MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical and Investigative Medicine' source. Thu, 09 Feb 2012 14:07:50 +0100 http://www.medworm.com/index.php?rid=5671709&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22309959%26dopt%3DAbstract Conclusion: PG2 might be an effective and safe treatment for relieving CRF among advanced cancer patients. PMID: 22309959 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5671709 Thu, 09 Feb 2012 11:54:09 +0100 5671709 http://www.medworm.com/index.php?rid=5671708&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22309960%26dopt%3DAbstract Conclusion: PWD values, which were higher than 51 ms and 51.6 ms in patients who received fibrinolytic therapy, can serve as a marker of failed reperfusion and occluded IRA. PWD values, in combination with other reperfusion parameters, can contribute to the identification of rescue PCI candidates. PMID: 22309960 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5671708 Thu, 09 Feb 2012 11:54:09 +0100 5671708 http://www.medworm.com/index.php?rid=5671707&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22309961%26dopt%3DAbstract Conclusion: Young patients with yet untreated primary hypertension have lower circulating serum sTWEAK level compared with healthy controls. Further research for possible associations among serum sTWEAK, endothelial dysfunction and other measures of atherosclerosis may be of benefit in order to better understand the pathophysiology of hypertension and to establish more effective treatment options. PMID: 22309961 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5671707 Thu, 09 Feb 2012 11:54:09 +0100 5671707 http://www.medworm.com/index.php?rid=5671706&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22309962%26dopt%3DAbstract Conclusion: Based on the size of population studied, this study showed a prevalence of acromegaly of 29 per million. The cure rate was low following surgery but with adjuvant medical treatment disease control was achieved in most individuals. PMID: 22309962 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5671706 Thu, 09 Feb 2012 11:54:09 +0100 5671706 http://www.medworm.com/index.php?rid=5671705&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22309963%26dopt%3DAbstract Conclusion: The data from this study suggest, for the first time, that CD55 is frequently expressed in nasopharyngeal carcinoma and its expression is associated with decreased patient survival; therefore, CD55 expression may be a potential unfavorable prognostic factor for patients with nasopharyngeal carcinoma. PMID: 22309963 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5671705 Thu, 09 Feb 2012 11:54:09 +0100 5671705 http://www.medworm.com/index.php?rid=5671704&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22309964%26dopt%3DAbstract Conclusion: Medical residents at our institution appear less active and consume fewer servings of fruits and vegetables than undergraduate medical students. These differences are associated with higher BMI, waist circumference and cardiovascular risk. PMID: 22309964 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5671704 Thu, 09 Feb 2012 11:54:09 +0100 5671704 http://www.medworm.com/index.php?rid=5470978&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129918%26dopt%3DAbstract Authors: Borden KL Abstract Identifying and targeting specific oncogenes, with the hope that the resultant therapies may eventually prove to exert positive clinical effects, is a major effort in the area of cancer therapeutics. The eukaryotic translation initiation factor, eIF4E, is overexpressed in many cancers, including acute myeloid leukemia. The role of eIF4E in oncogenic transformation and the development of a means to directly target its activity with ribavirin are discussed here. Results from early stage clinical trials and factors contributing to the development of clinical resistance to ribavirin are also described. PMID: 22129918 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470978 Sun, 04 Dec 2011 21:30:02 +0100 5470978 http://www.medworm.com/index.php?rid=5470977&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129919%26dopt%3DAbstract Authors: Zipursky A Abstract When it comes to global health, there is no 'them'... only 'us.'" - Global Health Council There is a major anomaly in child health research. The majority of pediatric research resources and expertise is located in the developed world, whereas the vast majority of childhood disease and mortality is in the developing world. This disequilibrium has been referred to as the "10/90 gap", suggesting that only 10% of global health research dollars are devoted to conditions that account for 90% of the global disease burden (Global Forum for Health Research). The Programme for Global Paediatric Research (PGPR) began as an effort to include, in a major pediatric research conference, topics dealing with diseases of children in the developing world in order to engag... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470977 Sun, 04 Dec 2011 21:30:02 +0100 5470977 http://www.medworm.com/index.php?rid=5470976&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129920%26dopt%3DAbstract Authors: Bossé D, Milger K, Morty RE Abstract Clinician-scientists are particularly well positioned to bring basic science findings to the patient's bedside; the ultimate objective of basic research in the health sciences. Concerns have recently been raised about the decreasing workforce of clinician-scientists in both the United States of America and in Canada; however, little is known about clinician-scientists elsewhere around the globe. The purpose of this article is two-fold: 1) to feature clinician-scientist training in Germany; and 2) to provide a comparison with the Canadian system. In a question/answer interview, Rory E. Morty, director of a leading clinician-scientist training program in Germany, and Katrin Milger, a physician and graduate from that program, draw a pictu... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470976 Sun, 04 Dec 2011 21:30:02 +0100 5470976 http://www.medworm.com/index.php?rid=5470975&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129921%26dopt%3DAbstract Conclusions: Increased MPV on admission can be associated with degree of left ventricle systolic depression in patients with metabolic syndrome with first ST-elevation myocardial infarction. MPV may prove to be useful as a prognostic marker in patients with metabolic syndrome and ST elevation MI. PMID: 22129921 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470975 Sun, 04 Dec 2011 21:30:02 +0100 5470975 http://www.medworm.com/index.php?rid=5470974&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129922%26dopt%3DAbstract Conclusions: Fibrin glue can be used in cavernoseal surgeries due to its adhesive and potentially anti-inflammatory features. PMID: 22129922 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470974 Sun, 04 Dec 2011 21:30:02 +0100 5470974 http://www.medworm.com/index.php?rid=5470973&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129923%26dopt%3DAbstract Authors: Collisson BA, Benzies K, Mosher AA, Rainey KJ, Tanaka S, Tracey C, Xu C, Olson DM Abstract Within a dynamic health research environment with trends toward increasing accountability, governments and funding agencies have placed increased emphasis on knowledge translation (KT) as a way to optimize the impact of research investments on health outcomes, research products and health service delivery. As a result, there is an increasing need for familiarity with the principles of KT frameworks and components of KT strategies. Accordingly, health research trainees (graduate students and post-doctoral fellows) must be supported to enhance their capacity to understand KT principles and the practicalities of implementing effective KT practices.In this paper, the unique opportunities... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470973 Sun, 04 Dec 2011 21:30:02 +0100 5470973 http://www.medworm.com/index.php?rid=5470972&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129924%26dopt%3DAbstract Conclusion: Sirolimus was effective in BLM-induced pulmonary fibrosis model, especially in the early phases of the disease. PMID: 22129924 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470972 Sun, 04 Dec 2011 21:30:02 +0100 5470972 http://www.medworm.com/index.php?rid=5470971&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129925%26dopt%3DAbstract Conclusion: HRV and HRT parameters may provide additional information for discriminating between patients who do and do not truly need CA. PMID: 22129925 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470971 Sun, 04 Dec 2011 21:30:02 +0100 5470971 http://www.medworm.com/index.php?rid=5470970&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129926%26dopt%3DAbstract Conclusion: Over-expression of EMMPRIN correlated with the aggressiveness of PCa, and the PSA relapse-free time, and may be a novel and useful biomarker for follow-up and treatment decisions for PCa. PMID: 22129926 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470970 Sun, 04 Dec 2011 21:30:02 +0100 5470970 http://www.medworm.com/index.php?rid=5470969&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129927%26dopt%3DAbstract Conclusion: Our results indicate that the gene haplotype of IL-10 can contribute to the susceptibility to AS in a Chinese population. PMID: 22129927 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470969 Sun, 04 Dec 2011 21:30:02 +0100 5470969 http://www.medworm.com/index.php?rid=5470968&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129928%26dopt%3DAbstract Conclusion: Vitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance. PMID: 22129928 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5470968 Sun, 04 Dec 2011 21:30:02 +0100 5470968 http://www.medworm.com/index.php?rid=5293649&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968266%26dopt%3DAbstract Authors: Boozary A, Dugani SB Abstract The World Health Organization (WHO) defines health as a "resource for everyday living, not the objective of living"; however, worldwide, there remains an unmistakable inequity in level of health and access to healthcare. The WHO has published documents on financing health systems towards universal health coverage [1], promoting healthy life [2], improving performance of health systems [3], and enriching humanity [4], highlighting our shared responsibility towards improving both national and global health and access to healthcare. These documents also recognize that, despite our local and regional priorities, there is a global desire to develop international strategies to improve healthcare. [1] WHO Report. Health systems financing and the pat... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293649 Fri, 07 Oct 2011 22:45:02 +0100 5293649 http://www.medworm.com/index.php?rid=5293648&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968267%26dopt%3DAbstract Conclusion: CXCL10 participates in the early inflammatory response after radioactive iodine therapy in patients with Graves' disease and shows a strong association with the autoimmune process. PMID: 21968267 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293648 Fri, 07 Oct 2011 22:45:02 +0100 5293648 http://www.medworm.com/index.php?rid=5293647&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968268%26dopt%3DAbstract Conclusion: Serum OC and NTx levels may be useful markers of serum iPTH levels for evaluating bone turnover in HD patients and may eventually prove useful in the management of patients with CKD-MBD. PMID: 21968268 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293647 Fri, 07 Oct 2011 22:45:02 +0100 5293647 http://www.medworm.com/index.php?rid=5293646&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968269%26dopt%3DAbstract Conclusion: Levobupivacaine's myotoxic effect is qualitatively similar to that seen (and previously reported) with bupivacaine and ropivacaine. Levobupivacaine was found to be quantitatively less myotoxic than bupivacaine and ropivacaine after a single intramuscular injection, only two days after injection. Myonecrosis developed after a single intramuscular injection of local anesthetic but was completely regenerated by the 20th day after injection. PMID: 21968269 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293646 Fri, 07 Oct 2011 22:45:02 +0100 5293646 http://www.medworm.com/index.php?rid=5293645&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968270%26dopt%3DAbstract Authors: Lou Y, Cui Z, Wang F, Yang X, Qian J Abstract Purpose: To investigate the influence of miR-21 down-regulation on cell proliferation, apoptosis, invasion and migration of ovarian papillary adenocarcinoma cell lines (OVCAR3). Methods: Short-hairpin RNA (shRNA), specifically targeting miR-21, was constructed and transfected into OVCAR3 cells using the pSIREN-RetroQ linear vector (pSIREN-miR-21). The expression of miR-21 was detected with stem-loop real-time RT-PCR in OVCAR3 cells. Cell proliferation and apoptosis were monitored using the MTT assay and flow cytometry, respectively. Cell migration and invasion were assessed using the transwell migration and scratch-wound assay, respectively. Western-bloting was used for PDCD4 protein expression. Results: pSIREN-miR-21 suppress... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293645 Fri, 07 Oct 2011 22:45:02 +0100 5293645 http://www.medworm.com/index.php?rid=5293644&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968271%26dopt%3DAbstract Conclusion: These data support the central role of adiponectin and leptin in MetS, and demonstrated that adiponectin/leptin can be used as a highly sensitive and specific biomarker for MetS. PMID: 21968271 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293644 Fri, 07 Oct 2011 22:45:02 +0100 5293644 http://www.medworm.com/index.php?rid=5293643&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968272%26dopt%3DAbstract Conclusion: These results demonstrate that HMGB-1 levels in SF of knee OA patients are independently associated with radiographic disease severity. PMID: 21968272 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293643 Fri, 07 Oct 2011 22:45:02 +0100 5293643 http://www.medworm.com/index.php?rid=5293642&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21968273%26dopt%3DAbstract Conclusion: Time-dependent increases in circulating VPCs occur in critically ill patients with established AKI. Greater mobilization of VPCs may be associated with recovery of renal function, suggesting a potential role for VPCs in repair after kidney injury. PMID: 21968273 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5293642 Fri, 07 Oct 2011 22:45:02 +0100 5293642 http://www.medworm.com/index.php?rid=5138765&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810376%26dopt%3DAbstract Conclusion: Since the progam's inception, the number of CIP in Canada has grown. CIP are recognized as important mechanisms for integrating clinical and research training during residency to produce highly qualified clinician investigators. PMID: 21810376 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138765 Wed, 17 Aug 2011 23:30:15 +0100 5138765 http://www.medworm.com/index.php?rid=5138739&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810377%26dopt%3DAbstract Conclusions: Implants provided with pores of 20 and 25 µm achieved more than satisfactory bone-implant contact partial peaks. Further statistically significant experiments are needed in order to study, in depth, these surfaces. PMID: 21810377 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138739 Wed, 17 Aug 2011 23:30:15 +0100 5138739 http://www.medworm.com/index.php?rid=5138731&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810378%26dopt%3DAbstract Conclusions: Clopidogrel decreases hsCRP levels in patients with acute coronary syndrome. It might be desirable to lengthen the duration of the clopidogrel therapy to maintain its anti-inflammatory effects. PMID: 21810378 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138731 Wed, 17 Aug 2011 23:30:15 +0100 5138731 http://www.medworm.com/index.php?rid=5138714&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810379%26dopt%3DAbstract Conclusions: Demonstrated associations between investigator-level CRF and predictors suggest that CRF should be considered in the context of investigators' multiple roles. The study, without establishing causality, also documents evidence of multi-lateral returns to the enterprise of academic research from salary and trainee awards. The major limitation is that CRF and predictors are derived from a single funding agency. Findings should be viewed as preliminary and should serve to develop hypotheses for future, comprehensive research. PMID: 21810379 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138714 Wed, 17 Aug 2011 23:30:15 +0100 5138714 http://www.medworm.com/index.php?rid=5138703&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810380%26dopt%3DAbstract Conclusions: In conclusion, significantly increased CIMT and decreased PON1 activity suggest a relationship between atherosclerosis and AS: a relationship that is strongly correlated with disease duration. PMID: 21810380 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138703 Wed, 17 Aug 2011 23:30:15 +0100 5138703 http://www.medworm.com/index.php?rid=5138615&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810381%26dopt%3DAbstract Conclusions: Late-onset hypogonadism is associated with enhanced RANKL activity. Increased bone turnover-related OPG levels may act as a coupling factor between bone resorption and formation. The results suggest anti-RANKL-agents as therapeutic tools in osteoporotic men with late-onset hypogonadism. PMID: 21810381 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138615 Wed, 17 Aug 2011 23:30:15 +0100 5138615 http://www.medworm.com/index.php?rid=5138608&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810382%26dopt%3DAbstract Conclusions: Quantitation of plasma hTERT DNA by FQ-PCR may provide a novel complementary tool with potential clinical applications for the screening and detection of HCC. Plasma hTERT DNA has the potential to be a broad tumor marker for common cancers. PMID: 21810382 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138608 Wed, 17 Aug 2011 23:30:15 +0100 5138608 http://www.medworm.com/index.php?rid=5138594&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810383%26dopt%3DAbstract Conclusion: No association between depressive symptoms and NVP was observed; however, our sample size was very small and further studies could be done with a larger population of pregnant women. PMID: 21810383 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138594 Wed, 17 Aug 2011 23:30:15 +0100 5138594 http://www.medworm.com/index.php?rid=5138550&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810384%26dopt%3DAbstract Conclusion: Increased WBC count at admission was significantly and positively associated with in-hospital death or dependency at discharge among patients with acute cerebral infarction. PMID: 21810384 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138550 Wed, 17 Aug 2011 23:30:15 +0100 5138550 http://www.medworm.com/index.php?rid=5138542&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810385%26dopt%3DAbstract Conclusion: Administration of La1 had no effect on the immune system from the neonate to the adult in the normal mice. It did, however, significantly alter the percentages of IL-4 or IFN-γ expressing CD4+ T lymphocytes in the asthma model, suggesting that administration of La1 might regulate the immune response. PMID: 21810385 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=5138542 Wed, 17 Aug 2011 23:30:15 +0100 5138542 http://www.medworm.com/index.php?rid=4896488&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631986%26dopt%3DAbstract Authors: Hopps E, Valenti A, Caimi G Portopulmonary hypertension (PPHT) is a respiratory complication of portal hypertension, defined as an increase in mean pulmonary artery pressure (PAP) of > 25 mmHg with an increase in pulmonary vascular resistance of > 240 dyn.s/cm-5 and a normal pulmonary capillary wedge pressure ( < 15 mmHg), which often occurs in subjects with liver cirrhosis. Histopathological features of PPHT are endothelial and smooth-muscle cell proliferation and fibrosis leading to luminal obstruction in the resistance arteries. The pathogenesis of PPHT may result from an imbalance between vasoconstrictor and vasodilating factors. The most common pulmonary symptom is exertional dyspnea; fatigue, chest pain and syncope occur more often at an advanced stage. Edema, a... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896488 Sun, 05 Jun 2011 23:00:07 +0100 4896488 http://www.medworm.com/index.php?rid=4896487&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631987%26dopt%3DAbstract Conclusions: Rho/ROCK and TGF-β1/Smad3 signaling pathways have been shown to play a key role in intestinal fibrogenesis, which might provide with effective possibilities for clinical intervention. Understanding the cooperation between Smad3 and Rho, may therefore be critical to our overall understanding of fibrosis development and maintenance of CRE. PMID: 21631987 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896487 Sun, 05 Jun 2011 23:00:07 +0100 4896487 http://www.medworm.com/index.php?rid=4896486&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631988%26dopt%3DAbstract Conclusions: The adiponectin-BP relationship appears to be associated with premenopausal state. PMID: 21631988 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896486 Sun, 05 Jun 2011 23:00:07 +0100 4896486 http://www.medworm.com/index.php?rid=4896485&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631989%26dopt%3DAbstract Conclusion: Serum cortisol levels are significantly higher in men with metabolic syndrome. This effect is independent of waist circumference. PMID: 21631989 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896485 Sun, 05 Jun 2011 23:00:07 +0100 4896485 http://www.medworm.com/index.php?rid=4896484&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631990%26dopt%3DAbstract Conclusion: Crosstalk between HUVECs and HUASMCs occurred and was probably mediated by IL-8 in this 3-D co-culture model. PMID: 21631990 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896484 Sun, 05 Jun 2011 23:00:07 +0100 4896484 http://www.medworm.com/index.php?rid=4896483&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631991%26dopt%3DAbstract Conclusion: There is a high prevalence of vitamin D deficiency in pregnant women recruited in Saskatoon, Saskatchewan. Women with low circulating vitamin D concentrations are more likely to have hypertension. PMID: 21631991 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896483 Sun, 05 Jun 2011 23:00:07 +0100 4896483 http://www.medworm.com/index.php?rid=4896482&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631992%26dopt%3DAbstract Conclusion: Mgat5 is expressed at a relatively high level in CD133+ lung adenocarcinoma cells, and knockdown of Mgat5 in CD133+ cells inhibits cancer cell growth both in vitro and in vivo. These findings suggest Mgat5 may play an important role during oncogenesis, identifying a potential therapeutic target for pulmonary adenocarcinoma. PMID: 21631992 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896482 Sun, 05 Jun 2011 23:00:07 +0100 4896482 http://www.medworm.com/index.php?rid=4896481&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631993%26dopt%3DAbstract Conclusions: Increased formation of free radicals and oxidative stress, under conditions of hyperglycaemia, is one of the probable causes for evolution of complications in diabetes mellitus. Our study supports the hypothesis that oxidant/antioxidant balance is disturbed in diabetic patients. PMID: 21631993 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896481 Sun, 05 Jun 2011 23:00:07 +0100 4896481 http://www.medworm.com/index.php?rid=4896480&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631994%26dopt%3DAbstract Conclusions: Neointima formation and mesenteric fibrosis were the dominant pathological features. The increased expression of NPC1L1 might contribute to hypercholesterolemia, which may be involved in the pathogenesis of transplant arteriosclerosis. PMID: 21631994 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896480 Sun, 05 Jun 2011 23:00:07 +0100 4896480 http://www.medworm.com/index.php?rid=4896479&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631995%26dopt%3DAbstract Conclusion: TESE procedure does not cause ASA production in either males or their female partners. PMID: 21631995 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896479 Sun, 05 Jun 2011 23:00:07 +0100 4896479 http://www.medworm.com/index.php?rid=4896478&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631996%26dopt%3DAbstract Conclusion: The decrease of ΔΝp63α in cervical squamous cell cancer appears to be associated with the tumour progression, and ΔΝp63α may be a sensitive marker for cervical squamous cancer differentiation. PMID: 21631996 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4896478 Sun, 05 Jun 2011 23:00:07 +0100 4896478 http://www.medworm.com/index.php?rid=4688375&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21463544%26dopt%3DAbstract Authors: Berger M, Bosse D, Kuruvilla MS, Lang P, Murray JC, Nguyen LV In 2010, the annual general meeting of the Clinical Investigator Trainee Association of Canada - Association des cliniciens-chercheurs en formation du Canada (CITAC-ACCFC) and the Canadian Society for Clinician Investigators (CSCI) was held between September 20 and 22 in Ottawa. Several globally-renowned scientists, including this year's CSCI/Royal College Henry Friesen Award recipient, Dr. Paul Kubes, Distinguished Scientist Award recipient, Dr. Gideon Koren and Joe Doupe Young Investigator Award recipient, Dr. Torsten Neil, discussed a variety of topics relating to the role of technology in medicine. The meeting was well attended by clinician scientists and trainees from across Canada and offered trainees mentorsh... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4688375 Fri, 08 Apr 2011 20:45:07 +0100 4688375 http://www.medworm.com/index.php?rid=4688364&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21463545%26dopt%3DAbstract Conclusion: These findings provide good evidence that minocycline can reduce the renal dysfunction and injury caused by I/R of the kidney. Its mechanism may involve suppression of apoptosis, inflammatory response and oxidative stress. PMID: 21463545 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4688364 Fri, 08 Apr 2011 20:45:07 +0100 4688364 http://www.medworm.com/index.php?rid=4688363&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21463546%26dopt%3DAbstract Conclusion: These results suggest that the influence of obesity on lung function in healthy subjects is mostly mediated by mechanical factors. Furthermore, not only BMI but also the pattern of fat distribution should be considered when studying associations between adiposity indices and mechanical or inflammatory variables potentially associated with pulmonary function. PMID: 21463546 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4688363 Fri, 08 Apr 2011 20:45:07 +0100 4688363 http://www.medworm.com/index.php?rid=4688359&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21463547%26dopt%3DAbstract Conclusion: N-glycan-defective MA782 cells can induce the differentiation of BMDM into proinflammatory M1 macrophages in vitro. PMID: 21463547 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4688359 Fri, 08 Apr 2011 20:45:07 +0100 4688359 http://www.medworm.com/index.php?rid=4688353&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21463548%26dopt%3DAbstract Conclusion: These results suggest that radial artery and superior vena cava blood collection sites are comparable and may be used clinically with respect to fasting glucose, NEFA, leptin, adiponectin, total ghrelin, hs-CRP and NT-proBNP concentrations in a group of severely obese patients. PMID: 21463548 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4688353 Fri, 08 Apr 2011 20:45:07 +0100 4688353 http://www.medworm.com/index.php?rid=4688352&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21463549%26dopt%3DAbstract Conclusion: Our data suggest that serum SFRP2 methylation status represents a promising, non-invasive marker for CRC detection and staging. Hypermethylated SFRP2 may have prognostic relevance in patients with CRC. PMID: 21463549 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4688352 Fri, 08 Apr 2011 20:45:07 +0100 4688352 http://www.medworm.com/index.php?rid=4688351&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21463550%26dopt%3DAbstract Conclusions: In elderly patients who were hospitalized for acute medical illness, elevated D-dimer levels are associated with subsequent VTE events. Our data suggest that measurement of D-dimer, a widely-performed objective test, may help clinicians address high-risk individuals for VTE. PMID: 21463550 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4688351 Fri, 08 Apr 2011 20:45:07 +0100 4688351 http://www.medworm.com/index.php?rid=4458336&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21291630%26dopt%3DAbstract Conclusion: The overexpression of FOXM1 protein in cervical cancer maybe associated with the progression of cervical cancer, and could be a potentially novel tumor marker useful for diagnosis and therapy of cervical cancer. PMID: 21291630 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4458336 Thu, 10 Feb 2011 21:30:03 +0100 4458336 http://www.medworm.com/index.php?rid=4458335&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21291631%26dopt%3DAbstract Conclusion: Serum Lp(a) was higher in the UAP and MI patients in comparison with the SAP patients, and was higher in 3-vessel CAD in comparison with 1- and 2-vessel CAD patients. PMID: 21291631 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4458335 Thu, 10 Feb 2011 21:30:03 +0100 4458335 http://www.medworm.com/index.php?rid=4458334&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21291632%26dopt%3DAbstract Conclusion: This study showed that a great majority of parents of children in this population used CAM modalities and that herbal products were preferred. Most parents did not inform their physicians of their use of CAM. In the light of these findings, pediatricians should be prepared to discuss alternative therapies with parents, since talking about CAM may be helpful in minimizing associated risks. PMID: 21291632 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4458334 Thu, 10 Feb 2011 21:30:03 +0100 4458334 http://www.medworm.com/index.php?rid=4458333&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21291633%26dopt%3DAbstract Conclusions: Hepatic pathologic lesions, particularly cirrhosis, may contribute to the elevation of NT-proBNP in subjects with HBV/HCV infection. PMID: 21291633 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4458333 Thu, 10 Feb 2011 21:30:03 +0100 4458333 http://www.medworm.com/index.php?rid=4458332&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21291634%26dopt%3DAbstract Conclusion: Bacteremia induced by pandrug-resistant isolates is accompanied by less damage compared with bacteremia by drug-susceptible isolates. Rabbits infected with a pandrug-resistant isolate of K. pneumoniae survived longer and had a lower inflammatory response than did animals infected with drug-susceptible isolates. PMID: 21291634 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4458332 Thu, 10 Feb 2011 21:30:03 +0100 4458332 http://www.medworm.com/index.php?rid=4458331&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21291635%26dopt%3DAbstract Conclusion: Our results suggest that LYVE-1 allows the adhesion of tumor cells through the interaction of HA on the tumor cell membrane with LYVE-1. PMID: 21291635 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4458331 Thu, 10 Feb 2011 21:30:03 +0100 4458331 http://www.medworm.com/index.php?rid=4458330&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21291636%26dopt%3DAbstract Conclusion: Chemotherapy with 5-FU by continuous intravenous infusion in combination with split-dose cisplatin is effective with a tolerable toxicity profile in patients with recurrent, or metastatic squamous-cell carcinoma of head and neck. The overall response was significantly higher in patients undergoing initial treatment in comparison with patients undergoing re-treatment after relapse. PMID: 21291636 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4458330 Thu, 10 Feb 2011 21:30:03 +0100 4458330 http://www.medworm.com/index.php?rid=4245855&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134335%26dopt%3DAbstract Authors: Nielsen TO Clinician-scientists have the training and motivation to translate basic science into tools for improved clinical care, but the road to achieve this is hardly straight forward, particularly for large scale genomic datasets. This year's Joe Doupe Young Investigator award winner, Dr. Torsten Nielsen, details successful examples of new scientific insights, diagnostics and clinical trials that have resulted from microarray-based gene expression profiling of sarcomas: TLE1 as a biomarker for synovial sarcoma, histone deacetylase inhibitor therapy for translocation-associated sarcomas of young adults, and CSF1 pathway inhibitors for tenosynovial giant cell tumors. Results from exciting, emerging next generation sequencing technologies will need to undergo similar validati... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245855 Fri, 10 Dec 2010 10:20:04 +0100 4245855 http://www.medworm.com/index.php?rid=4245854&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134336%26dopt%3DAbstract Authors: Koren G, Nickel S Every year scores of new pharmaceuticals enter the market, almost never with human fetal safety data. Such data typically accumulate during the first years of clinical use, in the form of case reports, case series, prospective and retrospective cohorts and case control studies. All of these methods suffer from serious sources of bias, often leading to alarming signals of teratogenicity that are later found to be false. This review highlights major sources of bias, including the bias against the null hypothesis in its different forms, ascertainment and recall bias, in fetal exposure to pharmaceutical molecules. PMID: 21134336 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245854 Fri, 10 Dec 2010 10:20:04 +0100 4245854 http://www.medworm.com/index.php?rid=4245853&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134337%26dopt%3DAbstract Authors: Burns KD, Wolfs W, Bélanger P, McLaughlin K, Levin A Background: The prevalence of kidney disease is rising in Canada, and new approaches to prevention, diagnosis, and treatment are required. A kidney research training strategy, which enhances capacity while fostering collaboration and knowledge translation, may help to address this health care problem. Purpose: This manuscript describes the Kidney Research Scientist Core Education and National Training (KRESCENT) Program that was launched in 2004 with a major goal to enhance kidney research capacity in Canada. Features: KRESCENT is an innovative training program, which recruits from a variety of research disciplines, and emphasizes multi-disciplinary research approaches, team-based collaboration and knowledge translation. Th... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245853 Fri, 10 Dec 2010 10:20:04 +0100 4245853 http://www.medworm.com/index.php?rid=4245852&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134338%26dopt%3DAbstract Conclusion In osteoporosis spine surgery, excellent bone-screw interface and fixation strength can be achieved by using MEPS. MEPS are a novel approach to increase the pedicle screw fixation in osteoporotic and revision spine surgeries. PMID: 21134338 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245852 Fri, 10 Dec 2010 10:20:04 +0100 4245852 http://www.medworm.com/index.php?rid=4245851&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134339%26dopt%3DAbstract Conclusion: This national survey demonstrates that perioperative ASA usage as reported by surgeons is variable, identifying the need for, and community interest in, a large perioperative ASA trial. PMID: 21134339 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245851 Fri, 10 Dec 2010 10:20:04 +0100 4245851 http://www.medworm.com/index.php?rid=4245850&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134340%26dopt%3DAbstract Conclusion: The association between reduced serum AAT concentration and HIV infection is consistent with a role for AAT as an endogenous HIV suppressor. PMID: 21134340 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245850 Fri, 10 Dec 2010 10:20:04 +0100 4245850 http://www.medworm.com/index.php?rid=4245849&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134341%26dopt%3DAbstract Conclusions: Elevated rates of ESRD experienced by FN with diabetes are related to poorer glycemic control at all levels of renal function, and lower age-related mortality at advanced stages of chronic kidney disease. PMID: 21134341 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245849 Fri, 10 Dec 2010 10:20:04 +0100 4245849 http://www.medworm.com/index.php?rid=4245848&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134342%26dopt%3DAbstract Conclusions: High sLOX-1 levels are associated with the presence and severity of CAD in patients with MetS. The measurement of serum sLOX-1may be potentially useful in predicting the presence and severity of CAD in patients with MetS. PMID: 21134342 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245848 Fri, 10 Dec 2010 10:20:04 +0100 4245848 http://www.medworm.com/index.php?rid=4245847&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134343%26dopt%3DAbstract Conclusion: Our data support the hypothesis that FTO rs9939609 polymorphism is strongly associated with obesity and CRP levels in the Chinese population as reported in the European population. PMID: 21134343 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245847 Fri, 10 Dec 2010 10:20:04 +0100 4245847 http://www.medworm.com/index.php?rid=4245846&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134344%26dopt%3DAbstract Conclusion: In conclusion, montelukast was effective on burn wound healing. Moreover, the effect was amplified when combined with topical antibiotics applied in the early stage of burn wound healing. PMID: 21134344 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245846 Fri, 10 Dec 2010 10:20:04 +0100 4245846 http://www.medworm.com/index.php?rid=4245845&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21134345%26dopt%3DAbstract Conclusion: Our data reveal a marked elevation of peripheral blood CD4+CD25+Foxp3+ Tregs during early pregnancy, but a dramatic decline during labor, either at term or preterm, suggesting their involvement in the maintenance of pregnancy and the initiation of labor. PMID: 21134345 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4245845 Fri, 10 Dec 2010 10:20:04 +0100 4245845 http://www.medworm.com/index.php?rid=4060325&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926032%26dopt%3DAbstract Authors: Qu HQ, Tien M, Polychronakos C Clinical & Investigative Medicine (CIM) is receiving an increasing number of reports of candidate-based association studies. The track record of such studies in the past has been poor: numerous genetic associations reported from candidate gene studies have not been replicated in later studies. The rise of the genome-wide association study (GWAS) is changing this situation. A well-designed GWAS may identify a number of candidate loci without bias by screening the whole human genome. Validating and fine-mapping the candidate loci from GWAS are required to clarify the genetic mechanisms. Thus, a candidate-based association study has become a well-directed effort, instead of searching for a needle in a haystack. In the post-GWAS era, exponential ... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060325 Wed, 13 Oct 2010 02:30:18 +0100 4060325 http://www.medworm.com/index.php?rid=4060322&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926033%26dopt%3DAbstract Conclusion: These results indicate hypergammablobulinemia and lower MVC in hyperythyroid patients, and higher IgE levels, C3 levels and eosinophil count as well as anemia in hypothyroid patients. PMID: 20926033 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060322 Wed, 13 Oct 2010 02:30:18 +0100 4060322 http://www.medworm.com/index.php?rid=4060319&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926034%26dopt%3DAbstract Conclusion: Taken together, our results suggest that γδ-T cells, combined with galectin-1 antibody treatment, could be a more effective adoptive immunotherapy for patients with cervical cancer than traditional adoptive immunotherapy methods. PMID: 20926034 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060319 Wed, 13 Oct 2010 02:30:18 +0100 4060319 http://www.medworm.com/index.php?rid=4060317&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926035%26dopt%3DAbstract Conclusion: MTHFR C677T gene polymorphism may contribute to insulin resistance in Han Chinese with MS by increasing hs-CRP and decreasing vitamin B12, and consequently play an important role in development of MS-associated T2DM. PMID: 20926035 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060317 Wed, 13 Oct 2010 02:30:18 +0100 4060317 http://www.medworm.com/index.php?rid=4060314&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926036%26dopt%3DAbstract Conclusions: JAD can be divided into two types based on location of the papillae. ERCP was the primary method of diagnosing JAD and patients with severe complications required surgical intervention. PMID: 20926036 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060314 Wed, 13 Oct 2010 02:30:18 +0100 4060314 http://www.medworm.com/index.php?rid=4060312&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926037%26dopt%3DAbstract Conclusion: Insufficient myocardial reperfusion was a strong independent predictor of LV remodeling and functional recovery in AMI patients with TIMI flow grade 3 and CTFC < 40 after recanalization. MCE has important additional value for prognosis and risk assessment in patients with acute myocardial infarction following recanalization. PMID: 20926037 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060312 Wed, 13 Oct 2010 02:30:18 +0100 4060312 http://www.medworm.com/index.php?rid=4060308&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926038%26dopt%3DAbstract Conclusions: This study clearly demonstrates increased anti-oxidant capacity and decreased oxidative stress with statin use. Atorvastatin use may also increase Cp levels although this effect appears to be independent of its anti-oxidant effects. PMID: 20926038 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060308 Wed, 13 Oct 2010 02:30:18 +0100 4060308 http://www.medworm.com/index.php?rid=4060306&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926039%26dopt%3DAbstract Conclusion: Given a sufficient chemical stimulus, obese subjects will attempt to breathe more, although this does not mean more VA, which removes CO2. PMID: 20926039 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060306 Wed, 13 Oct 2010 02:30:18 +0100 4060306 http://www.medworm.com/index.php?rid=4060303&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20926040%26dopt%3DAbstract Conclusion: The increase in TOS following conventional phototherapy was not not observed following LED phototherapy. This difference should be considered when using phototherapy. PMID: 20926040 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=4060303 Wed, 13 Oct 2010 02:30:18 +0100 4060303 http://www.medworm.com/index.php?rid=3849837&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20691139%26dopt%3DAbstract Authors: Hartwick M, Jones G Clinical medicine tries to resolve the uncertainties of diagnosis and prognosis. The natural history of the illness is repeatedly examined using both our own knowledge base and that of our colleagues. This is an iterative hypothesis testing process that starts with the history and physical examination and progresses with increasingly complex tests. Thus, the uncertainty of diagnosis and prognosis is diminished but never absolutely eliminated because of the limits of both our knowledge and our tests. Our scientific hypothesis testing, using the reductionist process, by which the whole can be deduced from the sum of its parts, has some human limitations. Science deals with generalities that strive to be objective and value free. In contradistinction, the pati... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3849837 Wed, 11 Aug 2010 04:30:03 +0100 3849837 http://www.medworm.com/index.php?rid=3849836&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20691140%26dopt%3DAbstract Conclusion: The quest to identify miRNA genes that are of biological significance in medulloblastomas is on an ongoing venture. Most importantly, these miRNAs have been shown to be of clinical importance for improving the accuracy of diagnosis and prognosis and even developing therapies that can significantly improve patients' overall survival from this deadly disease. PMID: 20691140 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3849836 Wed, 11 Aug 2010 04:30:03 +0100 3849836 http://www.medworm.com/index.php?rid=3849835&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20691141%26dopt%3DAbstract Authors: Tomaiuolo AC, Alghisi F, Petrocchi S, Surace C, Roberti MC, Bella S, Lucidi V, Angioni A Since the identification of the Cystic Fibrosis transmembrane conductance regulator (CFTR) gene in 1989, many genetic mutations have been found in cystic fibrosis (CF) patients. Dysfunctions of the CFTR gene are responsible for the highly variable clinical presentation ranging from severe CF, disseminated bronchiectasis, idiopathic chronic pancreatitis and congenital bilateral absence of vas deferens (CBAVD). Linkage disequilibrium studies have shown that some mutations are stringently coupled with polymorphisms in a genetic complex called haplotype. From a familial study of a patient with CBAVD, carrier of the A1006E mutation, we have observed its strict association with the polymorphism ... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3849835 Wed, 11 Aug 2010 04:30:03 +0100 3849835 http://www.medworm.com/index.php?rid=3849834&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20691142%26dopt%3DAbstract Conclusion: Knowledge of underlying ethical principles, understanding of professional duties, and adoption of a process for mediation and conflict resolution are essential to ensuring that physicians and institutions act responsibly in maintaining a patients' best interests in the context of family-centred care. PMID: 20691142 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3849834 Wed, 11 Aug 2010 04:30:03 +0100 3849834 http://www.medworm.com/index.php?rid=3849833&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20691143%26dopt%3DAbstract Conclusion: O-CMC appears to be effective in the prevention of postoperative peritoneal adhesion formation, which may be attributed to decreased accumulation of inflammatory cells and fibroblasts and reduced collagen synthesis. PMID: 20691143 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3849833 Wed, 11 Aug 2010 04:30:03 +0100 3849833 http://www.medworm.com/index.php?rid=3849832&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20691144%26dopt%3DAbstract Conclusion: We found no adverse effects of LLT on physical functioning or quality of life. Indeed, men treated with LLT had significantly better SF-36 PF scores than men treated non-pharmacologically. PMID: 20691144 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3849832 Wed, 11 Aug 2010 04:30:03 +0100 3849832 http://www.medworm.com/index.php?rid=3633020&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519092%26dopt%3DAbstract In conclusion, our data show for the first time that diabetes alters both the gene and protein expression of ClC-3 channels. These changes may contribute to the impaired vascular, brain and kidney functions observed in diabetes. PMID: 20519092 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633020 Sun, 06 Jun 2010 13:30:03 +0100 3633020 http://www.medworm.com/index.php?rid=3633019&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519093%26dopt%3DAbstract Conclusion: Although some serum trace element levels in our patients were higher or lower than normal values, the mean values were within normal limits. Thus, we were unable to detect a relationship between serum trace element levels and AN-. In the future, larger studies should be conducted to confirm these findings. PMID: 20519093 [PubMed - as supplied by publisher] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633019 Sun, 06 Jun 2010 13:30:03 +0100 3633019 http://www.medworm.com/index.php?rid=3633018&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519094%26dopt%3DAbstract Conclusion: Platelet volume, and therefore platelet activation, appears to play a causal role in late SVG disease graft disease; hence, MPV may be useful as a post-operative marker of graft success. PMID: 20519094 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633018 Sun, 06 Jun 2010 13:30:03 +0100 3633018 http://www.medworm.com/index.php?rid=3633017&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519095%26dopt%3DAbstract Conclusion: FK506 treatment (1.0 mg/kg/day, intramuscularly administrated to recipients on POD0-13, 20 and 27) can be used effectively to establish a rat OBST model of CR that will be useful for the study of the pathogenesis of CR and the effectiveness of various drugs. PMID: 20519095 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633017 Sun, 06 Jun 2010 13:30:03 +0100 3633017 http://www.medworm.com/index.php?rid=3633016&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519096%26dopt%3DAbstract Conclusion: A combination of G-CSF stimulation and autologous transplantation of bone marrow stem cells synergistically improved neovascularization and angiogenesis in ischemic limb tissues in diabetic rabbits. PMID: 20519096 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633016 Sun, 06 Jun 2010 13:30:03 +0100 3633016 http://www.medworm.com/index.php?rid=3633015&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519097%26dopt%3DAbstract Conclusion: GR-beta mRNA was highly expressed in patients with nasal polyps. Down- regulation of GR-alpha mRNA suggests the existence of glucocorticoid insensitivity. Expression of GR-beta may plays an important role in the evaluation of the glucocorticoid therapeutic effect in patients with nasal polyps. PMID: 20519097 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633015 Sun, 06 Jun 2010 13:30:03 +0100 3633015 http://www.medworm.com/index.php?rid=3633014&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519098%26dopt%3DAbstract Conclusion: Low dose prednisolone and colchicine were both effective in treating RAS. Given that the two therapies had similar efficacy, yet colchicine was associated with more side effects, , 5mg/d of prednisolone seems to be a better alternative in reducing the signs and symptoms of the disease. PMID: 20519098 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633014 Sun, 06 Jun 2010 13:30:03 +0100 3633014 http://www.medworm.com/index.php?rid=3633013&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519099%26dopt%3DAbstract Conclusion. Our data indicate that the combined vaccination with BCG and IL-12 yields a favorable outcome in prevention of experimental allergic airway inflammation, which is likely mediated through triggering a shift from a Th2 response to a Th1 response. PMID: 20519099 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633013 Sun, 06 Jun 2010 13:30:03 +0100 3633013 http://www.medworm.com/index.php?rid=3633012&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519100%26dopt%3DAbstract