MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinical and Translational Science' source. Thu, 09 Feb 2012 14:07:51 +0100 http://www.medworm.com/index.php?rid=5592760&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00363.x AbstractAlpha1‐antitrypsin (AT) deficiency is the most common genetic cause of liver disease in children and is also a cause of chronic hepatic fibrosis, cirrhosis, and hepatocellular carcinoma in adults. Recent advances in understanding how mutant AT molecules accumulate within hepatocytes and cause liver cell injury have led to a novel strategy for chemoprophylaxis of this liver disease. This strategy involves a class of drugs, which enhance the intracellular degradation of mutant AT and, because several of these drugs have been used safely in humans for other indications, the strategy can be moved immediately into clinical trials. In this review, we will also report on advances that provide a basis for several other strategies that could be used in the future for treatment of the live... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592760 Tue, 10 Jan 2012 05:00:00 +0100 5592760 http://www.medworm.com/index.php?rid=5592759&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00364.x AbstractThe rates of obesity, diabetes, and heart disease in Native Americans and Alaska Natives far exceed that of the general US population. There are many postulating reasons for these excessive rates including the transition from a traditional to a contemporary diet. Although information on the dietary intakes of Native American and Alaska Native communities are limited, there seems to be a consensus that the Native American and Alaska Native diet is high in total fat, saturated fat, cholesterol, and sodium. Further information on the diet needs to be attained so that dietary interventions can effectively be implemented in these communities. An approach that is community based is proposed as the best solution to understanding the Native diet and developing culturally tailored intervent... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592759 Tue, 10 Jan 2012 05:00:00 +0100 5592759 http://www.medworm.com/index.php?rid=5592758&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00366.x We examined focus groups, the literature, competencies derived for clinical and translational scholars, mentor training curricula, mentor evaluation forms and finally conducted an expert panel process in order to compose this list. These efforts resulted in a set of competencies that include generic competencies expected of all mentors, competencies specific to scientists, and competencies that are clinical and translational research specific. They are divided into six thematic areas: (1) Communication and managing the relationship, (2) Psychosocial support, (3) Career and professional development, (4) Professional enculturation and scientific integrity, (5) Research development, and (6) Clinical and translational investigator development. For each thematic area, we have listed associated ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592758 Tue, 10 Jan 2012 05:00:00 +0100 5592758 http://www.medworm.com/index.php?rid=5592757&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00367.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592757 Tue, 10 Jan 2012 05:00:00 +0100 5592757 http://www.medworm.com/index.php?rid=5592756&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00370.x AbstractHibernation is an extreme physiological challenge for the brown bear (Ursus arctos) in which metabolism is based mainly on lipids. The study objective was to compare plasma lipids in hibernating and active free‐ranging brown bears and relate them to arterial histopathology. Blood was drawn from seven immobilized free‐ranging brown bears (three females, 2–3 years old) during hibernation in February and from the same bears while active in June and analyzed by enzymatic and automated hematology methods within 48 hours of sampling. Left anterior descending coronary arteries and aortic arches from 12 bears (six females, 1.5–12 years old) killed in hunting were examined by histopathology. Total plasma cholesterol decreased from hibernation to the active period (11.08 ± 1.04 mmol... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592756 Tue, 10 Jan 2012 05:00:00 +0100 5592756 http://www.medworm.com/index.php?rid=5592755&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00371.x AbstractThis commentary is germane for clinical and translational researchers. Basic scientists may face different obstacles to developing their research careers. Over the past several years, the federal government has seen reductions in funding for extramural research. It seems that under the adverse economic forecasts, things are going to get worse. It might seem logical for the federal government to stretch whatever limited resources exist, by asking the institutions to cost‐share greater fractions of the actual research costs, and as an incentive, avoid the imposition of unfunded mandates. But alas, although well intended, there have been expensive requirements imposed by the government, making it difficult for investigators and institutions to adequately fund and conduct their resea... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592755 Tue, 10 Jan 2012 05:00:00 +0100 5592755 http://www.medworm.com/index.php?rid=5592754&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00372.x In conclusion, by ­using a proteomic approach, this pilot‐study provides evidence of GPI‐PLD as a novel potential plasma biomarker for AAA. Clin Trans Sci 2011; Volume #: 1–4 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592754 Tue, 10 Jan 2012 05:00:00 +0100 5592754 http://www.medworm.com/index.php?rid=5500972&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00368.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5500972 Tue, 13 Dec 2011 05:00:00 +0100 5500972 http://www.medworm.com/index.php?rid=5482867&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00302.x AbstractAcute kidney injury (AKI) is a common, heterogeneous, and detrimental clinical condition that has significant attributable morbidity and mortality. Despite major advances in understanding the epidemiology, pathogenesis, and outcomes of AKI, preventive measures remain inadequate and therapeutic approaches (except for renal replacement therapy) have largely proven futile so far. Critical to the process of designing rational therapies is translational research, which involves the transition between the basic research discoveries and everyday clinical applications to prevent, diagnose, and treat human diseases. Progress in innovative approaches has been hampered due in part to the reliance on functional markers (serum creatinine and blood urea nitrogen) that are neither sensitive nor s... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5482867 Wed, 07 Dec 2011 05:00:00 +0100 5482867 http://www.medworm.com/index.php?rid=5482866&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00306.x AbstractAutosomal recessive polycystic kidney disease (ARPKD) is a developmental disorder that mainly affects the kidneys and the biliary tract. Affected patients often have massively enlarged cystic kidneys as well as congenital hepatic fibrosis (CHF) characterized by dilated bile ducts and associated peribiliary fibrosis. This review will examine what is known about ARPKD‐associated liver disease and will highlight areas of ongoing research into its pathogenesis and potential treatment. Clin Trans Sci 2011; Volume #: 1–6 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5482866 Wed, 07 Dec 2011 05:00:00 +0100 5482866 http://www.medworm.com/index.php?rid=5482865&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00344.x In conclusion, CETP inhibition by torcetrapib improves RCT in CETP‐apoB100 mice. These results emphasize the potential of CETP inhibition to prevent cardiovascular diseases. Clin Trans Sci 2011; Volume #: 1–7 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5482865 Wed, 07 Dec 2011 05:00:00 +0100 5482865 http://www.medworm.com/index.php?rid=5592753&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00373.x AbstractSingle nucleotide polymorphisms (SNPs) in the promoter and untranslated region of cyclooxygenase (COX)‐2, an inducible enzyme responsible for the synthesis of prostaglandins, have been reported to modulate the risk for many human cancers. We performed comprehensive linkage disequilibrium (LD) and haplotype analyses of 13 single nucleotide polymorphisms of the COX‐2 gene and examined its susceptibility to adenoma development in 72 African American cases and 142 controls. Results revealed significant variation in LD patterns with consequence for adenoma development. Two distinct haplotype blocks were identified; one block covered the coding regions of exon 1, introns and a section of the 3′‐unstranslated region (3′‐UTR), whereas the second block resided solely in the 3′... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5592753 Thu, 01 Dec 2011 05:00:00 +0100 5592753 http://www.medworm.com/index.php?rid=5549600&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00358.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5549600 Thu, 01 Dec 2011 05:00:00 +0100 5549600 http://www.medworm.com/index.php?rid=5437146&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00359.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5437146 Tue, 22 Nov 2011 05:00:00 +0100 5437146 http://www.medworm.com/index.php?rid=5437145&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00360.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5437145 Tue, 22 Nov 2011 05:00:00 +0100 5437145 http://www.medworm.com/index.php?rid=5396597&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00309.x AbstractMicroarray technologies enable the simultaneous interrogation of expressions from thousands of genes from a biospecimen sample taken from a patient. This large set of expressions generates a genetic profile of the patient that may be used to identify potential prognostic or predictive genes or genetic models for clinical outcomes. The aim of this article is to provide a broad overview of some of the major statistical considerations for the design and analysis of microarrays experiments conducted as correlative science studies to clinical trials. An emphasis will be placed on how the lack of understanding and improper use of statistical concepts and methods will lead to noise discovery and misinterpretation of experimental results. Clin Trans Sci 2011; Volume #: 1–12 (Source: Clin... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5396597 Mon, 07 Nov 2011 05:00:00 +0100 5396597 http://www.medworm.com/index.php?rid=5396596&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00320.x AbstractTranslational Science Search (TSS; http://tscience.nlm.nih.gov) is a web application for finding MEDLINE/PubMed journal articles that are regarded by their authors as novel, promising, or may have potential clinical application. A set of “translational” filters and related terms was created by reviewing journal articles published in clinical and translational science (TS) journals. Through E‐Utilities, a user’s query and TS filters are submitted to PubMed, and then, the retrieved PubMed citations are matched with a database of MeSH terms (for disease conditions) and RxNorm (for interventions) to locate the search term, translational filters found, and associated interventions in the title and abstract. An algorithm ranks the interventions and conditions, and then highlights... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5396596 Mon, 07 Nov 2011 05:00:00 +0100 5396596 http://www.medworm.com/index.php?rid=5396595&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00346.x AbstractHealth disparities may affect any person in any community in the world, resulting from a multitude of factors including socioeconomic status, race, ethnicity, environment, and genetics. The impact of health disparities is felt by affected individuals, their families, communities, and the greater health care system.There is a critical need to increase health disparities research activities. This may be achieved by expanding and strengthening the training, education and career development of motivated clinicians, physicians and basic scientists, engaging them in clinical and translational research. Translational research relies on collaboration across disciplines, facilitating the dissemination and transfer of knowledge to populations for the overall improvement of health while decre... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5396595 Mon, 07 Nov 2011 05:00:00 +0100 5396595 http://www.medworm.com/index.php?rid=5396594&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00323.x AbstractResearch training has enabled academic clinicians to contribute significantly to the body of medical research literature. Biostatistics represents a critical methodological skill for such researchers, as statistical methods are increasingly a necessary part of medical research. However, there is no validated knowledge and skills assessment for graduate level biostatistics for academic medical researchers. In this paper, I review graduate level statistical competencies and existing instruments intended to assess physicians’ ability to read the medical literature and for undergraduate statistics for their alignment with core competencies necessary for successful use of statistics. This analysis shows a need for a new instrument to assess biostatistical competencies for medical rese... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5396594 Mon, 07 Nov 2011 05:00:00 +0100 5396594 http://www.medworm.com/index.php?rid=5396593&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00349.x Conclusions: Participants join studies for varied, complex reasons, notably altruism and personal relevance. They value staff relationships, health gains, new knowledge, and compensation, and expect professionalism and good organization. On the basis of these insights, we propose specific actions to enhance participant recruitment, retention, and satisfaction. Clin Trans Sci 2011; Volume #: 1–11 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5396593 Mon, 07 Nov 2011 05:00:00 +0100 5396593 http://www.medworm.com/index.php?rid=5396592&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00357.x Abstract(‐)‐Epicatechin (Epi), a flavanol in cacao stimulates mitochondrial volume and cristae density and protein markers of skeletal muscle (SkM) mitochondrial biogenesis in mice. Type 2 diabetes mellitus (DM2) and heart failure (HF) are diseases associated with defects in SkM mitochondrial structure/function. A study was implemented to assess perturbations and to determine the effects of Epi‐rich cocoa in SkM mitochondrial structure and mediators of biogenesis. Five patients with DM2 and stage II/III HF consumed dark chocolate and a beverage containing approximately 100 mg of Epi per day for 3 months. We assessed changes in protein and/or activity levels of oxidative phosphorylation proteins, porin, mitofilin, nNOS, nitric oxide, cGMP, SIRT1, PGC1α, Tfam, and mitochondria volume ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5396592 Mon, 07 Nov 2011 05:00:00 +0100 5396592 http://www.medworm.com/index.php?rid=5500971&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00369.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5500971 Sat, 01 Oct 2011 04:00:00 +0100 5500971 http://www.medworm.com/index.php?rid=5492446&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00312.x This article reviews published studies in which molecular analysis was performed in the evaluation of pancreatic cysts. The molecular studies are compared with the conventional tests. Most studies have had moderate sample sizes (16–124) and have characterized a high proportion of patients with malignant cysts. Evaluation of molecular analysis as a diagnostic tool merits larger prospective trials with long‐term follow‐up of patients who are not sent to surgery. Larger cysts may meet size criteria for resection, and it is the smaller cysts for which molecular analysis may be of benefit if additional molecular testing results in a change in management. Clin Trans Sci 2011; Volume #: 1–6 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5492446 Sat, 01 Oct 2011 04:00:00 +0100 5492446 http://www.medworm.com/index.php?rid=5482864&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00351.x AbstractDisseminated intravascular coagulation (DIC) profoundly increases the morbidity and mortality of patients who have sepsis. Both laboratory and clinical research advanced the understanding of the biology and pathophysiology of DIC. This, in turn, gave rise to improved therapies and patient outcomes. Beginning with a stimulus causing disruption of vascular integrity, cytokines and chemokines cause activation of systemic coagulation and inflammation. Seemingly paradoxically, the interplay between coagulation and inflammation also inhibits endogenous anticoagulants, fibrinolytics, and antiinflammatory pathways. The earliest documented and best‐studied microbial cause of DIC is the lipopolysaccharide endotoxin of Gram‐negative bacteria. Extensive microvascular thrombi emerge in the ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5482864 Sat, 01 Oct 2011 04:00:00 +0100 5482864 http://www.medworm.com/index.php?rid=5465033&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00365.x AbstractClinical research nursing is a specialty nursing practice focused on the care of research subjects and implementation of clinical research. A five‐dimensional model (Clinical Practice [CP], Study Management, Care Coordination and Continuity, Contributing to the Science [CS], Human Subjects Protection) has been validated nationally to represent the domain of clinical research nursing practice. The purpose of this study was to describe the frequency and importance of activities within each dimension as performed by nurses in clinical research and to describe differences between roles. One thousand and four nurses from the NIH Intramural Campus in Bethesda, Maryland, were invited to participate in an anonymous web‐based survey. Participants (N = 412) were predominantly female (9... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5465033 Sat, 01 Oct 2011 04:00:00 +0100 5465033 http://www.medworm.com/index.php?rid=5453925&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00361.x This article presents a new and innovative six‐component approach to mentor evaluation that includes the assessment of mentee training and empowerment, peer learning and mentor training, scholar advocacy, mentee–mentor expectations, mentor self‐reflection, and mentee evaluation of their mentor. Clin Trans Sci 2011; Volume #: 1–7. (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5453925 Sat, 01 Oct 2011 04:00:00 +0100 5453925 http://www.medworm.com/index.php?rid=5437144&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00362.x Conclusions: This program for developing nascent partnerships between academicians and community members may guide others in increasing capacity for CBPR. Clin Trans Sci 2011; Volume #: 1–6 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5437144 Sat, 01 Oct 2011 04:00:00 +0100 5437144 http://www.medworm.com/index.php?rid=5427834&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00356.x We examined three questions: (1) What is the value in assuring that the expectations of scholars and mentors are mutually identified and aligned? (2) What types of programmatic interventions facilitate this process? (3) What types of expectations are important to identify and align? We addressed these questions through a systematic literature review, focus group interviews of mentors and scholars, a survey of Clinical and Translational Science Award (CTSA) KL2 program directors, and review of formal programmatic mechanisms used by KL2 programs. We found broad support for the importance of identifying and aligning the expectations of scholars and mentors and evidence that mentoring contracts, agreements, and training programs facilitate this process. These tools focus on aligning expectatio... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5427834 Sat, 01 Oct 2011 04:00:00 +0100 5427834 http://www.medworm.com/index.php?rid=5396591&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00348.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5396591 Sat, 01 Oct 2011 04:00:00 +0100 5396591 http://www.medworm.com/index.php?rid=5355144&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00345.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355144 Sat, 01 Oct 2011 04:00:00 +0100 5355144 http://www.medworm.com/index.php?rid=5355143&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00299.x Abstract Enteroendocrine cells (EECs) play a key role in nutrient digestion and absorption, and are essential for normal life. Recently, EEC function has received considerable attention because several gastrointestinal hormones modulate insulin secretion and food intake; and, gut hormone‐based therapies have been developed to treat diabetes mellitus. Despite these advances, the regulation of EECs remains poorly understood. The development of transgenic mouse models that express green fluorescent proteins (GFP) under specific hormone promoters (e.g., peptide YY‐GFP) is shedding light onto previously overlooked features of EECs. These cells have prominent cytoplasmic processes that extend underneath enterocytes, and in some EECs, such as the L cell of the distal ileum, the basal proces... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355143 Sat, 01 Oct 2011 04:00:00 +0100 5355143 http://www.medworm.com/index.php?rid=5355142&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00283.x Abstract Although stem cell therapy is not a new field, the field was limited to transplantation of hematopoietic stem cells. Such transplantation has provided invaluable information for the emerging field with new stem cells. Mesenchymal stem cells (MSCs) are an attractive source for therapy; reduced ethical concern, ease in expansion, as off‐the‐shelf stem cells. MSCs exert immune suppressive properties, providing them with the potential for immune suppressive therapy such as autoimmunity, asthma, allergic rhinitis and graft versus host disease. In addition, MSCs, as well as other stem cells, can be applied for bone and cartilage repair, cardiovascular disease, and neural repair/protection. The data thus far with MSCs are mixed. This review discusses the immune‐enhancing properti... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355142 Sat, 01 Oct 2011 04:00:00 +0100 5355142 http://www.medworm.com/index.php?rid=5355141&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00287.x Abstract A little more than 10 years ago, the completed sequencing of the human genome boldly promised to usher in an era of enhanced understanding and accelerated development of treatments for most human diseases. Ten years later, many of these therapeutic goals have not been reached, but genomic technologies have dramatically enhanced our understanding of how genes and gene networks contribute to the pathogenesis of disease. In this review, we describe how genomic technologies have shaped our study of idiopathic pulmonary fibrosis (IPF), a devastating, progressive scarring of the lung parenchyma, a disease without a known cause, or treatment. We frame the important genomic discoveries in IPF of the previous decade in the clinical context of establishing a diagnosis of IPF and predictin... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355141 Sat, 01 Oct 2011 04:00:00 +0100 5355141 http://www.medworm.com/index.php?rid=5355140&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00324.x This article presents a novel visual analytics (VA)‐based clinical decision support (CDS) tool prototype that was designed as a collaborative work between Renaissance Computing Institute and Duke University. Using Major Depressive Disorder data from MindLinc electronic health record system at Duke, the CDS tool shows an approach to leverage data from comparative population (patients with similar medical profile) to enhance a clinicians’ decision making process at the point of care. The initial work is being extended in collaboration with the University of North Carolina CTSA to address the key challenges of CDS, as well as to show the use of VA to derive insight from large volumes of Electronic Health Record patient data. Clin Trans Sci 2011; Volume 4: 369–371 (Source: Clinical and T... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355140 Sat, 01 Oct 2011 04:00:00 +0100 5355140 http://www.medworm.com/index.php?rid=5355139&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00285.x Abstract Recruiting volunteers into clinical research remains a significant challenge for many clinical research study teams, thus the Michigan Institute for Clinical and Health Research (MICHR) at the University of Michigan developed UMClinicalStudies (http://www.UMClinicalStudies.org)—a Web application that links the community to a single gateway for clinical research. UMClinicalStudies (formerly named “Engage”) is an integral piece of MICHR’s efforts to increase clinical research participation in order to advance medical discoveries. Despite the initial success of the application, barriers to research participation remain, including the applications accessibility for potential research volunteers and study team members. In response, new initiatives were instigated to identify ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355139 Sat, 01 Oct 2011 04:00:00 +0100 5355139 http://www.medworm.com/index.php?rid=5355138&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00288.x This article outlines issues to be taken into account as curricula are planned, implemented, and evaluated. It also discusses how philosophy, competencies, and assessments, including milestones, must be intertwined purposefully, with careful attention paid to the integration of knowledge, skills, and attitudes. Clin Trans Sci 2011; Volume 4: 359–362 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355138 Sat, 01 Oct 2011 04:00:00 +0100 5355138 http://www.medworm.com/index.php?rid=5355137&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00317.x Abstract The goal of this paper is to review the evaluation of mentors with a focus on training new investigators in clinical translational science. These scholars include physicians and Ph.D. scientists who are generally assistant professors in clinical departments. This white paper is one of a series of articles focused on the programmatic elements of effective mentoring practices and the “current state of the art.” Evaluating mentor performance and providing formative feedback can lead to stronger mentoring and ultimately lead to increased success of new clinical and translational investigators. While there is general agreement that mentor evaluation can be helpful, the process is difficult. Trainees are reluctant to share negative experiences and to rate their mentors. Mentors ar... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355137 Sat, 01 Oct 2011 04:00:00 +0100 5355137 http://www.medworm.com/index.php?rid=5355136&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00305.x Abstract The contribution of copy number variation (CNV) to dilated cardiomyopathy (DCM) is unknown. However, estimates have suggested that CNVs could constitute 15% of mutations underlying Mendelian disease. This is of particular relevance to DCM, where only approximately 35% of genetic cause has been identified. We have previously reported 19 point mutations in LMNA, the gene encoding Lamin A/C, in a cohort of 324 unrelated DCM probands (5.9%), making it the most common genetic cause of DCM. Recently a large deletion was reported in LMNA in 1 of 25 DCM probands. To further assess the contribution of CNVs in LMNA cardiomyopathy, we used Multiplex Ligation Probe Amplification (MLPA) to screen for large deletions and duplications in 58 DCM probands negative for point mutations in LMNA. De... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355136 Sat, 01 Oct 2011 04:00:00 +0100 5355136 http://www.medworm.com/index.php?rid=5355135&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00318.x Conclusions: These results demonstrate that the expression of neuropeptides and their receptors in the diabetic heart is significantly impaired, and may be the link between neuropathy and cardiac complications. Further studies are warranted to delineate pathophysiologic mechanisms associated with dysregulation of the cardiac neuropeptide system and the relationship to cardiac complications in diabetes. Clin Trans Sci 2011; Volume 4: 346–350 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355135 Sat, 01 Oct 2011 04:00:00 +0100 5355135 http://www.medworm.com/index.php?rid=5355134&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00353.x Abstract Despite a push to create electronic health records and a plethora of healthcare data from disparate sources, there are no data from a single electronic source that provide a full picture of a patient’s hospital course. This paper describes a process to utilize electronically available inpatient hospital data for research. We linked several different sources of extracted data, including clinical, procedural, administrative, and accounting data, using patients’ medical record numbers to compile a cohesive, comprehensive account of patient encounters. Challenges encountered included (1) interacting with distinct administrative units to locate data elements; (2) finding a secure, central location to house the data; (3) appropriately defining health measures of interest; (4) obta... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355134 Sat, 01 Oct 2011 04:00:00 +0100 5355134 http://www.medworm.com/index.php?rid=5355133&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00347.x Abstract Advances in clinical and translation science are facilitated by building on prior knowledge gained through experimentation and observation. In the context of drug development, preclinical studies are followed by a progression of phase I through phase IV clinical trials. At each step, the study design and statistical strategies are framed around research questions that are prerequisites for the next phase. In other types of biomedical research, pilot studies are used for gathering preliminary support for the next research step. However, the phrase “pilot study” is liberally applied to projects with little or no funding, characteristic of studies with poorly developed research proposals, and usually conducted with no detailed thought of the subsequent study. In this article, w... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355133 Sat, 01 Oct 2011 04:00:00 +0100 5355133 http://www.medworm.com/index.php?rid=5355132&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00308.x Abstract One of the objectives of the Consortium of Institutions with Clinical and Translational Science Awards (CTSAs) is to enhance technology transfer among the CTSAs and with public and private sector partners. Clinical and Translational Sciences Award Intellectual Property (CTSA‐IP; http://www.CTSAIP.org) is a web‐based, open access IP search tool that aggregates and promotes technologies from member institutions of the National Institutes of Health’s (NIH) CTSAs consortium. Its ultimate aim is to stimulate collaborative research activity by encouraging the formation of public‐private partnerships with CTSA institutions and the NIH. First launched in 2009, CTSA‐IP has grown rapidly and met its first objectives of developing wide member institution participation and site us... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355132 Sat, 01 Oct 2011 04:00:00 +0100 5355132 http://www.medworm.com/index.php?rid=5355131&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00314.x The objective of this study was (1) to identify the frequency and effect size of common obesity genetic variants in Latina women; (2) to determine the clinical utility of a GRS for obesity with Latina women participating in a community‐based clinical trial. DNA from 85 Latina women was genotyped for eight genetic variants previously associated with BMI in Caucasians, but not yet assessed in Latina populations. The main outcome measure was the correlation of GRS (sum of eight risk alleles) with BMI, waist circumference, and percent body fat. A majority (83%) of participants had a BMI ≥25. Frequency of loci near FTO, MC4R, and GNPDA2 were lower in Latinas than Caucasians. Association of each locus with BMI was lower in Latinas compared to Caucasians with no significant correlations with ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355131 Sat, 01 Oct 2011 04:00:00 +0100 5355131 http://www.medworm.com/index.php?rid=5355130&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00313.x Conclusions: A cellular autoimmune response to cTnI is demonstrated in a subset of patients with iDCM. However, the presence of a cellular response did not correlate with the presence of AAbs to the same antigen. Clin Trans Sci 2011; Volume 4: 317–322 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355130 Sat, 01 Oct 2011 04:00:00 +0100 5355130 http://www.medworm.com/index.php?rid=5355129&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00343.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355129 Sat, 01 Oct 2011 04:00:00 +0100 5355129 http://www.medworm.com/index.php?rid=5355128&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00352.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355128 Sat, 01 Oct 2011 04:00:00 +0100 5355128 http://www.medworm.com/index.php?rid=5355127&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00350.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355127 Sat, 01 Oct 2011 04:00:00 +0100 5355127 http://www.medworm.com/index.php?rid=5355126&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00354.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355126 Sat, 01 Oct 2011 04:00:00 +0100 5355126 http://www.medworm.com/index.php?rid=5355125&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00355.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5355125 Sat, 01 Oct 2011 04:00:00 +0100 5355125 http://www.medworm.com/index.php?rid=5173842&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00281.x AbstractHuman embryonic stem cells (hESCs) hold great promise for ushering in an era of novel cell therapies to treat a wide range of rare and common diseases, yet they also provide an unprecedented opportunity for basic research to yield clinical benefit. HESCs can be used to better understand human development, to model human diseases, to understand the contribution of specific mutations to the pathogenesis of disease, and to develop human cell‐based screening systems to identify novel therapeutic agents and evaluate potential toxicity of therapeutic agents under development. Such basic research will benefit greatly from efficient methods to perform targeted gene modification, an area of hESC investigation that is currently in its infancy. Moreover, the reality of hESC‐based cellular... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173842 Sun, 31 Jul 2011 23:00:00 +0100 5173842 http://www.medworm.com/index.php?rid=5173841&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00316.x This report describes four diverse programs of community‐engaged research, all of which demonstrated positive health outcomes. Three of the programs were focused on communities of people with diabetes, and one program targeted at‐risk young families raising infants and young children. Brief descriptions of each research study and outcomes are presented as well as a discussion of the processes and lessons that were learned from each model of successful interdisciplinary community‐university health research partnerships. Clin Trans Sci 2011; Volume 4: 285–297 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173841 Sun, 31 Jul 2011 23:00:00 +0100 5173841 http://www.medworm.com/index.php?rid=5173840&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00307.x Conclusions: The IL28B CC genotype does not account for the noted HIV control in our specific NVS cohort. Further studies will be needed to determine if a common genetic factor can primarily account for any joint clearance of HCV and control of HIV. Clin Trans Sci 2011; Volume 4: 282–284 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173840 Sun, 31 Jul 2011 23:00:00 +0100 5173840 http://www.medworm.com/index.php?rid=5173839&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00297.x AbstractThe journey of gene transfer from laboratory to clinic has been slow and fraught with many challenges and barriers. Despite the development of the initial technology in the early 1970s, a standard clinical treatment involving “gene therapy” remains to be seen. Furthermore, much was written about the technology in the early 1990s, but since then, not much has been written about the journey of gene transfer. The translational path of gene transfer thus far, both pitfalls and successes, can serve as a study not only in navigating ethical and safety concerns, but also in the importance of scientist–public interactions. Here, we examine the translational progress of gene transfer and what can be gleaned from its history. Clin Trans Sci 2011; Volume 4: 279–281 (Source: Clinical a... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173839 Sun, 31 Jul 2011 23:00:00 +0100 5173839 http://www.medworm.com/index.php?rid=5173838&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00321.x This study investigates the role of individual‐level predictors of the choice to join a new IDR team at a major medical institution. We collected survey data from a sample of 233 faculty members who were given the opportunity to participate in IDR teams that had recently formed around a wide range of medical topic areas. Our results suggest that even under supportive organizational conditions, some medical experts were more likely to participate than others. Specifically, basic and translational researchers, associate professors, and faculty with distinctive topic area expertise and with more experience collaborating across departmental boundaries participated at a greater rate than their peers. Our findings have implications for research, practice, and policy focused on overcoming the c... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173838 Sun, 31 Jul 2011 23:00:00 +0100 5173838 http://www.medworm.com/index.php?rid=5173837&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00300.x AbstractProstaglandin E2 (PGE2), interleukin (IL)‐23, and IL‐1beta (β) propagate inflammatory bowel disease (IBD) by enhancing the development and function of IL‐17 producing CD4+ T helper (Th17) cells. CD4+ T cells that express the C‐type lectin‐like receptor CD161 have been proposed to be the physiologic pool of circulating Th17 cells implicated in IBD. We sought to understand how PGE2, alone and in combination with IL‐23 and IL‐1β, modulate human peripheral CD161+CD4+ memory T cells. We found that CD161+ cells comprise a significant proportion of human peripheral CD4+ memory T cells. PGE2 and IL‐23 plus IL‐1β synergistically induced early IL‐17A secretion from CD161+CD4+ memory T cells and the selective enrichment of IL‐17A+CD161+CD4+ memory T cells in culture. ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173837 Sun, 31 Jul 2011 23:00:00 +0100 5173837 http://www.medworm.com/index.php?rid=5173836&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00296.x AbstractOver the past two decades, the health research enterprise has matured rapidly, and many recognize an urgent need to translate pertinent research results into practice, to help improve the quality, accessibility, and affordability of US healthcare. Streamlining research operations would speed translation, particularly for multisite collaborations. However, the culture of research discourages reusing or adapting existing resources or study materials. Too often, researchers start studies and multisite collaborations from scratch—reinventing the wheel. Our team developed a compendium of resources to address inefficiencies and researchers’ unmet needs and compiled them in a research toolkit website (http://www.ResearchToolkit.org). Through our work, we identified philosophical and o... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173836 Sun, 31 Jul 2011 23:00:00 +0100 5173836 http://www.medworm.com/index.php?rid=5173835&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00310.x Conclusion: The PRIMER Research Toolkit (http://www.researchtoolkit.org) provides an array of peer‐reviewed resources to facilitate translational research for the conduct of multisite studies within PBRNs and community‐based organizations. Clin Trans Sci 2011; Volume 4: 259–265 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173835 Sun, 31 Jul 2011 23:00:00 +0100 5173835 http://www.medworm.com/index.php?rid=5173834&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00301.x AbstractIron homeostasis influences the development of pulmonary arterial hypertension (PAH) associated with hypoxia or hematologic disorders. To investigate whether severity of idiopathic PAH (IPAH) is impacted by alterations in iron metabolism, we assessed iron metabolic markers, including levels of zinc‐protoporphyrin (Zn‐pp), transferrin receptor, and red blood cell numbers and morphology in IPAH, associated PAH and sleep apnea‐induced pulmonary hypertension patients in comparison to healthy controls and asthmatics. Despite similarly normal measures of iron metabolism, Zn‐pp levels in IPAH and sleep apnea patients were elevated approximately twofold, indicating deficient iron incorporation to form heme and levels were closely related to measures of disease severity. Consistent ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173834 Sun, 31 Jul 2011 23:00:00 +0100 5173834 http://www.medworm.com/index.php?rid=5173833&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00298.x In this report, we demonstrate that a high‐fructose diet in rhesus monkeys produces insulin resistance and many features of the metabolic syndrome, including central