MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical and Molecular Allergy' source. Wed, 08 Feb 2012 06:42:48 +0100 http://www.medworm.com/index.php?rid=5666435&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F10%2F1%2F3 Conclusions: Our results showed that CSE significantly increased inflammatory cytokines IL-6 and IL-8 production in IL-1-activated HMC-1. It may partially explain why cigarette smoke contributes to lung and cardiovascular diseases. BAI inhibited the production of inflammatory cytokines through inhibition of NF-kappaB activation and IkappaBalpha phosphorylation and degradation. This inhibitory effect of BAI on the expression of inflammatory cytokines induced by CSE suggests its usefulness in the development of novel anti-inflammatory therapies. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5666435 Mon, 06 Feb 2012 05:00:00 +0100 5666435 http://www.medworm.com/index.php?rid=5666434&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F10%2F1%2F4 Conclusions: The correlation between nasal CC16 and nNO levels in patients with allergic rhinitis, along with an inverse relationship between their levels and the occurrences of MC in allergic inflammation, may indicate that both biomarkers have anti-inflammatory effects by suppression of cell recruitment. The mechanisms behind these observations warrant further analyses. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5666434 Mon, 06 Feb 2012 05:00:00 +0100 5666434 http://www.medworm.com/index.php?rid=5559152&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F10%2F1%2F2 ObjectiveThe phenomena manifested during inflammation require interplay between circulating effector cells, local resident cells, soluble mediators and genetic host factors to establish, develop and maintain itself. Of the molecues involed in the initiation and perpetuation of acute allergic inflammation in asthma, the involvement of effector cells in redox reactions for producing O2- (superoxide anion) through the mediation of NADPH oxidase is a critical step. Prior data suggest that reactive oxygen species (ROS) produced by NADPH oxidase homologues in non-phagocytic cells play an important role in the regulation of signal transduction, while macrophages use a membrane-associated NADPH oxidase to generate an array of oxidizing intermediates which inactivate MMPs on or near them.Materials ... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5559152 Wed, 04 Jan 2012 05:00:00 +0100 5559152 http://www.medworm.com/index.php?rid=5559153&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F10%2F1%2F1 Conclusions: High levels of casein-sIgE antibodies are strongly associated with milk allergy in children and might be associated with prolonged allergy. Elevated casein-sIgG4 levels in milk-sensitized individuals on normal diet indicate a modified Th2 response. However, the protective role of IgG4 antibodies in milk allergy is unclear. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5559153 Mon, 02 Jan 2012 05:00:00 +0100 5559153 http://www.medworm.com/index.php?rid=5456545&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F14 We report a young child ultimately presenting with disseminated histoplasmosis and a novel STAT3 variant in the SH2 domain. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5456545 Tue, 29 Nov 2011 05:00:00 +0100 5456545 http://www.medworm.com/index.php?rid=5440049&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F13 Chronic Granulomatous Disease (CGD), a disorder of the NADPH oxidase system, results in phagocyte functional defects and subsequent infections with bacterial and fungal pathogens (such as Aspergillus species and Candida albicans). Deletions and missense, frameshift, or nonsense mutations in the gp91phox gene (also termed CYBB), located in the Xp21.1 region of the X chromosome, are associated with the most common form of CGD. When larger X-chromosomal deletions occur, including the XK gene deletion, a so-called "Contiguous Gene Deletion Syndrome" may result. The contiguous gene deletion syndrome is known to associate the Kell phenotype/McLeod syndrome with diseases such as X-linked chronic granulomatous disease, Duchenne muscular dystrophy, and X-linked retinitis pigmentosa. These patients ... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5440049 Wed, 23 Nov 2011 05:00:00 +0100 5440049 http://www.medworm.com/index.php?rid=5272877&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F12 Conclusions: We observed significant changes in gene expression early in peripheral blood samples from allergic patients undergoing RIT. Moreover, serum levels for allergen specific IgG4 also increased over the course of treatment. These studies suggest that RIT induces rapid and dynamic alterations in both innate and adaptive immunity which can be observed in the periphery of allergic patients. These alterations could be directly related to the therapeutic shift in the allergen-specific class of immunoglobulin. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5272877 Fri, 30 Sep 2011 04:00:00 +0100 5272877 http://www.medworm.com/index.php?rid=5063019&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F11 ${item.shortDescription} (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=5063019 Mon, 25 Jul 2011 23:00:00 +0100 5063019 http://www.medworm.com/index.php?rid=4884291&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F10 Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. The disease is the result of a disorder of the NADPH oxidase system, culminating in an inability of the phagocyte to generate superoxide, leading to the defective killing of pathogenic organisms. This can lead to infections with Staphylococcus aureus, Psedomonas species, Nocardia species, and fungi (such as Aspergillus species and Candida albicans). Involvement of vital or large organs can contribute to morbidity and/or mortality in the affected patients. Major advances have occurred in the diagnosis and treatment of this disease, with the potential for gene... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4884291 Mon, 30 May 2011 23:00:00 +0100 4884291 http://www.medworm.com/index.php?rid=4872828&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F9 Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Pathologically, it can be considered a form of immune complex-mediated leukocytoclastic vasculitis involving the skin and other organs. Though it primarily affects children (over 90% of cases), the occurrence in adults has been rarely reported. Management often involves the use of immunomodulatory or immune-suppressive regimens. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4872828 Thu, 26 May 2011 23:00:00 +0100 4872828 http://www.medworm.com/index.php?rid=4842334&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F8 Background: Objective markers of early airway inflammation in infants are not established but are of great interest in a scientific setting. Exhaled nitric oxide (FeNO) and urinary eosinophilic protein X (uEPX) are a two such interesting markers.ObjectiveTo investigate the feasibility of measuring FeNO and uEPX in infants and their mothers and to determine if any relations between these two variables and environmental factors can be seen in a small sample size. This was conducted as a pilot study for the ongoing Swedish Environmental Longitudinal Mother and child Asthma and allergy study (SELMA). Methods: Consecutive infants between two and six months old and their mothers at children's health care centres were invited, and 110 mother-infant pairs participated. FeNO and uEPX were analysed ... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4842334 Sun, 15 May 2011 23:00:00 +0100 4842334 http://www.medworm.com/index.php?rid=4693658&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F6 The field of primary immunodeficiencies (PIDs) is one of several in the area of clinical immunology that has not been static, but rather has shown exponential growth due to enhanced physician, scientist and patient education and awareness, leading to identification of new diseases, new molecular diagnoses of existing clinical phenotypes, broadening of the spectrum of clinical and phenotypic presentations associated with a single or related gene defects, increased bioinformatics resources, and utilization of advanced diagnostic technology and methodology for disease diagnosis and management resulting in improved outcomes and survival. There are currently over 200 PIDs with at least 170 associated genetic defects identified, with several of these being reported in recent years. The enormous ... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4693658 Fri, 08 Apr 2011 23:00:00 +0100 4693658 http://www.medworm.com/index.php?rid=4532144&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F5 Conclusions: This is the first survey to assess the impact on patient-reported outcomes of a mandated switch from prescription to generic antihistamines in Norway. The findings suggest that patient response to different antihistamines will vary and that treatment decisions should be individualized for optimal results. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4532144 Mon, 28 Feb 2011 00:00:00 +0100 4532144 http://www.medworm.com/index.php?rid=4451018&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F4 Conclusions: These results suggest that ALBE inhibits the expression of IL-4 and IL-5 by downregulating MAPKs and NF-kappaB activation in ConA-treated splenocytes and supports the hypothesis that ALBE may have beneficial effects in the treatment of allergic diseases, including atopic dermatitis. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4451018 Tue, 08 Feb 2011 00:00:00 +0100 4451018 http://www.medworm.com/index.php?rid=4378312&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F3 Conclusions: Systemically activated eosinophils and neutrophils have similar patterns of degranulation after allergen exposure in allergic rhinitis and allergic asthma. The released amount of ECP, EPO and MPO was similar in all allergen challenge models in both allergic groups. Our results indicate that other mechanisms than the magnitude of eosinophil and neutrophil inflammation or the degranulation pattern of the inflammatory cells determines whether or not an allergic patient develops asthma. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4378312 Fri, 21 Jan 2011 00:00:00 +0100 4378312 http://www.medworm.com/index.php?rid=4362034&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F2 We present here a study that demonstrates the effectiveness of omalizumab in treating this condition and the temporal relationship between improvement and down regulation of the high affinity IgE receptor (FcERI). For this, blood samples were obtained from a symptomatic patient before each treatment and processed for flow cytometric analysis of FcERI levels on the surface of blood basophils. Down regulation of FcERI was observed in association with significant clinical improvement and discontinuation of immunosuppressive medications. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4362034 Wed, 19 Jan 2011 00:00:00 +0100 4362034 http://www.medworm.com/index.php?rid=4362035&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F9%2F1%2F1 Conclusions: TSLP SNP rs1837253 is associated with reduced odds for AR in boys with asthma. Our findings support a role for TSLP in the pathogenesis of AR in children with asthma. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4362035 Tue, 18 Jan 2011 00:00:00 +0100 4362035 http://www.medworm.com/index.php?rid=4175614&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F16 We present here the predictive value of skin prick testing for the presence of allergen-specific IgE, in 12 patients, determined by immunoblot against the allergen extracts using individual-matched serum. Our results demonstrate a high degree of predictive value for aeroallergens but a poor predictive value for food allergens. This suggests that skin prick testing likely identifies IgE reactivity towards aeroallergens in adult eosinophilic esophagitis but this is not true for foods. Consequently, IgE immunoblotting might be required for determining food avoidance in these patients. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4175614 Wed, 17 Nov 2010 00:00:00 +0100 4175614 http://www.medworm.com/index.php?rid=4126343&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F15 Conclusions: Remarkable coordination of allergen gene expression in response to a specific condition (oxidative stress or the presence of cAMP) has been observed, implying that a single biological stimulus may play a role in allergen gene regulation. Interdiction of a putative allergen expression induction signalling pathway might provide a novel therapy for treatment of fungal allergy. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4126343 Wed, 03 Nov 2010 00:00:00 +0100 4126343 http://www.medworm.com/index.php?rid=4126344&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F14 Conclusions: Our results indicate modifying influence of histamine N-methyltransferase functional polymorphism on the risk of asthma. The other HNMT polymorphisms and ABP1 functional polymorphism seem unlikely to affect the risk of asthma. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=4126344 Mon, 01 Nov 2010 00:00:00 +0100 4126344 http://www.medworm.com/index.php?rid=3977656&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F13 Conclusions: These results rule out a possible role of protein kinase C in the complex response of basophil to quercetin, while indirectly suggest PI3K as the major intracellular target of this compound also in human basophils. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3977656 Thu, 16 Sep 2010 23:00:00 +0100 3977656 http://www.medworm.com/index.php?rid=3849918&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F12 Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN). Here, we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old patient with insulin allergy. Insulin aspart & insulin aspart 30 mix were given to the patient and an elevation of the eosinophil count (8440/ul, 17.6 fold) and a moderate increase of IgE (501U/ml, reference range: 10-350U/ml), eotaxin-3 (168pg/ml, 2 fold), histamine (0.95ng/ml, 5.3 fold) were found 33 days later. The plasma levels of GAL-9 and OPN were 22.5 and 1.7 fold higher than the cut-off point, respectively. After one month cessation of insulin therapy, elevations of the eosinophil count (3,... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3849918 Tue, 10 Aug 2010 23:00:00 +0100 3849918 http://www.medworm.com/index.php?rid=3817875&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F11 Background: Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However, the association of allergen-induced cord blood mononuclear cell (CBMC) proliferation and cytokine production with later allergic immune responses and asthma has been controversial. Our objective was to compare indoor allergen-induced CBMC with age 5 peripheral blood mononuclear cell (PBMC) proliferation and determine which may be associated with age 5 allergic immune responses and asthma in an inner city cohort. Methods: As part of an ongoing cohort study of the Columbia Center for Children's Environmental Health (CCCEH), CBMCs and age 5 PBMCs were cultured with cockroach, mouse, and dust mite protein extracts. CBMC proliferation and... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3817875 Tue, 03 Aug 2010 23:00:00 +0100 3817875 http://www.medworm.com/index.php?rid=3765045&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F10 Conclusion: Eosinophils respond to hypoxia by up-regulation of survival and of some of their pro-angiogenic functions indicating a correlation between eosinophilic inflammation and angiogenesis. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3765045 Sun, 18 Jul 2010 23:00:00 +0100 3765045 http://www.medworm.com/index.php?rid=3747546&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F9 Conclusions: FcRn expression was a major factor in determining how breastfed offspring of allergic mothers acquired levels of systemic allergen-specific IgG1 sufficient to inhibit allergic sensitization in this model. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3747546 Mon, 12 Jul 2010 23:00:00 +0100 3747546 http://www.medworm.com/index.php?rid=3711538&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F8 Background: Atopic dermatitis (AD) is often the prelude to allergic diseases. The aim of this study was 1) to evaluate if an integrated management regime could bring about a change in the evolution of the disease in comparison to the results of a previous study; 2) to determine whether the refinement of allergic investigations allowed to identify more promptly the risk factors of evolution into respiratory allergic diseases. Methods: The study included 176 children affected by AD and previously evaluated between 1993 and 2002 at the age of 9-16 months, who underwent a telephonic interview by means of a semi-structured, pre-formed questionnaire after a mean follow-up time of 8 years. According to the SCORAD, at first evaluation children had mild AD in 23% of cases, moderate in 62%, severe i... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3711538 Tue, 29 Jun 2010 23:00:00 +0100 3711538 http://www.medworm.com/index.php?rid=3430223&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F7 Conclusions: The recombinant availability of Ves v 1 from yellow jacket venom will contribute to a more detailed understanding of the molecular and allergological mechanisms of insect venoms and may provide a valuable tool for diagnostic and therapeutic approaches in hymenoptera venom allergy. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3430223 Wed, 31 Mar 2010 23:00:00 +0100 3430223 http://www.medworm.com/index.php?rid=3487845&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F6 We describe 6 patients presenting with recurrent inflammatory and/or infectious skin conditions who also demonstrated severely low MBL levels. One patient also had a defect in the MASP2 gene. Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient. Five patients presented recurrent pustular skin infections (cellulitis, folliculitis and cutaneous abscess). A case of Grover's disease and one forme fruste of Behcet's syndrome (orogenital ulcers) were also observed. The patients responded to antimicrobial therapy, although in some, recurrence of infection was the rule. It appears that MBL deficiency may contribute to recurrent skin infections and to certain forms of inflammatory skin disease. The mechanisms may relate ... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3487845 Thu, 25 Mar 2010 00:00:00 +0100 3487845 http://www.medworm.com/index.php?rid=3404951&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F6 We describe 6 patients presenting with recurrent inflammatory and/or infectious skin conditions who also demonstrated severely low MBL levels. One patient also had a defect in the MASP2 gene. Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient. Five patients presented recurrent pustular skin infections (cellulitis, folliculitis and cutaneous abscess). A case of Grovers disease and one forme fruste of Behcet's syndrome (orogenital ulcers) were also observed. The patients responded to antimicrobial therapy, although in some, recurrence of infection was the rule. It appears that MBL deficiency may contribute to recurrent skin infections and to certain forms of inflammatory skin disease. The mechanisms may relate... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3404951 Thu, 25 Mar 2010 00:00:00 +0100 3404951 http://www.medworm.com/index.php?rid=3379861&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F5 We examined HLA-DR and HLA-DQ frequencies in Alternaria-sensitive asthmatic by HLA typing. To determine ratios of Th1/Th2 Alternaria-specific T-cells, cultures were stimulated in media alone, Alternaria alternata extract and Alt a1. Sensitivity to IL-4 stimulation was measured by up-regulation of CD23 on B cells. Results: Children with Alternaria-sensitive moderate-severe asthma trended to have increased sensitivities to Cladosporium (46% versus 35%), to Aspergillus (43% versus 28%), and significantly increased sensitivities to trees (78% versus 57%) and to weeds (68% versus 48%). The IL-4RA ile75val polymorphism was significantly increased in Alternaria-sensitive moderate-severe asthmatics, 83% (0.627 allele frequency) compared to Alternaria-sensitive mild asthmatics, 57% (0.388 allele fr... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3379861 Thu, 18 Mar 2010 00:00:00 +0100 3379861 http://www.medworm.com/index.php?rid=3366816&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F4 Conclusions Patients did not show neo-sensitization to tropomyosin, a component of the extract (namely mite group 10) administered. An assessment of a patient's possible pre-existing sensitisation to tropomyosin by skin test and/or specific IgE prior to start mite extract immunotherapy is recommended. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3366816 Mon, 15 Mar 2010 00:00:00 +0100 3366816 http://www.medworm.com/index.php?rid=3468827&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F3 Conclusion: Evaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3468827 Tue, 23 Feb 2010 00:00:00 +0100 3468827 http://www.medworm.com/index.php?rid=3299371&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F3 Conclusion: Evaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3299371 Tue, 23 Feb 2010 00:00:00 +0100 3299371 http://www.medworm.com/index.php?rid=3276977&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F2 Background: Subcutaneous Immunotherapy (SCIT) modifies the allergic response and relieves allergic symptoms. SCIT is the only and a very effective treatment for insect venom allergy. We hypothesized that basophil sensitivity, measured through the basophil activation test, would decrease during SCIT up dosing. Expression of CD203c was compared to CD63 as marker for basophil activation, using a Bland Altman plot and ROC curves. Methods: Patients (n=18) starting subcutaneous SCIT for wasp allergy with an up dosing scheme of 7 to 11 weeks were enrolled. Heparinised blood samples were drawn at weeks 1-4, 7 and at the first maintenance visit. Basophils were stimulated with 7 log dilutions of V. vespula allergen for 15 min, and were stained with CD203c and CD63. Basophils were identified as CD203... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3276977 Tue, 16 Feb 2010 00:00:00 +0100 3276977 http://www.medworm.com/index.php?rid=3232594&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F8%2F1%2F1 Rhinitis is characterized by rhinorrhea, sneezing, nasal congestion, nasal itch and/or postnasal drip. Often the first step in arriving at a diagnosis is to exclude or diagnose sensitivity to inhalant allergens. Non-allergic rhinitis (NAR) comprises multiple distinct conditions that may even co-exist with allergic rhinitis (AR). They may differ in their presentation and treatment. As well, the pathogenesis of NAR is not clearly elucidated and likely varied. There are many conditions that can have similar presentations to NAR or AR, including nasal polyps, anatomical/mechanical factors, autoimmune diseases, metabolic conditions, genetic conditions and immunodeficiency. Here we present a case of a rare condition initially diagnosed and treated as typical allergic rhinitis vs. vasomotor rhini... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3232594 Wed, 03 Feb 2010 00:00:00 +0100 3232594 http://www.medworm.com/index.php?rid=3023799&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F10 We present the first case of a child suffering anaphylaxis produced by ingestion of contaminated flour with Thyreophagus entomophagus. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=3023799 Wed, 25 Nov 2009 00:00:00 +0100 3023799 http://www.medworm.com/index.php?rid=2940586&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F9 The use of biotechnological techniques to introduce novel proteins into food crops (transgenic or GM crops) has motivated investigation into the properties of proteins that favor their potential to elicit allergic reactions. As part of the allergenicity assessment, bioinformatic approaches are used to compare the amino-acid sequence of candidate proteins with sequences in a database of known allergens to predict potential cross reactivity between novel food proteins and proteins to which people have become sensitized. Two criteria commonly used for these queries are searches over 80-amino-acid stretches for >35% identity, and searches for 8-amino-acid contiguous matches. We investigated the added value provided by the 8-amino-acid criterion over that provided by the >35%-identity-over-80-a... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2940586 Thu, 29 Oct 2009 00:00:00 +0100 2940586 http://www.medworm.com/index.php?rid=2581663&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F8 Conclusions: U.S. urban newborns have Treg cells that express Foxp3, albeit with an immature phenotype and function as compared to the mothers. Longitudinal follow-up is needed to delineate Treg cell maturation and subsequent risk for atopic diseases in this urban birth cohort. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2581663 Tue, 07 Jul 2009 23:00:00 +0100 2581663 http://www.medworm.com/index.php?rid=2390591&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F7 Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized societies it is also referred to as "disease of civilizations". Due to its increased prevalence among related individuals, it was understood quite long back that it is a genetic disorder. Well designed epidemiological studies reinforced these views.The advent of modern biological technology saw further refinements in our understanding of genetics of asthma and led to the realization that asthma is not a disorder with simple Mendelian mode of inheritance but a multifactorial disorder of the airways brought about by complex interaction between genetic and environmental factors. Current a... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2390591 Wed, 06 May 2009 04:00:00 +0100 2390591 http://www.medworm.com/index.php?rid=2390592&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F6 Conclusions: This particular AbM extract may both prevent allergy development and be used as a therapeutical substance against established allergy. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2390592 Tue, 05 May 2009 04:00:00 +0100 2390592 http://www.medworm.com/index.php?rid=2262237&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F5 Dysregulated immune response results in inflammatory symptoms in the respiratory mucosa leading to asthma and allergy in susceptible individuals. The T helper type 2 (Th2) subsets are primarily involved in this disease process. Nevertheless, there is growing evidence in support of T cells with regulatory potential that operates in non-allergic individuals. These regulatory T cells occur naturally are called natural T regulatory cells (nTregs) and express the transcription factor Foxp3. They are selected in the thymus and move to the periphery. The CD4 Th cells in the periphery can be induced to become regulatory T cells and hence called induced or adaptive T regulatory cells. These cells can make IL-10 or TGF-b or both, by which they attain most of their suppressive activity. This review g... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2262237 Thu, 12 Mar 2009 04:00:00 +0100 2262237 http://www.medworm.com/index.php?rid=2203520&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F4 Though not widely recognized, food hypersensitivity by inhalation can cause major morbidity in affected individuals. The exposure is usually more obvious and often substantial in occupational environments but frequently occurs in non-occupational settings, such as homes, schools, restaurants, grocery stores, and commercial flights. The exposure can be trivial, as in mere smelling or being in the vicinity of the food. The clinical manifestations can vary from a benign respiratory or cutaneous reaction to a systemic one that can be life-threatening. In addition to strict avoidance, such highly-sensitive subjects should carry self-injectable epinephrine and wear MedicAlert(R) identification. Asthma is a strong predisposing factor and should be well-controlled. It is of great significance that... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2203520 Fri, 20 Feb 2009 05:00:00 +0100 2203520 http://www.medworm.com/index.php?rid=2151933&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F3 This study describes the localization of the human IgE-binding regions of the major group 1 pollen allergen Cyn d 1 from Bermuda grass. Methods: A cDNA library was constructed from Bermuda grass pollen (BGP) using a Lambda gt11 expression vector. The gene encoding the Cyn d 1 allergen was isolated by screening the library with a mouse monoclonal antibody raised against grass group 1 allergen. In order to characterize the IgE epitopes on Cyn d 1, seven overlapping fragments and three deletion mutants were cloned and over-expressed in E. coli. The recombinant fragments and deletion mutants were evaluated for their comparative IgE reactivity with sera of normal and grass pollen allergic patients by ELISA and a dot-blot assay. Results: Analysis of IgE binding regions by overlapping fragments ... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2151933 Mon, 02 Feb 2009 05:00:00 +0100 2151933 http://www.medworm.com/index.php?rid=2118892&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F2 Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition, recent evidence strongly suggests that viral infections may also have a causal role in the development of childhood asthma. In this article, we will briefly describe the general perception of how the link between infections and asthma has changed over the last century, and then focus on very recent developments that have provided new insights into the contribution of viruses to asthma pathogenesis. Highlighted areas include the contribution of severe early life viral infections to asthma inception, genetic determinants of severe viral infections in infancy, the differences in innate and adaptive immune system cytokine responses to viral infection between asthmatic and nonasthmatic subj... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2118892 Tue, 20 Jan 2009 05:00:00 +0100 2118892 http://www.medworm.com/index.php?rid=2106462&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F7%2F1%2F1 Food allergies affect an estimated 3 to 4% of adults and up to 8% of children in developed western countries. Results from in vitro simulated gastric digestion studies with purified proteins are routinely used to assess the allergenic potential of novel food proteins. The digestion of purified proteins in simulated gastric fluid typically progresses in an exponential fashion allowing persistence to be quantified using pseudo-first-order rate constants or half lives. However, the persistence of purified proteins in simulated gastric fluid is a poor predictor of the allergenic status of food proteins, potentially due to food matrix effects that can be significant in vivo. The evaluation of the persistence of novel proteins in whole, prepared food exposed to simulated gastric fluid may provid... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2106462 Thu, 15 Jan 2009 05:00:00 +0100 2106462 http://www.medworm.com/index.php?rid=2015198&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F13 We report a case of IgE-mediated anaphylaxis to seminal plasma that was diagnosed by skin prick tests and successfully treated by local desensitization. 