MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Clinics in Dermatology' source. Wed, 08 Feb 2012 13:12:28 +0100 http://www.medworm.com/index.php?rid=5476686&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002579%2Fabstract%3Frss%3Dyes Dermatologists have opportunities as communicators that are unique to our specialty. Consumers and patients have a never-ending hunger for information about their skin and how to keep it healthy and beautiful. Accordingly, we are sought after as speakers at medical meetings, for community gatherings, and by the media. In fact, no other medical specialty is so integrally tied to the mainstream media. According to the American Academy of Dermatology, dermatologists generated 1.4 billion media impressions in 2009. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476686 Wed, 07 Dec 2011 06:09:34 +0100 5476686 http://www.medworm.com/index.php?rid=5476685&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001088%2Fabstract%3Frss%3Dyes Abstract: This adventure in dermatology took place between 1960 and 1962. An immigration ruling forced Dr Bernard Gordon, a Canadian, to spend 2 years abroad before he could legally live and practice in the United States. Dr Gordon had just completed a 3-year residency at the New York University Skin and Cancer Unit. Dr Gordon met with his mentor, Dr Marion Sulzberger, for advice. This world-famous dermatologist took an interest in his situation and was able to arrive at an extraordinary solution. Dr Sulzberger consulted with his many dermatology colleagues and made arrangements for Dr Gordon to work abroad. He would spend 1 year in Caracas, Venezuela, teaching and conducting research in tropical skin diseases. The second year would be spent in Europe, beginning with 3 months in Madrid, Sp... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476685 Wed, 07 Dec 2011 06:09:34 +0100 5476685 http://www.medworm.com/index.php?rid=5476684&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100109X%2Fabstract%3Frss%3Dyes Abstract: Jan Mikulicz-Radecki (1850-1905) was the cofounder of modern surgery, aseptic techniques, and the inventor of gastroscopy, but his professional accomplishments go far beyond the field of surgical treatment. Various medical achievements are named in his honor, including the name of the cells that he discovered in rhinoscleroma, the name of Mikulicz disease, and the name of an ointment that he developed and continues to be used in the treatment of wounds and ulcers in surgery and dermatology. Noteworthy are also his interdisciplinary approach towards diagnosis and treatment, and his cordial attitude towards his patients. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476684 Wed, 07 Dec 2011 06:09:34 +0100 5476684 http://www.medworm.com/index.php?rid=5476683&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000940%2Fabstract%3Frss%3Dyes Abstract: Autoimmune blistering disorders are a heterogeneous group of diseases that result from autoantibodies generated against target antigens found in the skin and mucous membranes. This process leads to a variety of disruptions in keratinocyte adhesion and cellular integrity, resulting in fluid accumulation and development of blisters. Physicians should have an appreciation and understanding of autoimmune blistering disorders in the pediatric population when formulating a differential diagnosis of a patient who presents with skin blistering. Early detection and discrimination between the varied autoimmune blistering disorders can change the course of treatment and outcome. Due to the similarity in clinical presentation among different diseases within this category, histopathologic eva... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476683 Wed, 07 Dec 2011 06:09:34 +0100 5476683 http://www.medworm.com/index.php?rid=5476682&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000939%2Fabstract%3Frss%3Dyes Abstract: Scoring systems are used to assess the severity of a disease and the response to treatment. The main severity scoring indexes are the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and the Pemphigus Disease Area Index (PDAI). They have been validated and are already used in the evaluation of pemphigus and in clinical trials. They quantify disease severity by performing a global assessment of all lesions. In recent years, other severity scoring systems have been developed for pemphigus and other autoimmune blistering diseases. