MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical and Laboratory Haematology' source. Wed, 08 Feb 2012 17:41:59 +0100 http://www.medworm.com/index.php?rid=5668093&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2012.01402.x SummaryHairy cell leukaemia (HCL) has distinct clinical, morphological and immunophenotypic features with no recurrent cytogenetic or molecular abnormalities reported until the recent description of the BRAF V600E mutation in patients with classical HCL. The incidence of this mutation was sought in 27 patients with either classical HCL or HCL variant by an allele‐specific PCR approach and findings related to morphology, cytochemistry and immunophenotype. A high degree of correlation was noted between the presence of BRAF V600E and established diagnostic criteria in 26/27 patients with HCL/HCL variant. Detection of the BRAF V600E mutation is therefore a useful adjunct in the differential diagnosis of HCL and HCL variant and highlights the value of a multifaceted approach to the diagnosis ... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5668093 Wed, 01 Feb 2012 05:00:00 +0100 5668093 http://www.medworm.com/index.php?rid=5639114&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2012.01400.x Conclusion:  In this study, no significant differences on the frequency of TNF‐α, IL‐10, IL‐12 and CTLA‐4 polymorphisms between patients with AIHA and controls was found, suggesting that the targeted polymorphisms do not influence on the emergence and evolution of the disease. However, the LT‐α +252 polymorphism might have an effect for AIHAI development, suggesting that further studies are necessary to clear up this question. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5639114 Sun, 29 Jan 2012 22:04:02 +0100 5639114 http://www.medworm.com/index.php?rid=5629852&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01397.x Conclusion:  Flow cytometry is more sensitive than GT for assessing CTT‐DAT‐negative AIHA. We propose that FC percent fluorescence cut‐off values should be employed to determine the Coombs’ negative AIHA cases. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5629852 Thu, 26 Jan 2012 22:23:08 +0100 5629852 http://www.medworm.com/index.php?rid=5610032&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01388.x Conclusion:  βS Haplotyes were demonstrated successfully from dried blood samples. A new haplotype is apparent in Sudan, in addition to the four African haplotypes. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5610032 Fri, 20 Jan 2012 21:58:25 +0100 5610032 http://www.medworm.com/index.php?rid=5583357&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01392.x Conclusion:  In conclusion, the implementation of leukocytes CPD parameters can be useful in the detection of viral infection in children. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5583357 Sat, 14 Jan 2012 07:27:23 +0100 5583357 http://www.medworm.com/index.php?rid=5583358&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01396.x Conclusion:  To harmonize our procedures, we propose definitions of platelet size (normal size, macroplatelets and giant platelets) based on the coordinated interpretation of the MPV, the distribution of platelet volume and the morphological appearance. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5583358 Mon, 09 Jan 2012 05:00:00 +0100 5583358 http://www.medworm.com/index.php?rid=5561185&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01398.x Conclusion:  Symptoms of severe falciparum malaria depend on many factors. For the definition of hyperparasitemia in areas of low or seasonal transmission, peripheral parasitemia of 0.5% might be considered a cutoff point for discrimination between severity levels. This value might be useful for the clinical management of malaria, particularly in hypo‐endemic areas, unstable transmission areas, and other areas with similar transmission patterns. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5561185 Thu, 05 Jan 2012 21:46:06 +0100 5561185 http://www.medworm.com/index.php?rid=5553038&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01393.x Conclusion.  A case of MPAL with complex biological features, 45,XY, dic(11;17)(11qter→11p11.2::17p11.2→17qter) karyotype and an aggressive, therapy‐resistant clinical course, is presented. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5553038 Sat, 31 Dec 2011 20:02:41 +0100 5553038 http://www.medworm.com/index.php?rid=5553039&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01394.x Conclusion:  Neutrophil CPD, MNV, and NDW are better indicators for postoperative bacterial infection. The potential clinical usefulness of these parameters merits further exploration in a larger prospective study. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5553039 Thu, 29 Dec 2011 05:00:00 +0100 5553039 http://www.medworm.com/index.php?rid=5545181&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01390.x SummaryMultifactorial pathogenetic features underlying myelodysplastic syndromes (MDS) relate to inherent abnormalities within the hematopoietic precursor cell population. The predominant final common pathogenetic pathway causing ineffective hematopoiesis in MDS has been the varying degrees of apoptosis of the hematopoietic precursors and their progeny. A variety of molecular abnormalities have been demonstrated in MDS. These lesions are attributable to nonrandom cytogenetic and oncogenic mutations, indicative of chromosomal and genetic instability, transcriptional RNA splicing abnormalities, and epigenetic changes. Evolutionary cytogenetic changes may occur during the course of the disorder, which are associated with disease progression. These genetic derangements reflect a multistep proc... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5545181 Wed, 28 Dec 2011 13:53:50 +0100 5545181 http://www.medworm.com/index.php?rid=5526235&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01395.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5526235 Thu, 22 Dec 2011 10:27:21 +0100 5526235 http://www.medworm.com/index.php?rid=5477388&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01384.x Conclusion:  Bortezomib is a promising potential therapy for acute leukemia, especially mdr1 drug‐resistant leukemia. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5477388 Wed, 07 Dec 2011 05:00:00 +0100 5477388 http://www.medworm.com/index.php?rid=5477387&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01387.x Conclusions:  The crush technique seems to be more valuable than the wedge‐spread technique because of the lack of a blood dilution effect and better assessment of megakaryopoiesis. We recommend the crush technique for the evaluation of the percentage composition of bone marrow cells. In a very small number of patients with irregular cell localization in the bone marrow particles, the wedge‐spread technique may be more beneficial for the assessment of total cellularity. The recommendation to routinely prepare slides using both of these techniques is fully justified. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5477387 Wed, 07 Dec 2011 05:00:00 +0100 5477387 http://www.medworm.com/index.php?rid=5506082&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01386.x Conclusion:  The results indicate that the risk of acute leukemia might be associated with JAK2 polymorphisms. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5506082 Thu, 01 Dec 2011 05:00:00 +0100 5506082 http://www.medworm.com/index.php?rid=5487856&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01391.x Conclusions:  The new RBC parameters of CELL‐DYN Sapphire generally correlated well with those of Advia 120, although significant systematic differences were present, particularly in reticulocyte MCH and MCV. These differences necessitate instrument‐specific reference ranges and clinical decision values. To minimize preanalytical effects, these parameters should be measured in fresh blood samples. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5487856 Thu, 01 Dec 2011 05:00:00 +0100 5487856 http://www.medworm.com/index.php?rid=5477386&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01389.x Conclusion:  A group of proteins associated with BC can be obtained and the result of this study might provide clues for further research. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5477386 Thu, 01 Dec 2011 05:00:00 +0100 5477386 http://www.medworm.com/index.php?rid=5458838&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01385.x We describe here a rare chromosomal rearrangement, t(14;19)(q11.2;q13.3), in a Lennert’s lymphoma, a variant of PTCL, not otherwise specified. Sequential fluorescence in situ hybridization assays showed that the breakpoint in 19q13.3 was located distal to the BCL3 and PVRL2 genes, both of which may be candidate proto‐oncogenes. These findings suggest that another gene is involved in the pathogenic characteristics observed in this patient with Lennert’s lymphoma. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5458838 Thu, 01 Dec 2011 05:00:00 +0100 5458838 http://www.medworm.com/index.php?rid=5409579&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01382.x Conclusion:  In this collective of subjectively healthy elderly individuals, monocyte anisocytosis, neutrophil anisocytosis and mean lymphocyte volume were associated with decreased HoloTC. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5409579 Thu, 17 Nov 2011 01:23:48 +0100 5409579 http://www.medworm.com/index.php?rid=5409580&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01380.x SummarySchistocytes are fragments of red blood cells (RBCs) produced by extrinsic mechanical damage within the circulation. The detection of schistocytes is an important morphological clue to the diagnosis of thrombotic microangiopathic anemia (TMA). Reporting criteria between different laboratories, however, are not uniform, owing to variability of shape and nature of fragments, as well as subjectivity and heterogeneity in their morphological assessment. Lack of standardization may lead to inconsistency or misdiagnosis, thereby affecting treatment and clinical outcome. The Schistocyte Working Group of the International Council for Standardization in Haematology (ICSH) has prepared specific recommendations to standardize schistocyte identification, enumeration, and reporting. They deal wit... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5409580 Tue, 15 Nov 2011 05:00:00 +0100 5409580 http://www.medworm.com/index.php?rid=5409581&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01381.x Conclusion:  Determination of P5′N‐1 activity by using an ELISA reader is a new, simple, less time consuming and reliable method. It also avoids the use of radioactive material or HPLC which is a significant advantage. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5409581 Mon, 14 Nov 2011 05:00:00 +0100 5409581 http://www.medworm.com/index.php?rid=5401341&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01383.x Conclusion:  DxH800™ provides very sensitive and specific, easily recognizable P. vivax malaria signals on routine CBC without need for the additional reagents or special procedures. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5401341 Sun, 13 Nov 2011 10:11:46 +0100 5401341 http://www.medworm.com/index.php?rid=5388795&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01379.x Conclusion:  We suggest that in healthy individuals, a typical smear would contain several nondiscoid‐shaped erythrocytes, only clearly visible at high magnification. However, thromboembolic ischemic stroke does significantly impact erythorcyte shape, and this change in morphology may result in an impaired microcirculation, as well as impaired oxygen carrying capacity. This changed morphology may further complicate the restoring of homeostasis caused by acute thromboembolic stroke. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5388795 Thu, 10 Nov 2011 11:29:59 +0100 5388795 http://www.medworm.com/index.php?rid=5388796&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01378.x Conclusion:  The results of routine hematological testing on mildly to frankly hemolyzed specimens might be unreliable. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5388796 Wed, 02 Nov 2011 04:00:00 +0100 5388796 http://www.medworm.com/index.php?rid=5362624&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01376.x Conclusion:  The combination of mixing and confirmatory tests interpreted according to the new guidelines can clearly differentiate LA from other coagulopathies. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5362624 Wed, 02 Nov 2011 00:24:11 +0100 5362624 http://www.medworm.com/index.php?rid=5316311&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01377.x Conclusion:  The decrease in blood catalase activity might be due to the damaging effects of free radicals on the catalase protein. Consequently, these beta‐thalassemia trait patients may be relatively susceptible to damage caused by oxidative stress. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5316311 Sat, 01 Oct 2011 04:00:00 +0100 5316311 http://www.medworm.com/index.php?rid=5286650&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01368.x SummaryAlthough DNA analysis is needed for characterization of the mutations that cause β‐thalassaemia, measurement of the Hb A2 is essential for the routine identification of people who are carriers of β‐thalassaemia. The methods of quantitating Hb A2 are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high‐performance liquid chromatography and capillary electrophoresis. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5286650 Sat, 01 Oct 2011 04:00:00 +0100 5286650 http://www.medworm.com/index.php?rid=5261782&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01375.x Conclusion:  Our findings clearly show that type 2 polarization of the autoimmune response accounts for the expression of cytokines and transcription factors in EBV‐ITP. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5261782 Thu, 29 Sep 2011 09:50:58 +0100 5261782 http://www.medworm.com/index.php?rid=5227152&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01367.x SummaryMeasurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto‐maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high‐performance liquid chromatography and capillary electrophoresis. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5227152 Mon, 19 Sep 2011 02:33:35 +0100 5227152 http://www.medworm.com/index.php?rid=5197009&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01374.x SummaryThe recently updated World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues, published in 2008, has made great advances in revising the disorders previously included in the pool of natural killer (NK) cell tumors. Although NK cell neoplasms represent a relatively rare group of diseases, accounting for <5% of all lymphoid neoplasms, they include very distinctive conditions both clinically and pathologically. This family of diseases includes the most indolent clinical forms, such as the provisional new entry of chronic lymphoproliferative disorder of NK cells (CLPD‐NK) in the WHO classification, as well as one of the most fatal diseases recognized in medical oncology, aggressive NK cell leukemia (ANKL), which is characterized by a prognosis... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5197009 Wed, 07 Sep 2011 07:48:13 +0100 5197009 http://www.medworm.com/index.php?rid=5197011&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01372.x Conclusion:  Hemoglobin Lepore Hollandia is a relatively uncommon variant in the Indian population and can be identified using a combination of chromatographic, electrophoretic, and molecular analysis. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5197011 Mon, 05 Sep 2011 23:00:00 +0100 5197011 http://www.medworm.com/index.php?rid=5197010&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01373.x Conclusion:  The ABX Pentra DX 120 provided accurate WBC count and differential count during MB, LP, and CB analyses and allowed a better characterization of donors’ hematologic status and graft composition. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5197010 Mon, 05 Sep 2011 23:00:00 +0100 5197010 http://www.medworm.com/index.php?rid=5163387&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01366.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5163387 Sat, 27 Aug 2011 16:24:31 +0100 5163387 http://www.medworm.com/index.php?rid=5163381&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01364.x SummaryThe identification of the molecular genetic basis to many haematological malignancies along with the increased use of molecularly targeted therapy has heralded an increasing role for molecular genetic–based techniques. Demonstration of acquired changes such as the JAK2 V617F mutation within myeloproliferative neoplasms has quickly moved from a research setting to the diagnostic laboratory. Disease‐specific genetic markers, such as the BCR–ABL1 fusion gene in chronic myeloid leukaemia, enable sensitive molecular genetic methods to be applied for the detection and quantification of low‐level residual disease, allowing early identification of relapse. Consequently, molecular genetics now plays a crucial role in diagnosis, the identification of prognostic markers and monitoring ... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5163381 Sat, 27 Aug 2011 16:23:53 +0100 5163381 http://www.medworm.com/index.php?rid=5163382&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01371.x Conclusion:  CE is the preferable method for screening of heterozygote and homozygote of Hb CS. Moreover, in conjunction with a lower MCV (<70 fL), this approach provided a high resolution to identify Hb H‐CS disease. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5163382 Thu, 25 Aug 2011 23:00:00 +0100 5163382 http://www.medworm.com/index.php?rid=5163385&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01361.x Conclusion:  A minimal panel of immunohistochemical markers should include anti‐CD43 or anti‐lysozyme as a lack of immunoreactivity for either of these sensitive markers would be inconsistent with a diagnosis of myeloid sarcoma. Use of more specific markers of myeloid disease, such as CD33, myeloperoxidase, CD34 and CD117 is necessary to establish the diagnosis. Other antibodies may be added depending on the differential diagnosis. Identification of acute myeloid leukemia‐associated genetic lesions may be helpful in arriving at the correct diagnosis. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5163385 Tue, 23 Aug 2011 23:00:00 +0100 5163385 http://www.medworm.com/index.php?rid=5163384&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01365.x Conclusion:  We concluded that in the presence of a normal WBC and haemoglobin, the FBC is normal in almost all cases and measuring these two parameters could be used as an effective screen to predict FBC normality. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5163384 Tue, 23 Aug 2011 23:00:00 +0100 5163384 http://www.medworm.com/index.php?rid=5163383&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01369.x Conclusion:  Alterations of proteins, lipids, and ions in the plasma and erythrocyte of steady‐state patients with SCA were demonstrated. Some of these alterations are related with each other and with the oxidative stress observed in the disease. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5163383 Tue, 23 Aug 2011 23:00:00 +0100 5163383 http://www.medworm.com/index.php?rid=5163386&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01357.x Conclusion:  The described novel test tube method could be an alternative method of mass population screening for HbE, particularly in small health care facilities. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5163386 Mon, 22 Aug 2011 23:00:00 +0100 5163386 http://www.medworm.com/index.php?rid=5120452&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01370.x Conclusion:  Measurement of Ca‐I‐activated CL enhanced with 10−4 m luminol is recommended for the detection of intracellular ROS. The addition of HRP leads to the detection of overall ROS production while the OZP‐activated system with its addition of HRP can only be used to detect overall ROS production. Ca‐I‐activated CL enhanced with 10−4 m isoluminol and with addition of HRP is recommended for the detection of extracellular CL. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5120452 Sun, 31 Jul 2011 23:00:00 +0100 5120452 http://www.medworm.com/index.php?rid=5070551&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01363.x Conclusion:  All POCT devices tested and operated by trained staff for hemoglobinometry showed reliable test results. They all allow for simple, fast, and precise bedside determination of hemoglobin concentration in the intraoperative setting. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5070551 Thu, 28 Jul 2011 04:59:55 +0100 5070551 http://www.medworm.com/index.php?rid=5070553&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01360.x Conclusion:  Our data demonstrate the importance of centrifugation speed in the interpretation of LTA results, supporting the need for standardization of centrifugation RCF in LTA protocols. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5070553 Tue, 26 Jul 2011 23:00:00 +0100 5070553 http://www.medworm.com/index.php?rid=5070552&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01362.x We describe a case of 2M VWD ‘masquerading’ as type 1 and show how the differential diagnosis can be obtained using standard laboratory assays. The case was genetically confirmed as a 3943C>T mutation, leading to R1315C. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5070552 Tue, 26 Jul 2011 23:00:00 +0100 5070552 http://www.medworm.com/index.php?rid=5031258&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01358.x Conclusion:  Anti‐HPA‐15 antibody detection should be based on carefully selected platelets with high HPA‐15 expression level. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5031258 Sat, 16 Jul 2011 17:30:08 +0100 5031258 http://www.medworm.com/index.php?rid=5031259&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01359.x Conclusion:  The study emphasizes large variation in the approach to managing these scenarios and warrants further investigation, together with education including promoting national guidelines for the assignment of target ranges. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5031259 Wed, 13 Jul 2011 23:00:00 +0100 5031259 http://www.medworm.com/index.php?rid=5000037&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01352.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5000037 Wed, 06 Jul 2011 15:51:15 +0100 5000037 http://www.medworm.com/index.php?rid=5000039&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01355.x Conclusion:  LHD% is a reliable parameter for the detection of iron deficiency in patients with anemia in the presence of inflammation. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5000039 Sun, 03 Jul 2011 23:00:00 +0100 5000039 http://www.medworm.com/index.php?rid=5000038&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01356.x Conclusion:  There are statistically significant differences between sampling sites, although samples from the VA do not appear to be more pro‐thrombotic. Future studies comparing HD patients with controls should ensure uniformity of sampling sites to prevent inaccurate conclusions being drawn. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5000038 Sun, 03 Jul 2011 23:00:00 +0100 5000038 http://www.medworm.com/index.php?rid=4978205&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01354.x Conclusion:  This study revealed the potential of IPM microvesicles to mimic the binding features of platelets in vitro. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4978205 Wed, 29 Jun 2011 18:03:13 +0100 4978205 http://www.medworm.com/index.php?rid=5197012&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01351.