MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical and Experimental Allergy' source. Wed, 08 Feb 2012 06:42:47 +0100 http://www.medworm.com/index.php?rid=5666419&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03976.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5666419 Mon, 06 Feb 2012 05:00:00 +0100 5666419 http://www.medworm.com/index.php?rid=5666418&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03977.x Conclusions & Clinical RelevanceWe conclude that in patients with adult onset asthma, male gender and absence of atopy are associated with persistent airflow limitation. This might suggest that amongst patients with adult onset asthma, non‐atopic male patients are at increased risk of accelerated decline in lung function.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5666418 Mon, 06 Feb 2012 05:00:00 +0100 5666418 http://www.medworm.com/index.php?rid=5659204&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03973.x Conclusions and Clinical Relevance:Our results suggest that inflammation is present in the central and peripheral airways and that it is associated with the severity of EIB. Clinicaltrials.govNCT00952835© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5659204 Fri, 03 Feb 2012 05:00:00 +0100 5659204 http://www.medworm.com/index.php?rid=5646580&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03970.x Conclusions and Clinical RelevanceThis study shows distinct patterns for immediate reactions due to occupational agents. These results can provide useful guidelines for performing specific inhalation challenges and improve the safety of the procedure.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5646580 Tue, 31 Jan 2012 05:00:00 +0100 5646580 http://www.medworm.com/index.php?rid=5646579&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03971.x Conclusions and Clinical RelevanceThe first DBPC SCIT‐DRF with a mixture of recombinant Phleum allergens (Phl p 1, 2, 5a, 5b, 6) in patients with rhinoconjunctivitis plus/minus asthma showed no major side effects in very high doses up to 120 μg.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5646579 Tue, 31 Jan 2012 05:00:00 +0100 5646579 http://www.medworm.com/index.php?rid=5646582&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03962.x AbstractAsthma is common, and some individuals are severely affected by it. Learned institutions have sought to provide a definition of “severe asthma” to facilitate research and clinical care. This is a challenging undertaking given the difficulty in defining asthma and the lack of supportive evidence for a distinct severe asthma phenotype. In this review we discuss the rationale for a definition of severe asthma and the relative merits of the sequential attempts that have been made to produce such a definition. The difficulty in disentangling control and severity is highlighted, as is the heterogeneity of phenotype in severe asthma, and potential for misclassification. We conclude that the search for a singular definition of severe asthma is problematic, though likely to continue. We... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5646582 Mon, 30 Jan 2012 05:00:00 +0100 5646582 http://www.medworm.com/index.php?rid=5646581&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03953.x AbstractImmunoglobulin E (IgE) mediated immune responses seem to be directed against parasites and neoplasms but are best known for their involvement in allergies. The IgE network is tightly controlled at different levels as outlined in this review. Genetic determinants were suspected to influence IgE regulation and IgE levels considerably for many years. Linkage and candidate gene studies suggested a number of loci and genes to correlate with total serum IgE levels and recently genome‐wide association studies (GWAS) provided the power to identify genetic determinants for total serum IgE levels: 1q23 (FCER1A), 5q31 (RAD50,IL13,IL4), 12q13 (STAT6), 6p21.3 (HLA‐DRB1) and 16p12 (IL4R,IL21R). In this review we analyze the potential role of these GWAS hits in the IgE network and suggest mec... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5646581 Mon, 30 Jan 2012 05:00:00 +0100 5646581 http://www.medworm.com/index.php?rid=5637802&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03963.x AbstractThe role of small airway abnormalities in asthma pathogenesis has been extensively studied and debated for several decades. However, whether small airway abnormalities play a relevant role in specific phenotypes of asthmatic patients and contribute to clinical presentation, is largely unknown. In the present review we evaluated available data on the role of small airways in severe asthma, with a further focus on asthma in smokers and asthma in the elderly. These phenotypes are characterised by a poor response to treatment and they can represent a model of greater small airway impairment. In severe asthmatics, small airway involvement has been shown through evidence of both distal inflammation and of increased air trapping. The few available data in asthmatics who smoke and elderly ... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5637802 Fri, 27 Jan 2012 05:00:00 +0100 5637802 http://www.medworm.com/index.php?rid=5637801&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03964.x AbstractThe skin represents a physical barrier, which is capable to protect the body from damaging invaders. Moreover, the skin operates as an active immunological organ, harbouring a complex network of dendritic cells (DCs), which serve as a bridge between innate and adaptive immunity. Equipped with specific pattern recognition receptors (PRRs), DCs are able to capture, process and present antigens to naïve T cells in the skin draining lymph nodes, thereby inducing adaptive antigen‐specific immunity. However, the outcome of the immune response is shaped by numerous factors including the DC subtype, maturation state of DCs, composition of PRRs expressed by DCs, type of pathogen as well as factors in the microenvironment. Thus, cutaneous DC subtypes are known to contribute to both, perip... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5637801 Fri, 27 Jan 2012 05:00:00 +0100 5637801 http://www.medworm.com/index.php?rid=5637800&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03965.x ConclusionsA variety of new treatment options are being investigated to help improve overall asthma control in patients with severe refractory asthma. These include medications to optimize lung function; bronchial thermoplasty to reduce airway smooth muscle in central airways; and those which target specific inflammatory cells or receptors of inflammatory mediators.Clinical RelevancePatients with severe refractory asthma have the greatest unmet treatment needs to improve asthma control and reduce exacerbation risk. New treatment approaches have been identified which will benefit subsets of these patients. Phenotyping patients is necessary to select those likely to benefit.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5637800 Fri, 27 Jan 2012 05:00:00 +0100 5637800 http://www.medworm.com/index.php?rid=5637799&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03967.x AbstractChronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide with smoking being the most important risk factor of the disease. However, lung function and COPD are known to also have a genetic component and a deeper knowledge of the genetic architecture of the disease could lead to further understanding of predisposition to COPD and also to development of new therapeutic interventions. Genetic linkage studies and candidate gene association studies have not provided evidence to convincingly identify the genes underlying lung function or COPD. However, recent large genome‐wide association studies (GWAS) including tens of thousands of individuals have identified 26 variants at different loci in the human genome that show robust associatio... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5637799 Fri, 27 Jan 2012 05:00:00 +0100 5637799 http://www.medworm.com/index.php?rid=5637798&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03966.x Conclusion and Clinical RelevanceThe glycosylated MRJP8 and MRJP9 of honeybee venom have IgE‐sensitizing potential in honeybee venom allergic patients beyond CCD reactivity and have to be considered as allergens, which might be potentially important for a fraction of venom allergic patients. They are valuable tools to elucidate individual component‐resolved reactivity profiles of venom allergic patients and to provide insights into the role of particular venom components. Due to their allergenic properties MRJP8 and MRJP9 were designated as isoallergens Api m 11.0101 and Api m 11.0201, respectively.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5637798 Fri, 27 Jan 2012 05:00:00 +0100 5637798 http://www.medworm.com/index.php?rid=5646583&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03925.x This article reviews the current evidence for the role of breastfeeding in the prevention of allergic disease. We found considerable methodological limitations inherent in most studies evaluating the effect of breastfeeding in allergic disease. Nevertheless, since randomized control trials in breast feeding research would be considered unethical, the evidence remains limited to poorer quality observational studies where participation and recall bias can severely affect the objectivity of the data collected. Furthermore, reporting of type of breastfeeding (exclusive, full or partial) may be biased by a participant's inherent belief system of what they think they should be doing. Current evidence is inconclusive regarding the effect of breastfeeding on the development of eczema, with the mos... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5646583 Thu, 26 Jan 2012 05:00:00 +0100 5646583 http://www.medworm.com/index.php?rid=5627769&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03925.x This article reviews the current evidence for the role of breastfeeding in the prevention of allergic disease. We found considerable methodological limitations inherent in most studies evaluating the effect of breastfeeding in allergic disease. Nevertheless, since randomized control trials in breast feeding research would be considered unethical, the evidence remains limited to poorer quality observational studies where participation and recall bias can severely affect the objectivity of the data collected. Furthermore, reporting of type of breastfeeding (exclusive, full or partial) may be biased by a participant's inherent belief system of what they think they should be doing. Current evidence is inconclusive regarding the effect of breastfeeding on the development of eczema, with the mos... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5627769 Thu, 26 Jan 2012 05:00:00 +0100 5627769 http://www.medworm.com/index.php?rid=5607636&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03928.x ConclusionDespite fewer severe exacerbations with SMART therapy as compared to ICS monotherapy or lower dose ICS/LABA therapy, the strategy produces poor day‐to‐day control of symptoms and is associated with increasing inflammation.Clinical RelevanceThe symptom‐reactive strategy described as SMART therapy is associated with poor symptom control of asthma. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5607636 Wed, 18 Jan 2012 05:00:00 +0100 5607636 http://www.medworm.com/index.php?rid=5607635&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03929.x AbstractAsthma, and severe asthma, in particular, is increasingly recognized as a heterogeneous disease. While traditional views of asthma have centered around a childhood onset disease with an allergic component, several large scale network studies are now confirming that severe asthma can present in multiple different ways, only 30–50% of which meet traditional childhood onset allergic criteria. To understand the different groups better, initial studies have attempted to define phenotypes of severe asthma. A phenotype is defined as the integration of different characteristics that are the product of the interaction of the patient's genes with the environment. Both clinical and statistical approaches have identified at least 3–5 phenotypes of severe asthma. However, these phenotypes, ... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5607635 Wed, 18 Jan 2012 05:00:00 +0100 5607635 http://www.medworm.com/index.php?rid=5607634&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03930.x Conclusion and Clinical RelevanceThis study revealed a higher rate of anaphylaxis than that in previous studies, although this incidence rate is probably lower than the real incidence rate. Studies exploring potential methodological, genetic and environmental factors accounting for these higher rates of anaphylaxis are required. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5607634 Wed, 18 Jan 2012 05:00:00 +0100 5607634 http://www.medworm.com/index.php?rid=5607633&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03935.x Conclusions and clinical relevanceSleep quality is altered in AR patients. Sleep quality was worse in moderate‐severe, and particularly in severe AR. Nasal obstruction and RQLQ deterioration are associated with a poorer sleep quality. Sleep impairment is common in allergic rhinitis, particularly in more severe forms. Nasal obstruction and concomitant asthma should be considered as contributing factors.Capsule summaryThis is a large epidemiological survey of patients with allergic rhinitis showing a strong relationship between disease severity, as assessed by a consensus classification, and sleep impairment, as measured by a validated sleep quality tool. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5607633 Wed, 18 Jan 2012 05:00:00 +0100 5607633 http://www.medworm.com/index.php?rid=5607632&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03959.x AbstractSevere asthmatics often exhibit poor control despite high doses of inhaled corticosteroids with or without systemic corticosteroids and suffer from persistent symptoms and/or recurrent exacerbations. 5 to 10% of the asthmatic population falls within this category. Patients with severe asthma are a heterogeneous group and should be investigated to confirm the diagnosis, identify comorbidities,exclude alternative diagnoses, together with an evaluation of treatment adherence and side‐effects from medications. Optimisation of asthma medications and monitoring the control and pattern of asthma usually takes place over a period of 6 months. In patients with confirmed severe refractory asthma, further evaluation is needed in terms of detailed lung function, of airway and lung structure ... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5607632 Tue, 17 Jan 2012 05:00:00 +0100 5607632 http://www.medworm.com/index.php?rid=5580468&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03924.x Conclusions and Clinical RelevanceOur results do not support a strong association between selenium status and the high incidence of asthma in New Zealand. However, there was a modest association between lower PlSe and WBGPx activity and higher incidence of persistent wheeze. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5580468 Thu, 12 Jan 2012 05:00:00 +0100 5580468 http://www.medworm.com/index.php?rid=5580467&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03927.x SummaryFood allergy has become an emerging health problem in Western societies. Although food allergy is characterized by a relatively low mortality and an almost continual absence of physical symptoms, food allergic patients are continually confronted with the possibility of potentially severe reactions and the necessity of dietary vigilance. Health‐related quality of life (HRQL) may be the only meaningful outcome measure available for food allergy measuring this continuous burden. HRQL may be measured with generic or disease‐specific instruments. Generic instruments may be relatively unresponsive to differences or changes in health status, whereas disease‐specific instruments are generally more sensitive for relatively subtle problems related to a particular illness. Recently, a nu... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5580467 Thu, 12 Jan 2012 05:00:00 +0100 5580467 http://www.medworm.com/index.php?rid=5580466&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03931.x Conclusions and Clinical RelevanceThese results suggest that HDAC inhibition is associated with myofibroblast differentiation and extracelluar matrix accumulation in nasal polyposis. TSA may be useful as an inhibitor of nasal polyp growth, and thus has potential to be used as a novel treatment option for nasal polyposis. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5580466 Thu, 12 Jan 2012 05:00:00 +0100 5580466 http://www.medworm.com/index.php?rid=5666417&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03975.x Conclusions and Clinical RelevanceThis study showed that the protective effect of HN001 against eczema, when given for the first 2 years of life only, extended to at least 4 years of age. This, together with our findings for a protective effect against rhinoconjunctivitis, suggests that this probiotic might be an appropriate preventative intervention for high risk infants.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5666417 Sun, 01 Jan 2012 05:00:00 +0100 5666417 http://www.medworm.com/index.php?rid=5659203&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03974.x AbstractConventional rodent models of respiratory allergy that employ intraperitoneal sensitization to aeroallergen plus adjuvant, have offered greatly to our current knowledge of the pathophysiology of allergic airway diseases. Notwithstanding this significant contribution, non‐adjuvant aided sensitization via respiratory presentation of the allergen, is more naturally relevant and more closely mimics the human exposure. Nevertheless, in the experimental setting, primary respiratory exposure to inert antigen is likely to lead to inhalation tolerance. Inasmuch as divergent and discrepant results are often reported in experimental models employing this method of sensitization, we set out to review the relative literature and identify and discuss factors that are liable to interfere in suc... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5659203 Sun, 01 Jan 2012 05:00:00 +0100 5659203 http://www.medworm.com/index.php?rid=5646578&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03972.x Conclusions and Clinical RelevanceThe effect of adiposity on asthma was mainly seen in non‐atopics and did not appear to depend on the distribution of adiposity as reflected by the adiposity measures used in the present study. Increasing adiposity was associated with lower lung function independent of atopic status.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5646578 Sun, 01 Jan 2012 05:00:00 +0100 5646578 http://www.medworm.com/index.php?rid=5637797&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03969.x Conclusions and Clinical RelevancePromotion of predominant breastfeeding for 4 to 6 months could reduce the burden of allergic manifestations and infections in infancy. Beneficial effects of breastfeeding on gastroenteritis were explained in part by exposure to higher doses of n‐3 and AA received from colostrum. No significant effects from fatty acid dose were found on risk of allergic manifestations or LRTIs.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5637797 Sun, 01 Jan 2012 05:00:00 +0100 5637797 http://www.medworm.com/index.php?rid=5607631&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03961.x Conclusion and Clinical RelevanceThe characterized recombinant wheat allergens may be useful for the development of serological tests which allow the discrimination of different clinical manifestations of wheat allergy.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5607631 Sun, 01 Jan 2012 05:00:00 +0100 5607631 http://www.medworm.com/index.php?rid=5596654&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03957.x AbstractUrticaria, and especially chronic spontaneous urticaria, is a difficult condition to treat. Consequently, clinicians need to use the best H1‐antihistamines currently available and the pharmaceutical industry need to keep developing H1‐antihistamines that are more effective than the ones we have today. To do this we need to be able to compare the clinical efficacy of both established and new drugs. Obviously, the ideal way to do this is to use head to head studies in CSU. However, such studies are extremely expensive and, in the case of novel molecules, have ethical and logistical problems. Consequently, we need to have predictive models. While determination of Ki, an indicator of the in vitro potency of an H1‐antihistamine, may help in the initial selection of candidate molec... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5596654 Sun, 01 Jan 2012 05:00:00 +0100 5596654 http://www.medworm.com/index.php?rid=5580465&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03956.x Conclusions and Clinical Relevance:Our studies demonstrate that GITRL expression is augmented by Th2 cytokines and TNFα in keratinocytes. Increased GITRL expession in acute AD skin lesions is shown. This data suggests a link between cytokine regulated keratinocyte GITRL expression and its role in inflammatory responses in AD.© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5580465 Sun, 01 Jan 2012 05:00:00 +0100 5580465 http://www.medworm.com/index.php?rid=5559144&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2012.03944.x SummaryThe classification of asthma to identify forms which have different contributing causes is useful for all cases in which the disease requires regular treatment, but it is essential for the management of severe asthma. Many forms of the disease can occur, and complex mixtures are not uncommon; here we artificially separated the cases into four groups: i) inhalant allergy, ii) fungal sensitization with or without colonization (including ABPA); iii) severe sinusitis with or without aspirin‐exacerbated respiratory disease (AERD), and iv) non‐inflammatory cases, including those associated with severe obesity and vocal cord dysfunction (VCD). The reason for focusing on these groups is because they illustrate how much the specific management depends upon correct classification. Inhalan... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5559144 Sun, 01 Jan 2012 05:00:00 +0100 5559144 http://www.medworm.com/index.php?rid=5551761&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03951.x Conclusions and Clinical relevanceThe spirometric values decreased significantly in proportion to the increase of BMI and age in patients with asthma, especially among young adults. There was not a negative correlation between BMI and FEV1 in the group ≥ 60 years of age, suggesting that perhaps the time of disease is a major factor in the loss of lung function than weight gain in the elderly.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551761 Fri, 30 Dec 2011 23:43:38 +0100 5551761 http://www.medworm.com/index.php?rid=5551768&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03946.x Conclusions:With disparities emerging as early as age 2 years, investigations into sources of the disparities should include the prenatal period and early life.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551768 Wed, 28 Dec 2011 05:00:00 +0100 5551768 http://www.medworm.com/index.php?rid=5551767&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03947.x Conclusion:Elevated exhaled nitric oxide levels predicted incident and persistent rhinitis in this population‐based study of adolescents. Moreover, these findings were consistent after excluding subjects with allergic symptoms. Thus, it appears that elevation of exhaled NO precedes airway symptoms and predicts development of rhinitis in subjects without allergic symptoms or family history of allergic disease.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551767 Wed, 28 Dec 2011 05:00:00 +0100 5551767 http://www.medworm.com/index.php?rid=5551766&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03945.x Conclusions and Clinical Relevance:These results suggested that past smoking history, blood eosinophilia, and chronic rhinosinusitis are involved in the persistent airway inflammation detected by FENO. Although their relative contributions on FENO values should be further quantified, clarification of the features of the subjects with high FENO might provide clues for adjustment of the treatment approach in asthma.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551766 Wed, 28 Dec 2011 05:00:00 +0100 5551766 http://www.medworm.com/index.php?rid=5551765&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03949.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551765 Wed, 28 Dec 2011 05:00:00 +0100 5551765 http://www.medworm.com/index.php?rid=5551764&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03948.x Conclusions & Clinical Relevance:A potentially large benefit of oral immunotherapy in patients with cow's milk allergy may be counterbalanced by frequent and sometimes serious adverse effects. Additional, larger RCTs measuring all patient‐important outcomes are still needed.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551764 Wed, 28 Dec 2011 05:00:00 +0100 5551764 http://www.medworm.com/index.php?rid=5551763&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03954.x Conclusions & Clinical RelevanceReactions to peanut and tree nuts are as common as reactions to milk and egg in early life. Concomitant exposure to airborne allergens seems to increase the risk of anaphylaxis to foods. Among children with anaphylaxis, wheeze is prevalent even in children without asthma diagnosis.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551763 Wed, 28 Dec 2011 05:00:00 +0100 5551763 http://www.medworm.com/index.php?rid=5551762&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03950.x Conclusions & Clinical RelevanceIn our cohort, higher maternal total aerobes and enterococci were related to increased risk of infant wheeze. Maternal intestinal flora may be an important environmental exposure in early immune system development.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5551762 Wed, 28 Dec 2011 05:00:00 +0100 5551762 http://www.medworm.com/index.php?rid=5543799&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03906.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543799 Tue, 27 Dec 2011 23:45:09 +0100 5543799 http://www.medworm.com/index.php?rid=5543798&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03907.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543798 Tue, 27 Dec 2011 23:45:08 +0100 5543798 http://www.medworm.com/index.php?rid=5543797&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03913.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543797 Tue, 27 Dec 2011 23:45:06 +0100 5543797 http://www.medworm.com/index.php?rid=5543796&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03909.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543796 Tue, 27 Dec 2011 23:45:05 +0100 5543796 http://www.medworm.com/index.php?rid=5543795&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03902.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543795 Tue, 27 Dec 2011 23:44:38 +0100 5543795 http://www.medworm.com/index.php?rid=5543794&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03877.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543794 Tue, 27 Dec 2011 23:44:36 +0100 5543794 http://www.medworm.com/index.php?rid=5543793&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03910.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543793 Tue, 27 Dec 2011 23:44:35 +0100 5543793 http://www.medworm.com/index.php?rid=5543792&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03922.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5543792 Tue, 27 Dec 2011 23:44:33 +0100 5543792 http://www.medworm.com/index.php?rid=5537228&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03921.x Conclusions and Clinical RelevanceLPS‐induced neutrophil recruitment was reduced by inhibition of CXCR2. This outcome mimicked the response previously seen in a lower airway LPS model. Hence, the nasal model offers a convenient and well‐tolerated alternative for pharmacological evaluation of anti‐inflammatory drugs affecting neutrophilic migration and activity. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5537228 Thu, 22 Dec 2011 05:00:00 +0100 5537228 http://www.medworm.com/index.php?rid=5537227&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03917.x SummarySevere asthma is a heterogeneous disease with substantial unmet clinical need. Airway damage and remodelling is a consequence of complex host–environment interactions and is considered to be the cardinal feature leading onto the development and persistence of airflow obstruction. In this review, we shall bring together recent insights into the causes of airway damage and remodelling that propose key roles for pathogens and mechanical damage in addition to allergens, underlying genetic susceptibility, inflammatory and structural cell interactions, and impaired resolution of damage. We shall consider the consequences of airway remodelling in terms of airway geometry, mechanics and clinical expression of disease. Understanding the causes and consequences of airway damage and remodell... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5537227 Thu, 22 Dec 2011 05:00:00 +0100 5537227 http://www.medworm.com/index.php?rid=5537226&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03923.x AbstractIn Western countries, the incidence of atopy and allergic diseases is high and further rising. While genetic factors certainly play a role, epigenetic or even nutritional factors might also be important in the pathogenesis of allergies. Vitamin D – the ‘sunshine hormone’ – exerts profound effects on both adaptive and innate immune functions involved in the development and course of allergic diseases. As also the incidence of vitamin D insufficiency is surprisingly high in the general population, clinical and experimental studies have started to investigate if correcting vitamin D levels [measured as serum 25 hydroxy vitamin D ‐25(OH)D] is beneficial or even protective in patients with allergies or children at risk. This review highlights current data on the effects of vit... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5537226 Thu, 22 Dec 2011 05:00:00 +0100 5537226 http://www.medworm.com/index.php?rid=5537225&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03920.x Conclusion and Clinical RelevancePatients with positive shrimp challenges present in general more intense and diverse epitope recognition to all four shrimp allergens. IgE antibodies to these shrimp epitopes could be used as biomarkers for prediction of clinical reactivity in subjects with sensitization to shrimp. Patients with positive shrimp challenges show more intense sensitization and more diverse epitope recognition. Several IgE‐binding shrimp epitopes could be used as biomarkers for predicting clinical reactivity in subjects with sensitization to shrimp. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5537225 Thu, 22 Dec 2011 05:00:00 +0100 5537225 http://www.medworm.com/index.php?rid=5523698&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03912.x Conclusions and Clinical RelevanceAdrenaline is used by only a minority of patients experiencing anaphylaxis in the community. Thirteen of the 41 patients with anaphylaxis who used their autoinjector needed another dose of adrenaline. Further research is needed to consider how to best encourage the usage of adrenaline when clinically indicated in anaphylaxis. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5523698 Mon, 19 Dec 2011 05:00:00 +0100 5523698 http://www.medworm.com/index.php?rid=5504099&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03911.x AbstractHelminth (worm) therapy has already been used in clinical trials associated with allergy. These were generally small scale, safety orientated trials of short duration, justified by epidemiological and experimental data indicating potentially beneficial immune modulation by some parasites. However, parasites by definition are disadvantageous to their hosts, and helminth infection in particular almost invariably induces an allergic phenotype, rendering this somewhat paradoxical therapeutic approach for allergy open to scrutiny. Is parasitic worm therapy for allergy incongruous medicine, or avant‐garde medicine? In the present article, we assess the strength of evidence supporting the use of helminth therapy for allergy and critically appraise the trials already completed. Then, sho... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5504099 Wed, 14 Dec 2011 05:00:00 +0100 5504099 http://www.medworm.com/index.php?rid=5504098&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03915.x Conclusion and Clinical RelevanceThe Gal d 1 IgE reactivity appears to be a very good predictor of HE clinical allergy. Gal d 1 positive children have a high frequency of HE allergy, whereas Gal d 1 negative children have a high frequency of tolerance to boiled egg. Multiple specific IgE detection by means of ISAC improves the diagnostic approach in HE allergic children, disclosing other food and inhalant allergic sensitizations, anyhow requiring a comprehensive clinical evaluation. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5504098 Wed, 14 Dec 2011 05:00:00 +0100 5504098 http://www.medworm.com/index.php?rid=5504097&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03918.x Conclusion and clinical relevanceThese findings suggest that NGF derived from bronchial and alveolar epithelium plays an important role in AHR after chronic exposure to mite antigen. NGF inhibition could potentially manage bronchial asthma, including AHR. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5504097 Wed, 14 Dec 2011 05:00:00 +0100 5504097 http://www.medworm.com/index.php?rid=5504096&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03919.x AbstractThymic stromal lymphopoietin (TSLP) is a key pro‐allergic cytokine that has recently been linked to chronic airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). High levels of TSLP were detected in bronchial mucosa of asthma and COPD patients suggesting TSLP's biological role beyond a signature ‘Th2‐favoring’ or ‘pro‐allergic cytokine’. Besides inflammatory cells, airway structural cells produce and are targets of TSLP suggesting a potential autocrine loop that may have a profound effect on local inflammatory response and airway remodelling. This review sums up diverse mechanisms that mediate TSLP/TSLP receptor‐signalling network in chronic airway diseases. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5504096 Wed, 14 Dec 2011 05:00:00 +0100 5504096 http://www.medworm.com/index.php?rid=5504095&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03941.x Conclusion and Clinical Relevance:Our findings suggest modest effects by probiotics on T cell maturation following 9 months of probiotic intake. Future studies should address if specific probiotics may drive immune development with possible preventive effects on the development of allergic disease.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5504095 Tue, 13 Dec 2011 05:00:00 +0100 5504095 http://www.medworm.com/index.php?rid=5504094&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03940.x Conclusions & Clinical Relevance:Low serum high density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of pediatric asthma.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5504094 Tue, 13 Dec 2011 05:00:00 +0100 5504094 http://www.medworm.com/index.php?rid=5494309&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03937.x Conclusion and Clinical Relevance:Proteolytic activity of Per a 10 modulates DCs towards type 2 by CD86 up‐regulation, high IL‐6 and reduced IL‐12 secretions. Proteolytically inactive Per a 10 can be further explored for immunotherapy. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5494309 Mon, 12 Dec 2011 05:00:00 +0100 5494309 http://www.medworm.com/index.php?rid=5494308&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03936.x AbstractSevere asthma is considered a heterogeneous disease in which a variety of clinical, physiological and inflammatory markers determine disease severity. Pivotal studies in the last 5 years have led to substantial progress in many areas, ranging from a more accurate definition of truly severe, refractory asthma, to classification of the disease into distinct clinical phenotypes, and introduction of new therapies. This review focuses on three common clinical phenotypes of severe asthma in adults (early onset severe allergic asthma, late onset non‐atopic eosinophilic asthma, late onset non‐eosinophilic asthma with obesity), and provides an overview of recent developments regarding treatment options that are best suited for each of these phenotypes. (Source: Clinical and Experimental... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5494308 Mon, 12 Dec 2011 05:00:00 +0100 5494308 http://www.medworm.com/index.php?rid=5504093&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03943.x Conclusion & Clinical Relevance:CSS is clearly distinguished from bronchial asthma, and HES by a marked increase in 12‐HETE concentration in both EBC and BALF. This points to a possible new pathogenic mechanism in CSS and may help in future in establishing the diagnosis of CSS.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5504093 Thu, 01 Dec 2011 05:00:00 +0100 5504093 http://www.medworm.com/index.php?rid=5494307&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03938.x Conclusion:Our results demonstrated that a mutant hybrid expressing genetically engineered forms of the major P.judaica allergens displayed reduced allergenicity and retained T cell reactivity for the induction of protective antibodies in vaccination approaches for the treatment of Parietaria pollinosis.© 2011 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5494307 Thu, 01 Dec 2011 05:00:00 +0100 5494307 http://www.medworm.com/index.php?rid=5440043&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03896.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440043 Thu, 24 Nov 2011 23:45:24 +0100 5440043 http://www.medworm.com/index.php?rid=5440042&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03897.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440042 Thu, 24 Nov 2011 23:45:23 +0100 5440042 http://www.medworm.com/index.php?rid=5440041&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03876.x Cite this as: M. A. Rose, R. Schubert, J. Schulze and S. Zielen, Clinical & Experimental Allergy, 2011 (41) 1819;–1821. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440041 Thu, 24 Nov 2011 23:45:21 +0100 5440041 http://www.medworm.com/index.php?rid=5440040&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03872.x Cite this as: A. Martorell and B. de la Hoz, on behalf of the authors, Clinical & Experimental Allergy, 2011 (41) 1817–1818 (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440040 Thu, 24 Nov 2011 23:45:20 +0100 5440040 http://www.medworm.com/index.php?rid=5440039&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03871.x Cite this as: L. Hulshof, A. A. Schoemaker, N. C. M. Petrus, W. M. C. van Aalderen and A. B. Sprikkelman, Clinical & Experimental Allergy, 2011 (41) 1815–1816. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440039 Thu, 24 Nov 2011 23:45:18 +0100 5440039 http://www.medworm.com/index.php?rid=5440038&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03892.x SummaryIn 2010 over 200 articles were published in Clinical and Experimental Allergy including editorials, reviews, opinion articles, letters, book reviews and of course at the heart of the journal, papers containing original data which have moved the field of allergy forward on a number of fronts. For the third year running the editors felt it would be of value to summarize the key messages contained in these papers as a snapshot of where the cutting edge of research into allergic disease is leading. We have broadly followed the sections of the journal, although this year the mechanistic articles are grouped together and the studies involving experimental models of disease are discussed throughout the paper. In the field of asthma and rhinitis phenotypes and biomarkers continue to a major... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440038 Thu, 24 Nov 2011 23:44:58 +0100 5440038 http://www.medworm.com/index.php?rid=5440037&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03893.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440037 Thu, 24 Nov 2011 23:44:53 +0100 5440037 http://www.medworm.com/index.php?rid=5440036&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03884.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440036 Thu, 24 Nov 2011 23:44:51 +0100 5440036 http://www.medworm.com/index.php?rid=5440035&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2009.03895.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5440035 Thu, 24 Nov 2011 23:44:50 +0100 5440035 http://www.medworm.com/index.php?rid=5406335&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03900.x Conclusion and clinical relevanceDau c 1 isoforms display distinct IgE epitope heterogeneity. Dau c 1.03 appears to contribute to the allergenicity of carrots and the manifestation of carrot allergy. The epitope diversity of different Dau c 1 isoforms should be considered for component‐resolved diagnosis and gene silencing of carrot allergens. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5406335 Tue, 15 Nov 2011 05:00:00 +0100 5406335 http://www.medworm.com/index.php?rid=5406337&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03898.x ConclusionsIn early stage chronic sinus disease, TGF‐beta protein is expressed in significantly higher concentrations within the paranasal sinuses when compared to turbinates, whereas pro‐inflammatory, neutrophilic and Th1 markers did not show any difference. These findings suggest that TGF‐beta plays a central role in the initiation of CRSsNP, and represents a major target for further research and future intervention. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5406337 Mon, 14 Nov 2011 05:00:00 +0100 5406337 http://www.medworm.com/index.php?rid=5406336&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03899.x SummaryAtopic dermatis (AD) is a very common inflammatory skin disease in childhood. Various doctors such as paediatricians, general practitioners, allergologists and dermatologists are regularly consulted by these children and their parents, but there is no clear consensus on the diagnostic work‐up that should be performed when evaluating a child with eczema. A careful history, clinical examination and adequate documentation of disease severity are essential in all children with eczema, irrespective of their disease severity. AD is a clinical diagnosis; diagnostic criteria, such as the UK diagnostic criteria, can be helpful for an accurate definition of the disease. A careful history, including alarm symptoms, respiratory symptoms and the impact of the disease on psychosocial functionin... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5406336 Mon, 14 Nov 2011 05:00:00 +0100 5406336 http://www.medworm.com/index.php?rid=5399768&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03903.x SummaryMost of the important mammal‐derived respiratory allergens, as well as a milk allergen and a few insect allergens, belong to the lipocalin protein family. As mammalian lipocalin allergens are found in dander, saliva and urine, they disperse effectively and are widely present in the indoor environments. Initially, lipocalins were characterized as transport proteins for small, principally hydrophobic molecules, but now they are known to be involved in many other biological functions. Although the amino acid identity between lipocalins is generally at the level of 20–30%, it can be considerably higher. Lipocalin allergens do not exhibit any known physicochemical, functional or structural property that would account for their allergenicity, that is, the capacity to induce T‐helper... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5399768 Wed, 09 Nov 2011 05:00:00 +0100 5399768 http://www.medworm.com/index.php?rid=5399767&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03894.x Conclusion and Clinical RelevanceOur results show that ASMC are a potent source of CCL15 in the airways and may directly participate in the recruitment of inflammatory cells to asthmatic airways. Targeting the production of CCL15 by ASMC might reduce the inflammatory response within the airways of asthmatic patients. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5399767 Wed, 09 Nov 2011 05:00:00 +0100 5399767 http://www.medworm.com/index.php?rid=5399769&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03891.x Conclusions and Clinical RelevanceOur findings suggest that the greater diversity in prevalence of AR or AR/C in populations in these regions is in contrast to the lower diversity of AR or AR/C in the ‘western populations (USA and Europe), which tend to be more uniform. This review provides a comprehensive database of the important allergens and triggers which are likely to influence the prevalence of allergic rhinitis in these diverse regions, where the prevalence of allergic rhinitis is increasing and its adverse impact on the quality of life of affected individuals is increasingly recognised. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5399769 Thu, 03 Nov 2011 04:00:00 +0100 5399769 http://www.medworm.com/index.php?rid=5421198&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03904.x Conclusions and clinical relevanceEarly innate immunity responses in the gut are associated with the emergence of sensitization and atopic dermatitis later in childhood. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5421198 Tue, 01 Nov 2011 04:00:00 +0100 5421198 http://www.medworm.com/index.php?rid=5406334&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03905.x ConclusionsMothers experienced increased anxiety on the day of food challenge, unlike the children, perhaps reflecting the differences in their perceived risks. Food challenges are associated with improved food‐related QoL in the following months even in those with a positive challenge. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5406334 Tue, 01 Nov 2011 04:00:00 +0100 5406334 http://www.medworm.com/index.php?rid=5399766&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03882.x Conclusions and clinical relevanceThese findings suggest that the relationship between immunomodulatory T cell subsets, allergic sensitization and eczema is developmentally regulated. In the first year of life, CD4+CD25+IL‐10 producing T cells are associated with a reduced incidence of allergic sensitization. Once allergic sensitization or eczema is established, CD4+CD25+FoxP3+ T‐reg cells expand to potentially counteract the allergic inflammatory response. Understanding the relationship between development of immunoregulatory T cells and early onset atopy could lead to new preventive strategies for allergic diseases. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5399766 Tue, 01 Nov 2011 04:00:00 +0100 5399766 http://www.medworm.com/index.php?rid=5334710&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03890.x Conclusions and Clinical RelevanceThis synbiotic mixture has no detectable effect on plasma levels of the analysed atopic disease markers, ex vivo cytokine production and circulating regulatory T cell percentage in infants with atopic dermatitis, besides down‐regulation of IL‐12 production in egg‐ and peanut‐stimulated PBMCs. These results do not support the use of this synbiotic in clinical practice. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5334710 Fri, 21 Oct 2011 22:43:15 +0100 5334710 http://www.medworm.com/index.php?rid=5334712&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03885.x Conclusion and Clinical RelevanceWe found no benefit from supplementation with B. lactis or L. paracasei in the treatment of eczema, when given as an adjunct to basic topical treatment, and no effect on the progression of allergic disease from age 1 to 3 years. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5334712 Tue, 18 Oct 2011 04:00:00 +0100 5334712 http://www.medworm.com/index.php?rid=5334711&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03888.x Conclusions and Clinical RelevanceThese data indicate that grass pollen is colonized by several microorganisms that influence the immune response differently. Similar to LPS, supernatants of homogenized Gram‐positive bacteria may serve as adjuvants by augmenting DC maturation and inflammatory Th1, Th2 and Th17 responses helping to initiate allergic immune responses. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5334711 Tue, 18 Oct 2011 04:00:00 +0100 5334711 http://www.medworm.com/index.php?rid=5313598&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03870.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5313598 Fri, 14 Oct 2011 22:45:14 +0100 5313598 http://www.medworm.com/index.php?rid=5313597&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03844.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5313597 Fri, 14 Oct 2011 22:44:47 +0100 5313597 http://www.medworm.com/index.php?rid=5313596&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03837.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5313596 Fri, 14 Oct 2011 22:44:45 +0100 5313596 http://www.medworm.com/index.php?rid=5313595&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2009.03883.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5313595 Fri, 14 Oct 2011 22:44:43 +0100 5313595 http://www.medworm.com/index.php?rid=5313593&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03889.x Conclusions and Clinical RelevanceIL‐4 and IL‐13 prime the migrational response of HPC to SDF‐1α by enhancing the incorporation of CXCR4 into lipid rafts. The priming effect of these cytokines is specific to primitive HPC. These data suggest that increased local production of IL‐4 and IL‐13 within the lungs may promote increased SDF‐1α mediated homing of HPC to the airways in asthma. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5313593 Fri, 14 Oct 2011 22:43:32 +0100 5313593 http://www.medworm.com/index.php?rid=5313594&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03887.x Conclusion and Clinical RelevanceSuspicions of DHRs are less likely to be confirmed in children. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5313594 Thu, 13 Oct 2011 04:00:00 +0100 5313594 http://www.medworm.com/index.php?rid=5303776&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03886.x Conclusions and Clinical RelevanceCompared with non‐asthmatics, asthmatic children exhibited increased chitinase activity and increased YKL‐40 levels in BALF. Increased IgG and IgA reactivity to fungal proteins in the BALF of asthmatics may reflect a local response to fungal infection. Our findings are consistent with and suggest a role for chitinases in asthma pathogenesis among Bronx children and provide serological evidence of an association between fungal infection and severe asthma. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5303776 Mon, 10 Oct 2011 04:00:00 +0100 5303776 http://www.medworm.com/index.php?rid=5303775&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03880.x Conclusions and Clinical RelevanceSignificant associations of obesity and aspirin intolerance with DTA were observed only in women and in non‐atopics. These findings suggest that a phenotype‐specific approach is needed to treat patients with DTA. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5303775 Mon, 10 Oct 2011 04:00:00 +0100 5303775 http://www.medworm.com/index.php?rid=5303774&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03879.x Conclusions and Clinical RelevanceLevels of vitamin D metabolites, particularly 1,25(OH)2D, were low within the airways and increased after allergen challenge. The increases correlated with the magnitude of inflammation and increases in cathelicidin. Normalization to albumin suggested plasma exudation as a mechanism for the increases. The findings support a role for vitamin D in allergic and innate immune responses in the lung. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5303774 Mon, 10 Oct 2011 04:00:00 +0100 5303774 http://www.medworm.com/index.php?rid=5296274&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03881.x SummaryHuman leucocyte antigen‐G (HLA‐G) is a non‐classical HLA class I molecule demonstrated originally in placental trophoblast cells. Recognition of the importance of HLA‐G to the maternal immune accommodation of the semi‐allogeneic fetus has led to investigations of its role in the suppression of immune responses and induction of tolerance. More recently, HLA‐G has been shown to have increased expression in several immunological diseases including asthma and allergic rhinitis. The focus of this review is the potential role of HLA‐G in immunological airway diseases. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5296274 Thu, 06 Oct 2011 04:00:00 +0100 5296274 http://www.medworm.com/index.php?rid=5296273&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03874.x Conclusions and Clinical RelevanceThe P2RY12 variants were associated with lung function in a large family‐based asthma cohort. House dust mite exposure caused significant gene‐by‐environment effects. Our findings add the first human evidence to experimental data supporting a role for P2Y12 in lung function. P2Y12 could represent a novel target for asthma treatment. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5296273 Thu, 06 Oct 2011 04:00:00 +0100 5296273 http://www.medworm.com/index.php?rid=5303773&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03878.x SummaryAlthough immediate‐Type I skin reactions to human dander have been described six decades ago, only the recent application of molecular biology to allergology research allowed fast and detailed characterization of IgE‐binding autoantigens. These can be functionally subdivided into three classes: (1) self‐antigens with sequence homology to environmental allergens belonging to the class of phylogenetically conserved proteins, (2) self‐antigens without sequence homology to known environmental allergens, and (3) chemically modified self‐antigens deriving from workplace exposure. As environmental allergens, also IgE‐binding autoantigens belong to different protein families without common structural features that would explain their IgE‐binding capability. Many of the self‐... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5303773 Sat, 01 Oct 2011 04:00:00 +0100 5303773 http://www.medworm.com/index.php?rid=5296272&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03875.x Conclusions and Clinical RelevanceWith the largest number of LTT performed in patients with SJS or TEN to a single drug, we confirmed that reactive cells are rarely detected in these reactions. Poor reactivity did not seem related to T‐reg. Other in vitro assays than those testing proliferation should be evaluated, before raising the hypothesis that specific cells disappeared by undergoing apoptosis during the reaction. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5296272 Sat, 01 Oct 2011 04:00:00 +0100 5296272 http://www.medworm.com/index.php?rid=5259765&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03860.x Conclusions and Clinical RelevanceThese data suggest that while iNOS expression from epithelial brushings is highest in severe asthma, factors controlling arginase2 mRNA expression significantly improve differentiation of severity. In contrast, functionality of the NO pathway as measured by FeNO, NT and eosinophilic inflammation, is strongly associated with iNOS expression alone, particularly in severe asthma. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5259765 Wed, 28 Sep 2011 22:43:31 +0100 5259765 http://www.medworm.com/index.php?rid=5249927&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03850.x Conclusions and Clinical RelevanceOur data suggest that the association between antibiotics and asthma is subject to either reverse causation or confounding by indication due to respiratory tract infections. This implies that careful consideration is required as to whether or not symptoms from the respiratory tract in early childhood should be treated with antibiotics or asthma medication. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5249927 Sun, 25 Sep 2011 06:46:24 +0100 5249927 http://www.medworm.com/index.php?rid=5259766&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03873.x Conclusions and Clinical RelevanceIn contrast to self‐identified race, African ancestry remained a significant, independent predictor of early childhood wheezing after accounting for early life and other known risk factors associated with lung function changes and asthma. Genetic ancestry may be a powerful way to evaluate wheezing disparities and a proxy for differentially distributed genetic and early life risk factors associated with childhood recurrent wheezing. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5259766 Sun, 25 Sep 2011 04:00:00 +0100 5259766 http://www.medworm.com/index.php?rid=5249931&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03867.x Conclusions and Clinical RelevanceThe IL‐33 and its receptor ST2 play important roles in allergic rhinitis. The IL‐33‐mediated inflammatory responses via ST2 are regulated by distinct signalling pathways in HNECs and the IL‐33/ST2 pathway may provide new therapeutic targets for allergic rhinitis. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5249931 Fri, 23 Sep 2011 04:00:00 +0100 5249931 http://www.medworm.com/index.php?rid=5249930&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03866.x Conclusions and Clinical RelevanceThe data suggest that Bet v 1‐like allergens of the Betuloideae and Coryloideae subfamily might have the potential to induce IgE antibodies with different specificities, while allergic reactions towards Fagaceae allergens are the result of IgE cross‐reactivity. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5249930 Fri, 23 Sep 2011 04:00:00 +0100 5249930 http://www.medworm.com/index.php?rid=5249929&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03865.x Conclusions and Clinical RelevanceThe efficacy of a sublingual vaccine based on a Dpte/Dfar allergen extract mix was demonstrated in a well standardized murine model of chronic allergic airway inflammation based on clinically relevant mite allergens. The latter will be used as a benchmark for evaluation of future vaccines, including recombinant allergens. This HDM allergic airway inflammation animal model is a useful tool to design and select candidate vaccines to be tested in humans. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5249929 Fri, 23 Sep 2011 04:00:00 +0100 5249929 http://www.medworm.com/index.php?rid=5249928&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03854.x SummaryInterleukin‐5 is a Th2 homodimeric cytokine involved in the differentiation, maturation, migration, development, survival, trafficking and effector function of blood and local tissue eosinophils, in addition to basophils and mast cells.The IL‐5 receptor (IL‐5R) consists of an IL‐5‐specific α subunit that interacts in conformationally dynamic ways with the receptor's βc subunit, an aggregate of domains it shares with binding sites of IL‐3 and granulocyte‐macrophage colony‐stimulating factor. IL‐5 and IL‐5R drive allergic and inflammatory immune responses characterizing numerous diseases, such as asthma, atopic dermatitis, chronic obstructive pulmonary disease, eosinophilic gastrointestinal diseases, hyper‐eosinophilic syndrome, Churg‐Strauss syndrome and eos... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5249928 Fri, 23 Sep 2011 04:00:00 +0100 5249928 http://www.medworm.com/index.php?rid=5236393&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03849.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236393 Wed, 21 Sep 2011 15:34:13 +0100 5236393 http://www.medworm.com/index.php?rid=5236392&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03828.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236392 Wed, 21 Sep 2011 15:34:11 +0100 5236392 http://www.medworm.com/index.php?rid=5236391&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03842.x This article reviews recent literature and provides an updated guideline for immunization during the 2011–2012 flu season. Recent experience suggests that some vaccines with very low ovalbumin concentrations may be safe for use in primary care in carefully assessed low‐risk individuals.Cite this as: M. Erlewyn‐Lajeunesse, J. S. A. Lucas and J. O. Warner, Clinical & Experimental Allergy, 2011 (41) 1367‐1370. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236391 Wed, 21 Sep 2011 15:33:47 +0100 5236391 http://www.medworm.com/index.php?rid=5236390&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03810.x Cite this as: H. Smith, Clinical & Experimental Allergy, 2011 (41) 1344–1345. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236390 Wed, 21 Sep 2011 15:33:42 +0100 5236390 http://www.medworm.com/index.php?rid=5236389&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03764.x Cite this as: E. Jensen‐Jarolim and J. Singer, Clinical & Experimental Allergy, 2011 (41) 1337–1340. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236389 Wed, 21 Sep 2011 15:33:38 +0100 5236389 http://www.medworm.com/index.php?rid=5236388&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03851.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236388 Wed, 21 Sep 2011 15:33:36 +0100 5236388 http://www.medworm.com/index.php?rid=5236387&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2009.03856.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236387 Wed, 21 Sep 2011 15:33:35 +0100 5236387 http://www.medworm.com/index.php?rid=5236373&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03864.x Conclusions and Clinical RelevanceEndogenous human milk epitopes are recognized by specific IgE from the majority of infants and children with CMA. Such autoreactive, human milk‐specific IgE antibodies appear to have functional properties in vitro. Their role in provoking allergic symptoms in infants exclusively breastfed by mothers strictly avoiding dietary milk remains unclear. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236373 Wed, 21 Sep 2011 15:32:19 +0100 5236373 http://www.medworm.com/index.php?rid=5236377&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03859.x Conclusions and Clinical RelevanceAnaphylaxis was seen significantly more in boys. Most of the reactions occurred at home. Foods were the most frequent cause. Epinephrine, the first‐line treatment of anaphylaxis, was administered in only a third of the children. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236377 Wed, 21 Sep 2011 04:00:00 +0100 5236377 http://www.medworm.com/index.php?rid=5236376&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03861.x Conclusions and Clinical RelevanceThese results identify that in the skin environment, the presence of SEB can significantly increase the numbers of allergen‐induced Th2 cells which develop in response to subsequent allergen exposure. These data highlight the process by which individuals may become pathologically sensitized to food allergens in early life. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236376 Wed, 21 Sep 2011 04:00:00 +0100 5236376 http://www.medworm.com/index.php?rid=5236375&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03862.x SummaryPatch testing is a standardized, in vivo diagnostic test for type IV hypersensitivity reactions, resulting in allergic contact dermatitis, which clinically resembles eczema. Common allergens include fragrance chemicals, hair dyes, metals, rubber accelerators and preservatives. Known allergens at particular concentrations in optimal vehicles are tested on the upper back under occlusion for 2 days. Readings according to international criteria are usually performed on days 2 and 4. Irritant reactions can closely resemble allergic ones, and further tests may be necessary to discriminate. Interpretation of the relevance of the reactions can also be difficult, perhaps requiring repeated open application testing, work‐site visits etc. Monitoring of trends in patch test positivity can be... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236375 Wed, 21 Sep 2011 04:00:00 +0100 5236375 http://www.medworm.com/index.php?rid=5236374&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03863.x Conclusion and clinical relevanceObesity in inner‐city adults may be both a risk and exacerbating factor for atopic asthma. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236374 Wed, 21 Sep 2011 04:00:00 +0100 5236374 http://www.medworm.com/index.php?rid=5236386&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03852.x Conclusion and Clinical RelevanceDex at therapeutic concentrations did not inhibit the effects of IL‐13 on goblet cell differentiation, characteristic of severe asthma. Paradoxically, MUC5AC production was increased with lower dose IL‐13 exposure. This may lead to airway mucus obstruction commonly seen in life‐threatening asthma. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236386 Tue, 20 Sep 2011 04:00:00 +0100 5236386 http://www.medworm.com/index.php?rid=5236384&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03853.x Conclusions and Clinical RelevanceThese data suggest that topical application of the STAT‐6‐IP is sufficient to inhibit allergic airways responses in animals chronically sensitized and challenged with ragweed. Data show that a single topical treatment course is sufficient to block signs of allergic responses to ragweed in the airways for at least 2 weeks. STAT‐6‐IP is a novel potential treatment for chronic allergic asthma. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236384 Tue, 20 Sep 2011 04:00:00 +0100 5236384 http://www.medworm.com/index.php?rid=5236383&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03855.x ConclusionsIn conclusion, ANXA1−/− mice possess multiple features characteristic to allergic asthma, such as airway hyperresponsiveness and enhanced antibody responses, suggesting that ANXA1 plays a critical regulatory role in the development of asthma.Clinical RelevanceWe postulate that ANXA1 is an important regulatory factor in the development of allergic disease and dysregulation of its expression can lead to pathological changes which may affect disease progression. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236383 Tue, 20 Sep 2011 04:00:00 +0100 5236383 http://www.medworm.com/index.php?rid=5236382&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03857.x Conclusions and Clinical RelevanceAtopic dermatitis, but not RSV LRTI, is associated with distinct pre‐symptomatic differences in the innate immune system. We hypothesize that decreased neonatal IL‐10‐mediated immune regulation during early life might play a causal role in the initiation of AD. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236382 Tue, 20 Sep 2011 04:00:00 +0100 5236382 http://www.medworm.com/index.php?rid=5236381&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03858.x Conclusion and Clinical RelevanceIn this single dose allergen provocation study, AKC patients responded with a typical IgE‐mediated allergic reaction. An increase in cytokines at 48 h after the challenge was demonstrated and might, with further studies, give us a better understanding of the nature of inflammation in AKC. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236381 Tue, 20 Sep 2011 04:00:00 +0100 5236381 http://www.medworm.com/index.php?rid=5236380&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03868.x Conclusions and Clinical RelevanceTwo concrete actions were suggested: (1) Action levels should be derived from the data currently available. Different scenarios should be examined and further developed in an iterative process. On the basis of this work, a tolerable level of risk should be proposed. (2) ‘One‐dose’ clinical trial with a low challenge dose should be performed in multiple centres to provide additional information about the general applicability of dose‐distribution models and help validate the threshold levels derived. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236380 Tue, 20 Sep 2011 04:00:00 +0100 5236380 http://www.medworm.com/index.php?rid=5236379&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03869.x Conclusions and clinical relevanceThe components of immune tolerance machinery, TolDCs and Tregs were suppressed in the AR nasal mucosa. The increases in SEB and decreases in avb6 in nasal epithelium are associated with the compromises of immune tolerance in the nasal mucosa. SEB has the ability to suppress the expression of avb6 in nasal epithelial cells. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5236379 Tue, 20 Sep 2011 04:00:00 +0100 5236379 http://www.medworm.com/index.php?rid=5182969&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03846.x Conclusion and Clinical RelevanceIn this cohort of patients with IgE‐mediated reactions to cefazolin, a majority tolerated amoxicillin and several patients tolerated other cephalosporins. This implies that the R1 side‐chain may play an essential role in IgE‐mediated reactions to cefazolin. No clear rule to predict cross‐reactivity with other ß‐lactams could be determined. More research on IgE‐mediated hypersensitivity to cefazolin and other cephalosporins is needed. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5182969 Wed, 31 Aug 2011 23:00:00 +0100 5182969 http://www.medworm.com/index.php?rid=5182968&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03845.x Conclusions and Clinical RelevanceOur findings clearly show that immunotherapy with DNA encoding Hsp65 can attenuate an established Th2 allergic inflammation through an IL‐10‐dependent mechanism; moreover, the migration of allergen‐ and Hsp65‐specific cells to the allergic sites exerts a fundamental role. This work represents a novel contribution to the understanding of immune regulation by Hsp65 in allergic diseases. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5182968 Wed, 31 Aug 2011 23:00:00 +0100 5182968 http://www.medworm.com/index.php?rid=5182967&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03847.x Conclusions and Clinical RelevanceThere were notable differences in allergic lung inflammation mediated by different T cell subsets. CCR4 blockage was selectively effective for suppression of Th2‐mediated allergic inflammation by blocking infiltration of Th2 cells. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5182967 Wed, 31 Aug 2011 23:00:00 +0100 5182967 http://www.medworm.com/index.php?rid=5182966&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03848.x Conclusions and Clinical RelevanceSerum tryptase values obtained during a suspected hypersensitivity reaction must always be compared to a baseline value. A relative tryptase increase to ≥135% of the baseline value during a suspected hypersensitivity reaction indicates mast cell activation even below 11.4 ng/mL. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5182966 Wed, 31 Aug 2011 23:00:00 +0100 5182966 http://www.medworm.com/index.php?rid=5160548&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03825.x SummaryAdverse reactions to drugs are increasingly being recognized as important contributions to disease in their own right as well as impediments to the best treatment of various conditions, including infectious, autoimmune, and neoplastic maladies. Rapid drug desensitization (RDD) is an effective mechanism for safely administering important medications while minimizing or entirely circumventing such adverse reactions in sensitized patients. We reviewed the literature on RDD in the last 10 years, including our experience from the Brigham and Women's Hospital Desensitization Program with hundreds of patients desensitized to a broad variety of drugs. RDD in our programme has been uniformly successful in patients with hypersensitivity reactions to antibiotics, chemotherapeutics, and monoclo... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5160548 Sat, 27 Aug 2011 12:08:23 +0100 5160548 http://www.medworm.com/index.php?rid=5160552&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03841.x Conclusions and Clinical RelevanceTomato cultivars promote a distinct clinical reactivity in tomato allergic subjects, demonstrated using SPT, DBPCFC and BAT. The molecular background for these differences could not be clarified, as the IgE‐binding profiles did not reveal significant alterations. This might be due to instabilities of physicochemical sensitive proteins and/or different isoform expression of allergens. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5160552 Sun, 21 Aug 2011 23:00:00 +0100 5160552 http://www.medworm.com/index.php?rid=5160551&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03838.x Conclusion and Clinical RelevanceAllergic rhinitis symptoms are significantly associated with allergen‐specific basophile sensitivity. In vitro evaluation of basophile sensitivity should prove useful for distinguishing clinical phenotype of allergic sensitization. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5160551 Sun, 21 Aug 2011 23:00:00 +0100 5160551 http://www.medworm.com/index.php?rid=5160550&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03839.x Conclusions and Clinical RelevanceWe have demonstrated for the first time that urinary 15‐epi‐LXA4 concentration is significantly higher than LXA4 concentration in both the AIA and ATA groups. 15‐Epi‐LXA4 concentration was significantly lower in the AIA group with an increased urinary LTE4 concentration than in the ATA group. An imbalance between proinflammatory cysteinyl‐leukotrienes and anti‐inflammatory 15‐epi‐LXA4 may be involved in AIA pathogenesis. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5160550 Sun, 21 Aug 2011 23:00:00 +0100 5160550 http://www.medworm.com/index.php?rid=5160549&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03840.x Conclusions and Clinical RelevanceAllergen‐induced increases in serum IgE and bronchial hyperresponsiveness are exaggerated in periostin deficient mice challenged with inhaled aeroallergen. The mechanism of periostin's effect as a brake on allergen‐induced responses may involve augmentation of TGF‐β‐induced T regulatory cell differentiation. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5160549 Sun, 21 Aug 2011 23:00:00 +0100 5160549 http://www.medworm.com/index.php?rid=5142822&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03829.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5142822 Sat, 20 Aug 2011 12:08:58 +0100 5142822 http://www.medworm.com/index.php?rid=5142821&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03835.x Conclusions and Clinical Relevance. SLIT is effective in reducing total and individual ocular symptom scores in subjects with ARC or conjunctivitis. No significant reduction was observed in ocular eye drops use.Cite this as: M. A. Calderon, M. Penagos, A. Sheikh, G. W. Canonica and S. R. Durham, Clinical & Experimental Allergy, 2011 (41) 1263–1272. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5142821 Sat, 20 Aug 2011 12:08:52 +0100 5142821 http://www.medworm.com/index.php?rid=5142820&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03788.x SummaryThis guidance for the management of patients with hymenoptera venom allergy has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is for use by both adult physicians and pediatricians practising allergy. During the development of these guidelines, all BSACI members were included in the consultation process using a web‐based system. Their comments and suggestions were carefully considered by the SOCC. Where evidence was lacking, consensus was reached by the experts on the committee. Included in this guideline are epidemiology, risk factors, clinical features, diagnostic tests, natural history of hymenoptera venom allergy and guidance on under... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5142820 Sat, 20 Aug 2011 12:08:48 +0100 5142820 http://www.medworm.com/index.php?rid=5142819&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03794.x SummaryAllergic rhinitis (AR) affects more than 20% of the population in the United Kingdom and western Europe and represents a major cause of morbidity that includes interference with usual daily activities and impairment of sleep quality. This guidance prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI) is for the management of AR in patients that have failed to achieve adequate relief of symptoms despite treatment with intranasal corticosteroids and/or antihistamines. The guideline is based on evidence and is for use by both adult physicians and paediatricians practising allergy. During the development of these guidelines, all BSACI members were included in the consultation process using a web‐based system. Their commen... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5142819 Sat, 20 Aug 2011 12:08:47 +0100 5142819 http://www.medworm.com/index.php?rid=5142818&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03799.x Cite this as: C. A. Keet and R. A. Wood, Clinical & Experimental Allergy, 2011 (41) 1175–1176. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5142818 Sat, 20 Aug 2011 12:08:46 +0100 5142818 http://www.medworm.com/index.php?rid=5142817&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03737.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5142817 Sat, 20 Aug 2011 12:08:45 +0100 5142817 http://www.medworm.com/index.php?rid=5142816&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2009.03843.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5142816 Sat, 20 Aug 2011 12:08:45 +0100 5142816 http://www.medworm.com/index.php?rid=5095955&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03832.x Conclusions and Clinical Relevance In the relatively affluent school, asthma/wheezing and EIB were associated with high titre IgE antibodies to mite, decreased total IgE, and increased BMI. This contrasted with children in the urban poor school and suggests that changes relevant to a Western model of childhood asthma can occur within a short geographical distance within a large city in Africa. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5095955 Mon, 01 Aug 2011 23:00:00 +0100 5095955 http://www.medworm.com/index.php?rid=5119407&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03831.x Conclusion and Clinical Relevance Among young children in a developing country, we found evidence to support the hypothesis of a protective effect of H. pylori infection on the risk of allergic disease. Further investigation of the mechanism of this effect is therefore of potential therapeutic and preventive value. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5119407 Sun, 31 Jul 2011 23:00:00 +0100 5119407 http://www.medworm.com/index.php?rid=5095952&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03834.x Conclusions This study shows that DIA‐AX is equivalent to INJ‐AX in terms of skin test response, as well as with in vitro immunochemical and biological tests. DIA‐AX can therefore be used in the diagnosis of immediate hypersensitivity reactions. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5095952 Sun, 31 Jul 2011 23:00:00 +0100 5095952 http://www.medworm.com/index.php?rid=5086702&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03827.x Conclusion and Clinical Relevance Allergic disease and sensitization in infancy was associated with low circulating Th1‐ and high Th2‐associated chemokine levels already from birth. Circulating chemokines are useful for investigating the Th1/Th2 imbalance in allergic disease in vivo. Elucidation of the role of chemokines in allergic diseases may lead to future treatments (ClinicalTrials.gov NCT01285830). (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5086702 Sun, 31 Jul 2011 23:00:00 +0100 5086702 http://www.medworm.com/index.php?rid=5086701&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03824.x Conclusions and Clinical Relevance We showed no evidence for a role of hs‐CRP, C3 and C4 in the association between BMI and asthma symptoms. C3 concentrations were associated with (frequent) asthma symptoms, independent of BMI. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5086701 Sun, 31 Jul 2011 23:00:00 +0100 5086701 http://www.medworm.com/index.php?rid=5086700&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03830.x Conclusions and Clinical Relevance Extensive heating reduced the degranulation capacity of Ara h 2/6 but significantly increased the degranulation capacity of Ara h 1. This observation can have important ramifications for component‐resolved approaches for diagnosis and demonstrates the importance of investigating the degranulation capacity in addition to IgE reactivity when assessing the effects of food processing on the allergenicity of proteins. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5086700 Sun, 31 Jul 2011 23:00:00 +0100 5086700 http://www.medworm.com/index.php?rid=5086699&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03836.x Conclusion and Clinical Relevance Expression of the pulmonary epithelium‐derived CC‐type chemokine genes in the cluster is orchestrated by the conserved machinery related to Bcl6. Thus, Bcl6 in pulmonary epithelium may be a critical regulator for pathogenesis of various pulmonary inflammatory diseases. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5086699 Sun, 31 Jul 2011 23:00:00 +0100 5086699 http://www.medworm.com/index.php?rid=5063016&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03833.x Conclusions & Clinical Relevance The association between dietary intake of fatty acids and allergic diseases might be modulated by FADS gene variants in children. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5063016 Tue, 26 Jul 2011 13:53:50 +0100 5063016 http://www.medworm.com/index.php?rid=5052047&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03808.x Conclusion and Clinical Relevance The conformation of LTP1 appeared to have a strong impact on the type of IgE‐binding epitopes elicited by this protein in both man and mouse. The responses in mice sensitized to gliadins or LTP1 were sufficiently comparable with the human response in terms of IgE‐binding epitopes to provide support for the use of the mouse model in further investigations. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5052047 Sat, 23 Jul 2011 13:53:42 +0100 5052047 http://www.medworm.com/index.php?rid=5052049&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03821.x Conclusion and Clinical Relevance Allergy was associated with more intense IgA and IgG responses to OVA. Breastfeeding depressed humoral responses, whereas prebiotics and probiotics supplementation showed no immunomodulatory effect. The effect of probiotics on allergies is not mediated through food‐specific antibody responses. Furthermore, OVA‐specific IgA and IgG antibodies may help in assessing the risk for atopy. [Trial registration: Clinicaltrials.gov NCT00298337] (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5052049 Mon, 18 Jul 2011 23:00:00 +0100 5052049 http://www.medworm.com/index.php?rid=5052048&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03823.x SummaryFood allergy is a growing clinical and public health problem world‐wide. The rising incidence is occurring more rapidly than changes to the genome sequence would allow, but it is yet to be determined whether environmental factors might act in interaction with genetic risk. That is to say, are environmental factors more likely to affect those genetically at risk? Family history is a strong risk factor for the development of food allergy as it co‐aggregates with other atopic diseases and as such genetic factors do play an important role in food allergy risk. However, significant interest has now turned to the role of epigenetic modifications of the genome as the major mediator of gene–environment interaction. The consideration of the role of epigenetics in food allergy is likely... Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5052048 Mon, 18 Jul 2011 23:00:00 +0100 5052048 http://www.medworm.com/index.php?rid=5029678&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03809.x (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5029678 Sat, 16 Jul 2011 13:54:24 +0100 5029678 http://www.medworm.com/index.php?rid=5029677&cid=s_33165_3_f&fid=33165&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2222.2011.03815.x Cite this as: C. E. Kuehni, Clinical & Experimental Allergy, 2011 (41) 1054–1058. (Source: Clinical and Experimental Allergy) Clinical and Experimental Allergy journals http://www.medworm.com/rss/comments.php?id=5029677 Sat, 16 Jul 2011 13:54:17 +0100 5029677