MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Endocrinology' source. Wed, 08 Feb 2012 15:08:50 +0100 http://www.medworm.com/index.php?rid=5644251&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2012.04353.x ConclusionBGC occurs in 73.8% of patients with IH and correlates with the duration of hypocalcaemia, choroid plexus calcification, seizures and cataract. Progression of BGC is related to the calcium‐phosphorus ratio during follow up. This brings forth the importance of adequate phosphorus control in the management of hypoparathyroidism.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5644251 Tue, 31 Jan 2012 19:54:07 +0100 5644251 http://www.medworm.com/index.php?rid=5627124&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2012.04348.x ConclusionGIL is associated with a different adipokine profile both before and after glucocorticoid therapy. Serum leptin level prior to glucocorticoid therapy is highly predictive of GIL occurrence.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5627124 Wed, 25 Jan 2012 20:35:25 +0100 5627124 http://www.medworm.com/index.php?rid=5607243&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2012.04343.x Conclusions:  In patients with DTC, Ki‐67 expression associates with tumour staging and clinical outcome.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5607243 Thu, 19 Jan 2012 23:24:06 +0100 5607243 http://www.medworm.com/index.php?rid=5580236&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2012.04337.x Conclusion:  Carotid IMT was abnormal in TS and negatively influenced by age, metabolic biomarkers, blood pressure and short duration of oestrogen treatment. Attention to common cardiovascular and endocrine risk markers over more than two years appeared to influence IMT beneficially.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5580236 Fri, 13 Jan 2012 06:48:06 +0100 5580236 http://www.medworm.com/index.php?rid=5568750&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04203.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568750 Sat, 07 Jan 2012 02:18:48 +0100 5568750 http://www.medworm.com/index.php?rid=5568749&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04204.x Conclusions  Radioiodine treatment with a calculated dose regimen is a highly effective treatment option in patients with toxic goitre with an overall success rate of 98%. However, radioiodine treatment with an intended thyroid dose of 150 Gy leads to a high incidence of hypothyroidism on long‐term follow‐up. This finding supports the suggestion that in future intended thyroid doses could be lowered in patients treated with a calculated dose regimen for toxic nodular goitre. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568749 Sat, 07 Jan 2012 02:18:45 +0100 5568749 http://www.medworm.com/index.php?rid=5568748&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04199.x Conclusions  The evaluation of thyroid nodules using the newer diagnostic methods was useful in identifying DTC early. Consequently, the reoperation and thyroid remnant ablation rates were reduced. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568748 Sat, 07 Jan 2012 02:18:43 +0100 5568748 http://www.medworm.com/index.php?rid=5568747&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04189.x Conclusions  Acute testosterone withdrawal reduces insulin sensitivity in men independent of changes in body weight, whereas estradiol withdrawal has no effect. Testosterone appears to maintain insulin sensitivity in normal men. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568747 Sat, 07 Jan 2012 02:18:41 +0100 5568747 http://www.medworm.com/index.php?rid=5568746&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04188.x Conclusions  While overall these data do not provide strong support for an association between NSAID use and hormone levels in men, prescription NSAIDs may decrease levels of certain oestrogens and androgens in obese and inactive men. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568746 Sat, 07 Jan 2012 02:18:39 +0100 5568746 http://www.medworm.com/index.php?rid=5568745&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04180.x Conclusions  In 13 newly described pregnancies along with systematic review of an additional 34 cases indicate that pregnancy in treated acromegalic women can proceed without significant complications or teratogenicity. Medical treatment during pregnancy with DA or SA appears to be associated with altered neonatal weight. Nevertheless, gestation may have a beneficial impact on acromegaly control both during and following pregnancy. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568745 Sat, 07 Jan 2012 02:18:38 +0100 5568745 http://www.medworm.com/index.php?rid=5568744&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04179.x Conclusions  We concluded that V2R was expressed on corticotrophinomas and that the level of its expression correlated well with the ACTH response to desmopressin in CD patients, although abundant expression of V1R and V3R was also found in almost all corticotroph tumours. Further studies are needed to elucidate the role of these receptors in the pathogenesis of CD. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568744 Sat, 07 Jan 2012 02:18:36 +0100 5568744 http://www.medworm.com/index.php?rid=5568743&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04174.x Conclusion  The current average HCeq dose of approximately 20 mg per day is not associated with an adverse metabolic profile, as compared with ACTHsuff patients with hypopituitarism. GC replacement in ACTHins women is independently associated with reduced BMD and higher prevalence of osteopenia. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568743 Sat, 07 Jan 2012 02:18:34 +0100 5568743 http://www.medworm.com/index.php?rid=5568742&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04173.x Conclusion  To our knowledge, this is the first study reporting the effect of CCHF on pituitary function. We found that cortisol insufficiency may occur in patients diagnosed with CCHF; however, studies including a larger number of patients are required to make a definite conclusion on this issue. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568742 Sat, 07 Jan 2012 02:18:32 +0100 5568742 http://www.medworm.com/index.php?rid=5568741&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04187.x Conclusions  Plasma CNP peptides are higher in children with hyperthyroidism than in those with hypothyroidism at diagnosis and, in hyperthyroid children, change concordantly with TH and HV during treatment. Differential responses of CNP in the two groups suggest CNP production is dependent on growth plate activity and not a direct effect of TH on CNP gene expression. Our findings suggest novel mechanisms underlying changes in skeletal response during treatment in children with acquired thyroid disease. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568741 Sat, 07 Jan 2012 02:18:29 +0100 5568741 http://www.medworm.com/index.php?rid=5568740&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04159.x Conclusions/interpretation  Defects in insulin secretion and action interact with body composition and gender to influence postchallenge glucose concentrations. There is considerable heterogeneity of insulin secretion and action for a given fasting glucose likely because of patient subsets with isolated IFG and normal glucose tolerance. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568740 Sat, 07 Jan 2012 02:18:25 +0100 5568740 http://www.medworm.com/index.php?rid=5568739&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04150.x Conclusions  Our results suggest that RBP4 levels might be associated with at least some olanzapine‐induced metabolic abnormalities and cardiovascular disease risk factors. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568739 Sat, 07 Jan 2012 02:18:24 +0100 5568739 http://www.medworm.com/index.php?rid=5568738&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04149.x Conclusions  Lower 25(OH)D is associated with higher serum insulin but not lipoatrophy or hypoadiponectinemia in HIV‐infected patients. The association between VDD and insulin resistance is likely to be mediated by independent mechanisms. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568738 Sat, 07 Jan 2012 02:18:22 +0100 5568738 http://www.medworm.com/index.php?rid=5568737&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04197.x Conclusions  Asymptomatic pHPT is associated with neuropsychological symptoms that improve after parathyroidectomy. