MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Evidence' source. Thu, 18 Mar 2010 14:39:56 +0100 http://www.medworm.com/index.php?rid=3367946&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Feyd%2F0704%2F0704.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Empirical treatment with topical antibiotics in people with suspected bacterial conjunctivitis One RCT with weak methods added comparing moxifloxacin versus combination trimethoprim/polymyxin. The RCT found that moxifloxacin increased clinical and microbiological cure rates compared with trimethoprim/polymyxin, which ran contrary to findings of multiple other RCTs that found equivalent effectiveness for these outcomes when different antibiotics were compared with each other. Categorisation unchanged (Likely to be beneficial). Antibiotics (topical) in people with culture-positive non-gonococcal bacterial conjunctivitis Five RCTs added. The first three RCTs compared top... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3367946 Mon, 15 Mar 2010 23:00:00 +0100 3367946 http://www.medworm.com/index.php?rid=3308874&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0804%2F0804.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Tibolone Two RCTs added comparing tibolone versus placebo. The first RCT found that tibolone (both 1.25 and 2.5 mg) reduced the frequency and severity of hot flushes at 12 weeks. The second RCT evaluated the risk of breast cancer recurrence with tibolone, and was stopped early after finding that tibolone significantly increased the rate of breast cancer at a median follow-up of 3.5 years.Categorisation changed (from Beneficial to Trade-off between benefits and harms). New evidence; conclusion confirmed for: Oestrogens alone Three RCTs evaluating vasomotor symptoms added. All three RCTs found that oestrogen reduced hot-flush frequency and severity compared with placeb... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3308874 Thu, 25 Feb 2010 23:00:00 +0100 3308874 http://www.medworm.com/index.php?rid=3308873&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0204%2F0204.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Angiotensin II receptor blockers for diastolic heart failure One RCT added comparing irbesartan versus placebo found no significant difference between irbesartan and placebo in all-cause mortality or in hospital admission for cardiovascular causes at a mean follow-up of 49.5 months. Evidence for effect of irbesartan on hospital admission for cardiovascular disease differs from evidence previously reported for candesartan for this outcome. Effects of angiotensin II receptor blockers as a class in treatment of diastolic heart failure is unclear. Categorisation changed from Likely to be beneficial to Unknown effectiveness. New evidence; conclusion confirmed for: Multidisciplinary intervent... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3308873 Thu, 25 Feb 2010 23:00:00 +0100 3308873 http://www.medworm.com/index.php?rid=3285691&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0214%2F0214.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Potassium supplementation One systematic review added found no significant difference at 8 to 16 weeks between potassium supplementation and placebo in improvement in systolic and diastolic blood pressure, although the difference between groups for both outcomes was large.The authors of the review also commented that follow-up of some of the RCTs included in the meta-analysis may have been too short to draw conclusions on the effectiveness of potassium supplementation. The findings and conclusion reached by the review differ from systematic review evidence previously presented. One review and one RCT added assessing the effects of combined mineral supplementation on blood pressure found no significant difference between place... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3285691 Thu, 18 Feb 2010 23:00:00 +0100 3285691 http://www.medworm.com/index.php?rid=3271939&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fend%2F0604%2F0604.jsp%3Frss%3Dtrue New option(s) added for: Diethylpropion New option for which we found one systematic review. The review found less weight loss with diethylpropion compared with phentermine. Data were from one small RCT and effects of diethylpropion in weight loss are unclear. Categorised as Unknown effectiveness. Mazindol New option for which we found no evidence. Categorised as Unknown effectiveness. Bariatric surgery New option for which we found one systematic review. The review identified two RCTs and three cohort studies assessing the effects of various bariatric surgical techniques (gastric banding, gastric bypass, vertical banded gastroplasty, biliopancreatic diversion, and sleeve gastrectomy) in people with morbid obesity. All studies ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3271939 Thu, 11 Feb 2010 23:00:00 +0100 3271939 http://www.medworm.com/index.php?rid=3260751&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1212%2F1212.jsp%3Frss%3Dtrue New option(s) added for: Zolmitriptan (intranasal) to abort cluster headache New option for which we found two RCTs. Both RCTs found that intranasal zolmitriptan improved headache relief and pain at 30 minutes compared with placebo. Categorised as Beneficial. New evidence; conclusion confirmed for: High-dose and high-flow-rate oxygen One systematic review added identified no new evidence assessing the effects of high-dose and high-flow-rate oxygen to abort cluster headache. Categorisation unchanged (Likely to be beneficial by consensus). Hyperbaric oxygen One systematic review added identified no new evidence assessing the effects of hyperbaric oxygen to abort cluster headache. Categorisation uncha... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3260751 Tue, 09 Feb 2010 23:00:00 +0100 3260751 http://www.medworm.com/index.php?rid=3260750&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0306%2F0306.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Prophylactic antibiotics One systematic review (search date 2006) and two subsequent RCTs added, which compared antibiotic prophylaxis versus no treatment. The systematic review included children with primary vesicoureteric reflux (VUR), and identified one RCT; the first subsequent RCT included children with febrile UTI and primary VUR; and the second subsequent RCT included children with a febrile UTI, with or without VUR. The systematic review and subsequent RCTs found no significant differences in the recurrence of febrile UTI and parenchymal defects between antibiotic prophylaxis and no treatment. One further RCT added, which compared trimethoprim–sulfamethoxazole versus nitrofurantoin in children with a previ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3260750 Tue, 09 Feb 2010 23:00:00 +0100 3260750 http://www.medworm.com/index.php?rid=3256726&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0309%2F0309.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Simethicone versus placebo: One systematic review added comparing the effects of simethicone versus placebo on duration of crying or presence of colic in infants. This review superseded two earlier reviews, but added no further evidence. Categorisation unchanged (Unknown effectiveness) as there remains insufficient good-quality evidence to assess simethicone. Spinal manipulation versus simethicone: One systematic review added, which included the same RCT as the previously included review, therefore no new data was added. Categorisation unchanged (Unknown effectiveness). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3256726 Fri, 05 Feb 2010 23:00:00 +0100 3256726 http://www.medworm.com/index.php?rid=3233422&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1005%2F1005.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Fluoxetine to treat PTSD Two RCTs added found no significant difference between fluoxetine and placebo in PTSD symptoms at the end of treatment (8–12 weeks). One of the RCTs also found no significant difference between fluoxetine and placebo in the proportion of people no longer meeting diagnostic criteria for PTSD at the end of treatment. One RCT compared fluoxetine versus eye movement desensitisation and reprocessing (EMDR). It found no significant difference between treatments in PTSD symptoms at the end of treatment. However, EMDR was found to be more effective at sustaining improvement in symptoms at 6 months compared with fluoxetine. Evidence added at update suggests effects of fluoxetine in treating PTSD ar... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3233422 Wed, 03 Feb 2010 14:43:06 +0100 3233422 http://www.medworm.com/index.php?rid=3233421&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Find%2F0921%2F0921.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Interferon plus ribavirin in treatment-naïve people One systematic review added found that a significantly smaller proportion of people achieved SVR with interferon plus ribavirin compared with peginterferon plus ribavirin. Although evidence suggests that interferon plus ribavirin is less effective than peginterferon plus ribavirin, there is evidence that combination interferon treatment is more effective than interferon monotherapy. Categorisation unchanged (Beneficial). Peginterferon plus ribavirin in treatment-naïve people One RCT added found that peginterferon plus ribavirin (dose based on patient's weight) increased the proportion of people achieving sustained virological response (SVR) compared with... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3233421 Wed, 03 Feb 2010 14:43:03 +0100 3233421 http://www.medworm.com/index.php?rid=3233424&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Frdc%2F1501%2F1501.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Education about acute asthma One systematic review (search date 2006) added comparing education versus usual care in adults who had attended an emergency department for asthma exacerbation. It found that education reduced hospital admissions compared with usual care, but it found no significant difference in subsequent presentations to emergency departments, primary care physician urgent visits, primary care physician call outs, quality of life, physical limitations caused by asthma, or lung function, between education and control. Evidence added at update does not support evidence previously reported on effects of education about asthma. Considering evidence added at update, categorisation changed from "Beneficial" to "Unkno... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3233424 Thu, 21 Jan 2010 23:00:00 +0100 3233424 http://www.medworm.com/index.php?rid=3161333&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1404%2F1404.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Magnesium sulphate: Two systematic reviews added to the comments section. The first review reported that the percentage of women with a successful delay of delivery by 48 hours was 53% with control/placebo and 89% with magnesium sulphate. The percentage of women with successful delay of labour until 37 weeks was 36% with control/placebo and 42% with magnesium sulphate. Neonatal mortality occurred in 2% with placebo and 1% with magnesium sulphate. Overall rates of adverse effects were 1% with placebo and 3% with magnesium sulphate. However, no direct comparisons were made in this review. The second review reported that magnesium sulphate given before preterm delivery for neuroprotection has demonstrated a reduction in... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3161333 Mon, 11 Jan 2010 23:00:00 +0100 3161333 http://www.medworm.com/index.php?rid=3154770&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0815%2F0815.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Imidazoles (intravaginal): One systematic review added comparing intravaginal imidazoles versus oral fluconazole or itraconazole. The review found no significant difference between intravaginal treatment and oral treatment in clinical cure at short- and long-term follow-up, or mycological cure at short-term follow-up. However, intravaginal imidazoles were less effective than oral treatment with fluconazole or itraconazole for achieving long-term mycological cure. Categorisation of intravaginal imidazoles unchanged (Beneficial). Fluconazole (oral): One systematic review added comparing oral fluconazole versus oral itraconazole. The review found no significant difference between groups for clinical or mycolog... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3154770 Tue, 05 Jan 2010 23:00:00 +0100 3154770 http://www.medworm.com/index.php?rid=3154769&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fend%2F0605%2F0605.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Levothyroxine (L-thyroxine) plus liothyronine for clinical (overt) hypothyroidism One systematic review added comparing L-thyroxine alone versus a combination of L-thyroxine plus liothyronine (L-tri-iodothyronine) in people with primary hypothyroidism. The review added no further data than already included and also found no difference between groups in psychiatric symptoms. Categorisation unchanged (Unlikely to be beneficial). Levothyroxine (L-thyroxine) for subclinical hypothyroidism One systematic review added comparing thyroid hormone replacement versus placebo or no treatment. The review found that hormone replacement improved general symptoms and cognitive function compared with placebo or n... