MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Chemistry' source. Mon, 15 Mar 2010 16:25:09 +0100 http://www.medworm.com/index.php?rid=3314051&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F497%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314051 Fri, 26 Feb 2010 20:02:01 +0100 3314051 http://www.medworm.com/index.php?rid=3314050&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F496-a%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314050 Fri, 26 Feb 2010 20:02:01 +0100 3314050 http://www.medworm.com/index.php?rid=3314049&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F496%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314049 Fri, 26 Feb 2010 20:02:01 +0100 3314049 http://www.medworm.com/index.php?rid=3314048&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F495-a%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314048 Fri, 26 Feb 2010 20:02:00 +0100 3314048 http://www.medworm.com/index.php?rid=3314047&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F495%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314047 Fri, 26 Feb 2010 20:02:00 +0100 3314047 http://www.medworm.com/index.php?rid=3314046&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F494%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314046 Fri, 26 Feb 2010 20:02:00 +0100 3314046 http://www.medworm.com/index.php?rid=3314045&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F493%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314045 Fri, 26 Feb 2010 20:02:00 +0100 3314045 http://www.medworm.com/index.php?rid=3314044&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F492%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314044 Fri, 26 Feb 2010 20:02:00 +0100 3314044 http://www.medworm.com/index.php?rid=3314043&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F491%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314043 Fri, 26 Feb 2010 20:02:00 +0100 3314043 http://www.medworm.com/index.php?rid=3314042&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F489%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314042 Fri, 26 Feb 2010 20:02:00 +0100 3314042 http://www.medworm.com/index.php?rid=3314041&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F487%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314041 Fri, 26 Feb 2010 20:02:00 +0100 3314041 http://www.medworm.com/index.php?rid=3314040&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F485%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314040 Fri, 26 Feb 2010 20:02:00 +0100 3314040 http://www.medworm.com/index.php?rid=3314039&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F484%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314039 Fri, 26 Feb 2010 20:02:00 +0100 3314039 http://www.medworm.com/index.php?rid=3314038&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F482%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314038 Fri, 26 Feb 2010 20:02:00 +0100 3314038 http://www.medworm.com/index.php?rid=3314037&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F478%3Frss%3D1 Conclusions: CRP is recognized by SR-A as well as LOX-1 and taken up via SR-A in a macrophage-like cell line. This process might be of significance in the pathogenesis of atherosclerotic disease. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314037 Fri, 26 Feb 2010 20:02:00 +0100 3314037 http://www.medworm.com/index.php?rid=3314036&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F474%3Frss%3D1 Conclusions: The CKD-EPI equation shows improved estimation ability, and we recommend that it replace the MDRD Study equation as the currently preferred creatinine-based estimating equation for KTRs. The precision of GFR estimates obtained with the CKD-EPI equation remains suboptimal, however, and we recommend that research on other markers of GFR, such as cystatin C and β-trace protein, be pursued. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314036 Fri, 26 Feb 2010 20:02:00 +0100 3314036 http://www.medworm.com/index.php?rid=3314035&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F469%3Frss%3D1 Conclusions: These single-step, closed-tube assays specifically target mutations associated with resistance to dasatinib or nilotinib. Compared with standard genotyping, such biased genotyping improves the detection of resistance or alternative features via quantitative analysis of the absolute amount of resistance. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314035 Fri, 26 Feb 2010 20:02:00 +0100 3314035 http://www.medworm.com/index.php?rid=3314034&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F464%3Frss%3D1 Conclusions: IgG-anti-dGli and IgG-anti-tTG have comparable diagnostic sensitivities for IgA-deficient celiac patients. IgG-anti-dGli may be useful for diagnosing CD in IgA-deficient patients. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314034 Fri, 26 Feb 2010 20:02:00 +0100 3314034 http://www.medworm.com/index.php?rid=3314033&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F459%3Frss%3D1 Conclusions: Massively parallel sequencing-by-ligation of maternal plasma DNA was effective in identifying T21 fetuses noninvasively. The quantitative biases observed among the GRs of certain chromosomes were more likely based on analytical factors than biological factors. Further research is needed to enhance the precision for measuring for the representations of chromosomes 18 and 13. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314033 Fri, 26 Feb 2010 20:02:00 +0100 3314033 http://www.medworm.com/index.php?rid=3314032&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F451%3Frss%3D1 Conclusions: MBP, GFAP, S100B, and NSE display relevant differences in cellular and subcellular origins, which are reflected in their relation to stroke characteristics. MBP is a marker for infarct location. GFAP and S100B correlate with stroke severity and outcome. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314032 Fri, 26 Feb 2010 20:02:00 +0100 3314032 http://www.medworm.com/index.php?rid=3314031&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F445%3Frss%3D1 Conclusions: These data indicate that the multiplex method with specificity for 2 isoforms of IRT has performance comparable to that of a standard IRT method and the advantage of improved standardization by detection of the 2 isoforms. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314031 Fri, 26 Feb 2010 20:02:00 +0100 3314031 http://www.medworm.com/index.php?rid=3314030&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F437%3Frss%3D1 Conclusions: Use of a GALT cutoff of ≤40 µmol/L/L and a Gal cutoff of ≥1.665 mmol/L (≥30 mg/dL) for urgent notification/referral dramatically reduces false positives and unnecessary follow-up, thereby reducing the stress on healthcare resources. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314030 Fri, 26 Feb 2010 20:02:00 +0100 3314030 http://www.medworm.com/index.php?rid=3314029&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F432%3Frss%3D1 Conclusions: Our data demonstrate that CNCbl is absorbed unchanged and accumulates on circulating TC. We suggest that measuring TC–CNCbl will improve the assessment of vitamin B12 absorption. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314029 Fri, 26 Feb 2010 20:02:00 +0100 3314029 http://www.medworm.com/index.php?rid=3314028&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F424%3Frss%3D1 Conclusions: These results confirm the validity of the assay as a high-throughput screening method for mitochondrial function in digitonin-permeabilized cells. The assay allows primary and secondary mitochondrial abnormalities in muscle to be differentiated, which is of great importance with respect to counseling, and also will facilitate the search for new genetic defects that lead to mitochondrial disease. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314028 Fri, 26 Feb 2010 20:02:00 +0100 3314028 http://www.medworm.com/index.php?rid=3314027&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F417%3Frss%3D1 Conclusions: We improved laboratory efficiency and physician communication by developing an electronic system for reporting of critical values that is in compliance with The Joint Commission’s goals. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314027 Fri, 26 Feb 2010 20:02:00 +0100 3314027 http://www.medworm.com/index.php?rid=3314026&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F409%3Frss%3D1 Conclusions: Comparative genomic salivary analyses provide robust, comprehensive, real-time information regarding nearly all organs and tissues in the developing preterm infant. This innovative and noninvasive technique represents a new approach for monitoring health, disease, and development in this vulnerable patient population. By comparing these data in healthy infants with data from infants who develop medical complications, we expect to identify new biomarkers that will ultimately improve newborn care. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314026 Fri, 26 Feb 2010 20:02:00 +0100 3314026 http://www.medworm.com/index.php?rid=3314025&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F399%3Frss%3D1 Conclusions: The novel PCR technology can accurately categorize the spectrum of FMR1 alleles, including alleles previously considered too large to amplify; reproducibly detect low abundance full mutation alleles; and correctly infer homozygosity in female samples, thus greatly reducing the need for sample reflexing to Southern blotting. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314025 Fri, 26 Feb 2010 20:02:00 +0100 3314025 http://www.medworm.com/index.php?rid=3314024&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F391%3Frss%3D1 Conclusions: The introduction of this assay into clinical practice could provide useful information for the diagnosis and possibly for the prognosis and treatment of thyroid cancer in the future. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314024 Fri, 26 Feb 2010 20:01:59 +0100 3314024 http://www.medworm.com/index.php?rid=3314023&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F388%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314023 Fri, 26 Feb 2010 20:01:59 +0100 3314023 http://www.medworm.com/index.php?rid=3314022&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F376%3Frss%3D1 Background: Over the last 10 years, DNA microarrays have achieved a robust analytical performance, enabling their use for analyzing the whole transcriptome or for screening thousands of single-nucleotide polymorphisms in a single experiment. DNA microarrays allow scientists to correlate gene expression signatures with disease progression, to screen for disease-specific mutations, and to treat patients according to their individual genetic profiles; however, the real key is proteins and their manifold functions. It is necessary to achieve a greater understanding of not only protein function and abundance but also their role in the development of diseases. Protein concentrations have been shown to reflect the physiological and pathologic state of an organ, tissue, or cells far more directly ... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314022 Fri, 26 Feb 2010 20:01:59 +0100 3314022 http://www.medworm.com/index.php?rid=3314021&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F361%3Frss%3D1 Background: Early identification of pregnant women at risk for preeclampsia is a priority to implement preventive measures. Some biochemical and ultrasonographic parameters have shown promising predictive performance, but so far there is no clinically validated screening procedure. Content: Using a series of keywords, we reviewed electronic databases (Medline, Embase, all records to May 2009) reporting the performance of biological and ultrasonographic markers to predict preeclampsia, both single markers and combinations of markers. We analyzed the data according to gestational age and risk levels of the studied populations. We evaluated the methodological quality of included publications using QUADAS (quality assessment of diagnostic accuracy studies). We identified 37 relevant studies th... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314021 Fri, 26 Feb 2010 20:01:59 +0100 3314021 http://www.medworm.com/index.php?rid=3314020&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F357%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314020 Fri, 26 Feb 2010 20:01:59 +0100 3314020 http://www.medworm.com/index.php?rid=3314019&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F356%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314019 Fri, 26 Feb 2010 20:01:59 +0100 3314019 http://www.medworm.com/index.php?rid=3314018&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F355%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314018 Fri, 26 Feb 2010 20:01:59 +0100 3314018 http://www.medworm.com/index.php?rid=3314017&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F352%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314017 Fri, 26 Feb 2010 20:01:59 +0100 3314017 http://www.medworm.com/index.php?rid=3314016&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F345%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314016 Fri, 26 Feb 2010 20:01:59 +0100 3314016 http://www.medworm.com/index.php?rid=3314015&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F342%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314015 Fri, 26 Feb 2010 20:01:59 +0100 3314015 http://www.medworm.com/index.php?rid=3314014&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F339%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314014 Fri, 26 Feb 2010 20:01:59 +0100 3314014 http://www.medworm.com/index.php?rid=3314013&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F336%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314013 Fri, 26 Feb 2010 20:01:59 +0100 3314013 