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568737 Sat, 07 Jan 2012 02:18:20 +0100 5568737 http://www.medworm.com/index.php?rid=5568736&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04233.x SummaryAndrogen administration can cause prostate cancer progression, and androgen deprivation therapy is a commonly used therapeutic modality in the treatment of prostate cancer. In trying to answer the posed clinical question, this article reviews the risks and benefits of testosterone replacement therapy in this setting and the published data from clinical series. Recommendations are made based on the available evidence. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568736 Sat, 07 Jan 2012 02:18:15 +0100 5568736 http://www.medworm.com/index.php?rid=5568735&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04216.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568735 Sat, 07 Jan 2012 02:18:13 +0100 5568735 http://www.medworm.com/index.php?rid=5568734&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04238.x SummaryMagnetic resonance imaging (MRI) is the radiological examination method of choice for evaluating hypothalamo‐pituitary‐related endocrine disease and is considered essential in the assessment of patients with suspected hypothalamo‐pituitary pathology. Physicians involved in the care of such patients have, in MRI, a valuable tool that can aid them in determining the pathogenesis of their patients’ underlying pituitary conditions. Indeed, the use of MRI has led to an enormous increase in our knowledge of pituitary morphology, improving, in particular, the differential diagnosis of hypopituitarism. Specifically, MRI allows detailed and precise anatomical study of the pituitary gland by differentiating between the anterior and posterior pituitary lobes. MRI recognition of pituita... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568734 Sat, 07 Jan 2012 02:18:12 +0100 5568734 http://www.medworm.com/index.php?rid=5568733&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04235.x SummaryRathke’s cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke’s pouch. Although a common finding in routine autopsies (12–33% of normal pituitary glands), symptomatic cases are rare and comprise 5–15% of all surgically resected sellar lesions. Small, asymptomatic RCC do not require surgical intervention, and their natural history is not clear. In series of nonoperated presumed RCCs, 26–94% did not progress during follow‐up periods up to 9 years. In symptomatic ones, surgery is indicated, aiming to drain the cyst content and safely remove as much of the capsule as possible. Following surgical intervention, headaches and visual field defects improve or resolve in a significant number of patients (40–100% and 33–100%... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568733 Sat, 07 Jan 2012 02:18:10 +0100 5568733 http://www.medworm.com/index.php?rid=5568730&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2012.04329.x Conclusions:  These results suggest that apoB/A1 ratio is independently associated with MetS and that an apoB/A1 ratio greater than 0.65 in men and 0.62 in women is a marker of MetS independent from conventional risk factors© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568730 Sat, 07 Jan 2012 02:18:05 +0100 5568730 http://www.medworm.com/index.php?rid=5568732&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2012.04330.x Conclusions:  Perceived benefits for retaining gonads in women with CAIS are prompting more women to keep their gonads in situ. An accurate estimate for adult malignancy risk is unavailable and the risks currently quoted may be falsely reassuring.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568732 Mon, 02 Jan 2012 05:00:00 +0100 5568732 http://www.medworm.com/index.php?rid=5568731&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2012.04332.x Conclusion:  This study supports previously reported positive associations between vitamin D and testosterone although we did not observe parallel seasonal variation patterns. Possible causality and direction of the vitamin D‐testosterone association deserve further scientific investigation.© 2012 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5568731 Mon, 02 Jan 2012 05:00:00 +0100 5568731 http://www.medworm.com/index.php?rid=5552896&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04331.x Conclusion:  Although exogenous hormones use was related to a more favourable fat distribution in women, smoking was associated with greater abdominal fat accumulation.© 2011 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5552896 Sat, 31 Dec 2011 13:48:41 +0100 5552896 http://www.medworm.com/index.php?rid=5538878&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04321.x Conclusion:  Our findings do not support an association between low 25OHD levels and statin‐induced myalgia or CK‐elevation.© 2011 Blackwell Publishing Ltd (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5538878 Sun, 25 Dec 2011 11:18:08 +0100 5538878 http://www.medworm.com/index.php?rid=5516352&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04324.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5516352 Mon, 19 Dec 2011 13:24:07 +0100 5516352 http://www.medworm.com/index.php?rid=5496638&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04318.x SummaryTwins are an important resource for evaluating the relative contribution of genetic and environmental factors in determining a phenotype. During the last decades a number of twin studies have investigated the aetiology of several phenotypes related to thyroid autoimmunity. Taken together, these studies have provided valid and unbiased information regarding the influence of genetic and environmental factors in the aetiology of autoimmune thyroid disease (AITD). The comparison of concordance rates between monozygotic and dizygotic twins provides irrefutable evidence of a genetic component, and biometric twin modelling shows that approximately 75% of the total phenotypic variance in AITD is due to genetic effects. On the other hand, the lack of complete concordance in monozygotic twin ... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5496638 Tue, 13 Dec 2011 17:18:06 +0100 5496638 http://www.medworm.com/index.php?rid=5480752&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04153.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480752 Wed, 07 Dec 2011 22:06:56 +0100 5480752 http://www.medworm.com/index.php?rid=5480751&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04183.x Conclusions  Our data demonstrate that the VEGF‐D serum levels are reduced in patients with metastases of differentiated thyroid cancer, regardless of the degree of metastatic spread. It is possible that some other molecule produced by the tumoral tissue could affect the VEGF‐D physiologically produced of from different tissues, thus conducting to a decrease in the VEGF‐D found in blood of patients with evidence of metastatic differentiated thyroid cancer. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480751 Wed, 07 Dec 2011 22:06:53 +0100 5480751 http://www.medworm.com/index.php?rid=5480750&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04185.x Conclusion  Single LH determination 90 min after GnRHa administration using a cut‐off level of 2·5 mIU/ml reflects pubertal suppression with a high sensitivity and specificity. However, this test may fail to show pubertal suppression in some cases. Those patients who appear to be inadequately suppressed should be reassessed using standard iv GnRH stimulation test for optimal dose adjustment. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480750 Wed, 07 Dec 2011 22:06:48 +0100 5480750 http://www.medworm.com/index.php?rid=5480749&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04171.x Conclusion  Visfatin may be a candidate to play a role in the pathogenesis of endothelial dysfunction in PCOS, independently of additional risk factors. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480749 Wed, 07 Dec 2011 22:06:46 +0100 5480749 http://www.medworm.com/index.php?rid=5480748&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04155.x Conclusions  In conclusion, we found that fat mass, insulin and IGF‐1 levels are important negative determinants of SHBG levels in young healthy men. The association with fat mass could be mediated by the effects of adiponectin and/or leptin on SHBG synthesis. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480748 Wed, 07 Dec 2011 22:06:44 +0100 5480748 http://www.medworm.com/index.php?rid=5480747&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04172.x Conclusions  Substantial differences in the outcome of childhood CP with different tumour growth patterns and locations were found, which suggested that diverse therapeutic considerations, especially endocrinological substitution, might be emphasized. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480747 Wed, 07 Dec 2011 22:06:43 +0100 5480747 http://www.medworm.com/index.php?rid=5480746&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04163.x Conclusions  Densely granulated adenomas were highly responsive to somatostatin analogues in contrast to SG adenomas. The transitional group behaved clinically more like DG adenomas. However, based on E‐cadherin, a marker of dedifferentiation, the transitional group seemed to be a true intermediate. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480746 Wed, 07 Dec 2011 22:06:41 +0100 5480746 http://www.medworm.com/index.php?rid=5480745&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04146.x Conclusion  Substitution with LB03002 showed statistically significant reduction in FM, which reduces leptin levels and increases ghrelin levels but does not seem to influence glucose and lipid metabolism. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480745 Wed, 07 Dec 2011 22:06:39 +0100 5480745 http://www.medworm.com/index.php?rid=5480744&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04161.x Conclusion  PWS patients display heterogeneity of hypogonadism: (i) hypogonadotropic hypogonadism of central origin for LH and/or FSH; (ii) early primary testicular dysfunction (Sertoli cells damage); and (iii) a combined hypogonadism (testicular origin for FSH‐inhibin B axis and central origin for LH‐T axis). (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480744 Wed, 07 Dec 2011 22:06:36 +0100 5480744 http://www.medworm.com/index.php?rid=5480743&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04141.x Conclusions  This study identified that SC‐preadipocyte differentiation is associated with metabolic syndrome independent of obesity, whereas OM‐preadipocyte differentiation is not. These findings suggest that, in the setting of obesity, an enhanced adipogenic capacity of SC depots could be protective for metabolic syndrome. Our data underscores an interaction between adipose tissue homoeostasis and metabolic disorder. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480743 Wed, 07 Dec 2011 22:06:33 +0100 5480743 http://www.medworm.com/index.php?rid=5480742&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04140.x Conclusion  Retinol‐binding protein 4 levels behave differently in EAT and SAT with respect to CAD. However, both adipose tissues have lower GLUT4 levels in patients with CAD. These findings suggest a differential regulation of RBP4 production in EAT and SAT that may be influenced by local factors. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480742 Wed, 07 Dec 2011 22:06:31 +0100 5480742 http://www.medworm.com/index.php?rid=5480741&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04184.x Conclusions  We report the first large germline deletion of the HRPT2 gene, which was not detectable by conventional PCR‐based sequencing methods. This finding emphasizes that qPCR should be implemented in HRPT2 molecular analysis, which may improve genetic assessment and clinical management of patients with FIHP and HPT‐JT. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480741 Wed, 07 Dec 2011 22:06:26 +0100 5480741 http://www.medworm.com/index.php?rid=5480740&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04177.x Conclusions  Patients with PA should have CT scanning and AVS. Aldo/Cort A:U >2·0 is the most accurate of previously published ratios in predicting unilateral disease. When patients were carefully selected for surgery, 97% had cure or improvement in blood pressure control. Further confirmatory work is required on a novel ratio which was even more predictive in our series. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480740 Wed, 07 Dec 2011 22:06:25 +0100 5480740 http://www.medworm.com/index.php?rid=5480739&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04103.x This article provides answers to the important daily clinical questions, such as correct dose finding, dose adaptation in special situations, e g, pregnancy, improvement of quality of life and measures for protection from adrenal crisis. Other important aspects discussed are side effects of glucocortiocid replacement therapy and interactions with other drugs. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480739 Wed, 07 Dec 2011 22:06:23 +0100 5480739 http://www.medworm.com/index.php?rid=5480738&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04176.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480738 Wed, 07 Dec 2011 22:06:21 +0100 5480738 http://www.medworm.com/index.php?rid=5480737&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04253.x SummarySubclinical Cushing’s syndrome is an ill‐defined endocrine disorder that may be observed in patients bearing an incidentally found adrenal adenoma. The concept of subclinical Cushing’s syndrome stands on the presence of ACTH‐independent cortisol secretion by an adrenal adenoma, that is not fully restrained by pituitary feed‐back. A hypercortisolemic state of usually minimal intensity may ensue and eventually cause harm to the patients in terms of metabolic and vascular diseases, and bone fractures. However, the natural history of subclinical Cushing’s syndrome remains largely unknown. The present review illustrates the currently used methods to ascertain the presence of subclinical Cushing’s syndrome and the surrounding controversy. The management of subclinical Cushin... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480737 Wed, 07 Dec 2011 22:06:19 +0100 5480737 http://www.medworm.com/index.php?rid=5480736&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04234.x SummaryProteins secreted from adipocytes – so‐called adipokines – influence metabolic and vascular function. Recent data suggest that various adipokines are dysregulated in gestational diabetes mellitus (GDM) and pre‐eclampsia (PE) and might be of pathophysiological and prognostic significance in these complications of pregnancy. This review gives an overview on the regulation and pathophysiology of leptin and adiponectin in GDM and PE. Furthermore, data on novel adipokines including resistin, visfatin, retinol‐binding protein 4 and vaspin are summarized. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480736 Wed, 07 Dec 2011 22:06:17 +0100 5480736 http://www.medworm.com/index.php?rid=5480735&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04281.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480735 Wed, 07 Dec 2011 22:06:16 +0100 5480735 http://www.medworm.com/index.php?rid=5480730&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04298.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480730 Wed, 07 Dec 2011 22:06:07 +0100 5480730 http://www.medworm.com/index.php?rid=5480732&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04308.x Conclusions:  The results of this study demonstrate an inverse association between birth weight and blood pressure and serum aldosterone and cortisol levels. This association is independent of BMI and Tanner, suggesting foetal programming of the hypothalamic‐ pituitary‐ adrenal axis. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480732 Tue, 06 Dec 2011 05:00:00 +0100 5480732 http://www.medworm.com/index.php?rid=5480731&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04309.x Conclusions:  Subjects with CAH have evidence of vascular dysfunction by adolescence. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480731 Tue, 06 Dec 2011 05:00:00 +0100 5480731 http://www.medworm.com/index.php?rid=5480733&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04307.x Conclusions:   EndemicGoitre in school children persisted nationwide, despite more than two decades of USI program. Thyroid autoimmunity only partially explainsthe increase in goitre prevalence. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480733 Mon, 05 Dec 2011 05:00:00 +0100 5480733 http://www.medworm.com/index.php?rid=5480734&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04306.x Conclusions:  An oral dose of DHEA‐S is useful for weight loss. In obese postmenopausal women the hormone significantly improves plasma biochemical levels and anthropometric characteristics, leading to a better metabolic profile, which highlights the usefulness of this therapy against Metabolic‐Syndrome in this group of women. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5480734 Fri, 02 Dec 2011 05:00:00 +0100 5480734 http://www.medworm.com/index.php?rid=5446781&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04304.x Conclusions:  GHIS in this patient is due to a heterozygous nonsense mutation in GHR. Our study is the first to demonstrate that nonsense‐mediated decay is involved in the phenotypic variability of GHIS caused by GHR mutations. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5446781 Sat, 26 Nov 2011 06:36:06 +0100 5446781 http://www.medworm.com/index.php?rid=5428166&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04254.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428166 Sun, 20 Nov 2011 10:55:16 +0100 5428166 http://www.medworm.com/index.php?rid=5428165&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04091.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428165 Sun, 20 Nov 2011 10:55:13 +0100 5428165 http://www.medworm.com/index.php?rid=5428164&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04120.x Conclusions  The mode of dialyzer modulates the blood levels of myostatin. Higher myostatin is associated with lower muscle function. The use of myostatin assay in various clinical settings merits further investigation. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428164 Sun, 20 Nov 2011 10:55:11 +0100 5428164 http://www.medworm.com/index.php?rid=5428163&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04157.x Conclusions  One week of a strict LID is enough to decrease the level of urine iodine excretion in preparation for RAIT even in high iodine intake areas. These results provide essential data for future outcome studies regarding LID preparation for RAIT. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428163 Sun, 20 Nov 2011 10:55:09 +0100 5428163 http://www.medworm.com/index.php?rid=5428162&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04154.x Conclusion  The BRAFV600E mutation is significantly associated with malignant US features, such as solid composition, marked hypoechogenicity, irregular margin, taller‐than‐wide shape and the presence of microcalcifications. The application of BRAFV600E mutation analysis in US‐guided FNAB can improve the diagnostic accuracy of thyroid nodules. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428162 Sun, 20 Nov 2011 10:55:08 +0100 5428162 http://www.medworm.com/index.php?rid=5428161&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04152.x Conclusions  These results indicate that once‐daily application of the testosterone topical solution 2% to the axillae is a safe and effective treatment for androgen replacement in hypogonadal men. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428161 Sun, 20 Nov 2011 10:55:06 +0100 5428161 http://www.medworm.com/index.php?rid=5428160&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04127.x Conclusion  These results suggest that elevated serum isoflavones may be associated with the risk of CPP in Korean girls. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428160 Sun, 20 Nov 2011 10:55:04 +0100 5428160 http://www.medworm.com/index.php?rid=5428159&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04109.x Conclusions  Corticotroph tumour progression was associated with reduced expression of the epithelial marker E‐cadherin. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428159 Sun, 20 Nov 2011 10:54:59 +0100 5428159 http://www.medworm.com/index.php?rid=5428158&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04128.x Conclusion  The rising incidence of CH in Massachusetts is confined to mild and delayed cases. Our findings suggest that this rise is attributable to enhanced detection rather than an absolute increase in numbers. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428158 Sun, 20 Nov 2011 10:54:57 +0100 5428158 http://www.medworm.com/index.php?rid=5428157&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04158.x Conclusions  I852M sequence variations represent genuine RET mutations, falling into ATA class A of weakly activating RET germline mutations. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428157 Sun, 20 Nov 2011 10:54:56 +0100 5428157 http://www.medworm.com/index.php?rid=5428156&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04134.x Conclusions  Gene copy number analysis by MLPA should be considered in patients with negative conventional mutation screening. Although large MEN1 deletion causes MEN1, disruption of imprinted CDKN1C/p57KIP2 and IGF‐2 gene expression may contribute to tumour progression and aggressive phenotype. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428156 Sun, 20 Nov 2011 10:54:54 +0100 5428156 http://www.medworm.com/index.php?rid=5428155&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04132.x Conclusions  The data, with correlation between BMI and fat thickness at different injection sites in relation to gender, provide guidance in selecting an adequate pen needle length for deep and safe subcutaneous self‐injection. WHR was a much weaker predictor when compared to BMI. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428155 Sun, 20 Nov 2011 10:54:52 +0100 5428155 http://www.medworm.com/index.php?rid=5428154&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04129.x Conclusions  Thus, HbA1c level is associated with subclinical atherosclerosis in carotid arteries in a Chinese population. The relationship is linear without an inflection point. However, HbA1c criterion is not a useful marker for the identification of subclinical atherosclerosis. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428154 Sun, 20 Nov 2011 10:54:51 +0100 5428154 http://www.medworm.com/index.php?rid=5428153&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04121.x Conclusions  IAT postpancreatectomy offers some patients a chance for insulin independence. Better data reporting are essential to establish the risks and benefits of IAT after pancreatic surgery. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428153 Sun, 20 Nov 2011 10:54:49 +0100 5428153 http://www.medworm.com/index.php?rid=5428152&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04119.x Conclusions  Serum CXCL5 is an important determinant of carotid artery IMT in patients with type 2 diabetes. The correlation is independent of inflammation and glucose control. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428152 Sun, 20 Nov 2011 10:54:47 +0100 5428152 http://www.medworm.com/index.php?rid=5428151&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04142.x Conclusion  This series increases the limited knowledge of mutations and phenotypes of this rare disorder. Mutation analysis of the CaSR gene facilitates patient and family management. Low dosages of calcitriol resulted in less frequent renal calcifications. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428151 Sun, 20 Nov 2011 10:54:46 +0100 5428151 http://www.medworm.com/index.php?rid=5428150&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04151.x Conclusion  In this unselected population of patients with classical 21OHD, we found high frequencies of adrenal tumours, particularly myelolipomas, and of hyperplasia and hypoplasia, and TART in SW. It is important that physicians are aware that benign adrenal and testicular tumours occur frequently in 21OHD. Furthermore, these findings may reflect inappropriate glucocorticoid therapy, making a case for the advancement of novel physiological treatment modalities. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428150 Sun, 20 Nov 2011 10:54:44 +0100 5428150 http://www.medworm.com/index.php?rid=5428149&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04143.x Conclusions  These data suggest sCgA as a reliable marker of SAM activation. Furthermore, the relationship between sCgA and exercise intensity highlights the potential use of this noninvasive parameter in monitoring the adrenergic response during intense physical stress. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428149 Sun, 20 Nov 2011 10:54:42 +0100 5428149 http://www.medworm.com/index.php?rid=5428148&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04092.x SummaryHypomagnesaemia is relatively common, with an estimated prevalence in the general population ranging from 2·5% to 15%. It may result from inadequate magnesium intake, increased gastrointestinal or renal loss or redistribution from extracellular to intracellular space. Drug‐induced hypomagnesaemia, particularly related to proton pump inhibitor (PPI) therapy, is being increasingly recognized. Most patients with hypomagnesaemia are asymptomatic; symptomatic magnesium depletion is often associated with multiple other biochemical abnormalities, including hypokalaemia, hypocalcaemia and metabolic acidosis. Manifestations of symptomatic hypomagnesaemia most often involve neuromuscular, cardiovascular and metabolic features. Patients with symptomatic hypomagnesaemia should be treated wit... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428148 Sun, 20 Nov 2011 10:54:41 +0100 5428148 http://www.medworm.com/index.php?rid=5428147&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04245.