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3154769 Tue, 05 Jan 2010 23:00:00 +0100 3154769 http://www.medworm.com/index.php?rid=3154768&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0410%2F0410.jsp%3Frss%3Dtrue New evidence; conclusions changed for: CBT Two systematic reviews and one RCT added. These supersede three older previously reported systematic reviews, as they provided more information, included many of the same studies, and reached similar conclusions. Categorisation changed from Unknown effectiveness to Likely to be beneficial. Hypnotherapy Two systematic reviews added. These supersede a previously reported early narrative systematic review as they include some of the same studies, provide more information, and reach similar conclusions. One of the new systematic reviews carried out a meta-analysis and found that hypnotherapy reduced global symptoms or abdominal pain compared with placebo.Categorisation changed ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3154768 Tue, 05 Jan 2010 23:00:00 +0100 3154768 http://www.medworm.com/index.php?rid=3112963&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0806%2F0806.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Progesterone: One systematic review (2 RCTs; 281 women) found no overall improvement in premenstrual symptoms in women taking luteal-phase progesterone for 2 to 4 months compared with placebo. Categorisation changed from Trade-off between benefits and harms to Unknown effectiveness. New evidence; conclusion confirmed for: SSRIs: One systematic review and one subsequent RCT added to benefits and harms, both of which found that SSRIs improved premenstrual symptoms, but were associated with a number of adverse effects, including nausea, insomnia, headache, asthenia, and decreased libido. Categorisation unchanged (Trade-off between benefits and harms). Oral contra... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3112963 Mon, 21 Dec 2009 23:00:00 +0100 3112963 http://www.medworm.com/index.php?rid=3112962&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0316%2F0316.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Monovalent measles immunisation or combined MMR immunisation versus placebo or no immunisation: Three self-controlled case series added to harms, which found increased rates of febrile convulsions, idiopathic thrombocytopenic purpura (ITP), fever, rash, and diarrhoea after MMR immunisation. One self-controlled case series added to harms, which found no cases of aseptic meningitis after MMR immunisation containing RIT 4385 mumps immunisation strain. Categorised as Beneficial. Monovalent rubella immunisation or combined MMR immunisation versus placebo or no immunisation : One population-based study added to benefits, which found that endemic cases of rubella were rare in the USA between 2001 and 2004. One cas... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3112962 Mon, 21 Dec 2009 23:00:00 +0100 3112962 http://www.medworm.com/index.php?rid=3054420&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0817%2F0817.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Anterior colporrhaphy with mesh reinforcement versus traditional anterior colporrhaphy One systematic review updated, reporting no additional RCTs, so no new data added. Three subsequent RCTs added. One RCT found that anterior colporrhaphy with porcine skin collagen implant at 1-year follow-up was more effective than anterior colporrhaphy without implant in preventing anatomical anterior recurrence. Two RCTs found that anterior colporrhaphy with polypropylene mesh was more effective than anterior colporrhaphy without mesh in preventing cystocoele recurrence at 1 year. Categorisation unchanged (Beneficial). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3054420 Mon, 30 Nov 2009 23:00:00 +0100 3054420 http://www.medworm.com/index.php?rid=3035165&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1213%2F1213.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Endovascular coiling versus surgical clipping One follow-up report of an included RCT added, which found that endovascular coiling increased retreatment rates for the same aneurysm compared with surgical clipping at 4.5 to 12 years, but it did not assess the significance of the difference between groups. Categorisation unchanged (Beneficial). Nimodipine (oral) One systematic review updated with new data from RCTs. The review confirmed its previous conclusion that oral nimodipine reduced clinical signs of secondary ischaemic, radiological signs of cerebral infarction, and the combined outcome of dependence or death compared with placebo or no treatment. It found no significant difference in mortality between... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3035165 Mon, 23 Nov 2009 23:00:00 +0100 3035165 http://www.medworm.com/index.php?rid=3035164&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0211%2F0211.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Cilostazol One systematic review added, including RCTs already reported in this Clinical Evidence review. Evidence re-evaluated. Categorisation changed from Trade-off between benefits and harms to Likely to be beneficial. New evidence; conclusion confirmed for: Antiplatelet agents One systematic review added, reporting that antiplatelet agents (aspirin or aspirin plus dipyridamole) reduced arterial occlusion of both venous and artificial peripheral bypass grafts versus placebo at 12 months. It found no significant difference in GI adverse effects, or major bleeding between groups. One RCT added, reporting lower MI rates with clopidogrel plus aspirin versus placebo plus aspirin after 26 m... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3035164 Mon, 23 Nov 2009 23:00:00 +0100 3035164 http://www.medworm.com/index.php?rid=3032214&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fent%2F0509%2F0509.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Intranasal antihistamines (azelastine) Four RCTs added comparing intranasal azelastine versus placebo. Three of the RCTs found that azelastine reduced nasal symptom severity compared with placebo, but one found no significant difference between groups.Two further RCTs added, which found no significant difference between azelastine and oral cetirizine in nasal symptom severity; one of the RCTs found that azelastine improved quality of life scores compared with cetirizine.One small RCT added comparing azelastine with oral loratadine, which found no significant difference between groups in nasal symptom severity.Categorisation changed (from Unknown effectiveness to Ben... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3032214 Wed, 18 Nov 2009 23:00:00 +0100 3032214 http://www.medworm.com/index.php?rid=3032215&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fent%2F0506%2F0506.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Antidepressant drugs for tinnitus One RCT added comparing sertraline (25 mg/day for 1 week followed by 50 mg/day for 15 weeks) versus placebo. It found that sertraline improved tinnitus severity and loudness, clinician-rated anxiety, participant-rated anxiety, and participant-rated depression compared with placebo. However, it found no significant difference between sertraline and placebo in tinnitus annoyance and clinician-rated depression. Considering all evidence reported, potential benefits of antidepressant drugs in the treatment of tinnitus are unclear. Categorisation changed from Trade-off between benefits and harms to Unknown effectiveness. New evidence; conclusion confirmed for: ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3032215 Thu, 12 Nov 2009 23:00:00 +0100 3032215 http://www.medworm.com/index.php?rid=2975266&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdia%2F0608%2F0608.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2975266 Mon, 09 Nov 2009 23:00:00 +0100 2975266 http://www.medworm.com/index.php?rid=2968949&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fhiv%2F0920%2F0920.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Early initiation of highly active antiretroviral treatment Two cohort studies added. One prospective study found mortality was increased the longer HAART initiation was delayed after starting antituberculosis treatment, and found decreased mortality in people with bacteriologically confirmed tuberculosis, who started HAART within the first 120 days of antituberculosis treatment versus people who started HAART later than this. Another study (retrospective from 1996 to 2000; prospective from 2000 to 2004) found better survival in people who started HAART within 2 months of starting antituberculous treatment versus people who started HAART more than 3 months after antituberculous treatment.Categorisation unchanged (un... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2968949 Thu, 05 Nov 2009 23:00:00 +0100 2968949 http://www.medworm.com/index.php?rid=2932718&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwnd%2F1903%2F1903.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Alginate dressing One systematic review added (search date 2008), which found no RCTs that met Clinical Evidence inclusion criteria. Categorisation unchanged (Unknown effectiveness). Chlorhexidine-impregnated paraffin gauze dressing One systematic review added (search date 2008), which did not pool data, and found no additional RCTs to those previously reported in this Clinical Evidence review. Categorisation unchanged (Unknown effectiveness). Foam dressing One systematic review added (search date 2008),which found no RCTs. Categorisation unchanged (Unknown effectiveness). Hydrocolloid dressing One systematic review added (search date 2008), which did not pool data and fo... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2932718 Tue, 27 Oct 2009 23:00:00 +0100 2932718 http://www.medworm.com/index.php?rid=2932721&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1017%2F1017.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Single- or multiple-session brief intervention in hazardous or harmful drinkers in primary care One systematic review and one subsequent RCT added comparing single- or multiple-session brief interventions with either control or extended interventions. Categorisation unchanged (Beneficial). Brief intervention (single- or multiple-session) in emergency departments One systematic review and one subsequent RCT added comparing single-session brief intervention (BI) with control. The review found no significant difference between single-session BI and control in quantity of or frequency of alcohol consumption, but found that single-session BI significantly decreased the number of alcohol-related injuries compared... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2932721 Mon, 26 Oct 2009 23:00:00 +0100 2932721 http://www.medworm.com/index.php?rid=2932720&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fknd%2F2004%2F2004.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Statins versus placebo or no treatment One systematic review and two subsequent RCTs added. The review found that statins reduced all-cause mortality and cardiovascular mortality compared with placebo or no treatment. The first subsequent RCT found that simvastatin decreased all-cause mortality, major coronary events, and the composite outcome of death from coronary disease and non-fatal MI compared with placebo. The second subsequent RCT found no significant difference between pravastatin and placebo or no treatment in rates of progression to end-stage renal disease (ESRD), composite outcome of ESRD or 50% decrease in glomerular filtration rate (GFR), or the composite outcome of ESRD or 25% decrease in GFR. Categor... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2932720 Mon, 26 Oct 2009 23:00:00 +0100 2932720 http://www.medworm.com/index.php?rid=2932719&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fent%2F0503%2F0503.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Tonsillectomy versus no surgery in adults One systematic review added identifying one RCT that met Clinical Evidence inclusion criteria. The RCT found that tonsillectomy reduced the frequency and duration of sore throat at 5 to 6 months, but had short follow-up. Categorisation unchanged (Trade-off between benefits and harms). New evidence; conclusion confirmed for: Tonsillectomy versus no surgery in children One systematic review updated (4 RCTs; 564 children), which found that tonsillectomy reduced the number of episodes of sore throat, and duration of sore throat compared with standard care at 1 to 3 years. Categorisation unchanged (Trade-off between benefits and harms). (Source: Clini... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2932719 Mon, 26 Oct 2009 23:00:00 +0100 2932719 http://www.medworm.com/index.php?rid=2860445&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0406%2F0406.jsp%3Frss%3Dtrue New option(s) added for: H pylori eradication treatments (quadruple regimens compared with triple regimens as second-line treatment) New option for which we found three RCTs. The RCTs found that quadruple regimens as second-line therapies were more effective than triple regimens at eradicating H pylori. Most triple regimens given did not contain a nitroimidazole. Categorised as Likely to be beneficial. H pylori eradication treatments (sequential regimens compared with triple regimens as first-line treatment) New option for which we found one systematic review. The review found sequential therapy was more effective at increasing H pylori eradication rates compared with proton pump inhibitor triple regimen... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2860445 Thu, 01 Oct 2009 23:00:00 +0100 2860445 http://www.medworm.com/index.php?rid=2826253&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1710%2F1710.