Conclusion: Our data suggest that adding the simple calculation of alpha-ratio improves the ability of detecting gonadotropin alpha-subunit hypersecretion and thereby indentifying patients with NFPAs. PMID: 20519100 [PubMed - as supplied by publisher] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633012 Sun, 06 Jun 2010 13:30:03 +0100 3633012 http://www.medworm.com/index.php?rid=3633011&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20519101%26dopt%3DAbstract Authors: Duthie K, Riddell M, Weller C, Coltan LI, Benzies K, Olson DM Strategic prioritization of research agendas to address health problems with a large social and economic burden has increased the demand for interdisciplinary research. Universities have addressed the need for interdisciplinary research in their strategic documents. However, research training to equip graduates for careers in interdisciplinary research teams has not kept pace. We offer recommendations to graduate students, universities, health services organizations, and health research funders designed to increase the capacity for interdisciplinary research team training, and provide an example of an existing training program. PMID: 20519101 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3633011 Sun, 06 Jun 2010 13:30:03 +0100 3633011 http://www.medworm.com/index.php?rid=3449283&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370990%26dopt%3DAbstract Conclusions: Both AOPP and IMA may be helpful clinical markers for estimating kidney dysfunction, but AOPP is better able to identify diabetic patients with nephropathy. We suggest that AOPP is almost ideal for discriminating between T2DM patients with micro- and macroalbuminuria. PMID: 20370990 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449283 Thu, 08 Apr 2010 17:56:03 +0100 3449283 http://www.medworm.com/index.php?rid=3449282&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370991%26dopt%3DAbstract Conclusion: Early enteral nutrition with dietary fiber could alleviate damage to intestinal barrier function and decreased the incidence of bacterial translocation caused by trauma and endotoxemia in rats under extra-abdominal trauma. PMID: 20370991 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449282 Thu, 08 Apr 2010 17:56:03 +0100 3449282 http://www.medworm.com/index.php?rid=3449281&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370992%26dopt%3DAbstract Conclusion: There is potential utility of screening for lung cancer with miRNA expression profiles. Future work will focus on the sensitivity of such miRNA expression profiles in screening sputum for lung cancer, which can be performed in real time. PMID: 20370992 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449281 Thu, 08 Apr 2010 17:56:03 +0100 3449281 http://www.medworm.com/index.php?rid=3449280&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370993%26dopt%3DAbstract This article provides a personalized overview of the role of proteinases in generating hormone-like cell signals. Also outlined is the unexpected route of discovery that led one investigator over a four-decade time span, from early studies of the interactions of oxytocin and vasopressin with their neurophysin binding proteins to current studies of the tethered ligand activation mechanism that is unique for the G-protein-coupled family of proteinase-activated receptors (PARs). The focus is not only on the intriguing PAR receptor family, but also on alternative mechanisms whereby proteinases activate signal transduction pathways. Also summarized are the potential physiological and pathophysiological roles that PARs may play in the setting of inflammatory disorders ranging from arthritis to c... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449280 Thu, 08 Apr 2010 17:56:03 +0100 3449280 http://www.medworm.com/index.php?rid=3449279&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370994%26dopt%3DAbstract Conclusions: These results suggest that government regulations do not discriminate against teaching facilities. Surgical residents in states with such regulation gain similar or superior exposure to procedures as residents in states without such laws. PMID: 20370994 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449279 Thu, 08 Apr 2010 17:56:03 +0100 3449279 http://www.medworm.com/index.php?rid=3449278&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370995%26dopt%3DAbstract Conclusion: Our data suggest that TNF-alpha (-308) may be associated with the development of generalized aggressive periodontitis. These results should be replicated in a larger and more diverse population of patients diagnosed with generalized aggressive periodontitis to determine of these findings are generalizable. PMID: 20370995 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449278 Thu, 08 Apr 2010 17:56:03 +0100 3449278 http://www.medworm.com/index.php?rid=3449277&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370996%26dopt%3DAbstract Conclusions: Differences were seen for PEF between genders and between types of school, and a linear correlation was seen for PEF with both age and height in healthy children from five to ten years old. PMID: 20370996 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449277 Thu, 08 Apr 2010 17:56:03 +0100 3449277 http://www.medworm.com/index.php?rid=3449276&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20370997%26dopt%3DAbstract Conclusion: The high frequency of low quality of care underlines the necessity for orthopedic surgeons to be involved in primary care education. Identifying factors associated with lower quality of care will orient efforts to improve medical care of patients with isolated traumatic injury. PMID: 20370997 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3449276 Thu, 08 Apr 2010 17:56:03 +0100 3449276 http://www.medworm.com/index.php?rid=3260999&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144263%26dopt%3DAbstract Authors: Dugani S, Ong Tone S The Clinician Investigator Trainee Association of Canada - Association des cliniciens-chercheurs en formation du Canada (CITAC-ACCFC) is a national organization composed of MD+ trainees enrolled in MD/MSc, MD/PhD, and Clinician Investigator Programs (CIP) across Canada. In less than three years since its conception, CITAC-ACCFC has become an established organization with over 200 members from fifteen academic institutions. The mission of the CITAC-ACCFC is to organize and promote activities that support clinician investigator trainees in Canada, with the intention to improve academic and post-graduate career opportunities, expand institutional and public awareness of clinician investigator programs, and develop a nationally accessible information database ... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260999 Thu, 11 Feb 2010 15:04:03 +0100 3260999 http://www.medworm.com/index.php?rid=3260998&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144264%26dopt%3DAbstract Conclusions: The TGFBR2 gene missense mutations are possibly causative mutations of Loeys-Dietz syndrome. This result suggests an increase in the mutation spectrum of Marfan-related disorders in China and possibly world-wide. PMID: 20144264 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260998 Thu, 11 Feb 2010 15:04:03 +0100 3260998 http://www.medworm.com/index.php?rid=3260997&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144265%26dopt%3DAbstract Conclusion: We investigated COX-2 expression at the level of its protein as well as its messenger RNA in a series of recurrent colorectal cancers. These observations give additional information about the possibility that COX-2 could be involved in tumor promotion during colorectal cancer progression. PMID: 20144265 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260997 Thu, 11 Feb 2010 15:04:03 +0100 3260997 http://www.medworm.com/index.php?rid=3260996&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144266%26dopt%3DAbstract La création d'une Section étudiante dans le CIM. Clin Invest Med. 2010;33(1):E3 Authors: Dugani S, Ong Tone S L'Association des cliniciens-chercheurs en formation du Canada - the Clinician Investigator Trainee Association of Canada (ACCFC-CITAC) est une organisation nationale composée de MD+ en formation, inscrits dans un programme MD/MSc, MD/PhD ou clinicien-chercheur (PCC) à travers le Canada. Depuis sa création il y a moins de trois ans, l'ACCFC-CITAC est devenue une organisation bien établie comptant plus de 200 membres appartenant à quinze institutions académiques. La mission de l'ACCFC-CITAC est d'organiser et de promouvoir des activités qui soutiennent les cliniciens-chercheurs en formation au Canada, dans l'intention d'am&#xE... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260996 Thu, 11 Feb 2010 15:04:03 +0100 3260996 http://www.medworm.com/index.php?rid=3260995&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144267%26dopt%3DAbstract Conclusion: In the majority of the group of mothers with language delayed children and even mothers of children with normal language development, there were high levels concern. Mothers' concerns and anxiety levels may decrease with increasing levels of their education levels. We recommend providing detailed information regarding language development to the families at all stages of the childs' training programme. PMID: 20144267 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260995 Thu, 11 Feb 2010 15:04:03 +0100 3260995 http://www.medworm.com/index.php?rid=3260994&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144268%26dopt%3DAbstract Conclusion: There appears to be a relationship between CIMT, FMD and severity of coronary atherosclerosis in patients with ACS. However, in patients with ACS, morphologic properties of stenotic lesions are not associated with CIMT and FMD in brachial artery. PMID: 20144268 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260994 Thu, 11 Feb 2010 15:04:03 +0100 3260994 http://www.medworm.com/index.php?rid=3260993&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144269%26dopt%3DAbstract Conclusion: Gal-3 is expressed at a relatively higher level in CD133+ lung adenocarcinoma cells and could induce CD8+ T cell apoptosis in vitro, both of which could be down-regulated by Gal-3 siRNA. These findings indicate that Gal-3 may play an important role during oncogenesis, implying a potential therapeutic target for