http://www.medworm.com/index.php?rid=3314012&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F334%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314012 Fri, 26 Feb 2010 20:01:59 +0100 3314012 http://www.medworm.com/index.php?rid=3314011&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F3%2F331%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3314011 Fri, 26 Feb 2010 20:01:59 +0100 3314011 http://www.medworm.com/index.php?rid=3219650&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F327%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219650 Thu, 28 Jan 2010 20:01:59 +0100 3219650 http://www.medworm.com/index.php?rid=3219649&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F321%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219649 Thu, 28 Jan 2010 20:01:59 +0100 3219649 http://www.medworm.com/index.php?rid=3219648&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F319%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219648 Thu, 28 Jan 2010 20:01:58 +0100 3219648 http://www.medworm.com/index.php?rid=3219647&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F314%3Frss%3D1 Conclusions: The MULTI-ARRAY and Bio-Plex multiplex immunoassay systems are the most suitable for biomarker analysis or quantification. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219647 Thu, 28 Jan 2010 20:01:58 +0100 3219647 http://www.medworm.com/index.php?rid=3219646&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F306%3Frss%3D1 Conclusions: In patients with hyperparathyroidism, the immunocapture in situ digestion LC-MS/MS method can provide accurate and precise PTH results compared with immunoassay. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219646 Thu, 28 Jan 2010 20:01:58 +0100 3219646 http://www.medworm.com/index.php?rid=3219645&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F291%3Frss%3D1 Conclusions: This algorithm for automated detection of inaccurate and imprecise transitions (AuDIT) in MRM-MS data reduces the time required for manual and subjective inspection of data, improves the overall accuracy of data analysis, and is easily implemented into the standard data-analysis work flow. AuDIT currently works with results exported from MRM-MS data-processing software packages and may be implemented as an analysis tool within such software. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219645 Thu, 28 Jan 2010 20:01:58 +0100 3219645 http://www.medworm.com/index.php?rid=3219644&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F281%3Frss%3D1 Conclusions: Mass spectrometric immunoassays identified new clinical variants of PTH and provided a quantitative assay for these and previously identified forms of PTH. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219644 Thu, 28 Jan 2010 20:01:58 +0100 3219644 http://www.medworm.com/index.php?rid=3219643&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F272%3Frss%3D1 Conclusions: The introduction of a few structural key elements (affinity tags, linkers, d-amino acids) into synthetic reporter peptides increases the diagnostic sensitivity for MS-based protease profiling of serum specimens. This new approach might lead to functional MS-based protease profiling for improved disease classification. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219643 Thu, 28 Jan 2010 20:01:58 +0100 3219643 http://www.medworm.com/index.php?rid=3219642&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F262%3Frss%3D1 Conclusions: For ovarian cancer, altered MALDI-TOF MS peptide profiles alone cannot be used for accurate diagnoses. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219642 Thu, 28 Jan 2010 20:01:58 +0100 3219642 http://www.medworm.com/index.php?rid=3219641&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F254%3Frss%3D1 Conclusions: The analytical performance of hs-cTnT complies with the ESC-ACCF-AHA-WHF Global Task Force recommendations for use in the diagnosis of MI. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219641 Thu, 28 Jan 2010 20:01:58 +0100 3219641 http://www.medworm.com/index.php?rid=3219640&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F248%3Frss%3D1 Conclusions: CSF biomarkers Aβ42 and Tau can be used as a diagnostic aid in AD. pTau did not have additional value over these 2 markers. Cutoff values, sensitivities, specificities, and discrimination lines depend on the patient groups studied and laboratory experience. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219640 Thu, 28 Jan 2010 20:01:58 +0100 3219640 http://www.medworm.com/index.php?rid=3219639&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F244%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219639 Thu, 28 Jan 2010 20:01:58 +0100 3219639 http://www.medworm.com/index.php?rid=3219638&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F237%3Frss%3D1 Clinical proteomics has the potential to enable the early detection of cancer through the development of multiplex assays that can inform clinical decisions. However, there has been some uncertainty among translational researchers and developers as to the specific analytical measurement criteria needed to validate protein-based multiplex assays. To begin to address the causes of this uncertainty, a day-long workshop titled "Interagency Oncology Task Force Molecular Diagnostics Workshop" was held in which members of the proteomics and regulatory communities discussed many of the analytical evaluation issues that the field should address in development of protein-based multiplex assays for clinical use. This meeting report explores the issues raised at the workshop and details the recommenda... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219638 Thu, 28 Jan 2010 20:01:58 +0100 3219638 http://www.medworm.com/index.php?rid=3219637&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F223%3Frss%3D1 We present the biological relevance of glycosylation to disease progression by highlighting the role these structures play in adhesion, signaling, and metastasis and then address current methodological approaches to biomarker discovery that capitalize on selectively capturing tumor-associated glycoforms to enrich and identify disease-related candidate analytes. Finally, we discuss emerging technologies—multiple reaction monitoring and lectin-antibody arrays—as potential tools for biomarker validation studies in pursuit of clinically useful tests. Summary: The future of carbohydrate-based biomarker studies has arrived. At all stages, from discovery through verification and deployment into clinics, glycosylation should be considered a primary readout or a way of increasing the se... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219637 Thu, 28 Jan 2010 20:01:58 +0100 3219637 http://www.medworm.com/index.php?rid=3219636&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F212%3Frss%3D1 Background: Although robust discovery-phase platforms have resulted in the generation of large numbers of candidate cancer biomarkers, a comparable system for subsequent quantitative assessment and verification of all candidates is lacking. Established immunoassays and available antibodies permit analysis of small subsets of candidates; however, the lack of commercially available reagents, coupled with high costs and lengthy production and purification times, have rendered the large majority of candidates untestable. Content: Mass spectrometry (MS), and in particular multiple reaction monitoring (MRM)-MS, has emerged as an alternative technology to immunoassays for quantification of target proteins. Novel biomarkers are expected to be present in serum in the low (µg/L–ng/L) ran... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219636 Thu, 28 Jan 2010 20:01:58 +0100 3219636 http://www.medworm.com/index.php?rid=3219635&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F202%3Frss%3D1 We describe and explore the implications of microheterogeneity using the exemplar of human vitamin D binding protein (Gc-Globulin) as observed in cohorts of 400 individuals. Our investigations yielded: (a) population frequency data comparable to genotyping; (b) population frequency data for protein variants, with and without genotype linkage; (c) reference values for the different protein variants per cohort and genotype; and (d) associations between variant, frequency, relative abundance, and diseases. Summary: With the exception of the genotype frequency, such population data are unique and illustrate a need to more fully understand the exact full-length qualitative and quantitative idiosyncrasies of individual proteins in relation to health and disease as part of the standardized biomar... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219635 Thu, 28 Jan 2010 20:01:58 +0100 3219635 http://www.medworm.com/index.php?rid=3219634&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F194%3Frss%3D1 Conclusions: There remain important unmet diagnostic and prognostic needs in cardiology. Advances in technology may allow proteomics to play a vital role in the discovery and validation of novel biomarkers to help fill those needs. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219634 Thu, 28 Jan 2010 20:01:58 +0100 3219634 http://www.medworm.com/index.php?rid=3219633&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F186%3Frss%3D1 Background: The measurement of multiple protein biomarkers may refine risk stratification in clinical settings. This concept has stimulated development of multiplexed immunoassay platforms that provide multiple, parallel protein measurements on the same specimen. Content: We provide an overview of antibody-based multiplexed immunoassay platforms and discuss technical and operational challenges. Multiplexed immunoassays use traditional immunoassay principles in which high-affinity capture ligands are immobilized in parallel arrays in either planar format or on microspheres in suspension. Development of multiplexed immunoassays requires rigorous validation of assay configuration and analytical performance to minimize assay imprecision and inaccuracy. Challenges associated with multiplex conf... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219633 Thu, 28 Jan 2010 20:01:58 +0100 3219633 http://www.medworm.com/index.php?rid=3219632&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F177%3Frss%3D1 An analysis of all US Food and Drug Administration (FDA) approvals for protein-based assays through 2008 reveals 109 unique protein targets in plasma or serum, as well as 62 additional tests for peptides, protein posttranslational modifications, protein complexes, autoantibodies against endogenous proteins, and blood cell proteins. A further 96 unique protein targets are assayed in plasma by laboratory-developed tests available for clinical use in the US, yielding a total of 205 proteins that include products of approximately 211 genes (excluding immunoglobulins). These tests provide quantitative measurements for approximately 1% of the human protein gene products, defining a practical clinical plasma proteome. The rate of introduction of new protein analytes has remained essentially flat ... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219632 Thu, 28 Jan 2010 20:01:58 +0100 3219632 http://www.medworm.com/index.php?rid=3219631&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F172%3Frss%3D1 Conclusions: If the fundamental data that will be analyzed are not strong, then better analytic methods have limited use in improving the situation. Recognition of this situation is an important first step toward improving the quality of clinical research about markers to detect cancer. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219631 Thu, 28 Jan 2010 20:01:58 +0100 3219631 http://www.medworm.com/index.php?rid=3219630&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F165%3Frss%3D1 The objective was to evaluate the analytical measurement criteria and studies needed to validate protein-based multiplex assays. Each submission described a different protein-based platform: a multiplex immunoaffinity mass spectrometry platform for protein quantification, and an immunological array platform quantifying glycoprotein isoforms. Submissions provided a mutually beneficial way for members of the proteomics and regulatory communities to identify the analytical issues that the field should address when developing protein-based multiplex clinical assays. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219630 Thu, 28 Jan 2010 20:01:57 +0100 3219630 http://www.medworm.com/index.php?rid=3219629&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F161%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219629 Thu, 28 Jan 2010 20:01:57 +0100 3219629 http://www.medworm.com/index.php?rid=3219628&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F154%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219628 Thu, 28 Jan 2010 20:01:57 +0100 3219628 http://www.medworm.com/index.php?rid=3219627&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F152%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219627 Thu, 28 Jan 2010 20:01:57 +0100 3219627 http://www.medworm.com/index.php?rid=3219626&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F2%2F149%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3219626 Thu, 28 Jan 2010 20:01:57 +0100 3219626 http://www.medworm.com/index.php?rid=3128629&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F148%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128629 Tue, 29 Dec 2009 18:01:54 +0100 3128629 http://www.medworm.com/index.php?rid=3128628&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F146%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128628 Tue, 29 Dec 2009 18:01:54 +0100 3128628 http://www.medworm.com/index.php?rid=3128627&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F144%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128627 Tue, 29 Dec 2009 18:01:54 +0100 3128627 