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Photodynamic treatment One systematic review added. It found that photodynamic treatment was more effective at wart clearance than placebo or cryotherapy, and that neutral red photodynamic treatment and proflavine photodynamic treatment have similar effects. Categorisation unchanged (Likely to be beneficial). Intralesional bleomycin Data from one systematic review updated, and one RCT added. The RCT found that intralesional bleomycin increased wart clearance compared with placebo. Categorisation unchanged (unknown effectiveness). Duct tape occlusion One systematic review and two RCTs (3 publications) added. The systematic review found no significant difference in wart c... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2826253 Thu, 24 Sep 2009 16:44:22 +0100 2826253 http://www.medworm.com/index.php?rid=2826256&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1704%2F1704.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Oral antiviral agents to prevent recurrence One systematic review added (search date 2008),which did not pool data. It found three RCTs and one pooled analysis of two further RCTs that were already reported in this Clinical Evidence review. No new data added from the new review. Categorisation unchanged (Likely to be beneficial). Topical antiviral agents to prevent recurrence One systematic review added (search date 2008), which identified two RCTs. The review did not pool data, and the results of the RCT were reported from the original papers. Benefits and harms section enhanced. Categorisation unchanged (Unknown effectiveness). Sunscreen One systematic review added (search date... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2826256 Wed, 23 Sep 2009 23:00:00 +0100 2826256 http://www.medworm.com/index.php?rid=2826255&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Find%2F0916%2F0916.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Universal vaccination of infants Two observational studies added, which found that universal vaccination of infants reduced the proportion of hepatitis B carriers compared with no vaccination. Categorised as Beneficial. Selective vaccination of high-risk individuals No new evidence on effects of selective vaccination of high-risk individuals. One retrospective cohort study added to harms found no evidence of a link between autoimmune thyroid disease and hepatitis B vaccine. Categorised as Likely to be beneficial. Universal vaccination of infants No new evidence on the effects of universal vaccination of infants added. One retrospective cohort study added to harms found no eviden... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2826255 Wed, 23 Sep 2009 23:00:00 +0100 2826255 http://www.medworm.com/index.php?rid=2802289&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Feyd%2F0709%2F0709.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Glasses One cohort study added found that visual acuity was better at 1 year in over two-thirds of children who wore glasses. Categorisation unchanged (Likely to be beneficial, based on consensus). Occlusion (patching) Three systematic reviews added identified the same RCTs as previously found by Clinical Evidence. One further RCT identified found no significant difference in visual acuity at 18 weeks between 12 and 6 hours' prescribed occlusion, but added to the evidence for a dose response when actual hours of received occlusion can be measured. Categorisation unchanged; occlusion in combination with penalisation and near-vision tasks categorised as Beneficial compared with glasses alo... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2802289 Wed, 16 Sep 2009 23:00:00 +0100 2802289 http://www.medworm.com/index.php?rid=2798530&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0206%2F0206.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Anticoagulants in addition to antiplatelet treatments: Two systematic reviews added comparing intensive warfarin plus aspirin versus aspirin alone. Both reviews found that warfarin plus aspirin decreased the risk of non-fatal MI and stroke, but increased the risk of major bleeding compared with aspirin alone in people with acute coronary syndrome. The evidence supports the recategorisation from Likely to be ineffective or harmful to Trade-off between benefits and harms. Fish oil consumption (from oily fish or capsules): Two systematic reviews added comparing advice to increase fish oil consumption or fish oil consumption versus control. The reviews found that increased fish oil consumptio... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2798530 Mon, 07 Sep 2009 23:00:00 +0100 2798530 http://www.medworm.com/index.php?rid=2776378&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1004%2F1004.jsp%3Frss%3Dtrue New option(s) added for: Behavioural therapy in children and adolescents New option added, for which we found no data satisfying Clinical Evidence inclusion criteria. Categorised as Unknown effectiveness. Cognitive therapy or CBT in children and adolescents New option added, for which one systematic review and two RCTs were added. The systematic review found that CBT improved OCD symptoms versus waiting list control or placebo. However, it found no significant difference between CBT and SRIs. One RCT found no significant difference between intensive once a weekday CBT and once-weekly CBT in improvement of OCD symptoms. Categorised as Beneficial. SRIs in children and adolescents New option added, for which two systemati... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2776378 Thu, 03 Sep 2009 23:00:00 +0100 2776378 http://www.medworm.com/index.php?rid=2732108&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0220%2F0220.jsp%3Frss%3Dtrue New condition. New option(s) added for: Prompting mechanisms New option. Ten systematic reviews identified (search date 1996;search date 2000;search date 2002; search date 2003; search date 2004 ), which did not pool data. The reviews identified seven RCTs of sufficient quality and we found one subsequent RCT.Five RCTs compared various prompting mechanisms versus usual care; two RCTs compared a prompting mechanism plus usual care versus unit-of-use packaging plus usual care, unit-of-use packaging plus prompting mechanism plus usual care, or usual care alone; and the remaining RCT compared a prompting ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2732108 Mon, 24 Aug 2009 23:00:00 +0100 2732108 http://www.medworm.com/index.php?rid=2728368&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Feyd%2F0710%2F0710.jsp%3Frss%3Dtrue New option(s) added for: Corticosteroid injection during vitrectomy surgery New option added for which we identified one RCT. The RCT found no significant difference between adjunctive triamcinolone acetonide and no adjunctive treatment in retinal re-attachment rate or visual acuity at 6 months. Categorised as Unknown effectiveness. Daunorubicin infusion during vitrectomy surgery New option added for which we found two RCTs. Both RCTs found no significant difference between adding daunorubicin and not adding daunorubicin in rate of retinal re-attachment and in visual acuity. One RCT found that a smaller proportion of people in the daunorubicin group required further vitreoretinal surgery within 1 year after initial surgery com... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2728368 Wed, 19 Aug 2009 23:00:00 +0100 2728368 http://www.medworm.com/index.php?rid=2728367&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Feyd%2F0703%2F0703.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Laser trabeculoplasty plus topical medical treatment (in people with primary open-angle glaucoma, ocular hypertension, or both) One systematic review added. It identified one RCT already included in this Clinical Evidence review, so no new data added. Categorisation unchanged (Likely to be beneficial). Topical medical treatment (in people with primary open-angle glaucoma, ocular hypertension, or both) Two systematic reviews added. One review found reduced visual field loss progression with topical medical treatment (beta-blockers, dorzolamide, or unspecified) versus placebo or no treatment at 2 to 3 years' follow-up. The other review found no significant difference in visual field loss progression ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2728367 Wed, 19 Aug 2009 23:00:00 +0100 2728367 http://www.medworm.com/index.php?rid=3032216&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1123%2F1123.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Adding different immunosupressants to corticosteroids: Three systematic reviews added. The first two reviews compared mycophenolate mofetil versus cyclophosphamide, and found that mycophenolate mofetil significantly improved rates of complete or partial remission, and significantly reduced the rate of relapse compared with cyclophosphamide. The third review compared mycophenolate mofetil versus cyclophosphamide, or cyclophosphamide plus azathioprine. The review found no significant differences for any comparison for complete remission, renal survival, or relapse rate. However, the review found that mycophenolate mofetil significantly improved survival rate compared with cyclophosphamide. Categor... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3032216 Fri, 24 Jul 2009 23:00:00 +0100 3032216 http://www.medworm.com/index.php?rid=2647193&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1015%2F1015.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Buprenorphine for stabilisation: One systematic review that searched for systematic reviews and RCTs added. The systematic review found no new evidence that met our reporting criteria. The systematic review did not perform a meta-analysis for buprenorphine versus placebo but reported that the reviews found buprenorphine was more effective at retaining people in treatment (with higher doses being more effective than lower doses) and at reducing opiate use compared with placebo or no drug treatment. Categorisation of Buprenorphine versus placebo unchanged (Beneficial). The systematic review carried out a meta-analysis for buprenorphine versus methadone and found that flexible dosing regimens of buprenorphine were less effectiv... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2647193 Fri, 24 Jul 2009 23:00:00 +0100 2647193 http://www.medworm.com/index.php?rid=2628351&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1205%2F1205.jsp%3Frss%3Dtrue New option(s) added for: Anticonvulsant drugs New option added, for which we found no systematic review or RCTs. Categorised as Unknown effectiveness. Spinal manipulation (chiropractic and osteopathic treatment) Two systematic reviews and one further RCT added to benefits and harms. One RCT identified by one review found greater reduction in headache severity after treatment with palpatory examination plus osteopathic manipulation versus palpatory examination alone or versus instruction to rest in people with muscle tension-type headache. One RCT identified by both reviews found a reduction in headache intensity with amitriptyline versus spinal manipulation after 6 weeks’ treatment, but no significant reduction in headache f... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2628351 Wed, 22 Jul 2009 23:00:00 +0100 2628351 http://www.medworm.com/index.php?rid=2628352&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1712%2F1712.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Topical allylamines (naftifine, terbinafine): One already reported systematic review updated and two RCTs added. The updated review confirmed previous conclusions, and found naftifine and terbinafine were more effective at curing athlete's foot (defined as negative results on microscopy and no growth of dermatophytes in culture) compared with placebo, but not significantly different compared with each other. It found that the results for cure rates between allylamines and azoles were inconclusive. The RCTs found that topical allylamines were more effective than placebo at curing fungal skin infections. Categorisation unchanged (Beneficial). Topical azoles: One already reported systemati... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2628352 Mon, 20 Jul 2009 23:00:00 +0100 2628352 http://www.medworm.com/index.php?rid=2607947&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fspc%2F2405%2F2405.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2607947 Thu, 16 Jul 2009 23:00:00 +0100 2607947 http://www.medworm.com/index.php?rid=2565462&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0218%2F0218.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Counselling people to increase physical activity versus no counselling: effects on level of physical activity One systematic review and three RCTs added to the existing reporting of three systematic reviews and 12 RCTs. The added systematic review did not pool data in our group of interest, and the three RCTs were therefore reported separately. Two of the added RCTs found that counselling increased physical activity, whereas the third found no significant difference among groups in physical activity. Categorisation unchanged (Likely to be beneficial). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2565462 Thu, 25 Jun 2009 23:00:00 +0100 2565462 http://www.medworm.com/index.php?rid=2565463&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1122%2F1122.jsp%3Frss%3Dtrue New option(s) added for: Intra-articular injections (of hyaluronan or corticosteroid) New option for which we found no systematic review or RCTs in people with osteoarthritis of the hip. Categorised as Unknown effectiveness. Hip resurfacing New option for which we found no systematic review or RCTs in people with osteoarthritis of the hip. Categorised as Unknown effectiveness. Arthroscopic debridement New option for which we found no systematic review or RCTs in people with osteoarthritis of the hip. Categorised as Unknown effectiveness. New evidence; conclusion confirmed for: Acupuncture One systematic review added, which found no new evidence on the effects of acupuncture in people with o... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2565463 Wed, 24 Jun 2009 23:00:00 +0100 2565463 http://www.medworm.com/index.php?rid=2518867&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fbly%2F2404%2F2404.jsp%3Frss%3Dtrue New option(s) added for: ABVD plus radiotherapy versus radiotherapy alone (stage I or II non-bulky Hodgkin's lymphoma) New option added for which we found one RCT. The RCT found that two cycles of ABVD plus radiotherapy improved freedom from treatment failure (composite outcome), and reduced risk of relapse at 7 years. However, the RCT found no significant difference between treatments in overall survival at 7 years. Categorised as Likely to be beneficial by consensus (ABVD plus radiotherapy is considered the international gold standard for early-stage Hodgkin's lymphoma). New evidence; conclusion confirmed for: ABVD (stage II [bulky], III, or IV Hodgkin's lymphoma) One RCT added found that ABVD may be more effective than Sta... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2518867 Mon, 15 Jun 2009 23:00:00 +0100 2518867 http://www.medworm.com/index.php?rid=2518868&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0315%2F0315.jsp%3Frss%3Dtrue New option(s) added for: Advice to promote room sharing (without bed sharing): We found no direct evidence on the effects of room sharing (without bed sharing) on the prevention of SIDS. Categorised as Unknown effectiveness. New evidence; conclusion confirmed for: Advice to avoid prone sleeping : One retrospective cohort study added assessing the change in incidence of SIDS in the 20 years since advice to avoid prone position sleeping campaign. The study found that factors contributing to SIDS have changed during this time period. Two observational studies added to the harms section assessing the effects of supine sleeping position on deformational plagiocephaly. The first observational study documented a temporal r... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2518868 Fri, 05 Jun 2009 23:00:00 +0100 2518868 http://www.medworm.com/index.php?rid=2460645&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fsld%2F2301%2F2301.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Nasal CPAP (severe OSAHS) Three systematic reviews and three subsequent RCTs added comparing nasal CPAP versus placebo, no treatment, or conservative treatment. They found different results on blood pressure with CPAP versus placebo, no treatment, or conservative treatment. They found reduced daytime sleepiness and sleep disturbance, but no significant difference in performance in some neuropsychological test components with CPAP versus placebo, no treatment, or conservative treatment. Categorisation unchanged (Beneficial). Measures aimed at improving compliance with nasal CPAP (severe OSAHS) One RCT added comparing ongoing CPAP treatment versus switching to bi-level ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2460645 Thu, 04 Jun 2009 23:00:00 +0100 2460645 http://www.medworm.com/index.php?rid=2460646&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1405%2F1405.jsp%3Frss%3Dtrue New option(s) added for: Acupressure for treating hyperemesis gravidarum: One RCT added, which found that acupressure was more effective at reducing nausea and vomiting episodes compared with placebo and control (conventional intravenous fluid). Categorised as Likely to be beneficial. Metoclopramide for treating hyperemesis gravidarum: One RCT found that metoclopramide was less effective at reducing vomiting episodes and readmission to the intensive care unit compared with corticosteroids. Other drugs and interventions may be more useful. Categorised as Unlikely to be beneficial. New evidence; conclusion confirmed for: Acupressure for treating nausea and vomiting in early pregnancy: One systematic review an... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2460646 Wed, 03 Jun 2009 23:00:00 +0100 2460646 http://www.medworm.com/index.php?rid=2429889&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fseh%2F1605%2F1605.jsp%3Frss%3Dtrue New option(s) added for: Patient-delivered partner therapy New option for which we found one review. The review found that supplementing patient referral with patient-delivered partner therapy reduced risk of recurrent or persistent infection in index patients compared with patient referral alone. Categorised as Likely-to-be-beneficial. Health education plus counselling New option for which we found two reviews. One published RCT identified by the reviews found that more male index patients who received individual counselling plus health education reported that their partners were treated, compared with those male patients receiving simple patient referral. However, the RCT found similar rates between groups in the number of partners re... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2429889 Wed, 20 May 2009 23:00:00 +0100 2429889 http://www.medworm.com/index.php?rid=2419628&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1202%2F1202.jsp%3Frss%3Dtrue New option(s) added for: Natalizumab in people with relapsing and remitting multiple sclerosis: Two RCTs identified. One RCT found the proportion of relapse-free people at 2 years was higher with natalizumab compared with placebo. The other RCT also found that the proportion of relapse-free people at 2 years and the cumulative probability of sustained disability progression at 2 years was higher with natalizumab plus interferon beta-1a compared with interferon beta-1a alone. However, the long-term benefits and risks of natalizumab are still unknown. Categorised as Trade-off between benefits and harms. Natalizumab in people with acute relapse of multiple sclerosis: One RCT identified, which found no significant difference in Expanded Di... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2419628 Thu, 14 May 2009 23:00:00 +0100 2419628 http://www.medworm.com/index.php?rid=2371479&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0216%2F0216.jsp%3Frss%3Dtrue New option(s) added for: Defibrillation (biphasic compared with monophasic shock) New option for which we found five RCTs and one subsequent analysis comparing biphasic versus monophasic defibrillation. The RCTs found no significant differences between groups in survival, but the studies may be underpowered to show clinically important differences. Overall, the evidence found that biphasic shock increased the number of successful defibrillations compared with monophasic shock for out-of-hospital cardiac arrests. Categorised as Likely to be beneficial. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2371479 Fri, 24 Apr 2009 23:00:00 +0100 2371479 http://www.medworm.com/index.php?rid=2518869&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fknd%2F2003%2F2003.jsp%3Frss%3Dtrue New option(s) added for: Alpha-blockers in people with symptomatic ureteric stones New option for which we found two systematic reviews and three subsequent RCTs, which all found that alpha-blockers increased the proportion of people with expelled stones compared with placebo at times ranging from 1 to 7 weeks. However, both systematic reviews reported heterogeneity among RCTs. Categorised as Likely to be beneficial. New evidence; conclusion confirmed for: Extracorporeal shockwave lithotripsy (ESWL) in people with renal stones One systematic review added, which found no significant difference in treatment success rates between ESWL using 120 shocks per minute and 60 shocks per m... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2518869 Tue, 21 Apr 2009 23:00:00 +0100 2518869 http://www.medworm.com/index.php?rid=2356877&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Frdc%2F1504%2F1504.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Preoperative chemotherapy in resectable non-small cell lung cancer Two systematic reviews and one subsequent RCT added comparing preoperative chemotherapy versus surgery alone. The first review found that preoperative chemotherapy significantly increased 5-year survival compared with surgery alone. The second review found that preoperative chemotherapy significantly increased survival at 1 and 3 years, but not at 5 years compared with surgery alone. The subsequent RCT found no significant difference between groups for 5-year survival. Categorisation changed (from Unknown effectiveness to Trade-off between benefits and harms). First-line platinum-based chemotherapy versus non-platinum regimens in u... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2356877 Tue, 21 Apr 2009 23:00:00 +0100 2356877 http://www.medworm.com/index.php?rid=2343876&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1406%2F1406.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Salpingectomy: One retrospective cohort study added comparing expectant management versus salpingectomy. It found that salpingectomy did not increase the rate of subsequent pregnancy compared with expectant management. Categorisation unchanged (Beneficial). Salpingotomy: One systematic review updated, comparing salpingotomy by laparoscopy versus salpingotomy by laparotomy. It found that laparoscopy was less effective in achieving primary treatment success (elimination of tubal pregnancy) than laparotomy. However, it found no significant difference between groups in tubal patency, rate of subsequent pregnancy, and repeat ectopic pregnancy.Categorisation unchanged (Unknown effectiveness). Sy... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2343876 Mon, 20 Apr 2009 16:15:44 +0100 2343876 http://www.medworm.com/index.php?rid=2343877&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1007%2F1007.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Compliance therapy One systematic review added found no significant difference in the proportion of non-compliant people between those receiving compliance therapy and those receiving non-specific counselling therapy over 1 year. One RCT comparing adherence therapy versus health education found no significant difference between groups in either patient-rated or keyworker-rated measures of compliance at 12 months. Reassessment of evidence resulted in change of categorisation from Likely to be beneficial to Unknown effectiveness. New evidence; conclusion confirmed for: Continuation of antipsychotic drugs (to reduce relapse rates) One systematic review added found that, in the longer term (... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2343877 Thu, 16 Apr 2009 23:00:00 +0100 2343877 http://www.medworm.com/index.php?rid=2334753&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0808%2F0808.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Serotonin reuptake inhibitors (duloxetine) One systematic review updated to now include one further RCT. One subsequent RCT added, which found reduced incontinence episode frequency but no significant improvement in quality of life with duloxetine compared with placebo. Categorisation changed (Beneficial to Likely to be beneficial). Non-tension-free vaginal tape/transobturator foramen tape suburethral slings One systematic review updated. One RCT added comparing suburethral slings other than tension-free vaginal tape (TVT) versus open retropubic colposuspension, found that non-TVT suburethral autologous sling improved overall urinary incontinence and specific urinary incontinence measures at 2 years' follow-... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2334753 Tue, 14 Apr 2009 23:00:00 +0100 2334753 http://www.medworm.com/index.php?rid=2334752&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Find%2F0904%2F0904.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Rifampicin plus isoniazid Two subsequent RCTs added to the existing reporting of one systematic review. One of the subsequent RCTs (470 people) was quasi-randomised, and the other RCT was small (105 people). Categorisation unchanged (Trade-off between benefits and harms). Regimens containing quinolones One already reported systematic review updated (search date 2007) to now include one further RCT, which was already reported in this review. Reporting in benefits and harms enhanced. Two other systematic reviews added (search dates 2006), which were narrative in character, and did not pool data. No further data added from these two reviews. Overall conclusions similar to before. Categorisat... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2334752 Tue, 14 Apr 2009 23:00:00 +0100 2334752 http://www.medworm.com/index.php?rid=2311437&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fbly%2F2402%2F2402.jsp%3Frss%3Dtrue New option(s) added for: Blood transfusion (prophylactic) sickle cell disease New option for which we found one systematic review identifying two RCTs. The review found that prophylactic blood transfusion significantly reduced the rate of stroke compared with standard care or no transfusion at 16–24 months. Categorised as a Trade-off between benefits and harms. New evidence; conclusions changed for: Piracetam for sickle cell disease We found one systematic review comparing piracetam versus placebo. The review included three RCTs, but only one was reported fully. This RCT found that piracetam significantly reduced the incidence of sickle cell crisis compared with placebo. Categorisation changed from Likely to be beneficial ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2311437 Fri, 27 Mar 2009 23:00:00 +0100 2311437 http://www.medworm.com/index.php?rid=2311440&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1113%2F1113.jsp%3Frss%3Dtrue New option(s) added for: Vitamin E for leg cramps in pregnancy New option for which we identified no RCTs. Categorised as Unknown effectiveness. New evidence; conclusions changed for: Quinine A drug safety alert has been issued by the FDA advising manufacturers to stop marketing unapproved drug products containing quinine, because of serious safety concerns. Among the adverse effects of quinine are cardiac arrhythmias, thrombocytopenia, severe hypersensitivity reactions, and death. Because of these serious adverse effects, and because the toxic dose for quinine is only slightly higher than the therapeutic dose, the FDA has suggested that people should be warned against treating their leg cramps with quinine products. The FDA ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2311440 Thu, 26 Mar 2009 23:00:00 +0100 2311440 http://www.medworm.com/index.php?rid=2311438&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1118%2F1118.