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428147 Sun, 20 Nov 2011 10:54:39 +0100 5428147 http://www.medworm.com/index.php?rid=5428146&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04225.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428146 Sun, 20 Nov 2011 10:54:37 +0100 5428146 http://www.medworm.com/index.php?rid=5428145&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04201.x SummaryPrimary hyperparathyroidism (PHPT) is a common incidental finding on routine biochemical testing, affecting around 1% of the population. The majority of individuals will be asymptomatic at diagnosis, with no evidence of end organ damage, and unless individuals aged <50 years at diagnosis, they are often considered to have ‘mild’ PHPT, as they do not meet published criteria for parathyroidectomy (PTX). However, there is increasing evidence that ‘mild’ PHPT is associated with adverse health outcomes. Long‐term observational studies describing the natural history of ‘mild’ PHPT suggest that even though biochemistry may be relatively stable in the majority, bone mineral density (BMD) does decline after approximately 10 years of observation, whereas significant impro... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428145 Sun, 20 Nov 2011 10:54:36 +0100 5428145 http://www.medworm.com/index.php?rid=5428144&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04148.x This article will review the literature underpinning the hypothesis that spironolactone may have a role in maintaining muscle function in older people. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428144 Sun, 20 Nov 2011 10:54:34 +0100 5428144 http://www.medworm.com/index.php?rid=5428129&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04284.x Conclusions:  Monocyte/macrophage activation, as reflected by sCD163 levels, is strongly associated with HOMA‐IR in normal‐weight and obese subjects after controlling for known mediators of insulin resistance. Moreover, sCD163 adds to standard risk markers for predicting insulin resistance. These data suggest that monocyte/macrophage activation may be an important determinant of insulin resistance in obesity. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428129 Sun, 20 Nov 2011 10:54:05 +0100 5428129 http://www.medworm.com/index.php?rid=5428130&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04277.x Conclusion: Use of oral contraceptive pills containing ethinylestradiol should be avoided in women receiving treatment with growth hormone. Alternative options include oral or transdermal HRT preparations for those that require oestrogen replacement or a progesterone based regimen for contraceptive purposes. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428130 Sat, 19 Nov 2011 05:00:00 +0100 5428130 http://www.medworm.com/index.php?rid=5428131&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04294.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428131 Fri, 18 Nov 2011 05:00:00 +0100 5428131 http://www.medworm.com/index.php?rid=5428136&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04288.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428136 Fri, 11 Nov 2011 05:00:00 +0100 5428136 http://www.medworm.com/index.php?rid=5428135&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04289.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428135 Fri, 11 Nov 2011 05:00:00 +0100 5428135 http://www.medworm.com/index.php?rid=5428134&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04290.x Conclusions:  High‐normal FT4 level is an independent predictor of frailty among ageing men. This suggests that even within the euthyroid range, circulating thyroxine may contribute to reduced physical capability. Further studies are needed to clarify the utility of thyroid function testing and the feasibility of preventing or reversing frailty in older men. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428134 Fri, 11 Nov 2011 05:00:00 +0100 5428134 http://www.medworm.com/index.php?rid=5428133&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04291.x Conclusions:  This study demonstrates that in NAFLD patients the GHBP levels are increased and that the GH/IGF‐I axis is significantly altered probably leading to reduced IGF‐I bioavailability at tissue level. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428133 Fri, 11 Nov 2011 05:00:00 +0100 5428133 http://www.medworm.com/index.php?rid=5428132&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04292.x Conclusion:  Evaluation of cold thyroid nodules by MIBI‐scintigraphy aids therapeutic decisions: MIBI‐negative findings support non‐surgical management in about two thirds of patients, while MIBI‐positive findings have an increased risk of malignancy supporting surgical therapy. However the positive predictive value was low, which requires further research. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428132 Fri, 11 Nov 2011 05:00:00 +0100 5428132 http://www.medworm.com/index.php?rid=5428143&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04285.x Conclusion:  For a given specificity, primary hyperparathyroidism diagnostic PTH thresholds were lower and sensitivities higher using ROC curves, derived from 25(OH)D replete versus deplete controls. The 25(OH)D status does not affect the efficiency of primary hyperparathyroidism diagnosis, using bivariate PTH/calcium reference density ellipses. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428143 Tue, 08 Nov 2011 05:00:00 +0100 5428143 http://www.medworm.com/index.php?rid=5428142&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04286.x Conclusion:  In patients with acromegaly, T2 signal intensity at diagnosis correlates with histological features and predicts biochemical outcome of first line SA treatment. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428142 Tue, 08 Nov 2011 05:00:00 +0100 5428142 http://www.medworm.com/index.php?rid=5428141&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04287.x Conclusions:  These results suggest that aromatase is a novel endocrine factor predictive of CVD mortality among postmenopausal women. If confirmed, additional studies are needed to determine whether extremes of aromatase reflect genetic influences or underlying disease processes. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428141 Tue, 08 Nov 2011 05:00:00 +0100 5428141 http://www.medworm.com/index.php?rid=5428140&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04256.x Conclusions:  We have identified a novel GCMB mutation that may explain AD‐HP in our family. However, the exact mechanism by which this heterozygous mutation leads to the disease in the described family remains to be elucidated. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428140 Tue, 08 Nov 2011 05:00:00 +0100 5428140 http://www.medworm.com/index.php?rid=5428139&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04280.x Conclusion:  The Tuebingen CD‐25 is a feasible instrument to assess HRQoL in CD in a clinical and investigative setting and provides normative data for all age groups and genders. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428139 Tue, 08 Nov 2011 05:00:00 +0100 5428139 http://www.medworm.com/index.php?rid=5428138&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04276.x Conclusion:  Moderately elevated ACTH is a more useful early indicator of impending AD than 21OH‐AA, PRA, or peak cortisol, in the 2 months to 2 years preceding the onset of AD. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428138 Tue, 08 Nov 2011 05:00:00 +0100 5428138 http://www.medworm.com/index.php?rid=5428137&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04282.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5428137 Tue, 08 Nov 2011 05:00:00 +0100 5428137 http://www.medworm.com/index.php?rid=5383402&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04283.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383402 Mon, 07 Nov 2011 05:00:00 +0100 5383402 http://www.medworm.com/index.php?rid=5383405&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04266.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383405 Wed, 02 Nov 2011 04:00:00 +0100 5383405 http://www.medworm.com/index.php?rid=5383404&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04278.x Conclusions:  Our study confirms that in the setting of I‐131 ablation therapy or diagnostic I‐131 scanning, a significant proportion of patients (20.2% and 8.3% respectively) have residual benign or malignant thyroid tissue on whole body scanning despite a negative stimulated serum Tg level. Whether such patients who would otherwise be missed as having residual thyroid tissue on serum Tg testing alone have a worse clinical outcome remains uncertain. Our findings do however suggest performing both stimulated serum Tg/TgAb levels and I‐131 scans for follow up of patients with higher risk thyroid cancer may be important. There may also be a slightly higher incidence of this phenomenon in patients prepared with rhTSH rather than by thyroxine withdrawal. (Source: Clinical Endocrinology... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383404 Wed, 02 Nov 2011 04:00:00 +0100 5383404 http://www.medworm.com/index.php?rid=5383403&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04279.x Conclusions:  Based on the findings outlined, MRI‐negative CD may be a surgically remediable syndrome, with a pathophysiological basis that primarily involves a pituitary cause of the hypercortisolaemia. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383403 Wed, 02 Nov 2011 04:00:00 +0100 5383403 http://www.medworm.com/index.php?rid=5383401&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04272.x Conclusion: The care of patients with DTC and distant metastases is like walking an endocrinological tightrope: non‐suppressed TSH levels, i.e. > 0.1 mU/l, are associated with an impaired prognosis. There is, however, no prognostic benefit from suppressing TSH to levels lower than 0.1 mU/l. On the contrary, an improvement in prognosis might be achieved by keeping FT3 levels as low as possible. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5383401 Tue, 01 Nov 2011 04:00:00 +0100 5383401 http://www.medworm.com/index.php?rid=5363550&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04271.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5363550 Tue, 01 Nov 2011 04:00:00 +0100 5363550 http://www.medworm.com/index.php?rid=5348150&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04270.x Conclusions:  Our data suggest that anterior hypopituitarism is rare in adult idiopathic diabetes insipidus. Routine screening of these patients for anterior hypopituitarism may not therefore be indicated. The significant prevalence of autoimmune disease in this cohort supports the hypothesis that idiopathic diabetes insipidus may have an autoimmune aetiology. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5348150 Wed, 26 Oct 2011 15:15:23 +0100 5348150 http://www.medworm.com/index.php?rid=5332768&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04257.x Conclusions:  Using Prolactin as a concurrent index of pituitary venous effluent helps us recognise whether pituitary venous blood has been accurately sampled. Normalising the IPS:peripheral ratios with Prolactin helps to improve the accuracy of the result and reduces the false negative rate. With regards to the usefulness / validity of this test in clinical practice; it is relevant, reproducible and is easily adaptable from the existing diagnostic sequence. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5332768 Fri, 21 Oct 2011 03:20:06 +0100 5332768 http://www.medworm.com/index.php?rid=5317259&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04263.x Conclusions:  The present study suggests that one allele mutation in the GHRHR gene has a greater impact on energy metabolism than on bone quality. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5317259 Sat, 15 Oct 2011 18:35:06 +0100 5317259 http://www.medworm.com/index.php?rid=5302098&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04251.x Conclusions:  Coeliac disease, elevated TSH and TPOAb at presentation and a progressive increase of TSH are predictive factors for thyroid failure in HT patients. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5302098 Mon, 10 Oct 2011 15:25:07 +0100 5302098 http://www.medworm.com/index.php?rid=5284246&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04081.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284246 Wed, 05 Oct 2011 14:51:02 +0100 5284246 http://www.medworm.com/index.php?rid=5284245&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04101.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284245 Wed, 05 Oct 2011 14:51:01 +0100 5284245 http://www.medworm.com/index.php?rid=5284244&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04077.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284244 Wed, 05 Oct 2011 14:50:59 +0100 5284244 http://www.medworm.com/index.php?rid=5284243&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04156.x Conclusions  This study identified underlying TSHR and TPO mutations in Korean patients with CH and revealed a possible relationship between imaging findings and mutation status. In addition, the low rate of mutation positivity suggests significant genetic heterogeneity of CH in the Korean population. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284243 Wed, 05 Oct 2011 14:50:57 +0100 5284243 http://www.medworm.com/index.php?rid=5284242&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04138.x Conclusions  In subjects with SCH at the early phase of TSH‐suppressive therapy, evidence of isolated longitudinal LV diastolic dysfunction was observed, despite a normal LV morphology. Further prospective studies to clarify the prognosis of picking‐up early diastolic dysfunction in asymptomatic patients are needed before serial measurements could be recommended. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284242 Wed, 05 Oct 2011 14:50:56 +0100 5284242 http://www.medworm.com/index.php?rid=5284241&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04126.x Conclusion  Our results suggest an increased risk of UI in patients with hyperthyroidism at the 3‐year follow‐up. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284241 Wed, 05 Oct 2011 14:50:54 +0100 5284241 http://www.medworm.com/index.php?rid=5284240&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04122.x Conclusions  In women with PCOS, the degree of anxiety, state and trait (STAI‐S, STAI‐T) appears to vary in a pattern similar to that of hyperandrogenemia and insulin resistance, independently of age and BMI. The pathophysiological mechanisms underlying the association of psychological morbidities with androgen excess and insulin resistance in PCOS remain to be elucidated. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284240 Wed, 05 Oct 2011 14:50:53 +0100 5284240 http://www.medworm.com/index.php?rid=5284239&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04113.x Conclusions  Metabolic syndrome was no more frequent in a representative sample of PCOS Iranian population than in healthy controls. However, the prevalence of IR in PCOS appears to be higher than in controls. It seems that the association between PCOS and MetS needs more consideration. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284239 Wed, 05 Oct 2011 14:50:51 +0100 5284239 http://www.medworm.com/index.php?rid=5284238&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04108.x Conclusions  In acromegalic patients, there is no difference in GH nadirs and test interpretation after the ingestion of 100 g or 75 g glucose. The OGTT75 is highly reproducible in men, but in women, it should be performed preferably in the early follicular phase. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284238 Wed, 05 Oct 2011 14:50:49 +0100 5284238 http://www.medworm.com/index.php?rid=5284237&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04106.x Conclusion  Primary surgical treatment seems to be slightly more effective than Oct‐LAR in terms of biochemical response and IGF‐1 control, besides tumour volume reduction, in patients with acromegaly with noninvasive tumours. Oct‐LAR is associated with more side effects such as cholelithiasis and glucose metabolism disorders and is more expensive. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284237 Wed, 05 Oct 2011 14:50:48 +0100 5284237 http://www.medworm.com/index.php?rid=5284236&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04098.x Conclusions  3T MRI appears to offer increased conspicuity and detection of GH‐ and ACTH‐secreting pituitary microadenomas. It is potentially clinically useful when 1·5T imaging is negative or equivocal. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284236 Wed, 05 Oct 2011 14:50:46 +0100 5284236 http://www.medworm.com/index.php?rid=5284235&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04096.x Conclusions  Our study indicates that the hCRH and DDAVP tests have similar diagnostic performance and present excellent agreement, without giving simultaneous misdiagnosis in any subject. Because of these characteristics, the use of both tests offers the physician a valuable tool for those cases of hypercortisolism which are difficult to interpret. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284235 Wed, 05 Oct 2011 14:50:44 +0100 5284235 http://www.medworm.com/index.php?rid=5284234&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04116.x Conclusion  Preterm children are shorter and lighter than controls throughout childhood, remaining below their genetic height potential. Preterm birth appears to alter the endocrine regulation of postnatal growth in childhood and adolescence, so growth is no longer associated with its normal endocrine regulators. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284234 Wed, 05 Oct 2011 14:50:43 +0100 5284234 http://www.medworm.com/index.php?rid=5284233&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04104.x Conclusions  According to our results, the exon 3‐deleted GHR explains the better growth response to GH only for the first and not for the second year. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284233 Wed, 05 Oct 2011 14:50:41 +0100 5284233 http://www.medworm.com/index.php?rid=5284232&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04111.x Conclusion LMNA 1908T/T and C/T genotypes emerged as independent genetic risk factors for generalized obesity in Asian north Indians. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284232 Wed, 05 Oct 2011 14:50:38 +0100 5284232 http://www.medworm.com/index.php?rid=5284231&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04102.x Conclusions  Mean age of diagnosis of diabetes among the Polish patients was typical for Wolfram syndrome; however, compound‐heterozygous patients were slightly older at diabetes onset. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284231 Wed, 05 Oct 2011 14:50:36 +0100 5284231 http://www.medworm.com/index.php?rid=5284230&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04094.x Conclusions  Previously reported improvements in treatment and control rates between 1998 and 2003 continued between 2003 and 2006, with the biggest increases among those with established CVD and diabetes. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284230 Wed, 05 Oct 2011 14:50:33 +0100 5284230 http://www.medworm.com/index.php?rid=5284229&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04110.x Conclusions  Vitamin D deficiency is common in the older population in the Netherlands, and subjects with serum 25 OHD below 50 nm have a higher risk of the metabolic syndrome. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284229 Wed, 05 Oct 2011 14:50:30 +0100 5284229 http://www.medworm.com/index.php?rid=5284228&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04130.x Conclusion  Patients in remission after pituitary surgery for CD showed a rapid decrease of adrenal responsiveness to exogenous ACTH stimulation. This phenomenon may be explained by ACTH‐receptor down‐regulation in the adrenal cortex after complete removal of the pituitary corticotroph adenoma. In our study, the postoperative low‐dose ACTH stimulation test had a sensitivity of 93% and a specificity of 87% in predicting immediate remission of CD after pituitary surgery. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284228 Wed, 05 Oct 2011 14:50:28 +0100 5284228 http://www.medworm.com/index.php?rid=5284227&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04125.x Conclusions  The results suggest that endogenous ACTH–adrenal drive can be approximated from overnight 8‐h sampling of paired ACTH and cortisol concentrations. This strategy may have merit in clinical research in childhood, pregnancy, anxiety states and frail elderly individuals, when ACTH injections are not desired. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284227 Wed, 05 Oct 2011 14:50:27 +0100 5284227 http://www.medworm.com/index.php?rid=5284226&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04050.x SummaryPrimary hyperparathyroidism (PHPT) is a common, often asymptomatic, endocrine disorder characterized by hypercalcaemia in the face of a nonsuppressed parathyroid hormone (PTH) level. For those with symptomatic disease or who meet surgical criteria, parathyroidectomy is the treatment of choice. However, those patients who do not meet surgical criteria or who cannot undergo or refuse surgery must be managed medically. Medical management of PHPT involves continual assessment to determine who will benefit from surgical intervention, replacement of vitamin D, treatment of parathyroid bone disease and management of hypercalcaemia and renal stone disease. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284226 Wed, 05 Oct 2011 14:50:25 +0100 5284226 http://www.medworm.com/index.php?rid=5284225&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04214.x SummaryMitotane [1‐(2‐chlorophenyl)‐1‐(4‐chlorophenyl)‐2,2‐dichloroethane, (o,p’‐DDD)] is the only drug approved for the treatment for adrenocortical carcinoma (ACC) and has also been used for various forms of glucocorticoid excess. Through still largely unknown mechanisms, mitotane inhibits adrenal steroid synthesis and adrenocortical cell proliferation. Mitotane increases hepatic metabolism of cortisol, and an increased replacement dose of glucocorticoids is standard of care during mitotane treatment. Recently, sunitinib, a multityrosine kinase inhibitor (TKI), has been found to be rapidly metabolized by CYP3A4 during mitotane treatment, indicating clinically relevant drug interactions with mitotane. We here summarize the current evidence concerning mitotane‐induced c... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284225 Wed, 05 Oct 2011 14:50:23 +0100 5284225 http://www.medworm.com/index.php?rid=5284224&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04147.x SummaryA poor vitamin D status, i.e. low serum levels of 25‐hydroxyvitamin D [25(OH)D], is common in the general population. This finding is of concern not only because of the classic vitamin D effects on musculoskeletal outcomes, but also because expression of the vitamin D receptor (VDR) and vitamin D metabolizing enzymes in the heart and blood vessels suggests a role of vitamin D in the cardiovascular system. VDR‐knockout mice suffer from cardiovascular disease (CVD), and various experimental studies suggest cardiovascular protection by vitamin D, including antiatherosclerotic, anti‐inflammatory and direct cardio‐protective actions, beneficial effects on classic cardiovascular risk factors as well as suppression of parathyroid hormone (PTH) levels. In epidemiological studies, lo... Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284224 Wed, 05 Oct 2011 14:50:22 +0100 5284224 http://www.medworm.com/index.php?rid=5284222&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04242.x Conclusion:  Short‐term medium‐dose prednisone treatment induces postprandial hyperglycaemia in T2DM and AR predominantly from midday to midnight due suppression of insulin secretion followed by decreased insulin action that dissipates overnight. Effective treatment of prednisone‐induced hyperglycaemia should target both rapid onset relative insulin deficiency and a less than 24‐hour total duration of effect. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284222 Wed, 05 Oct 2011 14:50:19 +0100 5284222 http://www.medworm.com/index.php?rid=5284223&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04247.x Conclusions:  The C4B*Q0 genotype may be associated with hyperreactivity of the HPA axis (manifested as an increased responsiveness to ACTH‐stimulation), probably through enhanced function of steroid 21‐hydroxylase. Since hyperreactivity of the HPA axis is known to be associated with an increased risk of cardiovascular disease, our present findings may explain the increased cardiovascular morbidity and mortality of C4B*Q0 carriers. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5284223 Mon, 03 Oct 2011 04:00:00 +0100 5284223 http://www.medworm.com/index.php?rid=5268611&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04244.x Conclusions:  Circulating lipid‐related intermediate metabolites can be closely associated with inflammation, oxidative stress, and arterial stiffness in early diabetes. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5268611 Fri, 30 Sep 2011 11:10:32 +0100 5268611 http://www.medworm.com/index.php?rid=5249668&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04211.x Conclusions:  These results suggest that increase of muscle blood flow after a meal is impaired at all stages of type‐2 diabetes. This defect influences glucose uptake, and is associated with impaired lipid metabolism in the postprandial state. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5249668 Sat, 24 Sep 2011 22:24:07 +0100 5249668 http://www.medworm.com/index.php?rid=5235159&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04216.