MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Neuropathology' source. Thu, 09 Feb 2012 00:42:09 +0100 http://www.medworm.com/index.php?rid=5542346&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192699%26dopt%3DAbstract Authors: Hainfellner JA PMID: 22192699 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542346 Mon, 26 Dec 2011 11:31:28 +0100 5542346 http://www.medworm.com/index.php?rid=5542345&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192700%26dopt%3DAbstract Authors: Weis J, Brandner S, Lammens M, Sommer C, Vallat JM Abstract Nerve biopsy is a valuable tool in the diagnostic work-up of peripheral neuropathies. Currently, major indications include interstitial pathologies such as suspected vasculitis and amyloidosis, atypical cases of inflammatory neuropathy and the differential diagnosis of hereditary neuropathies that cannot be specified otherwise. However, surgical removal of a piece of nerve causes a sensory deficit and - in some cases - chronic pain. Therefore, a nerve biopsy is usually performed only when other clinical, laboratory and electrophysiological methods have failed to clarify the cause of disease. The neuropathological work-up should include at least paraffin and resin semithin histology using a panel of conventional an... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542345 Mon, 26 Dec 2011 11:31:17 +0100 5542345 http://www.medworm.com/index.php?rid=5542344&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192701%26dopt%3DAbstract We report a 78-year-old male with known prostate carcinoma admitted with acute onset of blurred vision, suggestive of apoplexy. Work-up revealed unilateral cranial nerve VI palsy and neuroimaging showed a mass confined to the clivus; sellar region was normal. Preoperative considerations included chordoma, chondrosarcoma, or metastatic prostate carcinoma to bone. Resection was via endoscopic transsphenoidal approach to the clivus. An ectopic null cell pituitary adenoma with bland infarction was identified as the cause of the patient's clinical apoplexy. No antecedent precipitating factors for apoplexy were present; specifically the patient had not received leuprolide preoperatively, a known precipitant of pituitary apoplexy in prostate cancer patients who receive drug. We review the literat... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542344 Mon, 26 Dec 2011 11:31:06 +0100 5542344 http://www.medworm.com/index.php?rid=5542343&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192702%26dopt%3DAbstract Authors: Xiong J, Liu Y, Chu SG, Chen H, Chen HX, Mao Y, Wang Y Abstract Dysembryoplastic neuroepithelial tumor (DNT)-like neoplasms of the septum pellucidum are extremely rare. We reviewed 2 cases of DNT-like neoplasm of the septum pellucidum and specifically studied the immunohistochemical features and chromosomes 1p and 19q deletions. One case was a 26-year-old woman who complained of aggravated headache for 2 weeks. The other case was a 31-year-old female presenting with double vision for a month. Histological examinations showed that the lesions were composed of uniform oligodendrocytelike cells (OLCs) with obvious floating neurons in a mucin-rich background. Immunohistochemical studies revealed that both tumors were diffusely positive for Synaptophysin and Olig2. Sporadic neu... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542343 Mon, 26 Dec 2011 11:30:54 +0100 5542343 http://www.medworm.com/index.php?rid=5542342&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192703%26dopt%3DAbstract We report 2 cases that exhibited unusual histopathologic structure as well as a typical Zellballen pattern with a highly vascular stroma. The unusual features included papillary, ribboning, and pseudorosette patterns, ganglion cell nests, and melanin pigment. Pathological diagnosis of paraganglioma may be especially difficult when such unusual histopathological features are seen. Correct histopathological diagnosis is important as paraganglioma has a better prognosis than other tumors included in the differential diagnosis for this location. PMID: 22192703 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542342 Mon, 26 Dec 2011 11:30:43 +0100 5542342 http://www.medworm.com/index.php?rid=5542341&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192704%26dopt%3DAbstract We present neuropathological findings at autopsy following medical termination of pregnancy of a 23-week fetus with septo-optic dysplasia (SOD), optic nerve hypoplasia, absent septum pellucidum with aplastic posterior pituitary. PMID: 22192704 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542341 Mon, 26 Dec 2011 11:30:33 +0100 5542341 http://www.medworm.com/index.php?rid=5542340&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192705%26dopt%3DAbstract Authors: Martinez-Saez E, Malik I, Connor S, King A PMID: 22192705 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542340 Mon, 26 Dec 2011 11:30:23 +0100 5542340 http://www.medworm.com/index.php?rid=5542339&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192706%26dopt%3DAbstract Authors: Neal MT, Ellis TL, Stanton CA PMID: 22192706 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5542339 Mon, 26 Dec 2011 11:30:12 +0100 5542339 http://www.medworm.com/index.php?rid=5385372&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011732%26dopt%3DAbstract Authors: Hainfellner JA PMID: 22011732 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385372 Tue, 01 Nov 2011 04:00:00 +0100 5385372 http://www.medworm.com/index.php?rid=5385352&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011733%26dopt%3DAbstract We report an extremely rare rhabdoid, papillary and clear cell meningioma (WHO Grade III) in a 29-year-old female, who presented with diplopia and headache over a few days, 2 years ago. Magnetic resonance imaging showed a well-circumscribed, lobulated, predominantly solid and contrast-enhancing lesion in the right temporal, parietal and occipital lobes. On routine staining, the tumor did not display classical meningioma features. A wide immunohistochemical panel ruled out metastasis and endorsed the meningothelial nature of the lesion (positivity for epithelial membrane antigen and vimentin). Electron microscopy did not show usual hallmarks of meningioma but was helpful in excluding other tumors. Even though the three variants are associated with aggressive behavior, the patient is current... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385352 Tue, 01 Nov 2011 04:00:00 +0100 5385352 http://www.medworm.com/index.php?rid=5385351&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011734%26dopt%3DAbstract We report here the case of an 18-year-old with Noonan syndrome who developed a rosette forming glioneuronal tumor of the posterior fossa. The tumor demonstrated strong pERK immunoreactivity, suggesting MAPK/ERK pathway activation. Molecular testing did not reveal BRAF rearrangements (fusion transcripts) by PCR or a BRAFV600E mutation by sequencing. We review the literature regarding the molecular pathogenesis of Noonan syndrome and primary brain tumors, and consider the intriguing link between their common molecular pathways. PMID: 22011734 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385351 Tue, 01 Nov 2011 04:00:00 +0100 5385351 http://www.medworm.com/index.php?rid=5385350&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011735%26dopt%3DAbstract Conclusion: Astroblastomas are rare brain tumors and pose a challenge in the diagnostic and clinical approach. In general, they have an unpredictable course with a tendency of recurrence. This and other case reports support a survival benefit of chemotherapy, suggesting this as an important treatment option for these patients. PMID: 22011735 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385350 Tue, 01 Nov 2011 04:00:00 +0100 5385350 http://www.medworm.com/index.php?rid=5385349&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011736%26dopt%3DAbstract We report a case of a 48-year-old male operated on a primary glioblastoma, followed by radiotherapy. A local recurrence occurred 23 months later that was operated too, and a second diagnosis of a fibrosarcoma with true epithelial differentiation was made. Primary systemic neoplasms were largely excluded. The patient died shortly after, and postmortem showed another cerebral dural-attached mass corresponding to a sarcoma without epithelial differentiation, and leptomeningeal seeding composed of malignant epithelial elements only. Cytogenetics, however, disclosed the second tumor to be similar to the primary one. PMID: 22011736 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385349 Tue, 01 Nov 2011 04:00:00 +0100 5385349 http://www.medworm.com/index.php?rid=5385348&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011737%26dopt%3DAbstract We report the case of a 35-year-old man with recurrent sinusitis whose radiologic workup revealed a lytic right sphenoid wing lesion with microcalcifications. He underwent gross-total resection of the lesion and the pathologic findings were diagnostic of ganglioneuroma. To the best of our knowledge, this is the first reported case of sphenoid wing GN. The nature and origin of this tumor are discussed, and the GN literature is reviewed. PMID: 22011737 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385348 Tue, 01 Nov 2011 04:00:00 +0100 5385348 http://www.medworm.com/index.php?rid=5385347&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011738%26dopt%3DAbstract Conclusion: Presence of dense, hypophysitis-like lymphocytic infiltration within pituitary adenoma tissue obtained by two consecutive operations may reflect an host-mediated immune reaction to tumor. This rare finding could be challenging in terms of differential diagnosis and follow-up course. PMID: 22011738 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385347 Tue, 01 Nov 2011 04:00:00 +0100 5385347 http://www.medworm.com/index.php?rid=5385346&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011739%26dopt%3DAbstract We report a case of a patient with multiple, intracranial superficial calcified tumorous lesions with focal amyloid deposition. On the basis of the first neuronavigated needle biopsy, the tumors were originally assessed as amyloidomas. Additional data was obtained from a second biopsy and supplementary neuroimaging information and the tumors were diagnosed as of vascular origin, probably cavernomas. The report exemplifies how only one diagnostic tool may sometimes be misleading in establishing a final diagnosis. The additional imaging may thoroughly enhance, supplement and improve the diagnostic process. PMID: 22011739 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385346 Tue, 01 Nov 2011 04:00:00 +0100 5385346 http://www.medworm.com/index.php?rid=5385345&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011740%26dopt%3DAbstract Conclusions: Awareness of this artifact would help making the appropriate pathological diagnosis for glioma. PMID: 22011740 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385345 Tue, 01 Nov 2011 04:00:00 +0100 5385345 http://www.medworm.com/index.php?rid=5385344&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011741%26dopt%3DAbstract Authors: Koutsopoulos AV, Mantadakis E, Katzilakis N, Lagoudaki ED, de Bree E, Stiakaki E, Kalmanti M PMID: 22011741 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5385344 Tue, 01 Nov 2011 04:00:00 +0100 5385344 http://www.medworm.com/index.php?rid=5287215&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955924%26dopt%3DAbstract Authors: Hainfellner JA PMID: 21955924 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5287215 Thu, 01 Sep 2011 04:00:00 +0100 5287215 http://www.medworm.com/index.php?rid=5287214&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955925%26dopt%3DAbstract Authors: Preusser M, Capper D, Hartmann C Abstract Isocitrate dehydrogenase 1 (IDH1) gene mutations, primarily of the R132H type, occur in approximately 60 - 90% of diffuse and anaplastic gliomas and secondary glioblastomas. IDH mutations in gliomas are associated with several clinically relevant parameters including patient age, histopathological diagnosis, combined 1p/19q deletion, TP53 mutation, MGMT promoter hypermethylation and patient survival. Therefore, testing of the IDH status is relevant for diagnostic and prognostic considerations in primary brain tumors. IDH status can be assessed by immunohistochemistry or DNA-based methods including gene sequencing in the routine setting. Here, we review the relevance of IDH testing in diffuse gliomas and present practical instructio... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5287214 Thu, 01 Sep 2011 04:00:00 +0100 5287214 http://www.medworm.com/index.php?rid=5287213&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955926%26dopt%3DAbstract We report on a 47-year-old woman in whom an anaplastic astrocytoma was resected in 2006. Postoperative radiation had to be interrupted because of a wound infection necessitating explantation of the infected bone flap and implantation of a titanium mesh. Subsequently, radiation therapy was completed and temozolomide was administered for 45 cycles. In the beginning of 2010 a new contrast enhancing mass was seen in the former tumor region. The mass was subtotally excised and showed no histomorphological similarity to the first lesion but represented a highly pleomorphic and mainly sarcomatoid differentiated malignant tumor. The lack of expression of GFAP or MAP-2 raised the question of a secondary malignancy, however, molecular genetic analysis of IDH1 and p53 revealed the same mutations in t... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5287213 Thu, 01 Sep 2011 04:00:00 +0100 5287213 http://www.medworm.com/index.php?rid=5287212&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955927%26dopt%3DAbstract In conclusion, both lesions are not desmoplastic infantile astrocytoma/ganglioglioma, fibrillary astrocytoma, or typical for pilocytic astrocytoma. Such extreme subpial spread with cysts is most unusual and may suggest a novel variant of infantile astrocytoma. PMID: 21955927 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5287212 Thu, 01 Sep 2011 04:00:00 +0100 5287212 http://www.medworm.com/index.php?rid=5287211&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955928%26dopt%3DAbstract This report shows that erlotinib and bevacizumab in combination may completely quench the transport of the essential amino acid methionine to a treatment refractory intracranial tumor bearing radiological and clinical characteristics of a chordoma. Further studies are necessary to establish this strategy as a treatment option for this indication. PMID: 21955928 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5287211 Thu, 01 Sep 2011 04:00:00 +0100 5287211 http://www.medworm.com/index.php?rid=5029357&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726500%26dopt%3DAbstract Authors: Hainfellner JA PMID: 21726500 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029357 Thu, 30 Jun 2011 23:00:00 +0100 5029357 http://www.medworm.com/index.php?rid=5029356&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726501%26dopt%3DAbstract Authors: Blümcke I, Mühlebner A FCDs are increasingly recognized in patients with drug-resistant epilepsies, and many patients benefit from tailored resection strategies. Yet, postsurgical seizure control cannot be sufficiently predicted and specification of FCD variants remains difficult during presurgical monitoring. The International League against Epilepsy (ILAE) has published a new consensus classification system for focal cortical dysplasias (FCDs). Based on a review of imaging data, electroclinical features and postsurgical seizure control correlation with neuropathological findings specify three clinico-pathological FCD subtypes: FCD Type I is characterized by aberrant radial (FCD Type Ia) or tangential lamination of the neocortex (FCD Type Ib) affecting one or multiple lobes... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029356 Thu, 30 Jun 2011 23:00:00 +0100 5029356 http://www.medworm.com/index.php?rid=5029355&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726502%26dopt%3DAbstract We report a rare and atypical case of a 31-year-old adult male with no evident congenital melanocytic lesions who presented with neurologic symptoms and was found to have leptomeningeal melanocytosis. The brain biopsy demonstrated a conspicuous but benign-appearing melanocytic infiltrate that was discordant with the severity of the patient's symptoms. Ultimately, the patient was suspected to represent a case of forme fruste neurocutaneous melanosis. Herein the relevant clinical and histopathologic features are discussed along with a brief review of the literature. PMID: 21726502 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029355 Thu, 30 Jun 2011 23:00:00 +0100 5029355 http://www.medworm.com/index.php?rid=5029354&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726503%26dopt%3DAbstract Authors: Liu L, Ross K, Xiong Z An autopsy was performed on a 26-year-old female with clinical history of hydrocephalus since birth. The dissection of the head and the histopathological examination demonstrated ossification of the arachnoid granulations and hydrocephalus. Arachnoid ossification usually involves the meninges covering spinal cord and rarely occurs within the cranial cavity. Intracranial arachnoid ossification is not reported causing any complications. To our knowledge, this is the first case of ossification of the arachnoid granulations complicated with hydrocephalus. PMID: 21726503 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029354 Thu, 30 Jun 2011 23:00:00 +0100 5029354 http://www.medworm.com/index.php?rid=5029353&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726504%26dopt%3DAbstract Conclusion: Our experience underscores the importance of adequate tissue sampling during biopsy for suspected glioma, and confirms the fact that active inflammatory demyelination may coexist with a high-grade glioma. Despite detailed study, the basis for the association remains elusive. PMID: 21726504 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029353 Thu, 30 Jun 2011 23:00:00 +0100 5029353 http://www.medworm.com/index.php?rid=5029352&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726505%26dopt%3DAbstract This report describes, for the first time, signet-ring cells in a prolactincell adenoma. Case history: The patient is a 46-year-old male who presented with severe headache and acute on chronic visual loss. Radiographic studies demonstrated a large cystic pituitary lesion with evidence of pituitary apoplexy. Laboratory values were consistent with a prolactin-cell adenoma. The patient underwent transsphenoidal resection of the prolactin-cell adenoma with significant post-operative improvement. Results: The tumor was composed of sheets of monomorphic round cells with conspicuous nuclei and granular cytoplasm, consistent with pituitary adenoma. Many cells had eccentric, often crescentic-shaped nuclei, imparting a signet-ring appearance and immunostaining was positive for prolactin, denoting an... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029352 Thu, 30 Jun 2011 23:00:00 +0100 5029352 http://www.medworm.com/index.php?rid=5029351&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726506%26dopt%3DAbstract Authors: Yan X, Marsh WR, Scheithauer BW Dysembryoplastic neuroepithelial tumor (DNET) is a benign glioneuronal neoplasm typically associated with intractable, partial complex seizures in children and young adults. The authors present a case in which a DNET in a 45-year-old male was accompanied by a so-called "calcifying pseudoneoplasm of the neural axis" (CPNA), a rare tumefactive lesion considered reactive in nature. An MRI scan of the brain revealed a right temporal lobe abnormality with characteristics of DNT but no apparent calcification. Histologically, it exhibited classic features of DNET and an overlying meningeal- based, partially ossified, chondrocalcific lesion morphologically characteristic of CPNA. The association of DNET and CPNA has not been previously reported. The lit... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029351 Thu, 30 Jun 2011 23:00:00 +0100 5029351 http://www.medworm.com/index.php?rid=5029350&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726507%26dopt%3DAbstract Authors: Alafaci C, Caffo M, Caruso G, Barresi V, Cutugno M, Salpietro FM, Tomasello F PMID: 21726507 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029350 Thu, 30 Jun 2011 23:00:00 +0100 5029350 http://www.medworm.com/index.php?rid=5029349&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21726508%26dopt%3DAbstract Authors: Wang YF, Piao YS, Lu DH, Liu J PMID: 21726508 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=5029349 Thu, 30 Jun 2011 23:00:00 +0100 5029349 http://www.medworm.com/index.php?rid=4830404&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545771%26dopt%3DAbstract Authors: Hainfellner JA PMID: 21545771 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830404 Sat, 30 Apr 2011 23:00:00 +0100 4830404 http://www.medworm.com/index.php?rid=4830403&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545772%26dopt%3DAbstract Conclusions: Muscle weakness was not obviously correlated to the number of repeats, but it is suggested that it might be linked to an increase of the transcription rate representing the ratio between mutated versus normal RT-PCR products. PMID: 21545772 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830403 Sat, 30 Apr 2011 23:00:00 +0100 4830403 http://www.medworm.com/index.php?rid=4830402&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545773%26dopt%3DAbstract Conclusion: LC degeneration, which may be macroscopically noted, often indicates synuclein and/or Alzheimer pathology among demented. When clinical information is scarce or inconsistent, a macroscopic assessment of the LC may facilitate focusing of the subsequent neuropathological investigation. Also, the semiquantitative scoring system is a reliable tool for histological assessment of LC degeneration. PMID: 21545773 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830402 Sat, 30 Apr 2011 23:00:00 +0100 4830402 http://www.medworm.com/index.php?rid=4830401&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545774%26dopt%3DAbstract Authors: Casula M, Steentjes K, Aronica E, van Geel BM, Troost D Post-polio syndrome (PPS) develops in approximately 30% of polio survivors several decades after the acute attack of paralytic poliomyelitis. Some of these patients develop post-poliomyelitis muscular atrophy (PPMA) which is characterized by a slowly progressive muscle weakness. Due to its clinicopathological features, investigators have often studied PPS and PPMA in association with amyotrophic lateral sclerosis (ALS), the underlying hypothesis being an increased risk of developing ALS from a prior acute paralytic poliomyelitis. Various studies, however, have indicated that de novo ALS cases in patients with prior acute paralytic poliomyelitis are rare. Herein, we describe a rare case of a 75-year-old woman who at post-m... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830401 Sat, 30 Apr 2011 23:00:00 +0100 4830401 http://www.medworm.com/index.php?rid=4830400&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545775%26dopt%3DAbstract We report 2 cases of angiolipoma involving sellar/suprasellar and right parasellar region in two female patients. On histopathology the lesion was composed of vascular component which was of cavernous type in one patient and of capillary caliber in the other with admixture of mature adipocytes. The MRI findings were distinctive as the lesion was predominantly iso-to-hypointense on T1W sequence, hyperintense on T2WI and FLAIR sequence. In addition, a few small hyperintense areas were noted on plain T1W images which may represent intralesional fat. One of the cases also showed lipid lactate peak on MR spectroscopy. To the best of our knowledge only 8 other cases of sellar, parasellar angiolipomas have been reported in indexed literature. MRI with fat suppression sequences should be routinely... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830400 Sat, 30 Apr 2011 23:00:00 +0100 4830400 http://www.medworm.com/index.php?rid=4830399&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545776%26dopt%3DAbstract Authors: Kirkbride M, Heitman K, Szallasi A PMID: 21545776 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830399 Sat, 30 Apr 2011 23:00:00 +0100 4830399 http://www.medworm.com/index.php?rid=4830398&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545777%26dopt%3DAbstract Authors: Rumana M, Kirmani A, Khursheed N, Naseer S, Rayees M, Khalil MB PMID: 21545777 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830398 Sat, 30 Apr 2011 23:00:00 +0100 4830398 http://www.medworm.com/index.php?rid=4830397&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545778%26dopt%3DAbstract Authors: Almubaslat M, Stone JC, Liu L, Xiong Z PMID: 21545778 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4830397 Sat, 30 Apr 2011 23:00:00 +0100 4830397 http://www.medworm.com/index.php?rid=4499164&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21329612%26dopt%3DAbstract Authors: Hainfellner JA PMID: 21329612 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4499164 Mon, 21 Feb 2011 00:01:00 +0100 4499164 http://www.medworm.com/index.php?rid=4499163&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21329613%26dopt%3DAbstract We present a practical approach to the FISH-based assessment of the 1p 19q status in oligodendroglial tumors, from commonly used locus-specific probes and technical protocols to the neuropathological interpretation of results. Thereby, we aim to facilitate the implementation of FISH-based 1p 19q testing for clinical purposes in standard neuropathology laboratories without special focus on brain tumor research. PMID: 21329613 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4499163 Mon, 21 Feb 2011 00:00:53 +0100 4499163 http://www.medworm.com/index.php?rid=4499162&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21329614%26dopt%3DAbstract Conclusion: The correlation between the neuropathological staging systems was suboptimal, and we conclude that the choice of staging system affects the evaluation of Alzheimer pathology, and hence the final diagnosis. PMID: 21329614 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4499162 Mon, 21 Feb 2011 00:00:40 +0100 4499162 http://www.medworm.com/index.php?rid=4499161&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21329615%26dopt%3DAbstract We present a case of a chordoid meningioma that presented in the third ventricle of a 63-year-old female. This represents only the second documented case of a third ventricular chordoid meningioma and the first case in an adult. The distinction from other chordoid neoplasms can be challenging, particularly chordoid gliomas, which classically occur in this location. Herein, we compare and contrast chordoid meningioma with chordoid glioma and provide a review of the relevant literature. PMID: 21329615 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4499161 Mon, 21 Feb 2011 00:00:33 +0100 4499161 http://www.medworm.com/index.php?rid=4499160&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21329616%26dopt%3DAbstract We report what appears to be the first case of a patient with aggressive primary intracerebral Hodgkin lymphoma with disease recurrence. PMID: 21329616 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4499160 Mon, 21 Feb 2011 00:00:26 +0100 4499160 http://www.medworm.com/index.php?rid=4499159&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21329617%26dopt%3DAbstract Authors: Gupta K, Salunke P, Kalra I, Vasishta RK The lipomatous differentiation occurring within neurocytoma has more frequently been reported in neurocytoma of cerebellar origin as case reports and short series. This case report describes the clinical, radiological, histopathological and ultrastructural findings of supratentorial central neurocytoma with lipomatous differentiation in a 45-year-old female. Magnetic resonance imaging (MRI) revealed an intraventricular lesion in the right trigone which was isointense on T1 and hyperintense on T2 weighted images. There were small cystic areas and it enhanced brilliantly and homogenously on contrast. The rare lipomatous differentiation occurring in neurocytoma in the supratentorial location lends it a distinct morphological profile and th... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4499159 Mon, 21 Feb 2011 00:00:20 +0100 4499159 http://www.medworm.com/index.php?rid=4499158&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21329618%26dopt%3DAbstract Authors: Gessi M, Fischer HP, Rösseler L, Urbach H, Pietsch T, van Landeghem FK PMID: 21329618 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4499158 Mon, 21 Feb 2011 00:00:14 +0100 4499158 http://www.medworm.com/index.php?rid=4289162&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176710%26dopt%3DAbstract Authors: Hainfellner JA PMID: 21176710 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289162 Sun, 26 Dec 2010 16:12:40 +0100 4289162 http://www.medworm.com/index.php?rid=4289161&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176711%26dopt%3DAbstract Authors: Kovacs GG, Wöhrer A, Ströbel T, Botond G, Attems J, Budka H Mutations in the microtubule-associated tau (MAPT) gene are associated clinically with frontotemporal dementia with or without supranuclear palsy, corticobasal syndrome or parkinsonism. Here we present clinical, neuropathological, genetic and biochemical data on a patient with an A152T variation in exon 7 of MAPT. A 63-year-old man presented with memory disturbance and later speech disorder, followed by progressive dementia and terminally myoclonus together with periodic sharp waves in EEG. Duration of illness was 5 years. Similar neuropsychiatric symptoms were reported in the patient's father. Neuropathological evaluation revealed neuronal loss mainly in the frontal and temporal cortices and substantia nigra. Abund... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289161 Sun, 26 Dec 2010 16:12:29 +0100 4289161 http://www.medworm.com/index.php?rid=4289160&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176712%26dopt%3DAbstract Conclusion: We conclude that, Churg-Strauss syndrome complicated frequently with polyneuropathy, and as remission depends on immunosuppressive therapy, it is important to recognize it in the early stage. The diagnosis of polyneuropathy is based on clinical and electrophysiologic studies, but precise histology, immunolohistochemistry and morphometric study of the peripheral nerve biopsy may be decisive in establishing the diagnosis. PMID: 21176712 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289160 Sun, 26 Dec 2010 16:12:23 +0100 4289160 http://www.medworm.com/index.php?rid=4289159&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176713%26dopt%3DAbstract Conclusion: Immunocytochemical staining of CSF cells with an antibody to annexin-1 is feasible. This may be helpful in further study of its role in the pathophysiology of inflammatory CNS diseases. The expression pattern seems to rather reflect the acuteness of the inflammatory process than specifying a certain underlying pathology. Although differences were observed between diverse disease groups, because of considerable overlap, a certain diagnosis of an individual case cannot be achieved. Thus, at present, we cannot recommend annexin-1 as a reliable surrogate marker of MS. PMID: 21176713 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289159 Sun, 26 Dec 2010 16:12:13 +0100 4289159 http://www.medworm.com/index.php?rid=4289158&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176714%26dopt%3DAbstract Conclusion: We report, to our knowledge, the second case of a calcifying pseudoneoplasm of the foramen magnum. We emphasize that these tumors are pathologically benign and do not require aggressive surgical treatment and suggest that asymptomatic cases can be followed radiologically. PMID: 21176714 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289158 Sun, 26 Dec 2010 16:12:06 +0100 4289158 http://www.medworm.com/index.php?rid=4289157&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176715%26dopt%3DAbstract We report two cases of cerebral coenurosis from India, the first in a 55-year-old male presenting with a large cystic lesion in the right parietooccipital region and the second occurring in a 36-year-old male involving the left temporal trigonal region, that radiologically closely mimicked hydatid cyst. Histopathologic examination revealed characteristic features of coenuri with multiple protoscolices invaginating into a large cyst lined by outer cuticular layer. Awareness of this rare parasitic infestation is important to discriminate from the more common hydatid and giant cysticercal cysts. PMID: 21176715 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289157 Sun, 26 Dec 2010 16:11:59 +0100 4289157 http://www.medworm.com/index.php?rid=4289156&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176716%26dopt%3DAbstract Conclusion: No significant correlation was found between EpoR expression and age, gender, WHO grade, number of mitosis or tumor recurrence. EpoR expression in CPT is in line with its expression in normal CP and with previous reports on EpoR expression in other glial neoplasms. Association of EpoR levels in CPT with survival, as known in astrocytic gliomas, remains to be determined. PMID: 21176716 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289156 Sun, 26 Dec 2010 16:11:51 +0100 4289156 http://www.medworm.com/index.php?rid=4289155&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176717%26dopt%3DAbstract Authors: Manfield J, Thorne L, Wilhelm T, Galloway M PMID: 21176717 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4289155 Sun, 26 Dec 2010 16:11:43 +0100 4289155 http://www.medworm.com/index.php?rid=4176258&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073836%26dopt%3DAbstract Authors: Hainfellner JA PMID: 21073836 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176258 Mon, 01 Nov 2010 00:00:00 +0100 4176258 http://www.medworm.com/index.php?rid=4176257&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073837%26dopt%3DAbstract Authors: Chen J, Hong D, Wang Z, Yuan Y Neutral lipid storage disease with myopathy (NLSDM) is a type of lipid storage myopathy arising due to a mutation in the PNPLA2 gene encoding an adipose triglyceride lipase responsible for the degradation of intracellular triglycerides. Herein, we report the cases of two siblings manifesting slowly progressive proximal and distal limb weakness in adulthood. One of the patients had dilated cardiomyopathy, hearing loss and short stature. Muscle specimens of the 2 patients revealed muscular dystrophic features with massive lipid droplets and numerous rimmed vacuoles in the fibers. A novel homozygous mutation IVS2+1G > A in the PNPLA2 gene was identified in the 2 cases, but not in the healthy familial individuals. The presence of massive lipid dro... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176257 Mon, 01 Nov 2010 00:00:00 +0100 4176257 http://www.medworm.com/index.php?rid=4176256&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073838%26dopt%3DAbstract Authors: Letournel F, Le Clec'h C, Croué A, Marcorelles P, Lavigne C, Pénisson-Besnier I Dermatomyositis was diagnosed on clinical and muscle histological criteria in a 42-year-old woman. Despite treatment, the patient complained of deterioration of her muscle condition. Since her symptoms were discordant with the rest of the data, muscle biopsy was performed and disclosed rod-bearing non-atrophic fibers as the unique and predominant pathological feature. Their significance is examined in this paper. PMID: 21073838 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176256 Mon, 01 Nov 2010 00:00:00 +0100 4176256 http://www.medworm.com/index.php?rid=4176255&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073839%26dopt%3DAbstract We report a 64-year-old female patient with a progressive gait disorder associated with cognitive decline since the age of 59. The patient had no mental retardation, cataract or chronic diarrhea. Her family reported increasing behavioral modifications 10 years previously. Clinical examination revealed a spastic paraplegia and bilateral xanthomas on the Achilles tendons. Cerebral magnetic resonance imaging (MRI) revealed diffuse hyperintense T2 abnormalities in the pyramidal tracts from the internal capsules to the cerebral peduncles also Technetium-99m-ECD brain SPECT showed a severe cerebellar hypoperfusion. Serum cholestanol analysis was 7 µmol/l (N). After 2 years, she was bedridden and died of aspiration pneumonia. The neuropathological study confirmed the CTX diagnosis and the sequen... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176255 Mon, 01 Nov 2010 00:00:00 +0100 4176255 http://www.medworm.com/index.php?rid=4176254&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073840%26dopt%3DAbstract Authors: Szekessy DP, Bamberg C, Blechschmidt C, Kaindl AM, Stoltenburg-Didinger G Focal and symmetric necrotic lesions of the brainstem are thought to result from fetal hypotension or cardiac arrest in the perinatal period and thus occur in the course of postnatal intensive care rather than in utero. Here, we report for the first time on brainstem necrosis in a preterm stillborn demonstrating that brainstem necrosis occurs already in utero. The preterm stillborn of 28 weeks gestation of a mother that suffered from HELLP-syndrome was severely affected by a fetal hydrops with bilateral pleural effusions and lung hypoplasia. Bilateral tegmental brainstem necrosis and thalamic lesions were detected. PMID: 21073840 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176254 Mon, 01 Nov 2010 00:00:00 +0100 4176254 http://www.medworm.com/index.php?rid=4176253&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073841%26dopt%3DAbstract Authors: Mellai M, Caldera V, Comino A, Fortunato M, Bernucci C, Schiffer D A case of peripheral PNET (PNET/ESFT) of the cranial vault is described. A 56-year-old woman showed a mass with a large cyst in the right temporal region, adherent to the meninges, which caused a left hemiparesis with headache and confusion. The mass was totally removed. The histological examination showed a dense proliferation of small elements, organized in lobules separated by reticulin septa. Many circumscribed necroses, vessels with a thick handcuff of reticulin, a diffuse mucous degeneration and abundant mitoses were present. The cells were positive for Vimentin and CD99. RT-PCR revealed the EWS/FLI1 fusion transcript of the t(11,22) (q24;q12) translocation. The patient presented is the oldest one of the ... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176253 Mon, 01 Nov 2010 00:00:00 +0100 4176253 http://www.medworm.com/index.php?rid=4176252&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073842%26dopt%3DAbstract Authors: Pantazis G, Psaras T, Krope K, von Coelln R, Fend F, Bock T, Schittenhelm J, Melms A, Meyermann R, Bornemann A Herein, we report the case of a 72-year-old male with an exceedingly rare manifestation of a low-grade lymphoma in the brain associated with light chain deposition disease (LCDD). The patient presented with epileptic seizures. Magnetic resonance imaging (MRI) of the brain revealed multiple hyperintense lesions in the right parietal lobe that were suspicious of vasculitis, low-grade glioma, or neurosarcoidosis. In the cerebrospinal fluid (CSF), but not in the serum, highly elevated IgG was found. A stereotactic biopsy of one cerebral lesion was performed. Histopathology revealed a low grade lymphoplasmacytic B-cell lymphoma with light chain deposition disease (LCDD). B... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176252 Mon, 01 Nov 2010 00:00:00 +0100 4176252 http://www.medworm.com/index.php?rid=4176251&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073843%26dopt%3DAbstract Conclusion: Frequent nuclear survivin expression implies the predominance of anti-apoptotic factors in pathogenesis of adult medulloblastomas. It may also be a potential therapeutic target for adult medulloblastomas. Although Blc-2 immunoreactivity was previously reported in approximately 30% in medulloblastomas, we have observed that it is rarely expressed in the present series of adult medulloblastomas. To our knowledge, this is the first study evaluating fascin expression in medulloblastomas. Its presence may be related to the neuronal differentiation. Mild-to-moderate cytoplasmic c-KIT immunoreactivity without membranous staining in adult medulloblastomas may support the previous studies reporting low level of c-KIT protein expression with lack of activating mutations in medulloblastom... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176251 Mon, 01 Nov 2010 00:00:00 +0100 4176251 http://www.medworm.com/index.php?rid=4176250&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21073844%26dopt%3DAbstract Conclusion: The data suggest significant degeneration of cortical white matter in vCJD; the vacuolation being related to neuronal loss in the lower cortical laminae of adjacent grey matter, PrPsc deposits the result of leakage from damaged axons, and gliosis a reaction to these changes. PMID: 21073844 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4176250 Mon, 01 Nov 2010 00:00:00 +0100 4176250 http://www.medworm.com/index.php?rid=4002481&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860889%26dopt%3DAbstract Authors: Hainfellner JA PMID: 20860889 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002481 Tue, 31 Aug 2010 23:00:00 +0100 4002481 http://www.medworm.com/index.php?rid=4002480&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860890%26dopt%3DAbstract Authors: Kovacs GG, Budka H Definitive diagnosis of neurodegenerative diseases (NDDs) relies on the neuropathological evaluation. NDDs are defined as disorders with progressive loss of neurons showing distinct anatomical distribution, and accordingly different clinical phenotypes. Recent research has identified a spectrum of immunohistochemically detectable proteins deposited in the central nervous system which serve as a basis for protein-based disease classification. Accordingly, diagnostic criteria and disease staging have been updated. Furthermore, it has become evident that there is considerable overlap between deposited proteins and pathologies. This review summarizes recent achievements in neuropathological diagnosis and classification of NDDs and recommends approaches to be use... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002480 Tue, 31 Aug 2010 23:00:00 +0100 4002480 http://www.medworm.com/index.php?rid=4002479&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860891%26dopt%3DAbstract Authors: Scheithauer BW, Aker AT, Ketterling RP, Carlson AW, Knudson RA, Tyler M Astroblastoma is a distinctive brain tumor when its histologic features occur in pure form. More often, the tumor pattern is seen to emerge in infiltrative astrocytic tumors. The former are rare. Astroblastoma as a de novo component of gliosarcoma has not previously been described. Furthermore, astroblastoma has only once been reported to occur in the setting of neurofibromatosis Type I (NF1), a condition more often associated with pilocytic and diffuse or infiltrative astrocytic tumors. Herein, we describe a unique case of anaplastic de novo astroblastoma-sarcoma, in essence a variant of gliosarcoma, occurring in a 50-year-old female with documented NF1. Genetic study (fluorescence in situ hybridization) ... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002479 Tue, 31 Aug 2010 23:00:00 +0100 4002479 http://www.medworm.com/index.php?rid=4002478&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860892%26dopt%3DAbstract We report the case of an 18-year-old woman with an intradural retroclival retrosellar glioneuronal heterotopion. At the time of surgery, a well circumscribed pale-tan mass was identified posterior to and distinct from the posterior pituitary. Pathologic examination showed disorganized, non-neoplastic glial tissue characteristic of glioneuronal heterotopia. To our knowledge, this is the first report of such a lesion in this location. PMID: 20860892 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002478 Tue, 31 Aug 2010 23:00:00 +0100 4002478 http://www.medworm.com/index.php?rid=4002477&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860893%26dopt%3DAbstract CONCLUSION: The biologic basis for the association of SFT and astrocytoma is unknown. The complex lesion differs substantially from WHO Grade IV gliosarcoma and from gliofibroma, lesions in which the disparate elements are linked by metaplasia. Indeed, it may represent a collision tumor. Lastly, induction of the glioma by the solitary fibrous tumor, a mechanism invoked to explain the poorly understood "sarcoglioma," deserves consideration. PMID: 20860893 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002477 Tue, 31 Aug 2010 23:00:00 +0100 4002477 http://www.medworm.com/index.php?rid=4002476&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860894%26dopt%3DAbstract We present two unusual cases of rhabdoid meningiomas diagnosed as a primary intracranial lesion in adults that were associated with extensive necrosis and an aggressive clinical course. On histological examination, the majority of the tumor mass was composed of necrotic tissue with focal clusters of neoplastic cells, often localized around blood vessels. Most tumor cells exhibited typical rhabdoid morphology with large, vesicular, often eccentrically located nuclei with distinct nucleoli and abundant cytoplasm containing eosinophilic hyaline inclusions. Classical meningothelial features with focal whorl formation were scarce and seen only in one case; in the second case the tumor was entirely rhabdoid. The differential diagnosis with atypical teratoid/rhabdoid tumors (AT/RTs) and other neo... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002476 Tue, 31 Aug 2010 23:00:00 +0100 4002476 http://www.medworm.com/index.php?rid=4002475&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860895%26dopt%3DAbstract In conclusion, our findings suggest that NGAL expression is restricted to high grade gliomas among primary brain tumors, and that brain metastases do not express this protein. Considering the correlation between NGAL expression in tumors and its urinary levels, if our observations will be further validated, NGAL urinary detection might be used as an additional tool in the pre-surgical definition of brain lesions involving difficult differential diagnosis. PMID: 20860895 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002475 Tue, 31 Aug 2010 23:00:00 +0100 4002475 http://www.medworm.com/index.php?rid=4002474&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860896%26dopt%3DAbstract We present the case of a 69-year old patient with a contrast enhancing, partially cystic lesion of the right temporal lobe, involving the ventricle and extending into the occipital lobe. The resected tumor showed histological features of a glioblastoma with granular cell astrocytoma features, lacking amplification of the EGFR gene region and IDH1R132H mutation. Literature review of 59 cases showed a 12-month overall survival of 11.7% for high-grade and 40% for low-grade granular cell astrocytomas. In 35% more than one cerebral lobe was affected. These extended mass effects may explain the worse prognosis despite the relatively bland histology of the granular cell component. PMID: 20860896 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002474 Tue, 31 Aug 2010 23:00:00 +0100 4002474 http://www.medworm.com/index.php?rid=4002473&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860897%26dopt%3DAbstract Authors: Jaiswal S, Agrawal V, Vij M, Sahu RN, Jaiswal AK, Behari S A 54-year-old male presented with the history of headache and vomiting. MRI of the head showed right posterior temporal mass which was surgically excised. Histopathological examination revealed features of glioblastoma with pigmented cells. The pigment was demonstrated to be melanin which was confirmed by special stains and immunohistochemistry. This is the first description of glioblastoma with melanotic differentiation reported in the literature. The relevant literature is briefly reviewed. PMID: 20860897 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002473 Tue, 31 Aug 2010 23:00:00 +0100 4002473 http://www.medworm.com/index.php?rid=4002472&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860898%26dopt%3DAbstract DISCUSSION: We found 9 cases of ISCM of MM in the literature, 5 of which were located in the cervical cord, 3 in the thoracic cord, and 1 in the lumbar cord. One difference between the findings noted in the literature and those in the present case involved the cross-sectional location of metastases in the spinal cord. In the present case, it appeared that postoperative management for the left buccal melanoma, which did not include adjuvant therapy, affected the postoperative clinical course. The prognosis was also affected by overlooking of ISCM. The brain metastases in the present case induced deterioration of her neurological symptoms rapid enough that the possibility of ISCM was not considered. On evaluation of tumor spread from MM, it is important to take into account not only intracra... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=4002472 Tue, 31 Aug 2010 23:00:00 +0100 4002472 http://www.medworm.com/index.php?rid=3697279&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569669%26dopt%3DAbstract Authors: Hainfellner J PMID: 20569669 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697279 Sat, 26 Jun 2010 05:42:35 +0100 3697279 http://www.medworm.com/index.php?rid=3697278&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569670%26dopt%3DAbstract Authors: Uro-Coste E, Russano de Paiva G, Guilbeau-Frugier C, Sastre N, Ousset PJ, da Silva NA, Lavialle-Guillotreau V, Vellas B, Delisle MB After the interruption of the international multicenter Phase 2 clinical trial with active immunotherapy based on synthetic Abeta42 (AN1792), few reports about the neuropathological findings in those patients and those from the Phase 1 clinical trial were published. These reports described some pathological similarities among the patients such as a reduction in the burden of amyloid plaques, the reactions of microglia/macrophages and the persistence of neurofibrillary tangles and neuropil threads. In addition, a lymphocytic inflammatory infiltrate as well as white matter lesions were present in some cases with meningoencephalitis. In both animal m... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697278 Sat, 26 Jun 2010 05:42:32 +0100 3697278 http://www.medworm.com/index.php?rid=3697277&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569671%26dopt%3DAbstract Authors: Foreid H, Barroso C, Evangelista T, Campos A, Pimentel J Intracerebral amyloidoma (ICA) is a type of monoclonal immunoglobulin deposition disease (MIDD) which is accompanied by an overexpression and fibrillary assembly of monoclonal light chains, ultimately leading to nodular deposits of light chains in the form of amyloid light chain (AL-amyloid). The diagnosis is made by the histological demonstration of intracerebral masses harboring the classical staining and birefringence features of amyloid. We aim to report a case of ICA and review histological features of previous cases. A 51-year-old man with epilepsy and cognitive decline was admitted for epileptic seizures. A brain magnetic resonance imaging (MRI) disclosed periventricular enhancing lesions, hypointense on T1 and he... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697277 Sat, 26 Jun 2010 05:42:29 +0100 3697277 http://www.medworm.com/index.php?rid=3697276&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569672%26dopt%3DAbstract We report a case in a 48 year old male with complex partial seizures who had a right temporobasal calcified lesion that clinically and radiologically mimicked an oligodendroglioma. Histopathology revealed a large necrotic lobulated mass with admixture of chondromyxoid zones, nodular fibrovascular stroma, metaplastic calcification and ossification in varying proportions. PMID: 20569672 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697276 Sat, 26 Jun 2010 05:42:26 +0100 3697276 http://www.medworm.com/index.php?rid=3697275&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569673%26dopt%3DAbstract Conclusion: The origin of paragangliomas of the CNS and especially of the filum terminale is still unclear. If no complete surgical resection can be achieved, molecular cytogenetic analysis is of additional value to prognostification of paragangliomas of the filum terminale. PMID: 20569673 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697275 Sat, 26 Jun 2010 05:42:22 +0100 3697275 http://www.medworm.com/index.php?rid=3697274&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569674%26dopt%3DAbstract Authors: Mihaljevic B, Sternic N, Skender Gazibara M, Sretenovic A, Antic D, Terzic T, Kostic V Intravascular large B-cell lymphoma (IVL) is a rare form of diffuse large B cell lymphoma (DBCL) frequently presenting with skin and/or central nervous system (CNS) involvement. IVL involves CNS in 75 - 85% of patients and neurological symptoms include sensory and motor deficits or neuropathies, meningoradiculitis, paresthesia, hypostenia, aphasia, dysarthria, hemiparesis, seizures, transient visual loss, vertigo and impaired cognitive function. Neuroimaging discloses CNS involvement only in half of patients with neurological symptoms because there are no pathognomonic neuroradiological findings for IVL; ischemic foci are the most common presentation pattern and therefore vasculitis is the m... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697274 Sat, 26 Jun 2010 05:42:20 +0100 3697274 http://www.medworm.com/index.php?rid=3697273&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569675%26dopt%3DAbstract Conclusions: Our study reports the low frequency of PIK3CA and B-RAF mutations in astrocytomas, despite the presence of activated ERK and AKT proteins. Moreover, the correlation of pERK nuclear and pAKT cytoplasmic expression with tumor grade suggests the possible crucial role of the activation of these proteins in human gliomagenesis. PMID: 20569675 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697273 Sat, 26 Jun 2010 05:42:16 +0100 3697273 http://www.medworm.com/index.php?rid=3697272&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569676%26dopt%3DAbstract Authors: Adam J, Polivka M, Kaci R, Godfraind C, Gray F Distinctive hyaline inclusion bodies in the cytoplasm of neocortical astrocytes were observed in surgical resection specimens of a frontal epileptic focus, in 2 patients aged 16 and 10 who had suffered intractable partial seizures since the age of 2 years. One case had minimal neurological impairment and no brain malformation on MRI and recovered completely following surgery. The second case had mental retardation and surgery reduced the frequency and generalization of seizures. In both cases, the astrocytic inclusions were strongly eosinophilic, hyaline and refractile. They were PAS negative. Electron microscopy in the first case, confirmed their granular osmiophilic structure. By immunohistochemistry, the inclusions were strongl... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697272 Sat, 26 Jun 2010 05:42:13 +0100 3697272 http://www.medworm.com/index.php?rid=3697271&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569677%26dopt%3DAbstract Conclusions: Immunolabeling of dystrobrevin could be a useful marker in the diagnostic of neuromuscular diseases. PMID: 20569677 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697271 Sat, 26 Jun 2010 05:42:09 +0100 3697271 http://www.medworm.com/index.php?rid=3697270&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20569678%26dopt%3DAbstract Conclusion: Tubuloreticular inclusions may be found in the muscle endothelial cells of patients with a clinical and pathological diagnosis of IBM. PMID: 20569678 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3697270 Sat, 26 Jun 2010 05:42:06 +0100 3697270 http://www.medworm.com/index.php?rid=3519687&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423683%26dopt%3DAbstract Authors: Hainfellner J PMID: 20423683 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519687 Fri, 30 Apr 2010 16:52:37 +0100 3519687 http://www.medworm.com/index.php?rid=3519686&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423684%26dopt%3DAbstract We report a case of colloid cyst of the third ventricle arising in association with a remnant which we believe corresponds to the paraphysis cerebri in man. PMID: 20423684 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519686 Fri, 30 Apr 2010 16:52:34 +0100 3519686 http://www.medworm.com/index.php?rid=3519685&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423685%26dopt%3DAbstract Conclusion: To date less than 30 bona fide examples have been described and typically present symptoms due to mass effects such as visual disturbances, hypopituitarism as well as interference with hypothalamic dopamine release, resulting in subsequent hyperprolactinemia accompanied by decreased libido and amenorrhea in females. These neoplasms represent an important differential diagnosis with respect to suprasellar lesions and a clinical and neuropathological challenge. PMID: 20423685 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519685 Fri, 30 Apr 2010 16:52:31 +0100 3519685 http://www.medworm.com/index.php?rid=3519684&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423686%26dopt%3DAbstract Authors: Furtado A, Arantes M, Silva R, Romao H, Resende M, Honavar M Two new cases of extraventricular neurocytoma are reported. The first concerns an 18-year-old female with a left frontal lobe lesion and the second occurred in a 54-year-old female in the thoracic spinal cord. The first patient is free of disease after 18 months of follow up. The second patient is stable after 16 months of follow up. Both were operated - total excision in Case 1 and partial resection in Case 2. The latter underwent adjuvant radiotherapy due to atypical histological features. Cases of extraventricular neurocytoma are reviewed. Differences and similarities between extraventricular and central neurocytoma are outlined. PMID: 20423686 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519684 Fri, 30 Apr 2010 16:52:28 +0100 3519684 http://www.medworm.com/index.php?rid=3519683&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423687%26dopt%3DAbstract We report a case of a 58-years-old man with a 31-months history of oligodendroglioma presenting with fatigue and anemia. A bone marrow biopsy demonstrated massive localization of oligodendroglioma which was confirmed by in situ hybridization for the 1p/19q deletion. In addition we studied data from PALGA, the nationwide network and registry of histo- and cytopathology in the Netherlands and found an incidence of approximately 2 in 1,000 for metastasis of oligodendroglioma outside the central nervous system. PMID: 20423687 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519683 Fri, 30 Apr 2010 16:52:25 +0100 3519683 http://www.medworm.com/index.php?rid=3519682&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423688%26dopt%3DAbstract Authors: Mesfin FB, Deshaies EM, Patel R, Weaver S, Spurgas P, Popp AJ A 51-year-old right-handed woman initially presented with generalized tonic-clonic seizures. MRI showed abnormal signal hyperintensity of the right temporal lobe that was thought to be consistent with ischemic stroke. Three years later, she developed an intensely enhancing centrally necrotic tumor in the right temporal-parietal lobes. A craniotomy was performed with gross total resection of the tumor followed by chemotherapy and radiation treatments. Histological examination demonstrated a gliosarcoma. A year later, she had a recurrence of the intra-axial gliosarcoma requiring a second craniotomy for tumor resection and placement of Gliadel wafers. Postoperatively, she developed plural effusions. A pulmonary workup ... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519682 Fri, 30 Apr 2010 16:52:22 +0100 3519682 http://www.medworm.com/index.php?rid=3519681&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423689%26dopt%3DAbstract Conclusion: Although rare, inflammatory pseudotumor of central nervous system is important in the differential diagnosis of the tumor-like intracranial lesions. We discuss the etiopathogenetic, diagnostic and therapeutic issues related to this entity, and review the literature. PMID: 20423689 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519681 Fri, 30 Apr 2010 16:52:19 +0100 3519681 http://www.medworm.com/index.php?rid=3519680&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423690%26dopt%3DAbstract Conclusion: If isolated neurosarcoidosis is diagnosed early it will save a costly and invasive work-up. Radiographic and laboratory studies may aid in diagnosis but no studies are pathognomonic. Neurosarcoidosis is diagnosed by a combination of imaging, diagnostic tests, and good clinical suspicion. PMID: 20423690 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519680 Fri, 30 Apr 2010 16:52:16 +0100 3519680 http://www.medworm.com/index.php?rid=3519679&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423691%26dopt%3DAbstract Conclusion: The exact mechanism causing a pregnancy-associated increase in the size of meningiomas and the amount of peritumoral edema has not been clearly elucidated. As for this case of chordoid meningioma associated with pregnancy, we think mucin accumulation in tumor could be involved in an increase in the tumor size while delivery procedures with the common anaesthetic and sedative drugs may also have enhanced the peritumoral edema by causing a relative decrease in the cerebral blood flow. PMID: 20423691 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519679 Fri, 30 Apr 2010 16:52:12 +0100 3519679 http://www.medworm.com/index.php?rid=3519678&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423692%26dopt%3DAbstract Conclusion: Considering our cases in context with so far published literature, we conclude that intradural chordomas are rare and in this location usually have a better prognosis compared to classical intraosseous chordomas. PMID: 20423692 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519678 Fri, 30 Apr 2010 16:52:09 +0100 3519678 http://www.medworm.com/index.php?rid=3519677&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20423693%26dopt%3DAbstract Authors: Schiffer D The history of Italian Neuropathology begins in the XIX century with Lombroso with his studies of criminal and prostitutes, inspired by the positivism of the era, and on the brain of epileptic patients. It reached its peak at the beginning of XX century with Camillo Golgi, Nobel laureate for his impregnation of neurons and the theory of the diffuse neuronal net. Neuropathology was then cultivated in Asylums and Universities where the main subject of interest were dementias and degenerative diseases, followed by vascular and inflammatory diseases. Some Laboratories arose in the country, especially in neurological institutes and some people later began to emigrate, especially to France and Germany and then to USA in order to improve their Neuropathology. Starting in t... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3519677 Fri, 30 Apr 2010 16:52:06 +0100 3519677 http://www.medworm.com/index.php?rid=3307541&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175952%26dopt%3DAbstract Authors: Hainfellner J PMID: 20175952 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307541 Fri, 26 Feb 2010 00:22:41 +0100 3307541 http://www.medworm.com/index.php?rid=3307540&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175953%26dopt%3DAbstract Authors: Vital C, Lagueny A, Mercie P, Viallard JF, Delabrousse-Mayoux JP, Vital A Objective: Most cases of familial amyloid polyneuropathy are identified by molecular genetic analysis of the transthyretin (TTR) gene. However, it is not uncommon to find unexpected amyloid deposits marked by the anti-TTR serum in the endoneurium of aged patients. Light chain amyloid deposits may also be found in the endoneurium. During these past 5 years, we studied the muscle and nerve biopsies from 6 patients which revealed amyloid deposits. There were 2 patients with an idiopathic polyneuropathy and 4 with monoclonal gammopathy (MG). Methods: In each case, specimens from the superficial peroneal nerve and peroneus brevis muscle were taken by the same cutaneous incision. Results: Amyloid deposits were... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307540 Fri, 26 Feb 2010 00:22:37 +0100 3307540 http://www.medworm.com/index.php?rid=3307539&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175954%26dopt%3DAbstract Conclusions: These findings both in the local anatomy and sciatic nerve correspond to lesions that are expected in PS. Nevertheless, since this was a cadaveric study, unassociated to a certain pain patient's history, results should be considered and interpreted as an indication of a sciatic nerve injury in PS. PMID: 20175954 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307539 Fri, 26 Feb 2010 00:22:32 +0100 3307539 http://www.medworm.com/index.php?rid=3307538&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175955%26dopt%3DAbstract We present a comprehensive report of two siblings with hereditary inclusion body myopathy (HIBM). The clinical features and histological characteristics of the muscle biopsies showed the typical pattern of predominantly distal vacuolar myopathy with quadriceps sparing. This was confirmed by muscle MRI. PNA lectin staining showed an increased signal at the sarcolemma in patient muscle sections compared to control muscle, indicating reduced sialylation of glycoconjugates. Mutation analysis revealed compound heterozygous mutations in the GNE gene, encoding the key enzyme in sialic acid synthesis UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase: a missense mutation (c.2086G > A; p.V696M) previously described in HIBM patients of Indian origin, and a novel frame shift mutation (... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307538 Fri, 26 Feb 2010 00:22:27 +0100 3307538 http://www.medworm.com/index.php?rid=3307537&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175956%26dopt%3DAbstract Authors: Fidzianska A, Niebrój-Dobosz I, Madej-Pilarczyk A, Duong NT, Wehnert M The study demonstrates a 12-year-old patient with progressive proximal muscle weakness, joint contractures, rigidity of the neck, and absence of emerin and lamin A in the muscle nuclei, which is caused by intronic mutation IVS3-27del18 (c.266-27del18) in the emerin gene. The most surprising finding was the appearance of IBM-like inclusions in euchromatin, as well as aberrant nuclei. It may be speculated that altered expression of the emerin-lamin complex and modification of the nuclear matrix leads to formation of tubulofilamentous structures in the presented case. PMID: 20175956 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307537 Fri, 26 Feb 2010 00:22:23 +0100 3307537 http://www.medworm.com/index.php?rid=3307536&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175957%26dopt%3DAbstract Conclusions: This is the first case in which the accumulation of amiodarone in the brain was morphologically observed. Amiodarone accumulation in the brain may play a role in neurotoxicity inducing parkinsonism. PMID: 20175957 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307536 Fri, 26 Feb 2010 00:22:20 +0100 3307536 http://www.medworm.com/index.php?rid=3307535&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175958%26dopt%3DAbstract Conclusions: Both giant cell and non-giant cell glioblastomas frequently show CD34 expression by neoplastic cells, which may in some cases be strong and diffuse. Strong widespread staining of neoplastic cells for CD34 was more frequent in giant cell than non-giant cell glioblastomas, however this difference was not statistically significant. CD34 staining in isolation is unlikely to be of assistance in differentiating between giant cell glioblastoma and pleomorphic xanthoastrocytomas with anaplastic features or anaplastic gangliogliomas. PMID: 20175958 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307535 Fri, 26 Feb 2010 00:22:17 +0100 3307535 http://www.medworm.com/index.php?rid=3307534&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175959%26dopt%3DAbstract Conclusion: Perineurioma, a tumor affecting soft tissue, and presumably nerve-unassociated, may affect bone. No prior entirely osseous examples have been reported. This tumor expands the differential diagnosis of spindle cell tumors of bone. PMID: 20175959 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307534 Fri, 26 Feb 2010 00:22:14 +0100 3307534 http://www.medworm.com/index.php?rid=3307533&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175960%26dopt%3DAbstract Authors: Makhdoomi R, Nayil K, Santosh V, Kumar S Paragangliomas are unique neuroendocrine neoplasms arising in specialized neural crest cells and may be adrenal or extra-adrenal. Paragangliomas have been described in various unusual locations, e.g., urinary bladder, prostate, cauda equina, larynx, sellar region, thyroid gland and nasal cavity. Orbital paragangliomas are very rare and peculiar in histogenesis as the orbit is a site in which the existence of normal paraganglia is not well-documented in humans. We hereby report a case of an orbital paraganglioma in a 70-year-old female patient, the oldest patient reported so far. PMID: 20175960 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307533 Fri, 26 Feb 2010 00:22:11 +0100 3307533 http://www.medworm.com/index.php?rid=3307532&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175961%26dopt%3DAbstract We report an unusual case of a patient with a sphenoid wing meningioma that after a few years of static radiological appearance presented with sudden deterioration following rapid growth of tumor with intratumoral infarct. The patient underwent surgery and malignant melanoma deposits within the meningioma were demonstrated on histopathological examination. She had a history of a malignant melanoma (MM) excised from the left forearm 10 months ago with no evidence of recurrence. Although metastasis to meningioma has been widely reported, this is only the second report where the primary tumor is MM. In addition, to the best of our knowledge, intratumoral hypodensity from metastasis is unusual. The tumor-to-tumor phenomenon is discussed and the literature is reviewed. PMID: 20175961 [PubMe... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307532 Fri, 26 Feb 2010 00:22:08 +0100 3307532 http://www.medworm.com/index.php?rid=3307531&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20175962%26dopt%3DAbstract Conclusion: The immunohistochemical study of expression of VEGF, EGFR, TGFβ2, TGFβ3, PDGF and p53 in all low-grade (Grade II) brain gliomas at the first operation may help to differentiate cases with slower evolution and longer survival from those with higher potential of anaplastic transformation. PMID: 20175962 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3307531 Fri, 26 Feb 2010 00:22:05 +0100 3307531 http://www.medworm.com/index.php?rid=3134088&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040325%26dopt%3DAbstract Authors: Hainfellner J PMID: 20040325 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134088 Fri, 01 Jan 2010 00:00:00 +0100 3134088 http://www.medworm.com/index.php?rid=3134087&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040326%26dopt%3DAbstract Conclusions: Similar to the ten previously reported cases of malignant transformation in craniopharyngioma, the present case occurred after radiation therapy. p53 protein overexpression was also observed in the earlier cases of malignant craniopharyngioma as well as in the present case (6/6 cases). We concluded that radiation therapy and p53 mutations could be involved in malignant transformation in craniopharyngioma. PMID: 20040326 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134087 Fri, 01 Jan 2010 00:00:00 +0100 3134087 http://www.medworm.com/index.php?rid=3134086&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040327%26dopt%3DAbstract Conclusions: The intracranial extension of salivary gland tumors is a very rare event. An aggressive surgical resection followed by radiotherapy is justified in cases with significant intracranial mass lesions and scarce bone and dural involvement. PMID: 20040327 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134086 Fri, 01 Jan 2010 00:00:00 +0100 3134086 http://www.medworm.com/index.php?rid=3134085&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040328%26dopt%3DAbstract Authors: Sav A, Scheithauer BW, Mazzola CA, Ketterling SR, Thompson SJ, Reilly MH, Herein, we report an unusual choroid plexus carcinoma with extensive oncocytic transformation. A 13-month-old girl presented with acute lethargy which quickly progressed to coma. A CT scan of the head revealed impending herniation due to hemorrhage within an intracranial tumor. An MRI scan showed a large, partly cystic and highly vascular left lateral ventricular mass. A near total resection was achieved. Microsections revealed a WHO Grade III choroid plexus carcinoma with extensive oncocyti c transformation. A minor portion of the moderately to poorly differentiated tumor exhibited classical microscopic features of choroid plexus carcinoma, including marked nuclear atypia, brisk mitotic activity (78/10... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134085 Fri, 01 Jan 2010 00:00:00 +0100 3134085 http://www.medworm.com/index.php?rid=3134084&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040329%26dopt%3DAbstract Conclusions: Intracranial angioleiomyoma is a benign soft tissue tumor with excellent prognosis. Early diagnosis of this tumor is difficult. PMID: 20040329 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134084 Fri, 01 Jan 2010 00:00:00 +0100 3134084 http://www.medworm.com/index.php?rid=3134083&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040330%26dopt%3DAbstract Authors: Rumana M, Kirmani A, Khursheed N, Besina S, Khalil M, Lymphocytic hypophysitis (LYH) is a rare autoimmune inflammatory disorder of the pituitary gland usually affecting young women, often in pregnancy or post partum period. It is rare in non-pregnant females and in men. Patients present with symptoms of an expanding pituitary mass and/or varying degrees of pituitary dysfunction. We, hereby report a case of lymphocytic hypophysitis in a 28-year-old non-pregnant female who presented with clinical and radiological features of a pituitary tumor with normal pituitary hormones which on histopathological examination revealed features of lymphocytic hypophysitis. The case is presented here for its rarity and its unique presentation as an expanding pituitary mass with normal pituitary... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134083 Fri, 01 Jan 2010 00:00:00 +0100 3134083 http://www.medworm.com/index.php?rid=3134082&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040331%26dopt%3DAbstract Authors: Marucci G, Rubboli G, Giulioni M, Drug-resistant chronic temporal lobe epilepsy is the most common type of epilepsy that undergoes surgical treatment. To verify if dentate gyrus alterations may play a role in patients with mesial temporal sclerosis (MTS), 14 patients, submitted to epilepsy surgery, were selected. Only cases with MTS alone were included. Granule cell dispersion (GCD) was observed in 7 cases (50%). A statistically significant correlation between GCD and the mean number of seizures/month was evidenced. The percentage of patients who did not achieve seizure relief (i.e. they were not in Engel class 1A) was 57.14% in patients without GCD, whereas that percentage dropped to 14.29% in patients with GCD. The association between a more favorable postsurgical epileptog... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134082 Fri, 01 Jan 2010 00:00:00 +0100 3134082 http://www.medworm.com/index.php?rid=3134081&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040332%26dopt%3DAbstract We report morphological findings of this rare disorder and compare the findings with earlier two reports. PMID: 20040332 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134081 Fri, 01 Jan 2010 00:00:00 +0100 3134081 http://www.medworm.com/index.php?rid=3134080&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20040333%26dopt%3DAbstract Authors: Hainfellner JA, Heinzl H, Brain tumors comprise a large spectrum of rare malignancies in children and adults that are often associated with severe neurological symptoms and fatal outcome. Neuropathological tumor typing provides both prognostic and predictive tissue information which is the basis for optimal postoperative patient management and therapy. Molecular biomarkers may extend and refine prognostic and predictive information in a brain tumor case, providing more individualized and optimized treatment options. In the recent past a few neuropathological brain tumor biomarkers have translated smoothly into clinical use whereas many candidates show protracted translation. We investigated the causes of protracted translation of candidate brain tumor biomarkers. Considering ... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3134080 Fri, 01 Jan 2010 00:00:00 +0100 3134080 http://www.medworm.com/index.php?rid=3013352&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919813%26dopt%3DAbstract Authors: Hainfellner JW PMID: 19919813 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013352 Sun, 01 Nov 2009 00:00:00 +0100 3013352 http://www.medworm.com/index.php?rid=3013351&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919814%26dopt%3DAbstract Conclusion: The RyR1 Thr2206Met mutation is one of the most frequent mutations in the European MH population but carriers are normally healthy. In this study we could demonstrate that the MH causative Thr2206Met mutation may also be associated both with clinical symptoms of a mild myopathy and histopathological changes in the oxidative inter myofibrillar network. PMID: 19919814 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013351 Sun, 01 Nov 2009 00:00:00 +0100 3013351 http://www.medworm.com/index.php?rid=3013350&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919815%26dopt%3DAbstract Conclusion: Fusarium is resistant to standard antifungal therapies; the increasing use of antifungal medications - as either treatment or prophylaxis - may shift more infections toward unusual species such as Fusarium. PMID: 19919815 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013350 Sun, 01 Nov 2009 00:00:00 +0100 3013350 http://www.medworm.com/index.php?rid=3013349&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919816%26dopt%3DAbstract Authors: Kobayashi Z, Tsuchiya K, Yokota O, Haga C, Arai T, Akiyama H, Kotera M, Mizusawa H, The patient was a 17-year-old man, who developed Japanese encephalitis in the autumn of 1990 in Japan. He was admitted to our hospital 4 days after onset because of consciousness disturbance. On admission, neurological examination demonstrated left hemiparesis, neck stiffness, and Kernig's sign. He developed generalized tonico-clonic seizure, and required a respirator on the next day of admission. Brain CT 10 days after onset demonstrated hypodensities in the right hippocampus, and the CT obtained 39 days after onset showed whole brain atrophy and hypodensities in the anterior portion of the bilateral thalamus. He died 40 days after onset. Postmortem examination demonstrated perivascular and p... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013349 Sun, 01 Nov 2009 00:00:00 +0100 3013349 http://www.medworm.com/index.php?rid=3013348&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919817%26dopt%3DAbstract Conclusion: In contrast to the initially promising laboratory data gathered in pituitary cell line experiments and nude mice models, our experimental data obtained in primary human ACTH-expressing pituitary adenoma cell cultures as well as our clinical experience with a long-term rosiglitazone trial in approved antidiabetic doses support the recently reported disappointing reports on acute or short-term medical treatment of ACTH-hypersecretion with PPAR-gamma activators. PMID: 19919817 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013348 Sun, 01 Nov 2009 00:00:00 +0100 3013348 http://www.medworm.com/index.php?rid=3013347&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919818%26dopt%3DAbstract Conclusions: Cholesteatomas possess the capacity for eroding bone and can have an insidious onset, but once established, grows relentlessly and destroys neighboring structures. Since a gradual intracranial involvement does not usually cause acute symptoms of increased intracranial pressure, the correct diagnosis may be difficult. Detailed clinical and radiographic studies in particular are diagnostically helpful. Because of the high incidence of delayed recurrence, life-long follow-up is required. The inconsistency in the histopathological classification of intracranial cholesteatomas should be clarified. PMID: 19919818 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013347 Sun, 01 Nov 2009 00:00:00 +0100 3013347 http://www.medworm.com/index.php?rid=3013346&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919819%26dopt%3DAbstract Conclusions: We confirmed the expression of 5-LO in various human brain tumors and demonstrated the partial suppression of tumor growth by inhibitors of the 5-LO-LTA4 hydrolase pathway in human glioma cell lines. The 5-LO-LTA4 pathway might play roles in the proliferation of human glioma cells. PMID: 19919819 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013346 Sun, 01 Nov 2009 00:00:00 +0100 3013346 http://www.medworm.com/index.php?rid=3013345&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919820%26dopt%3DAbstract Authors: Psaras T, Pantazis G, Steger V, Meyermann R, Honegger J, Beschorner R, Here we report the case of a 65-year-old female with a histologically benign parietal falcine meningioma who developed multiple lung metastases 15 years after tumor resection. The meningioma was initially incompletely resected due to invasion of the sagittal sinus. Since it was diagnosed as a benign meningothelial meningioma Grade I WHO, the residual tumor was followed with serial imaging without adjuvant treatment. The patient subsequently developed lung lesions later identified as metastases. The lung lesions were successfully removed surgically and histologically diagnosed as meningothelial meningioma Grade I WHO. A repeat brain MRI revealed the known residual meningioma with no signs of interval tumor ... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013345 Sun, 01 Nov 2009 00:00:00 +0100 3013345 http://www.medworm.com/index.php?rid=3013344&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19919821%26dopt%3DAbstract We describe a 58-year-old female with a supratentorial-intraaxial lesion that is consistent with a neurenteric cyst exhibiting malignant transformation into an invasive mucinous papillary cystadenocarcinoma. Areas of direct transition between typical benign neurenteric cyst epithelia and malignant epithelia (i.e., carcinoma in situ), highlighted by an abrupt change in the Ki-67 proliferative index, were identified, and supported the primary nature of this brain neoplasm. Metastatic workup at the time of presentation was unremarkable, and immediately up until being lost to follow-up 38 months after gross total resection, routine follow-up MR imaging had not detected a recurrence. To our knowledge, this would be the first reported case of malignant transformation within a supratentorial-intr... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=3013344 Sun, 01 Nov 2009 00:00:00 +0100 3013344 http://www.medworm.com/index.php?rid=2852577&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788047%26dopt%3DAbstract CONCLUSION: There was a good morphological and anatomical concordance between what was found with PET-blot and IHC in all patients. In some specific cases, the PET-blot was superior to IHC in sensitivity. To our knowledge, this is the first report where PET-blot analysis is applied to hereditary forms of human transmissible spongiform encephalopathies and compared with sporadic cases of Creutzfeldt-Jakob disease. PMID: 19788047 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852577 Mon, 31 Aug 2009 23:00:00 +0100 2852577 http://www.medworm.com/index.php?rid=2852576&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788048%26dopt%3DAbstract CONCLUSIONS: The nigral glial cells that expressed Herp at a high level resembled TUNEL-positive glia. While some of these cells likely undergo degeneration, the strong up-regulation of Herp in glia could help to explain the inflammation-like changes observed in PD ("neuroinflammation") as it has been shown that the unfolded protein response serves as an important regulator of inflammatory genes in other organs. PMID: 19788048 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852576 Mon, 31 Aug 2009 23:00:00 +0100 2852576 http://www.medworm.com/index.php?rid=2852575&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788049%26dopt%3DAbstract Authors: Seidel K, Brunt ER, de Vos RA, Dijk F, van der Want HJ, Rüb U, den Dunnen WF Neuronal protein aggregates are considered as pathological hallmarks of various human neurodegenerative diseases, including the so-called CAG-repeat disorders, such as spinocerebellar ataxia Type 6 (SCA6). Since the immunocytochemical findings of an initial post-mortem study using a specific antibody against the disease protein of SCA6 (i.e., pathologically altered alpha-1A subunit of the P/Q type voltage-dependent calcium channel, CACNA1A) have not been confirmed so far, the occurrence and central nervous system distribution of neuronal protein aggregates in SCA6 is still a matter of debate. Owing to the fact that the antibody against the pathologically altered CACNA1A is not commercially availa... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852575 Mon, 31 Aug 2009 23:00:00 +0100 2852575 http://www.medworm.com/index.php?rid=2852574&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788050%26dopt%3DAbstract CONCLUSION: Cortical pathology in PSP predominantly affects the lower laminae but may spread to affect the upper laminae in some cases. The NFT and GI may have different laminar distributions and gliosis occurs concurrently with neuronal enlargement. PMID: 19788050 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852574 Mon, 31 Aug 2009 23:00:00 +0100 2852574 http://www.medworm.com/index.php?rid=2852573&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788051%26dopt%3DAbstract CONCLUSIONS: We hypothesized that in the early stages of the disease neuronal involvement of apoptosis is limited to the cells of the brain stem, sparing the cortical area which is involved in neuronal apoptosis and cognitive decline later. PMID: 19788051 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852573 Mon, 31 Aug 2009 23:00:00 +0100 2852573 http://www.medworm.com/index.php?rid=2852572&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788052%26dopt%3DAbstract CONCLUSIONS: Our study shows that EGFR and p53 overexpression along with loss of PTEN expression are important adjuncts to clinical variables in prognosticating glioblastoma patients. PMID: 19788052 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852572 Mon, 31 Aug 2009 23:00:00 +0100 2852572 http://www.medworm.com/index.php?rid=2852571&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788053%26dopt%3DAbstract This study was undertaken to evaluate podoplanin as compared with EMA as a marker of ependymoma. A total of 16 ependymomas (WHO Grade (G) II, 9 cases; GIII, 4; myxopapillary, 2; GIII clear cell, (1) were immunohistochemically studied using antibodies against podoplanin (clones D2-40 and NZ-1) as well as an antibody against EMA (clone E29). In all cases, D2-40 and NZ-1 excellently labeled linear signals along the luminal surface of ependymal canals/rosettes, dot-like structures, and/or ringlike structures, as did E29. These structures were generally more abundant in GII ependymomas than in GIII ependymomas. A semiquantitative analysis between the immunopositive structures of D2-40 or NZ-1 and E29 was conducted with a focus on the dot-like structures and the ring-like structures in the cases... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852571 Mon, 31 Aug 2009 23:00:00 +0100 2852571 http://www.medworm.com/index.php?rid=2852570&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788054%26dopt%3DAbstract We report a case of an exclusively lateral ventricular tumor probably arising from the interventricular septum and blocking the CSF pathway. To the best of our knowledge, this is the first reported case of an exclusively intraventricular gliosarcoma. PMID: 19788054 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852570 Mon, 31 Aug 2009 23:00:00 +0100 2852570 http://www.medworm.com/index.php?rid=2852569&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788055%26dopt%3DAbstract Authors: Treacy A, Redmond M, Lynch B, Ryan S, Farrell M, Devaney D A 7-year-old boy with a history of VACTERL syndrome was found collapsed in bed. MRI had shown basilar invagination of the skull base and narrowing of the foramen magnum. Angulation, swelling and abnormal high signal at the cervicomedullary junction were felt to be secondary to compression of the medulla. Neuropathologic examination showed bilateral replacement of the medullary tegmentum by an irregularly circumscribed cellular lesion which was composed of elongated GFAP/S 100-positive cells with spindled nuclei and minimal atypia. The pathologic findings were interpreted as intramedullary schwannosis with mass effect. Schwannosis, is observed in traumatized spinal cords where its presence may represent attempted, albei... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852569 Mon, 31 Aug 2009 23:00:00 +0100 2852569 http://www.medworm.com/index.php?rid=2852568&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788056%26dopt%3DAbstract CONCLUSION: A diagnosis of pineal melanoma should be considered in the presence of a pineal mass that appears hyperintense on T1-weighted images and hypo- to isointense on T2-weighted images. The diagnosis is provided by pathological examination of tumor specimens obtained at surgical resection or at leptomeningeal biopsy. However, immunochemistry using anti-Melan-A, -S100 protein and/or -HMB45 antibodies on cerebrospinal fluid and leptomeningeal samples may be helpful in diagnosing such a disease. The prognosis of primary pineal melanoma is variable but meningeal spreading carries a dismal prognosis. The best therapeutic management is yet to be defined. PMID: 19788056 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852568 Mon, 31 Aug 2009 23:00:00 +0100 2852568 http://www.medworm.com/index.php?rid=2852567&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19788057%26dopt%3DAbstract Authors: Mesfin FB, Drazin D, Berry S, Homan S, Nazeer T, German JW A 72-year-old right-handed woman presented with a 6-month history of right thoracic wall discomfort. An MRI of the thoracic spine showed a small dumbbell-shaped mass centered within the right T7-8 foramen. The patient was asked to return to clinic for reevaluation to include a new MRI of the thoracic spine in 6 months. She did not comply with this recommendation and 1 year later, she presented with increasing difficulty ambulating and spastic paraparesis. A follow-up MRI of the thoracic spine now demonstrated significant interval growth of the mass with an extra-foraminal component extending into the thoracic cavity. She was taken to the operating room for resection of the epidural tumor. The pathology was consistent w... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2852567 Mon, 31 Aug 2009 23:00:00 +0100 2852567 http://www.medworm.com/index.php?rid=2662334&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642504%26dopt%3DAbstract Authors: Sinis N, Kraus A, Papagiannoulis N, Werdin F, Schittenhelm J, Meyermann R, Haerle M, Geuna S, Schaller HE Nerve injuries may result in sensory and motor deficits when not treated appropriately. Especially the surgical management of nerve defects still represents a challenge for the surgeon. In these cases the grafting of autologous nerves represents the only reasonable approach. Due to the side effects associated with this method (sacrifice of donor nerves, neuroma formation in the harvesting area, limited availability of donor nerves, etc.), numerous alternatives were proposed in order to avoid the transplantation of autologous tissue. This review provides a general view on the state of the art of how to supply gaping injuries in the peripheral nerve. Furthermore new approach... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662334 Tue, 30 Jun 2009 23:00:00 +0100 2662334 http://www.medworm.com/index.php?rid=2662333&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642505%26dopt%3DAbstract CONCLUSION: Despite the fact that a definite diagnosis of NPD Type A depends on enzymatic assays and/or molecular analysis, morphological investigation remains an important diagnostic procedure. Well-defined and complete neuropathological information about the ASMKO mouse model, inclusive of PNS examination, may be crucial in the pre-clinical evaluation of new therapies. PMID: 19642505 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662333 Tue, 30 Jun 2009 23:00:00 +0100 2662333 http://www.medworm.com/index.php?rid=2662332&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642506%26dopt%3DAbstract CONCLUSIONS: Our neuropathologic data confirmed the notion that dementia in retired boxers could be due to several factors such as DP, multiple cerebral infarcts and Wernicke-Korsakoff syndrome. Our findings illustrate the need to comprehensively examine former boxers with dementia as well as carefully evaluate the neuropathologic changes that may cause or contribute to the patient's cognitive and behavioral symptoms. Such an approach is crucial in order to provide prompt and more definitive therapies. PMID: 19642506 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662332 Tue, 30 Jun 2009 23:00:00 +0100 2662332 http://www.medworm.com/index.php?rid=2662331&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642507%26dopt%3DAbstract We describe here a case of a meningioma in a 9-year-old girl unusual in two aspects. Firstly, it arose from the cavernous sinus what is exceptional in children. Secondly, despite the big tumor mass the child was almost asymptomatic. The only symptoms at presentation were a slight facial asymmetry and minimal laterodeviation of her mandible. Those symptoms had not been noticed by her parents and were detected during careful routine dental examination. The clinical course was quite aggressive and several neurosurgical interventions were necessary. This case underlines the importance of careful medical and dental examination during routine checkup consultations and undertaking necessary diagnostic procedures aimed at elucidating of all detected, even minimal abnormalities. PMID: 19642507 ... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662331 Tue, 30 Jun 2009 23:00:00 +0100 2662331 http://www.medworm.com/index.php?rid=2662329&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642508%26dopt%3DAbstract CONCLUSIONS: Although histopathology is usually characteristic, imaging features may also be important in the presurgical evaluation of PGNTs. Gross total resections are usually possible and seem to govern prognosis. However, longer follow-up data are required. PMID: 19642508 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662329 Tue, 30 Jun 2009 23:00:00 +0100 2662329 http://www.medworm.com/index.php?rid=2662328&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642509%26dopt%3DAbstract CONCLUSION: PTPR is a distinct entity and needs to be differentiated from other tumors of the pineal region as the biological behavior of this tumor is not fully understood. Radiologically this tumor can sometimes be misdiagnosed as tectal glioma. PMID: 19642509 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662328 Tue, 30 Jun 2009 23:00:00 +0100 2662328 http://www.medworm.com/index.php?rid=2662327&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642510%26dopt%3DAbstract We report a rapidly recurring folliculostellate cell tumor of the adenohypophysis in a 63-year-old woman. Morphologically the tumor had the typical appearance of a spindle cell oncocytoma of the adenohypophysis. It recurred within 5 months of selective transsphenoidal resection, requiring a second transsphenoidal operation followed by radiation therapy. The spindle cell oncocytoma (SCO) of the adenohypophysis is a relatively recently described entity and a new addition to the fourth edition of the WHO Classification of Tumors of the Central Nervous System. In our case, the ultrastructural features were significantly different from those so far described in SCO, in that tumor cells formed a network of structures indistinguishable from pituitary follicles. In addition, a minority of tumor ce... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662327 Tue, 30 Jun 2009 23:00:00 +0100 2662327 http://www.medworm.com/index.php?rid=2662326&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19642511%26dopt%3DAbstract Authors: Weiss S, Siebzehnrübl FA, Kreutzer J, Blümcke I, Buslei R The ability to isolate and propagate adult stem/progenitor cells from the human brain opens novel avenues for cell replacement therapy. This will also apply to the pituitary gland, i.e., following tumor induced endocrine deficiency. Herein, we examine autopsy derived pituitaries to unravel a putative stem/progenitor cell population in humans. In tissue sections of the anterior lobe nestin immunoreactive cells co-expressing smooth muscle actin (SMA) were identified in the perivascular space, indicating a pericytic differentiation. Under clonal conditions, this particular cell population generated primary and secondary cell aggregates (spheres). Pituitary cell cultures maintained a stable cell cycle length with ... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2662326 Tue, 30 Jun 2009 23:00:00 +0100 2662326 http://www.medworm.com/index.php?rid=2537404&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19537130%26dopt%3DAbstract The objective of this study was to investigate the therapeutic effects of doxorubicin bound to polysorbate-coated nanoparticles that had previously been shown to significantly enhance survival in the orthotopic rat 101/8 glioblastoma model. Tumor-bearing animals were subjected to chemotherapy using doxorubicin in solution (Dox-sol) or doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles (Dox-np) injected intravenously on Days 2, 5 and 8 post tumor implantation. The antitumor effect was assessed on Days 10, 14 and 18 post tumor implantation. Tumors showed signs of malignancy including invasion of brain tissue, brisk mitotic activity, microvascular proliferation, necrosis and increased proliferation resembling human glioblastoma. Dox-np produced a considerably m... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2537404 Thu, 30 Apr 2009 23:00:00 +0100 2537404 http://www.medworm.com/index.php?rid=2537403&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19537131%26dopt%3DAbstract We present a unique case of a brain tumor patient with atypical location and progression. He was initially presented with mood and anxiety type symptoms together with aphasia and left-sided paraesthesias. Magnetic resonance imaging and CSF were negative and the patient was diagnosed with PTSD as he recently experienced a small motor vehicle accident. Two months after the first presentation, MRI revealed multifocal juxtacortical, leptomeningeal hyperdensities in the bilateral frontal lobes. MRI-guided frameless stereotactic biopsy defined a diagnosis of GBM 1 week prior to death which occurred within 4 months. Postmortally, formalin-fixed brain demonstrated that the main tumor mass was located in the fornix, infiltrating the ventricular system and disseminating over the cortex, cerebellum a... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2537403 Thu, 30 Apr 2009 23:00:00 +0100 2537403 http://www.medworm.com/index.php?rid=2537402&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19537132%26dopt%3DAbstract We report a very rare case of GBM with abundant RFs. CASE REPORT: A 60-year-old woman presented with a 6-month history of difficulty coordinating her right hand, occasional intermittent diplopia, and occasional dizzy spells. An MRI showed a heterogeneously enhancing, infiltrating mass lesion with a cystic component involving the left midbrain, thalamus, and posterior basal ganglia. Biopsy was performed. Cytologic touch imprints revealed fibrillary astrocytic cells possessing oval nuclei and long delicate processes with abundant RFs. Histologic sections showed diffusely infiltrating astrocytoma with prominent RFs diffusely distributed throughout the tumor, brisk mitotic activity, vascular proliferation, and small areas of necrosis, as seen in a GBM. The Ki-67 (MIB-1) labeling index was 7.1%... Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2537402 Thu, 30 Apr 2009 23:00:00 +0100 2537402 http://www.medworm.com/index.php?rid=2537401&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19537133%26dopt%3DAbstract We report a patient who had pilocytic astrocytoma in the cerebellum and ependymoma in the cauda equina region, occurring simultaneously. The suggested mechanism of this association is that primitive multipotent cells might have been displaced in the different CNS areas and developed in different tumor cells. Multiplicity of primary CNS tumors should be considered in certain occasions, when clinical symptoms and signs are pointing in that direction. PMID: 19537133 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2537401 Thu, 30 Apr 2009 23:00:00 +0100 2537401 http://www.medworm.com/index.php?rid=2537400&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19537134%26dopt%3DAbstract CONCLUSIONS: Our case of adamantinomatous CP that developed long after removal of the RCC, diagnosed by beta-catenin staining, supports the hypothesis that CPs may develop from RCCs directly due to beta-catenin mutations. However, it still does not prove that a histogenetic connection can be shown between the two lesions which are clonally unrelated. Our case is reported as two consecutive lesions; this in itself is a rare situation. PMID: 19537134 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2537400 Thu, 30 Apr 2009 23:00:00 +0100 2537400 http://www.medworm.com/index.php?rid=2537399&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19537135%26dopt%3DAbstract CONCLUSION: The cytogenesis of plurihormonal pituitary adenomas is not fully understood. Further investigations are required to clarify the basis for their plurihormonality despite an ultrastructural gonadotroph phenotype. PMID: 19537135 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2537399 Thu, 30 Apr 2009 23:00:00 +0100 2537399 http://www.medworm.com/index.php?rid=2537398&cid=s_38105_32_f&fid=38105&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19537136%26dopt%3DAbstract CONCLUSIONS: Our experience with this unique case illustrates the challenges of diagnosing a primary leptomeningeal neoplasm. This case also underscores the importance of maintaining a high degree of suspicion for leptomeningeal neoplasms in patients who present with imaging studies suspicious for Chiari I malformation. PMID: 19537136 [PubMed - in process] (Source: Clinical Neuropathology) Clinical Neuropathology journals http://www.medworm.com/rss/comments.php?id=2537398 Thu, 30 Apr 2009 23:00:00 +0100 2537398