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Cytokine inhibitors Follow-up data for 1 year was added to the RCT comparing infliximab versus placebo, and found no significant difference in pain, disability, cumulative sick leave, or proportion of people having discectomy. Categorisation unchanged (unknown effectiveness). Spinal manipulation One RCT added comparing manipulation alone versus acupuncture plus manipulation. Evaluated after 20 sessions, it found manipulation alone was less effective at improving pain. Categorisation unchanged (likely to be beneficial). Acupuncture One RCT added comparing acupuncture plus manipulation versus manipulation alone. Evaluated and found improvements in pain after 20 sessions. However, overall evi... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2311438 Thu, 26 Mar 2009 23:00:00 +0100 2311438 http://www.medworm.com/index.php?rid=2289219&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Forh%2F1304%2F1304.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Antifungal prophylaxis in adults having chemotherapy or radiotherapy One systematic review updated, which identified no additional RCTs. Categorisation unchanged (Beneficial). Antifungal treatment in adults having chemotherapy and radiotherapy One systematic review updated which identified no additional RCTs. Categorisation unchanged (Unknown effectiveness). Antifungal prophylaxis in people with HIV infection One systematic review added comparing antifungal prophylaxis versus placebo. It found that fluconazole, itraconazole, and nystatin all reduced rates of oral candidiasis compared with placebo at times between 1 week and 35 months. Categorisation unchanged (Beneficial) ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2289219 Wed, 18 Mar 2009 23:00:00 +0100 2289219 http://www.medworm.com/index.php?rid=2264794&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1207%2F1207.jsp%3Frss%3Dtrue New option(s) added for: Ablative neurosurgical techniques to the Gasserian ganglion (retrogasserian percutaneous radiofrequency thermocoagulation, glycerol rhizolysis, or balloon compression: New option for which we found no RCTs. Categorised as Unknown effectiveness, although there is some observational evidence suggesting that radiofrequency thermocoagulation may offer higher rates of complete pain relief than glycerol rhizolysis and stereotactic radiosurgery, although it is also associated with the highest rate of complications. New evidence; conclusions changed for: Microvascular decompression New observational data and awareness of consensus that microvascular surgery is effective at reducing symptoms in the lo... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2264794 Thu, 12 Mar 2009 23:00:00 +0100 2264794 http://www.medworm.com/index.php?rid=2264793&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1018%2F1018.jsp%3Frss%3Dtrue New condition. New option(s) added for: Corticosteroids New option. One systematic review found (search date 2003) which identified no RCTs comparing corticosteroids versus no corticosteroids.Three systematic reviews found (search date 2003, search date 2004) which identified the same small RCT (48 people) comparing corticosteroids versus corticosteroids plus whole-brain radiotherapy. 'Corticosteroids' categorised as Likely to be beneficial (categorisation made by consensus as insufficient RCT evidence found). Cytotoxic chemotherapy (systemic) New option. Three RCTs identified comparing either carboplatin plus whole-brain radiotherapy (WBRT) versus WBRT aloneor temozolomide plus WBRT versus WBRT alone. Two of the RCTs we... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2264793 Thu, 12 Mar 2009 23:00:00 +0100 2264793 http://www.medworm.com/index.php?rid=2264792&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Find%2F0911%2F0911.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Amantadine (oral) chemoprophylaxis One systematic review added comparing amantadine versus placebo in people aged up to 18 years, and in elderly people.None of the RCTs included in the review met our inclusion criteria. Amantadine has been associated with insomnia, hallucinations, and agitation. There is also consensus that amantadine should not be used for first-line chemoprophylaxis, because resistance to amantadine is high and it is only effective against influenza A. Categorisation changed (from Likely to be ineffective or harmful to Trade-off between benefits and harms). Rimantadine (oral) to treat influenza One systematic review added comparing rimantadine versus placebo in children and elderly people.... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2264792 Thu, 12 Mar 2009 23:00:00 +0100 2264792 http://www.medworm.com/index.php?rid=2264795&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1112%2F1112.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Different Methods of bone fixation One RCT addedcomparing percutaneous Kirschner-wire fixation with internal screw fixation following distal chevron osteotomy found no significant differences between functional status or radiological findings at 6 months' follow-up.Categorisation unchanged (Unknown effectiveness). Distal metatarsal osteotomy Two subsequent RCTs added: One RCT comparing Lindgren osteotomy with distal chevron osteotomy found significant improvements in radiological outcomes with Lindgren osteotomy compared with distal chevron osteotomy after 1 year and 3–6 years' follow-up. The second RCT comparing scarf osteotomy with distal chevron osteotomy found no significant difference in fun... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2264795 Wed, 11 Mar 2009 23:00:00 +0100 2264795 http://www.medworm.com/index.php?rid=2264797&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1011%2F1011.jsp%3Frss%3Dtrue This study had a high withdrawal rate, which limits the conclusions that can be drawn. Categorisation unchanged (Unknown effectiveness). SSRIs Three systematic reviews added, which did not pool data, and which identified three RCTs comparing fluoxetine or citalopram versus placebo which were previously reported in this review. No new data added from the reviews. One RCT comparing fluoxetine plus CBT versus placebo plus CBT added which had a high withdrawal rate which limited any conclusions that could be drawn. Categorisation unchanged (Unknown effectiveness). Anxiolytic drugs (benzodiazepines, older-generation antipsychotics, atypical antipsychotics) No new RCTs added to the benefits or harms sections. One small RCT (not meeting Clini... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2264797 Tue, 10 Mar 2009 23:00:00 +0100 2264797 http://www.medworm.com/index.php?rid=2264796&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0321%2F0321.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Dexamethasone (oral) versus prednisolone (oral) in children with moderate to severe croup One RCT added comparing prednisolone versus dexamethasone 0.6 mg/kg versus dexamethasone 0.15 mg/kg, all given orally. It found no significant difference among the groups in hospital admission or in the need for further medical attention. Categorisation changed (Unknown effectiveness). New evidence; conclusion confirmed for: Dexamethasone (oral), higher dose versus lower dose in children with moderate to severe croup One RCT added comparing dexamethasone 0.6 mg/kg versus dexamethasone 0.15 mg/kg versus prednisolone, all given orally. It found no significant difference among the groups in hospita... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2264796 Tue, 10 Mar 2009 23:00:00 +0100 2264796 http://www.medworm.com/index.php?rid=2264798&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0208%2F0208.jsp%3Frss%3Dtrue New option(s) added for: Self-testing and self-management of oral anticoagulation One systematic review and two subsequent RCTs added comparing self-management of oral anticoagulation versus usual care.Clinical outcomes such as mortality or recurrence were not assessed by the review It found that self-management significantly increased the proportion of INR results in the therapeutic range at 6–24 months.The first RCT found no significant difference in proportion of time spent within the INR therapeutic range between groups at 6 months.The second RCT found that self-management of oral anticoagulation increased the proportion of time spent within the INR therapeutic range compared with usual care at 6 and 12 months. New evidence; conclusions... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2264798 Mon, 09 Mar 2009 23:00:00 +0100 2264798 http://www.medworm.com/index.php?rid=2198933&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F1013%2F1013.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2198933 Fri, 13 Feb 2009 23:00:00 +0100 2198933 http://www.medworm.com/index.php?rid=2198934&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0415%2F0415.jsp%3Frss%3Dtrue New option(s) added for: Radiofrequency ablation New option. Two RCTs comparing radiofrequency ablation versus open haemorrhoidectomy, and one RCT comparing radiofrequency ablation versus rubber band ligation added.Radiofrequency ablation categorised as Unknown effectiveness. New evidence; conclusions changed for: Stapled haemorrhoidectomy Six systematic reviews added (search date 2002;search date 2004; search date 2006 ), one 7-year follow-up of an included RCT added, and five subsequent RCTs added comparing stapled haemorrhoidectomy versus conventional haemorrhoidectomy (open or closed haemorrhoidectomy, results combined in analysis) or stapled ve... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2198934 Thu, 29 Jan 2009 23:00:00 +0100 2198934 http://www.medworm.com/index.php?rid=2198935&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1201%2F1201.jsp%3Frss%3Dtrue New option(s) added for: Lamotrigine (partial epilepsy) One systematic review and one RCT added. The systematic review found that, compared with carbamazepine, lamotrigine was associated with a lower risk of treatment failure, and increased the proportion of people who were seizure free at 6 months. The RCT found lamotrigine was less likely to lead to treatment withdrawals caused by adverse effects compared with gabapentin, but we don't know whether it is more effective at increasing the proportion of people seizure free at 3 months. Categorisation amended to Likely to be beneficial by consensus (evidence not strong to support categorisaton of Beneficial by consensus). Topiramate (partial epilepsy) One RCT added. The RCT found no significant diff... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2198935 Wed, 28 Jan 2009 23:00:00 +0100 2198935 http://www.medworm.com/index.php?rid=2198936&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1407%2F1407.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: SSRIs 3 systematic reviews added, which did not perform a meta-analysis. They identified no additional RCTs. Categorisation unchanged (Likely to be beneficial). CBT (group) Two systematic reviews added, which did not perform a meta-analysis. They identified no additional RCTs. Categorisation unchanged (Unknown effectiveness). Interpersonal psychotherapy 3 systematic reviews added, which did not perform a meta-analysis. They identified no additional RCTs. Categorisation unchanged (Likely to be beneficial). Non-directive counselling One systematic review added, which did not perform a meta-analysis. It identified one additio... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2198936 Mon, 26 Jan 2009 23:00:00 +0100 2198936 http://www.medworm.com/index.php?rid=2198937&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0816%2F0816.jsp%3Frss%3Dtrue New option(s) added for: Intraperitoneal platinum-based chemotherapy versus intravenous platinum-based chemotherapy following primary cytoreductive surgery New option. Six systematic reviews identified (search date not stated; search date 2006; search date 2007)which included women with a new diagnosis of ovarian cancer following primary cytoreductive surgery, and compared intraperitoneal platinum-based chemotherapy versus intravenous platinum chemotherapy. "Intraperitoneal platinum-based chemotherapy versus intravenous platinum-based chemotherapy following primary cytoreductive surgery" categorised as Unknown effectiveness. Intraperitoneal consolidation treatment versus no further treatment in women following primary... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2198937 Fri, 16 Jan 2009 23:00:00 +0100 2198937 http://www.medworm.com/index.php?rid=2124810&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0816%2F0816.jsp%3Frss%3Dtrue New option(s) added for: Intraperitoneal platinum-based chemotherapy versus intravenous platinum-based chemotherapy following primary cytoreductive surgery New option. Six systematic reviews identified (search date not stated; search date 2006; search date 2007)which included women with a new diagnosis of ovarian cancer following primary cytoreductive surgery, and compared intraperitoneal platinum-based chemotherapy versus intravenous platinum chemotherapy. "Intraperitoneal platinum-based chemotherapy versus intravenous platinum-based chemotherapy following primary cytoreductive surgery" categorised as Unknown effectiveness. Intraperitoneal consolidation treatment versus no further treatment in women following primary... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2124810 Fri, 16 Jan 2009 23:00:00 +0100 2124810 http://www.medworm.com/index.php?rid=2124811&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F1408%2F1408.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Cyproterone acetate–ethinylestradiol : One systematic review added. The systematic review found no significant difference in hirsutism scores between metformin and cyproterone acetate–ethinylestradiol. The review found that cyproterone acetate combined with metformin was more effective over 4 months at reducing hirsutism scores compared with cyproterone acetate–ethinyloestradil alone. Categorisation unchanged (Trade-off between benefits and harms). Flutamide: Two RCTs added. The RCTs found that flutamide alone and flutamide plus metformin were more effective at reducing hirsutism scores and at improving menstrual frequency. Categorisation unchanged (Likely to be beneficial). ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2124811 Thu, 15 Jan 2009 23:00:00 +0100 2124811 http://www.medworm.com/index.php?rid=2109915&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F1408%2F1408.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Finasteride One RCT added; categorisation unchanged (Likely to be beneficial). Mechanical hair removal One RCT added; categorisation unchanged (Unknown effectiveness). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2109915 Thu, 15 Jan 2009 23:00:00 +0100 2109915 http://www.medworm.com/index.php?rid=2109917&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1703%2F1703.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Dimeticone One RCT added comparing dimeticone versus malathion. It found that dimeticone was more effective than malathion at eradicating headlice at 14 days. Categorisation changed from Unknown effectiveness to Likely to be beneficial. New evidence; conclusion confirmed for: Malathion One RCT added comparing malathion versus dimeticone. It found that malathion was less effective than dimeticone at eradicating headlice at 14 days. Categorisation unchanged (Likely to be beneficial) (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2109917 Wed, 14 Jan 2009 23:00:00 +0100 2109917 http://www.medworm.com/index.php?rid=2109916&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fend%2F0606%2F0606.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Protein restriction: One systematic review added comparing low-protein diet versus normal diet. The review did not report on outcome of interest. Categorisation unchanged (Unknown effectiveness). Protein restriction One systematic review added comparing low-protien diet versus usual diet in people with late nephropathy and type 1 diabetes. The review did not report on any outcome of interest. Categorisation unchanged (Unknown effectiveness) Protein restriction One systematic review added comparing low-protein diet versus usual diet in people with early nephropathy and type 2 diabetes. The review did not report on any outcome of interest. Categorisation unchanged (Unknown effectiveness). ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2109916 Wed, 14 Jan 2009 23:00:00 +0100 2109916 http://www.medworm.com/index.php?rid=2107189&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fend%2F0606%2F0606.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Protein restriction: One systematic review added comparing low-protein diet versus normal diet. The review did not report on outcome of interest. Categorisation unchanged (Unknown effectiveness). Protein restriction One systematic review added comparing low-protien diet versus usual diet in people with late nephropathy and type 1 diabetes. The review did not report on any outcome of interest. Categorisation unchanged (Unknown effectiveness) Protein restriction One systematic review added comparing low-protein diet versus usual diet in people with early nephropathy and type 2 diabetes. The review did not report on any outcome of interest. Categorisation unchanged (Unknown effectiveness). ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2107189 Wed, 14 Jan 2009 23:00:00 +0100 2107189 http://www.medworm.com/index.php?rid=2103843&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fspc%2F2406%2F2406.jsp%3Frss%3Dtrue New option(s) added for: 5HT3 antagonists plus corticosteroids in people with radiotherapy-related nausea and vomiting New option for which we identified one large RCT, which found that dexamethasone was more effective than placebo at reducing nausea and vomiting in people receiving 5HT3 antagonists to prevent radiotherapy-induced emesis. Combination categorised as Likely to be beneficial. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2103843 Tue, 13 Jan 2009 23:00:00 +0100 2103843 http://www.medworm.com/index.php?rid=2103841&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Find%2F0917%2F0917.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Adding intravenous immunoglobulin to standard intravenous fluids: One RCT added. The RCT found insufficient evidence in assessing the addition of intravenous immunoglobulin to standard intravenous fluids in children with secondary dengue infection. Categorisation unchanged (Unknown effectiveness). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2103841 Mon, 12 Jan 2009 23:00:00 +0100 2103841 http://www.medworm.com/index.php?rid=2103842&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0202%2F0202.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Thrombolysis One RCT added comparing lanoteplase versus alteplase tPA in people with acute MI. It found no significant difference between groups in mortality or reinfarction at 30 days. Categorisation unchanged (Beneficial). Low molecular weight heparin plus thrombolytic One RCT added comparing 7 days of enoxaparin versus 2 days of unfractionated heparin in people having thrombolysis for acute MI. It found that enoxaparin reduced the combined outcome of death and non-fatal MI at 30 days. Categorisation unchanged (Likely to be beneficial). Glycoprotein IIb/IIIa inhibitors One systematic review added comparing early versus late administration of Glycoprotein IIb/IIIa inhibi... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2103842 Fri, 09 Jan 2009 23:00:00 +0100 2103842 http://www.medworm.com/index.php?rid=2100302&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F1008%2F1008.jsp%3Frss%3Dtrue New option(s) added for: Sertraline plus CBT in adolescents New option categorised as Unknown effectiveness; we found one small RCT that found no significant difference between sertraline plus CBT and sertraline or CBT alone in rates of remission. Omega 3 polyunsaturated fatty acids New option categorised as Unknown effectiveness; we found no systematic review or RCTs on the effects of omega 3 polyunsaturated fatty acids on depression in children and adolescents. New evidence; conclusions changed for: Family therapy in children and adolescents One RCT added comparing family therapy plus usual care versus usual care alone; the RCT found a trend towards improvement in symptoms of depression for those ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2100302 Wed, 07 Jan 2009 23:00:00 +0100 2100302 http://www.medworm.com/index.php?rid=2100301&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0313%2F0313.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Oral sweet solutions One RCT added comparing both 2 mL and 0.4 mL of glucose 30% versus water. It found that 2 mL of glucose 30% reduced pain scores, the proportion of infants who cried, and duration of crying compared with water. However, it found no significant difference in pain score, number of infants who cried, or duration of crying between 0.4 mL glucose 30% and water. Categorisation unchanged (Likely to be beneficial). Topical anaesthetics Two RCTs added comparing tetracaine versus placebo. The first RCT found that tetracaine reduced pain scores compared with placebo.The second RCT found no significant difference in pain scores or duration of crying between tetracaine and placebo. Howev... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2100301 Wed, 07 Jan 2009 23:00:00 +0100 2100301 http://www.medworm.com/index.php?rid=2100305&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1703%2F1703.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Dimeticone One RCT added comparing dimeticone versus malathion. It found that dimeticone was more effective than malathion at eradicating headlice at 14 days. Categorisation changed from Unknown effectiveness to Likely to be beneficial. New evidence; conclusion confirmed for: Malathion One RCT added comparing malathion versus dimeticone. It found that malathion was less effective than dimeticone at eradicating headlice at 14 days. Categorisation unchanged (Likely to be beneficial) (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2100305 Tue, 06 Jan 2009 23:00:00 +0100 2100305 http://www.medworm.com/index.php?rid=2100304&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsh%2F1806%2F1806.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Surgical ligation One RCT added comparing varicocelectomy tecniques (open inguinal, laparoscopic, and subinguinal microscopic varicocelectomy). It found no differences between groups for rates of pregnancy at 1-year follow-up. Categorisation unchanged (Unknown effectiveness). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2100304 Tue, 06 Jan 2009 23:00:00 +0100 2100304 http://www.medworm.com/index.php?rid=2100303&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fhiv%2F0908%2F0908.jsp%3Frss%3Dtrue New option(s) added for: Clarithromycin plus clofazimine plus ethambutol (higher mortality than clofazimine plus ethambutol) New evidence; conclusion confirmed for: Antituberculosis prophylaxis versus placebo One systematic review added; categorisation unchanged (beneficial) but benefits and harms data updated. Different antituberculosis prophylactic regimens versus each other One systematic review added; categorisation unchanged (trade-off between benefits and harms) but benefits and harms data updated. Aciclovir One RCT added; categorisation unchanged (beneficial) but benefits and harms data updated. Azoles One RCT added. Categorisation unchanged (trade-off betw... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2100303 Tue, 06 Jan 2009 23:00:00 +0100 2100303 http://www.medworm.com/index.php?rid=2059311&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1711%2F1711.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Tretinoin One RCT added comparing tretinoin versus placebo cream in people with sun-damaged skin. It found that tretinoin increased the proportion of people with improved fine wrinkles at 6 months compared with placebo, but also increased skin erythema, peeling, burning, dryness, and itching. Categorisation changed (Trade-off between benefits and harms). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059311 Tue, 16 Dec 2008 23:00:00 +0100 2059311 http://www.medworm.com/index.php?rid=2059310&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1010%2F1010.jsp%3Frss%3Dtrue New evidence; conclusions changed for: CBT versus drug treatments Existing evidence re-evaluated, and reporting in benefits section further enhanced with additional detail. Existing categorisation changed. 'CBT versus antidepressants (unclear which more effective, but weak evidence that effects of CBT may last longer than those of antidepressants)' categorised as Unknown effectiveness. CBT plus drug treatments versus drugs alone One systematic review (search date 2005) added which includes a meta-analysis for short- and long-term results.Benefits and harms data enhanced. Categorisation changed. CBT plus antidepressants categorised as Likely to be beneficial compared with antidepressants alone as combination treatment may be more effective. ... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059310 Tue, 16 Dec 2008 23:00:00 +0100 2059310 http://www.medworm.com/index.php?rid=2059309&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F1119%2F1119.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059309 Tue, 16 Dec 2008 23:00:00 +0100 2059309 http://www.medworm.com/index.php?rid=2059314&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1715%2F1715.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Itraconazole (oral) One RCT added to the benefits section comparing oral pulsed itraconazole versus oral terbinafine. The RCT found no significant difference in cure rates between groups at 48 weeks. One open-label RCT added to the harms section comparing oral itraconazole versus oral terbinfine. It found no significant difference in the rate of relapse between groups. Categorisation unchanged (Beneficial). Oral terbinafine One RCT added to the benefits section comparing oral pulsed itraconazole versus oral terbinafine. The RCT found no significant difference in cure rates between groups at 48 weeks. One open-label RCT added to the harms section comparing oral itraconazole versus oral terbinfine. It found n... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059314 Mon, 15 Dec 2008 23:00:00 +0100 2059314 http://www.medworm.com/index.php?rid=2059313&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Frdc%2F1502%2F1502.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Anticholinergics versus beta2 agonists Five systematic reviews updated that found no significant differences between various anticholinergics and beta2 agonists for the majority of outcomes. One review reported that ipratropium led to small improvements in the dyspnoea, fatigue, emotion, and mastery components of the Chronic Respiratory Disease Questionnaire compared with salmeterol. One review found that tiotropium led to a larger improvement in FEV1 compared with salmeterol. Categorisation of anticholinergics versus beta2 agonists changed from Likely to be beneficial to Unknown effectiveness as both treatments are effective, and it is unclear if one is consistently more effective than... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059313 Mon, 15 Dec 2008 23:00:00 +0100 2059313 http://www.medworm.com/index.php?rid=2059312&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1410%2F1410.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Controlled cord traction One systematic review added comparing controlled cord traction alone versus minimal intervention in third stage labour. The review included two quasi-randomised trials with conflicting results, no conclusions were reported due to serious methodological flaws of the original data. Categorisation unchanged (Likely to be beneficial). Uterine massage One RCT added comparing unterine massage plus active managment versus active managment alone. It found that uterine massage reduced blood loss at 30 and 60 minutes post delivery, and reduced the need for additional uterotonic agent compared with active management. However there was no signficant difference between groups in rates of postpar... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059312 Mon, 15 Dec 2008 23:00:00 +0100 2059312 http://www.medworm.com/index.php?rid=2059315&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1012%2F1012.jsp%3Frss%3Dtrue New evidence; conclusions changed for: Nurse-led management New evidence; conclusion confirmed for: Paroxetine: One systematic review on the increased risk of suicidal behaviour associated with SSRIs added to the harms section. The review found that SSRIs increased the risk of suicide attempts compared with placebo but not compared with tricyclic antidepressants. Categorisation unchanged (Unknown effectiveness). Telephone contact : One RCT added. The RCT found that telephone contact at 1 month decreased the proportion of people repeating self-harm at 6 months compared with treatment as usual. However, there was no significant difference between the two groups at 13 months. The RCT also found no sign... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059315 Fri, 12 Dec 2008 23:00:00 +0100 2059315 http://www.medworm.com/index.php?rid=2059316&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0417%2F0417.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for: Pancreatic enzyme supplements One RCT added which found that pancreatic enzyme supplements caused a greater reduction in faecal fat from baseline to 2 weeks, compared with placebo. It found no significant difference in overall symptom relief between groups. Categorisation unchanged (Likely to be beneficial). Method of ductal decompression One RCT added which compared endoscopic ductal decompression versus surgical ductal decompression. It found that surgical decompression reduced pain at 2 years. Categorisation unchanged (Trade-off between benefits and harms). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059316 Fri, 05 Dec 2008 23:00:00 +0100 2059316 http://www.medworm.com/index.php?rid=2059318&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fsld%2F2303%2F2303.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059318 Thu, 04 Dec 2008 23:00:00 +0100 2059318 http://www.medworm.com/index.php?rid=2059317&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0411%2F0411.jsp%3Frss%3Dtrue New option(s) added for: Percutaneous, followed by early cholecystectomy v medical, followed by delayed cholecystostomy New evidence; conclusion confirmed for: Early v delayed cholecystectomy One systematic review added comparing early versus late cholecystectomy. The review found no difference between groups in the rates of conversion from laparoscopic cholecystectomy to open cholecystectomy. Categorisation unchanged (Beneficial). Laparoscopic cholecystectomy One observational study added to the comments section investigating the prevalence of persistent abdominal pain 5 years after cholecystectomy. The study found that neither the duration of symptom history prior to cholecystectomy, indication fo... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=2059317 Thu, 04 Dec 2008 23:00:00 +0100 2059317 http://www.medworm.com/index.php?rid=1973848&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1120%2F1120.jsp%3Frss%3Dtrue New evidence; conclusions confirmed for Colchicine (oral) for treating acute gout and Corticosteroids. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1973848 Mon, 17 Nov 2008 05:00:00 +0100 1973848 http://www.medworm.com/index.php?rid=1855357&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1102%2F1102.jsp%3Frss%3Dtrue New evidence; conclusions changed for NSAIDs and Back exercises. New evidence; conclusion confirmed for Analgesics, Multidisciplinary programmes (acute low back pain), Temperature treatments and Traction. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1855357 Fri, 03 Oct 2008 04:00:00 +0100 1855357 http://www.medworm.com/index.php?rid=1850199&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0312%2F0312.jsp%3Frss%3Dtrue New condition. New options added for Modafinil, Bupropion, Omega-3 polyunsaturated fatty acid compounds (fish oils), Homeopathy and Dexamfetamine sulphate + psych treatment. New evidence; conclusion changed for Clonidine. New evidence; conclusion confirmed for Atomoxetine, Dexamfetamine sulphate, Methylphenidate and Methylphenidate + psych treatment . (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1850199 Thu, 02 Oct 2008 04:00:00 +0100 1850199 http://www.medworm.com/index.php?rid=1850202&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1116%2F1116.jsp%3Frss%3Dtrue New evidence; conclusions changed for Analgesics, NSAIDs, Facet joint injections and Spinal manipulative therapy. New evidence; conclusion confirmed for Back exercises, Multidisciplinary programmes, Acupuncture, Back schools, Behavioural therapy, Traction and TENS. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1850202 Wed, 01 Oct 2008 04:00:00 +0100 1850202 http://www.medworm.com/index.php?rid=1850201&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0310%2F0310.jsp%3Frss%3Dtrue New option added for Soy formula with added fibre. New evidence; conclusions confirmed for Metoclopramide and Surgery. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1850201 Wed, 01 Oct 2008 04:00:00 +0100 1850201 http://www.medworm.com/index.php?rid=1850200&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0213%2F0213.jsp%3Frss%3Dtrue New options added for Beta-blockers plus other anti-anginal drug treatments v beta-blockers alone, Calcium channel blockers plus other anti-anginal drug treatments v calcium channel blockers alone, Nitrates plus other anti-anginal drug treatments, Potassium channel openers plus other anti-anginal drug treatments, Beta-blockers in addition to existing anti-anginal drug treatment, Calcium channel blockers in addition to existing anti-anginal drug treatment, Nitrates in addition to existing anti-anginal drug treatment and Potassium channel openers in addition to existing anti-anginal drug treatment . (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1850200 Wed, 01 Oct 2008 04:00:00 +0100 1850200 http://www.medworm.com/index.php?rid=1840248&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpoc%2F2201%2F2201.jsp%3Frss%3Dtrue New option added for Nasogastric decompression (selective versus routine). New evidence; conclusion changed for Lung expansion techniques. New evidence; conclusion confirmed for Anaesthesia. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1840248 Mon, 29 Sep 2008 04:00:00 +0100 1840248 http://www.medworm.com/index.php?rid=1840249&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1125%2F1125.jsp%3Frss%3Dtrue New condition. New options added for Warming hands and feet, Relaxation therapy, Biofeedback, Smoking cessation, Hand exercises, Glyceryl trinitrate (transdermal), Calcium channel blockers, Alpha-blockers, Naftidrofuryl oxylate , Moxisylyte, Inositol nicotinate , ACE inhibitors , Angiotensin II receptor antagonists (oral) , SRIs , Endothelin-1 receptor antagonists, Phosphodiesterase inhibitors , Antithrombotics/inhibitors of platelet aggregation , Prostaglandins (oral) and Prostaglandins (intravenous). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1840249 Fri, 26 Sep 2008 04:00:00 +0100 1840249 http://www.medworm.com/index.php?rid=1840250&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1401%2F1401.jsp%3Frss%3Dtrue New option added for Water births. New evidence; conclusion confirmed for Absorbable sutures in first- and second-degree tears, Continuous sutures in first- and second-degree tears and Third- and fourth-degree tears. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1840250 Wed, 24 Sep 2008 04:00:00 +0100 1840250 http://www.medworm.com/index.php?rid=1814711&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0805%2F0805.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Tranexamic acid, Intrauterine progestogens and Endometrial destruction. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1814711 Thu, 18 Sep 2008 04:00:00 +0100 1814711 http://www.medworm.com/index.php?rid=1814712&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0201%2F0201.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Specialised care, Aspirin, Anticoagulants, Neuroprotective agents, Blood pressure reduction and Evacuation. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1814712 Tue, 16 Sep 2008 04:00:00 +0100 1814712 http://www.medworm.com/index.php?rid=1797307&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwnd%2F1902%2F1902.jsp%3Frss%3Dtrue New options added for Advice to elevate leg, Advice to keep leg active, Advice to modify diet, Advice to stop smoking and Advice to reduce weight. New evidence; conclusion confirmed for Foam or semi occlusive dressings, Antimicrobial agents (topical), Topical negative pressure, Occlusive dressings, Pentoxifylline (oral), Sulodexide (oral), Allogenic single-layer skin replacement, Skin grafting, Superficial vein surgery to treat venous leg ulcers and Superficial vein surgery to prevent recurrence. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1797307 Mon, 15 Sep 2008 04:00:00 +0100 1797307 http://www.medworm.com/index.php?rid=1774813&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1211%2F1211.jsp%3Frss%3Dtrue New options added for Serotonergic agonists, Serotonergic antagonists, Serotonergic agonists and Serotonergic antagonists. New evidence; conclusion confirmed for Acetylcholine receptor inhibitors, Deep brain stimulation and Deep brain stimulation. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1774813 Fri, 05 Sep 2008 04:00:00 +0100 1774813 http://www.medworm.com/index.php?rid=1763232&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fknd%2F2001%2F2001.jsp%3Frss%3Dtrue New evidence; conclusion changed for Renal replacement therapy (prophylactic haemofiltration/dialysis). New evidence; conclusion confirmed for Sodium chloride-based fluids, N-Acetylcysteine, Contrast media (iso-osmolar), Fenoldopam, Calcium channel blockers, Loop diuretics, Renal replacement therapy (high-dose continuous), Renal replacement therapy and Loop diuretics. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1763232 Wed, 03 Sep 2008 04:00:00 +0100 1763232 http://www.medworm.com/index.php?rid=1763231&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0404%2F0404.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Adjuvant chemotherapy. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1763231 Wed, 03 Sep 2008 04:00:00 +0100 1763231 http://www.medworm.com/index.php?rid=1763230&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0207%2F0207.jsp%3Frss%3Dtrue New option added for Vitamin B supplements (including folate). New evidence; conclusion changed for Type of carotid endarterectomy. New evidence; conclusion confirmed for Blood pressure reduction, Cholesterol reduction, Alternatives to aspirin, Different blood pressure-lowering regimens, Aspirin dose, Anticoagulation (sinus rhythm), Carotid endarterectomy (less than 30% stenosis), Carotid endarterectomy in people with moderate (30–49%) symptomatic carotid artery stenosis, Carotid endarterectomy (50–69% stenosis), Carotid endarterectomy (more than 70% stenosis), Carotid endarterectomy (near occlusion), Carotid angioplasty , Carotid angioplasty plus stenting, Anticoagulant treatment: AF and previous stroke or TIA and Antiplatelets: AF and previous stroke or TIA. (Source: Clinical Evidenc... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1763230 Wed, 03 Sep 2008 04:00:00 +0100 1763230 http://www.medworm.com/index.php?rid=1741681&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1101%2F1101.jsp%3Frss%3Dtrue New evidence; conclusions confirmed for CBT and Dietary supplements. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1741681 Thu, 28 Aug 2008 04:00:00 +0100 1741681 http://www.medworm.com/index.php?rid=1741682&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1017%2F1017.jsp%3Frss%3Dtrue New options added for Single- or multiple-session brief intervention in primary care, Universal screening plus brief intervention in primary care, Targeted screening plus brief intervention in primary care, Single- or multiple-session brief intervention in emergency departments, Universal screening plus brief intervention in emergency departments and Targeted screening plus brief intervention in emergency departments. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1741682 Wed, 27 Aug 2008 04:00:00 +0100 1741682 http://www.medworm.com/index.php?rid=1741684&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1707%2F1707.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Permethrin (topical), Lindane (topical), Crotamiton (topical), Benzyl benzoate (topical), Malathion (topical), Sulphur compounds (topical) and Ivermectin (oral). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1741684 Fri, 22 Aug 2008 04:00:00 +0100 1741684 http://www.medworm.com/index.php?rid=1741683&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1718%2F1718.jsp%3Frss%3Dtrue New evidence; conclusions confirmed for Interferon alfa plus cytotoxic chemotherapy and Interferon alfa plus interleukin-2 plus chemotherapy. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1741683 Fri, 22 Aug 2008 04:00:00 +0100 1741683 http://www.medworm.com/index.php?rid=1741686&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1402%2F1402.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Antiplatelet drugs, Calcium supplementation, Antioxidants, Marine oil (fish oil) and other prostaglandin precursors (evening primrose oil), Antihypertensive agents, Prophylactic anticonvulsants, Antihypertensives, Interventionist care for severe early-onset pre-eclampsia, Plasma expanders and Anticonvulsants for eclampsia. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1741686 Thu, 14 Aug 2008 04:00:00 +0100 1741686 http://www.medworm.com/index.php?rid=1741685&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Feyd%2F0708%2F0708.jsp%3Frss%3Dtrue New evidence; conclusions confirmed for Manual (large or small) incision extracapsular extraction and Phaco extracapsular extraction. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1741685 Thu, 14 Aug 2008 04:00:00 +0100 1741685 http://www.medworm.com/index.php?rid=1678817&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1103%2F1103.jsp%3Frss%3Dtrue New evidence; conclusions changed for Acupuncture and Early normal activity. New evidence; conclusion confirmed for Exercise for non-specific neck pain, Traction, Mobilisation, Manipulation, Collars and pillows, Mobilisation (early) for acute whiplash injury, Physical treatments and Drug treatments for neck pain with radiculopathy. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1678817 Mon, 04 Aug 2008 04:00:00 +0100 1678817 http://www.medworm.com/index.php?rid=1678819&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fspc%2F2408%2F2408.jsp%3Frss%3Dtrue New condition. New options added for Morphine, Codeine, Dihydrocodeine, Fentanyl (transdermal), Hydromorphone, Methadone, Oxycodone and Tramadol. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1678819 Thu, 31 Jul 2008 04:00:00 +0100 1678819 http://www.medworm.com/index.php?rid=1678818&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fhiv%2F0902%2F0902.jsp%3Frss%3Dtrue New options added for Fusion inhibitors and CCR5 inhibitors. New evidence; conclusion confirmed for PEP in healthcare workers, Boosted PI-based regimens, NNRTI-based triple regimens, Standard PI based triple regimens and Early v delayed treatment. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1678818 Thu, 31 Jul 2008 04:00:00 +0100 1678818 http://www.medworm.com/index.php?rid=1670789&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdia%2F0607%2F0607.jsp%3Frss%3Dtrue New evidence; conclusion changed for Education. New evidence; conclusion confirmed for Different frequencies of insulin administration (CSII v MDI). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1670789 Wed, 30 Jul 2008 04:00:00 +0100 1670789 http://www.medworm.com/index.php?rid=1648346&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpos%2F2103%2F2103.jsp%3Frss%3Dtrue New evidence; conclusion changed for Oxygen by non-re-breather mask. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1648346 Wed, 23 Jul 2008 04:00:00 +0100 1648346 http://www.medworm.com/index.php?rid=1648345&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Feyd%2F0707%2F0707.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Aciclovir (oral) for 1 year to prevent recurrence. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1648345 Wed, 23 Jul 2008 04:00:00 +0100 1648345 http://www.medworm.com/index.php?rid=1644973&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fwoh%2F0801%2F0801.jsp%3Frss%3Dtrue New option added for Oestrogen (topical) in postmenopausal women. New evidence; conclusion confirmed for Continuous prophylaxis. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1644973 Thu, 17 Jul 2008 04:00:00 +0100 1644973 http://www.medworm.com/index.php?rid=1644972&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Frda%2F1503%2F1503.jsp%3Frss%3Dtrue New evidence; conclusion changed for Antibiotics. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1644972 Thu, 17 Jul 2008 04:00:00 +0100 1644972 http://www.medworm.com/index.php?rid=1644971&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Frda%2F1508%2F1508.jsp%3Frss%3Dtrue New option added for Analgesics. New evidence; conclusion confirmed for Expectorants. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1644971 Thu, 17 Jul 2008 04:00:00 +0100 1644971 http://www.medworm.com/index.php?rid=1644970&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Forh%2F1305%2F1305.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1644970 Thu, 17 Jul 2008 04:00:00 +0100 1644970 http://www.medworm.com/index.php?rid=1644975&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fhiv%2F2501%2F2501.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1644975 Wed, 16 Jul 2008 04:00:00 +0100 1644975 http://www.medworm.com/index.php?rid=1644974&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0412%2F0412.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Open mesh repair, TEP laparoscopic repair, TAPP laparoscopic repair, Open suture repair, Expectant management, Open mesh repair, Open mesh repair and TAPP laparoscopic repair. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1644974 Wed, 16 Jul 2008 04:00:00 +0100 1644974 http://www.medworm.com/index.php?rid=1559599&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fent%2F0510%2F0510.jsp%3Frss%3Dtrue New evidence; conclusions confirmed for Antibacterials (topical; with or without corticosteroids) and Acetic acid (topical) for treating otitis externa. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1559599 Thu, 26 Jun 2008 04:00:00 +0100 1559599 http://www.medworm.com/index.php?rid=1537622&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fseh%2F1607%2F1607.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1537622 Mon, 23 Jun 2008 04:00:00 +0100 1537622 http://www.medworm.com/index.php?rid=1524809&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdsd%2F0403%2F0403.jsp%3Frss%3Dtrue New evidence; conclusion changed for Motility stimulants. New evidence; conclusion confirmed for Lifestyle advice/modification, H2 receptor antagonists, Proton pump inhibitors, Proton pump inhibitors, Open surgery and Laparoscopy. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1524809 Fri, 13 Jun 2008 04:00:00 +0100 1524809 http://www.medworm.com/index.php?rid=1524810&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmeh%2F1009%2F1009.jsp%3Frss%3Dtrue New evidence; conclusions changed for Topiramate and Pharmacotherapy plus psychotherapy. New evidence; conclusion confirmed for CBT-BN, CBT-ERP, Pure self-help CBT and SSRIs. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1524810 Thu, 12 Jun 2008 04:00:00 +0100 1524810 http://www.medworm.com/index.php?rid=1506772&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fdia%2F0602%2F0602.jsp%3Frss%3Dtrue New option added for Debridement or wound dressings. New evidence; conclusions changed for Pressure off-loading and Pressure off-loading . New evidence; conclusion confirmed for Topical growth factors. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1506772 Tue, 10 Jun 2008 04:00:00 +0100 1506772 http://www.medworm.com/index.php?rid=1506773&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Frda%2F1510%2F1510.jsp%3Frss%3Dtrue New option added for Decongestants plus antihistamines. New evidence; conclusion confirmed for Antihistamines, Decongestants for short-term relief, Decongestants for long-term relief, Echinacea, Steam inhalation and Antibiotics. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1506773 Mon, 09 Jun 2008 04:00:00 +0100 1506773 http://www.medworm.com/index.php?rid=1474332&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fmsd%2F1117%2F1117.jsp%3Frss%3Dtrue New evidence; conclusions confirmed for Corticosteroid injections and Exercise and mobilisation. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1474332 Wed, 28 May 2008 04:00:00 +0100 1474332 http://www.medworm.com/index.php?rid=1462954&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Forh%2F1302%2F1302.jsp%3Frss%3Dtrue New option added for Extraction of impacted wisdom teeth: different surgical methods. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1462954 Fri, 23 May 2008 04:00:00 +0100 1462954 http://www.medworm.com/index.php?rid=1462955&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0324%2F0324.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Anticonvulsants (intermittent). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1462955 Thu, 22 May 2008 04:00:00 +0100 1462955 http://www.medworm.com/index.php?rid=1462956&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fnud%2F1213%2F1213.jsp%3Frss%3Dtrue New condition. New options added for Endovascular coiling v surgical clipping, Early surgery versus late surgery, Nimodipine (oral) and Nimodipine (intravenous). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1462956 Tue, 20 May 2008 04:00:00 +0100 1462956 http://www.medworm.com/index.php?rid=1457409&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0311%2F0311.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1457409 Mon, 19 May 2008 04:00:00 +0100 1457409 http://www.medworm.com/index.php?rid=1422223&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0210%2F0210.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1422223 Fri, 02 May 2008 04:00:00 +0100 1422223 http://www.medworm.com/index.php?rid=1415919&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fcvd%2F0217%2F0217.jsp%3Frss%3Dtrue New search performed and critically appraised; no new evidence selected for inclusion. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1415919 Wed, 30 Apr 2008 04:00:00 +0100 1415919 http://www.medworm.com/index.php?rid=3161334&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fclinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fchd%2F0322%2F0322.jsp%3Frss%3Dtrue New option(s) added for: Music therapy: New option for which we found no studies. Categorised as Unknown effectiveness. Cognitive behavioural therapy: New option for which we found no studies. Categorised as Unknown effectiveness. Facilitated communication: New option for which we found no studies. Categorised as Unknown effectiveness. Melatonin: New option for which we found no studies. Categorised as Unknown effectiveness. Olanzapine: New option for which we found no studies. Categorised as Unknown effectiveness. New evidence; conclusion confirmed for: Early intensive behavioural interventions: One systematic review added comparing early intensive behav... Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=3161334 Mon, 28 Apr 2008 23:00:00 +0100 3161334 http://www.medworm.com/index.php?rid=1393424&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fskd%2F1717%2F1717.jsp%3Frss%3Dtrue New evidence; conclusion changed for Vitamin D analogues (topical). New evidence; conclusion confirmed for Corticosteroids (topical), Immunomodulators (topical) and Immunomodulators (topical). (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1393424 Fri, 18 Apr 2008 04:00:00 +0100 1393424 http://www.medworm.com/index.php?rid=1376297&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fpac%2F1409%2F1409.jsp%3Frss%3Dtrue New evidence; conclusion confirmed for Intravenous immunoglobulin, Paternal white cell immunisation, Trophoblastic membrane infusion, Aspirin (low dose) in antiphospholipid syndrome and Aspirin (low dose) plus heparin. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1376297 Mon, 14 Apr 2008 04:00:00 +0100 1376297 http://www.medworm.com/index.php?rid=1331041&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Find%2F0906%2F0906.jsp%3Frss%3Dtrue New option added for Antiparasitic drugs in neonates. New evidence; conclusion confirmed for Antiparasitic drugs in pregnancy. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1331041 Thu, 27 Mar 2008 04:00:00 +0100 1331041 http://www.medworm.com/index.php?rid=1328595&cid=s_30442_22_f&fid=30442&url=http%3A%2F%2Fwww.clinicalevidence.bmj.com%2Fceweb%2Fconditions%2Fend%2F0611%2F0611.jsp%3Frss%3Dtrue New option added for Adding carbimazole/propylthiouracil/thiamazole to radioactive iodine. (Source: Clinical Evidence) Clinical Evidence journals http://www.medworm.com/rss/comments.php?id=1328595 Tue, 25 Mar 2008 04:00:00 +0100 1328595