Clinical Physiology and Functional Imaging via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical Physiology and Functional Imaging' source. Mon, 15 Mar 2010 15:38:19 +0100 Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance http://www.medworm.com/index.php?rid=3320560&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00910.x Glomerular filtration rate (GFR) measurement by 51Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from 99mTc-diethylene triamine pentaacetic acid (DTPA) renography and compared with 51Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4·7 years). The correlation between 99mTc-DTPA renography and 51Cr-EDTA plasma clearance was for all children R = 0·96 (n = 29, P (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3320560 Tue, 02 Mar 2010 00:00:00 +0100 3320560 Computational and physiological background of the baroreflex sensitivity http://www.medworm.com/index.php?rid=3300502&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2010.00928.x All the commonly used definitions of baroreflex sensitivity (BRS) are based on a slope of linear relationship between systolic blood pressure and pulse interval (R[ndash]R interval). However, heart rate (HR) and R[ndash]R interval bear an inverse non-linear relationship, which distorts determination of BRS when different HR levels are present. We analysed data of 117 healthy, normal-weight, non-smoking men and women aged 23[ndash]77 to show how BRS depends on the initial HR. In this data, 43% of variation in BRS is solely explained by HR. Comparisons of BRS between patients with different HR and even within the same patient with changing HR (e.g. tilt-table test and nocturnal changes in HR) should be questioned. Consideration of the baseline HR is even more crucial, if the patients are sub... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3300502 Wed, 24 Feb 2010 00:00:00 +0100 3300502 Validity of Oxycon Mobile in measuring inspiratory capacity in healthy subjects http://www.medworm.com/index.php?rid=3300504&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2010.00924.x Discussion: The limits of agreement of the IC measured by OM and OP were ±10%, which is recommended for interdevice reproducibility. We conclude that OM and OP can be used interchangeably for measuring IC at rest and during steady-state exercise. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3300504 Tue, 23 Feb 2010 00:00:00 +0100 3300504 Variation and reliability of ultrasonographic quantification of the architecture of the medial gastrocnemius muscle in young children http://www.medworm.com/index.php?rid=3300503&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2010.00925.x The aim of this study was to evaluate the suitability of ultrasonography for the quantification of gastrocnemius muscle architecture in healthy young children. The variation and reliability of measurement of muscle thickness, pennation angle and fibre length of the medial gastrocnemius were determined, using stationary and portable ultrasound machines, in 13 boys and eight girls aged 4[ndash]10. Ultrasound images were obtained from each leg, in duplicate, with the ankle at 90°, then at maximal plantar flexion, with the two machines within the same session. The same set of 16 scans was repeated in four children 4[ndash]6 weeks later. The mean muscle thickness, pennation angle and fibre length differed between ankle positions and between legs. Measurements obtained using the two machines es... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3300503 Tue, 23 Feb 2010 00:00:00 +0100 3300503 Effects of low-intensity resistance exercise with blood flow restriction on coagulation system in healthy subjects http://www.medworm.com/index.php?rid=3281964&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2010.00927.x Recent studies have demonstrated that even a low-intensity resistance exercise can effectively induce muscle hypertrophy and strength increase when combined with moderate blood flow restriction (BFR) into the exercising muscle. Although serious side effects of low-intensity resistance exercise with BFR have not been reported, a concern of thrombosis has been suggested, because this type of exercise is performed with restricted venous blood flow and pooling of blood in extremities. Thus, the purpose of this study was to investigate the effects of low-intensity resistance exercise with BFR on coagulation system in healthy subjects. Ten healthy men (25·1 ± 2·8 year) performed four sets of leg press exercises with and without BFR (150[ndash]160 mmHg) at an intensity of 30% of one-repetition... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3281964 Thu, 18 Feb 2010 00:00:00 +0100 3281964 Pulmonary oedema in healthy SCUBA divers: new physiopathological pathways http://www.medworm.com/index.php?rid=3242113&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2010.00922.x Conclusion: Immersion, body cooling, hyperoxia, increased hydrostatic pressure and strenuous exercise likely combine to induce pulmonary oedema in patients without cardiac disease. This study underlines new physiopathological tracks related to the frequent occurrence of symptoms noticed in the last part of the ascent and a higher incidence in women. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3242113 Fri, 05 Feb 2010 00:00:00 +0100 3242113 The effect of peripheral vascular disease on structure and function of resistance arteries isolated from human skeletal muscle http://www.medworm.com/index.php?rid=3218903&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00923.x Peripheral vascular disease (PVD) is associated with numerous pathophysiological adaptations of the microvasculature. Considering this, active and passive pressure-dependent and pressure-independent mechanisms of vascular control were studied in small resistance arteries isolated from patients with PVD. Using pressure myography and confocal microscopy, human skeletal muscle arteriolar structure and function were compared between paired arteries; one isolated from the healthy non-diseased proximal skeletal muscle vascular bed (PSM, internal control) and the other from the diseased ischaemic part of the leg [distal skeletal muscle (DSM)]. Structurally, arteries isolated from the diseased part of the leg displayed significant atrophy compared with the non-diseased arteries. Functionally, no d... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3218903 Fri, 29 Jan 2010 00:00:00 +0100 3218903 Decreased leg glucose uptake during exercise contributes to the hyperglycaemic effect of octreotide http://www.medworm.com/index.php?rid=3218905&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00917.x Aim: During prolonged infusion of somatostatin, there is an increase in arterial glucose concentration, and this increase persists even during prolonged exercise. The aim of the study was to measure glucose uptake in the leg muscles during infusion of the somatostatin analogue octreotide before and during leg exercise.Material and methods: Eight healthy male subjects were investigated twice in the fasting state: during 3 h infusion of octreotide [30 ng (kg min)[minus]1] or sodium chloride with exercise at 50% of maximal VO2 in the last hour. Glucose uptake and oxygen uptake in the leg were measured using Fick's principle by blood sampling from an artery and a femoral vein. Blood flow in the leg was measured using the indicator (indocyanine green) dilution technique.Results: After an initia... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3218905 Thu, 28 Jan 2010 00:00:00 +0100 3218905 Late potentials and QT dispersion after high-dose chemotherapy in patients with non-Hodgkin lymphoma http://www.medworm.com/index.php?rid=3218904&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00920.x The most common cardiotoxic effects of high-dose cyclophosphamide (CY) are electrocardiographic changes and transient arrhythmias. Therefore, we prospectively assessed serial electrocardiogram (ECG) and signal-averaged electrocardiogram (SAECG) recordings in 30 adult patients with non-Hodgkin lymphoma (NHL) receiving high-dose CY as part of high-dose chemotherapy (HDT) regimen. All patients were treated with anthracyclines earlier. Heart-rate-corrected QT interval and QT dispersion (QTc and QTc dispersion) were measured from ECG. QRS duration and late potentials (LPs) were analysed from SAECG. Both ECG and SAECG were recorded 1 day (d) prior to HDT (d[minus]7) at baseline, and 1 day (d[minus]2), 7 days (d+7), 12 days (+12) and 3 months (m+3) after HDT. Stem cells were infused on day 0 (d0)... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3218904 Thu, 28 Jan 2010 00:00:00 +0100 3218904 Human in vivo study of the renin–angiotensin–aldosterone system and the sympathetic activity after 8 weeks daily intake of fermented milk http://www.medworm.com/index.php?rid=3210636&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00921.x Conclusions: Despite a known ACE inhibitory effect in vitro and in animals, milk fermented with Lb. helveticus did not inhibit ACE in humans. Our results suggest that the intake of fermented milk decreases sympathetic activity, although not to an extent mediating reductions of blood pressure and heart rate in borderline-hypertensive subjects. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3210636 Wed, 27 Jan 2010 00:00:00 +0100 3210636 Muscle blood flow response to mental stress and adrenaline infusion in man: microdialysis ethanol technique compared to 133Xe clearance and venous occlusion plethysmography* http://www.medworm.com/index.php?rid=3210637&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00919.x Background and aim: Adrenaline, administered locally by microdialysis in skeletal muscle, causes vasoconstriction around the microdialysis catheter. This is contrary to the vasodilation that normally occurs when adrenaline is infused intravenously or intra-arterially. The hypothesis was tested that vasoconstriction, measured by microdialysis, would not occur with two interventions causing increased plasma levels of adrenaline, mental stress and intravenous adrenaline infusion (0·1 nmol kg[minus]1 min[minus]1).Methods: Twenty-four men (27 ± 1·6 years) underwent these interventions. Blood flow was determined by the microdialysis ethanol technique and 133Xe clearance (gastrocnemius muscle, medial head) and by venous occlusion plethysmography (calf).Results: The ethanol outflow/inflow ratio... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3210637 Tue, 26 Jan 2010 00:00:00 +0100 3210637 Brain electrical activity during food presentation in obese binge-eating women http://www.medworm.com/index.php?rid=3187705&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00916.x Binge-eating (BE) subjects have shown altered brain activity at frontal regions during food presentation. The aim of this study was to examine the frontal brain electrical activity in obese BE women (n = 12) and in obese women without BE (non-BE, n = 13). Brain electrical activity was measured using a quantitative electroencephalography during a resting state (eyes-closed) and when the subjects focused (eyes-open) their attention on a picture of a landscape (control experiment) or on a meal (food experiment). The BE showed greater frontal beta activity (14[ndash]20 Hz) than the non-BE in both the eyes-closed (on average 52%) and the eyes-open situations and independently of the stimulus (control experiment: 57% and food experiment: 71%). No significant differences between the groups were f... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3187705 Wed, 20 Jan 2010 00:00:00 +0100 3187705 Respiratory indices by gas analysis and fat metabolism by indirect calorimetry in normal subjects and triathletes http://www.medworm.com/index.php?rid=3187704&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00918.x Background: The effects of exercise on different indices reflecting the metabolism have been of interest for a long time, and a relationship between anaerobic indices and maximal oxygen uptake has been established. The inter-relationship between different respiratory indices during an exercise test remains to be studied in order to understand differences between individuals. Therefore, the aim of this study was to determine three respiratory indices and investigate their inter-relationship in individuals with highly variable working capacity. A second aim was to investigate the fat metabolism at the VO2 corresponding to the respiratory compensation point (Pq) in the different subjects using indirect calorimetry.Methods: Sixty control subjects (20 female) and 18 triathletes (six female) per... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3187704 Wed, 20 Jan 2010 00:00:00 +0100 3187704 Bone mineral density in diabetes mellitus patients with and without a Charcot foot http://www.medworm.com/index.php?rid=3181218&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00915.x Conclusions: From this study, we can conclude that there were no differences in BMD values in the spine and hip between groups. There were no differences between BMD of the calcaneus between groups, except that patients with chronic Charcot had a significantly lower calcaneal BMD in the affected foot than in the healthy foot. Furthermore, there was an increased bone turnover in the group with acute CA, which was not found in the other patients groups. This suggests that the Charcot foot is a rather local phenomenon, with little effect on the skeleton in general. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3181218 Mon, 18 Jan 2010 00:00:00 +0100 3181218 Image quality and myocardial scar size determined with magnetic resonance imaging in patients with permanent atrial fibrillation: a comparison of two imaging protocols http://www.medworm.com/index.php?rid=3117440&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00914.x Background: Magnetic resonance imaging (MRI) of the heart generally requires breath holding and a regular rhythm. Single shot 2D steady-state free precession (SS_SSFP) is a fast sequence insensitive to arrhythmia as well as breath holding. Our purpose was to determine image quality, signal-to-noise (SNR) and contrast-to-noise (CNR) ratios and infarct size with a fast single shot and a standard segmented MRI sequence in patients with permanent atrial fibrillation and chronic myocardial infarction.Methods: Twenty patients with chronic myocardial infarction and ongoing atrial fibrillation were examined with inversion recovery SS_SSFP and segmented inversion recovery 2D fast gradient echo (IR_FGRE). Image quality was assessed in four categories: delineation of infarcted and non-infarcted myoca... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3117440 Thu, 24 Dec 2009 00:00:00 +0100 3117440 Human microvascular imaging: a review of skin and tongue videomicroscopy techniques and analysing variables http://www.medworm.com/index.php?rid=3117442&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00913.x Imaging techniques are increasingly important in clinical diagnostic work. Microcirculation is essential for function and survival of all tissues, but imaging techniques for microvascular monitoring of patients have only been used to a limited extent in clinical practice. The microcirculation is complex with its static and dynamic feature, and only skin and oral mucosa are readily accessible for microscopic examination. In addition, there is a no general agreement on which microvascular parameters and analysing techniques that could be useful. The aim of this article is to give an overview of techniques for human intra-vital microscopy and to describe software and variables used to analyse pictures and film sequences of human microcirculation. We also present clinical examples where microv... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3117442 Wed, 23 Dec 2009 00:00:00 +0100 3117442 Electromyographic tools to assess hemidiaphragm paralysis http://www.medworm.com/index.php?rid=3117441&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00911.x Non-invasive measurements of the phrenic nerve conduction time (CT) and diaphragmatic electromyographic response to voluntary inspiratory efforts may help to document an abnormal diaphragmatic function in the presence of hemidiaphragm elevation on chest radiographs. Twenty-one patients were addressed for the diagnosis of abnormal placement and motion of the right (13) or left (8) cupola on chest radiographs. CT was measured by recording the diaphragmatic M-wave evoked by electrical transcutaneous phrenic nerve stimulation. The integrated diaphragmatic surface electromyogram (Edi) was recorded during sniff and Müller manoeuvres. Four patients were followed up during the next 8[ndash]16 months. Among the twenty-one patients, five (24%) had a lengthened or absent CT. A right-to-left peak Edi... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3117441 Wed, 23 Dec 2009 00:00:00 +0100 3117441 Functional versus radiological assessment of chronic intestinal ischaemia http://www.medworm.com/index.php?rid=3021482&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00912.x Discussion: In this cohort, SBF detects CII with sensitivity of 1·0, and specificity of 0·95. SBF supplies additional information in patients with convincing symptoms and normal angiography. In these patients, the affection of the intestinal arteries may be too distant or too subtle to be visualized on angiography. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=3021482 Tue, 24 Nov 2009 00:00:00 +0100 3021482 Diagnostic performance and partition values of exercise electrocardiographic variables in the detection of coronary artery disease – improved accuracy by using ST/HR hysteresis http://www.medworm.com/index.php?rid=2998157&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00909.x This study compares the measurements of ST-segment changes during exercise and during early postexercise recovery in terms of diagnostic discrimination capacity and optimal partition values. Data from 1876 patients undergoing a routine bicycle exercise test were analysed. CAD was angiographically verified in 668 patients, and excluded by angiography (n = 119), myocardial scintigraphy (n = 250), and on clinical grounds (n = 839) in 1208 patients. Postexercise ST/HR hysteresis was calculated as normalized for heart rate (HR) ST/HR loop area during the first 3 min of recovery. ST/HR index was obtained by dividing the overall ST amplitude change during exercise by exercise-induced HR change, and ST/HR slope was calculated using linear regression analysis of ST/HR data pairs during exercise. ST... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2998157 Tue, 17 Nov 2009 00:00:00 +0100 2998157 Diagnostic performance of cardiac magnetic resonance imaging in coronary artery disease http://www.medworm.com/index.php?rid=2976105&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00908.x Conclusions: We conclude that evaluation of CAD is feasible in patients with different severity of CAD using visually analysed CMR, especially when available CMR methodologies are combined together. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2976105 Tue, 10 Nov 2009 00:00:00 +0100 2976105 Assessment of left ventricular systolic function using tissue Doppler imaging in children after successful repair of aortic coarctation http://www.medworm.com/index.php?rid=2953263&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00894.x Conclusions: Left ventricular systolic performance in children after the surgical repair of aortic coarctation reveals tendency to rise in late follow-up despite a satisfactory result after surgery. Higher systolic strain and SR in children treated due to coarctation of the aorta may suggest the increased preserved left ventricular performance despite normalization of afterload. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2953263 Tue, 03 Nov 2009 00:00:00 +0100 2953263 Relationship between arterial baroreflex sensitivity and exercise capacity in patients with acute myocardial infarction http://www.medworm.com/index.php?rid=2929644&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00906.x To investigate the relationship between arterial baroreflex sensitivity (BRS) and exercise capacity, we examined arterial BRS and its relation to exercise capacity during upright bicycle exercise in 40 uncomplicated patients with acute myocardial infarction. Arterial BRS was measured 3 weeks (20 ± 5 days) after acute myocardial infarction and assessed by calculating the regression line relating phenylephrine-induced increases in systolic blood pressure to the attendant changes in the R[ndash]R interval. All patients underwent graded symptom-limited bicycle exercise with direct measurements of hemodynamic and metabolic measurements. In all patients, the average arterial BRS was 5·6 ± 2·6 ms mmHg[minus]1. There were no significant correlations between arterial BRS and hemodynamic measure... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2929644 Tue, 27 Oct 2009 00:00:00 +0100 2929644 Preliminary evaluation of novel 68Ga-DOTAVAP-PEG-P2 peptide targeting vascular adhesion protein-1 http://www.medworm.com/index.php?rid=2889029&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00907.x Conclusions: These basic and essential in vitro and in vivo studies of the new VAP-1 targeting peptide revealed promising properties for an imaging agent. Further investigations to clarify in vivo VAP-1 targeting are warranted. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2889029 Tue, 13 Oct 2009 23:00:00 +0100 2889029 Urea clearance: a new method to register local changes in blood flow in rat skeletal muscle based on microdialysis http://www.medworm.com/index.php?rid=2874431&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00904.x Increasing evidence suggests that local blood flow should be monitored during microdialysis (MD) as the recovery of analytes is affected by local blood flow. At present ethanol clearance is the standard technique for this purpose, but it is not functional at very low perfusion velocities. Here, we introduce a technique for MD whereby local tissue blood flow is recorded by the use of urea clearance (changes inflow/outflow concentration), in conjunction with measurements of tissue metabolism (glucose, lactate and puruvate). MD probes were inserted into the gracilis muscle of 15 rats and perfused with a medium containing urea (20 mmol l[minus]1). Changes in muscle blood flow were made by addition of noradrenaline (5 [mu]g ml[minus]1) to the perfusion medium at two perfusion velocities (0·6 a... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2874431 Thu, 08 Oct 2009 23:00:00 +0100 2874431 Haemodynamic effects of patent foramen ovale and atrial septal defect closure: a comparison during percutaneous shunt closure http://www.medworm.com/index.php?rid=2860890&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00905.x Conclusions: Using non-invasive finger pressure measurements, we found that SV, mean and systolic blood pressure increased immediately after percutaneous closure of an ASD in adults, whereas the percutaneous PFO closure had no effect on haemodynamic characteristics. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2860890 Sun, 04 Oct 2009 23:00:00 +0100 2860890 Influence of smoking abstinence and nicotine replacement therapy on heart rate and QT time-series http://www.medworm.com/index.php?rid=2854112&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00902.x We examined the influence of smoking cessation, during cold-turkey and subsequent NRT, on HR and QT time-series during 30 days of smoking abstinence. Seven smokers and sixteen healthy non-smokers received ECG monitoring at baseline (Day 0). Smokers subsequently refrained from smoking without using NRT for 24 h, and then received NRT for 29 days. ECG monitoring was repeated at Days 1, 7, 30. Following smoking cessation we observed that: HR and rate-corrected QT were both reduced, heart rate variability (HRV) increased (improved), and QT variability index (QTVI) showed signs of improvement (trend only). Improvements in HR and QT were maintained throughout NRT use, whilst improvements in HRV and QTVI were sustained for at least the early stages of NRT. The dynamic (multifractal) properties of... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2854112 Thu, 01 Oct 2009 23:00:00 +0100 2854112 Gait analysis in elderly adult patients with mild cognitive impairment and patients with mild Alzheimer's disease: simple versus dual task: a preliminary report http://www.medworm.com/index.php?rid=2854111&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00903.x Conclusion: At the end of this preliminary study, we defined a specific gait pattern for each cognitive profile. Further researches appear necessary to enlarge the study cohort. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2854111 Thu, 01 Oct 2009 23:00:00 +0100 2854111 Parametric quantification of myocardial ischaemia using real-time perfusion adenosine stress echocardiography images, with SPECT as reference method http://www.medworm.com/index.php?rid=2837836&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-0961.2009.00901.x Background: Real-time perfusion (RTP) adenosine stress echocardiography (ASE) can be used to visually evaluate myocardial ischaemia. The RTP power modulation technique, provides images for off-line parametric perfusion quantification using Qontrast® software. From replenishment curves, this generates parametric images of peak signal intensity (A), myocardial blood flow velocity ([beta]) and myocardial blood flow (Ax[beta]) at rest and stress. This may be a tool for objective myocardial ischaemia evaluation. We assessed myocardial ischaemia by RTP-ASE Qontrast®-generated images, using 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) as reference.Methods: Sixty-seven patients admitted to SPECT underwent RTP-ASE (SONOS 5500) during Sonovue® infusion, before and througho... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2837836 Sun, 27 Sep 2009 23:00:00 +0100 2837836 Analysis of human myocardial dynamics using virtual markers based on magnetic resonance imaging http://www.medworm.com/index.php?rid=2822700&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00900.x Background: Myocardial dynamics are three-dimensional (3D) and time-varying. Cineradiography of surgically implanted makers in animals or patients is accurate for assessing these events, but this invasive method potentially alters myocardial motion. The aim of the study was to quantify myocardial motion using magnetic resonance imaging (MRI) and hence to provide a non-invasive approach to characterize 3D myocardial dynamics.Methods: Myocardial motion was quantified in ten normal volunteers by tracking the Lagrangian motion of individual points (i.e. virtual markers), based on time-resolved 3D phase-contrast MRI data and Fourier tracking. Nine points in the myocardium were tracked over the entire cardiac cycle, allowing a wire frame model to be generated and systolic and diastolic events id... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2822700 Tue, 22 Sep 2009 23:00:00 +0100 2822700 Ultrasound measures of muscle thickness: intra-examiner reliability and influence of body position http://www.medworm.com/index.php?rid=2787758&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00897.x Ultrasound is an inexpensive and practical alternative to gold standard measures of muscle mass. Changes in body position may lead to intra-muscular fluid shifts that may affect the reliability of ultrasound measures. We assessed test[ndash]retest reliability of ultrasound measures of muscle thickness and the effect of position on these measures. Measures of muscle thickness were made from B-mode ultrasound images in 18 healthy participants. Repeated measurements were made by one examiner from two participant positions; standing and recumbent, from 18 anatomical sites. Results demonstrated high test[ndash]retest reliability for measures taken in both participant positions [intra-class coefficient (ICC) scores 0·65 to 0·94], except for the recumbent posterior lower leg measures (ICC 0·34... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2787758 Fri, 11 Sep 2009 23:00:00 +0100 2787758 Cardiac vagal activity following three intensities of exercise in humans http://www.medworm.com/index.php?rid=2784680&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00899.x In this study, the recovery of the ANS, in particular indices of vagal activity were measured postexercise, at three intensities similar to current international recommendations for health. Thirteen individuals (six females, 22·2 ± 3·1 years) performed three 20-min constant load tests lying supine on a modified bicycle ergometer at the following intensities: moderate (2 mmol l[minus]1 blood lactate concentration, BLC); hard (3 mmol l[minus]1BLC); and vigorous (4 mmol l[minus]1BLC) as derived from a maximal test. ECG data were collected during 5-min epochs at baseline then at: 5, 15, 30, 45 and 65-min postexercise. Heart rate variability (HRV) analysis was performed to obtain R[ndash]R interval, standard time [root mean square of successive differences (RMSSD)] and frequency measures [na... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2784680 Thu, 10 Sep 2009 23:00:00 +0100 2784680 Adaptative or maladaptative hypertrophy, different spatial distribution of myocardial contraction http://www.medworm.com/index.php?rid=2784682&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00896.x Conclusion: In patients with pathological LVH, LV longitudinal strain was reduced, while circumferential deformation and torsion were increased. No differences were observed in LV contractile function between subjects with adaptative LVH and controls. In pathological LVH, increasing torsion could be considered a compensatory mechanism to counterbalance contraction and relaxation abnormalities to maintain a normal LV output. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2784682 Wed, 09 Sep 2009 23:00:00 +0100 2784682 Measurement of physical work capacity in patients with chronic aortic regurgitation: a potential improvement in patient management http://www.medworm.com/index.php?rid=2784681&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00895.x Conclusion: LVEF, diameters and volumes at rest did not fulfil the criteria for surgery in most of our AR patients, of whom 46% were asymptomatic. However, many had a remarkably low work capacity, which was neither improved 6 months postoperatively nor correlated to echocardiographic LV dimensions. CPET predicted the postoperative work capacity and may, therefore, be a useful complement for timing of surgery in patients with chronic AR. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2784681 Wed, 09 Sep 2009 23:00:00 +0100 2784681 The effect of spironolactone on sweat and urinary sodium excretion during exercise in humans http://www.medworm.com/index.php?rid=2760602&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00898.x This study examined the effect of spironolactone on urinary ([Na+]urine) and sweat sodium concentration ([Na+]sweat) when controlling for sweat rate. Fifteen healthy subjects were required to complete two 90-min exercise bouts (three 30-min ordered exercise bouts at 60%, 70%, and 80% of the subjects' age-predicted maximum heart rate) in a 35°C and 40% relative humidity environmental chamber, once after administration of 300 mg spironolactone, and once after administration of 300 mg placebo. Both the drug and placebo were taken over an 18 h period, with the second 100 mg dose taken 6 h prior to exercise, and the first 200 mg dose taken 12 h prior to the second dose. Sweat rate was measured during each of the three exercise bouts using a Macroduct® sweat collector affixed to the flexor sur... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2760602 Wed, 02 Sep 2009 23:00:00 +0100 2760602 Influence of long-term oxygen therapy on heart rate and QT time-series in hypoxic patients with chronic obstructive pulmonary disease http://www.medworm.com/index.php?rid=2747039&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00891.x Conclusions: An increase in HRV following LTOT (but notably in the absence of altered activity levels) provides tentative evidence that LTOT has a direct effect on heart rate control in COPD. This beneficial influence was expressed mainly during the morning, and the relevance of this diurnal variation in response requires further investigation. It was also confirmed that both RR and (to a lesser degree) QT time-series in COPD have a multifractal structure, and this is not affected appreciably by LTOT. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2747039 Sun, 30 Aug 2009 23:00:00 +0100 2747039 Long-term prognostic role of coronary flow velocity reserve in patients with aortic valve stenosis – insights from the SZEGED Study http://www.medworm.com/index.php?rid=2740043&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00893.x Introduction: Coronary flow velocity reserve (CFR) is markedly reduced in severe aortic valve stenosis (AS). Independent prognostic value of pulsed-wave Doppler echocardiography-derived CFR was seen in a variety of diseases. However, the prognostic significance of CFR by pulsed-wave Doppler echocardiography has never been evaluated in patients with AS.Methods: A total of 49 AS patients (mean age: 63 ± 9 years, 26 men) were enrolled in this prospective follow-up study; they all had undergone standard transthoracic Doppler-echo study, coronary angiography and dipyridamole stress transoesophageal echocardiography as CFR measurement.Results: During a mean follow-up of 82 ± 38 months, 18 patients suffered cardiovascular death and one patient had non-fatal stroke. Other two patients underwent ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2740043 Thu, 27 Aug 2009 23:00:00 +0100 2740043 Asystole and increased serum myoglobin levels associated with 'packing blackout' in a competitive breath-hold diver http://www.medworm.com/index.php?rid=2732717&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00892.x We report a case with a breath-hold diver who inadvertently experienced a packing blackout. During the incident, an electrocardiogram (ECG) and blood pressure were recorded, and blood samples for determinations of biomarkers of cardiac muscle perturbation (creatine kinase-MB isoenzyme (CK-MB), cardiac troponin-T (TnT), and myoglobin) were collected. The ECG revealed short periods of asystole during the period of 'packing blackout', simultaneous with pronounced reductions in systolic, diastolic, and pulse pressures. Serum myoglobin concentration was elevated 40 and 150 min after the incident, whereas there were no changes in CK-MB or TnT. The ultimate cause of syncope in this diver probably was a decrease in cerebral perfusion following glossopharyngeal insufflation. The asystolic periods r... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2732717 Tue, 25 Aug 2009 23:00:00 +0100 2732717 Adaptation of the Threshold IMT® with double spring load allows higher inspiratory pressure for muscle training http://www.medworm.com/index.php?rid=2669715&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00888.x Conclusion: The Threshold IMT® adaptation proposed here is simple, affordable, precise, safe and allows for a high degree of reproducibility. It also achieves pressures higher than 41 cmH2O that can be used when training inspiratory muscles. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2669715 Tue, 04 Aug 2009 23:00:00 +0100 2669715 Maintained cerebral metabolic ratio during exercise in patients with β-adrenergic blockade http://www.medworm.com/index.php?rid=2652364&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00889.x Background: Decreased cerebral metabolic ratio (CMR) [molar uptake of O2 versus molar uptake of (glucose + ½ lactate)] during exercise is attenuated by intravenous administration of the non-selective [beta]-adrenergic receptor antagonist propranolol. We evaluated to what extent cirrhotic patients in oral treatment with propranolol are able to mobilize brain non-oxidative carbohydrate metabolism.Methods: Incremental cycle ergometry to exhaustion (86 ± 4·2 W; mean ± SD) was performed in eight cirrhotic patients instrumented with a catheter in the brachial artery and one retrograde in the right internal jugular vein. Healthy subjects form the control group.Results: In [beta]-blocked cirrhotic patients arterial lactate increased from 1·5 ± 0·3 to 5·1 ± 0·8 mM (P (Source: Clinical Phy... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2652364 Wed, 29 Jul 2009 23:00:00 +0100 2652364 Early activation of the coagulation system during lower body negative pressure http://www.medworm.com/index.php?rid=2643834&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00890.x In conclusion, thrombin generation was activated by a modest decrease in CBV by LBNP in healthy humans independent of the vagal activity. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2643834 Mon, 27 Jul 2009 23:00:00 +0100 2643834 Semi-quantitative tracking of intra-airway fluids by computed tomography http://www.medworm.com/index.php?rid=2616347&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00885.x Background: Airway secretions are a source of complications for patients with acute and chronic lung diseases, yet lack of techniques to quantitatively track secretions hampers research into clinical measures to reduce their pathologic consequences.Methods: In a preserved swine lung model, we tracked a contrasted mucus simulant (CMS) using sequential computed tomography (CT). Known drivers of secretion movement [ndash] gravity and ventilation [ndash] were tested. Ten millilitres of CMS were unilaterally introduced (1 ml min[minus]1) into the airways of 12 lung sets. After instillation, six lung sets were maintained prone and six were rotated 180°. Subsequently, all were mechanically ventilated for 10 min. CTs were obtained before infusion, after infusion and after ventilation ± rotation.... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2616347 Sun, 19 Jul 2009 23:00:00 +0100 2616347 Blood flow rate measurements with indicator techniques revisited http://www.medworm.com/index.php?rid=2616346&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00886.x In view of the emerging role, disturbances in regional blood flow rate seem to play in the pathogenesis of the metabolic syndrome; we review the concepts of the classical indicator dilution and washout techniques used for determinations of regional blood flow rate. Prerequisites, assumptions, necessary precautions for the application of these experimental techniques are emphasized. Special attention has been carried out to elucidate the consequence of a choice of indicators having a large distribution volume in the tissues. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2616346 Sun, 19 Jul 2009 23:00:00 +0100 2616346 Cardiac sympathetic activity is associated with inflammation and neurohumoral activation in patients with idiopathic dilated cardiomyopathy http://www.medworm.com/index.php?rid=2616348&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00887.x Background: Idiopathic dilated cardiomyopathy (IDC) is characterized by sympathetic nervous overactivity, inflammation and neurohumoral activation; however, their interrelationships are poorly understood.Methods and results: We studied 99 patients with IDC (age 54 ± 1 years, left ventricular ejection fraction (EF) 40 ± 1%, maximum oxygen uptake (VO2max) 20 ± 1 ml kg[minus]1 min[minus]2, mean ± SEM) by using 123I-metaiodobenzylguanidine (MIBG) imaging. MIBG washout and MIBG heart/mediastinum (H/M)-ratio at 4 h postinjection were calculated. In addition, the plasma levels of interleukin (IL)-6 and N-terminal B-type natriuretic peptide (NT-proBNP) were measured. MIBG washout and MIBG H/M ratio had a significant correlation with IL-6 (r = 0·42, P (Source: Clinical Physiology and Functiona... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2616348 Sat, 18 Jul 2009 23:00:00 +0100 2616348 Respiratory muscle strength and muscle endurance are not affected by acute metabolic acidemia http://www.medworm.com/index.php?rid=2604626&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00878.x In this study, the effect of metabolic acidosis was studied on peripheral muscle strength, peripheral muscle endurance, airway resistance, and on arterial carbon dioxide tension (PaCO2). Acute metabolic acidosis was induced by administration of ammonium chloride (NH4Cl). The effect of metabolic acidosis was studied on inspiratory and expiratory muscle strength and on respiratory muscle endurance. Effects were studied in a randomized, placebo-controlled cross-over design in 15 healthy subjects (4 male; age 33·2 ± 11·5 years; FEV1 108·3 ± 16·2% predicted), 14 asthma patients (5 male; age 48·1 ± 16·1 years; FEV1 101·6 ± 15·3% predicted), and 15 moderate to severe COPD patients (9 male; age 62·8 ± 6·8 years; FEV1 50·0 ± 11·8% predicted). An acute metabolic acidemia of BE [nda... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2604626 Wed, 15 Jul 2009 23:00:00 +0100 2604626 Gender differences in circulating bubble production after SCUBA diving http://www.medworm.com/index.php?rid=2572514&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00884.x Objective: Differences in circulating bubble production have been described after exposures in altitude chambers between men and women. The present study was designed to examine gender differences in circulating bubble production after a dive.Methods: Fifty-two men and 52 women performed the same dive profile (25 min to 35 m). Circulating bubbles were detected by continuous wave Doppler. Tests were conducted at sea in a boat, at 10-min intervals for 1 h after surfacing. Signals were graded according to the Spencer scale. The categorical data were then converted to a single number reflecting total bubble activity using the KISS index.Results: Considering each measurement period, bubble grade was higher in men than women 30, 40 and 50 min postdive. On the contrary, bubble grade was comparabl... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2572514 Sun, 05 Jul 2009 23:00:00 +0100 2572514 Evaluation of endothelial function using finger plethysmography http://www.medworm.com/index.php?rid=2495598&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00882.x Conclusion: Maximum response was reached after 5 min of blood flow occlusion and therefore this occlusion time is recommended. The response after forearm and upper-arm occlusion did not differ significantly. Forearm occlusion might be preferred as this caused less discomfort. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2495598 Wed, 24 Jun 2009 23:00:00 +0100 2495598 Long-term changes in dynamic cerebral autoregulation: a 10 years follow up study http://www.medworm.com/index.php?rid=2495599&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00880.x This study takes a novel approach to describing time-related changes in dynamic cerebral autoregulation (dCA). It is well-recognized that dCA exhibits both intra- and inter- subject variability, and this study seeks to characterize the extent to which intra-subject variability occurs after a significant period of time by studying the same subjects 10 years apart, thus eliminating inter-subject variability as a source of error. Ten healthy subjects were identified in 1998 and followed up in 2008. On each visit they underwent simultaneous recordings of right middle cerebral artery cerebral blood flow velocity (RMCA CBFV), blood pressure and heart rate. Data were analysed in the frequency domain using transfer function analysis and in the time domain using CBFV step response, from which the a... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2495599 Sun, 21 Jun 2009 23:00:00 +0100 2495599 Alterations in forearm position and environmental temperature influences the segmental volume expansion during venous occlusion plethysmography – special attention on hand circulation http://www.medworm.com/index.php?rid=2482746&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00883.x Aim: To find evidence that small changes in the positioning of the strain gauge, the environmental temperature (sympathetic activation) and position of the arm (venous pressure) alters the outcome of the venous occlusion plethysmography (VOP) measurement of forearm blood flow and to investigate if the hand circulation influences the results.Methods: Forearm blood flow was measured with VOP (n = 6) on three occasions with air temperatures of 13, 20 and 38°C, respectively. At each occasion the arm position was varied; raised by 10°, horizontal or lowered by 15°. Strain gauges were placed on the forearm at the maximal circumference; 5 cm distal; and 5 cm proximal to this site, respectively. The hand circulation was excluded in half of the measurements.Results: The simple main effect of tem... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2482746 Wed, 17 Jun 2009 04:00:00 +0100 2482746 Giant cell arteritis on 18F-FDG PET/CT http://www.medworm.com/index.php?rid=2482747&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00881.x Conclusion: Increased 18F-FDG uptake by the aorta on PET/CT imaging is an abnormal finding that prompts a more thorough assessment for malignancy, and also can indentify important co-morbidities in cancer patients. Evaluation of aortic uptake should be a routine practice in the interpretation of 18F-FDG PET/CT scans. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2482747 Fri, 12 Jun 2009 04:00:00 +0100 2482747 Brachial artery hyperemic blood flow velocities are related to carotid atherosclerosis http://www.medworm.com/index.php?rid=2466696&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00879.x Conclusion: Our results indicate that the hyperemic systolic to diastolic blood flow velocity ratio in the brachial artery is related to atherosclerosis in the carotid artery. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2466696 Tue, 09 Jun 2009 04:00:00 +0100 2466696 Flow mediated vasodilation and circulating concentrations of high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-α in normal pregnancy – The Cardiovascular Risk in Young Finns Study http://www.medworm.com/index.php?rid=2453367&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00877.x Background: Traditional risk factors such as hyperlipidemia induce a state of inflammation that impairs vascular function. Despite marked maternal hyperlipidemia, endothelial function improves during pregnancy. In non-pregnant state increased circulating levels of pro-inflammatory cytokines and high sensitive C-reactive protein (hsCRP) lead to attenuated flow mediated vasodilation. Relation between endothelial function and pro-inflammatory cytokines has not been studied thoroughly in pregnancy. The aim of this study was to evaluate the effect of pregnancy on hsCRP and pro-inflammatory cytokines and their associations with vascular endothelial function.Methods: As part of population-based, prospective cohort Cardiovascular Risk in Young Finns study conducted in Finland we measured brachial ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2453367 Fri, 05 Jun 2009 04:00:00 +0100 2453367 Atherosclerosis measured by whole body magnetic resonance angiography and carotid artery ultrasound is related to arterial compliance, but not to endothelium-dependent vasodilation – the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study http://www.medworm.com/index.php?rid=2430764&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00871.x Background: Arterial compliance and endothelium-dependent vasodilation are two characteristics of the vessel wall. In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, we studied the relationships between arterial compliance and endothelium-dependent vasodilation versus atherosclerosis as measured with two imaging modalities.Methods: In the population-based PIVUS study (1016 subjects aged 70), arterial compliance was determined by ultrasound in the carotid artery and the stroke volume to pulse pressure ratio by echocardiography, while endothelium-dependent vasodilation was assessed by the invasive forearm technique with acetylcholine and brachial artery ultrasound. Intima-media thickness was evaluated by ultrasound in the carotid artery (n = 954). Stenosis ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2430764 Sun, 24 May 2009 04:00:00 +0100 2430764 Tracer kinetics analysis of dynamic contrast-enhanced CT and MR data in patients with squamous cell carcinoma of the upper aerodigestive tract: comparison of the results http://www.medworm.com/index.php?rid=2410469&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00876.x Conclusion: The estimation of functional parameters in SCCA is feasible using DCE-CT and -MR with a DP model. The parameters are mostly significantly different and the interchangeability of them is limited. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2410469 Fri, 15 May 2009 04:00:00 +0100 2410469 Intensity of Nordic Walking in young females with different peak O2 consumption http://www.medworm.com/index.php?rid=2410470&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00872.x The purpose of this cross-sectional study was to determine the physiological reaction to the different intensity Nordic Walking exercise in young females with different aerobic capacity values. Twenty-eight 19[ndash]24-year-old female university students participated in the study. Their peak O2 consumption (VO2 peak kg[minus]1) and individual ventilatory threshold (IVT) were measured using a continuous incremental protocol until volitional exhaustion on treadmill. The subjects were analysed as a whole group (n = 28) and were also divided into three groups based on the measured VO2 peak kg[minus]1 (Difference between groups is 1 SD) as follows: 1. >46 ml min[minus]1 kg[minus]1 (n = 8), 2. 41[ndash]46 ml min[minus]1 kg[minus]1 (n = 12) and 3. 0·05). However, during maximal speed walking, th... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2410470 Thu, 14 May 2009 04:00:00 +0100 2410470 Effects of adrenaline on longitudinal arterial wall movements and resulting intramural shear strain: a first report http://www.medworm.com/index.php?rid=2394849&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00875.x Using ultrasound we recently demonstrated that in central elastic arteries as well as in large muscular arteries in humans there is a distinct longitudinal displacement of the arterial wall during the cardiac cycle. Further, for the first time, we also demonstrated that the inner parts of the vessel wall, the intima-media complex, in these vessels exhibit a larger longitudinal displacement than the outer part of the vessel wall, the adventitial region, introducing the presence of substantial shear strain, and thus shear stress within the vessel wall. The role of these unexplored phenomena is unknown. Here, in a first study on the longitudinal movements of the porcine common carotid artery, we show that administration of adrenaline (epinephrine) might have pronounced effects on the longitud... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2394849 Thu, 07 May 2009 04:00:00 +0100 2394849 Heart rate variability during sleep and sleep apnoea in a population based study of 387 women http://www.medworm.com/index.php?rid=2379001&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00873.x Increased sympathetic activity during sleep has been suggested as a link between obstructive sleep apnoea syndrome and cardiovascular disease. Heart rate variability (HRV) is a measure of autonomic effect on the heart. Different parameters have been associated with sympathetic and parasympathetic activity. We have studied HRV in different sleep stages and related the HRV-pattern to sleep apnoea in a population-based sample of 387 women. We investigated the HRV-parameters standard deviation of all R-R intervals (SDNN), root of the averaged square of successive differences (RMSSD), low frequency component (LF), high frequency component (HF), ratio of low frequency component to high frequency component LF/HF and VSAI [variation in sympathetic activity between rapid eye movement (REM) and slow... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2379001 Thu, 30 Apr 2009 04:00:00 +0100 2379001 Breathing patterns during progressive incremental cycle and treadmill exercise are different http://www.medworm.com/index.php?rid=2362338&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00874.x Perceived breathlessness at comparable minute ventilation (VE) is higher with cycling than with running. Different use of the upper extremities and chest wall may influence the breathing pattern. It was hypothetized that the relationship between tidal volume (VT) and VE throughout progressive incremental exercise is different with the two modes of exercise. Twelve well trained subjects (seven men) 20[ndash]25 years had incremental maximal exercise tests on a treadmill and a cycle ergometer on different days in random order. Heart rate, respiratory gases, VE and VT were measured on a computerized exercise testing system, and data were averaged over 20 s periods. The VE[minus]VT relationship was characterized by maximum VT, VT at a VE of 30 l min[minus]1 (VT30), the Hey plot and by a least s... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2362338 Fri, 24 Apr 2009 04:00:00 +0100 2362338 Acute effects of sustained isometric knee extension on cerebral and muscle oxygenation responses http://www.medworm.com/index.php?rid=2317575&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00870.x Cerebral contra-lateral frontal lobe and the dominant vastus lateralis muscle oxygenation (Cox, Mox) and blood volume (Cbv, Mbv) were recorded simultaneously using near infrared spectroscopy (NIRS) in 12 healthy volunteers (37·4 ± 9·9 years; 72·3 ± 16·1 kg; 171·0 ± 9·6 cm) during 2 min resting baseline, an isometric knee extension with the 1 RM load sustained to the point of fatigue, and 3 min recovery. The mean exercise duration was 19·1 ± 2·6 s. During the contraction, Cox and Cbv increased systematically with no sign of levelling off until the point of fatigue. In contrast, Mox and Mbv declined continuously until the termination of exercise. Qualitative analysis of these NIRS profiles suggested that maximal isometric performance under normoxic conditions was most likely not ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2317575 Thu, 09 Apr 2009 04:00:00 +0100 2317575 A preliminary investigation into the effect of coffee on hypolagesia associated with transcutaneous electrical nerve stimulation http://www.medworm.com/index.php?rid=2317578&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00869.x Transcutaneous electrical nerve stimulation (TENS) is a non-invasive, inexpensive analgesic technique used to relieve pain. It has been suggested that caffeine, an adenosine antagonist, may interfere with TENS action. This double-blind controlled pilot study investigated the effect of coffee on response to TENS in healthy human participants experiencing experimentally induced pain. Twelve participants (7 female, age range = 20[ndash]41 years) took part in two experiments separated by 24 h. Each experiment lasted 80 min and consisted of 3 × 15 min cycles: pre-TENS, during TENS predrink and during TENS postdrink [coffee (100 mg caffeine) or decaffeinated coffee randomized across experiments]. During each cycle, thresholds for electrical (EPT), mechanical (MPT) and cold pressor (CPT) pain we... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2317578 Thu, 02 Apr 2009 04:00:00 +0100 2317578 Rowing, the ultimate challenge to the human body – implications for physiological variables http://www.medworm.com/index.php?rid=2317577&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00867.x Clinical diagnoses depend on a variety of physiological variables but the full range of these variables is seldom known. With the load placed on the human body during competitive rowing, the physiological range for several variables is illustrated. The extreme work produced during rowing is explained by the seated position and the associated ability to increase venous return and, thus, cardiac output. This review highlights experimental work on Olympic rowing that presents a unique challenge to the human capacities, including cerebral metabolism, to unprecedented limits, and provides a unique opportunity to reveal the extreme range of many physiological variables. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2317577 Thu, 02 Apr 2009 04:00:00 +0100 2317577 Femoral artery blood flow and its relationship to spontaneous fluctuations in rhythmic thigh muscle workload http://www.medworm.com/index.php?rid=2317580&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00868.x Background and aim: Limb femoral arterial blood flow (LBF) is known to increase linearly with increasing workload under steady-state conditions, suggesting a close link between LBF and metabolic activity. We, however, hypothesized that sudden physiological and spontaneous changes in exercise rhythm, and consequently workload temporarily alter blood flow to the working muscle. LBF and its relation to fluctuations in the contraction rhythm and workload were therefore investigated.Methods: LBF, measured by Doppler ultrasound, and the achieved workload, were continuously measured in nine subjects, aiming to perform steady-state, one-legged, dynamic knee-extensor exercise at 30 and 60 contractions per minute (cpm), at incremental target workloads of 10, 20, 30 and 40 W.Results: In agreement wit... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2317580 Mon, 30 Mar 2009 04:00:00 +0100 2317580 Inert gas rebreathing: the effect of haemoglobin based pulmonary shunt flow correction on the accuracy of cardiac output measurements in clinical practice http://www.medworm.com/index.php?rid=2271487&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00861.x Background: Cardiac output (CO) is an important cardiac parameter, however its determination is difficult in clinical routine. Non-invasive inert gas rebreathing (IGR) measurements yielded promising results in recent studies. It directly measures pulmonary blood flow (PBF) which equals CO in absence of significant pulmonary shunt flow (QS). A reliable shunt correction requiring the haemoglobin concentration (cHb) as only value to be entered manually has been implemented. Therefore, the aim of the study was to evaluate the effect of various approaches to QS correction on the accuracy of IGR.Methods: Cardiac output determined by cardiac magnetic resonance imaging (CMR) served as reference values. The data was analysed in four groups: PBF without correcting for QS (group A), shunt correction ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2271487 Tue, 17 Mar 2009 04:00:00 +0100 2271487 Cardiac magnetic resonance imaging in valvular heart disease http://www.medworm.com/index.php?rid=2254092&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00865.x Cardiac magnetic resonance imaging (CMR) has rapidly gained acceptance as an accurate, reproducible and non-invasive imaging method for assessment of a wide range of cardiovascular diseases. However, CMR has not been used widely for diagnostic purposes in valvular heart disease (VHD). Unlike echocardiography it has no body habitus-related limitations and can thus be used to complement echocardiography. It is an especially good alternative for clinical follow-up in patients with VHD, as it allows accurate measurement of valvular dysfunction and related ventricular burden. Additionally, CMR is an ideal method for evaluating complex congenital heart disease and determining the significance of its components. It can also be used to study the physiological course of valvular dysfunction and res... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2254092 Wed, 11 Mar 2009 04:00:00 +0100 2254092 Effects of detraining on muscle strength and mass after high or moderate intensity of resistance training in older adults http://www.medworm.com/index.php?rid=2254093&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00866.x This study examined the effects of a 12 weeks detraining period on muscle strength and mass in older adults who had previously participated in a 12 weeks resistance training programme of high [80% of one repetition maximum (1-RM)] or moderate (60% of 1-RM) intensity. Twenty older adults (60[ndash]74 years), separated into a high (HI; n = 10; age: 65 ± 5 years) and a moderate (MI; n = 10; age: 66 ± 4 years) intensity resistance training group, were measured in the 1-RM knee extension and flexion strength, and the midthigh cross sectional areas (CSAs) of quadriceps, hamstrings and total thigh before and after a 12 weeks training period as well as after a 12 weeks detraining period. Maximum knee extension and flexion strength and the CSAs of all muscles decreased significantly (P (Source: C... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2254093 Tue, 10 Mar 2009 04:00:00 +0100 2254093 The role of nitric oxide- and prostacyclin-independent vasodilatation in the human cutaneous microcirculation: effect of cytochrome P450 2C9 inhibition http://www.medworm.com/index.php?rid=2254094&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00862.x The component of the flow- or agonist-dependent vasodilatation, insensitive to inhibitors of nitric oxide (NO) synthases (NOS) or cyclooxygenases (COX), is suggested to reflect the production of an endothelium-dependent hyperpolarizing factor (EDHF). The identity of EDHF in humans remains controversial; in coronary arterioles, it appears to be a cytochrome P450 (CYP) 2C9-derived metabolite, whereas there are no data for human skin microcirculation. Therefore, the aim of our study was to investigate the role of the NO- and prostacyclin (PGI2)-independent mechanism, particularly the potential involvement of CYP 2C9, in skin microcirculation. We measured skin blood flow on the volar aspect of the forearm in 12 healthy subjects by laser-Doppler fluxmetry (LDF). The inhibitors of NOS, N[omega]-... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2254094 Sun, 08 Mar 2009 05:00:00 +0100 2254094 Differences between smooth pursuit and optokinetic eye movements using limited lifetime dot stimulation: a functional magnetic resonance imaging study http://www.medworm.com/index.php?rid=2238614&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00858.x In this study, we examined possible differences in brain activation between smooth pursuit and optokinetic reflexive (OKR) eye movements using functional magnetic resonance imaging (fMRI). Eighteen healthy subjects performed two different eye movement paradigms. In the first paradigm, smooth pursuit eye movements were evoked by a single moving dot. In the second paradigm, optokinetic eye movements without a foveal smooth pursuit component were evoked by a moving pattern of multiple dots with a limited lifetime. As expected, the two eye movement systems show overlapping pathways, but the direct comparison of the activation patterns between the two experiments showed that the frontal eye field, MT/V5 and cerebellar area VI appear to be more activated during smooth pursuit than during optokin... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2238614 Fri, 06 Mar 2009 05:00:00 +0100 2238614 Maximal explosive muscle power in obese and non-obese prepubertal children http://www.medworm.com/index.php?rid=2231110&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00863.x The objectives of the present study was to compare the maximal explosive muscle power developed by the lower limbs in obese and non-obese prepubertal children.Design: Twenty-five obese [mean body mass index (BMI) z-score: 2·4] and 30 non-obese (mean BMI z-score: 0) children aged 8[ndash]12 years, participated in this study. Body composition was measured by bioelectrical impedance analysis and the maximal explosive power of the lower limbs was assessed by the Exercise-Ergometer (a sledge dynamometer).Results: Absolute peak force (Fpeak) was higher in obese than in non-obese children by 18·2% (P (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2231110 Wed, 04 Mar 2009 05:00:00 +0100 2231110 Test–retest reliability of the IDEEA system in the quantification of step parameters during walking and stair climbing http://www.medworm.com/index.php?rid=2231111&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00864.x The aim of this investigation was to evaluate the inter- and intra-session reliability of spatio-temporal gait variables collected during walking and stair climbing with the Intelligent Device for Energy Expenditure and physical Activity (IDEEA) accelerometer-based system. Eighteen healthy subjects (10 men, 8 women) completed a standardized indoor circuit comprised of walking and stair climbing. Intra-and inter-session reliability was investigated for several pertinent spatio-temporal gait variables using intraclass correlations [ICC (3,1)]. Intra-session reliability during walking showed a high reliability of the IDEEA with ICCs ranging between 0·84 (number of steps) and 0·97 (single limb support/double limb support). The ICCs for stair climbing were slightly lower than those during wal... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2231111 Mon, 02 Mar 2009 05:00:00 +0100 2231111 Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction http://www.medworm.com/index.php?rid=2226477&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00857.x Conclusions: Differential index and other indices of HRV are stable and reproducible in patients with chronic stable angina pectoris. High-frequency HRV (reflecting cardiac parasympathetic activity) and the differential index changed little following an acute coronary event, and may be suitable for predictions of the future risk of sudden death even in the presence of a recent acute coronary event. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2226477 Mon, 02 Mar 2009 05:00:00 +0100 2226477 Differences in myocardial velocities during supine and upright exercise stress echocardiography in healthy adults http://www.medworm.com/index.php?rid=2226476&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00860.x Background: Tissue Velocity Imaging (TVI) is a method for quantitative analysis of longitudinal myocardial velocities, which can be used during exercise and pharmacological stress echocardiography. It is of interest to evaluate cardiac response to different types of stress tests and the differences between upright and supine bicycle exercise tests have not been fully investigated. Therefore, the aim of this study was to compare cardiac response during supine and upright exercise stress tests.Method: Twenty young healthy individuals underwent supine and upright stress test. The initial workload was set to 30 W and was increased every minute by a further 30 W until physical exhaustion. Tissue Doppler data from the left ventricle were acquired at the end of every workload level using a GE Viv... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2226476 Mon, 02 Mar 2009 05:00:00 +0100 2226476 Antegrade pulsatile arterial-like flow in human limb veins at increased intravascular pressure http://www.medworm.com/index.php?rid=2198931&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00859.x Conclusion: That pulsatile flow was observed in all veins may suggest that moderately to markedly elevated intravascular pressures induce propagation of pulse waves from the arteries via the capillaries to the veins, and/or induce considerable arteriovenous shunting, by forcing open arteriovenous anastomoses. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2198931 Fri, 20 Feb 2009 05:00:00 +0100 2198931 Influence of arterial wave reflection on carotid blood pressure and intima-media thickness in older endurance trained men and women with pre-hypertension http://www.medworm.com/index.php?rid=2198932&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2009.00856.x Increased carotid intima-media thickness (IMT) with aging is a significant predictor of mortality. Older endurance trained (ET) individuals have lower carotid artery stiffness but similar carotid IMT when compared to sedentary (SED) age-matched peers. The purpose of this study was to examine the contribution of arterial wave reflections to carotid hemodynamics and IMT in older ET and SED with pre-hypertension. Subjects consisted of endurance-trained master athletes and age-matched sedentary controls (mean age 67 years). Carotid artery Beta-stiffness index and IMT was assessed with ultrasonography. Carotid pressure and augmented pressure from wave reflections (obtained from pulse contour analysis) was measured with applanation tonometry. Carotid systolic blood pressure (SBP) and IMT were no... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2198932 Thu, 19 Feb 2009 05:00:00 +0100 2198932 Changes in left ventricular ejection time and pulse transit time derived from finger photoplethysmogram and electrocardiogram during moderate haemorrhage http://www.medworm.com/index.php?rid=2128014&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00843.x This study explored the potential use of the finger photoplethysmographic (PPG) waveform derived left ventricular ejection time (LVETp) and pulse transit time (PTT) for detecting blood loss, by using blood donation as a model of controlled mild to moderate haemorrhage.Methods: This was a prospective, observational study carried out in a convenience sample of blood donors. LVETp, PTT and R-R interval (RRi) were computed from simultaneous measurement of the electrocardiogram (ECG) and the finger infrared photoplethysmogram obtained from 43 healthy volunteers during blood donation. The blood donation process was divided into four stages: (i) Pre-donation (PRE), (ii) first half of donation (FIRST), (iii) second half of donation (SECOND), (iv) post-donation (POST).Results and conclusions: Short... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2128014 Fri, 23 Jan 2009 05:00:00 +0100 2128014 Effect of nebivolol on blood oxygen transport indices and endothelial dysfunction in patients with arterial hypertension http://www.medworm.com/index.php?rid=2115003&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00852.x Endothelial dysfunction, which is characterized by impairment of nitric oxide (NO) bioavailability, plays an important role in the development of arterial hypertension. The L-arginine-NO pathway is closely related to oxygen transport to tissue. Endothelial dysfunction in patients with arterial hypertension can affect haemoglobin-oxygen affinity and tissue oxygen supply. Alterations in blood oxygen transport indices may play role in the pathogenesis of arterial hypertension. The aim of the present study was to investigate the effect of the beta-selective adrenoblocker nebilet (nebivolol) on blood oxygen transport indices and on endothelial dysfunction in patients with arterial hypertension. The study population included 52 patients with grade II and grade III arterial hypertension. The resu... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2115003 Mon, 19 Jan 2009 05:00:00 +0100 2115003 Experimental case report: development of a pneumothorax monitored by electrical impedance tomography http://www.medworm.com/index.php?rid=2107186&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00855.x We report an incident of an accidental tension pneumothorax during an experimental ventilation study in a pig that was continuously monitored by EIT. The early sign of the occurring pneumothorax, prior to all clinical signs, was a fast increase of end-expiratory impedance in the ventral part of the right lung indicating that non-ventilated air entered this part, followed by a disappearance of ventilation in this region. At the same time the ventilation-related impedance changes of the left lung remained almost unchanged. The pneumothorax onset was localized using a newly introduced pneumothorax dynamics map directly derived from dynamic EIT data. We conclude that non-invasive EIT may be helpful as a tool to detect the development of a pneumothorax, which could be of particular interest dur... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2107186 Fri, 16 Jan 2009 05:00:00 +0100 2107186 A new ventilatory threshold equation for aerobically trained men and women http://www.medworm.com/index.php?rid=2107188&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00850.x The purposes of the present study were to (i) modify previously published ventilatory threshold (VT) equations using the constant error (CE) values for aerobically trained individuals from a recent study; (ii) cross-validate the modified equations to determine their accuracy for estimating VT in aerobically trained individuals; (iii) derive a new non-exercise based equation for estimating VT in aerobically trained individuals if the modified equations are found to be inaccurate; and (iv) cross-validate the new VT equation using the Predicted REsidual Sum of Squares (PRESS) statistic and an independent sample of aerobically trained individuals. Two hundred and eight (n = 208) aerobically trained men and women (mean ± SD: age = 38·8 ± 10·4 year) performed a maximal incremental test on a ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2107188 Thu, 15 Jan 2009 05:00:00 +0100 2107188 Determination of the mitral papillary muscle positions by the septal-to-free wall arc ratio method http://www.medworm.com/index.php?rid=2107187&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00853.x Conclusions: The SFAR method may be applied in wide range of both scientific and clinical medical fields as a reproducible method for determination of papillary muscle positions with the benefit of estimation of relative papillary muscle positions both from the septum and the free wall. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2107187 Thu, 15 Jan 2009 05:00:00 +0100 2107187 Relationships between plasma adrenomedullin concentration and systolic time intervals during static handgrip in patients with heart failure http://www.medworm.com/index.php?rid=2072421&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00842.x Our previous study showed elevation of plasma adrenomedullin (ADM) during static handgrip in patients with heart failure (HF). It is hypothesized that ADM increases with left ventricle dysfunction during handgrip and thus plays a compensatory role. In the present study pre-ejection period (PEP) and left ventricular ejection time (LVET) were used to assess cardiac performance in 24 male HF patients (II/III class NYHA) during two 3-min bouts of handgrip at 30% of maximal voluntary contraction (MVC) performed alternately with each hand without any break between the bouts. Plasma ADM, noradrenaline (NA), adrenaline (A), heart rate (HR), blood pressure (BP) and stroke volume (SV) were determined. During handgrip plasma ADM, NA, A, HR, BP, PEP/LVET increased, PEP was prolonged and LVET shortened... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2072421 Sat, 03 Jan 2009 05:00:00 +0100 2072421 Low-intensity resistance training with slow movement and tonic force generation increases basal limb blood flow http://www.medworm.com/index.php?rid=2072422&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00847.x Metabolic syndrome is associated with reductions in basal limb blood flow. Resistance training increasing muscle mass and strength increases basal limb blood flow. Low-intensity resistance exercise with slow movement and tonic force generation (LST) has been proposed as one of the effective methods of resistance training increasing muscle mass and strength. The hypothesis that LST training increases basal femoral blood flow as well as traditional high-intensity resistance training at normal speed (HN) was examined. Thirty-six healthy young men without a history of regular resistance training were randomly assigned to the LST [[sim]55[ndash]60% one repetition maximum (1RM) load, 3 s lifting and 3 s lowering with no relaxation phase, n = 12], HN ([sim]85[ndash]90% 1RM, 1 s lifting and 1 s lo... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2072422 Thu, 01 Jan 2009 05:00:00 +0100 2072422 Small animal PET for the evaluation of an animal model of genital infection http://www.medworm.com/index.php?rid=2072424&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00854.x Conclusion: 68Ga-Chloride is a promising tracer for the assessment of genital infection in a mouse animal model. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2072424 Tue, 30 Dec 2008 05:00:00 +0100 2072424 Echocardiography in Fabry disease: diagnostic value of endocardial border binary appearance http://www.medworm.com/index.php?rid=2072423&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00851.x Conclusions: Binary appearance of the endocardium is not feasible for screening Fabry disease by echocardiography. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2072423 Tue, 30 Dec 2008 05:00:00 +0100 2072423 Detection of single-vessel coronary artery disease by dipyridamole stress echocardiography: no longer a problem? http://www.medworm.com/index.php?rid=2025536&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00849.x Conclusions Addition of MCE perfusion analysis during stress echocardiographical examination based on evaluation of inducible abnormalities improves the test sensitivity for detection of svCAD. This benefit is less apparent when fixed WMA and perfusion defects are incorporated into the stress test positivity criterion. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2025536 Thu, 11 Dec 2008 05:00:00 +0100 2025536 Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation of the exini heart software package http://www.medworm.com/index.php?rid=2025541&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00840.x The aim of the study was to validate the accuracy of the exini heart software (exini) package in assessing left ventricular end-diastolic/systolic volumes (EDV, ESV) and ejection fraction (LVEF) from gated 99mTc-MIBI single-photon emission tomography (SPECT). Cardiac magnetic resonance imaging (cMRI) was used as reference. Furthermore, effects of perfusion defects and image quality in SPECT on correlation between gated SPECT and magnetic resonance imaging were investigated.Methods: Seventy patients were examined using gated SPECT (rest study, eight gates per cardiac cycle). EDV, ESV and LVEF were calculated from gated SPECT using exini. Directly before or after SPECT, cMRI (20 gates cardiac per cycle) was performed. EDV, ESV and LVEF were calculated using Simpson's rule. Perfusion defects ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2025541 Wed, 10 Dec 2008 05:00:00 +0100 2025541 Suitability of single tissue dielectric constant measurements to assess local tissue water in normal and lymphedematous skin http://www.medworm.com/index.php?rid=2025540&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00844.x Previous reports described the use of average tissue dielectric constant (TDC) measurements to assess local tissue water and its change. Our goal was to determine if a single TDC measurement could be used in place of the average of multiple measurements. The comparison criteria used to test this was the extent to which single and averaged measurements yielded similar TDC values in both normal and lymphedematous tissue. Measurements were made in two groups of women; a control group (n = 20) and a group with unilateral arm lymphedema (n = 10). In the control group, TDC was measured to multiple depths (0·5[ndash]5·0 mm) on both ventral forearms and to a depth of 2·5 mm on the lateral thorax on both body sides. In the lymphedematous group, TDC was measured on both ventral forearms to a dept... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2025540 Wed, 10 Dec 2008 05:00:00 +0100 2025540 Variability and reproducibility of hepatic FDG uptake measured as SUV as well as tissue-to-blood background ratio using positron emission tomography in healthy humans http://www.medworm.com/index.php?rid=2025539&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00846.x Conclusions: In normal subjects hepatic FDG-uptake is high and homogeneous with a low CV% between days. T/B corrected values are largely comparable to SUV values but not superior, probably due to the standardization of procedures and homogeneity of the subjects. The T/B corrected method is theoretically superior in a more inhomogeneous population or when using different scanners and is shown here to be easy to apply. Small ROIs of 10 cm3 are representative with respect to mean FDG uptake in the total liver and reproducibility, but do not identify the max FDG uptake. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2025539 Wed, 10 Dec 2008 05:00:00 +0100 2025539 Effects of tetrahydrobiopterin on venous bubble grade and acute diving-induced changes in cardiovascular function http://www.medworm.com/index.php?rid=2025538&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00845.x Conclusion: This suggests that co-administration of BH4 and vitamin C does not improve heart and pulmonary artery function after diving. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2025538 Wed, 10 Dec 2008 05:00:00 +0100 2025538 Effects of long-term clarithromycin treatment on lavage-fluid markers of inflammation in chronic rhinosinusitis http://www.medworm.com/index.php?rid=2025537&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00848.x Macrolides can be clinically effective in chronic rhinosinusitis (CRS). However, little is known about how these drugs affect pathophysiological features of CRS in vivo. In the present study, patients with CRS were subjected to long-term treatment with clarithromycin. Nasal lavages with and without histamine (40 and 400 [mu]g ml[minus]1) were carried out prior to and late into the treatment period. Histamine was included as a tool to produce plasma exudation, a process known to move free cellular products from the mucosal tissue into the airway lumen thereby enriching nasal surface liquids with such products. Interleukin-8 (IL-8), myeloperoxidase (MPO), eosinophil cationic protein (ECP), [alpha]2-macroglobulin and fucose were monitored as indices of pro-inflammatory cytokine production, ne... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2025537 Wed, 10 Dec 2008 05:00:00 +0100 2025537 Development of a new semi-quantitative non-invasive method for evaluating ventricular stroke work http://www.medworm.com/index.php?rid=2010267&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00841.x Background and aim: Ventricular stroke work (SW) is one of the best indices to evaluate ventricular function, however, the SW monitoring mainly depends on the invasive method with the artery catheter. In this paper, our aim is to develop a new semi-quantitative non-invasive method for evaluating ventricular SW.Methods: The multiple gated cardiac blood pool imaging was done in 25 patients with coronary artery disease and 12 normal controls. A new parameter, the relative stroke work (RSW) of left ventricle, was calculated using an equation derived from the principle of hydrodynamics. The left ventricular SW was analyzed by stroke volume (SV) and mean arterial pressure. Ejected fraction (EF), peak ejected rate (PER) and peak filling rate (PFR) were gotten with the routine software in imaging ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=2010267 Thu, 04 Dec 2008 05:00:00 +0100 2010267 Assessment of the influence of age on the rate of heart rate decline after maximal exercise in non-athletic adult males http://www.medworm.com/index.php?rid=1950954&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00836.x This study investigated the influence of age on heart rate (HR) decline after exercise in non-athletic adult males. One hundred and fourteen adult males (66 young, 25 ± 6·26 years; 48 old, 53 ± 8·54 years) participated in the study. Subjects performed maximum-effort ergometer exercise in incremental stages. HR was measured at rest and continuously monitored during and after exercise. Maximum oxygen uptake (VO2max) was measured during the exercise using respiratory gas analyser. Body mass index (BMI) was computed from weight and height measurements, while rating of perceived exertion (RPE) was obtained immediately after the exercise. Results indicated age differences in the rate of HR decline with the young presenting significantly higher %HR decline (P (Source: Clinical Physiology and ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1950954 Wed, 12 Nov 2008 05:00:00 +0100 1950954 Influence of energy drinks and alcohol on post-exercise heart rate recovery and heart rate variability http://www.medworm.com/index.php?rid=1946188&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00837.x Conclusion: The healthy subjects developed blunted cardiac autonomic modulation after exercising when they had consumed energy drinks mixed with alcohol. Although they did not develop any significant arrhythmia, individuals predisposed to arrhythmia by congenital or other rhythm disorders could have an increased risk for malignant cardiac arrhythmia in similar situations. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1946188 Mon, 10 Nov 2008 05:00:00 +0100 1946188 Low radiation dose imaging of myocardial perfusion and coronary angiography with a hybrid PET/CT scanner http://www.medworm.com/index.php?rid=1937732&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00838.x We report our first experiences with a low dose sequential CTA mode applicable to hybrid imaging.Methods: In the first phase, 10 consecutive cardiac MDCT angiographies were performed with spiral acquisition and compared in terms of image quality and dose with the following 10 patients performed with a new sequential mode. In the second phase, feasibility and radiation dose of a combined 15O-water rest-stress PET perfusion/sequential CTA protocol were assessed in another group of 61 consecutive patients.Results: Mean effective radiation dose was 60% lower in the sequential group than in the spiral group (19·3 versus 7·6 mSv, P (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1937732 Fri, 07 Nov 2008 05:00:00 +0100 1937732 Low-intensity resistance exercise with slow lifting and lowering does not increase noradrenalin and cardiovascular responses http://www.medworm.com/index.php?rid=1927560&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00829.x The aim of this study was to investigate the effect of low-intensity resistance exercise with slow lifting and lowering (LSL) on plasma endothelin-1 (ET-1) and noradrenalin concentrations in young healthy adults. Eight healthy males participated in this study (age 19·0 ± 0·5 years, mean ± SD). The LSL performed the 10 repetitions with 3 s eccentric (lowering phase) and 3 s concentric (lifting phase) muscle actions. The high-intensity resistance exercise with normal lifting and lowering (HNL) performed the 10 repetitions with 1 s eccentric (lowering phase) and 1 s concentric (lifting phase) muscle actions. The load was set to 40% of one repetition maximal (1RM) for LSL and 80% of 1RM for HNL. Plasma ET-1 and noradrenalin concentrations were measured before and after each type of exercis... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1927560 Mon, 03 Nov 2008 05:00:00 +0100 1927560 Alterations in VO2max and the VO2 plateau with manipulation of sampling interval http://www.medworm.com/index.php?rid=1885568&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00835.x Background: The most accepted criterion for confirming attainment of VO2max is a plateau in oxygen consumption (VO2) at VO2max, but its incidence varies.Aims: To compare VO2max and VO2 plateau incidence across various sampling intervals, and to examine predictors of the change in VO2 ([Delta]VO2) at VO2max.Methods: Sedentary, recreationally-active, and endurance-trained subjects (n = 108, age = 24·2 ± 6·2 year) completed incremental exercise on the treadmill or cycle ergometer. Gas exchange data were obtained breath-by-breath and time-averaged every 15, 30, and 60 s. VO2max attainment was verified with the Taylor et al. (1955) criterion ([Delta]VO2 at VO2max [le]2·1 ml kg[minus]1 min[minus]1). Multiple regression was used to examine predictors of [Delta]VO2 at VO2max.Results: VO2 plate... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1885568 Sat, 18 Oct 2008 04:00:00 +0100 1885568 Whole-body vibration dosage alters leg blood flow http://www.medworm.com/index.php?rid=1879151&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00834.x The effect of whole-body vibration dosage on leg blood flow was investigated. Nine healthy young adult males completed a set of 14 random vibration and non-vibration exercise bouts whilst squatting on a Galileo 900 plate. Six vibration frequencies ranging from 5 to 30 Hz (5 Hz increments) were used in combination with a 2·5 mm and 4·5 mm amplitude to produce twelve 1-min vibration bouts. Subjects also completed two 1-min bouts where no vibration was applied. Systolic and diastolic diameters of the common femoral artery and blood cell velocity were measured by an echo Doppler ultrasound in a standing or rest condition prior to the bouts and during and after each bout. Repeated measures MANOVAs were used in the statistical analysis. Compared with the standing condition, the exercise bouts ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1879151 Thu, 16 Oct 2008 04:00:00 +0100 1879151 Abstracts to the XIVth Scandinavian Congress of Clinical Physiology and Nuclear Medicine in Lillehammer, Norway,February 13-15, 2008 http://www.medworm.com/index.php?rid=1862042&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00824.x (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1862042 Thu, 09 Oct 2008 04:00:00 +0100 1862042 Interrupter technique and pressure oscillation analysis during bronchoconstriction in children http://www.medworm.com/index.php?rid=1823616&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00832.x The use of interrupter resistance (Rint) is a feasible method of measuring bronchodilator responsiveness and bronchial hyperresponsiveness in preschool children. It has been suggested that analysis of recorded oscillations of the mouth pressure may provide additional indices of changes in airway mechanics. The aim of our study was to determine whether amplitude or damping properties of oscillations were more sensitive than Rint in describing changes during bronchoconstriction. Data from 44 children (24 boys) who completed tripling dose methacholine (Mch) challenge were analysed. The median (range) age of children was 4·9 (3·1[ndash]6·1 years). In addition to baseline and maximal Rint after Mch [mean (SD) were 0·92 (0·19) and 1·44 (0·35) kPa l[minus]1 s, respectively], obtained from ... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1823616 Thu, 25 Sep 2008 04:00:00 +0100 1823616 Velocity tracking, a new and user independent method for detecting regional function of the left ventricle http://www.medworm.com/index.php?rid=1823617&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00828.x Conclusion: Velocity tracking is a promising technique that provides an easily understandable three-dimensional bull's eye plot for assessment of regional left ventricular longitudinal velocity with great potential for detection of regional dysfunction and myocardial ischaemia. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1823617 Wed, 24 Sep 2008 04:00:00 +0100 1823617 The effect of glibenclamide on acetylcholine and sodium nitroprusside induced vasodilatation in human cutaneous microcirculation http://www.medworm.com/index.php?rid=1823618&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00833.x Objective: KATP channels have an important regulatory role in resting vascular tone and during hypoxia. Their role in endothelium dependent and independent vasodilatation in human skin microcirculation is less known.Methods: We monitored the laser-Doppler (LD) response in 14 healthy male volunteers on the skin of the forearm. In the case of endothelium dependent vasodilatation [acetylcholine (ACh) induced], a saline solution (used as control) or a solution of glibenclamide (KATP channel blocker) were randomly injected each into a distinct measurement site on different forearms followed by the iontophoresis of ACh. In the case of endothelium dependent vasodilatation with the inhibition of prostaglandin production, diclofenac (cyclooxygenase inhibitor) or the combination of diclofenac and gl... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1823618 Tue, 23 Sep 2008 04:00:00 +0100 1823618 Extended NO analysis in a healthy subgroup of a random sample from a Swedish population http://www.medworm.com/index.php?rid=1814710&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00831.x Conclusion: Extended NO analysis is a simple non-invasive tool that gives by far more information than FENO0·05. Based on our results, we suggest that the values for healthy subjects should be considered to fall between the following ranges: FENO0·05, 10[ndash]30 ppb; CawNO, 50[ndash]250 ppb; DawNO, 5[ndash]15 ml s[minus]1; JawNO, 0·8[ndash]1·6 nl s[minus]1; and CANO, 0[ndash]4 ppb. Values outside these intervals indicate the need for further investigation to exclude a state of disease. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1814710 Thu, 18 Sep 2008 04:00:00 +0100 1814710 Abnormal respiratory-related evoked potentials in untreated awake patients with severe obstructive sleep apnoea syndrome http://www.medworm.com/index.php?rid=1802119&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00830.x Conclusions: The cortical processing of airway occlusion-related afferents seems abnormal in untreated patients with severe obstructive sleep apnoea syndrome. This could be either a severity marker and/or an aggravating factor. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1802119 Thu, 18 Sep 2008 04:00:00 +0100 1802119 Oscillometric blood pressure measurement: a simple method in screening for peripheral arterial disease http://www.medworm.com/index.php?rid=1802118&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00826.x Blood pressure at the ankle level is a reliable indicator of peripheral arterial disease (PAD) and the ankle brachial index (ABI) is a useful non-invasive screening tool for the early detection of atherosclerosis. In the first part of the study, systolic blood pressures obtained by oscillometry and plethysmography were compared in 80 subjects referred for possible vascular disease. In the second part of the study, 31 general practitioners enrolled 1258 consecutive patients aged more than 60 years. ABI was estimated by oscillometry. Patients with an ABI lower than 0·9 were referred to the local hospital for standardized measurements. In the first part, oscillometry showed a sensitivity of 97% and a specificity of 62% with a positive and negative predictive value of 71% and 96%, respectivel... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1802118 Thu, 18 Sep 2008 04:00:00 +0100 1802118 Extended NO analysis in a healthy subgroup in of a random sample from a Swedish population http://www.medworm.com/index.php?rid=1802117&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00831.x Conclusion: Extended NO analysis is a simple non-invasive tool that gives by far more information than FENO0·05. Based on our results, we suggest that the values for healthy subjects should be considered to fall between the following ranges: FENO0·05, 10[ndash]30 ppb; CawNO, 50[ndash]250 ppb; DawNO, 5[ndash]15 ml s[minus]1; JawNO, 0·8[ndash]1·6 nl s[minus]1; and CANO, 0[ndash]4 ppb. Values outside these intervals indicate the need for further investigation to exclude a state of disease. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1802117 Thu, 18 Sep 2008 04:00:00 +0100 1802117 Association of findings in flow-volume spirometry with high-resolution computed tomography signs in asbestos-exposed male workers http://www.medworm.com/index.php?rid=1797305&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00827.x Conclusions: HRCT signs showed distinctive patterns in restrictive and obstructive ventilatory impairment. These results can be used to help to analyse the lung function of patients simultaneously exposed to asbestos and smoking, when this relationship requires elucidation. In addition, the results may be helpful in explaining some radiological findings. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1797305 Wed, 17 Sep 2008 04:00:00 +0100 1797305 Relationship of asymmetric dimethylarginine with flow-mediated dilatation in subjests with newly detected severe hypercholesterolemia http://www.medworm.com/index.php?rid=1797306&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00825.x Background: Little is know about the relationship between asymmetric dimethylarginine (ADMA) and percent flow-mediated dilatation (%FMD) in subjects with severe hypercholesterolemia (HH).Aim: The aim the present study was the evaluation of the relationship of ADMA to %FMD, as well as to lipid parameters and other markers of endothelial dysfunction in newly detected subjects with severe HH.Methods: One hundred and twenty asymptomatic patients with severe, newly detected HH and 100 controls were evaluated. The plasma level of ADMA was tested by ELISA and total homocysteine (tHcy) [ndash] through fluid chromatographic analysis. The %FMD was evaluated by the diameter of brachial artery with 7·5 MHz transducer of HP SONOS 5500.Results: Significant difference was found between patients and cont... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1797306 Tue, 16 Sep 2008 04:00:00 +0100 1797306 Haemodynamic and respiratory effects of an abdominal compression binder http://www.medworm.com/index.php?rid=1781850&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00820.x In order to elucidate the circulatory and respiratory effects of a newly developed abdominal compression binder 25 healthy, normal weight subjects were studied. In supine position the central haemodynamics were measured and estimated with a Finapress device. Lower extremity venous haemodynamics were measured in supine position with venous occlusion plethysmography. In an upright-seated position arterial oxygen saturation was measured by a pulseoxymeter for 1 h before spirometry was performed with a turbine flow measurement device. All the tests were performed in a randomized order with or without the abdominal compression binder. The results show that the compression binder significantly increases the venous volume in the lower extremities as showed by a reduction in the venous capacitance... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1781850 Thu, 11 Sep 2008 04:00:00 +0100 1781850 Postexercise reduction in lung diffusion capacity is not attenuated by skin cooling http://www.medworm.com/index.php?rid=1695478&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00821.x Pulmonary diffusion capacity for carbon monoxide (DLCO) is reduced by approximately 10% 1[ndash]6 h after maximal exercise. The mechanisms may be interstitial alveolar oedema and reduced pulmonary capillary blood volume. It was hypothesized that thermal stress following exercise contributes to the reduction in DLCO, and that skin cooling would attenuate the postexercise reduction in DLCO. Cutaneous vascular conductance (CVC), mean surface temperature (MST), rectal temperature and DLCO were measured before and 90 min after maximal incremental cycle exercise. Thereafter, the subjects were exposed to cold air without eliciting shivering one day and another day served as control. The measurements were repeated 120 min after exercise. Twelve healthy subjects (six male) aged 20[ndash]27 years we... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1695478 Tue, 12 Aug 2008 04:00:00 +0100 1695478 Comparison of different views with three-dimensional echocardiography: apical views offer superior visualization compared with parasternal and subcostal views http://www.medworm.com/index.php?rid=1685546&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00823.x Studies seeking to validate real-time three-dimensional echocardiography (3DE) with regard to cardiac function and dimensions have almost exclusively used apical views. However, it has never been examined whether apical views are preferable to parasternal or subcostal views. In the present study, we compared the feasibility of 3DE volumetric measurements of the four heart chambers in three different views. We included 40 patients planned for a routine two-dimensional transthoracic echocardiography examination (2DE). All patients were scanned with both 2DE and 3DE (Sonos 7500; Philips Medical Systems Andover, MA, USA). Parasternal, apical and subcostal views were used for 3DE. Volumes were calculated using manual tracing in 16 planes. 2DE was performed in parasternal longaxis, subcostal and... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1685546 Thu, 07 Aug 2008 04:00:00 +0100 1685546 Blood pressure and heart rate variability analysis of orthostatic challenge in normal human pregnancies http://www.medworm.com/index.php?rid=1685547&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00818.x The aim of the present study was to evaluate pregnancy-related changes in autonomic regulatory functions in healthy subjects. We studied cardiovascular autonomic responses to head-up tilt (HUT) in 28 pregnant women during the third trimester of pregnancy and 3 months after parturition. The maternal ECG and non-invasive beat-to-beat blood pressure were recorded in the horizontal position (left-lateral position) and during HUT in the upright position. Stroke volume was assessed from blood pressure signal by using the arterial pulse contour method. Heart rate variability (HRV) was analysed in frequency domain, and baroreflex sensitivity by the cross-spectral and the sequence methods. In the horizontal position, all frequency components of HRV were lower during pregnancy than 3 months after pa... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1685547 Wed, 06 Aug 2008 04:00:00 +0100 1685547 Prefrontal cortex oxygenation during incremental exercise in chronic fatigue syndrome http://www.medworm.com/index.php?rid=1667850&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00822.x This study examined the effects of maximal incremental exercise on cerebral oxygenation in chronic fatigue syndrome (CFS) subjects. Furthermore, we tested the hypothesis that CFS subjects have a reduced oxygen delivery to the brain during exercise. Six female CFS and eight control (CON) subjects (similar in height, weight, body mass index and physical activity level) performed an incremental cycle ergometer test to exhaustion, while changes in cerebral oxy-haemoglobin (HbO2), deoxy-haemoglobin (HHb), total blood volume (tHb = HbO2 + HHb) and O2 saturation [tissue oxygenation index (TOI), %)] was monitored in the left prefrontal lobe using a near-infrared spectrophotometer. Heart rate (HR) and rating of perceived exertion (RPE) were recorded at each workload throughout the test. Predicted V... Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1667850 Thu, 31 Jul 2008 04:00:00 +0100 1667850 Does a solitary lobar collapse give pressure–lung volume relationship similar to that found in acute respiratory distress syndrome? A porcine experimental study http://www.medworm.com/index.php?rid=1667851&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00819.x Conclusions: PV curves of lungs with solitary lobar collapse are similar to those found in ALI/ARDS. Inspiratory LIP indicated start of recruitment, and expiratory curves did not indicate the pressure at which collapse occurred. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1667851 Wed, 30 Jul 2008 04:00:00 +0100 1667851 Assessment of autonomic symptoms in diabetics: the Swedish version of the Autonomic Symptom Profile http://www.medworm.com/index.php?rid=1614825&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1475-097X.2008.00810.x Conclusion: The Swedish version of the ASP was considered a reliable and valid instrument for the study of AD symptoms in patients with type I diabetes. (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1614825 Sun, 13 Jul 2008 04:00:00 +0100 1614825 Extra cardiac activity detected on myocardial perfusion scintigraphy after intra-arterial injection of 99mTc-MIBI http://www.medworm.com/index.php?rid=1501084&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00811.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR We present an unusual case of extra cardiac activity of 99mTc-MIBI in the left part of thorax and left upper extremity in a patient admitted for myocardial perfusion scintigraphy.Methods: A standard 2-day protocol of 99mTc-MIBI perfusion ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1501084 Fri, 06 Jun 2008 18:13:54 +0100 1501084 Local tissue water assessed by tissue dielectric constant: anatomical site and depth dependence in women prior to breast cancer treatment-related surgery http://www.medworm.com/index.php?rid=1501085&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00814.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryAssessing local tissue water using tissue dielectric constant (TDC) values is useful to evaluate oedema/lymphoedema features and their change. Knowledge of anatomical site and tissue depth dependence of TDC values could extend this method’s ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1501085 Fri, 06 Jun 2008 03:02:39 +0100 1501085 Predicting arterial stiffness with ambulatory blood pressure: an 11-year follow-up http://www.medworm.com/index.php?rid=1501087&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00817.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR This study with 11-year follow-up was launched to evaluate the usefulness of ambulatory intra-... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1501087 Fri, 06 Jun 2008 03:00:24 +0100 1501087 Arterial compliance and endothelium-dependent vasodilation are independently related to coronary risk in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study http://www.medworm.com/index.php?rid=1501086&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00816.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground: Measurements of both arterial compliance and endothelium-dependent vasodilation have previously been related to coronary risk factors, but not in the same study. In the Prospective Investigation of the Vasculature in Uppsala Seniors (... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1501086 Fri, 06 Jun 2008 03:00:24 +0100 1501086 The effect of l-arginine administration on muscle force and power in postmenopausal women http://www.medworm.com/index.php?rid=1474331&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00809.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryPreviously published data (J Bone Miner Res (2005); 20: 471) did not give evidence that the administration of the nitric oxide precursor l-arginine increases bone formation and decreases bone resorption in postmenopausal women. Data of this trial ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1474331 Wed, 28 May 2008 18:15:57 +0100 1474331 Assessment of exercise capacity in women with type 2 diabetes http://www.medworm.com/index.php?rid=1471916&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00808.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryThe primary aim of this study was to compare the maximal oxygen uptake as evaluated from a submaximal exercise test (EVO2peak) to direct measurements of VO2peak during a maximal exercise test as means of monitoring the aerobic endurance capacity in ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1471916 Tue, 27 May 2008 23:24:53 +0100 1471916 Capnovolumetry: a new tool for lung function testing in children with asthma http://www.medworm.com/index.php?rid=1471917&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00815.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryIn capnovolumetry, the expiratory CO2 concentration of exhaled air is plotted against the volume and thereby allows to determine functional dead space volumes. This method might offer additional information in lung function testing in children and ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1471917 Tue, 27 May 2008 18:14:33 +0100 1471917 Recurrences in heart rate dynamics are changed in patients with diabetes mellitus http://www.medworm.com/index.php?rid=1471918&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00813.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryDetection of subclinical autonomic dysfunction in patients with diabetes mellitus (DM) is of vital importance for risk stratification and subsequent management. Heart rate variability (HRV) analysis is a sensitive tool for assessment of ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1471918 Tue, 27 May 2008 18:14:32 +0100 1471918 Obese children show increased intimal wall thickness and decreased pulse wave velocity http://www.medworm.com/index.php?rid=1436055&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00806.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryObjective: Childhood obesity confers an increased risk of vascular changes and adult cardiovascular disease. Using a high-resolution ultrasound technique that enables separation of intimal and medial layers, we examined the intimal thickness (IT) ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1436055 Mon, 12 May 2008 18:16:59 +0100 1436055 Role of retrograde flow in the shear stimulus associated with exercise blood flow http://www.medworm.com/index.php?rid=1436056&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00812.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryTo test the hypothesis that retrograde flow influences the shear stimulus of exercise blood flow, eight healthy men [25·6 ± 3·1 years (SD)] performed 20 min of single-leg knee-extension exercise at two contraction velocities: fast (FR, 1·5 m s−1) ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1436056 Mon, 12 May 2008 07:44:59 +0100 1436056 Association of serotonin transporter promoter regulatory region polymorphism and cerebral activity to visual presentation of food http://www.medworm.com/index.php?rid=1436057&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00804.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryRecent functional magnetic resonance imaging (fMRI) studies have revealed links between genetic polymorphisms and cognitive and behavioural processes. Serotonin is a classical neurotransmitter of central nervous system, and it is connected to the ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1436057 Mon, 12 May 2008 07:44:49 +0100 1436057 Plasma levels of natriuretic peptide type B and A in children with heart disease with different types of cardiac load or systolic dysfunction http://www.medworm.com/index.php?rid=1436058&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00805.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryNatriuretic peptide levels B (BNP) and A (ANP) have been described in children with different diagnose of congenital heart defects (CHD). However, the impact of the type of cardiac load per se on natriuretic peptide levels, irrespective of ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1436058 Mon, 12 May 2008 07:38:50 +0100 1436058 Assessment of autonomic symptoms in diabetics: the Swedish version of the Autonomic Symptom Profile http://www.medworm.com/index.php?rid=1425485&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00810.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryObjectives: Autonomic dysfunction (AD) is a complication of diabetes and may be associated with troubling symptoms and increased mortality. Commonly, AD is detected by objective physiological tests and only recently, a validated self-completed ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1425485 Wed, 07 May 2008 18:14:42 +0100 1425485 Arterial stiffness, endothelial function and microcirculatory reactivity in healthy young males http://www.medworm.com/index.php?rid=1398838&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00807.