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=5197012 Sun, 26 Jun 2011 23:00:00 +0100 5197012 http://www.medworm.com/index.php?rid=4978209&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01347.x SummaryA 2‐year‐old girl presented to casualty with a right knee effusion after apparently minor trauma. Inflicted injury was suspected and full forensic coagulation studies were performed which revealed a mild deficiency of factor VIII. Screening of the exons and intron/exon boundaries of F8 gene indicated that the child appeared to be homozygous for the missense mutation c.5123G>A (p.Arg1708His) in exon 14 of the F8 gene. This mutation has been reported to be associated with mild haemophilia A. The possibility of hemizygosity had been masked by the test kit employed but referral to the genetics service and subsequent array CGH resulted in a diagnosis of Turner syndrome. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4978209 Sun, 26 Jun 2011 23:00:00 +0100 4978209 http://www.medworm.com/index.php?rid=4978208&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01348.x Conclusion:  We conclude that Ret % and [Hb] remain stable over four consecutive seasons in elite triathletes, confirming that both parameters are valid for antidoping purposes based on the Blood Passport. In addition, Ret % fluctuations within one season require further investigation in females. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4978208 Sun, 26 Jun 2011 23:00:00 +0100 4978208 http://www.medworm.com/index.php?rid=4978207&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01349.x Conclusion:  These findings suggest that in patients to whom FVIII is administered on demand the fibrinolysis activity is more down regulated than in patients following a prophylactic treatment regime. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4978207 Sun, 26 Jun 2011 23:00:00 +0100 4978207 http://www.medworm.com/index.php?rid=4978206&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01351.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4978206 Sun, 26 Jun 2011 23:00:00 +0100 4978206 http://www.medworm.com/index.php?rid=4962056&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01345.x SummaryCharacterisation of heritable thrombophilic defects has facilitated an understanding of the complex mechanisms influencing risk of venous thromboembolism. In parallel with this, the importance of gene–environment interaction in the development of this disease has become apparent. However, testing for a limited number of heritable thrombophilic defects (first generation thrombophilia testing) has not been shown to predict likelihood of recurrent venous thrombosis to any useful degree. This paradox whereby thrombophilia testing identifies defects associated with an increased risk of a first venous thrombosis but not of a particularly high risk of recurrence is likely the result of limitations imposed by a limited dichotomous testing strategy compounded by test inaccuracy and impreci... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4962056 Fri, 24 Jun 2011 14:51:43 +0100 4962056 http://www.medworm.com/index.php?rid=4962054&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01350.x This study aimed to quantify unnecessary repeat haematinic tests taken from the elderly in a district general hospital. Haematinic tests (ferritin, B12, serum folate) from patients age ≥70 years were reviewed for repeat tests during an 8‐week period. Questionnaires were given to doctors to establish when the considered repeating a ‘borderline low normal’ result to be clinically justifiable. 7.7% of all haematinic tests were repeat tests and of these, the majority (83%) was performed following a previously normal result. Thirteen of 24 doctors believed repeating a normal result at the bottom of the normal range (‘borderline low normal’) was justifiable. After excluding ‘borderline low normal’ results, 6.0% (at minimum) of repeat tests were done following a previous normal ... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4962054 Fri, 24 Jun 2011 14:50:58 +0100 4962054 http://www.medworm.com/index.php?rid=4962055&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01346.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4962055 Tue, 21 Jun 2011 23:00:00 +0100 4962055 http://www.medworm.com/index.php?rid=4938768&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01340.x Conclusion: ; Critical control of the factors influencing the LS1+ flag can significantly decrease the number of microscopic samples to be reviewed and may be valuable for every laboratory performing routine differentials, using any type of hematology analyzer. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4938768 Wed, 15 Jun 2011 23:00:00 +0100 4938768 http://www.medworm.com/index.php?rid=4938767&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01343.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4938767 Wed, 15 Jun 2011 23:00:00 +0100 4938767 http://www.medworm.com/index.php?rid=4938766&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01341.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4938766 Wed, 15 Jun 2011 23:00:00 +0100 4938766 http://www.medworm.com/index.php?rid=4923885&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01344.x Conclusion:  The single closed‐tube Tm‐shift method for HPA‐15 genotyping is high‐throughput, rapid, reliable, reproducible and cost‐effective and it is superior to conventional PCR‐SSP used in routine genotyping of HPA‐15. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4923885 Sun, 12 Jun 2011 23:00:00 +0100 4923885 http://www.medworm.com/index.php?rid=4923884&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01342.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4923884 Sun, 12 Jun 2011 23:00:00 +0100 4923884 http://www.medworm.com/index.php?rid=4904889&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01337.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4904889 Sun, 05 Jun 2011 23:00:00 +0100 4904889 http://www.medworm.com/index.php?rid=4904888&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01333.x We describe a case of l‐asparaginase‐associated severe hyperlipidemia with complete blood count abnormalities. Complete blood count analysis was performed with Beckman COULTER® GEN·S™ system, which uses the Coulter Volume, Conductivity, Scatter technology to probe hydrodynamically focused cells. Although an expected significant inaccuracy in hemoglobin determination occurred starting from a lipid value of 3450 mg/dl, we observed that triglyceride level was 1466 mg/dl. Complete blood count analysis revealed that exceptionally high hemoglobin, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration levels vs. discordant with red blood cell count, mean corpuscular volume, and hematocrit levels. Total leukocyte count altered spontaneously in a wide range, and was... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4904888 Sun, 05 Jun 2011 23:00:00 +0100 4904888 http://www.medworm.com/index.php?rid=4938765&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01353.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4938765 Tue, 31 May 2011 23:00:00 +0100 4938765 http://www.medworm.com/index.php?rid=4923883&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01339.x Conclusion:  Our study revealed a lower mean CV for the total cell count for the XE‐5000 method. The fully automated CSF cell count results in a 7.5‐fold reduction in TAT and leads to a significant decrease in total analytical performance costs. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4923883 Tue, 31 May 2011 23:00:00 +0100 4923883 http://www.medworm.com/index.php?rid=4904887&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01336.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4904887 Tue, 31 May 2011 23:00:00 +0100 4904887 http://www.medworm.com/index.php?rid=4886286&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01335.x Conclusion:  The results obtained indicate the UniCel DxH 800 to be an excellent test on neonatal blood and superior to the other analyzers. Therefore, the DxH 800 is an effective and highly sensitive system for the analysis of NRBCs on newborns. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4886286 Tue, 31 May 2011 23:00:00 +0100 4886286 http://www.medworm.com/index.php?rid=4886285&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01338.x Conclusion:  The method is valid for accurate quantification of Hb at a wide concentration range (>0.1 μm/L) in erythroid precursors or plasma and is optional for other biological fluids. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4886285 Tue, 31 May 2011 23:00:00 +0100 4886285 http://www.medworm.com/index.php?rid=4854972&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01322.x Conclusion:  Circulating ECs might be associated with systemic aGVHD. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4854972 Tue, 24 May 2011 17:35:32 +0100 4854972 http://www.medworm.com/index.php?rid=4832671&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01334.x Conclusion:  We suggested using roller mixer to improve the reliability of coagulation testing. Such standardization in preanalytical phase may be helpful in preventing laboratory errors and obtaining correct test results in coagulation tests. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4832671 Wed, 18 May 2011 18:39:50 +0100 4832671 http://www.medworm.com/index.php?rid=4832673&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01332.x Conclusion:  To enhance the appropriate use of hereditary thrombophilia screening tests, physician education concerning the patient selection, suitable timing for testing and repetition of the tests with abnormal results should be emphasized. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4832673 Sun, 15 May 2011 23:00:00 +0100 4832673 http://www.medworm.com/index.php?rid=4832672&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01331.x SummaryAntithrombin inhibits VIIa when bound to cellular tissue factor in the presence of heparin. VIIa concentrations increase within the surgical field during cardiopulmonary bypass surgery but decrease when measured in the patient. Using a new ELISA (Stago, Reading, UK), we measured VIIa–antithrombin complexes in patients undergoing cardiopulmonary bypass to determine whether antithrombin plays a physiological role in VIIa inhibition during cardiac surgery. Samples were taken from 13 adult patients undergoing cardiac surgery with cardiopulmonary bypass at the following time points: presurgery, postheparin, 20 min intervals during cardiopulmonary bypass and postprotamine. The presurgery concentrations of VIIa–antithrombin complexes were median of 52.7pm, and these rose postheparin ... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4832672 Sun, 15 May 2011 23:00:00 +0100 4832672 http://www.medworm.com/index.php?rid=4790762&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01327.x Conclusion:  Sampling for pO2 determination should be carried out in small volumes and assessed within 30 min of collection to obtain reliable and comparable results. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4790762 Fri, 06 May 2011 17:24:48 +0100 4790762 http://www.medworm.com/index.php?rid=4776544&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01315.x SummaryThe West Midlands Newborn Screening Laboratory (NBSL) at Birmingham Children’s Hospital (BCH), UK, screens approximately 71 000 babies per annum using the Bio‐Rad automated VARIANT™ nbs (Vnbs) high‐pressure liquid chromatograph (HPLC). Any abnormal haemoglobins detected, including S, C, D‐Punjab, E and O‐Arab as directed by the NHS Sickle Cell and Thalassaemia Screening Programme (NHS Sickle Cell and Thalassaemia Screening Programme Website, http://sct.screening.nhs.uk), are then confirmed using Resolve® isoelectric electric focusing (IEF) kits supplied by Perkin‐Elmer. The Sebia capillarys Neonat Haemoglobin FAST™ system was evaluated as a possible replacement for the first‐ or second‐line methods used. Both the Sebia and Bio‐Rad methods were compared using... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4776544 Tue, 03 May 2011 16:55:03 +0100 4776544 http://www.medworm.com/index.php?rid=4776545&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01326.x Conclusion:  The INNOVANCE Antithrombin assay has high sensitivity for Antithrombin deficiencies and is reliable, precise and suitable for routine clinical use. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4776545 Mon, 02 May 2011 23:00:00 +0100 4776545 http://www.medworm.com/index.php?rid=4736805&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01325.x Conclusion:  We concluded that 563C‐T was the commonest G6PD variant, while 1003A‐G and 131C‐G were less‐frequent genetic variants of G6PD in Pakistani population. A novel genetic variant 973G‐A was also identified. Very low levels of G6PD enzyme activity was seen with G6PD 563C‐T. Mutational analysis failed in a significant proportion of samples warranting further work. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4736805 Fri, 22 Apr 2011 17:22:04 +0100 4736805 http://www.medworm.com/index.php?rid=4726542&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01309.x Conclusion:  Glucose‐6‐phosphate dehydrogenase heterozygote females cannot be identified by FST if fluorescence is reported as absent or present. Distinguishing samples with intermediate fluorescence from absent and bright fluorescence improves detection of heterozygote females with mild G6PD deficiency. Mutational studies confirmed that 85% of intermediate samples with normal enzyme activity had identifiable G6PD mutations. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4726542 Tue, 19 Apr 2011 17:36:45 +0100 4726542 http://www.medworm.com/index.php?rid=4716047&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01324.x Conclusion:  This study demonstrates a new and efficient method to amplify the CD34+ human cord blood hematopoietic stem/progenitor cells in a 3D alginate culture system ex vivo for extended periods while retaining the hematopoietic reconstruction capacity. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4716047 Fri, 15 Apr 2011 18:37:21 +0100 4716047 http://www.medworm.com/index.php?rid=4687231&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01317.x Conclusion:  Approximately 1/3 of PCM cases show IP changes over time, with CD45 the least stable antigen. Recognition of this relative instability is important to avoid narrow targeting of follow‐up FC analyses, especially for minimal residual disease monitoring. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4687231 Wed, 06 Apr 2011 23:00:00 +0100 4687231 http://www.medworm.com/index.php?rid=4687230&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01321.x Conclusion:  Stanleyville‐II gene mutation is HBA2:c.237C>A, or C>G, and this information on the Globin Gene Server should be updated; AfeI test is a fast and accurate method to detect it; NBS programs should consider the possibility of Hb Stanleyville‐II whenever IEF shows one band in the HbS position, and another one between S and C. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4687230 Wed, 06 Apr 2011 23:00:00 +0100 4687230 http://www.medworm.com/index.php?rid=4672253&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01313.x Conclusion:  Our data suggest that ZnPcH1‐PDT may be a useful modality for purging CML cells for autologous grafts. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4672253 Sun, 03 Apr 2011 23:00:00 +0100 4672253 http://www.medworm.com/index.php?rid=4672252&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01318.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4672252 Sun, 03 Apr 2011 23:00:00 +0100 4672252 http://www.medworm.com/index.php?rid=4687229&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01323.x Conclusion:  In PCN cases, an FC‐assessed 3% PCC in BM aspirates should not be used as a cut‐off for further FISH testing. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4687229 Thu, 31 Mar 2011 23:00:00 +0100 4687229 http://www.medworm.com/index.php?rid=4677919&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01320.x Conclusion:  According to our data, patients with low producer type of IL‐10 polymorphisms have more severe thrombocytopenia, suggesting that IL‐10 gene polymorphisms may reflect the severity of ITP. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4677919 Thu, 31 Mar 2011 23:00:00 +0100 4677919 http://www.medworm.com/index.php?rid=4672250&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01319.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4672250 Thu, 31 Mar 2011 23:00:00 +0100 4672250 http://www.medworm.com/index.php?rid=4645497&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01300.x Conclusion:  The present study revealed an association of pDCs, mDCs, γδT cells and Treg cells with induction or treatment of GVHD. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4645497 Tue, 29 Mar 2011 16:57:22 +0100 4645497 http://www.medworm.com/index.php?rid=4632722&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01316.x Conclusion: EaeI restriction enzyme digestion can be used as a simple and robust alternative method to ARMS‐PCR for DNA diagnosis of Hb Q‐India. The EaeI restriction enzyme can be added to the panel of restriction enzymes used in the DNA diagnosis of the abnormal Hb variants. Concomitant use of HPLC and IEF can be used efficiently for presumed diagnosis of this rare variant. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4632722 Fri, 25 Mar 2011 17:51:29 +0100 4632722 http://www.medworm.com/index.php?rid=4632725&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01310.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4632725 Thu, 24 Mar 2011 00:00:00 +0100 4632725 http://www.medworm.com/index.php?rid=4632724&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01314.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4632724 Thu, 24 Mar 2011 00:00:00 +0100 4632724 http://www.medworm.com/index.php?rid=4632723&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01308.x Conclusion:  The prevalence of overt MPN and that of JAK2 V617F were lower in Korean patients with SVT than in previous reports. Data from a larger number of patients with long‐term follow‐up are needed to reveal the clinical relevancy of JAK2 V617F in Korean patients with SVT. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4632723 Thu, 24 Mar 2011 00:00:00 +0100 4632723 http://www.medworm.com/index.php?rid=4617330&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01312.x We describe a female patient who presented with acquired haemolytic anaemia. Erythrophagocytosis was found in around 35% of neutrophils of the peripheral blood. A similar picture was seen in the bone marrow, but with additional erythrophagocytosis by macrophages. These two processes were considered as the main causes of anaemia, but the first one seemed to be predominant. Malignancies, autoimmunisation disorders and infections were excluded. Immunosuppressive therapy with corticosteroids was implemented, but had to be stopped because of side effects. Long‐term normalization of peripheral blood morphology was achieved after splenectomy. Splenectomy may be considered a therapeutic option for patients with diagnosed neutrophil erythrophagocytic hyperactivity. Therapy with corticosteroids is... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4617330 Tue, 22 Mar 2011 17:49:57 +0100 4617330 http://www.medworm.com/index.php?rid=4617332&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01306.x Conclusion:  Our data show that the slide‐making rates are variable in different hematology analyzers. It also implies that although MSR cannot be fully substituted by modern hematology analyzers, it can be effectively reduced to optimize laboratory workload. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4617332 Mon, 21 Mar 2011 00:00:00 +0100 4617332 http://www.medworm.com/index.php?rid=4617331&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01311.x Conclusion:  We demonstrate that coagulometric assays are not equally sensitive to clinically important functional defects of PC and that multiple assays may be required to identify all variants. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4617331 Mon, 21 Mar 2011 00:00:00 +0100 4617331 http://www.medworm.com/index.php?rid=4607137&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01305.x Conclusion:  As such, considering that inappropriate use of the tourniquet is commonplace, we conclude that transillumination devices can represent a suitable tool to eliminate the venous stasis and to improve the quality of phlebotomy procedures. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4607137 Fri, 18 Mar 2011 17:25:07 +0100 4607137 http://www.medworm.com/index.php?rid=4596476&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01307.x Conclusion:  AT activity assays are essential for the detection of AT deficiency because type II defects are relatively common in patients with heritable deficiency. No one functional assay can be assumed to detect all forms of AT deficiency, and assays can sometimes be improved by reducing reaction time of AT with thrombin or factor Xa. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4596476 Wed, 16 Mar 2011 17:33:27 +0100 4596476 http://www.medworm.com/index.php?rid=4562204&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01303.x Conclusion:  At our institution, transport of blood samples by pneumatic delivery does not influence ROTEM® parameters. Blood samples can be analysed centrally, and results transmitted live via virtual network computing to emergency or operating rooms. Prior to analyse blood samples centrally, the type of sample transport should be tested to exclude in vitro blood activation by local pneumatic transport system. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4562204 Wed, 09 Mar 2011 17:25:12 +0100 4562204 http://www.medworm.com/index.php?rid=4518595&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01302.x SummaryIn recognition of the need for a standardization of the measurement of the erythrocyte sedimentation rate (ESR), the International Council for Standardization in Haematology makes the following recommendations: (i) The reference method for measurement of the ESR should be based on the Westergren method, which is a specific test for the ESR, with modifications, (ii) The reference method for measurement of the ESR should use either whole blood anticoagulated with EDTA and later diluted with sodium citrate or saline (4 : 1) or whole blood anticoagulated with sodium citrate (4 : 1) in Westergren pipettes, (iii) The ESR pipettes can be of glass or plastic (with specific characteristics). It must be colourless; a minimum sedimentation scale of 200 mm, a minimum bore of 2.55 mm... Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4518595 Fri, 25 Feb 2011 00:00:00 +0100 4518595 http://www.medworm.com/index.php?rid=4518594&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01304.x Conclusion:  The NaOH method is a simple method that uses minimal equipment and reagents that make it labour‐ and cost‐effective. This method could be adopted by poorer countries to extract DNA for beta‐thalassaemia mutation characterization. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4518594 Fri, 25 Feb 2011 00:00:00 +0100 4518594 http://www.medworm.com/index.php?rid=4503214&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01298.x Conclusion:  Many of the leukocyte CPD have been identified as useful parameters of sepsis. Hopefully, these parameters can ultimately be incorporated into a decision rule for the screening of sepsis samples and to discriminate fungemia from bacteremia. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4503214 Tue, 22 Feb 2011 00:00:00 +0100 4503214 http://www.medworm.com/index.php?rid=4461184&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01296.x Conclusion:  MPV has limited sensitivity and specificity to discriminate between megaloblastic and non‐megaloblastic pancytopenia. Pancytopenia due to aplastic/hypocellular marrow and acute leukaemia has significantly lower MPV than megaloblastic group while other pancytopenic cases do not show any statistical difference in MPV from megaloblastic pancytopenia. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4461184 Thu, 10 Feb 2011 00:00:00 +0100 4461184 http://www.medworm.com/index.php?rid=4518593&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01299.x Conclusion:  East Asian DS neonates and children showed distinctive spectrum of hematological abnormalities. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4518593 Tue, 01 Feb 2011 00:00:00 +0100 4518593 http://www.medworm.com/index.php?rid=4503213&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01301.x Conclusion:  The capillary electrophoresis system could clearly demonstrate the presence of abnormal Hbs and provide useful information for presumptive diagnoses in most cases. The Hb analysis results could help in selection of appropriate DNA testing for final diagnoses of these variants. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4503213 Tue, 01 Feb 2011 00:00:00 +0100 4503213 http://www.medworm.com/index.php?rid=4461183&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2011.01297.x Conclusion:  Pretransplantation IO might be a major contributor to adverse outcome in HSCT recipients through an impaired pro‐oxidative/antioxidative homeostasis. The reversible nature of IO and oxidative stress suggests that early preventive strategies might have a potential to improve transplant outcome. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4461183 Tue, 01 Feb 2011 00:00:00 +0100 4461183 http://www.medworm.com/index.php?rid=4425479&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01292.x Conclusion:  In our experience, systematic schistocyte count after HSCT proved to be useful: the occurrence of an increased percentage was a surrogate marker for complications even if unspecific for TM. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4425479 Tue, 01 Feb 2011 00:00:00 +0100 4425479 http://www.medworm.com/index.php?rid=4407370&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01290.x Conclusion:  A variety of patterns of the IgH deletion were identified by interphase FISH using IgH break‐apart and IgH/CCND1 probes in patients with MM and CLL. The results of this study suggest that the integrated information obtained with IgH break‐apart and IgH/CCND1 FISH was needed to interpret FISH results unambiguously. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4407370 Fri, 28 Jan 2011 16:23:57 +0100 4407370 http://www.medworm.com/index.php?rid=4401452&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01289.x Conclusion:  A novel StyI restriction enzyme can be used to confirm the commonest type of Hb G‐Philadelphia. DNA sequencing identified four other α‐chain variants with a similar HPLC and IEF phenotype. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4401452 Thu, 27 Jan 2011 16:18:36 +0100 4401452 http://www.medworm.com/index.php?rid=4401454&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01291.x Conclusion:  These findings, when combined with the data on 35INS, support the concept that loss of the C‐terminus of BCR‐ABL1 is associated with significant resistance to kinase inhibitors; this mechanism appears to be a major source of resistance to kinase inhibitors. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4401454 Wed, 26 Jan 2011 00:00:00 +0100 4401454 http://www.medworm.com/index.php?rid=4401453&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01294.x Conclusion:  The Celltac F shows broadly comparable analytical performance to the XE‐2100 for the parameters assessed. The Celltac F is recommendable for medium‐sized laboratories or as a back‐up instrument in larger laboratories. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4401453 Wed, 26 Jan 2011 00:00:00 +0100 4401453 http://www.medworm.com/index.php?rid=4373798&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01295.x Conclusion:  Patients with two out of three features, GPC, antithyroid antibodies, gastric atrophy, but without HP organisms; or three features with HP organisms, can be predicted to have PA. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4373798 Thu, 20 Jan 2011 16:12:48 +0100 4373798 http://www.medworm.com/index.php?rid=4332823&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01288.x Conclusions:  These results suggest that CIP2A is over‐expressed in patients with newly diagnosed/relapsed AML and the expression of CIP2A could have potential use as a clinical marker for AML relapse after treatment. The high expression of CIP2A in HL60 cells may be related to active cell proliferation and arrest of cell differentiation. This study may shed light on the molecular function of CIP2A in myeloid leukemogenesis. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4332823 Wed, 12 Jan 2011 16:40:48 +0100 4332823 http://www.medworm.com/index.php?rid=4332825&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01286.x Conclusion:  If ASA resistance is detected by laboratory tests, replacement of ASA or its combination with other antiplatelet drugs as well as increased dosage may be considered. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4332825 Tue, 11 Jan 2011 00:00:00 +0100 4332825 http://www.medworm.com/index.php?rid=4332824&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01287.x Conclusion:  Beta globin deletion/duplication analysis is necessary to correctly identify the genotype in some patients being evaluated for beta thalassemia. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4332824 Tue, 11 Jan 2011 00:00:00 +0100 4332824 http://www.medworm.com/index.php?rid=4327759&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01293.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4327759 Mon, 10 Jan 2011 15:06:18 +0100 4327759 http://www.medworm.com/index.php?rid=4327758&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01226.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4327758 Mon, 10 Jan 2011 15:06:14 +0100 4327758 http://www.medworm.com/index.php?rid=4296766&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01285.x Conclusion:  T‐MSCs exhibited normal phenotype, karyotype as well as normal immunomodulatory function, and autologous MSCs from patients with thalassemia syndrome may be an attractive source of stem cell in terms of hematopoietic support as well as immunomodulatory activity. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4296766 Wed, 29 Dec 2010 00:00:00 +0100 4296766 http://www.medworm.com/index.php?rid=4246774&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01284.x Discussion:  Our findings suggest aCGH is an effective technique for evaluating recurring genetic abnormalities in CLL and improves on standard FISH in detecting genetic abnormalities in CLL. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4246774 Thu, 09 Dec 2010 00:00:00 +0100 4246774 http://www.medworm.com/index.php?rid=4221524&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01281.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4221524 Wed, 01 Dec 2010 00:00:00 +0100 4221524 http://www.medworm.com/index.php?rid=4215692&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01280.x Conclusion:  In our study group, a bone marrow biopsy was a useful investigation with a high diagnostic yield. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215692 Wed, 01 Dec 2010 00:00:00 +0100 4215692 http://www.medworm.com/index.php?rid=4215691&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01275.x Conclusion:  Routine testing for JAK2V617F is not currently recommended for patients with unexplained thromboses, except for those with splanchnic vein thrombosis. In patients with cerebral vein thrombosis, the value of testing for JAK2V617F mutation is yet to be established. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215691 Wed, 01 Dec 2010 00:00:00 +0100 4215691 http://www.medworm.com/index.php?rid=4215690&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01276.x Conclusion:  Our data strongly support the use of IgG‐only assays for the detection of HIT antibodies. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215690 Wed, 01 Dec 2010 00:00:00 +0100 4215690 http://www.medworm.com/index.php?rid=4215689&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01277.x Conclusion:  Thus, unlike Westergren erythrocyte sedimentation rate, sedimentation data obtained by the proposed method do not require correction for Hct. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215689 Wed, 01 Dec 2010 00:00:00 +0100 4215689 http://www.medworm.com/index.php?rid=4215688&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01279.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215688 Wed, 01 Dec 2010 00:00:00 +0100 4215688 http://www.medworm.com/index.php?rid=4215687&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01278.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215687 Wed, 01 Dec 2010 00:00:00 +0100 4215687 http://www.medworm.com/index.php?rid=4215686&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01281.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215686 Wed, 01 Dec 2010 00:00:00 +0100 4215686 http://www.medworm.com/index.php?rid=4215685&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01282.x Conclusion:  This combination of problems effectively combines to render selective reamplification and redigestion unsuitable for detecting low fractions of the V617F mutation. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215685 Wed, 01 Dec 2010 00:00:00 +0100 4215685 http://www.medworm.com/index.php?rid=4215684&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01283.x Conclusion:  Two reagents, namely aPTT‐SP and SynthASIL both of which are based on synthetic phospholipids and silica, were identified as promising candidates for incorporation into point‐of‐care diagnostic device platforms as dried reagents. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4215684 Wed, 01 Dec 2010 00:00:00 +0100 4215684 http://www.medworm.com/index.php?rid=4135979&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01273.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4135979 Fri, 05 Nov 2010 19:55:49 +0100 4135979 http://www.medworm.com/index.php?rid=4135980&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01272.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4135980 Thu, 04 Nov 2010 00:00:00 +0100 4135980 http://www.medworm.com/index.php?rid=4135983&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01269.x SummaryLaboratory identification of cytoplasmic inclusions in leucocytes as unusual manifestation of cryoglobulinemia has been previously reported (Maitra et al., 2000 American Journal of Clinical Pathology, 113, 107–112; Fohlen‐Walter et al., 2002American Journal of Clinical Pathology, 117, 606–614.). We would like to add two observations highlighting the following: (i) the peculiar picture of cryoglobulins in neutrophils and monocytes but sparing other white blood cell (WBC) and (ii) possibility of deposit occurrence with morphological identification in body fluids. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4135983 Wed, 03 Nov 2010 00:00:00 +0100 4135983 http://www.medworm.com/index.php?rid=4135982&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01270.x Conclusion:  Lesser amounts of EMA‐reactive membrane proteins were detected in HPP than HS red cells, thus confirming their lower fluorescence readings in the EMA‐binding test. The concomitant reduction in glycophorins A and C, and CD59 in HPP could have caused cellular contraction, resulting in poikilocytosis. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4135982 Wed, 03 Nov 2010 00:00:00 +0100 4135982 http://www.medworm.com/index.php?rid=4135981&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01268.x Conclusion:  Data from ongoing and future studies are awaited to better understand this entity and to highlight the most appropriate treatment strategies. (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4135981 Wed, 03 Nov 2010 00:00:00 +0100 4135981 http://www.medworm.com/index.php?rid=4110887&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01271.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4110887 Fri, 29 Oct 2010 18:22:23 +0100 4110887 http://www.medworm.com/index.php?rid=4041932&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01263.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4041932 Thu, 30 Sep 2010 23:00:00 +0100 4041932 http://www.medworm.com/index.php?rid=4033162&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01267.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4033162 Thu, 30 Sep 2010 23:00:00 +0100 4033162 http://www.medworm.com/index.php?rid=4014959&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01266.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4014959 Thu, 30 Sep 2010 14:53:53 +0100 4014959 http://www.medworm.com/index.php?rid=4006076&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01264.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4006076 Wed, 29 Sep 2010 14:24:12 +0100 4006076 http://www.medworm.com/index.php?rid=3995646&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01262.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3995646 Fri, 24 Sep 2010 08:11:24 +0100 3995646 http://www.medworm.com/index.php?rid=3966863&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01261.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3966863 Wed, 15 Sep 2010 06:15:21 +0100 3966863 http://www.medworm.com/index.php?rid=3917213&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01259.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3917213 Wed, 01 Sep 2010 06:25:47 +0100 3917213 http://www.medworm.com/index.php?rid=4006077&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01265.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=4006077 Tue, 31 Aug 2010 23:00:00 +0100 4006077 http://www.medworm.com/index.php?rid=3966864&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01260.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3966864 Tue, 31 Aug 2010 23:00:00 +0100 3966864 http://www.medworm.com/index.php?rid=3891048&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01217.x (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891048 Mon, 23 Aug 2010 06:22:32 +0100 3891048 http://www.medworm.com/index.php?rid=3891047&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2010.01220.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891047 Mon, 23 Aug 2010 06:22:32 +0100 3891047 http://www.medworm.com/index.php?rid=3891046&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01219.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891046 Mon, 23 Aug 2010 06:22:31 +0100 3891046 http://www.medworm.com/index.php?rid=3891045&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01218.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891045 Mon, 23 Aug 2010 06:22:31 +0100 3891045 http://www.medworm.com/index.php?rid=3891044&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01216.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891044 Mon, 23 Aug 2010 06:22:30 +0100 3891044 http://www.medworm.com/index.php?rid=3891043&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01215.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891043 Mon, 23 Aug 2010 06:22:30 +0100 3891043 http://www.medworm.com/index.php?rid=3891042&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01213.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891042 Mon, 23 Aug 2010 06:22:30 +0100 3891042 http://www.medworm.com/index.php?rid=3891041&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01212.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891041 Mon, 23 Aug 2010 06:22:29 +0100 3891041 http://www.medworm.com/index.php?rid=3891040&cid=s_29466_19_f&fid=29466&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1751-553X.2009.01211.x Summary (Source: Clinical and Laboratory Haematology) Clinical and Laboratory Haematology journals http://www.medworm.com/rss/comments.php?id=3891040 Mon, 23 Aug 2010 06:22:29 +0100 3891040