of plasma B-type peptides in guiding titration of therapy for chronic heart... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549286 Wed, 28 Dec 2011 05:00:00 +0100 5549286 Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays [Mini-Reviews] http://www.medworm.com/index.php?rid=5549285&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F54%3Frss%3D1 BACKGROUND: Cardiac troponins I (cTnI) and T (cTnT) have received international endorsement as the standard biomarkers for detection of myocardial injury, for risk stratification in patients suspected of acute coronary syndrome, and for the diagnosis of myocardial infarction. An evidence-based clinical database is growing rapidly for high-sensitivity (hs) troponin assays. Thus, clarifications of the analytical principles for the immunoassays used in clinical practice are important. CONTENT: The purpose of this mini-review is (a) to provide a background for the biochemistry of cTnT and cTnI and (b) to address the following analytical questions for both hs cTnI and cTnT assays: (i) How does an assay become designated hs? (ii) How does one realistically define healthy (normal) reference popu... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549285 Wed, 28 Dec 2011 05:00:00 +0100 5549285 Biomarkers in Cardiovascular Clinical Trials: Past, Present, Future [Mini-Reviews] http://www.medworm.com/index.php?rid=5549284&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F45%3Frss%3D1 BACKGROUND: Cardiovascular (CV) clinical trials are instrumental in understanding treatment effects and offer insights into the natural progression of CV disease. Biomarkers are a critical component of patient selection, end point definition, and safety monitoring, and clinical trials provide a platform for the discovery and validation of new biomarkers that may augment the understanding of disease mechanisms, risk stratification, and/or clinical decision-making. CONTENT: We review the roles that biomarkers have played in CV clinical trials and roles that CV clinical trials have played and will continue to play in the discovery and validation of biomarkers and their implementation in clinical practice. Large biobanks containing multiple specimen types are increasingly being created from p... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549284 Wed, 28 Dec 2011 05:00:00 +0100 5549284 Commentary [Commentaries] http://www.medworm.com/index.php?rid=5549283&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F44%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549283 Wed, 28 Dec 2011 05:00:00 +0100 5549283 Interpreting Changes in Troponin--Clinical Judgment Is Essential [Clinical Case Study] http://www.medworm.com/index.php?rid=5549281&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F39%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549281 Wed, 28 Dec 2011 05:00:00 +0100 5549281 The Challenges and Concerns Companies Face Pertaining to the US Food and Drug Administration 510(k) Process for Cardiac Biomarkers [Q&A] http://www.medworm.com/index.php?rid=5549280&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F31%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549280 Wed, 28 Dec 2011 05:00:00 +0100 5549280 Within Sight of a Rational Pipeline for Development of Protein Diagnostics [Perspectives] http://www.medworm.com/index.php?rid=5549279&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F28%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549279 Wed, 28 Dec 2011 05:00:00 +0100 5549279 A Novel Technology for Measuring Cumulative Cardiac Biomarker Exposure over Time: What Happened When We Weren't Looking? [Perspectives] http://www.medworm.com/index.php?rid=5549278&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F25%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549278 Wed, 28 Dec 2011 05:00:00 +0100 5549278 Reflections on the Evolution of Cardiac Biomarkers [Reflection] http://www.medworm.com/index.php?rid=5549277&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F21%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549277 Wed, 28 Dec 2011 05:00:00 +0100 5549277 An Interview with Dr. Eugene Braunwald [Interview] http://www.medworm.com/index.php?rid=5549276&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F11%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549276 Wed, 28 Dec 2011 05:00:00 +0100 5549276 Delta Cardiac Troponin Values in Practice: Are We Ready to Move Absolutely Forward to Clinical Routine? [Editorials] http://www.medworm.com/index.php?rid=5549275&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F8%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549275 Wed, 28 Dec 2011 05:00:00 +0100 5549275 Statins, Plasma Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations, and LDL Lowering [Editorials] http://www.medworm.com/index.php?rid=5549274&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F6%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549274 Wed, 28 Dec 2011 05:00:00 +0100 5549274 Growth Differentiation Factor 15: A Canary in a Coal