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryLarge (C1) and small (C2) arterial stiffness has been suggested to parallel endothelial reactivity and has led researchers to suggest parameters of arterial stiffness may be alternative measures to brachial sonographic assessments of flow-mediated ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1398838 Fri, 25 Apr 2008 18:26:44 +0100 1398838 Hyperaemic blood-flow velocities in systole and diastole relate to coronary risk in divergent ways. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study http://www.medworm.com/index.php?rid=1359885&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00797.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 28, Issue 3, Page 189-195, May 2008. SummaryBackground: A recent study suggested blood-flow velocity in diastole during reactive hyperaemia as a major driver of flow-mediated vasodilation (FMD) of the brachial artery, also being related to cardiovascular risk factors. The present study aimed ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1359885 Wed, 09 Apr 2008 04:15:15 +0100 1359885 Impaired nitroglycerin biotransformation in patients with chronic heart failure http://www.medworm.com/index.php?rid=1349141&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00793.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryObjective: Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal. Two pathways leading to biotransformation ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1349141 Thu, 03 Apr 2008 18:24:23 +0100 1349141 Integrin scintimammography using a dedicated breast imaging, solid-state γ-camera and 99mTc-labelled NC100692 http://www.medworm.com/index.php?rid=1349142&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00801.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryObjective: Integrin scintimammography with NC100692 and a dedicated γ-camera, LumaGEM, based on semi-conductor technology, was performed to investigate the detection ability of this combination in breast cancer.Methods: Eight patients with a high ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1349142 Thu, 03 Apr 2008 02:02:30 +0100 1349142 Are baroreflex events detected by invasive and non-invasive techniques coincident? http://www.medworm.com/index.php?rid=1349143&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00803.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryCardiac baroreceptor sensitivity, a prognostic indicator for a range of diseases, such as myocardial infarction and stroke, may be estimated from spontaneous fluctuations of arterial blood pressure (BP) and heart rate using sequence analysis. We ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1349143 Thu, 03 Apr 2008 01:27:27 +0100 1349143 Lipid imaging of human skeletal muscle using TOF-SIMS with bismuth cluster ion as a primary ion source http://www.medworm.com/index.php?rid=1327213&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00796.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryIntramyocellular lipids are of importance in lipid-related diseases. The techniques in this field are limited because of a lack of adequate tools for localization of various lipids. The most usual methods for the localization of lipid distribution ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1327213 Tue, 25 Mar 2008 18:16:48 +0100 1327213 Intrinsic muscle strength and voluntary activation of both lower limbs and functional performance after stroke http://www.medworm.com/index.php?rid=1313646&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00802.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR The objective of this study was to assess the nature of muscle weakness in both legs after stroke compared with able-bodied control individuals and to examine whether there is a relationship between the degree of muscle weakness and coactivation of ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1313646 Wed, 19 Mar 2008 18:23:24 +0100 1313646 Hyperaemic blood-flow velocities in systole and diastole relate to coronary risk in divergent ways http://www.medworm.com/index.php?rid=1313649&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00797.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground: A recent study suggested blood-flow velocity in diastole during reactive hyperaemia as a major driver of flow-mediated vasodilation (FMD) of the brachial artery, also being related to cardiovascular risk factors. The present study aimed ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1313649 Tue, 18 Mar 2008 23:48:17 +0100 1313649 Intra-session repeatability of FET and FEV6 in the general population http://www.medworm.com/index.php?rid=1313647&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00792.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground: The recent American Thoracic Society/European Respiratory Society spirometry guidelines harmonized quality criteria and included assessment of forced expiratory time (FET) in bronchodilation testing when an isolated significant forced ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1313647 Tue, 18 Mar 2008 23:48:10 +0100 1313647 Relationship between muscle oxygenation and electromyography activity during sustained isometric contraction http://www.medworm.com/index.php?rid=1313648&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00798.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryThe purpose of this study was to clarify the relationship between electromyography (EMG) spectrum changes and muscle oxygenation measured by near-infrared time-resolved spectroscopy (TRS). Each subject performed sustained isometric knee extension ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1313648 Tue, 18 Mar 2008 23:47:55 +0100 1313648 Specific nasal symptoms and symptom-provoking factors may predict increased risk of developing COPD http://www.medworm.com/index.php?rid=1293728&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00800.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. AbstractIn a 1992 questionnaire study, we found that certain nasal symptoms and symptom-provoking factors were associated with prevalence of self-reported chronic bronchitis/emphysema (CBE). In this follow-up study, we examined whether any nasal features ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1293728 Tue, 11 Mar 2008 18:14:23 +0100 1293728 Separating the left cardiac ventricle from the atrium in short axis MR images using the equation of the atrioventricular plane http://www.medworm.com/index.php?rid=1279220&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00799.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryShort axis (SA) images obtained from cardiac magnetic resonance imaging are used to advantage in the calculation of important clinical parameters such as the ejection fraction and stroke volume (SV). A prerequisite for these calculations is the ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1279220 Tue, 04 Mar 2008 19:29:14 +0100 1279220 Assessment of coronary blood flow and the reactivity of the microcirculation non-invasively with transthoracic echocardiography http://www.medworm.com/index.php?rid=1264718&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00794.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground: The development in ultrasound technology has allowed the use of non-invasive transthoracic echocardiography (TTE) for the study of coronary artery physiology and pathophysiology. TTE can be used to detect atherosclerotic changes in ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1264718 Thu, 28 Feb 2008 19:33:40 +0100 1264718 Normal limits for left ventricular ejection fraction and volumes determined by gated single photon emission computed tomography – a comparison between two quantification methods http://www.medworm.com/index.php?rid=1257454&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00791.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryTo compare gender-related normal limits for left ventricular (LV) ejection fraction (EF), end-diastolic and end-systolic volumes (EDV and ESV), obtained using two myocardial perfusion-gated single photon emission computed tomography (SPECT) ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1257454 Tue, 26 Feb 2008 19:23:08 +0100 1257454 Enhanced exercise-induced plasma cytokine response and oxidative stress in COPD patients depend on blood oxygenation http://www.medworm.com/index.php?rid=1257455&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00795.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryIn healthy subjects, hypoxemia and exercise represent independent stressors promoting the exercise-induced cytokine response and oxidative stress. We hypothesized that hypoxemia in patients with chronic obstructive pulmonary disease (COPD) may ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1257455 Tue, 26 Feb 2008 02:35:33 +0100 1257455 Variant autonomic regulation during active standing in Swedish and Japanese junior high school children http://www.medworm.com/index.php?rid=1231503&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00790.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryThe present investigation is about cardiovascular responses and relevant autonomic function in Swedish and Japanese pubertal children on active standing using non-invasive continuous beat-to-beat finger arterial pressure (FAP) monitoring and power ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1231503 Thu, 14 Feb 2008 19:19:41 +0100 1231503 Impact of anaesthesia–surgery on D-dimer concentration and end-tidal CO2 and O2 in patients undergoing surgery associated with high risk for pulmonary embolism http://www.medworm.com/index.php?rid=1228699&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00789.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground: The exhaled end-tidal CO2/O2 ratio and the D-dimer concentration are diagnostic markers of pulmonary embolism (PE).Objective: To develop a non-invasive technique to monitor for PE in surgical patients. We examine the change imparted by ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1228699 Wed, 13 Feb 2008 19:10:54 +0100 1228699 Health-related aspects of objectively measured daily physical activity in children http://www.medworm.com/index.php?rid=1199680&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2008.00788.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryIt is well established that physical inactivity in adults is associated with increased mortality and morbidity. Whether daily physical activity level is related to risk factors for cardiovascular disease (CVD) in children has been debated. ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1199680 Mon, 04 Feb 2008 19:09:49 +0100 1199680 Effects of local α2-adrenergic receptor blockade on adipose tissue lipolysis during prolonged systemic adrenaline infusion in normal man http://www.medworm.com/index.php?rid=1199681&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00781.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 28, Issue 2, Page 125-131, March 2008. SummaryDuring prolonged adrenaline infusion, lipolysis peaks within 30 min and thereafter tends to decline, and we hypothesized that the stimulation of local adipose tissue α2-adrenergic receptors accounts for this decline. The lipolytic effect of a ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1199681 Mon, 04 Feb 2008 03:14:57 +0100 1199681 Transoesophageal echocardiography should be considered in patients with ischaemic stroke or transient ischaemic attack http://www.medworm.com/index.php?rid=1151891&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00785.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground and purpose: In this present study, we tried to find out if there is a subgroup of patients that should not undergo transoesophageal echocardiography (TEE) after an ischaemic stroke or transient ischaemic attack (TIA).Methods: A total of ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1151891 Tue, 15 Jan 2008 19:18:07 +0100 1151891 Body fat related to daily physical activity and insulin concentrations in non-diabetic children http://www.medworm.com/index.php?rid=1120299&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00787.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR This study explored the associations between body fat versus daily physical activity and insulin concentrations in non-diabetic young children in a cross-sectional study of 172 children (93 boys and 79 girls) aged 8–11 years. Blood samples were ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1120299 Fri, 28 Dec 2007 20:01:40 +0100 1120299 IGF-1, IGFBP-3, VEGF and MMP-9 levels and their potential relationship with renal functions in patients with compensatory renal growth http://www.medworm.com/index.php?rid=1105604&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00783.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground: Mechanisms of compensatory renal growth (CRG) still remain a mystery. Various growth factors, including growth hormone, insulin-like growth factor-1 (IGF-1) have been implicated in different forms of CRG.Aims: To investigate the serum ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1105604 Wed, 19 Dec 2007 19:07:46 +0100 1105604 Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation http://www.medworm.com/index.php?rid=1105605&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00784.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryBackground: Our objective was to investigate whether serum concentrations of asymmetric dimethylarginine (ADMA) or l-arginine correlate to hyperlipidemia or endothelial function in normal pregnancy compared with the non-pregnant subjects.Methods ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1105605 Wed, 19 Dec 2007 02:28:29 +0100 1105605 Spirometric and anthropometric determinants of forced expiratory time in a general population http://www.medworm.com/index.php?rid=1092607&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00771.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 28, Issue 1, Page 38-42, January 2008. SummaryBackground: Forced expiratory time (FET) has gained new interest in the joint recommendation of the American Thoracic Society (ATS) and the European Respiratory Society (ERS) for the assessment of spirometry. Interpretation of FET is, however, ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1092607 Thu, 13 Dec 2007 01:25:21 +0100 1092607 Objective analysis of whole lung and lobar ventilation/ perfusion relationships in pulmonary embolism http://www.medworm.com/index.php?rid=1092606&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00767.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 28, Issue 1, Page 14-26, January 2008. SummaryPurpose: Lung scintigraphy using single photon emission computed tomography (SPECT) allows accurate regional measurement of the ventilation/perfusion () relationship. Objective analysis has been shown to be useful in the diagnosis of pulmonary ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1092606 Thu, 13 Dec 2007 01:23:27 +0100 1092606 Bone mineral density and single photon emission computed tomography changes after total knee arthroplasty: a 2-year follow-up study http://www.medworm.com/index.php?rid=1089914&cid=s_30481_37_f&fid=30481&url=http%3A%2F%2Fwww.blackwell-synergy.com%2Fdoi%2Fabs%2F10.1111%2Fj.1475-097X.2007.00782.x%3Fai%3Dtb%26mi%3D4mpuw%26af%3DR Clinical Physiology and Functional Imaging, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryDual X-ray absorptionmetry (DXA) provides a highly reproducible method for quantitative analysis and monitoring periprosthetic bone mineral density (BMD) after total knee arthroplasty (TKA). Single photon emission computed tomography (SPECT) with ... (Source: Clinical Physiology and Functional Imaging) Clinical Physiology and Functional Imaging journals http://www.medworm.com/rss/comments.php?id=1089914 Wed, 12 Dec 2007 19:07:02 +0100 1089914