pulmonary adenocarcinoma. PMID: 20144269 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260993 Thu, 11 Feb 2010 15:04:03 +0100 3260993 http://www.medworm.com/index.php?rid=3260992&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144270%26dopt%3DAbstract Conclusion: LPS induced IgA1 aberrant O-glycosylation and suppressed C1GALT1C1 expression in patients with IgAN. Upregulation of C1GALT1C1 expression by 5-AZA could reverse the IgA1 aberrant O-glycosylation. These results suggest that C1GALT1C1 may play a key role in the regulation of IgA1 O-glycosylation. PMID: 20144270 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260992 Thu, 11 Feb 2010 15:04:03 +0100 3260992 http://www.medworm.com/index.php?rid=3260991&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144271%26dopt%3DAbstract Conclusions: Single blood pressure readings, taken with oscillometric monitors in subjects with atrial fibrillation differ, often markedly, from those taken manually. Health care professionals should record multiple readings manually, using validated instruments when making therapeutic decisions. PMID: 20144271 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260991 Thu, 11 Feb 2010 15:04:03 +0100 3260991 http://www.medworm.com/index.php?rid=3260990&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144272%26dopt%3DAbstract Conclusion: The results support a role for an asporin D repeat polymorphism in the susceptibility to AS and an influence of this gene on the outcome of the disease. D14 and D16 allele variants of ASPN might be the susceptibility alleles for AS in the Han Chinese population, whereas the D13 allele variant may have a protective effect on the onset of AS. PMID: 20144272 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260990 Thu, 11 Feb 2010 15:04:03 +0100 3260990 http://www.medworm.com/index.php?rid=3260989&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144273%26dopt%3DAbstract Authors: Ong Tone S, Dugani S, Marshall H, Shamji MF, Murray JC, Bossé D From September 21st-23rd 2009, the Clinical Investigator Trainee Association of Canada - Association des cliniciens-chercheurs en formation du Canada (CITAC-ACCFC) and the Canadian Society for Clinician Investigators (CSCI), held their annual conference in Ottawa. Participants included clinician investigators and trainees from across the country. The conference featured many excellent guest speakers including this year's recipient of the Henry G. Friesen International Prize in Health Research, Sir John Bell. There were several forums focusing on professional development, with topics such as "sustaining the clinician investigator in Canada", "succeeding as a clinician investigator", and "collaborating internat... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260989 Thu, 11 Feb 2010 15:04:03 +0100 3260989 http://www.medworm.com/index.php?rid=3260987&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144274%26dopt%3DAbstract Survol du programme scientifique du congrès annuel de la SCRC-ACCFC 2009. Clin Invest Med. 2010;33(1):E73 Authors: Ong Tone S, Dugani S, Marshall H, Shamji MF, Murray JC, Bossé D Du 21 au 23 septembre 2009 a eu lieu à Ottawa le congrès annuel de l'Association des cliniciens-chercheurs en formation du Canada - Clinical Investigator Trainee Association of Canada (ACCFC-CITAC) et de la Société canadienne de recherche clinique (SCRC). Parmi les participants se trouvaient des cliniciens-chercheurs et des étudiants en provenance des quatre coins du pays. Cette conférence mettait à l'avant-plan des invités de marque, dont le récipiendaire actuel du Prix international de la recherche en santé Henry G. Friesen, Sir John Bell. P... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3260987 Thu, 11 Feb 2010 15:04:03 +0100 3260987 http://www.medworm.com/index.php?rid=3104603&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003825%26dopt%3DAbstract Authors: Gan BS PMID: 20003825 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104603 Sat, 19 Dec 2009 15:54:03 +0100 3104603 http://www.medworm.com/index.php?rid=3104602&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003826%26dopt%3DAbstract CONCLUSION: Lentivirus-mediated siRNA therapy inhibits the growth of human lung cancer cells in vitro. The siRNA therapy also suppresses the growth of the transplanted lung cancer in mice. PMID: 20003826 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104602 Sat, 19 Dec 2009 15:54:03 +0100 3104602 http://www.medworm.com/index.php?rid=3104601&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003827%26dopt%3DAbstract CONCLUSION: MIC values of parenteral preparations were higher than their blood levels in clinical use. Thus, effects of parenteral preparations may not have been reflected in routine clinical practice. However, topical forms have antibacterial activity due to additive substrates and the use of high concentration levels at the site of application. Therefore, in selection of topical forms for appropriate cases, these effects should also be taken into consideration. The antibacterial activity of topical antihistaminic preparations may be useful in certain dermatological pathology. PMID: 20003827 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104601 Sat, 19 Dec 2009 15:54:03 +0100 3104601 http://www.medworm.com/index.php?rid=3104600&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003828%26dopt%3DAbstract CONCLUSIONS: The study demonstrated that atorvastatin can improve arterial stiffness in CAD patients independent of its lipid-lowering properties. PMID: 20003828 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104600 Sat, 19 Dec 2009 15:54:03 +0100 3104600 http://www.medworm.com/index.php?rid=3104599&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003829%26dopt%3DAbstract CONCLUSION: These results indicate that there may be a link with higher Hb values and cardiovascular risk factors in patients with IGT. Further investigation is warranted to understand the clinical implications of these findings in subjects with prediabetes. PMID: 20003829 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104599 Sat, 19 Dec 2009 15:54:03 +0100 3104599 http://www.medworm.com/index.php?rid=3104598&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003830%26dopt%3DAbstract CONCLUSIONS: There was alteration in baroreflex sensitivity among rats of the same strain. Care should be taken when interpreting studies employing WKY as a control for the SHR. PMID: 20003830 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104598 Sat, 19 Dec 2009 15:54:03 +0100 3104598 http://www.medworm.com/index.php?rid=3104597&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003831%26dopt%3DAbstract CONCLUSIONS: Determination of DD3(PCA3)gene expression by RT-PCR could be a potentially tool for the early detection of PCa in clinical specimens. PMID: 20003831 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104597 Sat, 19 Dec 2009 15:54:03 +0100 3104597 http://www.medworm.com/index.php?rid=3104596&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003832%26dopt%3DAbstract CONCLUSION: Our findings provide support for the long-term safety and efficacy of the GH receptor antagonist pegvisomant in achieving IGF-I control in patients with refractory acromegaly. PMID: 20003832 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104596 Sat, 19 Dec 2009 15:54:03 +0100 3104596 http://www.medworm.com/index.php?rid=3104595&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003833%26dopt%3DAbstract CONCLUSION: Our results demonstrated that beta-tubulin III mRNA expression level in malignant effusions, in which all cancer cells were metastatic, was correlated with docetaxel sensitivity in NSCLC. This highlights the potential role of biomarkers in malignant effusions in further customized chemotherapy. PMID: 20003833 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104595 Sat, 19 Dec 2009 15:54:03 +0100 3104595 http://www.medworm.com/index.php?rid=3104593&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003834%26dopt%3DAbstract CONCLUSION: This prospective study showed that fibrinolytic markers such as PAI-1, tPA, tPA/PAI-1 complex are independently associated with the development of hypertension. This supports the hypothesis that disturbances in fibrinolysis precede a cardiovascular event. Therefore, hypertension may be associated with impaired fibrinolysis. PMID: 20003834 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104593 Sat, 19 Dec 2009 15:54:03 +0100 3104593 http://www.medworm.com/index.php?rid=3104591&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003835%26dopt%3DAbstract CONCLUSION: AVP secretion in response to acute hypo- and hyperosmolality is not different in normal weight and obese subjects. There is no correlation between leptin and AVP in normal weight or obese subjects. PMID: 20003835 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104591 Sat, 19 Dec 2009 15:54:03 +0100 3104591 http://www.medworm.com/index.php?rid=3104589&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003836%26dopt%3DAbstract CONCLUSIONS: Children with mild pulmonary impairments are able to achieve a near normal peak power output and a normal VO2peak. Neither the aetiology nor the developmental onset of the process appears to be important influences on VO2peak or Wpeak. PMID: 20003836 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104589 Sat, 19 Dec 2009 15:54:03 +0100 3104589 http://www.medworm.com/index.php?rid=3104587&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003837%26dopt%3DAbstract CONCLUSION: In our study, the association of the MTHFR c.677C > T genotype with plasma homocysteine levels was weakened by other factors that impact homocysteine levels. The effect of MTHFR c.677C > T on plasma homocysteine levels may, thus, be of major importance for healthy, young, non-smoking persons. Such specifications may explain the controversial results of epidemiological studies on the relevance of MTHFR c.677C > T. PMID: 20003837 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104587 Sat, 19 Dec 2009 15:54:03 +0100 3104587 http://www.medworm.com/index.php?rid=3104584&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003838%26dopt%3DAbstract CONCLUSIONS: CRM1 expression demonstrated prognostic value in pancreatic cancer. Prospective studies are required to determine the prognostic role of high expression of CRM1 in pancreatic cancer. PMID: 20003838 