MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Interventions in Aging' source. Sat, 10 Oct 2009 19:29:45 +0100 http://www.medworm.com/index.php?rid=1456355&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D528 Siddharth Mukherjee1, Abhijit Date2, Vandana Patravale3, Hans Christian Korting4, Alexander Roeder4, Günther Weindl51Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (E.), Mumbai, India; 2Pharmaceutical R & D, Nicholas Piramal Research Center, Goregaon, Mumbai, India; 3Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Matunga, Mumbai, India; 4Department of Dermatology and Allergology, Ludwig-Maximilians University, Munich, Germany; 5Department of Dermatology, Eberhard KarlsUniversity Tübingen, Tübingen, GermanyAbstract: Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456355 Wed, 21 May 2008 13:54:09 +0100 1456355 http://www.medworm.com/index.php?rid=1456354&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D530 Toni L Ripley1, Jennifer S Chonlahan1, Robin E Germany21University of Oklahoma College of Pharmacy, 2University of Oklahoma College of Medicine, Oklahoma City, OK, USAAbstract: Candesartan cilexetil is a nonpeptide selective blocker of the angiotensin II receptor sub-type 1. It is a prodrug that is converted to its active metabolite during its variable absorption. It is highly protein bound with a small volume of distribution and a nine-hour half-life. Candesartan is one of two angiotensin receptor blockers approved for use in heart failure. MEDLINE was searched using OVID and PubMed to evaluate the evidence for using candesartan in patients with heart failure. Pharmacologic and pharmacokinetic evaluations, as well as clinical trials, were selected and are presented in this review. Clinica... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456354 Wed, 21 May 2008 13:54:09 +0100 1456354 http://www.medworm.com/index.php?rid=1456353&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D534  Konstantinos Hatzimouratidis2nd Department of Urology, Papageorgiou General Hospital, and Center for Sexual and Reproductive Health, Aristotle University of Thessaloniki, Thessaloniki, GreeceAbstract: Erectile dysfunction (ED) is a highly prevalent disease associated with aging as well as with several risk factors including hypertension, heart disease, obesity, dyslipidemia, diabetes, hypogonadism, drugs-related, and pelvic surgery. Many of these factors are components of the metabolic syndrome, a multiplex risk factor for cardiovascular disease (CVD). ED shares common risk factors with CVD. Endothelial dysfunction seems to be the early underlying pathophysiology across both conditions. The efficacy, tolerability and cardiovascular safety of sildenafil has been evaluated in numerous ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456353 Wed, 21 May 2008 13:54:09 +0100 1456353 http://www.medworm.com/index.php?rid=1456352&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D536 Steven J Hudak1, Javier Hernandez1, Ian M Thompson2 1Urology Service, Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, TX, USA; 2Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USAAbstract: Prostate cancer is one of the most complex and enigmatic oncologic problems in medicine. It is highly prevalent, particularly in elderly males. Unfortunately, its generally protracted and variable clinical course and high association with treatment-related morbidity raise serious questions about the ideal treatment strategy for the individual patient. 5 alphareductase (5AR) inhibitors have a dramatic effect on benign prostatic disease with low toxicity. Thus, there is much interest in the potential role of 5AR inhibitors in the p... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456352 Wed, 21 May 2008 13:54:09 +0100 1456352 http://www.medworm.com/index.php?rid=1456351&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D537 Wilbert S AronowDepartment of Medicine, Cardiology and Geriatrics Divisions, New York Medical College, Valhalla, NY, USAAbstract: Numerous randomized, double-blind, placebo-controlled studies and observational studies have demonstrated that statins decrease mortality and major cardiovascular events in older high-risk persons with hypercholesterolemia. The Heart Protection Study found that statins decreased mortality and major cardiovascular events in high-risk persons regardless of the initial level of serum lipids, age, or gender. The updated National Cholesterol Education Program (NCEP) III guidelines state that in very high-risk patients, a serum low-density lipoprotein (LDL) cholesterol level of <70 mg/dl is a reasonable clinical strategy, regardless of age. When a high-risk person ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456351 Wed, 21 May 2008 13:54:09 +0100 1456351 http://www.medworm.com/index.php?rid=1456350&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D538 Giovanni Vanni Frajese, Flavio Pozzi, Gaetano FrajeseDepartment of Internal Medicine, Chair of Endocrinology - University of Rome Tor Vergata, Rome, ItalyAbstract: Prevalence and severity of erectile dysfunction (ED) increase with aging and are often associated with illnesses, like diabetes mellitus, heart disease, and hypertension, pathologically characterized by endothelial dysfunction and whose prevalence increases with age. The assumption that ED is mainly a neurovascular disease is supported by the evidence that specific phosphodiesterase type 5 (PDE5) inhibition produces an efficient erection in a wide range of ages and conditions. The availability of specific PDE5 inhibitors has enabled the development of effective treatment strategies, in this contest, tadalafil may be considered a... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456350 Wed, 21 May 2008 13:54:09 +0100 1456350 http://www.medworm.com/index.php?rid=1456349&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D539 Kenneth T Eng1,3,4, Peter J Kertes2,3 1Hotel Dieu Hospital, Kingston, Canada; 2Sunnybrook Health Sciences Centre, Toronto, Canada; 3Department of Ophthalmology and Visual Sciences, University of Toronto, Canada; 4Department of Ophthalmology, Queen’s University, CanadaAbstract: Neovascular age-related macular degeneration (AMD) is a visually devastating condition resulting from choroidal neovascularization and secondary photoreceptor loss. Ranibizumab and bevacizumab are medications that target vascular endothelial growth factor (VEGF). While other therapies have demonstrated some ability to reduce the risk of losing vision from neovascular AMD, most patients continue to lose some degree of central visual acuity. There is growing evidence that intravitreal administration of ranibizuma... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456349 Wed, 21 May 2008 13:54:09 +0100 1456349 http://www.medworm.com/index.php?rid=1456348&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D540 Conclusion: Telemedicine can improve access to speech and language evaluation services which is relevant to both dementia and other neurological diseases of the elderly. In particular, this specific assessment tool can be used to provide evaluations in under-served rural areas. (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456348 Wed, 21 May 2008 13:54:09 +0100 1456348 http://www.medworm.com/index.php?rid=1456347&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D784 Conclusion: The distribution of the factors contributing to fecal incontinence in older people living at home differs from those cared for in nursing home and hospital wards settings. These differences need to be borne in mind when assessing people in different settings. Management appears to result in a cure for those who are not significantly disabled with loose stools as a cause for their fecal incontinence, but this would need to be confirmed by further research.Keywords: Older adults, fecal incontinence, risk factors, care settings, digital rectal examination, mortality (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456347 Wed, 21 May 2008 13:54:09 +0100 1456347 http://www.medworm.com/index.php?rid=1456346&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D785 Carlo Calabrese, Anna Fabbri, Giulio Di FeboDepartment of Internal Medicine and Gastroenterology, University of Bologna, ItalyAbstract: The prevalence of gastroesophageal reflux disease (GERD) increases with age and elderly are more likely to develop severe disease. Older patients often complain of less severe or frequent heartburn than younger patients and they may present with atypical symptoms such as dysphagia, weight loss, or extraesophageal symptoms. Proton pump inhibitors (PPIs) are central in the management of GERD and are unchallenged with regards to their efficacy. They are considered safe and more effective than histamine receptor antagonists for healing esophagitis and for preventing its recurrence using a long term maintenance treatment. PPI have minimal side effects and few s... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456346 Wed, 21 May 2008 13:54:09 +0100 1456346 http://www.medworm.com/index.php?rid=1456345&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D786 Christine M ChengDepartment of Clinical Pharmacy, University of California, San Francisco, CA, USAAbstract: Botulinum toxin type A injections are one of the most popular cosmetic procedures for diminishing the appearance of facial lines caused by habitual facial muscle contractions. Although the manufacturer’s labeling recommends botulinum toxin only for the treatment of glabellar lines among adults younger than 65 years of age, there is widespread use of the toxin for other cosmetic purposes and for patients who may be older than 65. Evidence-based safety and efficacy data on botulinum toxin use in elderly patients is limited. However, given the age-related skin changes and multifactorial causes of wrinkles in the elderly, as well as the higher risk for potential side effects due to... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456345 Wed, 21 May 2008 13:54:09 +0100 1456345 http://www.medworm.com/index.php?rid=1456344&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D787 Arrigo FG Cicero, Luca Laghi“D. Campanacci” Clinical Medicine & Applied Biotechnology Dept. Sant’Orsola-Malpighi Hospital – University of Bologna Via Massarenti, 9, 40138 Bologna, ItalyAbstract: Osteoarthritis is the most common form of arthritis. It is a progressive joint disease associated with aging. It may be found in the knees, hips, or other joints. It is estimated that costs associated with osteoarthritis exceed 2% of the gross national product in developed countries. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a mainstay in the treatment of inflammatory disease and are among the most widely used drugs worldwide. The main limitation in using NSAIDs consists in their side-effects, including gastrointestinal ulcerogenic activity and bronchospasm. The ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456344 Wed, 21 May 2008 13:54:09 +0100 1456344 http://www.medworm.com/index.php?rid=1456343&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D788 Anastasios S Dontas1, Nicholas S Zerefos2, Demosthenes B Panagiotakos3, Dimitrios A Valis21Hellenic Association of Gerontology and Geriatrics, Athens, Greece; 2Nephrological Clinic, Hygeia Hospital, Athens, Greece; 3Department of Nutrition–Dietetics,  Harokopio University, Athens, Greece; 3Nephrological Unit, Hygeia Hospital, Athens, GreeceAbstract: There are now several scientific studies that relate this traditional dietary pattern with the incidence of coronary heart disease, various types of cancer, and other diseases. The past years have several observational and clinical studies suggested the mechanisms by which this traditional diet may affect coronary risk. This review underlines the importance of the Mediterranean dietary patterns in the prevention of coronary heart dis... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456343 Wed, 21 May 2008 13:54:09 +0100 1456343 http://www.medworm.com/index.php?rid=1456342&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D789 Richard F WalkerInternational Society for Applied Research in Aging (SARA)I was recently invited by Dr. Paolo Marandola, a respected urologist with special interest in male aging, to contribute a manuscript for a new book he will be editing. The comprehensive publication, sponsored by Giovane Accademia Italiana Antieta(GAIA) Age-Management Foundation, Pavia, Italy, is tentatively entitled The ‘Manifesto’ for a Long Life. It addresses the diversity of issues associated with aging and its management. My contribution was to present some ideas on the evolution of medical practice from the “traditional” to an “anti-aging” approach. I was pleased with the subject because it seems obvious that the orientation of healthcare must evolve from curing disease to pro... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456342 Wed, 21 May 2008 13:54:09 +0100 1456342 http://www.medworm.com/index.php?rid=1456341&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D790 This article reviews the new techniques available to measure the impact that cataracts have not only on a patient’s visual acuity but also their general physical health, function, cognition, and emotional well-being. New research is described that takes into account these more holistic tests and how they can be used to judge the best time to refer and operate on a patient with cataracts.Keywords: eye disease, cataract, surgery, quality of life, visual impairment (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456341 Wed, 21 May 2008 13:54:09 +0100 1456341 http://www.medworm.com/index.php?rid=1456340&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D791 Tamas Fülöp1, Anis Larbi2, Katsuiku Hirokawa3, Eugenio Mocchegiani4, Bruno Lesourd5, Stephen Castle6, Anders Wikby7, Claudio Franceschi8, Graham Pawelec21Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Quebec, Canada; 2Tübingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Medical School, Tübingen, Germany; 3Department of Pathology and Immunology Ageing and Developmental Sciences, Tokyo-Medical and Dental University Graduate School, Tokyo, Japan; 4Immunology Center, Section Nutrition, Immunity and Ageing, Research Department, Italian National Research Centres on Ageing, INRCA, Ancona, Italy; 5Hopital Universitaire de Clermont-Ferrand, Service Soins de Suite, R... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456340 Wed, 21 May 2008 13:54:09 +0100 1456340 http://www.medworm.com/index.php?rid=1456339&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D793 Conclusions: Full length PTH, given intermittently as an abdominal subcutaneous injection, appears to be a safe and efficacious treatment option for high risk osteoporosis. More data are needed to determine its specific role in osteoporosis treatment.Keywords: postmenopausal osteoporosis, anabolic therapy, PTH (1–84) (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456339 Wed, 21 May 2008 13:54:09 +0100 1456339 http://www.medworm.com/index.php?rid=1456338&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D794 David S Senchina1, Marian L Kohut21Biology Department, Drake University, Des Moines, IA, USA; 2Gerontology Program, Department of Health and Human Performance, Iowa State University, Ames, IA, USAAbstract: Aging is associated with a dysregulation of the immune system known as immunosenescence. Immunosenescence involves cellular and molecular alterations that impact both innate and adaptive immunity, leading to increased incidences of infectious disease morbidity and mortality as well as heightened rates of other immune disorders such as autoimmunity, cancer, and inflammatory conditions. While current data suggests physical activity may be an effective and logistically easy strategy for counteracting immunosenescence, it is currently underutilized in clinical settings. Long-term, moderate p... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456338 Wed, 21 May 2008 13:54:09 +0100 1456338 http://www.medworm.com/index.php?rid=1456337&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D795 Silvia Migliaccio, Marina Brama, Giovanni SperaCattedra di Medicina Interna, Dipartimento di Fisiopatologia Medica, Università degli Studi di Roma “La Sapienza”, Italy Abstract: Osteoporosis is a skeletal metabolic disease characterized by a compromised bone fragility, leading to an increased risk of developing spontaneous and traumatic fractures. Osteoporosis is considered a multifactorial disease and fractures are the results of several different risk factors both extra- and intraskeletal. Thus bone fragility can be the end point of several different causes: a) failure to reach an optimal peak bone mass during growth; b) excessive bone resorption resulting in decreased bone mass and microarchitectural deterioration; c) inadequate formation upon an increased resorption ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456337 Wed, 21 May 2008 13:54:09 +0100 1456337 http://www.medworm.com/index.php?rid=1456336&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D796 Maria Luisa Onor, Marianna Trevisiol, Eugenio AgugliaDepartment of Clinical, Morphological and Technological Sciences, U.C.O. of Clinical Psychiatry, University of Trieste, Trieste, ItalyAbstract: Alzheimer’s disease is the most common form of dementia in industrialized countries. In the European Union, about 54% of dementia cases are believed to be due to Alzheimer’s disease. The condition is an age-related neurodegenerative disorder characterized by multiple cognitive deficiencies, including loss of memory, judgment, and comprehension. These manifestations are accompanied by behavioral and mood disturbances. Although no cure has yet been discovered for Alzheimer’s disease, symptomatic therapies are now widely available and offer significant relief to patients and benefi... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456336 Wed, 21 May 2008 13:54:09 +0100 1456336 http://www.medworm.com/index.php?rid=1456335&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D797 Conclusion: This study suggests vitamin C supplementation did not enhance functional recovery in undernourished ischemic stroke patients.Keywords: vitamin C; ischemic stroke; functional recovery (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456335 Wed, 21 May 2008 13:54:09 +0100 1456335 http://www.medworm.com/index.php?rid=1456334&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D799 Philip SambrookUniversity of Sydney, SydneyAbstract: Osteoporosis is a chronic condition that generally requires long-term therapy for fracture risk reduction to become apparent. Although the bisphosphonates have made a major contribution to how clinicians manage osteoporosis, compliance with therapy has generally been less in the real-world setting than seen in clinical trials. Less-frequently administered dosage regimens or nonoral routes may enhance compliance and so maximize the therapeutic benefit of bisphosphonates. Ibandronate is a nitrogen-containing bisphosphonate, whose high potency allows it to be administered orally or intravenously with extended dosing intervals. This paper will review the role of intravenous ibandronate in the treatment of postmenopausal osteoporosis.Keywords... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456334 Wed, 21 May 2008 13:54:09 +0100 1456334 http://www.medworm.com/index.php?rid=1456333&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D800 Daniel A Andersen1,5, Bernard A Roos1–4, Damian C Stanziano1,3, Natasha M Gonzalez3, Joseph F Signorile1–31Stein Gerontological Institute, Miami, FL; 2Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Miami, FL; 3Department of Exercise and Sport Sciences, University of Miami, Coral Gables, FL; 4Departments of Medicine and Neurology, University of Miami Miller School of Medicine, Miami, FL; 5Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, FL, USAAbstract: The relationship between perceived health and walker use has seldom been addressed. Concerns over falls and falls risk are precursors to walker use. We compared the SF-36 scores of 26 women and 14 men, mean age 86.8 ± 6.0 years based on walke... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456333 Wed, 21 May 2008 13:54:09 +0100 1456333 http://www.medworm.com/index.php?rid=1456332&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D801 Joe Miller, Thomas H TarterDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Benign prostatic hyperplasia (BPH) is a frequent cause of lower urinary symptoms, with a prevalence of 50% by the sixth decade of life. Hyperplasia of stromal and epithelial prostatic elements that surround the urethra cause lower urinary tract symptoms (LUTS), urinary tract infection, and acute urinary retention. Medical treatments of symptomatic BPH include; 1) the 5α-reductase inhibitors, 2) the α1-adrenergic antagonists, and 3) the combination of a 5α-reductase inhibitor and a α1-adrenergic antagonist. Selective α1-adrenergic antagonists relax the smooth muscle of the prostate and bladder neck without affecting the detrussor muscle... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456332 Wed, 21 May 2008 13:54:09 +0100 1456332 http://www.medworm.com/index.php?rid=1456331&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D802 Conclusion: Clearly there is a need to develop effective alternative conservative therapies for the increasing numbers of prostate cancer patients who will not tolerate definitive curative measures or simply choose a conservative approach. Although this prospective study had no control arm, was of limited duration and included only 23 participants, it did appear to show significant benefit to the majority of prostate cancer patients treated with selective nutritional and dietary therapy alone. Such treatments may provide a safe and effective long-term treatment alternative for some patients. Further study is encouraged.Keywords: Prostate cancer, prostatitis, prostate cancer nutrition, PSA, EPS, Gleason score, voiding symptoms, Mediterranean diet (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456331 Wed, 21 May 2008 13:54:09 +0100 1456331 http://www.medworm.com/index.php?rid=1456330&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D803 Larissa Zaulyanov, Robert S Kirsner Department of Dermatology and Cutaneous Surgery; University of Miami Miller School of Medicine, Miami, Florida, USAAbstract: Apligraf® (Organogenesis, Canton, MA) is a bi-layered bioengineered skin substitute and was the first engineered skin US Food and Drug Administration (FDA)-approved to promote the healing of ulcers that have failed standard wound care. Constructed by culturing human foreskin-derived neonatal fibroblasts in a bovine type I collagen matrix over which human foreskin-derived neonatal epidermal keratinocytes are then cultured and allowed to stratify, Apligraf provides both cells and matrix for the nonhealing wound. Its exact mechanism of action is not known, but it is known to produce cytokines and growth factors similar to hea... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456330 Wed, 21 May 2008 13:54:09 +0100 1456330 http://www.medworm.com/index.php?rid=1456329&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1038 Conclusions: While further research is needed, preliminary evidence suggests that the VA screens the most vulnerable age groups in both genders. Heightened awareness among primary care providers of elderly male patients at risk of osteoporosis can lead to early intervention and improved management of this age-related condition.Keywords: bone mineral density scans, osteoporosis, veterans (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456329 Wed, 21 May 2008 13:54:09 +0100 1456329 http://www.medworm.com/index.php?rid=1456328&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1039 This article addresses distance caregiving, proposes the use of technology innovation to support caregiving, and suggests a research agenda to better inform policy decisions related to the unique needs of this situation.Keywords: caregiving, family, distance, technology, elders (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456328 Wed, 21 May 2008 13:54:09 +0100 1456328 http://www.medworm.com/index.php?rid=1456327&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1040 Malaz Boustani1, Stephanie Munger1, Robin Beck2, Noll Campbell3, Michael Weiner11Indiana University Center for Aging Research, Regenstrief Institute, Inc, Indianapolis, IN, USA; 2Indiana University School of Medicine, Indianapolis, IN, USA; 3Wishard Health Services, Indianapolis, IN, USAAbstract: Approximately 50% of hospitalized elders have cognitive impairment (CI) that increases their vulnerability to hospital-acquired complications. Matching geriatric evaluation and recommendations to the true pace of hospital care may improve the care of elders in general, in particular those with CI. Integrating information technology into geriatric services (gero-informatics) might allow reduction of the time to implementation of geriatric recommendations and prevent the initiation of potentially ha... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456327 Wed, 21 May 2008 13:54:09 +0100 1456327 http://www.medworm.com/index.php?rid=1456326&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1041 Quan Q Dinh, Rodney SinclairDepartment of Dermatology, St Vincent’s Hospital, Fitzroy, Victoria, AustraliaAbstract: Fewer than 45% of women go through life with a full head of hair. Female pattern hair loss is the commonest cause of hair loss in women and prevalence increases with advancing age. Affected women may experience psychological distress and impaired social functioning. In most cases the diagnosis can be made clinically and the condition treated medically. While many women using oral antiandrogens and topical minoxidil will regrow some hair, early diagnosis and initiation of treatment is desirable as these treatments are more effective at arresting progression of hair loss than stimulating regrowth. Adjunctive nonpharmacological treatment modalities such as counseling, cosm... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456326 Wed, 21 May 2008 13:54:09 +0100 1456326 http://www.medworm.com/index.php?rid=1456325&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1042 Anna M FerraraDepartment of Haematological, Pneumological, Cardiovascular and Surgical Sciences, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, ItalyAbstract: Community-acquired pneumonia (CAP) remains a common cause of morbidity and a potentially life-threatening illness throughout the world mainly in elderly patients. Initial antibacterial treatment, usually empirical, should be as effective as possible in order to assure rapid clinical resolution and reduce high rates of hospitalization and mortality especially affecting aged patients. New fluoroquinolones with potent activity against the most important respiratory pathogens including Streptococcus pneumoniae, a key pathogen mainly in old patients with CAP, have been recently suggested by several international guid... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456325 Wed, 21 May 2008 13:54:09 +0100 1456325 http://www.medworm.com/index.php?rid=1456324&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1043 George A Heckman, Christopher J Patterson, Catherine Demers, Joye St.Onge, Irene D Turpie, Robert S McKelvieDepartment of Medicine, McMaster University, Hamilton, Ontario, CanadaAbstract: As populations age, heart failure (HF) is becoming increasingly common, and in addition to a high burden of morbidity and mortality, HF has an enormous financial impact. Though disproportionately affected by HF, the elderly are less likely to receive recommended therapies, in part because clinical trials of HF therapy have ignored outcomes of importance to this population, including impaired cognitive function (ICF). HF is associated with ICF, manifested primarily as delirium in hospitalized patients, or as mild cognitive impairment or dementia in otherwise stable outpatients. This association is likely t... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456324 Wed, 21 May 2008 13:54:09 +0100 1456324 http://www.medworm.com/index.php?rid=1456323&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1044 Cathy R KessenichDepartment of Nursing, University of Tampa, Tampa, FL 33606, USA; Nurse Practitioner, Private Practice, Tampa, FLAbstract: Osteoporosis is a systemic, metabolic disease that can result in debilitating fractures. The lasting effects of vertebral and hip fractures can cause acute and chronic pain, deformity, and emotional distress. Research evidence and clinical experience have determined that weight bearing and strength training exercise, fall prevention efforts, hip protectors, and some alternative therapies may assist patients in avoiding the pervasive and lasting effects of osteoporotic fractures. Clinicians should consider the recommendations of nonpharmacological measures to assist patients at risk for experiencing the culminating event of this destructive disease.Keyw... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456323 Wed, 21 May 2008 13:54:09 +0100 1456323 http://www.medworm.com/index.php?rid=1456322&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1045 Khalid RahmanSchool of Biomolecular Sciences, Liverpool John Moores University, Liverpool, England, UKAbstract: The interplay between free radicals, antioxidants, and co-factors is important in maintaining health, aging and age-related diseases. Free radicals induce oxidative stress, which is balanced by the body’s endogenous antioxidant systems with an input from co-factors and by the ingestion of exogenous antioxidants. If the generation of free radicals exceeds the protective effects of antioxidants, and some co-factors, this can cause oxidative damage which accumulates during the life cycle, and has been implicated in aging, and age dependent diseases such as cardiovascular disease, cancer, neurodegenerative disorders, and other chronic conditions. The life expectancy of the worl... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456322 Wed, 21 May 2008 13:54:09 +0100 1456322 http://www.medworm.com/index.php?rid=1456321&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1046 Enrico Tincani1, Mark A Crowther2, Fabrizio Turrini1, Domenico Prisco31Unità Operativa di Medicina Interna Cardiovascolare, Nuovo Ospedale Civile di Modena S.Agostino-Estense, Modena, Italy; 2McMaster University, St. Joseph’s Hospital and McMaster University, Hamilton, Canada; 3Dipartimento di Area Critica Medico Chirurgica, Universita’ di Firenze, Florence, ItalyAbstract: Venous thromboembolism (VTE) is a common complication among hospitalized patients. Pharmacological thromboprophylaxis has emerged as the cornerstone for VTE prevention. As trials on thromboprophylaxis in medical patients have proven the efficacy of both lowmolecular-weight heparins (LMWHs) and unfractionated heparin (UFH), all acutely medical ill patients should be considered for pharmacological thromb... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456321 Wed, 21 May 2008 13:54:09 +0100 1456321 http://www.medworm.com/index.php?rid=1456320&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1048 Han Yan1, Lin Li2, Xi Can Tang11State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; 2Unilever Research China, Shanghai, ChinaAbstract: Senile dementia is a syndrome in the elderly involving deficits in memory and cognition. There has been a long history of research and medical practice in dementia in China, during which the ancient Chinese people have formed a whole theory and accumulated abundant experience in the treatment of dementia. During recent decades, with new theories and technologies being digested and integrated, progress has been made in the medical and pharmacy research on senile dementia in China. In this review, we will focus on the traditional opinion, clinical practice, and recent progress in pharmacol... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456320 Wed, 21 May 2008 13:54:09 +0100 1456320 http://www.medworm.com/index.php?rid=1456319&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1263 Richard F WalkerInternational Society for Applied Research in Aging (SARA)Growth hormone replacement therapy (GHRT) using recombinant human growth hormone (rhGH) has been embraced by many age management practitioners as one of the most effective methods for opposing somatic senescence currently available. However, its routine use has been controversial because few clinical studies have been performed to determine the potential risks of long-term therapy. Also, certain medical and legal issues have not been resolved causing some practitioners to restrict their use of the product. Some of these issues include the fact that:Improper dosing can lead to side effects that may be serious in some patients, Injection of hGH creates unnatural conditions of exposure to the hormone that may erode norm... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456319 Wed, 21 May 2008 13:54:09 +0100 1456319 http://www.medworm.com/index.php?rid=1456318&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1431 This study aimed to test the efficacy of the “Tai Chi for Diabetes” form, developed to address health-related problems in diabetes, including mobility and physical function. Thirty-eight older adults with stable type 2 diabetes were randomized to Tai Chi or sham exercise, twice a week for 16 weeks. Outcomes included gait, balance, musculoskeletal and cardiovascular fitness, self-reported activity and quality of life. Static and dynamic balance index (−5.8 ± 14.2; p = 0.03) and maximal gait speed (6.2 ± 11.6%; p = 0.005) improved over time, with no significant group effects. There were no changes in other measures. Non-specific effects of exercise testing and/or study participation such as outcome expectation, socialization, the Hawthorne effect, or unmeasure... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456318 Wed, 21 May 2008 13:54:09 +0100 1456318 http://www.medworm.com/index.php?rid=1456317&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1433 Susan Stevenson1, Julie Thornton21Burns & Plastic Surgery Research Unit, 2Cutaneous Research, Medical Biosciences, School of Life Sciences, University of Bradford, Bradford, UKAbstract: In humans, structural and functional changes attributable to aging are more visibly evident in the skin than in any other organ. Estrogens have significant effects on skin physiology and modulate epidermal keratinocytes, dermal fibroblasts and melanocytes, in addition to skin appendages including the hair follicle and the sebaceous gland. Importantly, skin aging can be significantly delayed by the administration of estrogen. This paper reviews the effects of estrogens on skin and the mechanisms by which estrogens can alleviate the changes due to aging that occur in human skin. The relevance of estrogen ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456317 Wed, 21 May 2008 13:54:09 +0100 1456317 http://www.medworm.com/index.php?rid=1456316&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1434 Diane M BiskobingDepartment of Medicine, Virginia Commonwealth University, Richmond, VA, USAAbstract: In the elderly population, osteoporosis is a significant clinical problem leading to disability and even death. Many patients remain untreated, despite effective therapies, because of patients’ unwillingness to take current therapies or inability to tolerate the therapies. For this reason, ongoing research continues to search for more effective and tolerable osteoporosis agents. Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment. A new drug application (NDA) for postmenopausal osteoporosis prevention was recently submitted to the FDA. Preclinical and clinical studies with bazedoxifene demonstrate more tiss... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456316 Wed, 21 May 2008 13:54:09 +0100 1456316 http://www.medworm.com/index.php?rid=1456315&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1435 Consuelo H WilkinsDepartment of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO, USAAbstract: Osteoporosis is common among older adults and results in costly osteoporotic fractures. Screening for this metabolic bone disorder is warranted in most older adults and clinicians must be diligent in identifying persons at risk. The evaluation should include an assessment of risk factors for falls, a bone density test, and consideration of possible secondary causes of osteoporosis. Several medications are available to improve bone density and decrease fractures. Adequate calcium and vitamin D intake (and treatment of vitamin D deficiency) are paramount in the management of osteoporosis.Keywords: Osteoporosis, Fractures, Vitamin D (S... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456315 Wed, 21 May 2008 13:54:09 +0100 1456315 http://www.medworm.com/index.php?rid=1456314&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1436 Bruno Madeo, Lucia Zirilli, Giovanni Caffagni, Chiara Diazzi, Alessia Sanguanini, Elisa Pignatti, Cesare Carani, Vincenzo RochiraDepartment of Medicine, Endocrinology and Metabolism, and Geriatrics, University of Modena and Reggio Emilia, Ospedale S.Agostino – Estense di Baggiovara, Modena, ItalyAbstract: Age-related bone loss in men is a poorly understood phenomenon, although increasing data on the pathophysiology of bone in men is becoming available. Most of what we know on bone pathophysiology derives from studies on women. The well-known association between menopause and osteoporosis is far from been disproven. However, male osteoporosis is a relatively new phenomenon. Its novelty is in part compensated for by the number of studies on female osteoporosis and bone pathophysiology.... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456314 Wed, 21 May 2008 13:54:09 +0100 1456314 http://www.medworm.com/index.php?rid=1456313&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1437 Christina S McCrae1, Amanda Ross1, Ashley Stripling2, Natalie D Dautovich21Department of Clinical and Health Psychology, 2Department of Psychology, University of Florida, Gainesville, Florida, USAAbstract: Insomnia, the most common sleep disturbance in later life, affects 20%–50% of older adults. Eszopiclone, a short-acting nonbenzodiazepine hypnotic agent developed for the treatment of insomnia, has been available in Europe since 1992 and in the US since 2005. Although not yet evaluated for transient insomnia in older adults, eszopiclone has been shown to be safe and efficacious for short-term treatment (2 weeks) of chronic, primary insomnia in older adults (64–91 years). Clinical studies in younger adults (mean = 44 years) have shown eszopiclone can be used for 6–12 mon... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456313 Wed, 21 May 2008 13:54:09 +0100 1456313 http://www.medworm.com/index.php?rid=1456312&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1438 Andrius Baskys1,3, Anthony C Hou21Department of Psychiatry and Human Behavior; 2Program in Geriatrics, University of California at Irvine, Irvine, California; 3Memory Disorders Program, VA Health Care System Long Beach, Long Beach, California, USAAbstract: Vascular dementia is a common condition for which there are no effective approved pharmacological treatments available. Absence of effective treatments creates a difficult situation for those suffering from the disease, their caregivers, and healthcare providers. This review will address our current understanding of the mechanisms of nerve cell damage due to ischemia and summarize available clinical trial data on several commonly used compounds including memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline,... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456312 Wed, 21 May 2008 13:54:09 +0100 1456312 http://www.medworm.com/index.php?rid=1456311&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1439 This article summarizes the efficacy, contraindications, precautions, dosing and common side effects of these agents. All available clinical trials on trospium, solifenacin and darifenacin were reviewed to determine its place in therapy.Keywords: overactive bladder, urinary incontinence, pharmacologic management, antimuscarinic agents, anticholinergics (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456311 Wed, 21 May 2008 13:54:09 +0100 1456311 http://www.medworm.com/index.php?rid=1456310&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1440 The objective of this paper is to describe placement and characteristics of older patients discharged from an acute care for the elderly (ACE) unit. The study sample consists of 1,351 men and women aged 65 years or older that were discharged from the ACE Unit during a 12-month period. The mean number of discharges per month was 109.2 ± 28.4. Most of the subjects were discharged home or home with home health 841, 62.3%. The oldest elderly and patients who had been admitted from long term care institutions or from skilled nursing facilities to the ACE unit were less likely to return to home.Keywords: hospitalization, geriatric, discharge disposition (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456310 Wed, 21 May 2008 13:54:09 +0100 1456310 http://www.medworm.com/index.php?rid=1456309&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1441 Russell H SwerdlowDepartment of Neurology, University of Virginia School of Medicine, Charlottesville, VA, USAAbstract: Alzheimer’s disease (AD) is incredibly common. Increasing longevity ensures its prevalence will rise even further. Ongoing efforts to understand AD pathogenesis reveal numerous tantalizing leads. Formulating a comprehensive AD pathogenesis theory capable of incorporating these disparate leads, though, has proven difficult. This review discusses current attempts to formulate a comprehensive AD pathogenesis theory. In doing so, it focuses on clinical and molecular relationships between AD and aging. A better understanding of these relationships could inform and impact future development of AD-directed treatment strategies.Keywords: Alzheimer’s disease, aging, am... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456309 Wed, 21 May 2008 13:54:09 +0100 1456309 http://www.medworm.com/index.php?rid=1456308&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1442 Massimo Franchini1, Annarita Tagliaferri2, Pier Mannuccio Mannucci31Transfusion and Hemophilia Center, City Hospital of Verona, Italy; 2Regional Reference Center for Inherited Bleeding Disorders, University Hospital of Parma, Italy; 3Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, ItalyAbstract: After the increasing rate of deaths observed during the 1980s due to human immunodeficiency virus (HIV) infection, the health-related quality of life and life expectancy of persons with hemophilia have improved, mainly due to the progresses of replacement therapy and antiviral drugs and to the improvement of the global comprehensive care provided by speci... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456308 Wed, 21 May 2008 13:54:09 +0100 1456308 http://www.medworm.com/index.php?rid=1456307&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1443 Matteo Tosato1, Valentina Zamboni1, Alessandro Ferrini1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USAAbstract: Aging is commonly defined as the accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that are responsible for the increased risk of disease and death. The major theories of aging are all specific of a particular cause of aging, providing useful and important insights for the understanding of age-related physiological changes. However, a global view of them is needed when debating of a process which is still obscure in some of its aspects.... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456307 Wed, 21 May 2008 13:54:09 +0100 1456307 http://www.medworm.com/index.php?rid=1456306&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1444 Barbara Resnick1, Denise Orwig2, Christopher D’Adamo2, Janet Yu-Yahiro3, William Hawkes2, Michelle Shardell2, Justine Golden2, Sheryl Zimmerman4, Jay Magaziner21University of Maryland School of Nursing, 655 West Lombard Street, Baltimore, MD,21201, USA; 2University of Maryland School of Medicine, Howard Hall, Redwood Street, Baltimore MD 21201, USA; 3Department of Orthopaedic Surgery, Union Memorial Hospital, Baltimore, USA; 4University of North Carolina Chapel Hill, 301 Pittsboro St., CB#3550, Chapel Hill, NC 27599-3550, USAAbstract: Using a social ecological model, this paper describes selected intra- and interpersonal factors that influence exercise behavior in women post hip fracture who participated in the Exercise Plus Program. Model testing of factors that influence exercise b... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456306 Wed, 21 May 2008 13:54:09 +0100 1456306 http://www.medworm.com/index.php?rid=1456305&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1445 Raja Bobba1, Jonathan D Adachi21Department of Medicine, St. Joseph’s Healthcare - McMaster University, 2Department of Medicine, Alliance for Better Bone Health Chair in Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, ON, CanadaAbstract: Osteoporosis in men is an increasingly recognized problem with associated fracture morbidity and mortality. Treatment is limited, with the bisphosphonates being the mainstay of therapy. Risedronate has demonstrated fracture efficacy in women and efficacy has been recently been investigated in men. In men, risedronate either maintains or increases bone mineral density. In placebo controlled trials it has been shown to be safe and effective in preventing fractures.Keywords: male osteoporosis, risedronate, bone mineral density... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456305 Wed, 21 May 2008 13:54:09 +0100 1456305 http://www.medworm.com/index.php?rid=1456304&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1446 Michael H GoldGold Skin Care Center, Tennessee Clinical Research Center, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical School,Vanderbilt University Nursing School, Nashville, TN, USA; Huashan Hospital, Fudan University, Shanghai, ChinaAbstract: Hyaluronic acid fillers have become popular soft tissue filler augmentation agents over the past several years. They have helped revolutionize the filler market with a number of new products available for use for our patients. The purpose of this manuscript is to review the characteristics of the HA fillers and to review each of the current products currently available for use in the US.Keywords: hyaluronic acid, fillers, soft tissue augmentation, expression lines, aging face, collagen (Source: Clinical Interventions in A... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456304 Wed, 21 May 2008 13:54:09 +0100 1456304 http://www.medworm.com/index.php?rid=1456303&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1447 Sonia SalariDepartment Family and Consumer Studies, University of Utah, Salt Lake City, UT, USAAbstract: Intimate partner homicide suicide (IPHS) constitutes the most violent domestic abuse outcome, devastating individuals, families, neighborhoods and communities. This research used content analysis to analyze 225 murder suicide events (444 deaths) among dyads with at least one member 60 or older. Data were collected from newspaper articles, television news transcripts, police reports and obituaries published between 1999 and 2005. Findings suggest the most dangerous setting was the home and the majority of perpetrators were men. Firearms were most often employed in the violence. Relationship strife was present in some cases, but only slightly higher than the divorce rate for that age grou... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456303 Wed, 21 May 2008 13:54:09 +0100 1456303 http://www.medworm.com/index.php?rid=1456302&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1448 Summer L Williams, Kelly B Haskard, M Robin DiMatteoDepartment of Psychology, University of California, Riverside, CA, USA Abstract: There is growing evidence that the outcomes of health care for seniors are dependent not only upon patients’ physical health status and the administration of care for their biomedical needs, but also upon care for patients’ psychosocial needs and attention to their social, economic, cultural, and psychological vulnerabilities. Even when older patients have appropriate access to medical services, they also need effective and empathic communication as an essential part of their treatment. Older patients who are socially isolated, emotionally vulnerable, and economically disadvantaged are particularly in need of the social, emotional, and practical s... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456302 Wed, 21 May 2008 13:54:09 +0100 1456302 http://www.medworm.com/index.php?rid=1456301&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1449 Nancy A Pachana1, Rana M Woodward1, Gerard JA Byrne21School of Psychology, University of Queensland, Brisbane, Australia 2School of Medicine, University of Queensland, Brisbane, AustraliaAbstract: Phobias are common in later life, yet treatment research in this population remains scant. The efficacy of exposure therapy, in combination with other Cognitive-Behavioral Therapy (CBT) components, in the treatment of specific phobia with a middle and older aged sample was examined. Sixteen adults aged 45–68 with DSM-IV diagnosis of a specific phobia received a manualized intervention over ten weeks, and were compared with a control group. Results indicated significant time effects in the treatment group for the primary outcome variables of phobic severity and avoidance as well as secondary... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456301 Wed, 21 May 2008 13:54:09 +0100 1456301 http://www.medworm.com/index.php?rid=1456300&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1450 Michelle M Lee1, Cameron J Camp2, Megan L Malone21Midwestern University, Department of Behavioral Medicine, Downers Grove, IL , USA; 2Myers Research Institute of Menorah Park Center for Senior Living, Beachwood, OH, USA Abstract: Fourteen nursing home residents on a dementia special care unit at a skilled nursing facility took part in one-to-one intergenerational programming (IGP) with 15 preschool children from the facility’s on-site child care center. Montessori-based activities served as the interface for interactions between dyads. The amount of time residents demonstrated positive and negative forms of engagement during IGP and standard activities programming was assessed through direct observation using a tool developed for this purpose – the Myers Research Institute Enga... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456300 Wed, 21 May 2008 13:54:09 +0100 1456300 http://www.medworm.com/index.php?rid=1456299&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1451 Domenico Fusco1, Giuseppe Colloca1, Maria Rita Lo Monaco1, Matteo Cesari1,21Department of Gerontology, Geriatrics and Physiatry; Catholic University of Sacred Heart, Rome, Italy; 2Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FLAbstract: The free radical theory of aging hypothesizes that oxygen-derived free radicals are responsible for the age-related damage at the cellular and tissue levels. In a normal situation, a balanced-equilibrium exists among oxidants, antioxidants and biomolecules. Excess generation of free radicals may overwhelm natural cellular antioxidant defences leading to oxidation and further contributing to cellular functional impairment. The identification of free radical reactions as promoters of ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456299 Wed, 21 May 2008 13:54:09 +0100 1456299 http://www.medworm.com/index.php?rid=1456298&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D1452 Discussion: These results are encouraging in that the physical activity intervention appears to have been well tolerated by diverse subgroups of older adults. The role of prior behavior in predicting downstream adherence underscores the importance of developing proactive interventions for treating nonadherence in older adult populations.Keywords: Disability, Physical Activity, Older Adults, Adherence (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456298 Wed, 21 May 2008 13:54:09 +0100 1456298 http://www.medworm.com/index.php?rid=1456297&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2520 Richard F WalkerInternational Society for Applied Research in Aging (SARA)This issue of Clinical Interventions in Aging contains a quite interesting and informative article about a topic that is popular and also controversial among practitioners of age-management medicine. Appropriate to that controversy, Drs Hersch and Merriam (2008) have asked the question in the title of their paper, does the use of growth hormone secretagogues in age management medicine hold the promise of a fountain of youth, or that of a pool of Tantalus? While there is universal understanding of the fountain imagery, the meaning of the pool is perhaps less obvious. It derives, of course, from the Greek myth of Tantalus, who had both a hidden, divine sire and a mortal one. As the son of Zeus, he was uniquely favored ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456297 Wed, 21 May 2008 13:54:09 +0100 1456297 http://www.medworm.com/index.php?rid=1456296&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2521 Maria Garefalakis, Martha HickeySchool of Women’s and Infants’ Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, AustraliaAbstract: Estrogen-containing hormone therapy (HT) is the most widely prescribed and wellestablished treatment for menopausal symptoms. High quality evidence confirms that estrogen effectively treats hot flushes, night sweats and vaginal dryness. Progestins are combined with estrogen to prevent endometrial hyperplasia and are sometimes used alone for hot flushes, but are less effective than estrogen for this purpose. Data are conflicting regarding the role of androgens for improving libido and well-being. The synthetic steroid tibolone is widely used in Europe and Australasia and effectively treats hot fl... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456296 Wed, 21 May 2008 13:54:09 +0100 1456296 http://www.medworm.com/index.php?rid=1456295&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2522 Colleen L Casey, Christine A MurrayUniversity of Vermont, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Burlington, VT, USAAbstract: The goal of postmenopausal hormone therapy is to alleviate the symptoms that are associated with the loss of estrogen. Many formulations of estrogen and progestin are available, depending on the needs and circumstances of each individual woman. For postmenopausal women, the choice of whether or not to begin therapy requires knowledge of the risks and benefits of estrogen and/or progestin replacement. The purpose of this review is to describe the risks and benefits of hormonal therapy, focusing on estradiol/norethindrone acetate combination therapy.Keywords: postmenopausal hormone therapy, norethindrone acetat... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456295 Wed, 21 May 2008 13:54:09 +0100 1456295 http://www.medworm.com/index.php?rid=1456294&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2523 Travis M Falconer1, John W Eikelboom2, Graeme J Hankey3, Paul E Norman11School of Surgery, University of Western Australia, Fremantle Hospital, Western Australia; 2Department of Medicine, McMaster University, Hamilton, Canada; 3Department of Neurology, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western AustraliaAbstract: Symptomatic and asymptomatic peripheral arterial disease (PAD) is a common problem in the elderly. The management of PAD includes the prevention of cardiovascular events and relief of symptoms – most commonly intermittent claudication (IC). Both require treatment of the causes and consequences of atherothrombosis, but some strategies are more effective for prevention of cardiovascular events and others are more effective for the relief o... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456294 Wed, 21 May 2008 13:54:09 +0100 1456294 http://www.medworm.com/index.php?rid=1456293&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2524 Roger D Stanworth, T Hugh JonesCentre of Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, South Yorkshire, United Kingdom; Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, South Yorkshire, United KingdomAbstract: An international consensus document was recently published and provides guidance on the diagnosis, treatment and monitoring of late-onset hypogonadism (LOH) in men. The diagnosis of LOH requires biochemical and clinical components. Controversy in defining the clinical syndrome continues due to the high prevalence of hypogonadal symptoms in the aging male population and the non-specific nature of these symptoms. Further controversy surrounds setting a lower limit of normal testosterone, the limitations of the ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456293 Wed, 21 May 2008 13:54:09 +0100 1456293 http://www.medworm.com/index.php?rid=1456292&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2525 Helga HansdóttirDepartment of Geriatrics, Landspitali University Hospital, Landakoti, Reykjavik, IcelandAbstract: Raloxifene is a non-steroidal selective estrogen-receptor modulator (SERM) which is used for prevention and treatment of postmenopausal osteoporosis. Raloxifene decreases the incidence of vertebral fractures by 30%–50% in postmenopausal women with osteoporosis but has not been shown to decrease the incidence of hip fractures or other non-vertebral fractures. At the present time, estrogen-replacement therapy and bisphosphonate treatment are the only medical treatments that are proven to prevent hip fractures with the exception of vitamin D and calcium replacement, which has been shown to prevent hip fractures in elderly individuals and nursing home residents. Raloxi... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456292 Wed, 21 May 2008 13:54:09 +0100 1456292 http://www.medworm.com/index.php?rid=1456291&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2526 Lee P ShulmanDivision of Reproductive Genetics, Department of Obstetrics and Gynecology, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USAAbstract: The clinical aftermath of the reporting of the initial findings of the Women’s Health Initiative (WHI) in 2002 was a profound reduction in the use of hormone therapies by menopausal women. This reduction led to a well documented increase in vasomotor symptoms and vaginal atrophy among those women who discontinued their hormone regimens. However, another adverse impact among these women, as well as many other menopausal women, is the well recognized increased likelihood of osteoporosis resulting from the decline in circulating estradiol levels associated with natural and surgical menopause. Although the use of ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456291 Wed, 21 May 2008 13:54:09 +0100 1456291 http://www.medworm.com/index.php?rid=1456290&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2527 Klaus KA Witte1, Andrew L Clark21Academic Department of Cardiology, LIGHT Building, University of Leeds and Leeds General Infirmary, UK; 2Academic Department of Cardiology, Castle Hill Hospital, University of Hull, Hull, UKAbstract: Chronic heart failure (CHF) is common, and increases in incidence and prevalence with age. There are compelling data demonstrating reduced mortality and hospitalizations with adrenergic blockade in older patients with CHF. Despite this, many older patients remain undertreated. The aim of the present article is to review the potential mechanisms of the benefits of adrenergic blockade in CHF and the clinical data available from the large randomized studies, focusing particularly on older patients.Keywords: beta-blockers, chronic heart failure (Source: Clinical In... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456290 Wed, 21 May 2008 13:54:09 +0100 1456290 http://www.medworm.com/index.php?rid=1456289&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2528 Stephanie Ogden1, Miny Samuel2, Christopher EM Griffiths11Dermatology Centre, University of Manchester, Hope Hospital, Salford Manchester, M6 8HD, UK; 2RTI-Health Solutions, Williams House, Manchester Science Park, Lloyd Street North, Manchester M15 6SE, UKAbstract: Chronic sun exposure leads to photodamage, which is characterized clinically by fine and coarse wrinkles, dyspigmentation, telangiectasia, laxity, roughness and a sallow appearance. Many treatments claim to reduce the signs of photodamage, however evidence from randomized controlled trials (RCT) to support these claims is limited. The use of topical retinoids, particularly tretinoin, isotretinoin and tazarotene, has been shown to significantly reduce signs of photodamage both clinically and histologically. Over recent years a n... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456289 Wed, 21 May 2008 13:54:09 +0100 1456289 http://www.medworm.com/index.php?rid=1456288&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2529 Julia Hannum Rose1,2,3, Rosanne Radziewicz4, Karen F Bowman5, Elizabeth E O’Toole11Case Western Reserve University School of Medicine, Cleveland, OH, USA; 2Louis Stokes Cleveland VAMC-GRECC, Cleveland, OH, USA; 3Center for Health Care Research and Policy, Case at MetroHealth Medical Center, Cleveland, OH, USA; 4Department of Nursing, MetroHealth Medical Center, Cleveland, OH, USA; 5Department of Sociology, Case Western Reserve University, Cleveland, OH, USAAbstract: As our society ages, increasing numbers of older Americans will be diagnosed and eventually will die of cancer. To date, psycho-oncology interventions for advanced cancer patients have been more successful in reaching younger adult age groups and generally have not been designed to respond to the unique needs and preferen... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456288 Wed, 21 May 2008 13:54:09 +0100 1456288 http://www.medworm.com/index.php?rid=1456287&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2530 Blanca Roman1, Laura Carta2, Miguel Ángel Martínez-González3, Lluís Serra-Majem41Mediterranean Diet Foundation, University of Barcelona Science Park, Spain; 2Department of Biosystems and Applied Sciences, Unit of Physiology and Human Nutrition, University of Cagliari, Italy; 3Department of Epidemiology and Public Health, University of Navarra, Spain; 4Department of Clinical Sciences, University of Las Palmas de Gran Canaria, SpainAbstract: The Mediterranean diet is known to be one of the healthiest dietary patterns in the world due to its relation with a low morbidity and mortality for some chronic diseases. The purpose of this study was to review literature regarding the relationship between Mediterranean diet and healthy aging. A MEDLINE search was conducted l... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456287 Wed, 21 May 2008 13:54:09 +0100 1456287 http://www.medworm.com/index.php?rid=1456286&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2531 Clair Haslam1, Turo Nurmikko21The Walton Centre for Neurology and Neurosurgery, Liverpool, England, UK; 2The Pain Research Institute, Division of Neurological Science, University of Liverpool, Liverpool, England, UKAbstract: Interest and research into the mechanisms and treatment of neuropathic pain have increased during recent years, but current treatment is still far from satisfactory (Dworkin et al 2003; Attal et al 2006). The European Federation of Neurological Societies (EFNS) Task Force recently published guidelines for the pharmacological treatment of neuropathic pain (Attal et al 2006). However, no particular consideration is given as to how the recommendations are applicable to the elderly population. This paper will review the guidelines in relation to this population and evaluat... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456286 Wed, 21 May 2008 13:54:09 +0100 1456286 http://www.medworm.com/index.php?rid=1456285&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2532 Elizabeth C Hersch, George R MerriamVA Puget Sound Health Care System and University of Washington School of Medicine, Tacoma and Seattle, Washington USAAbstract: Although growth hormone (GH) is primarily associated with linear growth in childhood, it continues to have important metabolic functions in adult life. Adult GH deficiency (AGHD) is a distinct clinical entity, and GH replacement in AGHD can improve body composition, strength, aerobic capacity, and mood, and may reduce vascular disease risk. While there are some hormone-related side effects, the balance of benefits and risks is generally favorable, and several countries have approved GH for clinical use in AGHD. GH secretion declines progressively and markedly with aging, and many age-related changes resemble those of partial AGHD... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456285 Wed, 21 May 2008 13:54:09 +0100 1456285 http://www.medworm.com/index.php?rid=1456284&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2533 Michael P Cannito, Joel C Kahane, Lesya ChornaSchool of Audiology and Speech-Language Pathology, The University of Memphis, Memphis, TN, USAAbstract: Aging of the larynx is characterized by involutional changes which alter its biomechanical and neural properties and create a biological environment that is different from younger counterparts. Illustrative anatomical examples are presented. This natural, non-disease process appears to set conditions which may influence the effectiveness of botulinum toxin injection and our expectations for its success. Adductor spasmodic dysphonia, a type of laryngeal dystonia, is typically treated using botulinum toxin injections of the vocal folds in order to suppress adductory muscle spasms which are disruptive to production of speech and voice. A few stu... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456284 Wed, 21 May 2008 13:54:09 +0100 1456284 http://www.medworm.com/index.php?rid=1456283&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2534 This article reviews the innate properties of FDA-approved HA fillers and provides an insight on future HA products and their utilization for the management of the aging face.Keywords: hyaluronic acid, aging face, dermal filler, wrinkles, Restylane, Perlane, Juvéderm (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456283 Wed, 21 May 2008 13:54:09 +0100 1456283 http://www.medworm.com/index.php?rid=1456282&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2535 Patricio F JacovellaHospital de Clinicas, University of Buenos Aires, ArgentinaAbstract: Radiesse® (Bioform Inc, USA) is a sterile, latex-free, non-pyrogenic, semi-solid, cohesive subdermal, injectable implant, whose principal component is synthetic calcium hydroxylapatite, a biocompatible material with over 20 years of use in medicine. The semi-solid nature of the product is created by suspending calcium hydroxylapatite microspheres of 25–45 microns diameter in a gel carrier of carboxymethylcellulose. The product has FDA approval for esthetic facial augmentation in the US. Such approval includes the long-lasting correction of moderate to severe facial wrinkles and folds and the treatment of facial fat loss due to immunodeficiency virus infection. Diverse facial regions can be in... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456282 Wed, 21 May 2008 13:54:09 +0100 1456282 http://www.medworm.com/index.php?rid=1456281&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2536 Fiorenzo Angehrn1, Christoph Kuhn1, Ortrud Sonnabend2, Axel Voss31Klinik Piano, Biel, Switzerland; 2Pathodiagnostics, Herisau, Switzerland; 3SwiTech Medical AG, Kreuzlingen, SwitzerlandAbstract: In this prospective design study the effects of low-energy partially focused extracorporeal generated shock waves (ESW) onto a subcutaneous located varicose vein – left vena saphena magna (VSM) – are investigated. The treatment consisted of 4 ESW applications within 21 days. The varicose VSM of both sides were removed by surgery, and samples analyzed comparing the treated and untreated by means of histopathology. No damage to the treated varicose vein in particular and no mechanical destruction to the varicose vein’s wall could be demonstrated. However, an induction of neo-collage... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456281 Wed, 21 May 2008 13:54:09 +0100 1456281 http://www.medworm.com/index.php?rid=1456280&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2537 Conclusions: A combined oral Ca-D3 product (Osteoblast) is effective for treating vitamin D deficiency and is adequately tolerated. (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456280 Wed, 21 May 2008 13:54:09 +0100 1456280 http://www.medworm.com/index.php?rid=1456279&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2538 In conclusion, these observations enhance the pathogenic complexity of the Alzheimer syndrome, and suggest that the role of arteriosclerotic brain degeneration in late life dementia is underestimated.Keywords: Alzheimer’s disease, mild cognitive impairment, dementia, MRI, phase contrast, atherosclerosis (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456279 Wed, 21 May 2008 13:54:09 +0100 1456279 http://www.medworm.com/index.php?rid=1456278&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2539 Christoph Kuhn1, Fiorenzo Angehrn1, Ortrud Sonnabend2, Axel Voss31Klinik Piano, Biel, Switzerland; 2Pathodiagnostics, Herisau, Switzerland; 3SwiTech Medical AG, Kreuzlingen, SwitzerlandAbstract: In this case study of an unique instance, effects of medium-energy, high-focusedextracorporeal generated shock waves (ESW) onto the skin and the underlying fat tissue of acellulite afflicted, 50-year-old woman were investigated. The treatment consisted of four ESW applications within 21 days. Diagnostic high-resolution ultrasound (Collagenoson) was performed before and after treatment. Directly after the last ESW application, skin samples were taken for histopathological analysis from the treated and from the contra-lateral untreated area of skin with cellulite. No damage to the treated skin tissue... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456278 Wed, 21 May 2008 13:54:09 +0100 1456278 http://www.medworm.com/index.php?rid=1456277&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2694 Richard F WalkerInternational Society for Applied Research in Aging (SARA)Prior to the discovery of penicillin and production of antibiotics, extrinsic disease was the greatest threat to achieving maximum life potential (longevity). That single event increased life-span several decades for the majority of people living in first world nations. However, protection against lethal infection provided by antibiotics exposed older humans to a wide variety of life-threatening diseases resulting from disintegration of internal order during senescence. These intrinsic diseases including diabetes, stroke, heart attack, cancer, and a multitude of others, resulted in creation of medical subspecialties. Although each specialty focused upon different organs and systems, they all administered treatment in... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456277 Wed, 21 May 2008 13:54:09 +0100 1456277 http://www.medworm.com/index.php?rid=1456276&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2695 Richard F WalkerInternational Society for Applied Research in Aging (SARA)The Society for Applied Research in Aging (SARA) was founded to serve the needs of practitioners who seek to sustain health, vitality, and quality of life of their patients during aging. Recognizing that a most basic and important part of that task is to provide relevant professional information to its members, Clinical Interventions in Aging (CIA) was created as the official SARA journal. (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456276 Wed, 21 May 2008 13:54:09 +0100 1456276 http://www.medworm.com/index.php?rid=1456275&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2748 Swati Jha, Matthew ParsonsDepartment of Urogynaecology, Birmingham Women’s Hospital, Birmingham. UKAbstract: Anticholinergics are commonly used in primary and secondary care settings for the treatment of overactive bladder syndrome. The number of anticholinergic drugs available on the market is increasing and various studies, both observational and randomized controlled trials, have evaluated effectiveness of the different preparations available. When anticholinergic therapy is prescribed, there is still uncertainty about which anticholinergic drugs are most effective, at which dose, and by which route of administration. There is also uncertainty about the role of anticholinergic drugs in different patient groups, particularly in the elderly. The rationale for using anticholinergic d... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456275 Wed, 21 May 2008 13:54:09 +0100 1456275 http://www.medworm.com/index.php?rid=1456274&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2749 Fabrizio Stocchi1, Maria Francesca De Pandis21IRCCS San Raffaele Pisana, Roma, Italy; 2San Raffaele Cassino (FR), Roma, ItalyAbstract: Fluctuating Parkinson’s disease (PD) represents a clinical management challenge. The primary utility of levodopa in patients with PD is moderated by the “wearing off” phenomena seen with long-term use. COMT inhibitors slow down the rapid metabolism of levodopa, resulting in a more-sustained response to dopaminergic therapy. Tolcapone is a selective, reversible catechol-O-methyltransferase (COMT) inhibitor, shown to have both peripheral and central effects. In clinical trials, tolcapone has been shown to reduce “off” time, increase “on” time, improve patient and clinician assessments of disease severity, and improve ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456274 Wed, 21 May 2008 13:54:09 +0100 1456274 http://www.medworm.com/index.php?rid=1456273&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2750 Cheryl M BurgessCenter for Dermatology and Dermatologic Surgery, 2311 M Street, Northwest, Suite 504, Washington, D.C. 20037, USAAbstract: In the quest for the “ideal” soft tissue filler, many diverse products have been developed. The expanding market of available fillers is a testament that no one product will ideally suit all patients or clinicians. In addition, the challenge of satisfying the criteria of an ideal filler has driven researchers to take a variety of development paths. This has resulted in multiple categories to characterize soft tissue fillers. These fillers are categorized according to: (1) filler material, eg, autologous, natural, synthetic; (2) mechanism of action, eg, void filler, neocollagenesis, fibroblast stimulation; (3) patient type and profile, eg, yo... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456273 Wed, 21 May 2008 13:54:09 +0100 1456273 http://www.medworm.com/index.php?rid=1456272&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2751 Glen M Blake, Ignac FogelmanKing’s College London School of Medicine, London, UKAbstract: Strontium ranelate is a new orally administered agent for the treatment of women with postmenopausal osteoporosis that reduces the risk of vertebral and hip fractures. Evidence for the safety and efficacy of strontium ranelate comes from two large multinational trials, the SOTI (Spinal Osteoporosis Therapeutic Intervention) and TROPOS (Treatment Of Postmenopausal Osteoporosis) studies. The SOTI study evaluated vertebral fracture prevention in 1649 postmenopausal women with a mean age of 69 y. The subjects all had at least one previous vertebral fracture and a low spine bone mineral density (BMD) (equivalent to a Hologic spine T-score below –1.9). The strontium ranelate group had a 41% lowe... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456272 Wed, 21 May 2008 13:54:09 +0100 1456272 http://www.medworm.com/index.php?rid=1456271&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2752 This article reviews the currently available antiresorptive agents and their effects on the above outcome measures.Keywords: osteoporosis, postmenopausal, fracture, antiresorptive agents (Source: Clinical Interventions in Aging) Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456271 Wed, 21 May 2008 13:54:09 +0100 1456271 http://www.medworm.com/index.php?rid=1456270&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2753 Timothy J Wilt, Roderick MacDonaldMinneapolis Veterans Affairs Center for Chronic Disease Outcomes Research, the Cochrane Review Group in Prostate Diseases and Urologic Cancers, Veterans Affairs Medical Center, Minneapolis, USAAbstract: We evaluated the efficacy and safety of a1 - blocker doxazosin for treatment of lower urinary tract symptoms (LUTS) compatible with benign prostatic hypertrophy (BPH). Fourteen randomized controlled trials enrolled 6261 men, average age 64 years, who had moderately severe LUTS and flow impairment. Compared with baseline measures and placebo effect, doxazosin resulted in a statistically significant improvement in both LUTS and flow. However, when compared with placebo, the average magnitude of symptom improvement (International Prostate Symptom Score [IPSS] ... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456270 Wed, 21 May 2008 13:54:09 +0100 1456270 http://www.medworm.com/index.php?rid=1456269&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2754 Jean-Yves Reginster, Véronique RabendaWHO Collaborating Center for Public Health Aspects of Rheumatic Diseases, University of Liege, Liege, BelgiumAbstract: The leading treatments for postmenopausal osteoporosis are the nitrogen-containing bisphosphonates, which are required long term for optimal benefit. Oral bisphosphonates have proven efficacy in postmenopausal osteoporosis in clinical trials, but in practice the therapeutic benefits are often compromised by patients’ low adherence. Nonadherence to bisphosphonate therapy negatively impacts outcomes such as fracture rate; fractures are in turn associated with decreased quality of life. The most common reason cited by patients for their nonadherence is that the strict dosing instructions for bisphosphonates are difficult to f... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456269 Wed, 21 May 2008 13:54:09 +0100 1456269 http://www.medworm.com/index.php?rid=1456268&cid=s_33663_18_f&fid=33663&url=http%3A%2F%2Fdovepress.com%2Farticles.php%3Fcontent_id%3D2755 Ron Z Goetzel1, David Shechter2, Ronald J Ozminkowski1, David C Stapleton3, Pauline J Lapin4, J Michael McGinnis5, Catherine R Gordon6, Lester Breslow71Institute for Health and Productivity Studies, Cornell University, Washington, DC; 2Health and Productivity Research, Thomson Medstat, Santa Barbara, CA; 3Cornell Institute for Policy Research, Cornell University, Washington, DC; 4Office of Research, Development, and Information, Centers for Medicare and Medicaid Services, Baltimore, MD; 5National Academy of Sciences, Institute of Medicine, The National Academies, Washington, DC; 6Office of the Director, Centers for Disease Control and Prevention, Washington, DC; 7UCLA School of Public Health, Dept. of Health Services, Los Angeles, CA, USAAbstract: The impact of an aging population on escal... Clinical Interventions in Aging journals http://www.medworm.com/rss/comments.php?id=1456268 Wed, 21 May 2008 13:54:09 +0100 1456268