MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Hemorheology and Microcirculation' source. Wed, 08 Feb 2012 17:42:00 +0100 http://www.medworm.com/index.php?rid=5626566&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22258455%26dopt%3DAbstract Authors: Vayá A, Fuente JM, Montero M, Perez R, Ricart JM Abstract HIV-infected patients are at increased cardiovascular risk. Although several studies have analyzed the hemorheological profile in these patients, studies dealing with erythrocyte deformability are scarce. Moreover, studies have been performed in HIV patients on antiretroviral treatment which may influence this rheological parameter. We analyzed erythrocyte deformability (Elongation Index) at 12, 30 and 60 Pa by means of the Rheodyn SSD in 34 naïve HIV-infected patients (22 males and 12 females) and 34 HIV negative control subjects (24 males and 10 females). Erythrocyte indices (MCV, MCH, MCHC), reticulocytes, plasma lipids, iron, folic acid, vitamin B12 and hepatic enzymes were also determined. When compared with ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5626566 Wed, 18 Jan 2012 05:00:00 +0100 5626566 http://www.medworm.com/index.php?rid=5607173&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240347%26dopt%3DAbstract Authors: Presti RL, Caracciolo C, Montana M, Barone R, Catania A, Caimi G Abstract We evaluated the erythrocyte deformability in a group of subjects with polycythemia vera (PV) using a Rheodyn-SSD Laser Diffractometer, at the shear stresses of 6, 12, 30 and 60 Pa. Our data showed a significant decrease of red cell deformability, expressed as elongation index (EI), in PV subjects compared with normal controls. These results suggest that the hyperviscosity syndrome accompanying this myeloproliferative disease may be considered a mixed form, resulting from the association of a polycythemic condition with a sclerocythemic disorder. PMID: 22240347 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607173 Tue, 03 Jan 2012 05:00:00 +0100 5607173 http://www.medworm.com/index.php?rid=5607172&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240348%26dopt%3DAbstract Authors: Caimi G, Mulè G, Hopps E, Carollo C, Presti RL PMID: 22240348 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607172 Tue, 03 Jan 2012 05:00:00 +0100 5607172 http://www.medworm.com/index.php?rid=5607171&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240349%26dopt%3DAbstract Conclusion: ICG angiography is a promising diagnostic tool to quantify tissue perfusion and demonstrate critical limb ischemia and collateralization in lower extremities affected by PAD. PMID: 22240349 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607171 Tue, 03 Jan 2012 05:00:00 +0100 5607171 http://www.medworm.com/index.php?rid=5607170&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240350%26dopt%3DAbstract This study was designed to investigate whether the red cell aggregation depends on its initial level under drug therapy or cell incubation with bioactive chemical compounds. Sixty six subjects were enrolled onto this study, and sub-divided into two groups: the first group of patients (n = 36) with cerebral atherosclerosis received pentoxifylline therapy (400 mg, thrice daily) for 4 weeks. The patients of the second group were initially treated with Epoetin beta 10,000 units subcutaneously thrice a week, for 4 weeks. The second group - adult anemic patients (n = 30) with the confirmed diagnosis of solid cancer (Hb < 100 g/L). After 4 weeks of pentoxifylline treatment the red cell aggregation increased (p < 0.05) in the patients with initially low RBCA. On the other hand in the patient... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607170 Tue, 03 Jan 2012 05:00:00 +0100 5607170 http://www.medworm.com/index.php?rid=5607169&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240351%26dopt%3DAbstract Conclusions: Ischaemic postconditioning proved to be an effective defense against IR in NF groups, but it was ineffective in CF groups in kidney tissue. PMID: 22240351 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607169 Tue, 03 Jan 2012 05:00:00 +0100 5607169 http://www.medworm.com/index.php?rid=5607168&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240352%26dopt%3DAbstract This study supports the concept that RBC hyperaggregability is the prominent hemorheologic symptom of insulin resistance. PMID: 22240352 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607168 Tue, 03 Jan 2012 05:00:00 +0100 5607168 http://www.medworm.com/index.php?rid=5607167&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240353%26dopt%3DAbstract Authors: Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, Fulop A, Battyany I, Sumegi B, Toth K, Szabados E Abstract Several beneficial effects of resveratrol (RES), a natural antioxidant present in red wine have already been described. The aim of our study was to investigate if RES had a clinically measurable cardioprotective effect in patients after myocardial infarction. In this double-blind, placebo controlled trial 40 post-infarction Caucasian patients were randomized into two groups. One group received 10 mg RES capsule daily for 3 months. Systolic and diastolic left ventricular function, flow-mediated vasodilation (FMD), several laboratory and hemorheological parameters were measured before and after the treatment. Left ventricular ejection fraction showed an increasing tende... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607167 Tue, 03 Jan 2012 05:00:00 +0100 5607167 http://www.medworm.com/index.php?rid=5607166&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240354%26dopt%3DAbstract This study confirms that red cell aggregability is associated with insulin resistance and hyperinsulinemia, but plasma viscosity seems to be more related to overall glucose tolerance than to either SI or insulinemia. PMID: 22240354 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607166 Tue, 03 Jan 2012 05:00:00 +0100 5607166 http://www.medworm.com/index.php?rid=5607165&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240355%26dopt%3DAbstract Authors: Vayá A, Suescun M, Solá E, Romagnoli M, Hernández-Mijares A PMID: 22240355 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607165 Tue, 03 Jan 2012 05:00:00 +0100 5607165 http://www.medworm.com/index.php?rid=5607164&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240356%26dopt%3DAbstract Authors: Vaya A, Hernández JL, Zorio E, Bautista D Abstract In patients with acute myocardial infarction (AMI), high red blood cell distribution width (RDW) seems to predict further cardiovascular events, although the mechanism and its possible relation with anaemia and inflammation remains uncertain. We determined in 119 AMI patients before hospital discharge RDW, along with haemoglobin, haematimetric indices and inflammatory parameters (fibrinogen, C-reactive protein, plasma viscosity, neutrophil count). In the follow-up period (21 ± 11 months), 30 patients (25%) developed a recurrent cardiovascular event. In the lineal regression analysis, MCH and neutrophil count were independent determinants for RDW (beta coefficient = -0.544 p < 0.001; beta coefficient: 0.279 p = 0.001, ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607164 Tue, 03 Jan 2012 05:00:00 +0100 5607164 http://www.medworm.com/index.php?rid=5607163&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240357%26dopt%3DAbstract Authors: de Almeida JP, Freitas-Santos T, Saldanha C Abstract Recent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the erythrocyte deformability was determined. Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be independent of the degree of band 3 phosphorylation. Higher levels of nitrite, nitrate and GSNO were documented (p < 0.05). Howev... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607163 Tue, 03 Jan 2012 05:00:00 +0100 5607163 http://www.medworm.com/index.php?rid=5607162&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240358%26dopt%3DAbstract Authors: Nemeth N, Kiss F, Hever T, Brath E, Sajtos E, Furka I, Miko I Abstract It is known that hemorheological parameters show gender differences that might be altered by gonadectomy (GoE). Since micro-rheological parameters (erythrocyte deformability and aggregation) sensitively change during and after ischemia-reperfusion (I/R), the question arises whether the hemorheological effects of I/R may show gender differences and further changes might be expected when GoE and I/R are additive. Sprague-Dawley rats were divided into six groups: Control males and females, I/R males and females with 1-hour hind limb ischemia, GoE + I//R males and females when 3 months after bilateral gonadectomy the I/R was induced. Before and just after ischemia, and on the 1st-3rd-5th-7th postoperative d... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607162 Tue, 03 Jan 2012 05:00:00 +0100 5607162 http://www.medworm.com/index.php?rid=5607161&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240359%26dopt%3DAbstract In this study, we describe changes in the levels of rheological efficacy indicators after rheohaemapheresis and their clinical significance in the dry form of age-related macular degeneration (AMD). Seventy-two patients with AMD were randomised; 34 controls, and 38 patients were treated with rheohaemapheresis (separator Cobe Spectra + Evaflux filter). After the procedures, α2-macroglobulin levels decreased by approximately 58%, fibrinogen by approximately 65%, IgM by approximately 67%, LDL cholesterol by approximately 71%, apolipoprotein B by approximately 65%, and lipoprotein (a) by approximately 42%. These decreases correspond with a decrease in blood and plasma viscosity (14/12%), clinical improvement (arrest of disease progression, even visual improvement in some cases), and heretofor... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607161 Tue, 03 Jan 2012 05:00:00 +0100 5607161 http://www.medworm.com/index.php?rid=5607160&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240360%26dopt%3DAbstract In conclusion, we failed to show any consistent gradient of EPCs across ischemic limbs in relation to severity of atherosclerosis obliterans, but we speculatively suggest that a bidirectional traffic of EPCs in and out the ischemic tissue might be regulated by VEGF and SDF-1. PMID: 22240360 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607160 Tue, 03 Jan 2012 05:00:00 +0100 5607160 http://www.medworm.com/index.php?rid=5607159&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240361%26dopt%3DAbstract Authors: Nemeth N, Kiss F, Magyar Z, Miszti-Blasius K, Furka I Abstract Growing number of clinical and experimental data reflect to the gender differences of hemorheological parameters. However, little is known about the potential hemorheological effect of gonadectomy and consequent changes in sex hormone concentration. Adult, same-aged male and female rats were involved in the study. In control male and female group no surgical intervention was performed. In gonadectomized (GoE) male and female groups bilateral orchidectomy or ovariectomy were completed. Body weight measurement and blood sampling were carried out in the 1st, 2nd and 3rd postoperative months. The GoE females had significant bodyweight augmentation and their plasma estrogen concentration decreased by 40-45% by the 1... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607159 Tue, 03 Jan 2012 05:00:00 +0100 5607159 http://www.medworm.com/index.php?rid=5607158&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240362%26dopt%3DAbstract This study intended to examine the effect of 3,4-dihydroxyphenyl lactic acid (DLA), a major ingredient of Salvia miltiorrhiza, on lipopolysaccahride (LPS) -induced mouse cerebral cortical microcirculatory disturbance. Velocity of red blood cells in, and albumin leakage from venules, and the numbers of leukocytes rolling on, and adherent to the venular wall were determined by an up-right microscope after LPS (5 mg/kg/h) infusion with or without administration of DLA (5 mg/kg/h). Expression of adhesion molecules CD11b/CD18 and L-selectin on neutrophils, plasma concentration of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were evaluated by flow cytometry. Concentration of TNF-α in supernatants of LPS-stimulated mononuclear cells was evaluated in vitro by flow cytometry as well.... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607158 Tue, 03 Jan 2012 05:00:00 +0100 5607158 http://www.medworm.com/index.php?rid=5607157&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240363%26dopt%3DAbstract Authors: Nam JH, Xue S, Lim H, Shin S Abstract In vivo red blood cell aggregation will vary under pulsatile flow but few studies have been reported due to various difficulties in generating physiological flow conditions and detecting RBC aggregation. The present study developed a microfluidic system that generates cyclic pulsatile flow through a microchannel. Backscattered light signals from human blood were recorded over time and analyzed for RBC aggregation in pulsatile flow. Four different blood samples (control, normal RBCs in PBS, hardened RBCs in autologous plasma, and hardened RBCs in PBS) were examined. In a cyclic pulsatile flow condition, light intensity-time curve for the control and hardened RBCs in plasma exhibited apparent critical shear stresses that were similar to ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607157 Tue, 03 Jan 2012 05:00:00 +0100 5607157 http://www.medworm.com/index.php?rid=5607156&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240364%26dopt%3DAbstract Authors: Sandhagen B, Lind L Abstract It has previously been shown that a high hemoglobin value, a major determinant of whole blood viscosity (WBV), predicts cardiovascular events. One putative mechanism might be an impaired endothelial function. Erythrocyte deformability is another rheologic feature of the erythrocyte being of importance for the flow properties of the blood, especially in the capillaries. The present study evaluates the relationships between blood viscosity, erythrocyte deformability assessed as erythrocyte fluidity (EF), coronary risk and endothelial vasodilatory function. In the population-based PIVUS study (1016 subjects aged 70); endothelium-dependent vasodilation (EDV) was evaluated by the invasive forearm technique with acetylcholine given in the brachial ar... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607156 Tue, 03 Jan 2012 05:00:00 +0100 5607156 http://www.medworm.com/index.php?rid=5607155&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240365%26dopt%3DAbstract Conclusion: These findings show that SBP, in healthy subjects, is not influenced by haematocrit and blood viscosity. In contrast, DBP is related to the values of haematocrit. Among classical cardiovascular risk factors, waist/hip ratio is closely related to blood viscosity. PMID: 22240365 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607155 Tue, 03 Jan 2012 05:00:00 +0100 5607155 http://www.medworm.com/index.php?rid=5607154&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240366%26dopt%3DAbstract Authors: Vendégh Z, Melly A, Tóth B, Wolf K, Farkas T, Kádas I, Hamar J Abstract The developing callus requires sufficient oxygen and substrate supply. Despite the importance of these processes, we have limited understanding of regulation of the callus microcirculation. We aimed to assess the role of vasoactive substances in the microcirculation of the callus in a gap osteotomy model in the rabbit detected by laser-Doppler flowmetry. The reactions were elicited with locally applied vasoactive substances: epinephrine (E), calcitonine-gene related protein (CGRP), substance P (SP), sodium nitroprusside (SNP) and Ebrantil (Ebr) on the 10th and 15th postoperative days. Changes of the circulatory parameters were compared to changes in the ipsilateral femoral bone marrow. Perfusion pre... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607154 Tue, 03 Jan 2012 05:00:00 +0100 5607154 http://www.medworm.com/index.php?rid=5607153&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240367%26dopt%3DAbstract This study investigated changes incurred in cutaneous skin blood flux (SKBF) in the superficial veins of the lower limb by upper limb exercise training in the form of arm-cranking in 14 healthy participants over the age of 50 years. Changes in cutaneous microvascular function of the lower leg were assessed using laser Doppler Flowmetry (LDF) during a 30-minute exercise session undertaken over 4-exercise periods. Both SKBF and Time to reach Peak Perfusion (Tmax) were improved significantly during the 2nd (e.g. 121 (± 107.2) vs 280 (± 269.1) and 171 (± 34.4) vs. 247 (± 38.3) respectively) when compared to the first exercise period, while values approaching initial levels in the following stages. The results indicate that the thermoregulatory and vasodilation mechanisms observed during ex... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607153 Tue, 03 Jan 2012 05:00:00 +0100 5607153 http://www.medworm.com/index.php?rid=5607152&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240368%26dopt%3DAbstract Authors: Vayá A, Calvo J, Alcalá C, Micó L, Todolí J, Ricart JM Abstract Systemic lupus erythematosus (SLE) is characterised by increased venous and arterial thrombotic risk. Nevertheless, how hemorheological alterations contribute to thrombotic risk remains a question of debate. We aimed to determine the rheological profile in 105 patients with SLE (24 with a thrombotic event) and 105 healthy controls. We determined blood viscosity and erythrocyte aggregation along with plasma lipids and fibrinogen. Although SLE patients showed lower blood viscosity at 230 s-1 at a native hematocrit when compared with controls (p < 0.001), differences disappeared after adjusting the hematocrit to 45% (p = 0.095). When comparing SLE patients with and without thrombotic events, no differences... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607152 Tue, 03 Jan 2012 05:00:00 +0100 5607152 http://www.medworm.com/index.php?rid=5607151&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240369%26dopt%3DAbstract Authors: Nemeth N, Miko I, Furka A, Kiss F, Furka I, Koller A, Szilasi M Abstract Acid-base equilibrium and pH of blood have important clinical consequences in numerous diseases and pathophysiological conditions. The micro-rheological parameters of blood, such as red blood cell deformability and red blood cell aggregation are influenced by several metabolic factors, and provide information regarding inflammatory, septic and tissue or organ ischemia-reperfusion processes. Despite the anticipated logical relation of the blood acid-base condition, blood gas parameters and pH to red blood cell deformability and aggregation, controversial data can be found in the literature. Furthermore, related to ischemia-reperfusion hemorheological studies little is known about this issue. In this pa... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607151 Tue, 03 Jan 2012 05:00:00 +0100 5607151 http://www.medworm.com/index.php?rid=5607150&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240370%26dopt%3DAbstract Conclusions: The prevalence of NAFLD is positively associated with hematocrit levels. Though the cause-effect relationship between NAFLD and hematocrit still needs further investigation to clarify, the elevated hematocrit in NAFLD patients may be of significance to link NAFLD and cardiovascular disease. PMID: 22240370 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607150 Tue, 03 Jan 2012 05:00:00 +0100 5607150 http://www.medworm.com/index.php?rid=5607149&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240371%26dopt%3DAbstract Authors: Connes P, Pichon A, Hardy-Dessources MD, Waltz X, Lamarre Y, Simmonds MJ, Tripette J Abstract We tested the effects of submaximal exercise on blood viscosity (ηb), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated. Nine subjects performed exercise for 15 min at 105% of the first ventilatory threshold. Mean arterial pressure (MAP) and cardiac output (Qc) were measured, allowing the determination of systemic vascular resistance (SVR). Blood was sampled at rest and at the end of exercise. The ηb was determined at high shear rate and was used to calculate systemic vascular hindrance (VH). NO production was estimated by measuring plasma concentrations of NO stable end products ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607149 Tue, 03 Jan 2012 05:00:00 +0100 5607149 http://www.medworm.com/index.php?rid=5607148&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240372%26dopt%3DAbstract Authors: Cheung AT, Hu BS, Wong SA, Chow J, Chan MS, To WJ, Li J, Ramanujam S, Chen PC Abstract Soft contact lenses are commonly used to improve vision acuity or in cosmetic enhancement. We hypothesize that contact lens use can cause inadvertent damage to either the conjunctival microcirculation via direct vasoocclusion when the lens physically interacts with or damages the underlying vessels, or to the bulbar conjunctiva itself when the lens rests unevenly on the surface of the bulbar conjunctiva. Computer-assisted intravital microscopy was utilized to document (via video recording) and objectively quantify (via image analysis) real-time microvascular abnormalities resulting from changes and vessel remodeling in the conjunctival microcirculation in long-term (>2 yrs) contact le... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607148 Tue, 03 Jan 2012 05:00:00 +0100 5607148 http://www.medworm.com/index.php?rid=5607147&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240373%26dopt%3DAbstract Authors: Martini R, Andreozzi GM, Tiengo C, Azzena B, Mazzoleni F Abstract A 46 years old male with a post traumatic loss of tissue localized on the anterior surface of the right thigh and knee due to a road accident, was treated with different surgical reconstructive techniques. Combined use of autologous skin graft and acellular dermal substitute Integra® allowed the satisfactory recovery of the patient who was discharged after 82 days from the trauma. To analyse the characteristics and the quality of the healing tissues we performed a videocapillaroscopy study to assess the microcirculatory pattern of the autologous skin grafted on the dermal substitute in comparison with the autologous skin grafted on granulation tissue. The videocapillaroscopy was performed in the zone skin g... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607147 Tue, 03 Jan 2012 05:00:00 +0100 5607147 http://www.medworm.com/index.php?rid=5607146&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240374%26dopt%3DAbstract Authors: Presti RL, Canino B, Montana M, Calandrino V, Caimi G Abstract The purpose of this research was to evaluate the plasma protein carbonyl groups (PC) in 81 trained subjects (TS) who practiced regular, non professional physical activity. They were divided into three groups according to the type of sport they practiced (endurance, mixed or power). On fasting venous blood we examined the PC groups employing an enzyme-linked immunosorbent assay (ELISA) kit, in which 2,4-dinitrophenyl-hydrazine reacts with the PC forming a stable hydrazone product. In the whole group of TS a significant decrease in PC was present, in comparison with sedentary controls (SC). Dividing TS into groups, we observed a decreased PC concentration in those practicing endurance and mixed sports, but not in... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607146 Tue, 03 Jan 2012 05:00:00 +0100 5607146 http://www.medworm.com/index.php?rid=5607145&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240375%26dopt%3DAbstract Authors: Rossi M, Nannipieri M, Anselmino M, Guarino D, Franzoni F, Pesce M Abstract Since recent findings suggest a relationship between reduction in adipose tissue blood flow and metabolic or vascular complications of obesity, increase in ATBF may be considered as a further goal in the treatment of obesity, besides fat mass reduction. Therefore, this preliminary study aimed at assess subcutaneous ATBF and vasomotion in morbidly obese patients (Ob-pts) and whether sustained weight loss induced by Roux-en-Y gastric bypass (RYGB) affects the same parameters. Using laser-Doppler flowmetry (LDF) and spectral Fourier analysis, subcutaneous ATBF was measured and subcutaneous ATBF oscillations (ATBF-O) were analyzed in 16 Ob-pts, before and about one year after RYGB, and in 10 lean, heal... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607145 Tue, 03 Jan 2012 05:00:00 +0100 5607145 http://www.medworm.com/index.php?rid=5607144&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240376%26dopt%3DAbstract Authors: Jia B, Wang X, Kang A, Wang X, Wen Z, Yao W, Xie L Abstract Hypercholesterolemia is one of the cardiovascular risk factors sensitive to preventive and control interventions. Here we created a hypercholesterolemia model to investigate the effect of the long term aerobic exercise (swimming) on the hemorheology of rats fed with high-fat diet. We found that the rats fed with high-fat diet developed hypercholesterolmia and hepatic steatosis and their hemorheological and coagulative properties were all impaired as compared to those of the rats fed with standard diet. But after exercise, the total cholesterol and triglyceride in the plasma were significantly decreased and the severity of hepatic steatosis were reduced. Exercise greatly improved the erythrocytes' hemorheological p... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607144 Tue, 03 Jan 2012 05:00:00 +0100 5607144 http://www.medworm.com/index.php?rid=5607143&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240377%26dopt%3DAbstract Authors: Simmonds MJ, Minahan CL, Serre KR, Gass GC, Marshall-Gradisnik SM, Haseler LJ, Sabapathy S Abstract Heart rate variability (HRV) and haemorheology adaptations to 12 wk of varied-dose treadmill walking were investigated in women aged 65-74 yr with type 2 diabetes. Subjects were randomly allocated into two groups where exercise frequency and session duration were manipulated (Group 1 : 2 × 60 min·wk-1 or Group 2 : 4 × 30 min·wk-1), but intensity and accumulated weekly duration of exercise were consistent between groups (100% gas-exchange threshold; 120 min·wk-1). Twelve weeks of exercise training significantly improved peak oxygen uptake, time to exhaustion, and gas-exchange threshold (p < 0.05), independent of exercise group. Exercise training did not significantly ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607143 Tue, 03 Jan 2012 05:00:00 +0100 5607143 http://www.medworm.com/index.php?rid=5607142&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240378%26dopt%3DAbstract Authors: Yuvraj V, Indumathy J, Singh M Abstract Erythrocyte deformability and aggregation are important parameters related to blood flow in cardiovascular system. These are generally determined by various techniques. The present work is an attempt to implement a computerized procedure based on microscopic images of erythrocytes, obtained from cigarette smokers, to calculate these and related parameters. The subjects who have been smoking for more than ten years (Group 2) are selected and the calculated parameters are compared with that of non-smoking subjects (Group 1). The shape parameters area, perimeter and form factor of erythrocytes show significant change in Group 2 compared to that of Group 1. The erythrocyte aggregation, as measured by area occupied by aggregates, shows si... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607142 Tue, 03 Jan 2012 05:00:00 +0100 5607142 http://www.medworm.com/index.php?rid=5607141&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240379%26dopt%3DAbstract This study was performed in the human acute leukaemia monocytyc cell line, THP-1, in human monocyte-derived primary macrophages and in human umbilical cord vein endothelial cells (HUVEC). In order to subject these cells to inflammatory conditions, THP-1 and macrophage were treated with lipopolysaccharide (LPS) from E.coli and HUVEC were stimulated with the tumour necrosis factor α (TNF-α). Our results showed that although AChE expression was generally up-regulated at the mRNA level under inflammatory conditions, distinct AChE protein expression profiles were surprisingly observed among the distinct cellular types studied. Altogether, these results argue for the existence of cell specific mechanisms that regulate the expression of acetylcholinesterase in inflammation. PMID: 22240379 [... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607141 Tue, 03 Jan 2012 05:00:00 +0100 5607141 http://www.medworm.com/index.php?rid=5607140&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240380%26dopt%3DAbstract Authors: de Almeida JP, Oliveira S, Saldanhaa C Abstract The erythrocytes ability of sensing the local oxygen gradient through the hemoglobin conformation, along with changes in nitric oxide mobilization and vasomotor repercussions at the microcirculation, were reviewed in detail in this article. Different approachs trying to explain the erythrocyte death were additionally documented. Also, the influence of several types of molecules (vasoactive, oxidant/reductor) on the erythrocyte roles as sensor of (i) oxygen tissue needs, (ii) blood viscosity and myogenic environment, (iii) and inflammatory conditions were mentioned in order to highlight its physiologycal function and substitute the erroneous idea of the erythrocyte being simply a hemoglobin sac content. PMID: 22240380 [Pub... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607140 Tue, 03 Jan 2012 05:00:00 +0100 5607140 http://www.medworm.com/index.php?rid=5607139&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240381%26dopt%3DAbstract This study will permit better understanding of the reactions occurring in the organism during rapid cooling in cold water, especially in regards to the hemorheological and biochemical parameters of blood. When compared to the control group, exercise performed in water at 4°C led to an increase in the elongation index (EI, from 0.30 Pa to 4.24 Pa) with no concurrent changes in erythrocyte aggregation, blood plasma viscosity, and fatty acid composition (saturated, unsaturated, saturated/unsaturated, monounsaturated, polyunsaturated polyunsaturated- n3, polyunsaturated-n6 fatty acids) of the erythrocyte membrane. In rats swimming in water at 25°C, we observed an increase in EI at shear stress from 0.30 Pa to 2.19 Pa, along with a decrease in the half-time of total aggregation when compared ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607139 Tue, 03 Jan 2012 05:00:00 +0100 5607139 http://www.medworm.com/index.php?rid=5607138&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240382%26dopt%3DAbstract Authors: Lamarre Y, Petres S, Hardy-Dessources MD, Sinnapah S, Romana M, Laurance S, Lemonne N, Gysin J, Connes P Abstract Pregnancy in sickle cell disease (SCD) has been associated with increased complications such as vaso-occlusive crises, severe anemia and foetal loss. It has been proposed that the sickling of red blood cells (RBCs) inside the placenta circulation could participate to these complications. The present study investigated the adhesion of sickle RBCs on human trophoblast-derived cell and its extracellular matrix. Results demonstrated 1) similar adhesion of sickle RBCs and healthy RBCs to trophoblast but 2) a greater adhesion of sickle RBCs to the extracellular matrix of trophoblasts as compared with healthy RBCs. This greater adhesion could partly involve the Lu/BCA... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607138 Tue, 03 Jan 2012 05:00:00 +0100 5607138 http://www.medworm.com/index.php?rid=5607137&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240383%26dopt%3DAbstract Authors: Li YC, Liu YY, Hu BH, Chang X, Fan JY, Sun K, Wei XH, Pan CS, Huang P, Chen YY, Wang CS, Zheng J, Han JY Abstract QiShenYiQi Pills® (QSYQ) is a compound Chinese medicine used for treatment of cardiovascular diseases. However, the potential of QSYQ to inhibit cardiac fibrosis in left ventricle hypertrophy is not explored to date. We investigated the effects of post-treatment QSYQ on rat myocardial fibrosis in left ventricle hypertrophy induced by pressure over-load through ascending aortic stenosis. QSYQ was administrated 4 weeks after the surgery, at a dose of 0.8 g/kg/day over the next 4 weeks, while echocardiography was performed 4 and 8 weeks, respectively, after the surgery. Eight weeks after the surgery, myocardial blood flow was determined by Laser-Doppler Perfusion... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607137 Tue, 03 Jan 2012 05:00:00 +0100 5607137 http://www.medworm.com/index.php?rid=5607136&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240384%26dopt%3DAbstract This study tested the hypothesis that trained sickle cell trait (SCT) carriers are not subjected to greater risk of rhabdomyolysis or renal failure in response to moderate submaximal exercise than subjects with normal hemoglobin (CONT). Blood markers in 11 trained SCT carriers and 12 control counterparts were measured before and after 40 min of exercise at 55% of peak power output (Ppeak) conducted in thermoneutral environment. Body weights decreased with exercise in the same proportion in the two groups (from 65.1 ± 7.0 kg to 64.1 ± 7.0 kg and from 70.2 ± 6.6 to 68.6 ± 6.6 kg at the end of exercise in SCT and CONT, respectively). Heart rate and rectal temperature increased in the two groups in response to exercise, but the groups remained closely matched. Serum urea, CRP, CK and LDH w... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607136 Tue, 03 Jan 2012 05:00:00 +0100 5607136 http://www.medworm.com/index.php?rid=5607135&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240385%26dopt%3DAbstract Authors: Ko JY, Lim HJ, Nam JH, Shin S Abstract Recent electrical investigation of hemorheology provided useful information on the kinetics of red blood cell (RBC) aggregation. However, because of the inconsistent results in the electrical measurements, we need to understand the electrical characteristics of RBC aggregation at various flow conditions. In the present study, AC electrical-capacitance (EC) and -impedance (EI) and light backscattering (LB) were simultaneously measured for transient shear-decreasing blood flow in a microchannel. EI, EC and LB signals of RBCs in plasma show similar time-varying curves, both yielding either a peak or a minimal point in the optimal frequency range (10~500 kHz). Critical shear stress (CSS) determined from EC showed the nearly same results a... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607135 Tue, 03 Jan 2012 05:00:00 +0100 5607135 http://www.medworm.com/index.php?rid=5607174&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22240346%26dopt%3DAbstract In conclusion, intravenous anesthetics affect the hepatosplanchnic microcirculation differentially, propofol has shown protective effect on the liver and intestinal microcirculation. PMID: 22240346 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5607174 Fri, 16 Dec 2011 05:00:00 +0100 5607174 http://www.medworm.com/index.php?rid=5568499&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214671%26dopt%3DAbstract Authors: PMID: 22214671 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568499 Sat, 01 Jan 2011 05:00:00 +0100 5568499 http://www.medworm.com/index.php?rid=5568498&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214672%26dopt%3DAbstract Authors: Antonova N PMID: 22214672 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568498 Sat, 01 Jan 2011 05:00:00 +0100 5568498 http://www.medworm.com/index.php?rid=5568497&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214673%26dopt%3DAbstract Authors: Jung F PMID: 22214673 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568497 Sat, 01 Jan 2011 05:00:00 +0100 5568497 http://www.medworm.com/index.php?rid=5568496&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214674%26dopt%3DAbstract Authors: Reinhart WH PMID: 22214674 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568496 Sat, 01 Jan 2011 05:00:00 +0100 5568496 http://www.medworm.com/index.php?rid=5568495&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214675%26dopt%3DAbstract Authors: Vázquez BY, Cabrales P, Tsai AG, Intaglietta M Abstract Increasing blood and plasma viscosity is generally associated with pathological conditions, and increased cardiovascular risk, a perception based in part on studies where blood viscosity is increased to extreme values attained by hemoconcentration. Present studies, supported by epidemiological studies in humans, show that moderate increases in Hct improve cardiovascular function and vice versa. This result is due to the nonlinear regulation of peripheral vascular resistance arising from the increased production of nitric oxide following the increase of shear stress on the vascular wall due to increasing blood viscosity. Similar effects are found in when plasma viscosity is increased in the extremely hemodiluted circu... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568495 Sat, 01 Jan 2011 05:00:00 +0100 5568495 http://www.medworm.com/index.php?rid=5568494&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214676%26dopt%3DAbstract Authors: Gori T PMID: 22214676 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568494 Sat, 01 Jan 2011 05:00:00 +0100 5568494 http://www.medworm.com/index.php?rid=5568493&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214677%26dopt%3DAbstract Conclusion: CEUS does allow a reliable and immediate assessment of therapeutic efficacy of percutaneous RFA procedures of malignant liver lesions, through the continuous dynamic evaluation of tumour microcirculation. PMID: 22214677 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568493 Sat, 01 Jan 2011 05:00:00 +0100 5568493 http://www.medworm.com/index.php?rid=5568492&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214678%26dopt%3DAbstract Conclusion: Quantification of the reduction of microvascularization using TIC analysis may be a valuable periinterventional tool during DEB-TACE. Intraprocedural CEUS with i.a. and i.v. ultrasound contrast agent injection may help finding extrahepatic tumor-feeding arteries. PMID: 22214678 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568492 Sat, 01 Jan 2011 05:00:00 +0100 5568492 http://www.medworm.com/index.php?rid=5568491&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214679%26dopt%3DAbstract Conclusion: Image fusion with volume navigation (VNav) of CEUS with ceCT or ceMRI frequently allows a definite localization and diagnosis of hepatic lesions in patients with primary hepatic carcinoma or metastatic diseases. This might cause a change of the therapeutic strategy in many patients with hepatic lesions. PMID: 22214679 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568491 Sat, 01 Jan 2011 05:00:00 +0100 5568491 http://www.medworm.com/index.php?rid=5568490&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214680%26dopt%3DAbstract Conclusions: CEUS represents a highly sensitive diagnostic modality for localization of pathologic parathyroid glands in patients with pHPT. Nevertheless, it can only be recommended as first-line diagnostic procedure in specialized clinical centers with experienced investigators. PMID: 22214680 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568490 Sat, 01 Jan 2011 05:00:00 +0100 5568490 http://www.medworm.com/index.php?rid=5568489&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214681%26dopt%3DAbstract Conclusion: In comparison to conventional ultrasound and CTA the use of CEUS improved the visualization and classification of endoleaks. CEUS shows even small blood flow which can be depicted due to the real time imaging of endoleaks. In unclear cases additional ultrasound image fusion with CEUS and CT angiography improves the visualisation of small endoleaks and this may cause a change in the follow-up interval. CEUS is a good alternative to CT in the detection and follow-up of endoleaks, especially in patients with contraindications to CT contrast agents due to allergies or renal failure, enabling reduced additional costs and exposure to radiation. PMID: 22214681 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568489 Sat, 01 Jan 2011 05:00:00 +0100 5568489 http://www.medworm.com/index.php?rid=5568488&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214682%26dopt%3DAbstract Conclusion: ARFI elastometry proved to be feasible in the assessment of testicular stiffness. Older age and lower testicular volumes were associated with increased parenchymal stiffness. Further studies with more subjects may be required to define the normal range of values for each age group. PMID: 22214682 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568488 Sat, 01 Jan 2011 05:00:00 +0100 5568488 http://www.medworm.com/index.php?rid=5568487&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214683%26dopt%3DAbstract Conclusion: Fluoride-PET/CT is a valuable tool to make an indirect statement about the perfusion of the transplanted bone and was used as control in this study. CEUS is a new and promising method for the evaluation of microcirculation of buried free microvascular bone grafts and the osseous part of osseocutaneous flaps and may be used for a steady monitoring in the first postoperative days. PMID: 22214683 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568487 Sat, 01 Jan 2011 05:00:00 +0100 5568487 http://www.medworm.com/index.php?rid=5568486&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214684%26dopt%3DAbstract We examined 23 patients presenting with the abdominal symptoms mentioned above, of whom 20 had received an allo-SCT in their history and were thus potential candidates for enteric GvHD. The other three patients were included because they also presented with abdominal symptoms similar to those of GvHD, which could be ruled out due to their history. We wanted to evaluate CEUS in these patients as an additional subgroup to gain more data on the value of CEUS in early detection of enteral GvHD and in the differentiation of GvHD against other causes of abdominal discomfort. All patients underwent CEUS with particular attention to penetration of the intravenously applied microbubbles in the bowel lumen. In the patients having allo-SCT in their history we strove to achieve histological confirmati... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568486 Sat, 01 Jan 2011 05:00:00 +0100 5568486 http://www.medworm.com/index.php?rid=5568484&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214685%26dopt%3DAbstract Authors: Greis C Abstract Ultrasound contrast agents consist of tiny gas-filled microbubbles the size of red blood cells. Due to their size distribution, they are purely intravascular tracers which do not extravasate into the interstitial fluid, and thus they are perfect agents for imaging blood distribution and flow. Using ultrasound scanners with contrast-specific software, the specific microbubble-derived echo signals can be separated from tissue signals in realtime, allowing selective imaging of the contrast agent. The signal intensity obtained lies in a linear relationship to the amount of microbubbles in the target organ, which allows easy and reliable assessment of relative blood volume. Imaging of the contrast wash-in and wash-out after bolus injection, or more precisely us... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568484 Sat, 01 Jan 2011 05:00:00 +0100 5568484 http://www.medworm.com/index.php?rid=5568478&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214686%26dopt%3DAbstract Authors: Connes P, Machado R, Hue O, Reid H Abstract Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood disorder caused by single nucleotide substitution in the β-globin gene that renders their hemoglobin (HbS) much less soluble than normal hemoglobin (HbA) when deoxygenated. The polymerization of HbS upon deoxygenation is the basic pathophysiologic event leading to RBC sickling, hemolysis, vasoocclusion and ultimately to chronic organ damage. The metabolic changes imposed by exercise may initiate sickling and vaso-occlusive episodes. Further, in patients with SCA, exercise limitation may be related to anemia or chronic complications such as pulmonary vascular disease, congestive heart failure and chronic parenchymal lung disease. Few studies have ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568478 Sat, 01 Jan 2011 05:00:00 +0100 5568478 http://www.medworm.com/index.php?rid=5568472&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214687%26dopt%3DAbstract Authors: Ahmadizad S, Moradi A, Nikookheslat S, Ebrahimi H, Rahbaran A, Connes P Abstract The purpose of this investigation was to examine the effects of age on the acute responses of hemorheological variables and biochemical parameters to a single bout of sub-maximal endurance exercise. Fifteen young (20-30 years), 15 middle-aged (40-50 years) and 12 old (60-70 years) male subjects participated in the study. All subjects performed one single bout of endurance exercise encompassed 30-min cycling at 70-75% of maximal heart rate which was followed by 30-min recovery. Three blood samples were taken before, immediately after exercise and after 30-min recovery. Resting levels of hematocrit, red blood cells count, plasma albumin and fibrinogen concentrations, plasma viscosity and whole b... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568472 Sat, 01 Jan 2011 05:00:00 +0100 5568472 http://www.medworm.com/index.php?rid=5568466&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214688%26dopt%3DAbstract Authors: Baskurt OK, Ulker P, Meiselman HJ Abstract Nitric oxide (NO) is accepted to be an important factor affecting the degree of vascular tone in various portions of the circulation. Until recently, research in this area has focused on endothelial cells as a NO source, and there is general agreement that: 1) the level of wall shear stress is the primary determinant of endothelial nitric oxide synthase (eNOS) expression; 2) exercise training induces changes of endothelial cell NO synthesizing activity; 3) phosphorylation patterns of eNOS are altered following exercise episodes. However, there is now a growing body of evidence for the existence of similar nitric oxide synthesizing mechanisms in human red blood cells (RBC). Erythrocyte NOS activity has been demonstrated to be induc... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568466 Sat, 01 Jan 2011 05:00:00 +0100 5568466 http://www.medworm.com/index.php?rid=5568462&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214689%26dopt%3DAbstract Authors: Brun JF, Varlet-Marie E, Romain AJ, Raynaud de Mauverger E Abstract It is well known that body composition influences blood rheology (higher blood viscosity and RBC aggregation in obese individuals). On the other hand, blood rheology is related to exercise performance (the fitter the athlete the more fluid the blood). The 'paradox of hematocrit' is that most of the time trained athletes have a lower hematocrit while doping aims at increasing it, a situation which seems to challenge physiology and can be explained by the fact that systemic hematocrit may have poor physiological relevance at the microcirculatory level in exercising muscles. However, recent studies dealing with the marked differences among hemorheologic profiles observed in selected sports lead to the concept... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568462 Sat, 01 Jan 2011 05:00:00 +0100 5568462 http://www.medworm.com/index.php?rid=5568461&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214690%26dopt%3DAbstract Authors: Romain AJ, Brun JF, Varlet-Marie E, Raynaud de Mauverger E Abstract Regular exercise has been reported to improve blood rheology, but all the studies investigating this issue included a reduced number of subjects, and thus it was logic to perform a meta-analysis of them in order to better characterize this physiological effect. Research was handed on Medline from 1950 to 2010. Studies were selected if they were in English and if they had one or several of these following outcomes: lactate, blood viscosity, RBC rigidity, hematocrit (%), RBC aggregation, fibrinogen and plasma viscosity. They were also kept if they included exercise in their protocol. Results were computed with the fixed effect model and the weighting method was the inverse variance. 11 studies with 175 peopl... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568461 Sat, 01 Jan 2011 05:00:00 +0100 5568461 http://www.medworm.com/index.php?rid=5568459&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214691%26dopt%3DAbstract Authors: Brun JF, Varlet-Marie E, Cassan D, Raynaud de Mauverger E Abstract Athletes involved in rugby are characterized by a very specific pattern of body composition with an unusually important muscle mass. In a preceding study about rugbymen we evidenced that they exhibit a correlation between red blood cell aggregability and the amount of body fat although it remains within a normal range, and that red cell rigidity was correlated to isometric adductor strength. We had the opportunity of studying the relationships among exercise performance, body composition and hemorheology in 19 female rugby players (age 19-26, mean: 24.47 ± 0.67 yr) practising 4 - 10 hr/wk (mean 7.15 ± 0.3) since 1-12 yr (mean 4,05 ± 0,694). VO2max was not related by its own to blood rheology, either hema... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568459 Sat, 01 Jan 2011 05:00:00 +0100 5568459 http://www.medworm.com/index.php?rid=5568458&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214692%26dopt%3DAbstract Authors: Brun JF, Varlet-Marie E, Fédou C, Raynaud de Mauverger E Abstract Aerobic capacity and performance are associated with increased blood fluidity, while sedentarity leads to decreased exercise performance, and blood hyperviscosity. We aimed at investigating the relationships among body composition, blood rheology and exercise performance in this situation. In 46 sedentary subjects (53.09 ± 1.79 yr old; BMI = 32,35 ± 0,80) attending our unit for an exercise prescription we performed an exercise test to assess aerobic capacity, together with blood lipid profile and blood viscosity (MT 90 viscometer, Myrenne erythroaggregometer). The maximal aerobic capacity VO2max was not correlated to blood rheology but its changes were negatively correlated to those of plasma viscosity (r... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568458 Sat, 01 Jan 2011 05:00:00 +0100 5568458 http://www.medworm.com/index.php?rid=5568457&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214693%26dopt%3DAbstract Authors: Varlet-Marie E, Brun JF, Fédou C, Raynaud de Mauverger E Abstract The aim of this study was to assess on a large series of soccer players our previous reports on blood rheology and exercise performance. In 99 soccer players (Age 24,17 ± 0,42 yr; weight 75,87 ± 0,89 kg; VO2max 46,86 ± 0,95 mL/min/kg) an exercise test was performed for measuring maximal aerobic capacity and we measured blood viscosity at high shear rate (MT90 viscometer) and RBC aggregation (Myrenne MK1). The French questionnaire developped by the consensus group on overtraining of the French Society of Sports Medicine (SFMS) was also employed. The only hemorheologic statistical determinant of VO2max was hematocrit (Hct r = -0.2439; p = 0.0303). The lactate threshold 2 mmol/l was negatively correlated to... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568457 Sat, 01 Jan 2011 05:00:00 +0100 5568457 http://www.medworm.com/index.php?rid=5568454&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214694%26dopt%3DAbstract Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise. PMID: 22214694 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568454 Sat, 01 Jan 2011 05:00:00 +0100 5568454 http://www.medworm.com/index.php?rid=5568453&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214695%26dopt%3DAbstract Conclusion: The regulation of the cutaneous microcirculation did not follow diameter changes of the conduit artery (BA) but seems to be dominated by the precapillary arterioles. PMID: 22214695 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568453 Sat, 01 Jan 2011 05:00:00 +0100 5568453 http://www.medworm.com/index.php?rid=5568452&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214696%26dopt%3DAbstract Conclusion: For the first time we could show that hrCEUS is a reliable method to evaluate the viability of OFF. The AUC and Ttop seem to be a valuable parameter to detect the microcirculation around and inside the bone transplant. PMID: 22214696 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568452 Sat, 01 Jan 2011 05:00:00 +0100 5568452 http://www.medworm.com/index.php?rid=5568451&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214697%26dopt%3DAbstract Authors: Damaske A, Muxel S, Fasola F, Radmacher MC, Schaefer S, Jabs A, Orphal D, Wild P, Parker JD, Fineschi M, Munzel T, Forconi S, Gori T Abstract The slow coronary flow phenomenon (SCF), a condition described by the presence of inappropriate delay in the progression of intracoronary contrast during angiography in the absence of stenoses, has been shown in some patients presenting with chest pain. While several conditions leading to "secondary" slow flow are known, there are no definitive conclusions regarding the exact pathogenesis of "primary" SCF. The present paper outlines the mechanisms that may lead to SCF, emphasizing the role of hemorheological and vascular factors in the pathogenesis of this phenomenon. Small vessel dysfunction has been proposed in the pathogenesis of ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568451 Sat, 01 Jan 2011 05:00:00 +0100 5568451 http://www.medworm.com/index.php?rid=5568450&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214698%26dopt%3DAbstract Conclusions: Our findings demonstrate that transient iNOS overexpression potentially leads to a significant decrease of regional late enhancement with a positive effect on regional cardiac function in the ischemic area in a large animal model of postischemic heart failure. PMID: 22214698 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568450 Sat, 01 Jan 2011 05:00:00 +0100 5568450 http://www.medworm.com/index.php?rid=5568449&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214699%26dopt%3DAbstract Authors: Lechler P, Klein SM, Prantl L, Englert C, Renkawitz T, Grifka J Abstract Both, skeletal development and fracture healing depend on an orchestrated sequence of cellular growth and differentiation processes. Regional changes in tissue oxygen tension were proposed as key regulators of osteoblast proliferation and phenotype. Hypoxia results in the stabilization of hypoxia-inducible factor-1α (HIF-1α), thus influencing expression of a multitude of genes required for cellular adaptation. In the present study we dissected the effects of HIF-1α on cellular proliferation and gene expression of primary human osteoblasts. Primary human osteoblasts were studied by transfecting siRNA and plasmids coding for human HIF-1α. Gene expression was analyzed by western blot and quantitative... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568449 Sat, 01 Jan 2011 05:00:00 +0100 5568449 http://www.medworm.com/index.php?rid=5568448&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214700%26dopt%3DAbstract Authors: Luca MC, Liuni A, Muxel S, Münzel T, Forconi S, Gori T, Parker JD Abstract Despite decades of research and thousands of experimental publications, acute preconditioning strategies have yet to be implemented in clinical practice. While some have attributed this to a failure of the experimental studies to mimic the clinical environment, others have suggested that acute preconditioning strategies themselves may possess physiological limitations. In particular, there is evidence to suggest a reduced efficacy of acute preconditioning in the aged heard and in disease states, such as diabetes, hypertension, hyperlipidemia, and atherosclerosis. In addition, pharmacologic agent commonly used in clinical practice, such as sulfonylureas and non-steroidal anti-inflammatory agents may... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568448 Sat, 01 Jan 2011 05:00:00 +0100 5568448 http://www.medworm.com/index.php?rid=5568447&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214701%26dopt%3DAbstract Authors: Tikhomirova IA, Oslyakova AO, Mikhailova SG Abstract We estimated hemorheological parameters of vein blood samples and cutaneous microvascular blood flow in patients with acute ischemic stroke and in controls. The worsened blood rheological properties were registered in patients with stroke: the enhanced whole blood viscosity was due to the substantial increase of plasma viscosity and the impairment of microrheological blood properties: elevated erythrocyte aggregability and decreased deformability compared to the healthy group. The decrease of oxygen consumption fixed by rheological methods and by laser Doppler flowmetry led us to conclude that the tissue hypoxia took place in patients with stroke. The regulatory mechanisms aimed to maintain blood supply to tissue were ac... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568447 Sat, 01 Jan 2011 05:00:00 +0100 5568447 http://www.medworm.com/index.php?rid=5568446&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214702%26dopt%3DAbstract Conclusions: An activation or inhibition of NMDA receptors on RBCs has no influence on their deformability and aggregability. RBC aggregability varies largely among individuals, which was consistently detected by the sedimentation rate and the Myrenne aggregometer, but not by low shear viscosity, which should not be used for this purpose. PMID: 22214702 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568446 Sat, 01 Jan 2011 05:00:00 +0100 5568446 http://www.medworm.com/index.php?rid=5568445&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214703%26dopt%3DAbstract Authors: Ruef P, Ehrhard M, Frommhold D, Koch L, Fritzsching B, Poeschl J Abstract There are several reports demonstrating an involvement of bacterial toxins in the rigidity of red blood cells (RBC). The present study investigates the influence of E. coli F-583-Rd lipid A on RBC deformability under mechanical shear stress. Verapamil (Ca2+ channel inhibitor), staurosporine (protein kinase inhibitor) and Y-27632 (rho-kinase inhibitor) were used to modify the effect of lipid A on RBC deformability. We also determined if E. coli F-583-Rd Lipid A could induce an increase of intracellular Ca2+ concentration. For the deformation measurements RBC (10 adult donors) were incubated with E. coli F-583-Rd lipid A (100μg/ml) and also co-incubated with either verapamil (10-7 mol/l), staurosporin... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568445 Sat, 01 Jan 2011 05:00:00 +0100 5568445 http://www.medworm.com/index.php?rid=5568444&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214704%26dopt%3DAbstract Authors: Fornal M, Korbut RA, Grodzicki T Abstract Relationship between erythrocyte deformability and: a) soluble cell adhesion molecules concentration, b) glomerular filtration rate (eGFR) has been investigated in three study groups: a group of 20 patients with diagnosed arterial hypertension, a group of 20 individuals with exclusively hypercholesterolemia and a group of 22 healthy persons. The individuals with hypertension or hypercholesterolemia were free of any other cardiovascular disease risk factor and were not on any therapy prior to entering the study. Clinical and laboratory data included systolic and diastolic blood pressure (obtained by ABPM), lipids profile, eGFR, red blood cell (RBC) deformability (assessed by shear stress laser diffractometry) and levels of circulati... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568444 Sat, 01 Jan 2011 05:00:00 +0100 5568444 http://www.medworm.com/index.php?rid=5568443&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214705%26dopt%3DAbstract Authors: Papp J, Toth A, Sandor B, Kiss R, Rabai M, Kenyeres P, Juricskay I, Kesmarky G, Szabados S, Toth K Abstract Conditions during coronary artery bypass grafting (CABG) performed on beating heart (off-pump) are more physiological than using extracorporeal perfusion (on-pump). The present study aims to examine the hemorheological aspects of the two techniques. Blood samples were taken from patients undergoing on-pump (n = 25) and off-pump (n = 22) CABG, upon arrival to the operating theatre, after 20 and 40 minutes during the operation, after closing the thorax, on the 1st and 2nd postoperative days, and during the 2nd and 6th month control check-ups. Hematocrit (Hct), plasma and whole blood viscosity (PV, WBV; Hevimet 40 capillary viscometer), red blood cell (RBC) aggregation ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568443 Sat, 01 Jan 2011 05:00:00 +0100 5568443 http://www.medworm.com/index.php?rid=5568442&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214706%26dopt%3DAbstract This report provides an overview on some of these issues and how they can be addressed by a tailored design of novel polymer-based biomaterials. Multifunctional shape-memory polymers are highlighted as a class of materials that combine biocompatibility and the capability for stimuli-induced active movements for anchoring of implants with a controlled degradation and drug release profile to enable a functional regeneration of the tissue at the application site. PMID: 22214706 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568442 Sat, 01 Jan 2011 05:00:00 +0100 5568442 http://www.medworm.com/index.php?rid=5568441&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214707%26dopt%3DAbstract This article gives an overview of the preparation of such vascular grafts by means of tissue engineering. PMID: 22214707 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568441 Sat, 01 Jan 2011 05:00:00 +0100 5568441 http://www.medworm.com/index.php?rid=5568440&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214708%26dopt%3DAbstract Authors: Braune S, Hönow A, Mrowietz C, Cui J, Kratz K, Hellwig J, Uzüm C, Klitzing RV, Lendlein A, Jung F Abstract Small calibre vascular prostheses (<6 mm) still lack medium and long term patency. Inelasticity of the prosthesis is one of the characteristics, which is involved in the mechanisms of failure (e.g. the development of neointimal hyperplasia at the distal anastomosis). Here we report about covalently crosslinked poly(n-butyl acrylate) networks (cPnBA) with adjustable elastic moduli, which can be tailored to values of human arteries (between 100 and 1000 kPa). Motivated by the potential application of such polymer networks as cardiovascular prosthesis, adhesion, activation and thrombus formation of human platelets on cPnBA networks were evaluated. All cPnBA-samples ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568440 Sat, 01 Jan 2011 05:00:00 +0100 5568440 http://www.medworm.com/index.php?rid=5568439&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214709%26dopt%3DAbstract Authors: Dreyer L, Krolitzki B, Autschbach R, Vogt P, Welte T, Ngezahayo A, Glasmacher B Abstract Endothelial cells (ECs) are permanently exposed to the blood flow and the resulting shear stress, its magnitude varying with the EC site in the blood stream. Along with other mechanical stimuli like vessel wall stretching or hydrostatic blood pressure, this shear stress modulates the endothelial cell function, morphology and gene expression. Here, we describe our improved cone-and-plate reactor that applies up to 10 dyn/cm2 uniform wall shear stress on a defined, ring-shaped region on a culture dish. At the same time, a hydrostatic pressure of up to 195 mmHg can be applied by increasing the atmospheric pressure in the incubator box. Gas composition can be controlled additionally, used ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568439 Sat, 01 Jan 2011 05:00:00 +0100 5568439 http://www.medworm.com/index.php?rid=5568438&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214710%26dopt%3DAbstract Conclusions: Appropriate to the decrease in hemoglobin concentration and platelet count, clear alterations of serum erythropoietin and thrombopoietin levels could postoperatively be observed. EPO levels showed an inverse correlation to hemoglobin concentrations, whereas a disturbed thrombopoietin feedback mechanism resulted in the phenomenon of reactive thrombocytosis. PMID: 22214710 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568438 Sat, 01 Jan 2011 05:00:00 +0100 5568438 http://www.medworm.com/index.php?rid=5568437&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214711%26dopt%3DAbstract Authors: de Almeida JP, Freitas-Santos T, Saldanha C Abstract Recent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO) modulation. In the present pioneer in-vitro study, whole blood samples were harvested from healthy subjects and aliquots were incubated in the absence (control aliquots) and presence of fibrinogen at different degrees of band 3 phosphorylation, and the levels of NO, nitrite, nitrate and S-nitroglutathione (GSNO) were determined. Hyperfibrinogenemia interferes with erythrocyte NO mobilization without changing its efflux in a way that seems to be dependent of the degree of band 3 phosphorylation. In presence of higher fibrinogen conc... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568437 Sat, 01 Jan 2011 05:00:00 +0100 5568437 http://www.medworm.com/index.php?rid=5568436&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214712%26dopt%3DAbstract Authors: Gluhcheva Y, Ivanov I, Atanasov V, Antonova N, Ivanova J, Mitewa M Abstract The study evaluated the affect of chronic cadmium (Cd) and monensin treatment on some hematological parameters and its relationship with the rheological variables. Adult male mice were subjected to chronic treatment with cadmium acetate [Cd(CH3COO)2 × 2H2O] (group 1), Cd(CH3COO)2 × 2H2O followed by treatment with low dose monensin (group 2) and Cd(CH3COO)2 × 2H2O followed by high dose monensin treatment (group 3). Cd(CH3COO)2 × 2H2O and deprotonated monensin were dissolved in distilled water and given daily to the experimental animals. Mice drinking distilled water served as a control group (group 4). Hematological parameters and erythrocyte morphology were evaluated in parallel with whole bloo... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568436 Sat, 01 Jan 2011 05:00:00 +0100 5568436 http://www.medworm.com/index.php?rid=5568435&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214713%26dopt%3DAbstract Authors: Mayer A, Hiebl B, Lendlein A, Jung F Abstract So called intermediate (MO2) monocytes/macrophages possess anti-inflammatory properties and express the MO lineage marker CD163. On a hydrophilic, acrylamide-based hydrogel human intermediate (CD14++ CD16+) CD163++ monocytes/macrophages (aMO2) which were angiogenically stimulated, maintained a pro-angiogenic and non-inflammatory status for at least 14 days. Here we explored, whether this aMO2 subset can positively influence the proliferation of human umbilical venous endothelial cells (HUVECs) without switching back into a pro-inflammatory (MO1) phenotype. aMO2 or HUVEC were seeded alone on glass cover slips (0.5 × 105 cells / 1.33 cm2) in a HUVEC specific cell culture medium (EGM-2) for 3 hrs, 24 hrs and 72 hrs or under co-cu... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568435 Sat, 01 Jan 2011 05:00:00 +0100 5568435 http://www.medworm.com/index.php?rid=5568434&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214714%26dopt%3DAbstract This study was designed to evaluate hemorheological changes in patients with cerebrovascular disease (CVD) and peripheral arterial disease (PAD) after 4 weeks of pentoxifylline therapy as well as to study red blood cell microrheological variables after the cell incubation with pentoxifylline and some phosphodiesterase (PDE) activity inhibitors. The patients with CVD (n = 50) and PAD (n = 33) were treated with pentoxifylline (400 mg, thrice a day) for 4 weeks. Before and after drug therapy the hemorheological measurements including plasma and whole blood viscosity, red blood cell aggregation (RBCA) and deformability (RBCD) were completed. In vitro study RBCs were incubated with: 1) Vinpocetine - inhibitor PDE-1, 10 μM; 2) Rolipram - PDE-4, 10 μM; 3) Isobutyl-methylxanthine (IBMX) - nonsel... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568434 Sat, 01 Jan 2011 05:00:00 +0100 5568434 http://www.medworm.com/index.php?rid=5568433&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214715%26dopt%3DAbstract Authors: Antonova N, Riha P, Ivanov I, Gluhcheva Y Abstract Mechanical and electrical properties of the normal RBCs suspensions and of hardened after treatment with glutaraldehyde (0.01-2.5%) RBCs in isotonic physiological solution and Dextran 70 000 (Dextran 70) and Polyethylene glycol 35 000 (PEG) and adjusted to hematocrit of 40%, were evaluated. Apparent viscosity and conductivity were measured under steady and transient flow regimes at low shear rates and at different local structure of the flow at 37°C. A time course of conductivity was recorded in parallel with the rheological properties of the RBC suspensions and conductivity and apparent viscosity dependences on shear rates were studied and compared at different concentrations of Dextran 70, PEG and glutaraldehyde. Low sh... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568433 Sat, 01 Jan 2011 05:00:00 +0100 5568433 http://www.medworm.com/index.php?rid=5568432&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214716%26dopt%3DAbstract Authors: Reinhart WH, Schulzki T Abstract We studied the influence of metabolic depletion on red blood cell (RBC) aggregability, which is a determinant of blood flow. Heparinized blood was stored at room temperature for 0, 24, and 48 h. RBCs were washed twice and resuspended in Tris-buffer containing 3% dextran 70 (hematocrit 30%). Suspension viscosities were measured at 37°C and shear rates of 37.6 and 0.1 s-1, RBC aggregability was analysed by the sedimentation rate, direct microscopic visualization and a Myrenne aggregometer. RBCs in autologous plasma showed an increasing echinocytic shape transformation, which was reversible in buffer. The viscosities of RBC suspensions in buffer remained unchanged at both low (0.1 s-1) and high shear rate (37.6 s-1), the latter result indicat... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568432 Sat, 01 Jan 2011 05:00:00 +0100 5568432 http://www.medworm.com/index.php?rid=5568431&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214717%26dopt%3DAbstract Authors: Saldanha C, de Almeida JP Abstract We review the major hemorheological experimental studies that show the erythrocyte aggregation as a link between basic and clinical research. The results of the clinical cross-sectional and longitudinal studies presented here will highlight the possible association between erythrocyte aggregation and plasma fibrinogen. Basic studies conducted in vitro are also mentioned as for its relevance in answering questions raised in clinical settings, as well as and in understanding the underlying influent factors in the erythrocyte tendency to aggregate and disaggregate. PMID: 22214717 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568431 Sat, 01 Jan 2011 05:00:00 +0100 5568431 http://www.medworm.com/index.php?rid=5568424&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214718%26dopt%3DAbstract Authors: Sievers H, Bahramsoltani M, Käßmeyer S, Plendl J Abstract Human microvascular endothelial cells derived from myocardium (HCMEC), lung (HPMEC) and foreskin (HDMEC) showed different angiogenic potency when cultivated in their original growth media provided by the distributors. In order to standardize microenvironmental conditions in an all-in-one assay of angiogenesis the aim of this study was to find one optimal growth medium for the endothelial cells derived from the different organs. Therefore each endothelial cell type was cultivated under identical conditions in the different original growth media as well as in several media formulations of the original growth media. Results reveal that even if cultivated in the same growth medium under exactly the same cultivation co... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568424 Sat, 01 Jan 2011 05:00:00 +0100 5568424 http://www.medworm.com/index.php?rid=5568419&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214719%26dopt%3DAbstract Authors: Forconi S, Wild P, Munzel T, Gori T Abstract The role of viscosity, and of interindividual variations in this parameter, in the pathophysiology of cardiovascular disease remain incompletely understood. Any speculation regarding the possible impact of "hemorheological" therapies is therefore even more complex. In the last years, the debate regarding the relationship between increased viscosity and atherogenesis has been opened again. While the traditional view postulates that an increased blood viscosity has invariably a negative impact on tissue perfusion and therefore should be considered as a risk factor (when not as a true disease), a more recent hypothesis has been formulated based on the observation that small increases in viscosity actually have vasodilatory effects,... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568419 Sat, 01 Jan 2011 05:00:00 +0100 5568419 http://www.medworm.com/index.php?rid=5568418&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214720%26dopt%3DAbstract Authors: Vayá A, Hernández-Mijares A, Bonet E, Sendra R, Solá E, Pérez R, Corella D, Laiz B Abstract The contribution of hemorheological alterations in the prothrombotic condition in patients with metabolic syndrome (MS) remains a question of debate. We aimed to determine the association between MS and hemorheological parameters by means of a case-control study in 61 MS patients and 89 controls without MS. We determined blood viscosity at 230 s-1 (Brookfield DVIII viscosimeter); plasma viscosity (Fresenius capillary plasma viscosimeter); erythrocyte aggregation at stasis and 3 s-1 (MA-1 erythrocyte aggregometer); erythrocyte deformability (Rheodyn SSD at shear stresses of 12, 30 and 60 Pascals) and fibrinogen, along with anthropometric, lipidic and inflammatory parameters. MS p... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568418 Sat, 01 Jan 2011 05:00:00 +0100 5568418 http://www.medworm.com/index.php?rid=5568417&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214721%26dopt%3DAbstract Authors: Velcheva I, Damianov P, Antonova N, Stoyneva Z, Mantarova S, Dimitrova V Abstract The study aimed to investigate the hemorheological parameters in patients with diabetes mellitus type 2 and to estimate their relationship with the cerebral and cutaneous blood flow and their responses to postural changes. The basic hemorheological constituents: hematocrit (Ht), fibrinogen (Fib), whole blood (WBV) and plasma viscosity (PV) were examined in 20 patients with diabetes mellitus type 2 and in 10 healthy age and sex matched controls. Blood flow velocity in the middle cerebral artery (MCA) was measured by transcranial Doppler monitoring at rest and during 5-min head-up tilt. Also laser Doppler-recorded tiptoe skin blood flow was investigated and venoarteriolar reflex perfusion respo... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568417 Sat, 01 Jan 2011 05:00:00 +0100 5568417 http://www.medworm.com/index.php?rid=5568416&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214722%26dopt%3DAbstract Authors: Velcheva I, Damianov P, Mantarova S, Antonova N Abstract Our study aimed to investigate the relationship between hemorheological parameters and heart rate variability (HRV) in patients with diabetes mellitus type 2. Hemorheological variables, including hematocrit (Ht), fibrinogen (Fib), whole blood (WBV) and plasma viscosity (PV) at shear rates of 0.0237 s-1 to 128.5 s-1 were examined in 20 patients with diabetes mellitus type 2 and in 10 control subjects. They all underwent non-invasive short-term monitoring of heart rate at rest and after passive head-up tilt. Measurement of the R-R intervals and calculation of the time domain parameters and the power spectral data were performed by our softwear, using fast Fourier transformation. Significant increase of Fib and WBV in t... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568416 Sat, 01 Jan 2011 05:00:00 +0100 5568416 http://www.medworm.com/index.php?rid=5568415&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214723%26dopt%3DAbstract Authors: Gehmert S, Gehmert S, Bai X, Klein S, Ortmann O, Prantl L Abstract MSCs reside within their niche and pathologic conditions such as hypoxia and inflammation can lead to mobilization and migration of Mesenchymal Stem Cells (MSCs). Xenograft animal models using immundeficient mouse demonstrated that MSCs migrated to and distributed throughout the tumors and were found to engraft into tumor stroma and vasculature. In contrast, MSCs primarily incorporated within tumor-capsula and did not invade the tumor using immuncompetent tumor allograft models. Here we hypothesize that MSCs migrate primarily towards an inflammatory milieu independent of the underlying biological process causing the inflammation. Murine MSCs (mASCs) were isolated from subcutaneous fat tissues and transduced... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568415 Sat, 01 Jan 2011 05:00:00 +0100 5568415 http://www.medworm.com/index.php?rid=5568414&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214724%26dopt%3DAbstract Conclusion: As shown before in other studies, RI values andkidney size are of doubtful utility in the evaluation of kidneyallograft dysfunction. ARFI-based elasticity measurement showspromise as a complementary non-invasive parameter in follow-ondiagnosis of renal allograft rejection. PMID: 22214724 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568414 Sat, 01 Jan 2011 05:00:00 +0100 5568414 http://www.medworm.com/index.php?rid=5568413&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214725%26dopt%3DAbstract Conclusion: Assessment of renal lesions using real time 3D-US is feasible and improves the identifiability of renal lesions. PMID: 22214725 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568413 Sat, 01 Jan 2011 05:00:00 +0100 5568413 http://www.medworm.com/index.php?rid=5568412&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214726%26dopt%3DAbstract Authors: Abstract Erratum to [Clinical Hemorheology and Microcirculation 48 (1-3) (2011), 29-40] DOI 10.3233/CH-2011-1406. PMID: 22214726 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568412 Sat, 01 Jan 2011 05:00:00 +0100 5568412 http://www.medworm.com/index.php?rid=5568410&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214727%26dopt%3DAbstract Authors: PMID: 22214727 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5568410 Sat, 01 Jan 2011 05:00:00 +0100 5568410 http://www.medworm.com/index.php?rid=5347732&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012826%26dopt%3DAbstract In this study, we established an in vitro model to evaluate the influence of free radical attacks on hemorheological parameters. A well-sealed chamber with hyperbaric oxygen was used to simulate an environment of free radical attacks. Hemorheological parameters, including whole blood viscosity, erythrocyte membrane lipid peroxidation, and erythrocyte deformability, were investigated. We then used the in vitro model to evaluate the anti-free radical effects of some well-known catechin antioxidants, such as epigallocatechin gallate (EGCG), (-)-epicatechin 3-gallate (ECG), and (-)-epigallocatechin (EGC) on abnormal hemorheological parameters induced by hyperbaric oxygen. The results show that an increase in oxygen partial pressure (1.0, 1.5, 2.0 and 2.5 atm) and exposure time (4, 8, 12 and 16... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347732 Sat, 01 Jan 2011 05:00:00 +0100 5347732 http://www.medworm.com/index.php?rid=5347731&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012827%26dopt%3DAbstract Conclusions: The deformability and oxygen carrying functions of RBCs did not show a significant difference according to various components of cold blood cardioplegia during 10 minutes of incubation. PMID: 22012827 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347731 Sat, 01 Jan 2011 05:00:00 +0100 5347731 http://www.medworm.com/index.php?rid=5347730&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012828%26dopt%3DAbstract This study was designed to investigate whether the red cell aggregation depends on its initial level under drug therapy or cell incubation with bioactive chemical compounds. Sixty six subjects were enrolled onto this study, and sub-divided into two groups: the first group of patients (n = 36) with cerebral atherosclerosis received pentoxifylline therapy (400 mg, thrice daily) for 4 weeks. The patients of the second group were initially treated with Epoetin beta 10,000 units subcutaneously thrice a week, for 4 weeks. The second group - adult anemic patients (n = 30) with the confirmed diagnosis of solid cancer (Hb < 100 g/L). After 4 weeks of pentoxifylline treatment the red cell aggregation increased (p < 0.05) in the patients with initially low RBCA. On the other hand in the patient... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347730 Sat, 01 Jan 2011 05:00:00 +0100 5347730 http://www.medworm.com/index.php?rid=5347729&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012829%26dopt%3DAbstract Authors: Vayá A, Suescun M, Hernández JL, Pérez ML, Palanca S, Laiz B Abstract Although several studies have been published regarding rheological behaviour of red blood cells in beta and delta-beta thalassaemia traits, little information about erythrocyte deformability in alpha-thalassaemia carriers is available. We aimed to determine erythrocyte deformability in heterozygous (silent, -α/αα) and homozygous (minor alpha-thalassaemia, -α/-α) carriers of the alpha-thalassaemia trait for the alpha 3.7 deletion, the most common in our geographical area. We evaluated erythrocyte deformability by means of the elongation index (EI) in a Rheodyn SSD at 12, 30 and 60 Pa, along with basic haematological cell count, erythrocyte indices, reticulocytes, plasma lipids and iron metabolism ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347729 Sat, 01 Jan 2011 05:00:00 +0100 5347729 http://www.medworm.com/index.php?rid=5347728&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012830%26dopt%3DAbstract Authors: Vayá A, Hernández-Mijares A, Suescun M, Solá E, Cámara R, Romagnoli M, Bautista D, Laiz B Abstract There are few studies on haemorheological disturbances in morbidly obese patients. The role played by the metabolic syndrome on the rheological profile of morbidly obese subjects has not yet been established, and it is not clear whether morbidly obese, but "metabolically healthy", show rheological alterations. We aimed to determine the whole rheological profile in 136 morbidly obese patients and 136 normo-weight volunteers, along with plasma lipids, inflammatory and insulin resistance parameters. Patients had statistically higher glucose, triglycerides, HbA1c, leptin, insulin, HOMA, CRP, leucocytes, fibrinogen, plasma viscosity (p < 0.001, respectively), erythrocyte ag... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347728 Sat, 01 Jan 2011 05:00:00 +0100 5347728 http://www.medworm.com/index.php?rid=5347727&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012831%26dopt%3DAbstract Authors: Brun JF, Varlet-Marie E, Raynaud de Mauverger E, Mercier J Abstract While recent studies suggested that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio (WHR) in addition to body index mass (BMI) in assessing the risk of death, this issue remains cintroversial since most authors conclude that BMI explains almost all the obesity-related risk of diabetes and conary heart disease (CHD). We investigated the separate effects of BMI and WHR on blood rheology in 430 patients attending to a metabolic check-up and exhibiting all the spectrum of age (11-77 yr) and BMI (15-50 kg/m2). BMI and WHR are correlated to each other (r = 0.269; p = 0.009) and are both predictors of blood visco... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347727 Sat, 01 Jan 2011 05:00:00 +0100 5347727 http://www.medworm.com/index.php?rid=5347726&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012832%26dopt%3DAbstract Conclusions: Given that the percentage of MVA was positively correlated with tumor blood volume, washout time may be associated with HCC blood volume. PMID: 22012832 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347726 Sat, 01 Jan 2011 05:00:00 +0100 5347726 http://www.medworm.com/index.php?rid=5347723&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012833%26dopt%3DAbstract Conclusion: Postoperative sublingual MBF is markedly impaired in esophagectomy patients compared to patients who underwent a pancreaticoduodenectomy and could be prevented by early administration of a small dose dobutamine. PMID: 22012833 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5347723 Sat, 01 Jan 2011 05:00:00 +0100 5347723 http://www.medworm.com/index.php?rid=5180369&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876229%26dopt%3DAbstract Authors: Gori T, Jung F PMID: 21876229 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180369 Sat, 01 Jan 2011 00:00:00 +0100 5180369 http://www.medworm.com/index.php?rid=5180368&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876230%26dopt%3DAbstract Authors: Gehmert S, Gehmert S, Hidayat M, Sultan M, Berner A, Klein S, Zellner J, Müller M, Prantl L Abstract Recently, it was shown that mesenchymal stem cells (MSCs) are capable of differentiating into endothelial cells which highlights the potential role of MSCs in neovascularization. In the present study, we investigated the paracrine factors responsible for tube formation in human adipose-tissue derived stem cells (ASCs). Moreover, we analyzed ASC's migration towards PDGF-BB and altered levels of proteins involved in different pathways. Freshly isolated human adipose tissue-derived stem cells were seeded onto wells coated with Matrigel and cultured in endothelial growth medium. Capillary-like tube formation was observed after 18 hours culture. Tube formation was significantly... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180368 Sat, 01 Jan 2011 00:00:00 +0100 5180368 http://www.medworm.com/index.php?rid=5180367&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876231%26dopt%3DAbstract This study revealed that the angiopoietins provoked a differential response in the two endothelial cultures. Both angiopoietin 1 as well as angiopoietin 2 elicited an angiogenic cascade in the dermal ECs but not in the cardiac ECs. In addition, the RT-qPCR data revealed marked differences in the endogenous expression pattern of these factors, indicating that the origin of endothelial cells might have an important impact on their angiogenic potential. PMID: 21876231 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180367 Sat, 01 Jan 2011 00:00:00 +0100 5180367 http://www.medworm.com/index.php?rid=5180366&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876232%26dopt%3DAbstract In this study interconnectively macroporous PLGA scaffolds loaded with microporous and coated with nanoporous calcium phosphates were either seeded in fixed bed bioreactors with allogenic osteogenically induced mesenchymal stem cells and implanted or implanted unseeded into critical sized femoral bone defects. As CSD a 12 mm long segment of the chinchilla femur was excised where the proximal and distal parts of the femur were fixed and stabilized by the use of an eight-hole linear reconstruction plate and secured with three bicortical screws (2.7 mm diameter) on every side of the osteotomy. Aim of the study was if we could find a way to load and coat PLGA scaffolds with CaP so that shrinkage of scaffolds could be avoided, which would favour angiogenesis, blood supply and nutrition in the c... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180366 Sat, 01 Jan 2011 00:00:00 +0100 5180366 http://www.medworm.com/index.php?rid=5180365&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876233%26dopt%3DAbstract Authors: Franke RP, Fuhrmann R, Hiebl B, Jung F Abstract After intra-arterial administration of radiographic contrast media (RCM), a disorder of the downstream microcirculation both with regard to blood flow velocity in microvessels and to tissue oxygen partial pressure was described. Possible factors contributing to this microcirculatory disorder are increase in plasma viscosity, a formation of echinocytes, a buckling and denudation of endothelial cells, and a disturbation of endothelial prostacyclin release. It is not known so far whether the reactions observed in the context of RCM applications are reactions of venous endothelial cells alone or also of arterial endothelial cells. Therefore, arterial ECs on ECM were exposed to the same RCMs under identical conditions. The decreas... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180365 Sat, 01 Jan 2011 00:00:00 +0100 5180365 http://www.medworm.com/index.php?rid=5180364&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876234%26dopt%3DAbstract Authors: Mayer A, Lee S, Lendlein A, Jung F, Hiebl B Abstract Cardiovascular implants such as stents or artificial vascular grafts established in clinical application to date are generally designed as long-term implants. An important requirement for the successful application of these devices is the haemocompatibility of their interface to the blood stream, which often is approached by polymeric coatings. Modern therapies are aiming at curative treatments (Regenerative Medicine) by inducing the in vivo formation of a new endothelial layer on the implant surface ensuring an optimal haemocompatibility based on the generated glycocalyx. A promising approach for providing the required biological stimulus is the secretion of pro-angiogenic factors (such as VEGF-A) by autologous CD14+ mo... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180364 Sat, 01 Jan 2011 00:00:00 +0100 5180364 http://www.medworm.com/index.php?rid=5180363&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876235%26dopt%3DAbstract Conclusions: Treatment with telmisartan decreases the TNF-α-induced recruitment of monocytic cells and endothelial expression of VCAM-1 in regions of non-uniform shear stress in vitro. This mechanism can contribute to the beneficial pleiotropic effects of telmisartan in atherosclerosis-prone arterial regions. PMID: 21876235 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180363 Sat, 01 Jan 2011 00:00:00 +0100 5180363 http://www.medworm.com/index.php?rid=5180362&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876236%26dopt%3DAbstract Conclusions: The findings of this study demonstrated an increase of oxygen supply over the entire flap after hyperbaric oxygen therapy. PMID: 21876236 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180362 Sat, 01 Jan 2011 00:00:00 +0100 5180362 http://www.medworm.com/index.php?rid=5180361&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876237%26dopt%3DAbstract Conclusion: In this clinical trial, capillary perfusion after free flap transplantation as well as detection of vascular complications was demonstrated using CEUS. Quantitative perfusions analysis could be performed and flap viability could be assessed easily. PMID: 21876237 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180361 Sat, 01 Jan 2011 00:00:00 +0100 5180361 http://www.medworm.com/index.php?rid=5180360&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876238%26dopt%3DAbstract Conclusion: CEUS facilitates the detection and diagnosis of pathologic parathyroid glands due to their typical microvascularization. PMID: 21876238 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180360 Sat, 01 Jan 2011 00:00:00 +0100 5180360 http://www.medworm.com/index.php?rid=5180359&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876239%26dopt%3DAbstract Conclusion: At present, both technologies provide an optimal assessment of perfusion in cutaneous, subcutaneous and muscle tissue layers, whereby the detection of fatty tissue perfusion is currently more easily detected using CEUS compared to ceMRI. PMID: 21876239 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180359 Sat, 01 Jan 2011 00:00:00 +0100 5180359 http://www.medworm.com/index.php?rid=5180358&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876240%26dopt%3DAbstract Authors: Ruef P, Gehm J, Gehm L, Pöschl J Abstract Red blood cells (RBC) of neonates have a shorter survival time and they are more susceptible to mechanical alterations than RBC of adults. Irreversible alteration of the membrane of RBC of preterm neonates, term neonates and adults due to tether formation was studied by means of a micropipette technique. Shear stress and forces were applied with this technique in an axisymmetric configuration and were calculated with an approximation method. The applied shear stress and forces that induced tether formation were lowest for RBC of preterm neonates (1.5 Pa, 1.8 pN), in between for RBC of neonates (1.7 Pa, 2.1 pN) and highest for RBC in adults (1.9 Pa, 2.6 pN). Decreased mechanical stability of the membrane of neonatal RBC may in part... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180358 Sat, 01 Jan 2011 00:00:00 +0100 5180358 http://www.medworm.com/index.php?rid=5180357&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876241%26dopt%3DAbstract Authors: Jung F, Mrowietz C, Hiebl B, Franke RP, Pindur G, Sternitzky R Abstract One thousand two hundred and fifty-six subjects (apparently healthy subjects and patients with cardiovascular diseases) were registered in a prospective study including demographical and clinical data, rheological parameters (hematocrit, plasma viscosity, erythrocyte aggregation, erythrocyte deformability) as well as the erythrocyte velocity in human nailfold capillaries under resting and postischemic conditions. A multivariate regression analysis showed that under resting conditions there was no correlation between rheological parameters and erythrocyte velocity in capillaries. The blood flow regulation seemed to be so effective, that pathological changes of the blood fluidity showed no effect on the ... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180357 Sat, 01 Jan 2011 00:00:00 +0100 5180357 http://www.medworm.com/index.php?rid=5180356&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876242%26dopt%3DAbstract Conclusion: Contrast-enhanced ultrasound allows the non invasive, dynamic evaluation of neovascularisation within carotid plaques. PMID: 21876242 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180356 Sat, 01 Jan 2011 00:00:00 +0100 5180356 http://www.medworm.com/index.php?rid=5180355&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876243%26dopt%3DAbstract Conclusion: CEUS as a fast and bedside available imaging modality not associated with dose exposure or renal toxicity facilitates improved detection of ischaemic lesions and AVFs compared to standard US and thus should be considered for short term follow up of renal transplants. PMID: 21876243 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180355 Sat, 01 Jan 2011 00:00:00 +0100 5180355 http://www.medworm.com/index.php?rid=5180354&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876244%26dopt%3DAbstract Authors: Battig A, Hiebl B, Feng Y, Lendlein A, Behl M Abstract Polydepsipeptides, alternating copolymers consisting of α-amino acids and α-hydroxy acids, are degradable polymers. Depsipeptide-based polymers of varied architectures can be synthesized via ring-opening polymerization of various morpholine-2,5-dione derivatives. Thermoplastic phase-segregated multiblock copolymers with poly(ε-caprolactone) (PCL) and poly(iso-butyl-morpholinedione) segments have been synthesized from the macrodiols and an aliphatic diisocyanate as a coupling agent. The respective multiblock copolymers showed shape-memory capabilities and good elastic properties, making them attractive candidates for potential application as biomaterials for controlled drug release systems, scaffolds to be applied in... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180354 Sat, 01 Jan 2011 00:00:00 +0100 5180354 http://www.medworm.com/index.php?rid=5180353&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876245%26dopt%3DAbstract Conclusion: While in the human Leriche's syndrome months are needed to enlarge the EGAs for a partial collateral support of an infrarenal aortic occlusion the pig's EGA is a naturally sufficient collateral system capable to cover immediately for an acute infrarenal aortic occlusion. Further collateral enlargement even provides a permanent, sufficient hind limb perfusion in pigs. As the sufficient collateral system probably reduce pressure and shear rates in the infrarenal aortic segment after cross clamping, pigs might have a higher predisposition to produce early thrombosis related graft occlusions tan humans. PMID: 21876245 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180353 Sat, 01 Jan 2011 00:00:00 +0100 5180353 http://www.medworm.com/index.php?rid=5180352&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876246%26dopt%3DAbstract Authors: Fellner C, Prantl L, Rennert J, Stroszczynski C, Jung EM Abstract Postoperative monitoring of transplanted free flaps is an essential tool to reveal possible complications. The aim of this study was to compare the value of time-intensity-curve- (TIC-) analysis based on grey scale data of contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI). Postoperative imaging was performed in 11 patients following free flap transplantation and TIC analysis was obtained in identical regions of interest (ROI) of CEUS and DCE MRI data. Microcirculation was assessed in superficial (0-1 cm), middle (1-2 cm), and deep (2-3 cm) ROIs in one or two different positions within the flap resulting in a total of 46 ROIs evaluated (in very thin flap... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180352 Sat, 01 Jan 2011 00:00:00 +0100 5180352 http://www.medworm.com/index.php?rid=5180351&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21876247%26dopt%3DAbstract Conclusion: Contrast enhanced ultrasound is a reliable method for the evaluation of in-stent restenosis after carotid stenting of the ICA. CEUS provides a reduction in intrastenotic flow artefacts, resulting in better visualisation and detection of the complete length of the stenosis in comparison with CCDS and power Doppler. In order to elucidate hemodynamic changes, additional Doppler examinations are still necessary. PMID: 21876247 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=5180351 Sat, 01 Jan 2011 00:00:00 +0100 5180351 http://www.medworm.com/index.php?rid=4922775&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654053%26dopt%3DAbstract Conclusions: Treatment with 80 mg atorvastatin did not affect platelet aggregation and major hemorheologic parameters. The finding of an increase of homocysteine plasma levels in the presence of rather elevated levels of folic acid needs further investigation. PMID: 21654053 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4922775 Sat, 01 Jan 2011 00:00:00 +0100 4922775 http://www.medworm.com/index.php?rid=4922774&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654054%26dopt%3DAbstract This study is designed to determine an optimal haematocrit in normal (AA), sickle cell trait (AS) and sickle cell disease (SS) subjects. Twenty-seven apparently healthy subjects having normal haemoglobin genotype, 24 with sickle cell trait and 42 with homozygous sickle cell disease were recruited into the study. Whole blood viscosity (WBV) was measured by a Wells Brookfield Cone and Plate Viscometer at a shear rate of 230 sec-1. Haematocrit was determined by an AC.Tron Coulter Counter. The optimal haematocrit was calculated as the inverse of a constant, K, which was derived from the haematocrit and viscosity data. Our findings showed that the H0 varied significantly among the 3 haemoglobin genotypes, in the order AA vs SS and AS vs SS. Additionally, the data indicated an increased H0 in su... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4922774 Sat, 01 Jan 2011 00:00:00 +0100 4922774 http://www.medworm.com/index.php?rid=4922773&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654055%26dopt%3DAbstract Conclusion: Running exercise in tropical climate with ad libitum hydration does not alter the main rheological properties of blood. PMID: 21654055 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4922773 Sat, 01 Jan 2011 00:00:00 +0100 4922773 http://www.medworm.com/index.php?rid=4922772&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654056%26dopt%3DAbstract Conclusions: Amounts of sCD40L accumulation and release capacity during storage of platelet concentrates were dependent on storage duration, but showed no relevant differences regarding the preparation technique. After 5 days of storage, CD40L basal levels were increased, in contrast sCD40L release capacity was decreased. By recalcification and clot formation sCD40L release capacity could be easily induced and is assumed to be used as a marker for platelet viability. PMID: 21654056 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4922772 Sat, 01 Jan 2011 00:00:00 +0100 4922772 http://www.medworm.com/index.php?rid=4922771&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654057%26dopt%3DAbstract Authors: Spengler MI, Svetaz MJ, Leroux MB, Bertoluzzo SM, Carrara P, Van Isseldyk F, Petrelli D, Parente FM, Bosch P Systemic Lupus Erythematosus (SLE) is an autoimmune, chronic inflammatory, non-organ specific disease. SLE patients present a high prevalence of thrombotic and arteriosclerotic disease. The aim of the present work was to study the erythrocyte aggregation kinetics, and the effect of plasma factors, namely, immunoglobulin and fibrinogen concentration, as well as cell factors such as deformability and erythrocyte membrane lipid fluidity on the erythrocyte aggregation, in SLE patients and healthy controls. The results show that SLE patients red blood cells aggregate at higher rate and the aggregates size are also greater than controls due to an increase of immunoglobulin an... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4922771 Sat, 01 Jan 2011 00:00:00 +0100 4922771 http://www.medworm.com/index.php?rid=4922770&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654058%26dopt%3DAbstract Authors: Vayá A, Suescun M, Micó L, Todolí J, Ricart JM Rheological blood behavior in primary Sjögren's syndrome (SS) has been scarcely investigated. We evaluated the rheological profile (blood viscosity, plasma viscosity, erythrocyte deformability, erythrocyte aggregation, erythrocyte aggregation time and erythrocyte disaggregation threshold) along with fibrinogen, high-sensitive C reactive protein, plasma lipids, immunoglobulins, total proteins and erythrocyte sedimentation rate in 22 patients with primary SS (2 males, 20 females, aged 58 ± 9 years) and in 22 healthy volunteers (3 males, 19 females, aged 57 ± 5 years). Patients showed statistically higher plasma viscosity, erythrocyte sedimentation rate and G immunoglobulin (IgG) levels and lower total cholesterol than controls... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4922770 Sat, 01 Jan 2011 00:00:00 +0100 4922770 http://www.medworm.com/index.php?rid=4922769&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654059%26dopt%3DAbstract Authors: Baskurt OK, Uyuklu M, Ozdem S, Meiselman HJ A new method is described in this paper that allows measurement of red blood cell (RBC) aggregation indexes in disposable glass tubes within minutes. Light transmission through the RBC suspension filled into a microhematocrit capillary at stasis is recorded during RBC aggregation; a novel method assures an initial dispersion of aggregates in the capillary. The resulting light transmittance-time data are analyzed to calculate various parameters. Measurement of erythrocyte sedimentation rate (ESR) and RBC aggregation using well established methods and the newly developed capillary tube aggregometer in blood samples with a wide range of RBC aggregation indicated significant correlations between these parameters. Additionally, light tran... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4922769 Sat, 01 Jan 2011 00:00:00 +0100 4922769 http://www.medworm.com/index.php?rid=4769229&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498895%26dopt%3DAbstract Authors: Spengler MI, Rasia M, Palma S, Allemandi D 6-O-alkyl ascorbic acid esters (ASCn) are amphiphilic molecules that behave as surfactants in aqueous solution. ASCn have shown some physical and rheological properties that suggest a potential utility as drug carriers. The present paper aims to evaluate the effect of ASCn on erythrocyte properties in order to get information regarding the relationship between osmotic fragility, erythrocyte deformability and membrane lipoperoxidation process. The assays were performed at the following concentrations: the critical micelar concentration (CMC), producing 10% hemolysis (CH10) and producing 50% hemolysis (CH50). We observed that ASCn (ASC8, ASC10 and ASC12), at concentration nearby CMC, neither affected cell deformability nor produced lipo... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769229 Sat, 01 Jan 2011 00:00:00 +0100 4769229 http://www.medworm.com/index.php?rid=4769228&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498896%26dopt%3DAbstract Authors: Dąbrowski Z, Dybowicz AJ, Marchewka A, Teległów A, Skotnicki A, Zduńczyk A, Aleksander P, Filar-Mierzwa K The principal aim of the study was to investigate rheological properties of erythrocytes obtained from patients admitted to the clinic, and diagnosed with polycythemia vera. The polycythemia vera diagnosis was based on the WHO criteria for polycythemia vera. Using a laser rheometer SSD Rheometer-Rheodyn, the elongation index of erythrocytes was determined, indicating an increased rigidity of the erythrocytes in this disease compared with the erythrocytes in healthy people. In order to explain (albeit partially) the reason for reduced elasticity, the erythrocytes of patients with polycythemia were studied for the activity of enzymes - glucose-6-phosphate dehydrogenase a... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769228 Sat, 01 Jan 2011 00:00:00 +0100 4769228 http://www.medworm.com/index.php?rid=4769227&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498897%26dopt%3DAbstract In conclusion, PEGs had a potential hyperaggregating effect on human RBC. This effect is correlated with PEG molecular weight and concentration. The use of large molecular weight and high concentration PEG in UW solution accounts for extended and accelerated aggregation of erythrocytes. The use of low concentration PEG35kDa (1 g/L) would be the optimal choice. PMID: 21498897 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769227 Sat, 01 Jan 2011 00:00:00 +0100 4769227 http://www.medworm.com/index.php?rid=4769226&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498898%26dopt%3DAbstract Authors: You Y, Liu W, Li Y, Zhang Y, Li D, Li W, Yin X, Liao F, Zhu X, Liu C This work is to investigate the joint effect of extract from Shenlian (SL, the Chinese abbreviation for Radix Salviae miltiorrhizae and Andrographis paniculata) and swimming on atherosclerosis prevention and treatment. Atherosclerotic rat model was established by combining low shear stress by partial ligation of common carotid artery with afterwards feeding of a hyperlipotic diet. Sprague-Dawley rats after partial ligation of common carotid artery were allotted to a 3 × 3 factorial design with three levels of swimming (0, 1, and 2 hr per day) and three levels of SL extract (0, 2.56, and 5.12 g/kg once daily p.o.) for a total of 9 treatment groups. Then, the feeding of the hyperlipotic diet and the interventi... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769226 Sat, 01 Jan 2011 00:00:00 +0100 4769226 http://www.medworm.com/index.php?rid=4769225&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498899%26dopt%3DAbstract Authors: Du Y, Yao W, Qian Y, Han M, Wen Z, Ma L Living-donor renal transplantation is the preferred treatment for patients with end stage renal disease since it affords earlier transplantation and better graft for long term survival. The aim of the present study was to explore the hemorheological changes in patients undergone living-donor renal transplantation. We investigated the dynamic changes in the hemorheological properties of blood taken from the patients before renal transplantation and at 1 week, 2 week, 3 week and >1 month after the operation. As compared with pre-operation, the whole blood viscosity at different shear rates decreased significantly; the erythrocyte aggregation index decreased; the erythrocyte deformation index (DI) and integrated deformation index (IDI) h... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769225 Sat, 01 Jan 2011 00:00:00 +0100 4769225 http://www.medworm.com/index.php?rid=4769224&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498900%26dopt%3DAbstract Authors: Lim H, Nam J, Xue S, Shin S Even though blood coagulation can be tested by various methods and techniques, the effect of RBC aggregation on blood coagulation is not fully understood. The present study monitored clot formation in a microchip-based light transmission aggregometer. Citrated blood samples with and without the addition of calcium ion solution were initially disaggregated by rotating a stirrer in the microchip. After abrupt stop of the rotating stirrer, the transmitted light intensity over time was recorded. The syllectogram (light intensity vs. time graph) manifested a rapid increase that is associated with RBC aggregation followed by a decrease that is associated with blood coagulation. The time to reach the peak point was used as a new index of coagulation time (... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769224 Sat, 01 Jan 2011 00:00:00 +0100 4769224 http://www.medworm.com/index.php?rid=4769223&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498901%26dopt%3DAbstract Authors: El-Sayed MS, Ali N, Omar AA The aim of the present study was ascertain the effects posture and exercise modality on the main determinants of blood rheology. Thirteen subjects performed two exercise trials, in random order, at approximately 70% VO2 max for 45-min. One trial was performed on a motorized treadmill at an intensity corresponding to 70% VO2 max, while the other was performed on a stationary pike at an intensity corresponding to 70% VO2 max. In the cycling trial subjects stood for 30-min, followed by sitting for 30-min then cycled for 30-min at 70% VO2 max. In the treadmill trial, subjects sat for 30-min followed by standing for 30-min then ran on the treadmill for 30-min at 70% VO2 max. Variations of body postures prior to exercise were associated with opposite chan... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769223 Sat, 01 Jan 2011 00:00:00 +0100 4769223 http://www.medworm.com/index.php?rid=4769222&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21498902%26dopt%3DAbstract In this study, we introduce the Eadie-Hofstee transformation as an alternative linearization method for the analysis of RBC deformability. RBCs were treated with hydrogen peroxide (H2O2), tert-butyl-hydroperoxide (t-BuOOH), or methyl β-cyclodextrin (MβCD) and analyzed via ektacytometry (LORCA). RBC hemopathological clinical isolates (hereditary spherocytosis and α-thalassemia) were also analyzed by LORCA. Following ektacytometry, Eadie-Hofstee linearization was performed to obtain the maximum deformability (EImax) and shear stress at half maximal deformation (KEI) parameters. Significant changes in deformability parameters were observed with all agents tested. For H2O2 and t-BuOOH, the KEI values increased significantly accompanied by marginal changes in EImax, while treatment with MβC... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4769222 Sat, 01 Jan 2011 00:00:00 +0100 4769222 http://www.medworm.com/index.php?rid=4490094&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321403%26dopt%3DAbstract In conclusion, (1) improvement of FCD and arteriolar blood flow improved survival time; (2) VR recovered FCD and arteriolar blood flow and (3) in combination to VR, both dopamine doses reduced tissue perfusion (its low dose yielded the worst result). PMID: 21321403 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490094 Sat, 01 Jan 2011 00:00:00 +0100 4490094 http://www.medworm.com/index.php?rid=4490093&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321404%26dopt%3DAbstract This study mainly indicated that the plasma concentration of microparticles from platelets and polymorphonuclear neutrophils (PMN) was increased immediately after the strenuous exercise. In addition, the increase in plasma concentration of microparticles from PMN and platelets was still observed after 2 hours of recovery. A similar pattern was observed for the IL-6 plasma level. In contrast, no change was observed for either soluble selectins or plasma concentration of microparticles from red blood cells, monocytes and endothelial cells. In agreement, sVCAM-1 and sICAM-1 levels were not changed by the exercise. We conclude that a strenuous exercise is accompanied by platelet- and PMN-derived microparticle production that probably reflects the activation of these two cell types. PMID: 2... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490093 Sat, 01 Jan 2011 00:00:00 +0100 4490093 http://www.medworm.com/index.php?rid=4490092&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321405%26dopt%3DAbstract In this study we aimed to evaluate the blood viscosity focusing on erythrocyte aggregation, erythrocyte deformability and plasma viscosity in SCF. Thirty-three patients with SCF (21 male, 54 ± 12.8 years) and 23 subjects with normal coronary arteries (13 male, 59 ± 10.3 years) were included in the study. Coronary flow was quantified by means of thrombolysis in myocardial infarction (TIMI) frame count and aggregation and deformability of erythrocytes were measured by an ektacytometer. Plasma viscosity was measured by a cone-plate viscometer. Aggregation amplitude (23 ± 3.8 au vs. 15.7 ± 6.1 au, respectively, p < 0.001) and area A index (area above syllectogram) (153.2 ± 30.7 au.s vs. 124.9 ± 49.3 au.s, respectively, p < 0.01) were higher in SCF patients. Aggregation half-time, a... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490092 Sat, 01 Jan 2011 00:00:00 +0100 4490092 http://www.medworm.com/index.php?rid=4490091&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321406%26dopt%3DAbstract Authors: Sitina M, Turek Z, Parizkova R, Lehmann C, Cerny V The purpose of our study was to evaluate changes of the cerebral microcirculation during the early stages of endotoxemia in mechanically-ventilated rabbits using Sidestream dark-field (SDF) imaging. Images were obtained using SDF imaging from the surface of the brain via craniotomy before and after rapid administration of a high dose of endotoxin or saline (control group). Although endotoxin shock was successfully induced, we have not found any significant alteration of the cerebral microcirculation during the shock. We speculate that either the model of sepsis with a rapid high dose of endotoxin does not reflect the usual progression of septic encephalopathy or some components other than cerebral microcirculatory alteration p... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490091 Sat, 01 Jan 2011 00:00:00 +0100 4490091 http://www.medworm.com/index.php?rid=4490090&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321407%26dopt%3DAbstract Authors: Arıhan O, Seringeç NB, Gürel Eİ, Dikmenoğlu NH Acrylamide which is formed via reaction of reducing sugars with amino acids during food processing at high temperatures is not only neurotoxic and carcinogenic, but it also damages erythrocyte membrane and generates micronucleated erythrocytes. In the present study, effects of chronic administration of acrylamide at a dose which does not induce neurotoxicity were evaluated on blood viscosity parameters (hematocrit, erythrocyte deformability, erythrocyte aggregation and plasma viscosity). Twenty adult male Sprague-Dawley rats were divided into control and acrylamide groups. The acrylamide group received 10 mg/kg/day acrylamide, whereas the control group received saline (vehicle), both in 10 ml/kg/day volume via gastric gavage.... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490090 Sat, 01 Jan 2011 00:00:00 +0100 4490090 http://www.medworm.com/index.php?rid=4490089&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321408%26dopt%3DAbstract Conclusion: Although in general, hyperhomocysteinemia does not seem to constitute an independent risk factor for cryptogenic stroke, it significantly increases the risk in obese subjects; therefore it is convenient to decrease its levels in this sub-group to minimize the risk. PMID: 21321408 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490089 Sat, 01 Jan 2011 00:00:00 +0100 4490089 http://www.medworm.com/index.php?rid=4490088&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321409%26dopt%3DAbstract Authors: Vayá A, Carmona P, Badia N, Pérez R, Mijares AH, Corella D Hyperhomocysteinemia (HH) and metabolic syndrome (MS) are associated with increased cardiovascular risk. However, whether there is a link between MS or its components and homocysteine levels in a population without cardiovascular disease is not well established. We conducted a case-control study in 61 MS patients (41 males, 20 females, aged 51 ± 11 years) and in 98 controls without MS (59 males, 39 females, aged 50 ± 10 years) to ascertain the association between MS and HH, and with inflammatory markers. MS was classified according to the updated ATPIII criteria [17]. No differences in homocysteine levels were observed when comparing MS patients and controls (12.0 ± 3.18 μM vs. 11.9 ± 3.5 μM, p = 0.829). No ass... Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490088 Sat, 01 Jan 2011 00:00:00 +0100 4490088 http://www.medworm.com/index.php?rid=4490087&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321410%26dopt%3DAbstract Conclusion: The present findings demonstrate that blood viscosity increases with age. This increase seems independent of classical CHD risk factors and is disjoined from haematocrit and plasma viscosity, suggesting a possible direct effect of aging on red blood cells. PMID: 21321410 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490087 Sat, 01 Jan 2011 00:00:00 +0100 4490087 http://www.medworm.com/index.php?rid=4490086&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21321411%26dopt%3DAbstract Authors: Vayá A, Carmona P, Badia N, Hernandez-Mijares A, Bautista D PMID: 21321411 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4490086 Sat, 01 Jan 2011 00:00:00 +0100 4490086 http://www.medworm.com/index.php?rid=4286895&cid=s_38101_19_f&fid=38101&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21174363%26dopt%3DAbstract Authors: PMID: 21174363 [PubMed - indexed for MEDLINE] (Source: Clinical Hemorheology and Microcirculation) Clinical Hemorheology and Microcirculation journals http://www.medworm.com/rss/comments.php?id=4286895 Fri, 24 Dec 2010 23:10:03 +0100 4286895