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5235159 Tue, 20 Sep 2011 17:24:08 +0100 5235159 http://www.medworm.com/index.php?rid=5221681&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04071.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221681 Fri, 16 Sep 2011 01:01:17 +0100 5221681 http://www.medworm.com/index.php?rid=5221680&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04064.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221680 Fri, 16 Sep 2011 01:01:13 +0100 5221680 http://www.medworm.com/index.php?rid=5221679&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04063.x (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221679 Fri, 16 Sep 2011 01:01:12 +0100 5221679 http://www.medworm.com/index.php?rid=5221678&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04075.x Conclusions  Serum PRL concentrations are associated with inflammatory biomarkers including IL‐6 and WBC, but not hsCRP or fibrinogen. The suggested role of PRL in inflammation needs further investigation in future prospective studies. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221678 Fri, 16 Sep 2011 01:01:10 +0100 5221678 http://www.medworm.com/index.php?rid=5221677&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04115.x Conclusions  Pyrosequencing is an effective method for detecting the BRAFV600E mutation in FNAB samples. By allowing the optimal cut‐off value to be determined, pyrosequencing improves the diagnostic sensitivity while eliminating the possibility of FP results. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221677 Fri, 16 Sep 2011 01:01:08 +0100 5221677 http://www.medworm.com/index.php?rid=5221676&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04114.x Conclusion  This review indicates that thyroid cancer survivors generally have a similar or slightly worse HRQoL compared with the normative population; however, they report some specific medical problems after cancer treatment and follow‐up tests, which have a direct negative impact on their current HRQoL and could affect their long‐term HRQoL. Specific longitudinal survivorship studies are lacking. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221676 Fri, 16 Sep 2011 01:01:07 +0100 5221676 http://www.medworm.com/index.php?rid=5221675&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04112.x Conclusions  Our results point to the immunomodulatory effects of IFN‐α on different lymphocyte subpopulations and a possible role of Th1 response and Tregs in patients with HCV who developed IIT. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221675 Fri, 16 Sep 2011 01:01:05 +0100 5221675 http://www.medworm.com/index.php?rid=5221674&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04107.x Conclusions  The presence of focal uptake with high SUV max and euthyroidism correlate with high likelihood of malignancy. Performing a neck US would have to be recommended in all patients with euthyroidism and an incidental FDG‐PET/CT focal thyroid uptake. We do not suggest to use FDG‐PET/CT as a screening tool for thyroid cancer in the general population, because of both its high cost and low incidence of thyroid incidentaloma at FDG‐PET/CT. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221674 Fri, 16 Sep 2011 01:01:03 +0100 5221674 http://www.medworm.com/index.php?rid=5221673&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04093.x Conclusions  Treatment with metformin is indicated in all hyperinsulinaemic overweight patients with PCOS, especially in those with NAFLD. These data appear even more interesting considering their increased risk to develop metabolic and hepatic complications. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221673 Fri, 16 Sep 2011 01:01:01 +0100 5221673 http://www.medworm.com/index.php?rid=5221672&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04084.x Conclusion  Plasma FGF21 follows a circadian rhythm during a 72‐h fast in healthy female subjects. The circadian regulation has a stronger impact on plasma FGF21 than the fasting status over 72‐h period. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221672 Fri, 16 Sep 2011 01:00:59 +0100 5221672 http://www.medworm.com/index.php?rid=5221671&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04074.x Conclusions  The lower dose of hydrocortisone (10 mg/5 mg) produces a more physiological cortisol profile, without compromising QoL, compared to higher doses still used in clinical practice. This may have important implications in these patients, known to have excess cardiovascular mortality. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221671 Fri, 16 Sep 2011 01:00:57 +0100 5221671 http://www.medworm.com/index.php?rid=5221670&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04068.x Conclusions  Patients with classical pituitary apoplexy may show recurrent pituitary tumour growth and therefore these patients need continued post‐operative surveillance if they have not had post‐operative radiotherapy. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221670 Fri, 16 Sep 2011 01:00:56 +0100 5221670 http://www.medworm.com/index.php?rid=5221669&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04067.x Conclusion  The aortic root diameter was higher, and the prevalence of aortic ectasia was more common in acromegalic patients than in controls. In addition, only acromegalic disease was associated with aortic ectasia, suggesting the direct effects of GH and insulin‐like growth factor‐I excess on the cardiovascular system. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221669 Fri, 16 Sep 2011 01:00:54 +0100 5221669 http://www.medworm.com/index.php?rid=5221668&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04117.x Conclusions  Hypoglycaemia is not uncommon during the low‐dose GST. Young children, especially those <8 years old, are particularly at risk. BG monitoring should be considered essential from a safety perspective. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221668 Fri, 16 Sep 2011 01:00:52 +0100 5221668 http://www.medworm.com/index.php?rid=5221667&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04088.x Conclusion  GH is strongly associated with pubertal bone metabolism, independent of systemic IGF‐1 in girls and boys. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221667 Fri, 16 Sep 2011 01:00:50 +0100 5221667 http://www.medworm.com/index.php?rid=5221666&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04085.x Conclusions  More than 10% of normal‐weight subjects were classed as MONW in this cohort. Identification of these subjects based on lipid profiles could aid in the early detection of a high risk group of developing cardiometabolic diseases. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221666 Fri, 16 Sep 2011 01:00:48 +0100 5221666 http://www.medworm.com/index.php?rid=5221665&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04079.x Conclusions  AGER 82S allele showed a protective effect on CAD severity in the presence of T2DM in Chinese Han population. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221665 Fri, 16 Sep 2011 01:00:46 +0100 5221665 http://www.medworm.com/index.php?rid=5221664&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04078.x Conclusions  A 3‐month combined exercise programme decreases the FGF21 levels as well as arterial stiffness in obese Korean women. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221664 Fri, 16 Sep 2011 01:00:44 +0100 5221664 http://www.medworm.com/index.php?rid=5221663&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04073.x Conclusion  Restoring serum DHEAS levels in older adults to young adult levels for 1 year does not appear to reduce central adiposity or improve insulin action. The benefit of DHEA on decreasing serum triglycerides must be weighed against the HDL‐lowering effect. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221663 Fri, 16 Sep 2011 01:00:42 +0100 5221663 http://www.medworm.com/index.php?rid=5221662&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04070.x Conclusions  IGT and NDD are positively associated with serum fetuin‐A concentrations in subjects without NAFLD independent of cardiometabolic risk factors. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221662 Fri, 16 Sep 2011 01:00:40 +0100 5221662 http://www.medworm.com/index.php?rid=5221661&cid=s_33008_15_f&fid=33008&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2265.2011.04124.x Conclusion  CS is associated with both high mortality and a high prevalence of co‐morbidities, even when biochemical cure rates are between 80% and 90%. (Source: Clinical Endocrinology) Clinical Endocrinology journals http://www.medworm.com/rss/comments.php?id=5221661 Fri, 16 Sep 2011 01:00:36 +0100 5221661