32-year-old woman suffering from angioedema and hypotension after exposure to semen was treated with epinephrine upon admission. Skin prick tests and immunoblotting for IgE binding components showed that she was sensitized to her husband's seminal plasma. Local desensitization, which persisted for six months, was achieved by intravaginal administration of serial dilutions of her husband's seminal plasma. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=2015198 Fri, 05 Dec 2008 05:00:00 +0100 2015198 http://www.medworm.com/index.php?rid=1882423&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F12 Conclusions: Use of polychromatic flow cytometry allowed efficient basophil electronic purification and identification of different behaviors of the major activation markers. The simultaneous use of two markers of activation and careful choice of activator are essential steps for reliable assessment of human basophil functions. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1882423 Thu, 16 Oct 2008 04:00:00 +0100 1882423 http://www.medworm.com/index.php?rid=1814291&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F11 Conclusion: Our findings suggest that reduced microbial diversity is associated with the development of eczema in early life. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1814291 Mon, 22 Sep 2008 04:00:00 +0100 1814291 http://www.medworm.com/index.php?rid=1801617&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F10 Conclusions: According to the results of this experiment we concluded that immunotherapy via the I.N co-administration of CpG/Ch.a in comparison with S.C route is more effective to stimulate the mucosal and regulatory responses in Ch.a induced asthma. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1801617 Wed, 17 Sep 2008 04:00:00 +0100 1801617 http://www.medworm.com/index.php?rid=1793219&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F9 Conclusions: During the initiation of allergy, the N- and/or C-terminal ends of proteolytic processing intermediates were preferentially loaded into antigen presenting proteins for the priming of CD4+ T cells. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1793219 Mon, 15 Sep 2008 04:00:00 +0100 1793219 http://www.medworm.com/index.php?rid=1767463&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F8 We present a clinical and molecular review of the Hoover's sign and explain how it could be utilized in the bedside and emergent management of airway disease. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1767463 Fri, 05 Sep 2008 04:00:00 +0100 1767463 http://www.medworm.com/index.php?rid=1670207&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F6 Background: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. Methods: We tested for association between four linkage disequilibrium (LD)-tagging SNPs (rs2243123, rs2243151, rs668998, and rs17826053) in IL12A and asthma and allergy-related (serum total and allergen-specific IgE, and skin test reactivity [STR] to two common allergens) phenotypes in two samples: 417 Costa Rican children with asthma and their parents, and 470 families of 503 white children in the Childhood Asthma Management Program (CAMP). The analysis was conducted using the family-based association test (FBAT) statistic implemented in the PBAT program. Results: Among Costa Rican children with asthma, homozygosity for the minor allele of each of two SNPs i... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1670207 Thu, 31 Jul 2008 04:00:00 +0100 1670207 http://www.medworm.com/index.php?rid=1486052&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F5 Background: Common variable immune deficiency (CVID), one of the most common primary immunodeficiency diseases presents in adults, whereas X-linked agammaglobulinemia (XLA), an inherited humoral immunodeficiency, is usually diagnosed early in life after maternal Igs have waned. However, there have been several reports in the world literature in which individuals have either had a delay in onset of symptoms or have been misdiagnosed with CVID and then later found to have mutations in Bruton's tyrosine kinase (BTK) yielding a reclassification as adult-onset variants of XLA. The typical finding of absent B cells should suggest XLA rather than CVID and may be a sensitive test to detect this condition, leading to the more specific test (Btk mutational analysis). Further confirmation may be by m... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1486052 Mon, 02 Jun 2008 04:00:00 +0100 1486052 http://www.medworm.com/index.php?rid=1452909&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F4 Atopic diseases and asthma are increasing at a remarkable rate on a global scale. It is now well recognized that asthma is a chronic inflammatory disease of the airways. The inflammatory process in many patients is driven by an immunoglobulin E (IgE)-dependent process. Mast cell activation and release of mediators, in response to allergen and IgE, result in a cascade response, culminating in B lymphocyte, T lymphocyte, eosinophil, fibroblast, smooth muscle cell, and endothelial activation. This complex cellular interaction, release of cytokines, chemokines and growth factors and inflammatory remodeling of the airways leads to chronic asthma. A subset of patients develops severe airway disease which can be extremely morbid and even fatal. While many treatments are available for asthma, it i... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1452909 Tue, 20 May 2008 04:00:00 +0100 1452909 http://www.medworm.com/index.php?rid=1398378&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F3 In Asian countries where the Buddhism and Taoism are mainstream religions, incense burning is a daily practice. A typical composition of stick incense consists of 21% (by weight) of herbal and wood powder, 35% of fragrance material, 11% of adhesive powder, and 33% of bamboo stick. Incense smoke (fumes) contains particulate matter (PM), gas products and other organic compounds. On average, incense burning produces particulates greater than 45 mg/g burned (as compared to 10 mg/g burned for cigarettes). The gas products from burning incense include CO, CO2, NO2, SO2, and others. Incense burning also produces volatile organic compounds, such as benzene, toluene, and xylenes, as well as aldehydes and polycyclic aromatic hydrocarbons (PAHs). The air pollution in and around various temples has be... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1398378 Fri, 25 Apr 2008 04:00:00 +0100 1398378 http://www.medworm.com/index.php?rid=1370209&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F2 Hereditary angioedema is a serious medical condition caused by a deficiency of C1-inhibitor. The condition is the result of a defect in the gene controlling the synthesis of C1-inhibitor, which regulates the activity of a number of plasma cascade systems. Although the prevalence of hereditary angioedema is low - between 1:10,000 to 1:50,000 - the condition can result in considerable pain, debilitation, reduced quality of life, and even death in those afflicted. Hereditary angioedema presents clinically as cutaneous swelling of the extremities, face, genitals, and trunk, or painful swelling of the gastrointestinal mucosa. Angioedema of the upper airways is extremely serious and has resulted in death by asphyxiation. Subnormal levels of C1-inhibitor are associated with the inappropriate act... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1370209 Mon, 14 Apr 2008 04:00:00 +0100 1370209 http://www.medworm.com/index.php?rid=1138672&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F6%2F1%2F1 The objective of the study was to assess the potential diagnostic of freeze-dried extracts of Canary Islands tomatoes, comparing the wheal sizes induced by prick test with the prick-prick method. Methods: Two groups of patients were analyzed: Group I: 26 individuals reporting clinical symptoms induced by tomato contact or ingestion. Group II: 71 control individuals with no symptoms induced by tomato: 12 of them were previously skin prick test positive to a tomato extract, 39 were atopic and 20 were non-atopic. All individuals underwent prick-prick with fresh ripe peel Canary tomatoes and skin prick tested with freeze-dried peel and pulp extracts obtained from peel and pulp of Canary tomatoes at 10 mg/ml. Wheal sizes and prick test positivity (7 mm2) were compared between groups. Results: I... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1138672 Wed, 09 Jan 2008 05:00:00 +0100 1138672 http://www.medworm.com/index.php?rid=1050524&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F5%2F1%2F5 Conclusions: Our results showed that BAI inhibited the production of inflammatory cytokines through inhibition of NF-kapaB activation and IkapaBalpha phosphorylation and degradation in human mast cells. This inhibitory effect of BAI on the expression of inflammatory cytokines suggests its usefulness in the development of novel anti-inflammatory therapies. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=1050524 Mon, 26 Nov 2007 05:00:00 +0100 1050524 http://www.medworm.com/index.php?rid=987780&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F5%2F1%2F4 Conclusion: Our study indicates that patients with allergic asthma and allergic rhinitis have the same degree of eosinophil inflammation. Despite this, only the asthmatic group experienced an impairment in lung function during the pollen season. This indicated that factors other than the eosinophil inflammation determine whether or not allergic patients develop asthma. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=987780 Mon, 29 Oct 2007 04:00:00 +0100 987780 http://www.medworm.com/index.php?rid=712209&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F5%2F1%2F3 While biotechnology-derived allergen therapeutics show promise in improving the safety of immunotherapy, they may prove to have additional benefits in comparison to conventional allergenic extracts that deserve commentary. These issues range from product stability and compatibility to medical practice issues, which will be the focus of this article. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=712209 Wed, 04 Jul 2007 04:00:00 +0100 712209 http://www.medworm.com/index.php?rid=407912&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F5%2F1%2F2 The prediction of allergen cross-reactivity is currently largely based on linear sequence data, but will soon include 3D information on homology among surface exposed residues. To evaluate procedures for these predictions, we need ways to quantitatively assess actual cross-reactivity between two allergens. Three parameters are mentioned: 1) the fraction of the epitopes that is cross-reactive; 2) the fraction of IgE that is cross-reactive; 3) the relative affinity of the interaction between IgE and the two allergens. This editorial briefly compares direct binding protocols with the often more appropriate reciprocal inhibition protocols. The latter type of protocol provides information on symmetric versus asymmetric cross-reactivity, and thus on the distinction between complete (=sensitising... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=407912 Fri, 09 Feb 2007 07:00:00 +0100 407912 http://www.medworm.com/index.php?rid=383123&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F5%2F1%2F1 Conclusions: These results suggest that curcumin has potential therapeutic value for controlling allergic responses resulting from exposure to allergens. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=383123 Thu, 25 Jan 2007 07:00:00 +0100 383123 http://www.medworm.com/index.php?rid=207046&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F13 Conclusion: Cesarean section is associated with increased levels of IL-13 and IFN-gamma, perhaps because of lack of labor and/or reduced exposure to specific microbes (e.g., gram-positive anaerobes) at birth. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=207046 Tue, 26 Sep 2006 06:00:00 +0100 207046 http://www.medworm.com/index.php?rid=202504&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F12 Conclusions: Four putative Beauveria bassiana allergens were identified. Recombinant proteins corresponding to two of the four, Bb-Eno1 and Bb-Ald were bound by sera IgEs derived from patients with fungal allergies. These data confirm the potential allergenicity of B. bassiana by identification of specific human IgE reactive epitopes. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=202504 Fri, 22 Sep 2006 06:00:00 +0100 202504 http://www.medworm.com/index.php?rid=129596&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F11 Conclusion: When results of several allergens such as Asp f 1, f 2, f 3, f 4, and f 6 in their binding to IgA, IgG, and IgE antibodies were analyzed, a more strong discrimination of CF patients with ABPA was possible from the other groups studied. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=129596 Fri, 21 Jul 2006 06:00:00 +0100 129596 http://www.medworm.com/index.php?rid=57790&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F9 Conclusions: Comprehensive characterization of genetic variation in extended cytokine candidate gene regions is now needed. Large study networks must follow to investigate the association of risk patterns defined by genetic predisposing and environmental risk factors with specific atopic phenotypes. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=57790 Wed, 07 Jun 2006 06:00:00 +0100 57790 http://www.medworm.com/index.php?rid=44124&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F8 In spite of recent advances with experiments on animal models, strongyloidiasis, an infection caused by the nematode parasite Strongyloides stercoralis, has still been an elusive disease. Though endemic in some developing countries, strongyloidiasis still poses a threat to the developed world. Due to the peculiar but characteristic features of autoinfection, hyperinfection syndrome involving only pulmonary and gastrointestinal systems, and disseminated infection with involvement of other organs, strongyloidiasis needs special attention by the physician, especially one serving patients in areas endemic for strongyloidiasis. Strongyloidiasis can occur without any symptoms, or as a potentially fatal hyperinfection or disseminated infection. Th2 cell-mediated immunity, humoral immunity and muc... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=44124 Tue, 30 May 2006 06:00:00 +0100 44124 http://www.medworm.com/index.php?rid=93&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F7 Conclusion: The present results indicate that a possible link exists between CRS and lower airway hypersensitivity. Sinusitis derived SEB may play a role in sustaining Th2 responses in the low airway hypersensitivity related to sinusitis. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=93 Sun, 07 May 2006 06:00:00 +0100 93 http://www.medworm.com/index.php?rid=94&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F6 Conclusion: We conclude that even though allergen and antigen induced increased chemokine receptor expression, no differences in profiles were identified in memory Th cells from patient groups with different atopic status. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=94 Wed, 19 Apr 2006 06:00:00 +0100 94 http://www.medworm.com/index.php?rid=95&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F5 The objective of this study was to assess whether HDM components of Dermatophagoides pteronissinus with protease activity (Der p 1) and unknown enzymatic activity (Der p 2, Der p 5) induce biological responses in a human airway-derived epithelial cell line (A549), and if so, to elucidate the underlying mechanism(s) of action. A549 cells were incubated with HDM extract, Der p 1, recombinant Der p 2 and recombinant Der p 5. Cell desquamation was assessed by microscopy. The proinflammatory cytokines, IL-6 and IL-8, were measured by ELISA. Intracellular Ca2+ levels were assessed in A549 cells and in mouse fibroblasts expressing the human protease activated receptor (PAR)1, PAR2 or PAR4. HDM extract, Der p 1 and Der p 5 dose-dependently increased the production of IL-6 and IL-8. Added simultane... Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=95 Tue, 28 Mar 2006 07:00:00 +0100 95 http://www.medworm.com/index.php?rid=96&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F4 Conclusion: Vaccination with DNA encoding the major house dust mite allergens provides a promising approach for treating allergic responses to whole house dust mite allergens. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=96 Mon, 20 Feb 2006 07:00:00 +0100 96 http://www.medworm.com/index.php?rid=98&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F2 Conclusion: We conclude from our data that IL8 might play a role in the genetic predisposition to asthma and that these effects are different or even opposite to the effects on severe RSV diseases. Furthermore, IL8RA is unlikely to play a major role in the genetics of either disease. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=98 Fri, 17 Feb 2006 07:00:00 +0100 98 http://www.medworm.com/index.php?rid=97&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F3 Conclusion: The presence of IL-4Rα SNPs, principally ile75val, appears to be a genetic risk for the development of ABPA. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=97 Fri, 17 Feb 2006 07:00:00 +0100 97 http://www.medworm.com/index.php?rid=99&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F4%2F1%2F1 Conclusion: Aluminum sulfate was found to reduce the in vivo allergic reaction cascade induced by skin testing with common allergens. The exact mechanism is not clear but appears to involve the alteration of IgE-binding epitopes on the allergen. Our results indicate that it may be possible to diminish the allergenicity of an environment by application of the active agent aluminum sulfate, thus producing environmental control without complete removal of the allergen. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=99 Tue, 14 Feb 2006 07:00:00 +0100 99 http://www.medworm.com/index.php?rid=100&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F3%2F1%2F16 A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=100 Fri, 23 Dec 2005 07:00:00 +0100 100 http://www.medworm.com/index.php?rid=101&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F3%2F1%2F15 Conclusion: Our results show a trend of association between the genetic combination of the T allele of -33C>TIL4 and the A allele of 576Q>RIL4RA with asthma. This genetic variant was more frequently observed in patients with persistent asthma. As long as this study was performed in a small population, further studies in other populations are needed to confirm these results. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=101 Tue, 29 Nov 2005 07:00:00 +0100 101 http://www.medworm.com/index.php?rid=102&cid=s_33172_3_f&fid=33172&url=http%3A%2F%2Fwww.clinicalmolecularallergy.com%2Fcontent%2F3%2F1%2F14 Conclusion: Severe IgE-mediated reactions can occur following non-occupational guinea pig exposure. Physicians should be aware of this possibility. (Source: Clinical and Molecular Allergy) Clinical and Molecular Allergy journals http://www.medworm.com/rss/comments.php?id=102 Thu, 27 Oct 2005 06:00:00 +0100 102