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104584 Sat, 19 Dec 2009 15:54:03 +0100 3104584 http://www.medworm.com/index.php?rid=3104583&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20003839%26dopt%3DAbstract CONCLUSION: Short-term treatment with creatine and metformin elicits similar glucose lowering effects in recently detected type II diabetics. Further studies are necessary to determine the effect of creatine on long-term glucose and insulin regulation. PMID: 20003839 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=3104583 Sat, 19 Dec 2009 15:54:03 +0100 3104583 http://www.medworm.com/index.php?rid=2858088&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796570%26dopt%3DAbstract CONCLUSION: Increased SBP, DBP, MAP and PP at admission were all associated with in-hospital mortality, and increased SBP, DBP and MAP were associated with dependency at discharge among hemorrhagic stroke patients. PMID: 19796570 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858088 Sun, 04 Oct 2009 15:00:02 +0100 2858088 http://www.medworm.com/index.php?rid=2858087&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796571%26dopt%3DAbstract CONCLUSION: The study revealed neuroprotective effects of VE on ischemic damage in diabetic central neuronal cells, caused by diabetic oxidative stress. PMID: 19796571 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858087 Sun, 04 Oct 2009 15:00:02 +0100 2858087 http://www.medworm.com/index.php?rid=2858086&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796572%26dopt%3DAbstract CONCLUSION: There is no relationship between ivabradine therapy and increased risk of ventricular and atrial arrhythmia in coronary artery disease patient. PMID: 19796572 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858086 Sun, 04 Oct 2009 15:00:02 +0100 2858086 http://www.medworm.com/index.php?rid=2858085&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796573%26dopt%3DAbstract CONCLUSION: In asthmatic children, when total oxidant status, total antioxidant capacity and lipid hydroperoxidation levels increase, paraoxonase activity decreased. PMID: 19796573 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858085 Sun, 04 Oct 2009 15:00:02 +0100 2858085 http://www.medworm.com/index.php?rid=2858084&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796574%26dopt%3DAbstract CONCLUSION: Thyroid arterial embolization can decrease the expression of VEGF, bFGF and MVD. Consequently, angiogenesis within the GD thyroid will be decreased in the long term after embolization and may serve as the basis for reduced thyroid size and function. PMID: 19796574 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858084 Sun, 04 Oct 2009 15:00:02 +0100 2858084 http://www.medworm.com/index.php?rid=2858083&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796575%26dopt%3DAbstract CONCLUSION: The results of this study of lymphocyte apoptosis are important in understanding of the disease pathogenesis and should be taken into account in elaboration of treatment strategies. PMID: 19796575 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858083 Sun, 04 Oct 2009 15:00:02 +0100 2858083 http://www.medworm.com/index.php?rid=2858082&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796576%26dopt%3DAbstract CONCLUSIONS: In a clonally heterogeneous population of pediatric community-acquired SA infections, pvl+ strains were associated with abscess formation and erythromycin susceptibility, but not invasive disease. PMID: 19796576 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858082 Sun, 04 Oct 2009 15:00:02 +0100 2858082 http://www.medworm.com/index.php?rid=2858081&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796577%26dopt%3DAbstract CONCLUSION: Daily smoking increases the risk of LBP among young adults, and this effect seems to be dose-dependent. Back pain treatment programs may benefit from integrating smoking habit modification. Further research is required to develop effective prevention strategies. PMID: 19796577 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858081 Sun, 04 Oct 2009 15:00:02 +0100 2858081 http://www.medworm.com/index.php?rid=2858080&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796578%26dopt%3DAbstract CONCLUSION: HSS has a potential cytotoxic effect on human ovarian cancer cells, which was mediated by multiple signal molecules including bcl-2, caspase-3, beta-catenin, and CD24. These findings will provide a theoretical basis for HSS's potential clinical application as a novel marine anti-cancer agent. PMID: 19796578 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858080 Sun, 04 Oct 2009 15:00:02 +0100 2858080 http://www.medworm.com/index.php?rid=2858079&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796579%26dopt%3DAbstract CONCLUSION: Radiotherapy has a negative effect on distraction osteogenesis, even if performed on a different part of the bone. PMID: 19796579 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858079 Sun, 04 Oct 2009 15:00:02 +0100 2858079 http://www.medworm.com/index.php?rid=2858078&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796580%26dopt%3DAbstract CONCLUSION: LXR beta-selective agonists and LXR modulators, which act as agonists in macrophages and induce cholesterol efflux while as antagonists of lipogenesis in the liver, are two critical and attractive approaches to treat atherosclerosis and cardiovascular diseases. PMID: 19796580 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858078 Sun, 04 Oct 2009 15:00:02 +0100 2858078 http://www.medworm.com/index.php?rid=2858077&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796581%26dopt%3DAbstract Authors: Rouleau JL In response to the growing gap between discovery and the optimal application of medical advancements to health care delivery, countries the world over have developed large and well funded programs to reduce these gaps. Although these programs vary in nature, they have generally largely focused more on reducing the gap in bench to bedside research. Canada's strong biomedical and patient oriented research (POR) community has a strong base from which to build, but requires support in order to fill the missing elements needed to take full advantage of the important unmet needs in health related research. In Canada, a coalition of funders of medical research, led by the Canadian Institutes for Health Research (CIHR) is developing a large and comprehensive program to buil... Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858077 Sun, 04 Oct 2009 15:00:02 +0100 2858077 http://www.medworm.com/index.php?rid=2858076&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19796582%26dopt%3DAbstract CONCLUSIONS: Cardiac troponin elevation is common and observed in 40 to 50% of critically ill medical and surgical patients. Elevated levels appear to identify patients at increased risk for death in the intensive care unit or hospital setting. This finding, and its relation to myocardial infarction and acute coronary syndromes, requires prospective study to better understand the implications for diagnosis and management. PMID: 19796582 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2858076 Sun, 04 Oct 2009 15:00:02 +0100 2858076 http://www.medworm.com/index.php?rid=2658606&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640328%26dopt%3DAbstract CONCLUSIONS: A short period, 15-20 min, of maximal exercise leads to A/C ratios above the microalbuminuria threshold in a substantial proportion of normal subjects. Physicians should not measure urine albumin in patients who give a history of such activity in the past 24 hr. PMID: 19640328 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2658606 Sat, 01 Aug 2009 05:30:03 +0100 2658606 http://www.medworm.com/index.php?rid=2658605&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640329%26dopt%3DAbstract CONCLUSION: The present study shows that the serum level of p53 is lower in the patients with type 2 diabetes than in controls or in subjects with IGT. No difference was seen among the the groups for the serum level of cytochrome c. PMID: 19640329 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2658605 Sat, 01 Aug 2009 05:30:03 +0100 2658605 http://www.medworm.com/index.php?rid=2658604&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640330%26dopt%3DAbstract CONCLUSION: Adiponectin levels were higher in type 1 diabetes. The association between C-peptide and adiponectin is probably one of the reasons for their different respective levels in different types of diabetes. Interrelations between adiponectin and inflammation, dyslipidemia, C-peptide levels and sex appear to be important for complex adiponectin modulation and action. PMID: 19640330 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2658604 Sat, 01 Aug 2009 05:30:03 +0100 2658604 http://www.medworm.com/index.php?rid=2658603&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640331%26dopt%3DAbstract CONCLUSIONS: Short-term treatment with simvastatin reduces plasma IL-6. The anti-inflammatory effect of simvastatin may contribute to its beneficial effects on the ventricular function and angina control. PMID: 19640331 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2658603 Sat, 01 Aug 2009 05:30:03 +0100 2658603 http://www.medworm.com/index.php?rid=2658602&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640332%26dopt%3DAbstract CONCLUSIONS: RV function deteriorated in STEMI compared with healthy controls. Contrary to the expectation, RV dysfunction was observed in anterior STEMI, but not in non anterior MI. There was no difference in RV function between the two treatment modalities. PMID: 19640332 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2658602 Sat, 01 Aug 2009 05:30:03 +0100 2658602 http://www.medworm.com/index.php?rid=2658601&cid=s_38100_61_f&fid=38100&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640333%26dopt%3DAbstract CONCLUSIONS: Determination of TIMP-2 in pleural fluid may contribute to differentiate TP from MP. These results suggest that overproduction of MMP-9 and TIMP-2 is associated with accumulation of the pleural effusion in malignancy. Further studies with a greater number of patients are needed to confirm this hypothesis. PMID: 19640333 [PubMed - in process] (Source: Clinical and Investigative Medicine) Clinical and Investigative Medicine journals http://www.medworm.com/rss/comments.php?id=2658601 Sat, 01 Aug 2009 05:30:03 +0100 2658601