Mine? [Editorials] http://www.medworm.com/index.php?rid=5549273&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F3%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549273 Wed, 28 Dec 2011 05:00:00 +0100 5549273 Impact of Biomarkers, Proteomics, and Genomics in Cardiovascular Disease [Introduction] http://www.medworm.com/index.php?rid=5549272&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F58%2F1%2F1%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5549272 Wed, 28 Dec 2011 05:00:00 +0100 5549272 On Chemistry, Scientists, and the Arts [International Year of Chemistry 2011] http://www.medworm.com/index.php?rid=5453655&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1790%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453655 Mon, 28 Nov 2011 05:00:00 +0100 5453655 Playing the Trumpet [Unveiling the Right Side] http://www.medworm.com/index.php?rid=5453654&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1789%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453654 Mon, 28 Nov 2011 05:00:00 +0100 5453654 The Personal Genome Machine--DNA Decoding with Semiconductors [Technology Corner] http://www.medworm.com/index.php?rid=5453653&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1786%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453653 Mon, 28 Nov 2011 05:00:00 +0100 5453653 "Reaching Out to the World" Appreciation [News & Views] http://www.medworm.com/index.php?rid=5453652&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1784%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453652 Mon, 28 Nov 2011 05:00:00 +0100 5453652 Clinical Chemistry's Invited Reviewers 2011 [News & Views] http://www.medworm.com/index.php?rid=5453651&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1782%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453651 Mon, 28 Nov 2011 05:00:00 +0100 5453651 Clinical Chemistry Trainee Council Advisory Board [News & Views] http://www.medworm.com/index.php?rid=5453650&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1781%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453650 Mon, 28 Nov 2011 05:00:00 +0100 5453650 Call for Nominations [News & Views] http://www.medworm.com/index.php?rid=5453649&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1780%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453649 Mon, 28 Nov 2011 05:00:00 +0100 5453649 An 83-Year-Old Woman with Discordant Urine Protein Results [What Is Your Guess?] http://www.medworm.com/index.php?rid=5453648&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1779%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453648 Mon, 28 Nov 2011 05:00:00 +0100 5453648 Correction [Correction] http://www.medworm.com/index.php?rid=5453647&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1778%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453647 Mon, 28 Nov 2011 05:00:00 +0100 5453647 Is the WHO 90:10 Prostate-Specific Antigen (PSA) First International Reference Standard Really 90% {alpha}1-Antichymotrypsin-Bound PSA and 10% Free PSA? [Letter to the Editor] http://www.medworm.com/index.php?rid=5453646&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1776%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453646 Mon, 28 Nov 2011 05:00:00 +0100 5453646 John Savory [Inspiring Minds] http://www.medworm.com/index.php?rid=5453645&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1773%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453645 Mon, 28 Nov 2011 05:00:00 +0100 5453645 Advances in the Clinical Staging of Chronic Lymphocytic Leukemia [Citation Classic] http://www.medworm.com/index.php?rid=5453644&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1771%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453644 Mon, 28 Nov 2011 05:00:00 +0100 5453644 Risk Prediction with Serial Myeloperoxidase Monitoring in Patients with Acute Chest Pain [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5453643&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1762%3Frss%3D1 CONCLUSIONS: MPO concentrations are predictive of outcome up to 16 h after presentation with chest pain and predict events missed by cTnI testing, supporting a potential role in rapid patient triage. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453643 Mon, 28 Nov 2011 05:00:00 +0100 5453643 C-Reactive Protein Induces Release of Both Endothelial Microparticles and Circulating Endothelial Cells In Vitro and In Vivo: Further Evidence of Endothelial Dysfunction [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5453642&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1757%3Frss%3D1 CONCLUSIONS: We provide novel data that CRP, via NO deficiency, promotes endothelial dysfunction by inducing release of CECs and EMPs, which are biomarkers of endothelial dysfunction. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453642 Mon, 28 Nov 2011 05:00:00 +0100 5453642 Urinary Excretion Kinetics of 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) and Its Phase I and Phase II Metabolites in Humans following Controlled MDMA Administration [Drug Monitoring and Toxicology] http://www.medworm.com/index.php?rid=5453641&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1748%3Frss%3D1 CONCLUSIONS: Human MDMA urinary metabolites are primarily sulfates and glucuronides,with sulfates present in higher concentrations than glucuronides. Thisnew knowledge may lead to improvements in urine MDMA and metaboliteanalysis in clinical and forensic toxicology, particularly for theperformance of direct urine analysis. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453641 Mon, 28 Nov 2011 05:00:00 +0100 5453641 The Need for Standardization of Tacrolimus Assays [Drug Monitoring and Toxicology] http://www.medworm.com/index.php?rid=5453640&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1739%3Frss%3D1 CONCLUSIONS: Tacrolimus assay standardization will be necessary to compare patient results between clinical laboratories. Improved assay accuracy is required to provide optimized drug dosing and consistent care across transplant centers globally. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453640 Mon, 28 Nov 2011 05:00:00 +0100 5453640 Simultaneous Detection of High-Sensitivity Cardiac Troponin I and Myoglobin by Modified Sandwich Lateral Flow Immunoassay: Proof of Principle [Point-of-Care Testing] http://www.medworm.com/index.php?rid=5453639&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1732%3Frss%3D1 CONCLUSIONS: The described proof-of-principle LFIA method could be used as a point-of-care device in multiple protein quantification and semiquantitative analysis. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453639 Mon, 28 Nov 2011 05:00:00 +0100 5453639 Altered Profile of Seminal Plasma MicroRNAs in the Molecular Diagnosis of Male Infertility [Molecular Diagnostics and Genetics] http://www.medworm.com/index.php?rid=5453638&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1722%3Frss%3D1 CONCLUSIONS: The measurement of miRNAs in seminal plasma provides a novel, noninvasive approach for diagnosing male infertility. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453638 Mon, 28 Nov 2011 05:00:00 +0100 5453638 Fifth-Generation Digital Immunoassay for Prostate-Specific Antigen by Single Molecule Array Technology [Cancer Diagnostics] http://www.medworm.com/index.php?rid=5453637&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1712%3Frss%3D1 CONCLUSIONS: The robust 2-log improvement in limit of quantification relative to current ultrasensitive assays and the validated analytical performance of the assay allow for accurate assessment of PSA status after RP. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453637 Mon, 28 Nov 2011 05:00:00 +0100 5453637 The Impact of Delayed Storage on the Measured Proteome and Metabolome of Human Cerebrospinal Fluid [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5453636&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1703%3Frss%3D1 CONCLUSIONS: The measured proteome and metabolome of centrifuged human CSF is stable at room temperature for up to 2 hours. We cannot exclude, however, that changes undetectable with our current methodology, such as denaturation or proteolysis, might occur because of sample handling conditions. The stability we observed gives laboratory personnel at the collection site sufficient time to aliquot samples before freezing and storage at –80 °C. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453636 Mon, 28 Nov 2011 05:00:00 +0100 5453636 Diabetes Antibody Standardization Program: First Proficiency Evaluation of Assays for Autoantibodies to Zinc Transporter 8 [Clinical Immunology] http://www.medworm.com/index.php?rid=5453635&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1693%3Frss%3D1 CONCLUSIONS: The DASP workshop identified immunoprecipitation-based ZnT8A assays and antigen constructs that achieved both a high degree of sensitivity and specificity and were suitable for more widespread clinical application. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453635 Mon, 28 Nov 2011 05:00:00 +0100 5453635 Long-Term Biological Variation of Serum Protein Electrophoresis M-Spike, Urine M-Spike, and Monoclonal Serum Free Light Chain Quantification: Implications for Monitoring Monoclonal Gammopathies [Clinical Immunology] http://www.medworm.com/index.php?rid=5453634&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1687%3Frss%3D1 CONCLUSIONS: The variations in urine M-spike and serum FLC measurements during patient monitoring are similar and are larger than those for serum M-spikes. In addition, in this group of stable patients, a measurable serum FLC concentration was available twice as often as a measurable urine M-spike. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453634 Mon, 28 Nov 2011 05:00:00 +0100 5453634 Prospective Registration of Marker Evaluation Studies: Time to Act [Opinions] http://www.medworm.com/index.php?rid=5453633&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1684%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453633 Mon, 28 Nov 2011 05:00:00 +0100 5453633 "Research Use Only" Reagents: Is There an Imperative for Increased FDA Oversight? [Opinions] http://www.medworm.com/index.php?rid=5453632&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1681%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453632 Mon, 28 Nov 2011 05:00:00 +0100 5453632 Proficiency Testing/External Quality Assessment: Current Challenges and Future Directions [Reviews] http://www.medworm.com/index.php?rid=5453631&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1670%3Frss%3D1 BACKGROUND: Proficiency testing (PT), or external quality assessment (EQA), is intended to verify on a recurring basis that laboratory results conform to expectations for the quality required for patient care. CONTENT: Key factors for interpreting PT/EQA results are knowledge of the commutability of the samples used and the process used for target value assignment. A commutable PT/EQA sample demonstrates the same numeric relationship between different measurement procedures as that expected for patients' samples. Noncommutable PT/EQA samples frequently have a matrix-related bias of unknown magnitude that limits interpretation of results. PT/EQA results for commutable samples can be used to assess accuracy against a reference measurement procedure or a designated comparison method. In addi... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453631 Mon, 28 Nov 2011 05:00:00 +0100 5453631 Hepcidin in Human Iron Disorders: Diagnostic Implications [Reviews] http://www.medworm.com/index.php?rid=5453630&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1650%3Frss%3D1 We describe hepcidin structure, kinetics, function, and regulation. We moreover explore the therapeutic potential for modulating hepcidin expression and the diagnostic potential for hepcidin measurements in clinical practice. SUMMARY: Cell-culture, animal, and human studies have shown that hepcidin is predominantly synthesized by hepatocytes, where its expression is regulated by body iron status, erythropoietic activity, oxygen tension, and inflammatory cytokines. Hepcidin lowers serum iron concentrations by counteracting the function of ferroportin, a major cellular iron exporter present in the membrane of macrophages, hepatocytes, and the basolateral site of enterocytes. Hepcidin is detected in biologic fluids as a 25 amino acid isoform, hepcidin-25, and 2 smaller forms, i.e., hepcidin-... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453630 Mon, 28 Nov 2011 05:00:00 +0100 5453630 Commentary [Commentaries] http://www.medworm.com/index.php?rid=5453629&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1649%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453629 Mon, 28 Nov 2011 05:00:00 +0100 5453629 A 71-Year-Old Woman with Multiple Myeloma Status after Stem Cell Transplantation [Clinical Case Study] http://www.medworm.com/index.php?rid=5453627&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1645%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453627 Mon, 28 Nov 2011 05:00:00 +0100 5453627 Direct-to-Consumer Genetic Testing: Reliable or Risky? [Q&A] http://www.medworm.com/index.php?rid=5453626&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1641%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453626 Mon, 28 Nov 2011 05:00:00 +0100 5453626 Whole-Genome Sequencing Informs Treatment: Personalized Medicine Takes Another Step Forward [Perspective] http://www.medworm.com/index.php?rid=5453625&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1638%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453625 Mon, 28 Nov 2011 05:00:00 +0100 5453625 Improved Monitoring of Differences in Serial Laboratory Results [Editorial] http://www.medworm.com/index.php?rid=5453624&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F12%2F1635%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5453624 Mon, 28 Nov 2011 05:00:00 +0100 5453624 William Cullen and Joseph Black: Chemistry, Medicine, and the Scottish Enlightenment [International Year of Chemistry 2011] http://www.medworm.com/index.php?rid=5373709&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1632%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373709 Fri, 28 Oct 2011 04:00:00 +0100 5373709 Humphry Davy and the Chemical Moment [International Year of Chemistry 2011] http://www.medworm.com/index.php?rid=5373708&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1625%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373708 Fri, 28 Oct 2011 04:00:00 +0100 5373708 The Beauty and Truth of the Citric Acid Cycle [Unveiling the Right Side] http://www.medworm.com/index.php?rid=5373707&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1623%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373707 Fri, 28 Oct 2011 04:00:00 +0100 5373707 Too Many Roads Not Taken in Biomarker Discovery: The Story of Missing Tools [News & Views] http://www.medworm.com/index.php?rid=5373706&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1621%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373706 Fri, 28 Oct 2011 04:00:00 +0100 5373706 What Is Wrong with This Picture? [What is your Guess?] http://www.medworm.com/index.php?rid=5373705&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1620%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373705 Fri, 28 Oct 2011 04:00:00 +0100 5373705 Fast Separation of 25-Hydroxyvitamin D3 from 3-Epi-25-Hydroxyvitamin D3 in Human Serum by Liquid Chromatography-Tandem Mass Spectrometry: Variable Prevalence of 3-Epi-25-Hydroxyvitamin D3 in Infants, Children, and Adults [Letters to the Editor] http://www.medworm.com/index.php?rid=5373704&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1618%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373704 Fri, 28 Oct 2011 04:00:00 +0100 5373704 Long-Term Stability of Clinical Laboratory Data--Sodium as Benchmark [Letters to the Editor] http://www.medworm.com/index.php?rid=5373703&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1616%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373703 Fri, 28 Oct 2011 04:00:00 +0100 5373703 Profile of MicroRNAs Differentially Produced in Hearts from Patients with Hypertrophic Cardiomyopathy and Sarcomeric Mutations [Letters to the Editor] http://www.medworm.com/index.php?rid=5373702&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1614%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373702 Fri, 28 Oct 2011 04:00:00 +0100 5373702 Turning Catabolism into Usefulness--A Jaundiced View [Citation Classic] http://www.medworm.com/index.php?rid=5373701&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1612%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373701 Fri, 28 Oct 2011 04:00:00 +0100 5373701 Reference Values for Aldosterone-Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium Consumption [Brief Communication] http://www.medworm.com/index.php?rid=5373700&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1607%3Frss%3D1 CONCLUSIONS: We present reference values for the ARRprc for healthy individuals. The ARR is affected to a variable degree by sex and sodium intake. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373700 Fri, 28 Oct 2011 04:00:00 +0100 5373700 Oral Fluid and Plasma Cannabinoid Ratios after Around-the-Clock Controlled Oral {Delta}9-Tetrahydrocannabinol Administration [Drug Monitoring and Toxicology] http://www.medworm.com/index.php?rid=5373699&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1597%3Frss%3D1 CONCLUSIONS: OF monitoring does not reliably detect oral dronabinol intake. The time courses of THC and THCCOOH concentrations in plasma and OF were different after repeated oral THC doses, and high interindividual variation was observed. For these reasons, OF cannabinoid concentrations cannot predict concurrent plasma concentrations. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373699 Fri, 28 Oct 2011 04:00:00 +0100 5373699 Motor Chip: A Comparative Genomic Hybridization Microarray for Copy-Number Mutations in 245 Neuromuscular Disorders [Molecular Diagnostics And Genetics] http://www.medworm.com/index.php?rid=5373698&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1584%3Frss%3D1 CONCLUSIONS: The combination of exon-specific gene coverage and optimized platform and probe selection makes the Motor Chip a complementary tool for molecular diagnosis and gene investigation in neuromuscular diseases. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373698 Fri, 28 Oct 2011 04:00:00 +0100 5373698 A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients [Molecular Diagnostics and Genetics] http://www.medworm.com/index.php?rid=5373697&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1574%3Frss%3D1 CONCLUSIONS: The CYP3A4 rs35599367C>T polymorphism is associated with a significantly altered Tac metabolism and therefore increases the risk of supratherapeutic Tac concentrations early after transplantation. Analysis of this CYP3A4*22 SNP may help in identifying patients at risk of Tac overexposure. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373697 Fri, 28 Oct 2011 04:00:00 +0100 5373697 Investigating Interferences of a Whole-Blood Point-of-Care Creatinine Analyzer: Comparison to Plasma Enzymatic and Definitive Creatinine Methods in an Acute-Care Setting [Point-of-Care Testing] http://www.medworm.com/index.php?rid=5373696&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1566%3Frss%3D1 CONCLUSIONS: These data suggest that whole-blood POC creatinine measurements should be used with caution. Negative interferences observed with these measurements could erroneously suggest adequate renal function near the decision threshold, particularly if estimated glomerular filtration rate is determined. Disparity between whole-blood and plasma matrices partially explains the discordance between whole-blood and plasma creatinine methods. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373696 Fri, 28 Oct 2011 04:00:00 +0100 5373696 Fibulin-1 Is a Marker for Arterial Extracellular Matrix Alterations in Type 2 Diabetes [Endocrinology and Metabolism] http://www.medworm.com/index.php?rid=5373695&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1556%3Frss%3D1 CONCLUSIONS: Fibulin-1 accumulates in the arterial wall and in plasma of patients with type 2 diabetes, and appears to be a factor associated with arterial extracellular matrix changes in type 2 diabetes. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373695 Fri, 28 Oct 2011 04:00:00 +0100 5373695 High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples [General Clinical Chemistry] http://www.medworm.com/index.php?rid=5373694&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1545%3Frss%3D1 CONCLUSIONS: The TMAD methodology described here enables semiautomated, high-throughput sampling of small amounts of heterogeneous tissue specimens by multiple analytical techniques with generally improved quality of recovered biomolecules. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373694 Fri, 28 Oct 2011 04:00:00 +0100 5373694 Comparison of Serum Human Epididymis Protein 4 with Cancer Antigen 125 as a Tumor Marker in Patients with Malignant and Nonmalignant Diseases [Cancer Diagnostics] http://www.medworm.com/index.php?rid=5373693&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1534%3Frss%3D1 CONCLUSIONS: HE4 has significantly higher diagnostic specificity than CA 125, and the combination of CA 125 and HE4 improved the detection of ovarian cancer in all stages and histological types. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373693 Fri, 28 Oct 2011 04:00:00 +0100 5373693 Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP Activation in Hypercholesterolemic Individuals [Lipids, Lipoproteins, and Cardiovascular Risk Factors] http://www.medworm.com/index.php?rid=5373692&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1524%3Frss%3D1 CONCLUSIONS: Anthocyanin supplementation improves endothelium-dependent vasodilation in hypercholesterolemic individuals. This effect involves activation of the NO-cGMP signaling pathway, improvements in the serum lipid profile, and decreased inflammation. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373692 Fri, 28 Oct 2011 04:00:00 +0100 5373692 European Specialist Porphyria Laboratories: Diagnostic Strategies, Analytical Quality, Clinical Interpretation, and Reporting As Assessed by an External Quality Assurance Program [Evidence-Based Medicine and Test Utilization] http://www.medworm.com/index.php?rid=5373691&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1514%3Frss%3D1 CONCLUSIONS: Based on a case-based EQA scheme, variations were apparent in analytical and diagnostic performance between European specialist porphyria laboratories. Our findings reinforce the use of EQA schemes as an essential tool to assess both analytical and diagnostic processes and thereby to improve patient care in rare diseases. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373691 Fri, 28 Oct 2011 04:00:00 +0100 5373691 Specific Immunoassay Reveals Increased Serum Trypsinogen 3 in Acute Pancreatitis [Proteomics and Protein Markers] http://www.medworm.com/index.php?rid=5373690&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1506%3Frss%3D1 CONCLUSIONS: We established for the first time a specific immunoassay for trypsinogen 3 using monoclonal antibodies. Patients with AP were found to have increased serum concentrations of trypsinogen 3. The availability of this assay will be useful for studies of the clinical utility of trypsinogen 3. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373690 Fri, 28 Oct 2011 04:00:00 +0100 5373690 Carbamylation-Derived Products: Bioactive Compounds and Potential Biomarkers in Chronic Renal Failure and Atherosclerosis [Review] http://www.medworm.com/index.php?rid=5373689&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1499%3Frss%3D1 BACKGROUND: Carbamylation is a posttranslational modification of proteins resulting from the nonenzymatic reaction between isocyanic acid and specific free functional groups. This reaction alters protein structural and functional properties and thus contributes to molecular ageing. Many studies have shown the involvement of carbamylated proteins in diseases, especially in chronic renal failure and atherosclerosis. CONTENT: In this review we describe the biochemical basis of the carbamylation process and its role in protein molecular ageing. We summarize the current evidence of protein carbamylation involvement in disease, identify available biomarkers of the carbamylation process and their related analytical methods, and discuss the practical relevance of these biomarkers. SUMMARY: Carba... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373689 Fri, 28 Oct 2011 04:00:00 +0100 5373689 Avoiding Pitfalls in Applying Prediction Models, As Illustrated by the Example of Prostate Cancer Diagnosis [Mini-Review] http://www.medworm.com/index.php?rid=5373688&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1490%3Frss%3D1 BACKGROUND: The use of different mathematical models to support medical decisions is accompanied by increasing uncertainties when they are applied in practice. Using prostate cancer (PCa) risk models as an example, we recommend requirements for model development and draw attention to possible pitfalls so as to avoid the uncritical use of these models. CONTENT: We conducted MEDLINE searches for applications of multivariate models supporting the prediction of PCa risk. We critically reviewed the methodological aspects of model development and the biological and analytical variability of the parameters used for model development. In addition, we reviewed the role of prostate biopsy as the gold standard for confirming diagnoses. In addition, we analyzed different methods of model evaluation w... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373688 Fri, 28 Oct 2011 04:00:00 +0100 5373688 Commentary [Commentaries] http://www.medworm.com/index.php?rid=5373687&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1489%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373687 Fri, 28 Oct 2011 04:00:00 +0100 5373687 Unexplained Hemolytic Anemia with Multiorgan Failure [Clinical Case Study] http://www.medworm.com/index.php?rid=5373685&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1485%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373685 Fri, 28 Oct 2011 04:00:00 +0100 5373685 Circulating Cancer Cells and Their Clinical Applications [Q&A] http://www.medworm.com/index.php?rid=5373684&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1478%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373684 Fri, 28 Oct 2011 04:00:00 +0100 5373684 FGF23: Is It Ready for Prime Time? [Perspectives] http://www.medworm.com/index.php?rid=5373683&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1476%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373683 Fri, 28 Oct 2011 04:00:00 +0100 5373683 SPINK1: A New Therapeutic Target in Cancer? [Perspectives] http://www.medworm.com/index.php?rid=5373682&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1474%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373682 Fri, 28 Oct 2011 04:00:00 +0100 5373682 In Search for a Better Marker of Acute Pancreatitis--Third Time Lucky? [Editorial] http://www.medworm.com/index.php?rid=5373681&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F11%2F1471%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5373681 Fri, 28 Oct 2011 04:00:00 +0100 5373681 International Year of Chemistry 2011: Berzelius, Liebig, and the Infrastructure of Chemistry [Clinical Chemist] http://www.medworm.com/index.php?rid=5267859&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1468%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267859 Wed, 28 Sep 2011 04:00:00 +0100 5267859 Unveiling the Right Side [Clinical Chemist] http://www.medworm.com/index.php?rid=5267858&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1467%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267858 Wed, 28 Sep 2011 04:00:00 +0100 5267858 News & Views: Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and Postpartum [Clinical Chemist] http://www.medworm.com/index.php?rid=5267857&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1466%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267857 Wed, 28 Sep 2011 04:00:00 +0100 5267857 What Is Your Guess? Which Count Is Correct? [Clinical Chemist] http://www.medworm.com/index.php?rid=5267856&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1465%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267856 Wed, 28 Sep 2011 04:00:00 +0100 5267856 In Reply [Letters to the Editor] http://www.medworm.com/index.php?rid=5267855&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1463-a%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267855 Wed, 28 Sep 2011 04:00:00 +0100 5267855 The Consensus Statement on the Standardization and Evaluation of Growth Hormone and Insulin-like Growth Factor Assays Lacks a Recommendation to Attempt Efficacious Harmonization [Letters to the Editor] http://www.medworm.com/index.php?rid=5267854&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1463%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267854 Wed, 28 Sep 2011 04:00:00 +0100 5267854 Increased Serum Leptin Indicates Leptin Resistance in Obesity [Citation Classic] http://www.medworm.com/index.php?rid=5267853&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1461%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267853 Wed, 28 Sep 2011 04:00:00 +0100 5267853 Admission Proinsulin Is Associated with Mortality in Patients with Admission Hyperglycemia during Acute Coronary Syndrome: Results from a Pilot Observational Study [Brief Communications] http://www.medworm.com/index.php?rid=5267852&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F57%2F10%2F1456%3Frss%3D1 CONCLUSIONS: An increased proinsulin concentration may be a marker for mortality in ACS patients with hyperglycemia at admission and without known diabetes. Further studies are needed to evaluate the role of metabolic parameters such as proinsulin. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=5267852 Wed, 28 Sep 2011 04:00:00 +0100 5267852