MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinics in Dermatology' source. Tue, 02 Mar 2010 14:14:44 +0100 http://www.medworm.com/index.php?rid=3093832&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09002247%2Fabstract%3Frss%3Dyes Eleven years ago, one of the most prominent of Polish dermatologists, Prof Tadeusz Chorzelski, died. He was well known not only in his native country but also around the world. Best recognized for his research in immunodermatology, he was one of the founding fathers of this dermatologic subspecialty and one of the most productive research dermatologists of his time as well. Most of Prof Chorzelski's works can be described as original, innovative, and, in many instances, prophetic—providing new directions in the dermatologic sciences. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093832 Thu, 17 Dec 2009 14:02:33 +0100 3093832 http://www.medworm.com/index.php?rid=3093831&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000911%2Fabstract%3Frss%3Dyes The distinguishing feature of any profession is the nature of the oath or codes of conduct promulgated by the members. In the case of medicine, beginning with Hippocrates (ca 400 BCE), oaths taken by physicians to gods or a single god became important. To this day, some of the tenets of the Hippocratic Oath still guide us. Although nonmaleficence (primun non nocere) was an established concept credited to Hippocrates, it is not part of the oath. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093831 Thu, 17 Dec 2009 14:02:33 +0100 3093831 http://www.medworm.com/index.php?rid=3093830&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09002223%2Fabstract%3Frss%3Dyes The objectives set forth by the editors in the text's preface include providing an overview of the surgical aspects of dermatology while providing both a focused study guide for the dermatology resident and a convenient reference for the practicing physician. The authors manage to succeed in their collective endeavor, while maintaining a straightforward, concise style, and remaining surprisingly thorough, especially given the role and scope of this text within the greater Requisites series. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093830 Thu, 17 Dec 2009 14:02:33 +0100 3093830 http://www.medworm.com/index.php?rid=3093829&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000509%2Fabstract%3Frss%3Dyes The objectives of OLP management should be to prevent and screen for malignant transformation and alleviate symptoms on the long-term. Avoidance of potential precipitating drugs, tobacco, alcohol, and local trauma, as well as strict oral hygiene, is essential. The first-line pharmacologic treatment relies on topical steroids. Systemic steroids should be limited to the short-term cure of severe refractory OLP. Life-long clinical follow-up, at least annually, is fundamental. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093829 Thu, 17 Dec 2009 14:02:33 +0100 3093829 http://www.medworm.com/index.php?rid=3093828&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000625%2Fabstract%3Frss%3Dyes Abstract: Recommendations for changes in diet and lifestyle are not meant to supplant conventional therapy but to integrate with it and, hopefully, improve response to treatment. At the same time, integrative approaches permit the patient to depend less on more expensive and potentially harmful pharmaceutical and medical approaches. Manipulation of diet and lifestyle may actually diminish the effect of underlying predisposing or etiologic factors and simultaneously treat serious comorbidities. Topics include alcohol, smoking, body composition, sleep and stress, diet and nutrients, and exercise. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093828 Thu, 17 Dec 2009 14:02:32 +0100 3093828 http://www.medworm.com/index.php?rid=3093827&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000492%2Fabstract%3Frss%3Dyes Abstract: Cancer is one of the several comorbidities that have been linked with psoriasis. Not surprisingly, tumors associated with well-documented risk factors for the dermatosis, such as smoking and obesity, have been found with increased incidence in psoriatic patients. They include lung, kidney, and colon cancers. For unknown reasons, the risk of lymphoma is also increased in psoriatic patients. Despite several difficulties with documenting risks, some systemic treatments for psoriasis have been linked with an increased risk of selected cancers. The best-documented association is nonmelanoma skin cancer with psoralen plus ultraviolet A therapy and cyclosporin. More recently, an increased risk of cancer has been a concern with newly introduced biologic agents. The documentation of such ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093827 Thu, 17 Dec 2009 14:02:32 +0100 3093827 http://www.medworm.com/index.php?rid=3093826&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000480%2Fabstract%3Frss%3Dyes Abstract: During the last 30 years, the tremendous progress in our knowledge of the pathogenesis of psoriasis has led to the development of new agents, the so-called biologics, that have revolutionized the management of severe psoriasis. Dermatologists and patients see this emerging therapy as a new perspective in the state of the art in managing moderate to severe psoriasis. After a few years of use in daily practice, we may begin to analyze the power of the currently available biologic agents in the management of severe psoriasis from the perspective of facts. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093826 Thu, 17 Dec 2009 14:02:32 +0100 3093826 http://www.medworm.com/index.php?rid=3093825&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000893%2Fabstract%3Frss%3Dyes Discussion of these therapeutic modalities includes mode of use, indications, and unwanted effects. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093825 Thu, 17 Dec 2009 14:02:32 +0100 3093825 http://www.medworm.com/index.php?rid=3093824&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000479%2Fabstract%3Frss%3Dyes Abstract: Instruments to measure and to monitor the severity of psoriasis over time are needed for research and for optimal patient care. Scoring psoriasis has moved from an earlier time when clinical categories were adopted without concern about their reliability; for example, from clearance to more recent semi-quantitative scores, such as the Psoriasis Area and Severity Index (PASI), that carry the allure of being objective and quantitative “hard” data but actually translate a subjective judgement into a number. The PASI score has never been standardized, and data on interrater and intrarater reliability are limited. Better clinimetrics of disease severity are needed. The next generation of instruments should reflect the major concern of patients and treating physicians relative to s... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093824 Thu, 17 Dec 2009 14:02:32 +0100 3093824 http://www.medworm.com/index.php?rid=3093823&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0900090X%2Fabstract%3Frss%3Dyes Abstract: The pathophysiology of atopic dermatitis is still under discussion. Although it is widely accepted that environmental factors and a genetic predisposition are essential, the role of the innate and adaptive immune system and the functional cascade of the cells involved is still unclear. A concept that integrates all immune cells as equally essential has allure. In addition, barrier abnormalities due to mutations of the gene coding for filaggrin and down-regulation of antimicrobial peptides, such as LL-37 and β-defensins 2 and 3, were very recently found to be relevant for the pathogenesis of atopic dermatitis. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093823 Thu, 17 Dec 2009 14:02:32 +0100 3093823 http://www.medworm.com/index.php?rid=3093822&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000637%2Fabstract%3Frss%3Dyes Abstract: The term complementary or alternative medicine encompasses numerous diverse therapeutic concepts, ranging from as herbal medicine, diet with essential fatty acids, and probiotics, to acupuncture. The main focus of these treatment methods is inflammatory skin disease, in particular atopic dermatitis. Although integrative medicine enjoys increasing popularity, particularly in industrialized countries, clinical studies that meet the double-blind, placebo-controlled standard are rare or nonexistent. The aim of this contribution is to provide the various concepts of integrative medicine. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093822 Thu, 17 Dec 2009 14:02:32 +0100 3093822 http://www.medworm.com/index.php?rid=3093821&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0900087X%2Fabstract%3Frss%3Dyes Abstract: Topical calcineurin inhibitors have developed a bad connotation because of a black-box warning that was based on safety concerns of hypothetic systemic absorption and because systemic treatment with calcineurin inhibitors in patients who receive organ transplants is associated with an increased cancer risk. A few case reports of lymphoma and skin cancer in patients treated with topical calcineurin inhibitors initiated the discussion. These drugs were recommended for use as second-line therapy for the short-term and noncontinuous treatment of atopic dermatitis in patients who do not respond adequately to topical corticosteroids or in whom they are contraindicated. According to the latest knowledge, there is no scientific evidence of an increased risk for malignancy due to a topica... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093821 Thu, 17 Dec 2009 14:02:32 +0100 3093821 http://www.medworm.com/index.php?rid=3093820&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000558%2Fabstract%3Frss%3Dyes Abstract: The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiologic factors, including the epidermal barrier, the digestive flora, food, early infections and antigenic stimulations, and innate and adaptive immune response; however, overfocusing on some of these factors, along with misconceptions about the benefit/risk balance of topical therapies, has sometimes led topical therapies being disregarded. Reviewing the history of pathophysiologic concepts, we aim to return topical therapies to the center of the clinical management of ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093820 Thu, 17 Dec 2009 14:02:32 +0100 3093820 http://www.medworm.com/index.php?rid=3093819&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000546%2Fabstract%3Frss%3Dyes Abstract: We conducted a systematic Medline search of the literature (1998-2008) on the criteria for performing the skin prick test and atopy patch testing (APT) to determine their utility in atopic dermatitis (AD). The skin prick, scratch, and skin patch tests are performed to identify which allergen is causing eczematous skin symptoms in patients with AD, or sneezing, nasal congestion, itchy eyes, wheezing, skin rash, and swelling. Many allergens in foods, drugs, and environmental substances (eg, ragweed and fungus), as well as contact allergens, can elicit eczematous skin reactions after epicutaneous application. Because no gold standard exists for aeroallergen provocation in AD, the APT is currently used to evaluate allergen without comparison with another accurate and reliable method.... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093819 Thu, 17 Dec 2009 14:02:32 +0100 3093819 http://www.medworm.com/index.php?rid=3093818&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000534%2Fabstract%3Frss%3Dyes Abstract: Conventional wisdom posits that breastfeeding during the first 4 months of life generally reduces the incidence of atopic dermatitis in the child. Recent studies question this truism, especially in cases when the mother herself is allergic. Studies about maternal dietary allergens in breast milk and their influence on atopic dermatitis have been questioned as well. There is evidence that probiotic and essential fatty acid supplementation, along with an allergen-avoidance diet, may reduce the chance of maternal dietary allergens provoking atopic dermatitis in the infant. Evidence on both sides of the controversy is presented in an effort to produce meaningful guidelines for breastfeeding infants at risk for atopic dermatitis. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093818 Thu, 17 Dec 2009 14:02:32 +0100 3093818 http://www.medworm.com/index.php?rid=3093817&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000881%2Fabstract%3Frss%3Dyes Abstract: It has long been known that light is helpful in acne. Teens recognize that summer sun diminishes pimples, and wise pharmaceutical companies (which is limiting) know that a drug trial ending in sunny months will have an elevated placebo response. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093817 Thu, 17 Dec 2009 14:02:31 +0100 3093817 http://www.medworm.com/index.php?rid=3093816&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000510%2Fabstract%3Frss%3Dyes Abstract: Acne is one of the most prevalent diseases in dermatology: Millions of people worldwide experience this distressing condition. To determine the appropriate therapeutic strategy, there is a strong need for a standardized classification system of acne. The exact molecular mechanism of action of isotretinoin is not completely understood; however, oral isotretinoin targets simultaneously at all major mechanisms of acne pathogenesis. Various mass media reports about the risk of teratogenicity and depression from isotretinoin usage as well as the creation of intense prevention programs have created an obstacle to the use of the most active available drug against acne, presenting isotretinoin as a very dangerous regimen. According to recommendations of several international experts, whi... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093816 Thu, 17 Dec 2009 14:02:31 +0100 3093816 http://www.medworm.com/index.php?rid=3093815&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000522%2Fabstract%3Frss%3Dyes We describe the hormonal agents currently available for acne treatment, discuss their indications and contraindications, and address the question of whether they may be used as a first-line therapy in acne. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093815 Thu, 17 Dec 2009 14:02:31 +0100 3093815 http://www.medworm.com/index.php?rid=3093814&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0900056X%2Fabstract%3Frss%3Dyes Abstract: Acne is the most prevalent skin condition. It has a substantial effect on the quality of life of teenagers worldwide. Among acne patients from different societies and cultures, diet is uniformly regarded as a major cause in the pathogenesis of acne. We reviewed the up-to-date literature regarding acne and culprit foods such as dairy products, chocolate, and fatty foods. Unfortunately, after reviewing the existing data, there are no answers but there are definitely more questions, because there is no clear proof about whether these issues are facts or misconceptions. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093814 Thu, 17 Dec 2009 14:02:31 +0100 3093814 http://www.medworm.com/index.php?rid=3093813&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000571%2Fabstract%3Frss%3Dyes Abstract: Increased sebum secretion has been known as one of the major pathogenic factors in the development of acne; however, objective sebum measurement methods have been developed only recently. We have limited information about the association of sebum secretion, and the development of acne. There continues to be controversy about the role of sebum in the development of acne. This contribution will discuss sebum measurement techniques and the results of recent studies on the relationship of sebum, facial cosmetic skin type, and acne. New therapeutic modalities for inflammatory acne aim to control seborrhea. Superficial chemical peels, laser treatment for inflammatory acne, and photodynamic therapy are used as adjunctive therapies for acne; however, their sebosuppressive effects are onl... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093813 Thu, 17 Dec 2009 14:02:31 +0100 3093813 http://www.medworm.com/index.php?rid=3093812&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000583%2Fabstract%3Frss%3Dyes Abstract: We have come a long way since 1896, when it was first suggested that Propionibacterium acnes, found in acne lesions, was the cause of acne. Although several lines of evidence suggest the direct role of P acnes in acne, the mechanism by which P acnes contributes to the pathogenesis of acne is debated. The importance of P acnes in the induction and maintenance of the inflammatory phase of acne has been established. Emerging data that inflammatory events occur in the very earliest stages of acne development have reopened the debate about the potential involvement of this microorganism in comedogenesis and acne initiation. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093812 Thu, 17 Dec 2009 14:02:31 +0100 3093812 http://www.medworm.com/index.php?rid=3093811&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000595%2Fabstract%3Frss%3Dyes When a thing ceases to be a subject of controversy, it ceases to be a subject of interest.William Hazlitt (1778-1830), British essayist. Medicine is a dynamic discipline, and many medical diagnostic and therapeutic procedures come and go within the span of only a few years. Those changes are always accompanied by different opinions, controversies, and disagreements: Indeed, controversy has always played a pivotal role in the history of medicine. That is one of the few features that has neither changed with time nor can it be disputed! (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093811 Thu, 17 Dec 2009 14:02:31 +0100 3093811 http://www.medworm.com/index.php?rid=3093810&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09002302%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093810 Thu, 17 Dec 2009 14:02:31 +0100 3093810 http://www.medworm.com/index.php?rid=3093809&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09002272%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3093809 Thu, 17 Dec 2009 14:02:31 +0100 3093809 http://www.medworm.com/index.php?rid=2951925&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000613%2Fabstract%3Frss%3Dyes After the wedding we made our first home in a little flat located in a new area, finding a new church and new friends, just like many other young couples that we knew. We were so excited at the birth of our first son in 1968, although noticing that he seemed to be very long – totally filling the crib – and that he had very long slim arms, legs, fingers and toes – and absolutely huge feet! As I breastfed him I remember not quite knowing how to hold him as he seemed to be so big and I, at that time, was very petite! His eyes were beautiful, very bright, and we were absolutely thrilled with the new addition to our family. Such lovely soft skin, maybe a little opaque. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951925 Sun, 01 Nov 2009 00:00:00 +0100 2951925 http://www.medworm.com/index.php?rid=2951924&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001552%2Fabstract%3Frss%3Dyes Physicians, and more particularly dermatologists, have always had a bent for discovering the strange and uncommon. Witness the century-old book by Gould and Pyle, Anomalies and Curiosities of Medicine, where the unusual to the macabre are presented, ranging from Duhring's bearded woman to various Siamese twins. More recently, Bondeson gathered additional curiosities in his volume, A Cabinet of Medical Curiosities, such as the two-headed boy of Bengal and the infamous Mary Toft who claimed to have given birth to rabbits. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951924 Sun, 01 Nov 2009 00:00:00 +0100 2951924 http://www.medworm.com/index.php?rid=2951923&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001971%2Fabstract%3Frss%3Dyes Abstract: The incidence of melanoma is increasing, and the therapeutic options for unresectable disease are limited, resulting in an increase in the death rate. Melanoma is usually resistant to standard chemotherapy, and the response rate for any single agent or combination of agents is 15% to 25%. High-dose interleukin-2 results in prolonged responses in a minority of patients, and biochemotherapy (combinations of chemotherapy, interferon, and interleukin-2) is associated with an improved response rate, but no clear effect on overall survival. A number of promising new agents have entered clinical trials in recent years, including monoclonal antibodies and small molecule inhibitors that target either the malignant melanocytes or negative regulators of the immune system. These drugs appear... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951923 Sun, 01 Nov 2009 00:00:00 +0100 2951923 http://www.medworm.com/index.php?rid=2951922&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0800196X%2Fabstract%3Frss%3Dyes Abstract: Melanoma cells can play a number of tricks to evade the host immune response. They can make themselves invisible to cells of the immune system poised to attack them, elaborate molecules that are frankly immunosuppressive, and can create a microenvironment that is hostile to cells of the immune system. Efforts are underway to institute measures that would make tumor cells more susceptible to immune attack, but these efforts have not been all that successful so far. This contribution reviews the history and the rationale of cancer vaccines, the major obstacles to peptide-based immunization, and a discussion on how to surmount them. Also included are the roles played by peripheral tolerance, low-affinity T-cell receptors, T-cell ignorance, activation-induced cell death, exhaustion o... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951922 Sun, 01 Nov 2009 00:00:00 +0100 2951922 http://www.medworm.com/index.php?rid=2951921&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001958%2Fabstract%3Frss%3Dyes Abstract: Mohs micrographic surgery (MMS) is very successful in the treatment of nonmelanoma skin cancer. Examining 100% of the margin using MMS improves cure rates. This method has obvious appeal in treating melanoma. Evaluating the lateral margins of melanomas using frozen tissue sections is complicated. Some studies have shown that basic frozen sections can be accurate in margin evaluation, but others have shown that they are unreliable. The use of immunostains on frozen sections is one method that may make the analysis of frozen sections more accurate. Other modifications, including the use of rush paraffin sections in lieu of frozen sections, “slow Mohs,” have also been reported. Although the role of MMS in the treatment of melanoma has been controversial, multiple reports using a... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951921 Sun, 01 Nov 2009 00:00:00 +0100 2951921 http://www.medworm.com/index.php?rid=2951920&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001946%2Fabstract%3Frss%3Dyes Abstract: Sentinel lymph node biopsy has greatly influenced the surgical management of clinically localized primary melanoma. Lymphatic mapping and sentinel lymph node biopsy have been used for the selective management of the draining regional lymph node basin of primary cutaneous melanoma. Oncologic surgeons have adopted this procedure to selectively identify occult nodal status in melanoma patients who are at a higher risk of regional metastasis. The current standard of treatment of tumor-positive sentinel lymph node metastasis is immediate completion lymphadenectomy, but considerable debate surrounds the utility of this procedure. This contribution reviews development, technical aspects, selective management of the lymph node basin, and sentinel lymph node biopsy techniques. (Source: Cl... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951920 Sun, 01 Nov 2009 00:00:00 +0100 2951920 http://www.medworm.com/index.php?rid=2951919&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001934%2Fabstract%3Frss%3Dyes Abstract: The sentinel lymph node biopsy has taught us important lessons about the behavior of melanoma and, perhaps, of melanocytic nevi. It is of proven prognostic importance in patients whose diagnosis of melanoma is clear-cut. Sentinel lymph node biopsy is an imperfect prognostic tool, however, and although the morbidity of the procedure is low, completion lymphadenectomy has a high morbidity rate and unproven benefit. In the setting of a borderline lesion, small nodal deposits must be interpreted with caution. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951919 Sun, 01 Nov 2009 00:00:00 +0100 2951919 http://www.medworm.com/index.php?rid=2951918&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001922%2Fabstract%3Frss%3Dyes Abstract: Melanoma is as diverse in its presentation as it can be in its behavior. This contribution will review the clinical and histologic features of some of the more unusual variants of malignant melanoma that clinicians and pathologists are likely to encounter. There will be a disproportionate focus on the histopathology and prognosis because the clinical presentation of these lesions is in most cases, elusive, and in some cases, frankly deceptive. The discussion will include desmoplastic melanoma, nevoid melanoma, spitzoid melanoma, angiotropic melanoma, and malignant blue nevus. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951918 Sun, 01 Nov 2009 00:00:00 +0100 2951918 http://www.medworm.com/index.php?rid=2951917&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001910%2Fabstract%3Frss%3Dyes Abstract: Acral lentiginous melanoma of the foot is a relatively rare but often very aggressive variant of melanoma. More commonly identified in patients with darker skin, diagnosis of the lesions is often delayed because the area is not routinely examined by patients or primary care physicians. In addition, these lesions often mimic other entities, including vascular lesions and infections. Greater awareness of this entity and performing appropriate biopsies will result in more timely diagnoses and improved survival. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951917 Sun, 01 Nov 2009 00:00:00 +0100 2951917 http://www.medworm.com/index.php?rid=2951916&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001909%2Fabstract%3Frss%3Dyes Abstract: Because spitzoid melanoma shares many histopathologic features with Spitz nevus, it is one of the most difficult lesions to diagnose in dermatopathology. Uncertainty exists in the medical literature about how to diagnose melanocytic proliferations including Spitz nevus and spitzoid melanoma. A misdiagnosis of a melanoma as Spitz nevus is one of the most frequent causes of malpractice lawsuits in surgical pathology and dermatopathology. This contribution provides a review of the clinical presentation, histopathology, ancillary studies, treatment, and the differential diagnosis of spitzoid melanoma. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951916 Sun, 01 Nov 2009 00:00:00 +0100 2951916 http://www.medworm.com/index.php?rid=2951915&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001892%2Fabstract%3Frss%3Dyes Abstract: The rapidly expanding segment of the aging population with its rising incidence of cutaneous melanoma will present major challenges in therapeutic management. Immune strategies will be important in designing effective treatment of melanoma because it is a highly immunogenic tumor. Aging, however, is associated with dysregulation of the immune system and is likely to affect the success of melanoma treatment in the elderly population. This population represents an ideal in vivo model to study the effects of the aging immune system on the natural history of melanoma in the elderly. We review the epidemiology, histopathologic features, and treatment outcomes of elderly melanoma patients with reference to their immune function. Various components of the normal immune system are descri... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951915 Sun, 01 Nov 2009 00:00:00 +0100 2951915 http://www.medworm.com/index.php?rid=2951914&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08001880%2Fabstract%3Frss%3Dyes Abstract: Pediatric melanoma is rare but increasing in incidence. Because early diagnosis and treatment improves prognosis, clinicians need to include it as a possible diagnosis when evaluating a pigmented lesion in a pediatric patient. Some risk factors for melanoma include xeroderma pigmentosum, giant congenital melanocytic nevi, dysplastic nevus syndrome, atypical nevi, many acquired melanocytic nevi, family history of melanoma, and immunosuppression. Definitive treatment is with surgical excision. Adjuvant therapies such as chemotherapy, immunotherapy, and radiation therapy can be used in advanced cases. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951914 Sun, 01 Nov 2009 00:00:00 +0100 2951914 http://www.medworm.com/index.php?rid=2951913&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002149%2Fabstract%3Frss%3Dyes Those of us who read journals like the Wall Street Journal are aware that the public craves medical information. Despite this fact and the fact that athletes (Troy Aikman, Dallas Cowboy quarterback), musicians (Danny Federici, drummer for Bruce Springsteen's band, and Bob Marley, both of whom died of melanoma), news reporters (Sam Donaldson), actors (Ewan MacGregor), and politicians and their families (Maureen Reagan and John McCain) have gone public about their melanomas, much of the population are still visiting tanning parlors, sunbathing and burning on the beaches, and not getting regular cutaneous examinations. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951913 Sun, 01 Nov 2009 00:00:00 +0100 2951913 http://www.medworm.com/index.php?rid=2951912&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001825%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951912 Sun, 01 Nov 2009 00:00:00 +0100 2951912 http://www.medworm.com/index.php?rid=2951911&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001795%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2951911 Sun, 01 Nov 2009 00:00:00 +0100 2951911 http://www.medworm.com/index.php?rid=2713893&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001370%2Fabstract%3Frss%3Dyes In the July/August 2009 issue of Clinics in Dermatology (volume 27, issue 4, pages 355-8), the name of the senior author should have read: Mari Paz Castanedo-Tardan, MD. The editors regret any confusion this may have caused. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713893 Thu, 20 Aug 2009 10:16:03 +0100 2713893 http://www.medworm.com/index.php?rid=2713892&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001357%2Fabstract%3Frss%3Dyes Charles Hilton Fagge () was born on June 30, 1838, at Hythe in Kent, England, to a family with a medical tradition. His maternal uncle, John Hilton (1804-1878), was an anatomist and surgeon, President of the Royal College of Surgeons, and surgeon extraordinary to Queen Victoria. His father, Charles Fagge, and his grandfather were also physicians. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713892 Thu, 20 Aug 2009 10:16:03 +0100 2713892 http://www.medworm.com/index.php?rid=2713891&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000601%2Fabstract%3Frss%3Dyes Mrs. Jones was jaundiced and her abdomen was distended. On the left side of her chest, there was a 7/8th inch high blue-black blurry tattoo, O+ (). What was the story behind this tattoo, 53 years old, and placed when the patient was 7 years old? She told me the symbol represented her blood type. She had stood in line together with her class mates. First, her blood was taken with a small prick, and then the tattoo gun pierced her side with pain! Children around her were crying, and some were hiding. The cause was worthy, so her parents had not refused. Her diagnosis was cryptogenic cirrhosis, but what if she really had hepatitis C? (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713891 Thu, 20 Aug 2009 10:16:03 +0100 2713891 http://www.medworm.com/index.php?rid=2713890&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001345%2Fabstract%3Frss%3Dyes Starting out in dermatology as a resident (S.P.), delving into the field and learning about dermatologic diseases can be a daunting task. Although there are numerous texts to study, General Dermatology provides an excellent foundation upon which to build (). The book is divided into 25 chapters. Each topic is presented in a clear and organized fashion, starting with clinical presentation, pathogenesis, and diagnosis, and ending with laboratory testing and treatment. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713890 Thu, 20 Aug 2009 10:16:03 +0100 2713890 http://www.medworm.com/index.php?rid=2713889&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0900131X%2Fabstract%3Frss%3Dyes Abstract: In response to consumer and patient demands for the newest, clinically proven technologies, physicians are increasingly developing and patenting their own products. Patented technologies come in many forms from new bioengineered molecules, to new uses of old compounds, to multiple ingredient complexes that work synergistically. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713889 Thu, 20 Aug 2009 10:16:03 +0100 2713889 http://www.medworm.com/index.php?rid=2713888&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001308%2Fabstract%3Frss%3Dyes Abstract: Despite several technologic and strategic advances in the field, wound care has returned to the roots of medicine and embraced some of the remedies used millennia ago. Some of the many potentially beneficial natural products include the β-glucans, honey, aloe, cocoa, and oak bark extracts. There has recently been a surge of interest for their possible roles in wound healing. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713888 Thu, 20 Aug 2009 10:16:03 +0100 2713888 http://www.medworm.com/index.php?rid=2713887&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001564%2Fabstract%3Frss%3Dyes Abstract: The hydroxyacids are represented by the α-hydroxyacids, β-hydroxyacids, polyhydroxy acids, and bionic acids. Together, these ingredients form a class of compounds with unparalleled benefits to the skin and unprecedented usage in the cosmeceutical market in cosmetic and therapeutic formulations alike. The most commonly used hydroxyacid is glycolic acid, an α-hydroxyacid that has been used extensively in cosmetic antiaging formulations, moisturizers, and peels, and in treatment products to improve hyperpigmentation and acne. The newer polyhydroxy and bionic acids offer the benefits of α-hydroxyacids without irritation, making them suitable for use on sensitive skin, rosacea, and after cosmetic procedures. They also provide additional antioxidant/chelation, barrier strengthening... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713887 Thu, 20 Aug 2009 10:16:02 +0100 2713887 http://www.medworm.com/index.php?rid=2713886&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0900128X%2Fabstract%3Frss%3Dyes Abstract: In nature, the majority of chemical reactions, biological responses, and regulatory processes are modulated in some part by specific amino acid sequences. The transfer of these interactive sequences and the biological activities they induce to short, stable, and readily synthesized peptides has created a diverse new field of modulating molecules applicable to dermatology and skin care industries. Areas such as inflammation, pigmentation, cell proliferation and migration, angiogenesis, innate immunity, and extracellular matrix synthesis have yielded peptide candidates for application to this area. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713886 Thu, 20 Aug 2009 10:16:02 +0100 2713886 http://www.medworm.com/index.php?rid=2713885&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001278%2Fabstract%3Frss%3Dyes Abstract: Cosmeceuticals are used for nourishing and improving the appearance of the skin and are also documented as effective agents for treating various dermatologic conditions. Cosmeceutical preparations from herbal origin are most popular among consumers because these agents are mostly nontoxic and possess strong antioxidant activity. Because oxidative stress is one of the major mechanisms for skin aging and dermatologic conditions, phytochemicals with proven antioxidant activity, such as silibinin, could be useful for treating many dermatologic conditions as well as skin aging. Silibinin is a flavonolignan compound from Silybum marianum (milk thistle plant) that possesses strong antioxidant activity and also modulates many molecular changes caused by xenobiotics and ultraviolet radiat... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713885 Thu, 20 Aug 2009 10:16:02 +0100 2713885 http://www.medworm.com/index.php?rid=2713884&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001266%2Fabstract%3Frss%3Dyes Abstract: Phenolic compounds found in plants are believed to be effective in prevention of oxidative stress related diseases. An interest in antioxidants and natural foods continues to grow along with a commercial interest in plant-derived phenolic products. Flavonoids represent a family of plant compounds high in phenolic related antioxidant activity. They are poorly absorbed in the body. Many published studies show the antioxidant activity of the flavonoid, but fail to consider the activity of the metabolite which is actually bioavailable to the body. The paper concludes that there remains a need to develop adequate physiological models supporting antioxidant activity of polyphenols. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713884 Thu, 20 Aug 2009 10:16:02 +0100 2713884 http://www.medworm.com/index.php?rid=2713883&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001254%2Fabstract%3Frss%3Dyes Abstract: The term cosmeceutical was created over 25 years ago to define products with active substances that cannot be considered cosmetics or drugs. Cosmeceuticals are increasingly popular, with sales representing one of the largest growing segments of the skin care market. These products are found in many forms, including vitamins, peptides, growth factors, and botanical extracts. Cosmeceuticals that contain topically applied vitamins have an increasing role in skin care. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713883 Thu, 20 Aug 2009 10:16:02 +0100 2713883 http://www.medworm.com/index.php?rid=2713882&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001242%2Fabstract%3Frss%3Dyes Abstract: Cosmetic ingredients previously considered “inert” have potential to provide a biologic effect to skin. In a cosmeceutical formulation, the boundary between an “active” and “inert” ingredient may be obscured. For this reason, the cosmeceutical distributor must find a nonambiguous method to demonstrate the efficacy of a new ingredient. For a product to be successful in the marketplace, the benefits of the product must clearly be communicated to the consumer, and the consumer must be satisfied with product performance. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713882 Thu, 20 Aug 2009 10:16:02 +0100 2713882 http://www.medworm.com/index.php?rid=2713881&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001229%2Fabstract%3Frss%3Dyes Abstract: Consumers will pay a premium for high-performance skin and hair care products. The demand exists, and in return for the high cost, consumers expect the product to perform as claimed and to meet aesthetic standards beyond many products found in the mass market. To be successful in this highly competitive market, products must function as claimed or consumers will not repurchase. Effective contemporary high-end products must be properly formulated in nonirritating vehicles that consumers will perceive as elegant. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713881 Thu, 20 Aug 2009 10:16:02 +0100 2713881 http://www.medworm.com/index.php?rid=2713880&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001230%2Fabstract%3Frss%3Dyes Abstract: Cosmeceuticals, or physiologically active cosmetics, are subject to many misconceptions. Most consumers mistakenly believe that cosmeceuticals are regulated and tested as drugs. They also believe that the ingredients and final products have been tested for safety and that the claims made in advertisements are valid. Although cosmeceuticals and pharmaceutical ingredients have never been closer together, their regulatory environments are vastly different due to the distinct Congressional mandates given the Food and Drug Administration. Physicians are in a good position to help patients and potential cosmeceutical users understand the benefits and realistic limitations of these products. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713880 Thu, 20 Aug 2009 10:16:02 +0100 2713880 http://www.medworm.com/index.php?rid=2713879&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001217%2Fabstract%3Frss%3Dyes Abstract: In the cosmetic arena, many materials are used commercially and claim to provide skin effects (eg, antiaging effects) when used topically. Considering there are so many such materials and many skin appearance effects are encompassed, this short contribution must, by necessity, be selective in terms of the number of materials discussed and the depth with which any particular material is overviewed. This presentation, therefore, focuses on only 10 types of cosmeceutical agents: five vitamins (A, B3, C, E, panthenol), peptides, hydroxyl acids, sugar amines, ceramides, and metals. In particular, this contribution concentrates on those materials for which there are available clinical data that support a reported skin appearance improvement effect. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713879 Thu, 20 Aug 2009 10:16:02 +0100 2713879 http://www.medworm.com/index.php?rid=2713878&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001205%2Fabstract%3Frss%3Dyes Abstract: The cosmeceutical category is an undefined, unclassified, and unregulated area of dermatology that is yet in its infancy. Traditional cosmeceuticals involve the topical application of biologically active ingredients that affect the skin barrier and overall skin health. The ability of these ingredients to enhance skin functioning depends on how they are formulated into products that can maintain the integrity of the active ingredient, deliver it in a biologically active form to the skin, reach the target site in sufficient quantity to exert an effect, and properly release from the carrier vehicle. In the United States, cosmeceuticals are sold as cosmetics, making marketing, packaging, and aesthetic appeal important considerations. Ideally, the cosmeceutical should be clinically te... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713878 Thu, 20 Aug 2009 10:16:02 +0100 2713878 http://www.medworm.com/index.php?rid=2713877&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001199%2Fabstract%3Frss%3Dyes Abstract: Four major categories of interest in the cosmeceutical market are nonbleaching agents, antioxidants, peptides, and growth factors. The trend toward introducing natural products considered to be safe is influenced by media hype and consumer interest. This is driving the cosmeceutical market to develop safer products that are naturally derived. Some of these naturally derived products have proven to be helpful, whereas more evidence is needed for other products before physicians can consider recommending their use. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713877 Thu, 20 Aug 2009 10:16:02 +0100 2713877 http://www.medworm.com/index.php?rid=2713876&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001187%2Fabstract%3Frss%3Dyes More than 4 decades have passed since the term “cosmeceutical” was introduced. The term continues to be ambiguous today, as it was then. It is generally accepted that a cosmeceutical is a material that will not harm the individual and may indeed be beneficial. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713876 Thu, 20 Aug 2009 10:16:01 +0100 2713876 http://www.medworm.com/index.php?rid=2713875&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001631%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713875 Thu, 20 Aug 2009 10:16:01 +0100 2713875 http://www.medworm.com/index.php?rid=2713874&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001606%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2713874 Thu, 20 Aug 2009 10:16:01 +0100 2713874 http://www.medworm.com/index.php?rid=2488383&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08000783%2Fabstract%3Frss%3Dyes Skin diseases frequently are portrayed in cinema, perhaps second only to movies, including psychological and psychiatric subject matter. Plots involving issues of the mind and skin may be attractive to film makers due to the seeming ease of depiction in film. Viewers cannot, of course, directly see the thoughts of film characters, but character speech, behavior, and interactions with other characters allow the audience to vicariously experience portrayals of psychological and psychiatric conditions. Psychologists and psychiatrists have analyzed films with behavioral content that contain topics about which they are expert, critiquing artistic depictions of mental disorders for accuracy and using movies to teach others about the profound personal and societal impact of mental illness. Dermat... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488383 Thu, 25 Jun 2009 07:32:21 +0100 2488383 http://www.medworm.com/index.php?rid=2488382&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0800223X%2Fabstract%3Frss%3Dyes It has been said that if you would be remembered, do something worth remembering. I have had the privilege of reviewing a new reference work about those who have made great contributions in dermatology and are very much worth remembering. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488382 Thu, 25 Jun 2009 07:32:21 +0100 2488382 http://www.medworm.com/index.php?rid=2488381&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000364%2Fabstract%3Frss%3Dyes Abstract: Most graduating medical students will take some sort of oath that is to inspire them to take their proper place in the comradeship of physicians and remind them of their obligations to their patients, society, and their profession. The nature of these oaths has changed over the years as society itself has changed. What may be considered moral, ethical, or legal at one time can appear quaint or outrageous in another time and place. Several classic and newer oaths can be compared and contrasted in what they are tasking the newly minted physician to do. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488381 Thu, 25 Jun 2009 07:32:21 +0100 2488381 http://www.medworm.com/index.php?rid=2488380&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000352%2Fabstract%3Frss%3Dyes Abstract: The Accreditation Council for Graduate Medical Education and the Royal College of Physicians and Surgeons of Canada both require the teaching and demonstration of general competencies, which include professionalism and ethics as a condition of training program accreditation and specialty certification, respectively. Residents in dermatology and other specialties perceive their training in ethics is inadequate in numerous areas. Residents and specialists in dermatology encounter numerous ethical and professional issues throughout their workday. A dermatoethics curriculum was developed at The Warren Alpert Medical School of Brown University in 2001 to address the need for training in bioethics and professionalism. The subject matter of the curriculum and didactic methods are review... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488380 Thu, 25 Jun 2009 07:32:21 +0100 2488380 http://www.medworm.com/index.php?rid=2488379&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000340%2Fabstract%3Frss%3Dyes Abstract: As the number of uninsured and underinsured American citizens increases, there is new interest in developing some sort of national health plan to ensure what many consider a basic right in industrialized countries. The debate is no longer merely between the “socialized medicine” advocates and those who believe the government should stay completely out of health care delivery. Now between those who agree that some sort of national health plan is necessary, there is conflict between the “incrementalists” and the “revolutionists,” who have differing ideas on how to best expand health care access to those without. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488379 Thu, 25 Jun 2009 07:32:21 +0100 2488379 http://www.medworm.com/index.php?rid=2488378&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000339%2Fabstract%3Frss%3Dyes Abstract: Many professional societies, along with official government missions and nongovernmental organizations, currently work to provide health care and medical education in developing countries and other underserved areas. Before interested physicians volunteer, they must make sure that they are emotionally, physically, and logistically prepared to provide useful assistance. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488378 Thu, 25 Jun 2009 07:32:21 +0100 2488378 http://www.medworm.com/index.php?rid=2488377&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000315%2Fabstract%3Frss%3Dyes Abstract: The advancement of medical science has come, at times, at the expense of patient comfort and dignity. Over the years, guidelines for human experimentation have become more defined and regulated, often after events in which researchers egregiously abused or neglected their subjects. From this specialty's very beginning, dermatologists have also been guilty of crossing these lines of professional behavior and ethics. Questionable studies sponsored and performed by some of dermatology's most esteemed names continued even into the late 20th century. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488377 Thu, 25 Jun 2009 07:32:21 +0100 2488377 http://www.medworm.com/index.php?rid=2488376&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000327%2Fabstract%3Frss%3Dyes Abstract: The system in place to ensure the ethical conduct of human subject research in accordance with federal regulations has drawn great criticism from all sides, to include clinical investigators, administrators, research subjects, and legislators. The administrative requirements associated with clinical trials has changed dramatically in the last several decades, as has the complexity of the science being regulated. The institutional review board (IRB) system, however, appears to be struggling to keep pace, and has even been labeled a “system in jeopardy” by a national committee of experts. This contribution outlines the current obstacles and critique of IRBs, providing a discussion of the structure of the IRB system and strategies to meet these challenges. (Source: Clinics in De... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488376 Thu, 25 Jun 2009 07:32:21 +0100 2488376 http://www.medworm.com/index.php?rid=2488375&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000303%2Fabstract%3Frss%3Dyes Abstract: It is ethical, legal, and proper for a dermatologist to maximize income through proper coding of patient encounters and procedures. The overzealous physician can misinterpret reimbursement requirements or receive bad advice from other physicians and cross the line from aggressive coding to coding fraud. Several of the more common problem areas are discussed. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488375 Thu, 25 Jun 2009 07:32:21 +0100 2488375 http://www.medworm.com/index.php?rid=2488374&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000297%2Fabstract%3Frss%3Dyes Abstract: Teledermatology is the use of telecommunication for medical diagnosis and patient care in dermatology. The visual nature of diagnosis in dermatology makes it particularly well suited to the practice of telemedicine. The differences between the two basic types of teledermatology, real-time and store-and-forward, are reviewed. Case scenarios are used to examine some of the ethical and clinical issues that can occur, such as the nature of the doctor-patient relationship, follow-up of incidental diagnoses, limitations of telemedicine, privacy issues, and licensing. Guidelines for the use of telemedicine in dermatology are reviewed. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488374 Thu, 25 Jun 2009 07:32:21 +0100 2488374 http://www.medworm.com/index.php?rid=2488373&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000285%2Fabstract%3Frss%3Dyes Abstract: As Internet access has become ubiquitous, electronic mail (e-mail) is becoming more widely used as a means of communication between patient and dermatologist. Dealing with the ethical, legal, and clinical consequences has lagged behind the technology. Privacy of e-mail cannot exist without security, and as a foundation for understanding e-mail security, the elements of e-mail technology are reviewed. One of the greatest risks of e-mail is compromise of privacy. Although self-documenting and convenient, e-mail lacks the emotional cues of face-to-face encounters, is asynchronous and not always read in timely fashion, and is not suitable for certain clinical concerns such as urgent matters and cancer diagnoses. Legal issues relating to federal privacy regulations, ethical issues suc... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488373 Thu, 25 Jun 2009 07:32:21 +0100 2488373 http://www.medworm.com/index.php?rid=2488372&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000273%2Fabstract%3Frss%3Dyes Abstract: One of the most controversial topics surrounding the practice of dermatology is in-office dispensing of nonprescription skin care products by dermatologists. The controversy is not new, with legitimate arguments debated for and against it. The ongoing debate will continue, emotionally charged and with sharply demarcated battle lines, but without the promise of ever reaching a consensus. Regardless of one's position, the objective is to develop strategies to improve the practice of dermatology and the welfare of patients. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488372 Thu, 25 Jun 2009 07:32:21 +0100 2488372 http://www.medworm.com/index.php?rid=2488371&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000261%2Fabstract%3Frss%3Dyes Abstract: Malignant melanoma is a cutaneous malignancy characterized by high metastatic potential and an unpredictable course. Enormous amounts of research have been done into surgical and adjunctive therapies for melanoma. Given the regularity with which sentinel lymph node biopsy and completion lymph node dissection are performed at private and academic hospitals, it would seem that evidence supporting these procedures is not controversial. A growing body of studies, however, points to sentinel lymph node biopsy and completion lymph node dissection as ineffective treatment for malignant melanoma and necessitates a discussion of what constitutes standard of care. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488371 Thu, 25 Jun 2009 07:32:21 +0100 2488371 http://www.medworm.com/index.php?rid=2488370&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0900025X%2Fabstract%3Frss%3Dyes Abstract: In 2002, new guidelines for interactions with the pharmaceutical industry and physicians were published as an official code of conduct. Adherence to the guidelines was voluntary, and there were no provisions for discipline to companies who did not subscribe to the code or who subscribed but did not comply. Many of the code standards are routinely violated, sometimes egregiously, with many violations on easy display at national professional meetings. In response to further problems and complaints, tougher code standards—now famous for the specific ban on logo pens and coffee cups—were adopted in 2009. Subscription to the new code is voluntary, and there are no provisions for discipline or punishment for those companies who chose not to subscribe or who may violate its standard... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488370 Thu, 25 Jun 2009 07:32:21 +0100 2488370 http://www.medworm.com/index.php?rid=2488369&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000248%2Fabstract%3Frss%3Dyes Abstract: Acting as a speaker or consultant to the pharmaceutical industry, while adding to a physician's recognition and income, serves a vital role in graduate and postgraduate medical education. Such activities work, especially when one becomes involved with several different companies or organizations, can expose the speaker and researcher to a number of potential ethical conflicts. These include publication and prescribing bias. These also lead to the real or apparent conflict of interest when the consultant receives unearned, unjustified, or excessive compensation and gifts. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488369 Thu, 25 Jun 2009 07:32:21 +0100 2488369 http://www.medworm.com/index.php?rid=2488368&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000236%2Fabstract%3Frss%3Dyes Abstract: In 1729, Jonathan Swift wrote an essay with the “modest proposal” that one way to manage overpopulation among the poor would be for the rich to eat them. Although not as serious a problem as that faced by Swift's England, we have a problem with the effective impotence of our current methods used to disclose potential conflicts of interest in publications and presentations. If speakers or writers cannot be relied upon to describe honestly and accurately their conflicts, perhaps we may turn to their peers to do it for them. Although there are reasons this modest proposal may be as impractical as Swift's, at least it does not involve eating our lecturers. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488368 Thu, 25 Jun 2009 07:32:21 +0100 2488368 http://www.medworm.com/index.php?rid=2488367&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000224%2Fabstract%3Frss%3Dyes Abstract: The American Academy of Dermatology Ethics Committee has a key role in assessing members' adherence to the Code of Medical Ethics. It performs no disciplinary action on its own, referring validated complaints for judicial review. The most frequent complaints that the Ethics Committee has received in recent years have been cases involving expert witness testimony, complaints about American Academy of Dermatology members promoting products and services of questionable benefit for patients through false, misleading, and deceptive advertising and self-promotion, and reports of misuse of nonphysician clinicians. The steps by which a complaint is received and processed are detailed. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488367 Thu, 25 Jun 2009 07:32:21 +0100 2488367 http://www.medworm.com/index.php?rid=2488366&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000212%2Fabstract%3Frss%3Dyes The Accreditation Council for Graduate Medical Education (ACGME) defined six core competencies of what it took to make a good physician. Included in the competency “professionalism” is the demonstrated commitment to ethical principles. It is up to program directors of all specialties and subspecialties to develop ways to teach ethics as well as find ways to measure their success or lack thereof. Although many of us would find definitions difficult, we all feel that we know unethical behavior when we see it (although not always in ourselves). The problem with definitions is that ethics, morals, and appropriate professional behavior are not synonymous, although they often become muddled together. The decision to turn in a colleague for “unethical behavior” needs to be based on some s... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488366 Thu, 25 Jun 2009 07:32:21 +0100 2488366 http://www.medworm.com/index.php?rid=2488365&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000972%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488365 Thu, 25 Jun 2009 07:32:21 +0100 2488365 http://www.medworm.com/index.php?rid=2488364&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000947%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2488364 Thu, 25 Jun 2009 07:32:21 +0100 2488364 http://www.medworm.com/index.php?rid=2350258&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002228%2Fabstract%3Frss%3Dyes Jan Alkiewicz () was born on March 26, 1896, in Osieczna, in the Leszno district, the son of a medical practitioner. His secondary education imbued in him a passion for the ancient culture and an excellent command of Greek and Latin languages. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350258 Tue, 21 Apr 2009 07:54:46 +0100 2350258 http://www.medworm.com/index.php?rid=2350257&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08000461%2Fabstract%3Frss%3Dyes Why did I pursue a career in dermatology after earning my law degree…and why was I asked to write on this subject? I suppose, if you use Google as a metric, I am one of the dermatologists–who are also an attorney–who generates a tremendous number of hits (perhaps the second greatest following David Goldberg, MD, JD). I am also considered to be an expert in the area of law and dermatology; indeed, I write a column in Skin and Aging called Legalese. When I speak at national meetings, I am invited to speak about Law and Dermatology and not about psoriasis, acne, or the hedgehog gene. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350257 Tue, 21 Apr 2009 07:54:45 +0100 2350257 http://www.medworm.com/index.php?rid=2350256&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X0900042X%2Fabstract%3Frss%3Dyes Within the past several months, the dermatology community has been enriched by the publications of the autobiographies of two contemporary dermatologists. This is an area well known to “caretakers of the skin,” as there are at least 10 prior volumes recounting the lives of other prominent dermatologists. The books range from the memoirs of James Clarke White, the first professor of dermatology in the United States, to those of Marion B. Sulzberger, a distinguished leader of 20th century dermatology. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350256 Tue, 21 Apr 2009 07:54:44 +0100 2350256 http://www.medworm.com/index.php?rid=2350255&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002010%2Fabstract%3Frss%3Dyes Abstract: Buruli ulcer is an indolent necrotizing disease of the skin, subcutaneous tissue, and bone that is caused by Mycobacterium ulcerans. Buruli ulcer is presently the third most common mycobacterial disease of humans, after tuberculosis and leprosy, and the least understood of the three. The disease remained largely ignored by many national public health programs, but more recently, it has been recognized as an emerging health problem, primarily due to its frequent disabling and stigmatizing complications. The contribution discusses various aspects of Buruli ulcer, including its geographic distribution, incidence, and prevalence; mode of transmission, pathogenesis, and immunity; clinical manifestations; laboratory diagnosis; differential clinical diagnosis; and treatment. (Source: Cl... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350255 Tue, 21 Apr 2009 07:54:41 +0100 2350255 http://www.medworm.com/index.php?rid=2350254&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002204%2Fabstract%3Frss%3Dyes Abstract: Bed bugs, leeches, and hookworm-related cutaneous larva migrans are skin infestations that are usually considered of minor importance because they produce discomfort rather than cause or transmit disease. Bed bugs have been increasing tremendously in high-income countries in recent years, causing distress to affected individuals and economic loss. Infestation by land leeches causes mainly unpleasant skin reactions, whereas infestation by aquatic leeches may be more dangerous, leading to anemia and in severe cases, to death. Cutaneous larva migrans produces an intense pruritus that can be exasperating for the patient and cause sleep disturbance. An overview is given of these three infestations with a discussion of the causative agents, transmission, clinical manifestations, diagno... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350254 Tue, 21 Apr 2009 07:54:36 +0100 2350254 http://www.medworm.com/index.php?rid=2350253&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002198%2Fabstract%3Frss%3Dyes Abstract: Infective dermatitis represents a severe form of recurrent eczematous skin change that presents in childhood. It was first described in 1966. Later, the association of infective dermatitis with an underlying human T-cell lymphotropic virus infection was recognized. Chronic infective dermatitis is associated with an increased risk of malignant transformation and may be an early sign of underlying leukemia or T-cell lymphoma, or both. Infective dermatitis is endemic in parts of South America (Peru, Colombia, Brazil), parts of Africa, the Caribbean, and southwestern Japan. Treatment is difficult, and not infrequently cases, are refractory to therapy. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350253 Tue, 21 Apr 2009 07:54:28 +0100 2350253 http://www.medworm.com/index.php?rid=2350252&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002186%2Fabstract%3Frss%3Dyes Abstract: Bartonella spp are fastidious bacteria that occur in the blood of man and mammals; they are usually vector borne but can also be transmitted by animal scratches and bites. The bartonelloses of medical importance comprise Carrión's disease, trench fever, cat-scratch disease, bacillary angiomatosis, and peliosis hepatis. Carrión's disease, known as Oroya fever in the acute phase and verruga peruana (Peruvian wart) in its chronic form, has curious manifestations that, until recently, have been restricted in their geographic distribution to dwellers of the high, dry Andean valleys, but new sites of disease are emerging. Trench fever is associated with louse-borne disease and homelessness. Cat-scratch disease, bacillary angiomatosis, and peliosis hepatis are increasingly being recog... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350252 Tue, 21 Apr 2009 07:54:15 +0100 2350252 http://www.medworm.com/index.php?rid=2350251&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002174%2Fabstract%3Frss%3Dyes Abstract: Rural dermatology in the tropics is determined by socioeconomic factors, climate, and skin type. Lack of interest of the profession leads to late and inadequate diagnosis and treatment. No proper data on the magnitude of the problem are available, even though a great number of the world population live under those conditions. This contribution provides an overview of the most common skin diseases, in particular, infections and infestations. Other skin conditions, both eczematous and immune-mediated, that are typical for the rural tropics also are discussed. Etiology, pathology, and treatments are presented against the socioeconomic background. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350251 Tue, 21 Apr 2009 07:54:07 +0100 2350251 http://www.medworm.com/index.php?rid=2350250&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002162%2Fabstract%3Frss%3Dyes Abstract: Although geography is the main determinant of tropical dermatology, some definitions include the infections carried by the predators living there and many will include any skin condition occurring between the tropics of Cancer and Capricorn, even if they are even more common elsewhere. A description of the history of tropical dermatology is dependent on travelers who provided reports. Its literature is often provided by military men. Dermatology also may be described in a manner that leaves out much of what happens to the skin, such as wounds and burns or manifestations of infections and malnutrition. Important too is the perspective of treatment that may include more than one system of medicine. There is also the overlap with the cosmetic. This essay draws attention to the write... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350250 Tue, 21 Apr 2009 07:53:57 +0100 2350250 http://www.medworm.com/index.php?rid=2350249&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X08002150%2Fabstract%3Frss%3Dyes The good provenance of a wine, so it is said, is a good guide to its distinction, and certainly this notion rings true with the selection of esteemed authors that have contributed to this, the third part of our studies in tropical dermatology. Part I appeared as the May/June 2006 issue, and part II was published as the March/April 2007 issue. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350249 Tue, 21 Apr 2009 07:53:51 +0100 2350249 http://www.medworm.com/index.php?rid=2350248&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000686%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350248 Tue, 21 Apr 2009 07:53:51 +0100 2350248 http://www.medworm.com/index.php?rid=2350247&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09000650%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2350247 Tue, 21 Apr 2009 07:53:48 +0100 2350247 http://www.medworm.com/index.php?rid=2137767&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19167995%26dopt%3DAbstract Authors: Morganti P PMID: 19167995 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137767 Wed, 28 Jan 2009 08:29:13 +0100 2137767 http://www.medworm.com/index.php?rid=2137766&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19167996%26dopt%3DAbstract Authors: Dweck AC The term "cosmeceutical" is not defined in terms of the law. A review of some of the more commonly used dietary supplements and their chemistry and topical use confirms that there is merit in using these plants both internally and externally. The role of flavonoids, isoflavones, phytosterol, and plant hormone-related chemicals are examined for their physiological effect. PMID: 19167996 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137766 Wed, 28 Jan 2009 08:29:09 +0100 2137766 http://www.medworm.com/index.php?rid=2137765&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19167997%26dopt%3DAbstract Authors: Viola P, Viola M Fats are indispensable to life not only as an energy source but also for their structural role in the skin, retina, nervous system, lipoproteins, and biologic membranes. They are also precursors of important hormones and constitute the vehicle for the absorption of liposoluble vitamins. Nutritionists recommend a balanced lipid intake corresponding to a total amount of fats equal to 25% to 30% of total calories with a ratio in monounsaturated and polyunsaturated fatty acids. Thus, olive oil, with its balanced fatty acid composition, is of high nutritional value. Moreover, extra virgin olive oil, extracted from a fruit, has an important value related to the antioxidant power of minor components. Extra virgin olive oil contains 98% to 99% triglycerides and 1% to ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137765 Wed, 28 Jan 2009 08:29:03 +0100 2137765 http://www.medworm.com/index.php?rid=2137764&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19167998%26dopt%3DAbstract Authors: Morganti P Nutrition plays an important role in the treatment of many diseases, and the right choice of nutrients can help to prevent disorders and improve the quality of life. Epidemiologic studies suggest that there is a close relationship between ultraviolet exposure (high level of reactive oxygen species) and the intake of specific dietary factors (eg antioxidants), and the diminished risk of developing cancer, coronary heart disease, or cataracts. Free radicals and reactive oxygen species are synthesized endogenously (eg, in energy metabolism and the antimicrobial defense system of the body) or produced as reactions to exogenous exposure (eg, cigarette smoke, imbalanced diet, exhaustive exercise, environmental pollutants, and food contaminants). Human dietary intervention... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137764 Wed, 28 Jan 2009 08:29:00 +0100 2137764 http://www.medworm.com/index.php?rid=2137763&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19167999%26dopt%3DAbstract This study considers the different pathways that generate oxidative stress, which is a physiologic process that can become dangerous if becomes excessive and overcomes the reserve of antioxidants. Some of the most important methods to determine oxidative stress in plasma, both in humans and in experimental animals, are discussed; particular attention is given to the d-ROMs test, which detects the hydroperoxides in plasma and is a very simple and reliable method. The antioxidant hierarchy also is discussed to indicate the most powerful physiological antioxidant and those derived from food intake or supplementation. As every antioxidant also can be a pro-oxidant, indications are given about their use and how to avoid the administration of high dosages of a single antioxidant. PMID: 19167... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137763 Wed, 28 Jan 2009 08:28:56 +0100 2137763 http://www.medworm.com/index.php?rid=2137762&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168000%26dopt%3DAbstract This article reviews the scientific literature pertaining to the effects that lutein and zeaxanthin exhibit in the human eye and skin. PMID: 19168000 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137762 Wed, 28 Jan 2009 08:28:53 +0100 2137762 http://www.medworm.com/index.php?rid=2137761&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168001%26dopt%3DAbstract Authors: Berra B, Rizzo AM For many years, melatonin has been known to interact with circadian rhythms. New evidence indicates that melatonin acts as a free radical scavenger and antioxidant. Moreover, melatonin prevents apoptosis in different types of cells, because it induces mRNA levels of several antioxidant enzymes. It is evident that melatonin is involved in the cellular bioenergetic system as a mechanism that counteracts the progression of Alzheimer's disease. PMID: 19168001 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137761 Wed, 28 Jan 2009 08:28:49 +0100 2137761 http://www.medworm.com/index.php?rid=2137760&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168002%26dopt%3DAbstract Authors: Gruenwald J Natural substances are generally preferred over chemical ones and are generally seen as healthy. The increasing demand for natural ingredients, improving health and appearance, is also attracting beverages as the fastest growing segment on the functional food market. Functional beverages are launched as fortified water, tea, diary or juices claiming overall nutrition, energy, anti-aging or relaxing effects. The substitution of so called superfruits, such as berries, grapes, or pomegranate delivers an effective range of beneficial compounds, including vitamins, fatty acids, minerals, and anti-oxidants. In this context, new exotic and African fruits could be useful sources in the near future. Teas and green botanicals, such as algae or aloe vera are also rich in effe... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137760 Wed, 28 Jan 2009 08:28:45 +0100 2137760 http://www.medworm.com/index.php?rid=2137759&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168003%26dopt%3DAbstract Authors: Wagner AE, Rimbach G Ascorbigen (ABG) belongs to the glucosinolate family and occurs mainly in Brassica vegetables. It is formed by its precursor glucobrassicin. Glucobrassicin is enzymatically hydrolyzed to indole-3-carbinol, which in turn reacts with L-ascorbic acid to ABG. The degradation of glucobrassicin is induced by plant tissue disruption. The ABG formation depends on pH and temperature. The degradation of ABG in acidic medium causes a release of l-ascorbic acid and a formation of methylideneindolenine; in more alkaline medium, the degradation of ABG causes the formation of 1-deoxy-1-(3-indolyl)-alpha-L-sorbopyranose and 1-deoxy-1-(3-indolyl)-alpha-l-tagatopyranose. ABG may partly mediate the known anticarcinogenic effect of diets rich in Brassicacae. Furthermore, ABG ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137759 Wed, 28 Jan 2009 08:28:42 +0100 2137759 http://www.medworm.com/index.php?rid=2137758&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168004%26dopt%3DAbstract Authors: Serafini M, Testa MF Plant-based foods (such as fruit and vegetables, wine, nuts, natural vegetable oils, and whole grains) are an important component of traditional diets in Mediterranean regions. A large, consistent body of scientific evidence demonstrates that diets rich in plant foods provide protection against degenerative diseases; however, despite the consensus of the evidence about the health effect of plant foods, it is unclear which components of plant-based foods are protective and what their mechanism of action is. One of the hypotheses postulated to explain the protective effect of plant food, the antioxidant hypothesis, is based on their high content of bioactive molecules. Recent evidence suggests that it is the variegate composition of the plant food, an optima... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137758 Wed, 28 Jan 2009 08:28:37 +0100 2137758 http://www.medworm.com/index.php?rid=2137757&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168005%26dopt%3DAbstract Authors: Berra B, Rizzo AM The glycemic index (GI) is a ranking system for carbohydrates' effect on blood glucose levels. It compares available carbohydrates gram for gram in individual foods, providing a numerical, evidence-based index of postprandial glycemia. The glycemic load (GL) is a ranking system for carbohydrate content in food portions based on their GI and the portion size. These two markers increasingly are being used to prevent typical diseases of the Western world, including type 2 diabetes mellitus, cardiovascular disease, obesity, metabolic syndrome, and acne. Data on the efficacy of GI and GL in the treatment of Western population diseases are discussed and critically evaluated, with a particular focus on acne and other skin disorders. PMID: 19168005 [PubMed - in p... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137757 Wed, 28 Jan 2009 08:28:34 +0100 2137757 http://www.medworm.com/index.php?rid=2137756&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168006%26dopt%3DAbstract Authors: Faber WR, Bos JD, Hulsebosch HJ PMID: 19168006 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137756 Wed, 28 Jan 2009 08:28:30 +0100 2137756 http://www.medworm.com/index.php?rid=2137755&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19168007%26dopt%3DAbstract Authors: Benitez YD PMID: 19168007 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2137755 Wed, 28 Jan 2009 08:28:27 +0100 2137755 http://www.medworm.com/index.php?rid=2056196&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095148%26dopt%3DAbstract Authors: Grant-Kels JM PMID: 19095148 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056196 Mon, 22 Dec 2008 09:04:33 +0100 2056196 http://www.medworm.com/index.php?rid=2056195&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095149%26dopt%3DAbstract Authors: Garbe C, Leiter U Rising incidence rates of cutaneous melanoma have been observed during the last four decades in white populations worldwide. The cancer statistics in the United States have revealed 6 cases per 100,000 and year at the beginning of the 1970s and 18 cases per 100,000 inhabitants and year at the beginning of 2000, demonstrating a threefold increase in incidence rates. Incidence rates in central Europe increased in the same time period from 3 to 4 cases to 10 to 15 cases per 100,000 inhabitants and year, which is very similar to the increase in the United States. Cohort studies from several countries indicate that the trend of increasing incidence rates will continue in the future for at least the next 2 decades; thus, an additional doubling of incidence rates is... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056195 Mon, 22 Dec 2008 09:04:14 +0100 2056195 http://www.medworm.com/index.php?rid=2056194&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095150%26dopt%3DAbstract Authors: Stratigos AJ, Katsambas AD The incidence of cutaneous melanoma has increased substantially in most white populations during the past several decades. Despite improvements in the early recognition of melanoma and the use of novel diagnostic techniques that enhance our diagnostic capabilities, disease-related mortality remains a significant public health issue. In the absence of effective treatment approaches for advanced disease, the best means for reducing deaths by melanoma are screening as well as professional and public education. The role of population-or community-based screening remains controversial, but evidence from self-selected screening campaigns, health care professional surveillance, and specialized pigmented lesions clinics underscores the value of screening and... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056194 Mon, 22 Dec 2008 09:03:48 +0100 2056194 http://www.medworm.com/index.php?rid=2056193&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095151%26dopt%3DAbstract Authors: Braun RP, Oliviero M, Kolm I, French LE, Marghoob AA, Rabinovitz H Dermoscopy has been described as a useful tool for the early diagnosis of melanoma and the differential diagnosis of pigmented lesions of the skin. This has been proven by three independent meta analyses of the literature. Dermoscopy is a fast evolving field with a high number of new publications every year. Initially, the use of dermoscopy was limited to pigmented lesions, but it is used more and more in other situations. It has become an important tool for the diagnosis of nail pigmentations, hair and scalp disorders, and so forth. In this article we try to provide an update on recent trends and developments in dermoscopy. PMID: 19095151 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056193 Mon, 22 Dec 2008 09:03:36 +0100 2056193 http://www.medworm.com/index.php?rid=2056192&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095152%26dopt%3DAbstract Authors: Psaty EL, Halpern AC Relative to other specialties, dermatologists have been slow to adopt advanced technologic diagnostic aids. Most skin disease can be diagnosed by simple visual inspection, and the skin is readily accessible for a diagnostic biopsy. Diagnostic aids, such as total body photography and dermoscopy, improve the clinician's ability to diagnose melanoma beyond unaided visual inspection, however, and are now considered mainstream methods for early detection. Emerging technologies such as in vivo reflectance confocal microscopy are currently being investigated to determine their utility for noninvasive diagnosis of melanoma. This review summarizes the currently available cutaneous imaging devices and new frontiers in noninvasive diagnosis of skin disease. We antici... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056192 Mon, 22 Dec 2008 09:03:22 +0100 2056192 http://www.medworm.com/index.php?rid=2056191&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095153%26dopt%3DAbstract Authors: Nelson AA, Tsao H PMID: 19095153 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056191 Mon, 22 Dec 2008 09:03:18 +0100 2056191 http://www.medworm.com/index.php?rid=2056190&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095154%26dopt%3DAbstract Authors: Payette MJ, Katz M, Grant-Kels JM Significant prognostic information is available in a routine melanoma dermatopathology report. Features that are enumerated in the pathology report and that portend a potentially poorer prognosis are older age, site (acral, head, neck), male sex, increasing Breslow tumor thickness, increasing Clark's level, ulceration, increasing number of mitoses, vertical growth phase, regression, absence of a host inflammatory response, increased tumor vascularity, angiotropism, vascular invasion, neurotropism, marked atypia, and satellite metastasis. PMID: 19095154 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056190 Mon, 22 Dec 2008 09:03:14 +0100 2056190 http://www.medworm.com/index.php?rid=2056189&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095155%26dopt%3DAbstract Authors: Carlson JA, Ross JS, Slominski AJ Routine light microscopy supplemented with immunohistochemistry in cases of metastatic or spindle cell melanoma are standards of care for the diagnosis and staging of melanoma. Not all melanocytic tumors can be confidently classified as melanoma or benign nevus by histology, however. In addition, tumor thickness and ulceration, the current American Joint Classification on Cancer prognosticators for primary cutaneous (stages I and II) melanoma used in clinical practice, do not perfectly predict an individual's clinical course. Recent advances in molecular techniques and bioinformatics mandate testing and use of novel methods for the detection, diagnosis, and classification of melanocytic tumors that can accurately predict tumor behavior and hel... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056189 Mon, 22 Dec 2008 09:03:10 +0100 2056189 http://www.medworm.com/index.php?rid=2056188&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095156%26dopt%3DAbstract Authors: Friedman RJ, Farber MJ, Warycha MA, Papathasis N, Miller MK, Heilman ER Dysplastic nevi have become an increasing focus clinically, with evidence that they are associated with a higher risk of developing melanoma. However, there still is contention regarding the significance of dysplastic nevi. This contribution provides an overview of the history, epidemiology, genetics, clinical and histologic features, and procedures for clinical management of dysplastic nevi. Since dysplastic nevi were described originally in 1978, a great deal of research has examined the epidemiology of these lesions and the genetic factors related to the development of dysplastic nevi. However, there is disagreement regarding the clinical management of dysplastic nevi and the histologic definition of dy... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056188 Mon, 22 Dec 2008 09:03:04 +0100 2056188 http://www.medworm.com/index.php?rid=2056187&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095157%26dopt%3DAbstract Authors: Driscoll MS, Grant-Kels JM Multiple difficult questions arise when a pregnant woman presents to the dermatologist with a changing melanocytic nevus or melanoma. Our review of the literature provides some insight into these issues. We recommend that a changing pigmented lesion in the pregnant woman should be biopsied promptly and can be safely performed. Women who have dysplastic nevus syndrome require closer monitoring during pregnancy. For the pregnant woman with a confirmed, localized melanoma, prognosis does not appear to be affected by pregnancy. Likewise, limited data indicate that pregnancy before or after a diagnosis of melanoma does not affect prognosis. Wide local excision may be performed safely, but if sentinel lymph node mapping and biopsy is indicated, the techniq... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056187 Mon, 22 Dec 2008 09:02:59 +0100 2056187 http://www.medworm.com/index.php?rid=2056186&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095158%26dopt%3DAbstract Authors: Shields CL, Shields JA Primary ocular melanoma can involve the uveal tract, conjunctiva, eyelid, or orbit. Uveal melanoma is the most common ocular melanoma and carries a serious prognosis, especially if the tumor is medium or large in size. Conjunctival melanoma manifests on the surface of the eye and has been increasing in incidence. Eyelid and primary orbital melanoma are the least common variants. Early diagnosis from annual ocular examination by an experienced ophthalmologist and treatment strategies are reviewed. PMID: 19095158 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056186 Mon, 22 Dec 2008 09:02:55 +0100 2056186 http://www.medworm.com/index.php?rid=2056185&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095159%26dopt%3DAbstract Authors: Fellner MJ, Majeed MH Delusions of parasitosis are usually a monosymptomatic dermatopsychiatric disorder manifested by the fixed false belief that insects are crawling over the body producing an intractable itch. Also known as parasitophobia, this disease can also be associated with other psychiatric disorders, such as schizophrenia or obsessive compulsive disorders. In most cases, the delusion is encapsulated and other mental functions remain intact. Parasitophobia is usually seen in middle-aged women and has proven a vexing problem for dermatologists to treat because patients are often reluctant to obtain a psychiatric consultation and wary of taking antipsychotic or antidepressant medication. Four patients with this disorder illustrate the problem, provide a new approach to... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056185 Mon, 22 Dec 2008 09:02:50 +0100 2056185 http://www.medworm.com/index.php?rid=2056184&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19095160%26dopt%3DAbstract Authors: Stavrianeas NG, Toumbis Ioannou E PMID: 19095160 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=2056184 Mon, 22 Dec 2008 09:02:43 +0100 2056184 http://www.medworm.com/index.php?rid=1901757&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940538%26dopt%3DAbstract Authors: Serri R PMID: 18940538 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901757 Fri, 24 Oct 2008 12:35:53 +0100 1901757 http://www.medworm.com/index.php?rid=1901756&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940539%26dopt%3DAbstract Authors: Rinaldi F Lasers and light-based treatments are extremely useful and now standardized techniques in the management of different stages of photoaging. To obtain the most successful results, protocols involving single or combination systems can be used, depending on skin photodamage. In the last years, the trend is to choose noninvasive or minimally invasive treatments, with the aim of reducing the risk of side effects, complications, and downtime. Selective photothermolysis obtained with lasers and with intense pulse light, which is presently considered the most suitable technique by a growing number of authors, is an extremely valid procedure, in particular in types I and II, according to the Glogau classification. Photodynamic therapy is another effective tool in photoaging t... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901756 Fri, 24 Oct 2008 12:35:50 +0100 1901756 http://www.medworm.com/index.php?rid=1901755&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940540%26dopt%3DAbstract Authors: Sukal SA, Geronemus RG Thermage is a noninvasive nonablative device that uses monopolar radiofrequency energy to bulk heat underlying skin while protecting the epidermis to produce skin tightening. It is used for the treatment of rhytids on the face including the periorbital region and lower face, and more recently, for off-face applications. Studies have shown that it can impart mild tightening of periorbital mid, and lower facial laxity. Other radiofrequency devices have also shown objective improvements in cellulite of the buttocks and thigh regions. Thermage is an efficacious and safe nonsurgical alternative for treating mild skin laxity. PMID: 18940540 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901755 Fri, 24 Oct 2008 12:35:47 +0100 1901755 http://www.medworm.com/index.php?rid=1901754&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940541%26dopt%3DAbstract This article will provide readers with an extensive review of the popular chosen topical photosensitizers, varied used light sources and lasers, and medical and cosmetic indications treated with photodynamic therapy. PMID: 18940541 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901754 Fri, 24 Oct 2008 12:35:44 +0100 1901754 http://www.medworm.com/index.php?rid=1901753&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940542%26dopt%3DAbstract Authors: González S, Fernández-Lorente M, Gilaberte-Calzada Y UV radiation is the main etiological agent of most types of skin cancer and a key factor responsible for photoaging. Photoprotection is thus critical to avoid these undesired effects. Sunscreens rank among the best photoprotective measures. Sunscreens are the main components of lotions and creams used to prevent UV-induced damage or to ameliorate its harmful effects. There are 3 types of sunscreens: physical photon blockers, antioxidants, and stimulators of repairing mechanisms. This review summarizes current topics in the development of sunscreens, with special emphasis on substances of natural origin bearing photoscreening, antioxidant, or repairing properties. The characterization of different parameters to eval... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901753 Fri, 24 Oct 2008 12:35:42 +0100 1901753 http://www.medworm.com/index.php?rid=1901752&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940543%26dopt%3DAbstract Authors: Draelos ZD The cosmeceutical realm is composed of functional cosmetics designed to adorn face and body without changing the structure of the human form. Although this may seems confusing, indeed cosmeceuticals have never been well defined. Cosmeceuticals developed for facial application typically claim to induce more even skin tone, improve skin texture, increase skin radiance, decrease the appearance of skin wrinkling, and provide antiaging benefits. Nondrug active ingredients are usually incorporated into moisturizing vehicles designed to accomplish the aforementioned claims. There is no doubt that cosmeceuticals represent the most rapidly expanding frontier in dermatology. PMID: 18940543 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901752 Fri, 24 Oct 2008 12:35:39 +0100 1901752 http://www.medworm.com/index.php?rid=1901751&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940544%26dopt%3DAbstract Authors: Serri R, Iorizzo M Evidence from a randomized clinical trial showed that, in spite of the many surgical procedures effective in ameliorating the clinical appearance of photoaged skin, the only medical therapy with proven benefits in photoaged skin are topical retinoids, in particular tretinoin, isotretinoin, and tazarotene. The application of retinoids might not only clinically and biochemically repair photoaged skin, but their use might also prevent photoaging. Furthermore, new evidence suggests a beneficial role of topical retinoids in the treatment of intrinsically aged skin. PMID: 18940544 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901751 Fri, 24 Oct 2008 12:35:36 +0100 1901751 http://www.medworm.com/index.php?rid=1901750&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940545%26dopt%3DAbstract Authors: Dioguardi FS The skin is an important organ, and the need for attention to its metabolic requirements is often underestimated by professionals involved with its integrity and beauty. Amino acids are the indispensable nutritional basis for the maintenance of its integrity. The skin has very peculiar amino acid needs, which should be acknowledged and supplied if necessary. PMID: 18940545 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901750 Fri, 24 Oct 2008 12:35:32 +0100 1901750 http://www.medworm.com/index.php?rid=1901749&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940546%26dopt%3DAbstract Authors: Rona C, Berardesca E The frenzied rhythm of our times leads our patients not only to resource to diet integrators-remorselessly overcoming difficulties or prejudices-to fulfill increasingly frequent nutritional needs due to decreasingly "correct" eating habits, but also to fight against a myriad of skin conditions. The rationale of a combined approach for the antiaging treatment of skin is based on the synergic effect between functional substances applied locally, where the problem arises, and other agents working from the inside to correct a need, to restore altered functions or conditions and to guarantee the correct intake of nutrients or active substances. This work discusses the active ingredients mostly used in the oral treatment of skin aging, together with the scientif... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901749 Fri, 24 Oct 2008 12:35:29 +0100 1901749 http://www.medworm.com/index.php?rid=1901748&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940547%26dopt%3DAbstract This article considers and assesses all technical and practical advice to make women look younger. The different sections aim to deepen personal research and to supply a valid basis for improvement of one's own figure. This article, with my experience and competence, recommends the best choices for each area, from makeup to hairdos, clothes, and accessories. The sections will help the reader identify the salient points-the ones you should pay more attention to and the ones you should avoid so as not to obtain the opposite of what you wanted or a counterproductive effect. Finally, the final part highlights the best colors and fabrics to add light to the face. The entire article is filled with useful strategies and tips to add that extra touch that each reader can personalize to create a uni... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901748 Fri, 24 Oct 2008 12:35:26 +0100 1901748 http://www.medworm.com/index.php?rid=1901747&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940548%26dopt%3DAbstract Authors: Okun MM PMID: 18940548 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901747 Fri, 24 Oct 2008 12:35:23 +0100 1901747 http://www.medworm.com/index.php?rid=1901746&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940549%26dopt%3DAbstract Authors: Martinelli PT, Czelusta A, Peterson SR PMID: 18940549 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901746 Fri, 24 Oct 2008 12:35:20 +0100 1901746 http://www.medworm.com/index.php?rid=1901745&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940550%26dopt%3DAbstract Authors: Cohen PR PMID: 18940550 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901745 Fri, 24 Oct 2008 12:35:17 +0100 1901745 http://www.medworm.com/index.php?rid=1901744&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18940551%26dopt%3DAbstract Authors: Parish LC, Ramos-E-Silva M, Parish JL PMID: 18940551 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1901744 Fri, 24 Oct 2008 12:35:14 +0100 1901744 http://www.medworm.com/index.php?rid=1746527&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755358%26dopt%3DAbstract Authors: Schön MP PMID: 18755358 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746527 Sun, 31 Aug 2008 10:59:13 +0100 1746527 http://www.medworm.com/index.php?rid=1746526&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755359%26dopt%3DAbstract Authors: van de Kerkhof PC The expression of psoriasis is highly variable and may even differ within a single patient. This comprises not only extent of lesions, severity in terms of erythema induration, and scaling or visibility of the lesions, but particularly the responsiveness to antipsoriatic treatments in the past. Therefore, the management of psoriasis has to reconcile the variability of treatment responses, which, to some extent, may be genetically determined but also are the result of nongenetic factors, including triggering factors and adaptation (habituation) to treatments. In this article, we will provide a patient-based approach on the management of psoriasis, which reconciles the heterogeneity of psoriasis in individual patients. PMID: 18755359 [PubMed - in process] (... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746526 Sun, 31 Aug 2008 10:59:09 +0100 1746526 http://www.medworm.com/index.php?rid=1746525&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755360%26dopt%3DAbstract Authors: Radtke MA, Augustin M With a prevalence of 2% to 3%, psoriasis is a very common chronic disease worldwide and generates therapy costs and continuing cost for health insurance and patients and their families. Cost-political changes in health care and the ever increasing health-economic demands in all areas of the health system make it necessary to differentiate between the two when recording the expenses for a disease. The main characteristics of the pharmacoeconomic evaluation are the record of costs, the cost-benefit and cost-effectiveness ratio, and efficiency of various treatment forms. Numerous publications discuss the cost of individual forms of therapy in the treatment of psoriasis, but there are fewer studies on the total cost of psoriasis therapy, especially studies th... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746525 Sun, 31 Aug 2008 10:59:06 +0100 1746525 http://www.medworm.com/index.php?rid=1746524&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755361%26dopt%3DAbstract Authors: Bos JD, Spuls PI Topical therapy in psoriasis is of use in mild cases. It is also applied as an adjunct to phototherapy and systemic treatments in moderate to severe cases. Long-established pharmaceuticals such as cignolin, tar preparations, and glucocorticoids are still in use. Newer topical agents such as vitamin A and D derivatives are gradually replacing them. Combining a vitamin D derivative and a strong glucocorticoid now seems to be the most efficient way to treat psoriasis when topical agents are indicated. There is a growing list of "alternative" treatment options, where evidence is generally absent. Rewarding investments should perhaps be directed at intervening with molecules of innate immunity. Superfluous activation of natural immune system cascades is now in view... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746524 Sun, 31 Aug 2008 10:59:03 +0100 1746524 http://www.medworm.com/index.php?rid=1746523&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755362%26dopt%3DAbstract Authors: Warren RB, Griffiths CE Despite the current use and ongoing development of the biological therapies 'traditional' systemic agents will continue to form a key part of the therapeutic armamentarium for patients with severe psoriasis. Long-term maintenance therapy with retinoids and methotrexate is cost-effective and, for many patients with psoriasis, life changing. Regular monitoring is required for both treatments, particularly methotrexate to prevent significant bone marrow suppression and hepatotoxicity. Ideally, cyclosporine should be used for short courses of 3 to 4 months duration, within which it provides excellent disease control. Close assessment of renal function and blood pressure is essential. PMID: 18755362 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746523 Sun, 31 Aug 2008 10:58:59 +0100 1746523 http://www.medworm.com/index.php?rid=1746522&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755363%26dopt%3DAbstract Authors: Wozel G Psoriasis comprises a broad spectrum of different clinical courses among which the chronic stable psoriasis by far occurs most frequently. The clinical presentation ranges from mild disease to more serious forms involving large areas of skin and/or joint disease. A number of modifying factors may impact on treatment choice in individual cases (eg, location of the lesions, disease phase, treatment history, response to previous treatments, comorbidity). Aside from this consideration, there are special localizations that remain some of the most difficult regions to control. Such entities are the scalp, nails, and intertriginous areas. Topical treatment of such different-to-treat areas has to be considered as a first-line intervention strategy, at least in those patients w... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746522 Sun, 31 Aug 2008 10:58:57 +0100 1746522 http://www.medworm.com/index.php?rid=1746521&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755364%26dopt%3DAbstract This article reviews the current therapeutic principles for PsA. PMID: 18755364 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746521 Sun, 31 Aug 2008 10:58:53 +0100 1746521 http://www.medworm.com/index.php?rid=1746520&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755365%26dopt%3DAbstract Authors: Schneider LA, Hinrichs R, Scharffetter-Kochanek K Phototherapy, whose first application for psoriasis dates back to almost a century now, is still an actual mainstay of treatment. We discuss in detail the radiophysical aspects involved in the therapy, the different treatment modalities, and all aspects related to clinical application of phototherapy. By looking at new insights on the molecular mode of action, it becomes evident that phototherapy is in fact the oldest "biological" therapeutic strategy, whose target is directly the T-cell-mediated immunopathology of psoriasis. In an outlook, we discuss finally the current cost effectiveness calculations, important issues in times of increasingly tight public health budgets. In summary, this review points out that phototherapy is... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746520 Sun, 31 Aug 2008 10:58:51 +0100 1746520 http://www.medworm.com/index.php?rid=1746519&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755366%26dopt%3DAbstract Authors: Kazandjieva J, Grozdev I, Darlenski R, Tsankov N In the era when biological treatments for psoriasis are gaining more and more popularity, climatotherapy represents a safe and efficient alternative to the conventional therapeutic modalities. Climatotherapy comprises alternative treatment methods, which are based on the healing capacities of natural resources. This paper provides the reader with relevant information on the different climatotherapeutic methods, the intimate mechanisms of their action, and the cumulated clinical experience in the treatment of psoriasis. The positive effect of thalassotherapy for psoriasis has been known since ancient times. However, in the past decades a number of controlled studies revealed the efficacy of thalassotherpay in the treatment of pso... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746519 Sun, 31 Aug 2008 10:58:48 +0100 1746519 http://www.medworm.com/index.php?rid=1746518&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755367%26dopt%3DAbstract This article summarizes the important aspects of efficacy, safety, and practicability of TNF antagonists in the treatment of psoriasis. This article may be helpful for the daily routine when selecting the right therapy for a patient and managing the TNF antagonist during maintenance therapy. PMID: 18755367 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746518 Sun, 31 Aug 2008 10:58:45 +0100 1746518 http://www.medworm.com/index.php?rid=1746517&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755368%26dopt%3DAbstract Authors: Sugiyama H, McCormick TS, Cooper KD, Korman NJ Alefacept is the first biologic agent approved by the US Food and Drug Administration for the treatment of psoriasis. To date, more than 1000 patients with moderate to severe psoriasis have been enrolled in phase III clinical trials of alefacept. More than 30% of patients treated with 2 courses of alefacept reached a Physician's Global Assessment of clear to almost clear, and approximately 40% and 70% of patients achieved a Psoriasis Area Severity Index score of 75 and 50 after the same regimen. Alefacept is well tolerated, and there have been no reports of significant systemic toxicity or serious treatment-related adverse events. PMID: 18755368 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746517 Sun, 31 Aug 2008 10:58:43 +0100 1746517 http://www.medworm.com/index.php?rid=1746516&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755369%26dopt%3DAbstract Authors: Schön MP Efalizumab is a humanized monoclonal antibody directed against the CD11a subunit of the lymphocyte function-associated antigen 1. It has been approved for the treatment of moderate-to-severe plaque psoriasis. Efalizumab has been shown in several clinical trials to be effective and well tolerated in the treatment of patients with moderate-to-severe psoriasis. The safety profile of continuous therapy with efalizumab-as far as it is currently available-is favorable. Mode of action, pharmacological profile, clinical indications and efficacy, safety, and tolerability as well as practical considerations of efalizumab are reviewed in this article. PMID: 18755369 [PubMed - as supplied by publisher] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746516 Sun, 31 Aug 2008 10:58:39 +0100 1746516 http://www.medworm.com/index.php?rid=1746515&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755370%26dopt%3DAbstract Authors: Papp KA Monitoring patients on therapy consists of 2 parts: evaluation of response and mitigation of risk. Biologics for the treatment of psoriasis are no different. Although laboratory assessments are sometimes necessary, the key elements to appropriate monitoring are clinical assessments and vigilant reinforcement of signs and symptoms, which may portend undesirable adverse effects to the patient. Identifying expected response to therapy establishes one objective of monitoring. There is no precise threshold for response, but given the array of therapies and the relatively high response rates, a 75% improvement in clinical disease state is reasonable. Less well established is a reasonable time over which the expected improvement should occur. For alefacept, there are no data ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746515 Sun, 31 Aug 2008 10:58:36 +0100 1746515 http://www.medworm.com/index.php?rid=1746514&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755371%26dopt%3DAbstract Authors: Yazdi MR, Mrowietz U Several clinical studies have shown that systemic therapy with fumaric acid esters (FAEs) in patients with moderate to severe psoriasis is effective and has a good long-term safety profile. For therapeutic use, tablets with a defined mixture of FAEs (dimethylfumarate [DMF] and three different salts of monoethylfumarate) are registered in Germany. There is evidence that DMF is the most essential component in this formulation with an antipsoriatic effect. Currently, there are few data on the pharmacokinetics of fumarates in human beings. DMF seems to act as a prodrug for its main metabolite: monomethylfumarate. This hypothesis was supported by the observation that only monomethylfumarate was detected in the plasma of human beings after the oral administratio... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746514 Sun, 31 Aug 2008 10:58:34 +0100 1746514 http://www.medworm.com/index.php?rid=1746513&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755372%26dopt%3DAbstract Authors: Li YY, Zollner TM, Schön MP Tissue-selective recruitment of immunocytes to cutaneous tissues, a complex multistep cascade mediated by a large variety of cytokines, chemokines, and adhesion molecules, is thought to be a pivotal process in the pathogenesis of psoriasis. Following this notion, specifically targeting leukocyte trafficking remains an attractive approach for the treatment of psoriasis. It is increasingly recognized that during the pathogenesis of psoriasis not only effector T cells play important roles, but also multiple interactions between T cells, dendritic cells, macrophages, mast cells, endothelial cells, and keratinocytes are crucial for the full-fledged development of psoriasis. Meanwhile, the first biologics specifically inhibiting key molecules involve... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746513 Sun, 31 Aug 2008 10:58:31 +0100 1746513 http://www.medworm.com/index.php?rid=1746512&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755373%26dopt%3DAbstract Authors: Homey B, Meller S In recent years, our knowledge of the immunopathogenesis of chronic inflammatory skin diseases has increased significantly. Accumulating evidence indicates that the complex interaction of structural cells, in particular keratinocytes and endothelial cells, with skin-infiltrating leukocytes is key to our understanding of psoriasis. The recruitment of pathogenic leukocyte subsets into the skin represents a prerequisite for the initiation and maintenance of psoriasis vulgaris and is mediated by a complex chemokine and cytokine network. Results of recent studies associating cytokines and chemokines with a psoriatic phenotype are outlined herein, and their role as therapeutic targets in psoriasis is discussed in detail. PMID: 18755373 [PubMed - in process] (So... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746512 Sun, 31 Aug 2008 10:58:28 +0100 1746512 http://www.medworm.com/index.php?rid=1746511&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755374%26dopt%3DAbstract Authors: Halverstam CP, Lebwohl M Although most psoriasis patients respond to standard therapies, many circumstances warrant the use of nonstandard or off-label treatments. For instance, patients with treatment-resistant psoriasis or those who have had multiple adverse effects to other therapies may be good candidates for off-label treatments. Similarly, patients with unusual and hard-to-treat forms of psoriasis such as pustular psoriasis and palmoplantar psoriasis or specific comorbidities may benefit from certain nonstandard therapies. Drugs that may be used as alternatives to standard therapies include mycophenolate mofetil, tacrolimus or pimecrolimus, isotretinoin, colchicine, sulfasalazine, paclitaxel, dapsone, azathioprine, and hydroxyurea. Other unconventional therapies include ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746511 Sun, 31 Aug 2008 10:58:25 +0100 1746511 http://www.medworm.com/index.php?rid=1746510&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755375%26dopt%3DAbstract Authors: Kimball AB, Kupper TS Advances in the understanding and treatment of psoriasis in the past several years have been remarkable. New frontiers include better understanding the immunologic pathways that underlie the disease and the development of personalized strategies to maximize the benefit and minimize the risk for patients. Although a cure may not be imminent, there are some strategies under examination that may lead us closer to this goal. PMID: 18755375 [PubMed - in process] (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746510 Sun, 31 Aug 2008 10:58:23 +0100 1746510 http://www.medworm.com/index.php?rid=1746509&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18755376%26dopt%3DAbstract Authors: Weiss SC, Rowell R, Krochmal L It is generally accepted among dermatologists that certain skin diseases are subject to seasonal influence. This belief, however, is based primarily on anecdotal observation rather than fact-based evidence. To address this controversy, we performed a retrospective analysis of a total of 3931 subjects enrolled in 7 phase 3 clinical trials across the diseases acne, atopic dermatitis, and seborrheic dermatitis and found a seasonal effect to exist in the treatment response of the 3 very common dermatologic diseases studied. To be truly representative of a drug's benefit when the disease is known to be impacted by seasonality, efficacy figures in the package insert should therefore be based on data collected from patients enrolled across all seasons. ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=1746509 Sun, 31 Aug 2008 10:58:21 +0100 1746509