obesity, dyslipidemia, and inflammation within a short period of time; moreover, a subset of monkeys developed type 2 diabetes. Given the rapidity with which the metabolic changes occur, and the ability to control for many factors that cannot be controlled for in humans, fructose feeding in rhesus monkeys represents a practical and efficient model system in which to investigate the pathogenesis, prevention, and treatment of diet‐induced insulin resistance and its related comorbidities. Clin Trans Sci 2011; Volume 4: 243–252 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173833 Sun, 31 Jul 2011 23:00:00 +0100 5173833 http://www.medworm.com/index.php?rid=5173832&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00294.x We report here that unlike findings in the brain, cPLA2α(−/−) mice have exaggerated injury following I/R in vivo. In contrast, there is no difference in injury induced by simulated ischemia in cardiomyocytes isolated from cPLA2α(−/−) versus cPLA2α(+/+) mice. This suggests that cPLA2α does not have an important cardiomyocyte autonomous effect on ischemic injury. Prostaglandin E2 (PGE2) levels are significantly reduced in the hearts of the cPLA2α(−/−) mice, and the enhanced injury is ameliorated by treatment with the PGE analog, misoprostol. We demonstrate that cPLA2α is cardioprotective in vivo, and this is likely via cPLA2α‐mediated production of cardioprotective eicosanoids. These studies are the first to identify a protective role for cPLA2 in I/R injury in any organ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173832 Sun, 31 Jul 2011 23:00:00 +0100 5173832 http://www.medworm.com/index.php?rid=5173831&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00319.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173831 Sun, 31 Jul 2011 23:00:00 +0100 5173831 http://www.medworm.com/index.php?rid=5173830&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00311.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173830 Sun, 31 Jul 2011 23:00:00 +0100 5173830 http://www.medworm.com/index.php?rid=5173829&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00315.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173829 Sun, 31 Jul 2011 23:00:00 +0100 5173829 http://www.medworm.com/index.php?rid=5173828&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00322.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=5173828 Sun, 31 Jul 2011 23:00:00 +0100 5173828 http://www.medworm.com/index.php?rid=4974542&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00295.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974542 Tue, 31 May 2011 23:00:00 +0100 4974542 http://www.medworm.com/index.php?rid=4974541&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00262.x AbstractParoxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease that presents with protean manifestations. Clinical and laboratory investigation over the past 25 years has uncovered most of the basic science underpinnings of PNH and has led to the development of a highly effective targeted therapy. PNH originates from a multipotent hematopoietic stem cell (HSC) that acquires a somatic mutation in a gene called phosphatidylinositol glycan anchor biosynthesis, class A (PIG‐A). The PIG‐A gene is required for the first step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. Failure to synthesize GPI anchors leads to an absence of all proteins that utilize GPI to attach to the plasma membrane. Two GPI‐anchor proteins, CD55 and CD59, are complement regulatory protei... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974541 Tue, 31 May 2011 23:00:00 +0100 4974541 http://www.medworm.com/index.php?rid=4974540&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00272.x AbstractResearch over the last decade has uncovered roles for bile acids (BAs) that extend beyond their traditional functions in regulating lipid digestion and cholesterol metabolism. BAs are now recognized as signaling molecules that interact with both plasma membrane and nuclear receptors. Emerging evidence indicates that by interacting with these receptors, BAs regulate their own synthesis, glucose and energy homeostasis, and other important physiological events. Herein, we provide a comprehensive review of the actions of BAs on cardiovascular function. In the heart and the systemic circulation, BAs interact with plasma membrane G‐protein‐coupled receptors, for example, TGR5 and muscarinic receptors, and nuclear receptors, for example, the farnesoid (FXR) and pregnane (PXR) xenobiot... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974540 Tue, 31 May 2011 23:00:00 +0100 4974540 http://www.medworm.com/index.php?rid=4974539&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00280.x AbstractTo address provider struggles to provide evidence‐based, rational drug therapy to pregnant women, this third Conference was convened to highlight the current progress and research in the field. Speakers from academic centers, industry, and governmental institutions spoke about: the Food and Drug Administration’s role in pregnancy pharmacology and the new labeling initiative; drug registries in pregnancy; the pharmacist’s role in medication use in pregnancy; therapeutic areas such as preterm labor, gestational diabetes, nausea and vomiting in pregnancy, and hypertension; breast‐feeding and medications; ethical challenges for consent in pregnancy drug studies; the potential for cord blood banks; and concerns about the fetus when studying drugs in pregnancy. The Conference hig... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974539 Tue, 31 May 2011 23:00:00 +0100 4974539 http://www.medworm.com/index.php?rid=4974538&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00286.x AbstractThe goal of this paper is to present strategies utilized to support K scholar research mentors. K scholars are generally assistant professors who are close to developing independent research programs. Of all the various types of mentees, K scholars offer the greatest challenges, as well as the greatest rewards, for research mentors. To see one’s mentee achieve independent PI status and become an established investigator is one of the great joys of being a research mentor. Research mentors for K scholars, however, may not directly benefit from their mentoring relationship, neither in terms of obtaining data to support their research program or laboratory, nor in assistance with grants or scientific papers. There is a pressing need for the research community to address the workload... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974538 Tue, 31 May 2011 23:00:00 +0100 4974538 http://www.medworm.com/index.php?rid=4974537&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00282.x AbstractClinical research needs to be more useful to patients, clinicians, and other decision makers. To meet this need, more research should focus on patient‐centered outcomes, compare viable alternatives, and be responsive to individual patients’ preferences, needs, pathobiology, settings, and values. These features, which make comparative effectiveness research (CER) fundamentally patient‐centered, challenge researchers to adopt or develop methods that improve the timeliness, relevance, and practical application of clinical studies.In this paper, we describe 10 priority areas that address 3 critical needs for research on patient‐centered outcomes (PCOR): (1) developing and testing trustworthy methods to identify and prioritize important questions for research; (2) improving the ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974537 Tue, 31 May 2011 23:00:00 +0100 4974537 http://www.medworm.com/index.php?rid=4974536&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00284.x Conclusion: Our data suggest TCF7L2 is associated with altered gastric functions that may predispose to obesity. Clin Trans Sci 2011; Volume 4: 183–187 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974536 Tue, 31 May 2011 23:00:00 +0100 4974536 http://www.medworm.com/index.php?rid=4974535&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00279.x AbstractPlatelets contain mRNAs and are capable of translating mRNA into protein, and it has been previously demonstrated that platelets increase their levels of integrin β3 overtime while in blood bank storage conditions. We are unaware of prior attempts to introduce nucleic acids into platelets. Considering the potential clinical and research utility of manipulating platelet gene expression, we tested whether small interfering RNAs (siRNAs) could be transfected into normal human platelets. Multiple conditions were tested, including lipofectamine versus electroporation, different amounts of siRNA, the effect of different buffers and the presence of plasma during transfection, and the time for optimal siRNA incorporation after transfection. Using flow cytometry to assess transfection effi... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974535 Tue, 31 May 2011 23:00:00 +0100 4974535 http://www.medworm.com/index.php?rid=4974534&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00290.x Conclusion: Since we have previously shown that the ratio of the 17.5‐/22‐kDa GH1 transcripts correlates with severity of the IGHD II phenotype, our findings here suggest that selected previously unconsidered agents could possibly reduce the severity of IGHD II, while other agents could possibly exacerbate the disease phenotype. Clin Trans Sci 2011; Volume 4: 175–179 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974534 Tue, 31 May 2011 23:00:00 +0100 4974534 http://www.medworm.com/index.php?rid=4974533&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00278.x Conclusion: Our findings revealed that EPO, hCG, or their combination ameliorate cardiac remodeling post‐MI. Whereas EPO stimulates neovascularization only and hCG + EPO stimulates c‐kit+ cell proliferation. These data suggest that combining mobilizing and proliferative agents adds to the durability and sustainability of cytokine‐based therapies for remodeling post‐MI. Clin Trans Sci 2011; Volume 4: 168–174 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974533 Tue, 31 May 2011 23:00:00 +0100 4974533 http://www.medworm.com/index.php?rid=4974532&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00289.x Conclusions: Respondents in the Tufts University CTSI catchment area, like many diverse urban communities, described multiple interconnected social determinants of health and well‐being. As such, they were interested in research that focuses on “upstream” areas of intervention as opposed to disease prevention at the individual level. In addition, respondents were interested in research that would catalyze community change. Clin Trans Sci 2011; Volume 4: 163–167 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974532 Tue, 31 May 2011 23:00:00 +0100 4974532 http://www.medworm.com/index.php?rid=4974531&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00291.x Conclusions: This model provides a foundation for the evaluation of interventions designed to improve translational research and the integration of these findings into a field of translational studies. Clin Trans Sci 2011; Volume 4: 153–162 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974531 Tue, 31 May 2011 23:00:00 +0100 4974531 http://www.medworm.com/index.php?rid=4974530&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00304.x AbstractCirculating inflammatory mediators including complement activation products participate in the pathogenesis of cardiovascular diseases. As such, previous reports demonstrating the presence of complement proteins within atherosclerotic plaque and on the luminal surface would be anticipated. In contrast, we have recently made the unexpected observation that complement proteins also deposit along the external elastic lamina of mouse aortas in the absence of luminal deposition or plaque development. This suggests that complement activation may play a critical role in the pathogenesis of vascular stiffness and atherosclerosis through a mechanism initiated within the adventitia rather than on the endothelial surface. This hypothesis was tested in the current study by ultrastructural iden... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974530 Tue, 31 May 2011 23:00:00 +0100 4974530 http://www.medworm.com/index.php?rid=4974529&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00293.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974529 Tue, 31 May 2011 23:00:00 +0100 4974529 http://www.medworm.com/index.php?rid=4974528&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00292.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974528 Tue, 31 May 2011 23:00:00 +0100 4974528 http://www.medworm.com/index.php?rid=4974527&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00303.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4974527 Tue, 31 May 2011 23:00:00 +0100 4974527 http://www.medworm.com/index.php?rid=4675844&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00270.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675844 Thu, 31 Mar 2011 23:00:00 +0100 4675844 http://www.medworm.com/index.php?rid=4675843&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00269.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675843 Thu, 31 Mar 2011 23:00:00 +0100 4675843 http://www.medworm.com/index.php?rid=4675842&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00268_2.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675842 Thu, 31 Mar 2011 23:00:00 +0100 4675842 http://www.medworm.com/index.php?rid=4675841&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00268_1.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675841 Thu, 31 Mar 2011 23:00:00 +0100 4675841 http://www.medworm.com/index.php?rid=4675840&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00273.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675840 Thu, 31 Mar 2011 23:00:00 +0100 4675840 http://www.medworm.com/index.php?rid=4675839&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00271.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675839 Thu, 31 Mar 2011 23:00:00 +0100 4675839 http://www.medworm.com/index.php?rid=4675838&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00274.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675838 Thu, 31 Mar 2011 23:00:00 +0100 4675838 http://www.medworm.com/index.php?rid=4675837&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00275.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675837 Thu, 31 Mar 2011 23:00:00 +0100 4675837 http://www.medworm.com/index.php?rid=4675836&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00276.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675836 Thu, 31 Mar 2011 23:00:00 +0100 4675836 http://www.medworm.com/index.php?rid=4675835&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00277.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4675835 Thu, 31 Mar 2011 23:00:00 +0100 4675835 http://www.medworm.com/index.php?rid=4511593&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00265.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511593 Tue, 01 Feb 2011 00:00:00 +0100 4511593 http://www.medworm.com/index.php?rid=4511592&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00261.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511592 Tue, 01 Feb 2011 00:00:00 +0100 4511592 http://www.medworm.com/index.php?rid=4511591&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00255.x AbstractSevere burns result in T lymphocyte specific immunologic changes. In addition to decreased levels of circulating lymphocytes, changes in cytokine secretion and receptor expression also take place. Our finer understanding of the inflammatory response has led to the development of immune‐targeted therapeutics, requiring specialized gene‐expression monitoring. The emerging field of bio‐micro‐electromechanical systems can be used to isolate highly pure T lymphocytes in a clinically relevant and timely manner for downstream genomic analysis. Blood samples from healthy volunteers and burn‐injured patients were introduced into microfluidic devices developed in our laboratory. Utilizing cell‐affinity chromatography for positive selection of T lymphocytes, the devices served as ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511591 Tue, 01 Feb 2011 00:00:00 +0100 4511591 http://www.medworm.com/index.php?rid=4511590&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00254.x This article focuses on FIPA clinical, pathological, genetic features, and therapeutic management. Clin Trans Sci 2011; Volume 4: 55–62 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511590 Tue, 01 Feb 2011 00:00:00 +0100 4511590 http://www.medworm.com/index.php?rid=4511589&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00257.x AbstractSeasonal viruses present a major cause of morbidity and mortality in temperate climates. Through major pandemics and smaller annual epidemics, viruses such as influenza, respiratory syncytial virus (RSV) and human rhinovirus (HRV) result in lost school and work days for most that are infected and more serious complications for the immunocompromised. The reasons for these viruses showing strict seasonality include but are not limited to the influence of cold weather and humidity on virus particles, human physiology, and human behavior. The relative importance of each is dependent on what geographic scale is being explored as well as the individual region and time period. Theoretical mathematics has also revealed that climatic changes are likely not the only reasons for strong season... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511589 Tue, 01 Feb 2011 00:00:00 +0100 4511589 http://www.medworm.com/index.php?rid=4511588&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00259.x AbstractUpon receipt of the National Institutes of Health Clinical and Translational Science Award, the University of Iowa’s Institute for Clinical and Translational Science committed to develop an infrastructure for research professionals. Three goals were established: (1) identification of research professionals within the University of Iowa, (2) development of an educational series, including orientation and continuing education, and (3) development of a mentoring system. The purpose of this paper is to describe the process of development, initiation, and outcomes of a successful networking, educational, and mentoring system crafted for research professionals at the University of Iowa. Clin Trans Sci 2011; Volume 4: 42–47 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511588 Tue, 01 Feb 2011 00:00:00 +0100 4511588 http://www.medworm.com/index.php?rid=4511587&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00258.x AbstractMany academicians assume that anyone can engage in interdisciplinary research, but it is clear that successful interdisciplinary efforts require mastery of specific competencies that can be learned and improved. This paper describes the development and implementation of a course designed for Master’s, pre‐ and postdoctoral students and research faculty on models of interdisciplinary research skills, based on a set of core competencies. Major challenges included working through institutional structures that made it difficult to offer cross‐school courses, and interpersonal challenges among a diverse group of students from a number of disciplines. Although universities may be poised for interdisciplinary research, strategies for faculty preparation and support are lacking. Inst... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511587 Tue, 01 Feb 2011 00:00:00 +0100 4511587 http://www.medworm.com/index.php?rid=4511586&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00264.x AbstractAfrican American race is an independent risk factor for enhanced oxidative stress and inflammation. We sought to examine whether oxidative‐stress and inflammatory markers that are typically measured in humans also differ by race in cell culture. We compared levels between African American and Caucasian young adults and then separately in human umbilical vein endothelial cells (HUVECs) from both races. We found heightened oxidative stress and inflammation in the African Americans both in vitro and in vivo. African American HUVECs showed higher nitric oxide (NO) levels (10.8 ± 0.4 vs. 8.8 ± 0.7 μmol/L/mg, p = 0.03), Interleukin‐6 (IL‐6) levels (61.7 ± 4.2 vs. 23.9 ± 9.0 pg/mg, p = 0.02), and lower superoxide dismutase activity (15.6 ± 3.3 vs. 25.4 ± 2.8 U/mg, p =... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511586 Tue, 01 Feb 2011 00:00:00 +0100 4511586 http://www.medworm.com/index.php?rid=4511585&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00252.x Conclusions: Adenoviral mediated myocardial delivery of the TIMP‐2 gene improves post‐MI survival and limits adverse remodeling in a murine model of MI. Clin Trans Sci 2011; Volume 4: 24–31 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511585 Tue, 01 Feb 2011 00:00:00 +0100 4511585 http://www.medworm.com/index.php?rid=4511584&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00251.x AbstractA three‐stage approach was undertaken using genome‐wide, case‐control, and case‐only association studies to identify genetic variants associated with heart failure mortality. In an Amish founder population (n = 851), cardiac hypertrophy, a trait integral to the adaptive response to failure, was found to be heritable (h2= 0.28, p = 0.0002) and GWAS revealed 21 candidate hypertrophy SNPs. In a case (n = 1,610)‐control (n = 463) study in unrelated Caucasians, one of the SNPs associated with hypertrophy (rs2207418, p = 8 × 10−6), was associated with heart failure, RR = 1.85(1.25–2.73, p = 0.0019). In heart failure cases rs2207418 was associated with increased mortality, HR = 1.51(1.20–1.97, p = 0.0004). There was consistency between studies, with the GG a... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511584 Tue, 01 Feb 2011 00:00:00 +0100 4511584 http://www.medworm.com/index.php?rid=4511583&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00253.x AbstractIn controlled clinical trials, random assignment of treatment is appropriate only when there is equipoise, that is, no clear preference among treatment options. However, even when equipoise appears absent because prior trials show, on average, one treatment yields superior outcomes, random assignment still may be appropriate for some patients and circumstances. In such cases, enrollment into trials may be assisted by real‐time patient‐specific predictions of treatment outcomes, to determine whether there is equipoise to justify randomization. The percutaneous coronary intervention thrombolytic predictive instrument (PCI–TPI) computes probabilities of 30‐day mortality for patients having ST elevation myocardial infarction (STEMI), if treated with thrombolytic therapy (TT), a... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511583 Tue, 01 Feb 2011 00:00:00 +0100 4511583 http://www.medworm.com/index.php?rid=4511582&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00256.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511582 Tue, 01 Feb 2011 00:00:00 +0100 4511582 http://www.medworm.com/index.php?rid=4511581&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00260.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511581 Tue, 01 Feb 2011 00:00:00 +0100 4511581 http://www.medworm.com/index.php?rid=4511580&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00266.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511580 Tue, 01 Feb 2011 00:00:00 +0100 4511580 http://www.medworm.com/index.php?rid=4511579&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00263.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511579 Tue, 01 Feb 2011 00:00:00 +0100 4511579 http://www.medworm.com/index.php?rid=4511578&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2011.00267.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4511578 Tue, 01 Feb 2011 00:00:00 +0100 4511578 http://www.medworm.com/index.php?rid=4264040&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00250_1.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264040 Wed, 01 Dec 2010 00:00:00 +0100 4264040 http://www.medworm.com/index.php?rid=4264039&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00250.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264039 Wed, 01 Dec 2010 00:00:00 +0100 4264039 http://www.medworm.com/index.php?rid=4264038&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00236.x AbstractBecause obstructive sleep apnea (OSA) is associated with increased levels of inflammatory cytokines, we examined the relationship between OSA and polymorphisms for interleukin‐6 (IL6). Six single nucleotide polymorphisms (SNPs) within IL6 were genotyped in 259 African Americans from the Cleveland Family Study with replication conducted in the Cardiovascular Health Study (n= 124). OSA was dichotomized into apnea hypopnea index (AHI) > 15, or on treatment versus absent: AHI < 5. Logistic regression was conducted, adjusting for age and sex in models with and without body mass index (BMI). SNP IL6–6021 was associated with a decreased risk of OSA after adjusting for BMI (Odds Ratio for T allele 0.24, 95%CI [0.09–0.67], p= 0.006, q= 0.07) under an additive model. This same al... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264038 Wed, 01 Dec 2010 00:00:00 +0100 4264038 http://www.medworm.com/index.php?rid=4264037&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00245.x AbstractSuccessful gene therapy of many genetic diseases requires efficient delivery of the gene to several tissues of the organism. Adeno‐associated virus (AAV) is, to date, the sole vehicle that allows to achieving this result but only at the condition of administering very large amounts of vectors. This, however, raises questions about the feasibility of the large‐scale production and about the safety of the approach. One way to overcome both problems would be to develop strategies that increase the in vivo efficiency. Here, we investigated the effect of fasting on the transduction efficiency of AAV serotypes 2, 6, and 9. The transgene expression was followed for several weeks and vector biodistribution was determined by real‐time polymerase chain reaction (PCR). The results show ... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264037 Wed, 01 Dec 2010 00:00:00 +0100 4264037 http://www.medworm.com/index.php?rid=4264036&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00238.x AbstractLipoprotein (a), [Lp(a)] has many properties in common with low‐density lipoprotein, (LDL) but contains a unique protein apolipoprotein(a), linked to apolipoprotein B‐100 by a single disulfide bond. There is a substantial size heterogeneity of apo(a), and generally smaller apo(a) sizes tend to correspond to higher plasma Lp(a) levels, but this relation is far from linear, underscoring the importance to assess allele‐specific apo(a) levels. The presence of apo(a), a highly charged, carbohydrate‐rich, hydrophilic protein may obscure key features of the LDL moiety and offer opportunities for binding to vessel wall elements. Recently, interest in Lp(a) has increased because studies over the past decade have confirmed and more robustly demonstrated a risk factor role of Lp(a) fo... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264036 Wed, 01 Dec 2010 00:00:00 +0100 4264036 http://www.medworm.com/index.php?rid=4264035&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00233.x AbstractTh17 cells play crucial roles not only in host defense but also in many human autoimmune diseases and corresponding animal models. Although many of the fundamental principles regarding Th17 biology have been rapidly elucidated in mice, there remain numerous controversies regarding the differentiation, plasticity, and pathogenicity of human Th17 cells. In this review, we consider these open questions in comparison to what has already been clarified in mice, and discuss the potential impact of discoveries related to the Th17 pathway on the development of new therapeutic strategies in Th17 driven autoimmune diseases, specifically rheumatoid arthritis. Clin Trans Sci 2010; Volume 3: 319–326 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264035 Wed, 01 Dec 2010 00:00:00 +0100 4264035 http://www.medworm.com/index.php?rid=4264034&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00248.x AbstractTranslational research encompasses the effective movement of new knowledge and discoveries into new approaches for prevention, diagnosis, and treatment of disease. There are many roadblocks to successful bench to bedside research, but few have received as much recent attention as the “valley of death.” The valley of death refers to the lack of funding and support for research that moves basic science discoveries into diagnostics, devices, and treatments in humans, and is ascribed to be the result of companies unwilling to fund research development that may not result in a drug or device that will be utilized in the clinic and conversely, the fact that researchers have no access to the funding needed to carry out preclinical and early clinical development to demonstrate potentia... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264034 Wed, 01 Dec 2010 00:00:00 +0100 4264034 http://www.medworm.com/index.php?rid=4264033&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00240.x AbstractWhile clinical medicine is often well supported by health system information technology infrastructure, clinical research may need to create strategies to use clinical‐medicine informational technology tools. The authors describe a medication‐safety initiative that was carried out in a National Institutes of Health Clinical and Translational Science Award (CTSA)‐sponsored clinical research environment. A web based, medical informatics application was designed and implemented that allowed research groups to build protocol specific, electronic medication templates that were subsequently used to create participant‐specific medication order sets for conductance of clinical research activities in the CTSA‐sponsored clinical research environment. The medical informatics initiat... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264033 Wed, 01 Dec 2010 00:00:00 +0100 4264033 http://www.medworm.com/index.php?rid=4264032&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00239.x AbstractThis paper outlines a number of innovations that we have recently implemented in the Research Methodology Course at the University of Michigan’s School of Public Health. Consistent with the goals of evidence‐based medicine, evidence‐based public health, intrinsic motivation, and phase 4 (T4) translational research, we have placed the emphasis on enhancing the students’ desire to learn—and more specifically on their desire to learn rigorous methods for conducting useful research that delivers practical benefits in a straightforward manner. A dozen innovations, along with some preliminary outcomes, are outlined in detail. Clin Trans Sci 2010; Volume 3: 309–311 (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264032 Wed, 01 Dec 2010 00:00:00 +0100 4264032 http://www.medworm.com/index.php?rid=4264031&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00246.x AbstractThe Clinical and Translational Science Award (CTSA) Consortium Workshop was conceived as a venue to foster communication among Academic Medical Centers (AMCs) in the development of methods to improve clinical research management. The consortium, comprised of 46 awardee sites as of 2009, many with multiple AMCs, is expected to expand to 60 sites when fully implemented. At the 2nd Annual CTSA Clinical Research Management Workshop held on June 22nd and 23rd, 2009, on the National Institutes of Health (NIH) campus, consortium members and potential CTSA sites gathered with stakeholders from private industry, the NIH, the Food and Drug Administration, and private research organizations, to formulate a plan to address challenges in clinical research management. Specific aims included impr... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264031 Wed, 01 Dec 2010 00:00:00 +0100 4264031 http://www.medworm.com/index.php?rid=4264030&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00237.x AbstractThere is limited information on how academic institutions support effective mentoring practices for new investigators. A national semistructured telephone interview was conducted to assess current “state of the art” mentoring practices for KL2 scholars among the 46 institutions participating in the Clinical Translational Science Awards (CTSA) Consortium. Mentoring practices examined included: mentor selection, articulating and aligning expectations, assessing the mentoring relationship, and mentor training. Telephone interviews were conducted in winter/fall 2009, with 100% of the CTSAs funded (n= 46) through 2009, participating in the survey. Primary findings include: five programs selected mentors for K scholars, 14 programs used mentor contracts to define expectations, 16 pro... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264030 Wed, 01 Dec 2010 00:00:00 +0100 4264030 http://www.medworm.com/index.php?rid=4264029&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00243.x In this study, we attempted to correlate recurring mutations with the individuals’ ethnic origin. Specifically, we plotted our international database of 70 families from distinct or mixed ethnic backgrounds against their mutations. The frequent p.R1141X mutation was distributed widely across Europe, while deletion of exons 23–29 (del23–29) was encountered in Northern Europe and in Northern Mediterranean countries. p.R1138W may be a marker for French descent, evidenced by its presence also in French Canadians. The splice site transition mutation 3736–1G→A was seen in the neighboring countries Greece and Turkey, whereas 2542 delG occurs only in the Japanese. Two mutations seem to be present worldwide without evidence of a founder effect, p.Q378X and p.R1339C, suggesting the presenc... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264029 Wed, 01 Dec 2010 00:00:00 +0100 4264029 http://www.medworm.com/index.php?rid=4264028&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00249.x AbstractObtaining functional data with newly identified rare variants increases certainty that the variant identified is relevant for dilated cardiomyopathy (DCM) causation. Two novel SCN5A rare variants, R222Q and I1835T, segregated with DCM in two families with affected individuals homozygous or heterozygous for the common SCN5A polymorphism H558R. cDNAs with each rare variant were constructed in the common Q1077del or Q1077 splice variant backgrounds with and without the H558R polymorphism and expressed in HEK293 cells. Sodium current (INa) was studied for each using whole‐cell voltage clamp. In the Q1077del background INa densities of R222Q and I1835T were not different from wild type, but the combined variants of R222Q/H558R, I1835T/H558R caused approximately 35% and approximately 3... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264028 Wed, 01 Dec 2010 00:00:00 +0100 4264028 http://www.medworm.com/index.php?rid=4264027&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00242.x AbstractEssential hypertension (HBP) is a complex trait with a substantial heritable component. The purpose of this study was to determine if variants in the G‐protein coupled receptor Kinase‐4 (GRK4), nitric oxide synthase‐3 (NOS3), or angiotensin converting enzyme (ACE) genes are associated singly or through complex interactions, with HBP in African Americans aged 18–49 years. TaqMan Assays were used for genotyping the GRK4 and NOS3 variants. The ACE I/D variant was obtained by polymerase chain reaction and electrophoresis. Allelic association tests were performed for the five markers using PLINK. Logistic regression models were fitted to investigate associations between HBP status and the genetic markers. Multilocus analyses were also conducted. The study included 173 hypertensi... Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264027 Wed, 01 Dec 2010 00:00:00 +0100 4264027 http://www.medworm.com/index.php?rid=4264026&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00244.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264026 Wed, 01 Dec 2010 00:00:00 +0100 4264026 http://www.medworm.com/index.php?rid=4264025&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00234.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264025 Wed, 01 Dec 2010 00:00:00 +0100 4264025 http://www.medworm.com/index.php?rid=4264024&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00247.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264024 Wed, 01 Dec 2010 00:00:00 +0100 4264024 http://www.medworm.com/index.php?rid=4264023&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00235.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264023 Wed, 01 Dec 2010 00:00:00 +0100 4264023 http://www.medworm.com/index.php?rid=4264022&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00241.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4264022 Wed, 01 Dec 2010 00:00:00 +0100 4264022 http://www.medworm.com/index.php?rid=4104709&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00223.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104709 Thu, 30 Sep 2010 23:00:00 +0100 4104709 http://www.medworm.com/index.php?rid=4104708&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00221.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104708 Thu, 30 Sep 2010 23:00:00 +0100 4104708 http://www.medworm.com/index.php?rid=4104707&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00227.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104707 Thu, 30 Sep 2010 23:00:00 +0100 4104707 http://www.medworm.com/index.php?rid=4104706&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00217.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104706 Thu, 30 Sep 2010 23:00:00 +0100 4104706 http://www.medworm.com/index.php?rid=4104705&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00229.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104705 Thu, 30 Sep 2010 23:00:00 +0100 4104705 http://www.medworm.com/index.php?rid=4104704&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00232.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104704 Thu, 30 Sep 2010 23:00:00 +0100 4104704 http://www.medworm.com/index.php?rid=4104703&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00231.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104703 Thu, 30 Sep 2010 23:00:00 +0100 4104703 http://www.medworm.com/index.php?rid=4104702&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00226.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104702 Thu, 30 Sep 2010 23:00:00 +0100 4104702 http://www.medworm.com/index.php?rid=4104701&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00228.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104701 Thu, 30 Sep 2010 23:00:00 +0100 4104701 http://www.medworm.com/index.php?rid=4104700&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00218.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104700 Thu, 30 Sep 2010 23:00:00 +0100 4104700 http://www.medworm.com/index.php?rid=4104699&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00224.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104699 Thu, 30 Sep 2010 23:00:00 +0100 4104699 http://www.medworm.com/index.php?rid=4104698&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00219.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104698 Thu, 30 Sep 2010 23:00:00 +0100 4104698 http://www.medworm.com/index.php?rid=4104697&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00222.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104697 Thu, 30 Sep 2010 23:00:00 +0100 4104697 http://www.medworm.com/index.php?rid=4104696&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00209.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104696 Thu, 30 Sep 2010 23:00:00 +0100 4104696 http://www.medworm.com/index.php?rid=4104695&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00225.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104695 Thu, 30 Sep 2010 23:00:00 +0100 4104695 http://www.medworm.com/index.php?rid=4104694&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00230.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=4104694 Thu, 30 Sep 2010 23:00:00 +0100 4104694 http://www.medworm.com/index.php?rid=3880175&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00213.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880175 Sat, 31 Jul 2010 23:00:00 +0100 3880175 http://www.medworm.com/index.php?rid=3880174&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00202.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880174 Sat, 31 Jul 2010 23:00:00 +0100 3880174 http://www.medworm.com/index.php?rid=3880173&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00205.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880173 Sat, 31 Jul 2010 23:00:00 +0100 3880173 http://www.medworm.com/index.php?rid=3880172&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00206.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880172 Sat, 31 Jul 2010 23:00:00 +0100 3880172 http://www.medworm.com/index.php?rid=3880171&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00210.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880171 Sat, 31 Jul 2010 23:00:00 +0100 3880171 http://www.medworm.com/index.php?rid=3880170&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00203.x (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880170 Sat, 31 Jul 2010 23:00:00 +0100 3880170 http://www.medworm.com/index.php?rid=3880169&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00212.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880169 Sat, 31 Jul 2010 23:00:00 +0100 3880169 http://www.medworm.com/index.php?rid=3880168&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00211.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880168 Sat, 31 Jul 2010 23:00:00 +0100 3880168 http://www.medworm.com/index.php?rid=3880167&cid=s_38721_61_f&fid=38721&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1752-8062.2010.00220.x Abstract (Source: Clinical and Translational Science) Clinical and Translational Science journals http://www.medworm.com/rss/comments.php?id=3880167 Sat, 31 Jul 2010 23:00:00 +0100 3880167