http://www.medworm.com/index.php?rid=3128626&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F143%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128626 Tue, 29 Dec 2009 18:01:54 +0100 3128626 http://www.medworm.com/index.php?rid=3128625&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F140-a%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128625 Tue, 29 Dec 2009 18:01:54 +0100 3128625 http://www.medworm.com/index.php?rid=3128624&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F140%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128624 Tue, 29 Dec 2009 18:01:54 +0100 3128624 http://www.medworm.com/index.php?rid=3128623&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F139%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128623 Tue, 29 Dec 2009 18:01:53 +0100 3128623 http://www.medworm.com/index.php?rid=3128622&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F136%3Frss%3D1 Conclusions: The use of short PCR amplicons improves the detection of cell-free fetal DNA. This feature may prove useful in attempts to detect cell-free fetal DNA under conditions in which the amount of template is low, such as in samples obtained early in pregnancy. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128622 Tue, 29 Dec 2009 18:01:53 +0100 3128622 http://www.medworm.com/index.php?rid=3128621&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F132%3Frss%3D1 Conclusions: hsCRP >10 mg/L was a stronger predictor of clinical events than a conventional cut point of 3 mg/L. Very highly increased hsCRP may provide clinically meaningful prognostic information. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128621 Tue, 29 Dec 2009 18:01:53 +0100 3128621 http://www.medworm.com/index.php?rid=3128620&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F127%3Frss%3D1 Conclusions: In this first study of proteomic biomarkers of TCC exercise, we found an increase in complement factor H associated with a decrease in complement factor B. Complement factor H is involved in protection from microangiopathy and macular degeneration and may represent a useful marker of the health effects of exercise. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128620 Tue, 29 Dec 2009 18:01:53 +0100 3128620 http://www.medworm.com/index.php?rid=3128619&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F121%3Frss%3D1 Conclusions: In pharmacologically unstable chronic HF patients, baseline values and follow-up measures of copeptin, midregional proadrenomedullin, C-terminal endothelin-1 precursor fragment, midregional proatrial natriuretic peptide, and B-type natriuretic peptide were equally predictive of all-cause mortality. Relative change of neurohormone values was noncontributory. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128619 Tue, 29 Dec 2009 18:01:53 +0100 3128619 http://www.medworm.com/index.php?rid=3128618&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F111%3Frss%3D1 Conclusions: ADMA varies nearly 2-fold across a healthy sample of older men and women, correlates with age, body mass index, and renal function, and is different across ethnic groups. Additional studies in a wider age range and including larger ethnic subgroups would be useful. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128618 Tue, 29 Dec 2009 18:01:53 +0100 3128618 http://www.medworm.com/index.php?rid=3128617&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F99%3Frss%3D1 Conclusions: The combination of in situ PLA with bright-field detection and automated image analysis allows the signals present to be counted in an automated fashion and thus provides a sensitive and specific method for quantification of proteins and protein complexes with bright-field microscopy. With this approach, in situ PLA can be used without the requirement for expensive fluorescence microscopes, thereby avoiding problems with nonspecific fluorescence while maintaining compatibility with conventional histologic staining. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128617 Tue, 29 Dec 2009 18:01:53 +0100 3128617 http://www.medworm.com/index.php?rid=3128616&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F90%3Frss%3D1 Conclusions: The epigenetic–genetic chromosome-dosage approach is a new method for noninvasive prenatal detection of T21. The epigenetic part of the analysis can be applied to all pregnancies. Because the genetic part of the analysis uses paternally inherited, fetal-specific genetic markers that are abundant in the genome, broad population coverage should be readily achievable. This approach has the potential to become a generally usable technique for noninvasive prenatal diagnosis. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128616 Tue, 29 Dec 2009 18:01:53 +0100 3128616 http://www.medworm.com/index.php?rid=3128615&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F82%3Frss%3D1 Conclusions: ALB mRNA is liver specific in plasma, but not in whole blood. Plasma ALB mRNA is increased in some liver pathologies and may be more diagnostically sensitive than -fetoprotein and ALT. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128615 Tue, 29 Dec 2009 18:01:53 +0100 3128615 http://www.medworm.com/index.php?rid=3128614&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F73%3Frss%3D1 Conclusions: For prenatal screening of trisomy 21, the quantification of the total PLAC4 mRNA concentration can be used in a synergistic manner with the RNA-SNP allelic ratio approach to increase the population coverage of cases in which diagnostic information can be obtained. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128614 Tue, 29 Dec 2009 18:01:53 +0100 3128614 http://www.medworm.com/index.php?rid=3128613&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F62%3Frss%3D1 Conclusions: We used a clinically relevant complex genomic target to evaluate a microarray-based sample-enrichment process and an NGS instrument for clinical resequencing purposes. The results allowed us to develop a systematic data-analysis strategy and algorithm to fit potential clinical applications. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128613 Tue, 29 Dec 2009 18:01:53 +0100 3128613 http://www.medworm.com/index.php?rid=3128612&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F53%3Frss%3D1 Conclusions: Our data support a nonpathogenic role for the BRCA1 c.591C>T variant. Naturally occurring alternative splicing isoforms need to be considered when assessing the role of BRCA1 UVs on splicing. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128612 Tue, 29 Dec 2009 18:01:53 +0100 3128612 http://www.medworm.com/index.php?rid=3128611&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F44%3Frss%3D1 Conclusions: Only the Afinion and the DCA Vantage met the acceptance criteria of having a total CV <3% in the clinically relevant range. The EP-9 results and the calculations of the NGSP certification showed significant differences in analytical performance between different reagent lot numbers for all Hb A1c POC instruments. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128611 Tue, 29 Dec 2009 18:01:53 +0100 3128611 http://www.medworm.com/index.php?rid=3128610&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F34%3Frss%3D1 Conclusions: Higher prediagnostic adiponectin (but not leptin) concentrations predispose men to a lower risk of developing high-grade prostate cancer and a lower risk of subsequently dying from the cancer, suggesting a mechanistic link between obesity and poor prostate cancer outcome. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128610 Tue, 29 Dec 2009 18:01:53 +0100 3128610 http://www.medworm.com/index.php?rid=3128609&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F21%3Frss%3D1 Background: Stroke is a devastating condition encompassing a wide range of pathophysiological entities that include thrombosis, hemorrhage, and embolism. Current diagnosis of stroke relies on physician clinical examination and is further supplemented with various neuroimaging techniques. A single set or multiple sets of blood biomarkers that could be used in an acute setting to diagnosis stroke, differentiate between stroke types, or even predict an initial/reoccurring stroke would be extremely valuable. Content: We discuss the current classification, diagnosis, and treatment of stroke, focusing on use of novel biomarkers (either solitary markers or multiple markers within a panel) that have been studied in a variety of clinical settings. Summary: The current diagnosis of stroke remains ha... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128609 Tue, 29 Dec 2009 18:01:53 +0100 3128609 http://www.medworm.com/index.php?rid=3128608&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F19-a%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128608 Tue, 29 Dec 2009 18:01:53 +0100 3128608 http://www.medworm.com/index.php?rid=3128607&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F19%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128607 Tue, 29 Dec 2009 18:01:53 +0100 3128607 http://www.medworm.com/index.php?rid=3128606&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F16%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128606 Tue, 29 Dec 2009 18:01:53 +0100 3128606 http://www.medworm.com/index.php?rid=3128605&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F10%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128605 Tue, 29 Dec 2009 18:01:53 +0100 3128605 http://www.medworm.com/index.php?rid=3128604&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F7%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128604 Tue, 29 Dec 2009 18:01:53 +0100 3128604 http://www.medworm.com/index.php?rid=3128603&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F4%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128603 Tue, 29 Dec 2009 18:01:53 +0100 3128603 http://www.medworm.com/index.php?rid=3128602&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F56%2F1%2F1%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3128602 Tue, 29 Dec 2009 18:01:52 +0100 3128602 http://www.medworm.com/index.php?rid=3035571&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2240%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035571 Fri, 27 Nov 2009 18:02:11 +0100 3035571 http://www.medworm.com/index.php?rid=3035570&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2238%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035570 Fri, 27 Nov 2009 18:02:11 +0100 3035570 http://www.medworm.com/index.php?rid=3035569&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2236%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035569 Fri, 27 Nov 2009 18:02:11 +0100 3035569 http://www.medworm.com/index.php?rid=3035568&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2235%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035568 Fri, 27 Nov 2009 18:02:11 +0100 3035568 http://www.medworm.com/index.php?rid=3035567&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2233%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035567 Fri, 27 Nov 2009 18:02:11 +0100 3035567 http://www.medworm.com/index.php?rid=3035566&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2232%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035566 Fri, 27 Nov 2009 18:02:11 +0100 3035566 http://www.medworm.com/index.php?rid=3035565&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2230%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035565 Fri, 27 Nov 2009 18:02:11 +0100 3035565 http://www.medworm.com/index.php?rid=3035564&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2229%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035564 Fri, 27 Nov 2009 18:02:11 +0100 3035564 http://www.medworm.com/index.php?rid=3035563&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2228%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035563 Fri, 27 Nov 2009 18:02:11 +0100 3035563 http://www.medworm.com/index.php?rid=3035562&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2227%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035562 Fri, 27 Nov 2009 18:02:11 +0100 3035562 http://www.medworm.com/index.php?rid=3035561&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2226%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035561 Fri, 27 Nov 2009 18:02:11 +0100 3035561 http://www.medworm.com/index.php?rid=3035560&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2225%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035560 Fri, 27 Nov 2009 18:02:11 +0100 3035560 http://www.medworm.com/index.php?rid=3035559&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2223%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035559 Fri, 27 Nov 2009 18:02:11 +0100 3035559 http://www.medworm.com/index.php?rid=3035558&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2218%3Frss%3D1 Conclusions: Facing the emergence of novel influenza A/H1N1/09, we were able to develop, within 2 days, a set of sensitive and specific RT-qPCR assays for the laboratory diagnosis of suspected cases. H1N1/09 served as a model to show the feasibility of the UPL approach for the expedited development of new diagnostic assays to detect emerging pathogens. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035558 Fri, 27 Nov 2009 18:02:11 +0100 3035558 http://www.medworm.com/index.php?rid=3035557&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2214%3Frss%3D1 Conclusions: AF-DE analysis is of value for prenatal CF diagnosis in classic forms of CF and could be helpful in nonclassic CF. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035557 Fri, 27 Nov 2009 18:02:11 +0100 3035557 http://www.medworm.com/index.php?rid=3035556&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2207%3Frss%3D1 Conclusions: The wide ranges of SUAC concentrations reported for pilot and proficiency testing specimens demonstrate a need to harmonize quantitative results among laboratories. Although DBS matrix calibrators are important for optimizing SUAC recoveries, the preparation of these calibrators is not standardized among laboratories. Certified DBS-based SUAC calibrators are needed for accuracy and harmonization. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035556 Fri, 27 Nov 2009 18:02:11 +0100 3035556 http://www.medworm.com/index.php?rid=3035555&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2198%3Frss%3D1 Conclusions: Identified determinants accounted for <17% of the overall variation in plasma MMA. The difference in MMA between middle-aged and elderly individuals is only partly explained by creatinine and vitamin B12 concentrations. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035555 Fri, 27 Nov 2009 18:02:11 +0100 3035555 http://www.medworm.com/index.php?rid=3035554&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2190%3Frss%3D1 Conclusions: There is inadequate evidence evaluating the use of uMb as a predictor of ARF in patients with suspected rhabdomyolysis. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035554 Fri, 27 Nov 2009 18:02:11 +0100 3035554 http://www.medworm.com/index.php?rid=3035553&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2180%3Frss%3D1 Conclusions: Plasma THC concentrations remained >1 µg/L for at least 1 day after daily cannabis smoking and also after cessation of multiple oral THC doses. We report for the first time free plasma THC concentrations after multiple high-dose oral THC throughout the day and night, and after Escherichia coli β-glucuronidase hydrolysis. These data will aid in the interpretation of plasma THC concentrations after multiple oral doses. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035553 Fri, 27 Nov 2009 18:02:10 +0100 3035553 http://www.medworm.com/index.php?rid=3035552&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2171%3Frss%3D1 Conclusions: Adult human CSF has sPLA2 activity that can be measured reliably with the assay described. This enzyme activity in the CSF is independent of both sex and age and might serve as a valuable biomarker of neuroinflammation, as we demonstrated in Alzheimer disease. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035552 Fri, 27 Nov 2009 18:02:10 +0100 3035552 http://www.medworm.com/index.php?rid=3035551&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2162%3Frss%3D1 Conclusions: We demonstrate an accurate method for transcription profiling of individual hESCs. Cell-to-cell variability is large and is at least partly nonrandom because we observed correlations between core transcription factors. High fluctuations in gene expression may explain why individual cells in a seemingly undifferentiated cell population have different susceptibilities for inductive cues. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035551 Fri, 27 Nov 2009 18:02:10 +0100 3035551 http://www.medworm.com/index.php?rid=3035550&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2153%3Frss%3D1 Conclusions: The loss-of-function p.R46L variant is associated with the expected lower concentrations of circulating PCSK9; the gain-of-function p.D374Y mutation is also associated with lower concentrations, presumably because of the higher affinity of this variant for the LDL receptor and its more rapid clearance. In treated FH patients, a low plasma PCSK9 concentration does not appear to be a useful screening tool for identifying novel PCSK9 mutations. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035550 Fri, 27 Nov 2009 18:02:10 +0100 3035550 http://www.medworm.com/index.php?rid=3035549&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2144%3Frss%3D1 Conclusions: The microdevice we have described has the potential to open new perspectives in noninvasive prenatal diagnosis by facilitating the isolation of fetal DNA from maternal plasma in an integrated, inexpensive, and easy-to-use microsystem. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035549 Fri, 27 Nov 2009 18:02:10 +0100 3035549 http://www.medworm.com/index.php?rid=3035548&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2130%3Frss%3D1 Conclusions: COLD-PCR/HRM improves the mutation-scanning capabilities of HRM and combines high selectivity, convenience, and low cost with the ability to sequence unknown low-level mutations in clinical samples. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035548 Fri, 27 Nov 2009 18:02:10 +0100 3035548 http://www.medworm.com/index.php?rid=3035547&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2121%3Frss%3D1 Conclusions: DLA-based strain typing is a powerful technique with a resolution comparable to macrorestriction mapping with PFGE, but DLA is faster, more automated, and more reproducible. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035547 Fri, 27 Nov 2009 18:02:10 +0100 3035547 http://www.medworm.com/index.php?rid=3035546&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2113%3Frss%3D1 Conclusion: We demonstrated for the first time that hepatic SCD1 expression can be estimated noninvasively from routine blood samples by measuring the SCD1 activity index in fasting plasma VLDL. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035546 Fri, 27 Nov 2009 18:02:10 +0100 3035546 http://www.medworm.com/index.php?rid=3035545&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2098%3Frss%3D1 Background: Although cardiac troponin (cTn) is a cornerstone marker in the assessment and management of patients with acute coronary syndrome (ACS) and heart failure (HF), cTn is not diagnostically specific for any single myocardial disease process. This narrative review discusses increases in cTn that result from acute and chronic diseases, iatrogenic causes, and myocardial injury other than ACS and HF. Content: Increased cTn concentrations have been reported in cardiac, vascular, and respiratory disease and in association with infectious processes. In cases involving acute aortic dissection, cerebrovascular accident, treatment in an intensive care unit, and upper gastrointestinal bleeding, increased cTn predicts a longer time to diagnosis and treatment, increased length of hospital stay,... Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035545 Fri, 27 Nov 2009 18:02:10 +0100 3035545 http://www.medworm.com/index.php?rid=3035544&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2096%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035544 Fri, 27 Nov 2009 18:02:10 +0100 3035544 http://www.medworm.com/index.php?rid=3035543&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2093-a%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035543 Fri, 27 Nov 2009 18:02:10 +0100 3035543 http://www.medworm.com/index.php?rid=3035542&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2093%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035542 Fri, 27 Nov 2009 18:02:10 +0100 3035542 http://www.medworm.com/index.php?rid=3035541&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2088%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035541 Fri, 27 Nov 2009 18:02:10 +0100 3035541 http://www.medworm.com/index.php?rid=3035540&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2085%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035540 Fri, 27 Nov 2009 18:02:10 +0100 3035540 http://www.medworm.com/index.php?rid=3035539&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2082%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035539 Fri, 27 Nov 2009 18:02:10 +0100 3035539 http://www.medworm.com/index.php?rid=3035538&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2079%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035538 Fri, 27 Nov 2009 18:02:10 +0100 3035538 http://www.medworm.com/index.php?rid=3035537&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2077%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035537 Fri, 27 Nov 2009 18:02:10 +0100 3035537 http://www.medworm.com/index.php?rid=3035536&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2074%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035536 Fri, 27 Nov 2009 18:02:10 +0100 3035536 http://www.medworm.com/index.php?rid=3035535&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F12%2F2071%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=3035535 Fri, 27 Nov 2009 18:02:10 +0100 3035535 http://www.medworm.com/index.php?rid=2946351&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2069%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2946351 Wed, 28 Oct 2009 17:02:33 +0100 2946351 http://www.medworm.com/index.php?rid=2946350&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2068%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2946350 Wed, 28 Oct 2009 17:02:33 +0100 2946350 http://www.medworm.com/index.php?rid=2938005&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2069%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2938005 Wed, 28 Oct 2009 17:02:33 +0100 2938005 http://www.medworm.com/index.php?rid=2938004&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2068%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2938004 Wed, 28 Oct 2009 17:02:33 +0100 2938004 http://www.medworm.com/index.php?rid=2938003&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2066%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2938003 Wed, 28 Oct 2009 17:02:33 +0100 2938003 http://www.medworm.com/index.php?rid=2938002&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2064%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2938002 Wed, 28 Oct 2009 17:02:33 +0100 2938002 http://www.medworm.com/index.php?rid=2938001&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2062%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2938001 Wed, 28 Oct 2009 17:02:33 +0100 2938001 http://www.medworm.com/index.php?rid=2938000&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2061%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2938000 Wed, 28 Oct 2009 17:02:32 +0100 2938000 http://www.medworm.com/index.php?rid=2937999&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2059%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937999 Wed, 28 Oct 2009 17:02:32 +0100 2937999 http://www.medworm.com/index.php?rid=2937998&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2057%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937998 Wed, 28 Oct 2009 17:02:32 +0100 2937998 http://www.medworm.com/index.php?rid=2937997&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2055%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937997 Wed, 28 Oct 2009 17:02:32 +0100 2937997 http://www.medworm.com/index.php?rid=2937996&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2053%3Frss%3D1 (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937996 Wed, 28 Oct 2009 17:02:32 +0100 2937996 http://www.medworm.com/index.php?rid=2937995&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2049%3Frss%3D1 Conclusions: In men, variation in plasma PCSK9 concentration influences the catabolism of LDL apo B-100. This finding appears to be independent of obesity, insulin resistance, energy intake, and age. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937995 Wed, 28 Oct 2009 17:02:32 +0100 2937995 http://www.medworm.com/index.php?rid=2937994&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2040%3Frss%3D1 Conclusions: UII is secreted from the heart and multiple other tissues into the circulation. Related increments in UII immunoreactivity across multiple tissue sites suggest that peptide release occurs via a shared mechanism. Increased UII immunoreactivity is observed in subjects with acute coronary syndrome. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937994 Wed, 28 Oct 2009 17:02:32 +0100 2937994 http://www.medworm.com/index.php?rid=2937993&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2035%3Frss%3D1 Conclusions: Second-void fasting UCPCR is a reproducible measure that correlates well with 24-h UCP in normal samples. The 3-day stability of UCPCR at room temperature greatly increases its potential clinical utility. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937993 Wed, 28 Oct 2009 17:02:32 +0100 2937993 http://www.medworm.com/index.php?rid=2937992&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2026%3Frss%3D1 Conclusions: These data suggest a positive association between plasma uric acid and incidence of hypertension during short-term follow-up in a Chinese population. The association between hyperuricemia and hypertension was partly mediated by abdominal obesity. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937992 Wed, 28 Oct 2009 17:02:32 +0100 2937992 http://www.medworm.com/index.php?rid=2937991&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2019%3Frss%3D1 Conclusions: Conventional application of separate cutoff values for FT4 and TSH leads to overestimation of the incidence of subclinical thyroid disease. Application of a composite overall reference interval is recommended. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937991 Wed, 28 Oct 2009 17:02:32 +0100 2937991 http://www.medworm.com/index.php?rid=2937990&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F2004%3Frss%3D1 Conclusions: The UPLC-MS/MS method makes it possible to detect all 29 analytes in 1 chromatographic run (15 min), including -9-tetrahydrocannabinol and benzoylecgonine, which previously have been difficult to incorporate into multicomponent methods. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937990 Wed, 28 Oct 2009 17:02:32 +0100 2937990 http://www.medworm.com/index.php?rid=2937989&cid=s_32068_59_f&fid=32068&url=http%3A%2F%2Fwww.clinchem.org%2Fcgi%2Fcontent%2Fshort%2F55%2F11%2F1995%3Frss%3D1 Conclusions: The presented PWG platform demonstrated excellent sensitivity and precision and is especially well suited for any application for which fast, simple, and robust multiplex assays of RNA in FFPE tissue are required. (Source: Clinical Chemistry) Clinical Chemistry journals http://www.medworm.com/rss/comments.php?id=2937989 Wed, 28 Oct 2009 17:02:32 +0100 2937989