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476682 Wed, 07 Dec 2011 06:09:34 +0100 5476682 http://www.medworm.com/index.php?rid=5476681&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000927%2Fabstract%3Frss%3Dyes Abstract: Genetic and acquired bullous dermatoses can severely affect multiple domains of a patient's quality of life (QOL). Integrating formal evaluation of QOL into the clinical evaluation of patients facilitates an objective assessment of disease severity, mapping of disease trajectory, and captures therapeutic intervention outcomes. There have been 5 studies evaluating QOL in autoimmune dermatoses and 4 studies reviewing QOL in the genodermatoses. All literature to date indicates a significant disease burden in this setting. The development of formal QOL instruments has facilitated quantification of QOL deficits in this arena and offers promising tools for patient assessment in the future. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476681 Wed, 07 Dec 2011 06:09:34 +0100 5476681 http://www.medworm.com/index.php?rid=5476680&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000915%2Fabstract%3Frss%3Dyes Abstract: The subepidermal immunobullous diseases are a group of autoimmune blistering disorders of the skin and mucous membranes that share the common features of autoantibody deposition and blister formation at the dermal-epidermal junction or basement membrane. This group includes bullous pemphigoid, linear IgA disease, dermatitis herpetiformis, and epidermolysis bullosa acquisita, among others. Although these disorders share some common features, each disease is unique in its clinical presentation, histopathology, and immunofluorescence patterns, which allows for accurate diagnosis and disease-specific treatment strategy. Treatment of these disorders is complex and requires expert knowledge of disease pathogenesis. We review common treatment approaches for each of these disorders. (Sou... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476680 Wed, 07 Dec 2011 06:09:34 +0100 5476680 http://www.medworm.com/index.php?rid=5476679&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000903%2Fabstract%3Frss%3Dyes Abstract: Treatment of pemphigus patients is still challenging and, in some cases, conventional therapy with systemic corticosteroids in combination with adjuvant corticosteroid-sparing immunosuppressive drugs is not sufficient to induce clinical remission. More recently, high-dose intravenous immunoglobulins, immunoadsorption, and the monoclonal anti-CD20 antibody, rituximab, have been established as additional successful therapeutic options. This contribution covers both conventional therapies and most current treatment strategies for pemphigus. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476679 Wed, 07 Dec 2011 06:09:34 +0100 5476679 http://www.medworm.com/index.php?rid=5476678&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000897%2Fabstract%3Frss%3Dyes Abstract: Adjuvant immunosuppressive drugs are widely used to minimize corticosteroid-related adverse effects in the short-term and long-term management of cautoimmune bullous diseases. In bullous pemphigoid and pemphigus vulgaris, azathioprine and mycophenolate mofetil seem to be equally effective when used in combination with oral corticosteroids, but mycophenolate mofetil is less myelosuppressive and hepatotoxic. Due to a better safety profile, mycophenolate mofetil or enteric-coated mycophenolate sodium may gradually replace azathioprine as the first-line adjuvant of choice in the treatment of moderate to severe autoimmune bullous diseases, including epidermolysis bullosa acquisita and cicatricial pemphigoid. Cyclophosphamide still has a place in the treatment of severe relapsing autoi... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476678 Wed, 07 Dec 2011 06:09:34 +0100 5476678 http://www.medworm.com/index.php?rid=5476677&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000885%2Fabstract%3Frss%3Dyes Abstract: Epidermolysis bullosa (EB) is a group of inherited, mechanobullous disorders caused by mutations in various structural proteins in the skin. There have been several advances in the classification of EB since it was first introduced in the late 19th century. We now recognize four major types of EB, depending on the location of the target proteins and level of the blisters: EB simplex (epidermolytic), junctional EB (lucidolytic), dystrophic EB (dermolytic), and Kindler syndrome (mixed levels of blistering). This contribution will summarize the most recent classification and discuss the molecular basis, target genes, and proteins involved. We have also included new subtypes, such as autosomal dominant junctional EB and autosomal recessive EB due to mutations in the dystonin (DST) ge... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476677 Wed, 07 Dec 2011 06:09:34 +0100 5476677 http://www.medworm.com/index.php?rid=5476676&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000873%2Fabstract%3Frss%3Dyes Abstract: Epidermolysis bullosa acquisita (EBA) is a rare, acquired, chronic subepidermal bullous disease of the skin and mucosa characterized by autoantibodies to type VII collagen (C7) structures, a major component of anchoring fibrils, which attach the epidermis to the dermis. EBA patients have tissue-bound and circulating antitype C7 autoantibodies that attack type C7 and result in a reduction or perturbation of normally functioning anchoring fibrils. Patients with EBA have skin fragility, blisters, erosions, scars, milia, and nail loss, all features reminiscent of genetic dystrophic epidermolysis bullosa. These immunoglobulin G antitype C7 antibodies are pathogenic, because when they are injected into mice, the mice develop an EBA-like blistering disease. In addition to the classical ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476676 Wed, 07 Dec 2011 06:09:34 +0100 5476676 http://www.medworm.com/index.php?rid=5476675&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000861%2Fabstract%3Frss%3Dyes Abstract: Dermatitis herpetiformis (DH) is a chronic, polymorphic, pruritic skin disease that develops mostly in patients with latent gluten-sensitive enteropathy. DH patients usually present with skin manifestations only and are not aware of the underlying small-bowel problems. Owing to the granular immunoglobulin (Ig) A deposition at the tips of the papillary dermis and to the subepidermal blister formation associated with neutrophilic accumulations underlying the basement membrane, DH is considered to be an autoimmune blistering disease. Contrary to the other bullous disorders, DH patients have no circulating autoantibodies binding to the cutaneous basement membrane components or to other adherent structures of the skin, but they have gluten-induced IgA autoantibodies against transgluta... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476675 Wed, 07 Dec 2011 06:09:34 +0100 5476675 http://www.medworm.com/index.php?rid=5476674&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100085X%2Fabstract%3Frss%3Dyes Abstract: Pemphigoid gestationis is a rare autoimmune subepidermal bullous dermatosis that occurs during pregnancy and postpartum. Diagnosis is made on the basis of the presence of a subepidermal vesicle on routine histologic examination and of linear deposition of complement along the basement membrane zone of perilesional skin. The disorder is accompanied by severe pruritus and polymorphous bullous skin lesions. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence and immunoelectron microscopy tests (linear deposition of C3, with or without immunoglobulin G, along the basement membrane zone, within the lamina lucida, and localized to the proximal part of anchoring filaments of the epidermal fragment of salt-split skin). Enzyme-linked immunosorbent assay ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476674 Wed, 07 Dec 2011 06:09:34 +0100 5476674 http://www.medworm.com/index.php?rid=5476673&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000848%2Fabstract%3Frss%3Dyes Abstract: Linear immunoglobulin A (IgA) bullous dermatosis, also known as linear IgA disease, is an autoimmune mucocutaneous disorder characterized by subepithelial bullae, with IgA autoantibodies directed against several different antigens in the basement membrane zone. Its immunopathologic characteristic resides in the presence of a continuous linear IgA deposit along the basement membrane zone, which is clearly visible on direct immunofluorescence. This disorder shows different clinical features and distribution when adult-onset of linear IgA disease is compared with childhood-onset. Diagnosis is achieved via clinical, histopathologic, and immunopathologic examinations. Two common therapies are dapsone and sulfapyridine, which reduce the inflammatory response and achieve disease remissi... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476673 Wed, 07 Dec 2011 06:09:34 +0100 5476673 http://www.medworm.com/index.php?rid=5476672&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000836%2Fabstract%3Frss%3Dyes Abstract: Mucous membrane pemphigoid, a heterogeneous group of autoimmune blistering diseases, affects primarily the mucous membranes. Although oral and ocular mucosae can both be affected in a given patient, patients with involvement restricted to oral mucosae tend to have a benign outcome, whereas those with ocular disease commonly face treatment resistance, resulting in scarring and blindness. Diagnosis requires direct immunofluorescence microscopy to demonstrate a linear deposition of immunoglobulin (Ig) G or IgA, or complement component 3 (C3), at the epithelial basement membrane. Although the target antigens vary, subsets of patients affected exclusively by oral and ocular mucosal diseases have autoantibodies targeting α-6 and β-4 integrins, respectively. (Source: Clinics in Dermat... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476672 Wed, 07 Dec 2011 06:09:34 +0100 5476672 http://www.medworm.com/index.php?rid=5476671&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000824%2Fabstract%3Frss%3Dyes Abstract: The presence of one autoimmune disorder helps lead to the discovery of other autoimmune conditions. It is thought that diseases in which autoimmunity is a feature tend to be associated together more often than one can ascribe to chance. A variety of diseases have been implicated in the onset of intraepidermal and subepidermal autoimmune diseases. The presence of one autoimmune disease should alert the physician to watch for a second immunologic disorder. A list of autoimmune bullous diseases associations includes autoimmune bullous diseases, pemphigus, pemphigoid, epidermolysis bullosa acquisita, dermatitis herpetiformis (Duhring), linear immunoglobulin A disease, and multiple autoimmune syndrome. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476671 Wed, 07 Dec 2011 06:09:34 +0100 5476671 http://www.medworm.com/index.php?rid=5476670&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000812%2Fabstract%3Frss%3Dyes Abstract: Bullous pemphigoid (BP) constitutes the most frequent autoimmune subepidermal blistering disease. It is associated with autoantibodies directed against the BP antigens 180 (BP180, BPAG2) and BP230 (BPAG1-e). The pathogenicity of anti-BP180 antibodies has been convincingly demonstrated in animal models. The clinical features of BP are extremely polymorphous. The diagnosis of BP critically relies on immunopathologic findings. The recent development of novel enzyme-linked immunosorbent assays has allowed the detection of circulating autoantibodies with relatively high sensitivity and specificity. Although potent topical steroids have emerged in the past decade as first-line treatment of BP, management of the disease may be challenging. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476670 Wed, 07 Dec 2011 06:09:34 +0100 5476670 http://www.medworm.com/index.php?rid=5476669&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000800%2Fabstract%3Frss%3Dyes In this second of a two-part issue, Bullous Disease, we address those diseases associated with subepidermal blistering. The bullous pemphigoid (BP) group represents subepidermal autoimmune blistering diseases with three clinical variants: BP, mucous membrane pemphigoid (MMP), and pemphigoid gestationis. The autoimmune response in BP is directed against two hemidesmosomal antigens: BP180 (BP antigen 2 or collagen XVII) and BP230 (BP antigen 1). Multiple antigens are included in MMP: BP180, BP230, laminin-5, laminin-6, and the integrin B4 subunit. Autoantibodies in pemphigoid gestationis are mainly reactive with BP180. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476669 Wed, 07 Dec 2011 06:09:34 +0100 5476669 http://www.medworm.com/index.php?rid=5476668&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11003026%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476668 Wed, 07 Dec 2011 06:09:34 +0100 5476668 http://www.medworm.com/index.php?rid=5476667&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002999%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5476667 Wed, 07 Dec 2011 06:09:34 +0100 5476667 http://www.medworm.com/index.php?rid=5336001&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002057%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5336001 Sat, 22 Oct 2011 04:59:17 +0100 5336001 http://www.medworm.com/index.php?rid=5336000&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000046%2Fabstract%3Frss%3Dyes Parts 1 and 2 in this series focused on Maimonides as a man and as a general physician, two qualities in which he was exceptional. Although many of his concepts are outdated and must be put into their historical context, Maimonides' studies on dermatology are, nevertheless, notable for their rationalism, as well as by their holistic interpretation of the disease in patients who are, above all, human beings. Also, as in the rest of his medical practice, prevention of skin disease played a crucial role. This installment, therefore, will address his contribution to what would be considered dermatology. Part of his writtings also incorporate some knowledge from the works by Galen and Hippocrates. Maimonides commented on such works, and also added his own observations. (Source: Clinics in Derma... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5336000 Sat, 22 Oct 2011 04:59:17 +0100 5336000 http://www.medworm.com/index.php?rid=5335999&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002355%2Fabstract%3Frss%3Dyes Abstract: Medicine evolved in parallel with religion. Its practitioners developed their skills by selection, training, and culling. Codes of loyalties, behavior, and ethics emerged. This made them distinct.In common with government and politics, medicine has to do with the common weal. Still, the relationship of patients with physicians is based on a different kind of agreement than that with government or politics. Although physicians must participate in specific functions of government and politics related to their tasks, they act as a body that has specific limitations and rights (fuero). This is the backbone of medicine as a profession.Current tendencies favor the strengthening of governments and economic realities tend to favor the submission of physicians to those that control means ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335999 Sat, 22 Oct 2011 04:59:17 +0100 5335999 http://www.medworm.com/index.php?rid=5335998&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002379%2Fabstract%3Frss%3Dyes Abstract: In contemporary medicine, the erythrocyte sedimentation rate (ESR) is used to assess severity in patients with such diseases as erysipelas, psoriasis, eosinophilic fasciitis, dermatomyositis, and Behçet's disease. We remember the scientific achievements of a Polish physician, the discoverer of the erythrocyte sedimentation rate (ESR), Edmund Faustyn Biernacki (1866-1911), on the 100th anniversary of his death. The practical application of ESR in clinical diagnostics in 1897 by Biernacki was little known for many years, because it was often neglected owing to the work of Robert Fåhraeus and Alf Westergren from 1921. In addition, it is also frequently omitted that before Westergren's and Fåhraeus's reports were published, ESR was also noticed by Ludwig Hirschfeld in 1917. (Sourc... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335998 Sat, 22 Oct 2011 04:59:17 +0100 5335998 http://www.medworm.com/index.php?rid=5335997&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002148%2Fabstract%3Frss%3Dyes Abstract: Modern aesthetic laser technology treatment options offer minimally invasive, more affordable alternatives to traditional cosmetic surgery, with the promise of reduced downtime for the patient. Laser therapy can significantly improve the appearance of the skin; however, these procedures also carry potential risks. This contribution will provide a brief overview of current treatment modalities and review potential complications. Emphasis will be on placed on achieving best practices for the prevention of undesired outcomes and optimizing clinical management if complications occur. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335997 Sat, 22 Oct 2011 04:59:17 +0100 5335997 http://www.medworm.com/index.php?rid=5335996&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002094%2Fabstract%3Frss%3Dyes Abstract: Injection of neurotoxins and filling agents for the treatment of facial aesthetics has increased dramatically during the past few decades due to an increased interest in noninvasive aesthetic improvements. An aging but still youth-oriented population expects effective treatments with minimal recovery time and limited risk of complications. Injectable neurotoxins and soft tissue stimulators and fillers have filled this niche of “lunch-time” procedures. As demand for these procedures has increased, supply has followed with more noncore cosmetic specialty physicians, as well as unsupervised ancillary staff, becoming providers and advertising them as easy fixes. Despite an excellent record of safety and efficacy demonstrated in scores of published studies, injectable agents do ca... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335996 Sat, 22 Oct 2011 04:59:17 +0100 5335996 http://www.medworm.com/index.php?rid=5335995&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002161%2Fabstract%3Frss%3Dyes Abstract: Cutaneous procedures are associated with a wide variety of potential risks. This contribution discusses risk-related considerations in the preoperative, intraoperative, and postoperative management of dermatologic surgery patients. In the preoperative setting, major considerations include bleeding risks, the presence of pacemakers or defibrillators, risks of local and systemic infection, and the possibility of adverse reactions to local anesthetics and topical agents used for dermatologic procedures. Risk is minimized intraoperatively through careful attention to sterile technique, maintaining adequate hemostasis, skillful management of emerging complications, and effective closure of surgical defects. To optimize outcomes, postoperative priorities include effective management of... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335995 Sat, 22 Oct 2011 04:59:17 +0100 5335995 http://www.medworm.com/index.php?rid=5335994&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100215X%2Fabstract%3Frss%3Dyes Abstract: Occupation-induced skin reactions are not infrequently observed in the pharmaceutical industry. Workers may come in contact with irritant substances and also with chemically reactive intermediates or drugs that may be potential sensitizers. The skin lesions can be located at the site of contact, usually the hands, although airborne reactions on exposed and even nonexposed areas (eg, by particles trapped under clothing) are not uncommon. Generalized reactions may occur due to inhalation or transcutaneous absorption. An accidental exposure to a highly allergenic compound may cause a chemical burn, followed by primary sensitization and allergic contact dermatitis. The pharmaceutical contact allergens belong to many different pharmacologic classes. If several cases of contact dermati... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335994 Sat, 22 Oct 2011 04:59:17 +0100 5335994 http://www.medworm.com/index.php?rid=5335993&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002306%2Fabstract%3Frss%3Dyes Abstract: Isotretinoin has revolutionized the field of dermatology, offering a cure for severe acne vulgaris and a therapeutic option for a variety of other chronic diseases and cancers. This drug has done more for many diseases in medicine than many drug classes have done for a single disorder, and yet, its use and availability have been threatened in the United States. Federal restrictions in the form of the IPLEDGE teratogenicity prevention plan have made the use of this drug more complex. Millions of dollars in litigation and claims of injury have fueled hysteria among laymen about the use of this drug. Overwhelmed with worries of its potential adverse effects, the public forgets that withholding isotretinoin therapy is not without its own risks. Isoteretinoin therapy can prevent lifel... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335993 Sat, 22 Oct 2011 04:59:17 +0100 5335993 http://www.medworm.com/index.php?rid=5335992&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002318%2Fabstract%3Frss%3Dyes Abstract: Ultraviolet (UV) radiation is an established carcinogen that causes skin cancers and other cutaneous photodamage. Vitamin D is produced in the skin after UV exposure and may also be obtained from dietary and supplemental sources. The effect of recommendations for UV protection, as well as for very large vitamin D supplements, and possible adverse effects of both are explored. Current evidence supports the conclusion that protection from UV radiation reduces the incidence of skin cancers and photodamage, but generally does not compromise vitamin D status or lead to iatrogenic disease. Conversely, risks of maintaining very high vitamin D levels have not been adequately studied. Vitamin D obtained from diet and supplements is functionally identical to that produced after UV exposure... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335992 Sat, 22 Oct 2011 04:59:17 +0100 5335992 http://www.medworm.com/index.php?rid=5335991&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100232X%2Fabstract%3Frss%3Dyes Abstract: Over the past several decades, improved technologies used in the care of hospitalized and outpatient pediatric populations have resulted in a decreased but still significant number of iatrogenic injuries. Children at the highest risk for cutaneous injury include those with the most immature skin barriers, such as neonates younger than 32 weeks of gestational age. Additional risk factors include low birth weight, increased length of hospital stay, and indwelling instrumentation. Also at risk are older children with compromised skin barriers owing to infectious disease (staphylococcal scalded skin syndrome), inflammatory disease (atopic dermatitis), drug eruptions, and inherited or acquired blistering disorders. This review highlights the presentation, course, and management of iat... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335991 Sat, 22 Oct 2011 04:59:17 +0100 5335991 http://www.medworm.com/index.php?rid=5335990&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002100%2Fabstract%3Frss%3Dyes Abstract: Iatrogenic skin injuries in hospitalized patients range from drug-related complications to those related to procedures. Common drug complications include drug reaction with eosinophilia and systemic symptoms (DRESS), linear immunoglobulin (Ig) A bullous dermatosis, Stevens-Johnson syndrome/toxic epidermal necrolysis, and acute generalized exanthematous pustulosis. Contact dermatitis can result from surgical preparations of chlorhexidine and povidone-iodine, medical adhesives, topical postsurgical ointments, most commonly neomycin and bacitracin, and internal prostheses, including coronary stents, pacemakers, and metal joints. Complications arising from procedures include thrombosis caused by placement of peripherally inserted central catheters, pyoderma gangrenosum from sites of ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335990 Sat, 22 Oct 2011 04:59:17 +0100 5335990 http://www.medworm.com/index.php?rid=5335989&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002069%2Fabstract%3Frss%3Dyes We present a review of the iatrogenic effects associated with use of the biologic agents in psoriasis. Focus is placed on antitumor necrosis factor agents, because they are the most studied and commonly used agents, as well as T-cell modulators and interleukin inhibitors. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335989 Sat, 22 Oct 2011 04:59:17 +0100 5335989 http://www.medworm.com/index.php?rid=5335988&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002136%2Fabstract%3Frss%3Dyes Abstract: Patients with autoimmune and inflammatory conditions often receive long-term immunosuppressive therapy. Some of the largest patient populations with iatrogenic immunosuppression include patients who have received solid-organ transplants or who have rheumatoid arthritis or psoriasis. Although treatments improve patient outcomes, individuals with immunosuppression subsequently may have an increased risk of skin cancer, including squamous cell carcinoma, basal cell carcinoma, and malignant melanoma. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335988 Sat, 22 Oct 2011 04:59:17 +0100 5335988 http://www.medworm.com/index.php?rid=5335987&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002367%2Fabstract%3Frss%3Dyes Abstract: Chemotherapy and its cutaneous side effects are an increasingly common source of iatrogenic injury to the skin, hair, and nails. Cutaneous changes are among the most common side effects from treatment with particular targeted chemotherapeutic agents, especially those that target the epidermal growth factor receptor and small molecule multikinase inhibitors. Less common, but growing in recognition, are the development of secondary cutaneous neoplasms and subacute cutaneous lupus erythematosus as a result of chemotherapy. There is considerable overlap of the multiple entities described as a side effect from conventional chemotherapeutic agents; therefore, the term “toxic erythema of chemotherapy” can be used as an easily understood name. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335987 Sat, 22 Oct 2011 04:59:17 +0100 5335987 http://www.medworm.com/index.php?rid=5335986&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002343%2Fabstract%3Frss%3Dyes Man is never nearer the Divine than in his compassionate moments The calling of medicine comes from the human desire to help alleviate others' suffering and to overcome with compassion the bodily hardships faced by humanity. Unfortunately, in our efforts to help our patients manage disease, we must sidestep the many possible adverse injuries that may be incurred through our ministrations. Although we may be nearer to the Divine through our ministrations, the iatrogenic injuries we inadvertently cause are proof positive of our humanity, not our divinity. In this issue of Clinics in Dermatology, we focus on the topics involving iatrogenic skin injury and how to best recognize and avoid these pitfalls in therapy. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335986 Sat, 22 Oct 2011 04:59:17 +0100 5335986 http://www.medworm.com/index.php?rid=5335985&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002483%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335985 Sat, 22 Oct 2011 04:59:17 +0100 5335985 http://www.medworm.com/index.php?rid=5335984&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11002458%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5335984 Sat, 22 Oct 2011 04:59:17 +0100 5335984 http://www.medworm.com/index.php?rid=5144031&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001696%2Fabstract%3Frss%3Dyes Providing supplements to the history of dermatology bibliographic record has been a continuous project for the past 4 decades. When the endeavor was initiated, the original authors decided that only contributions in English and those directly related to dermatology, excluding sexually transmitted diseases as such, would be indexed. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144031 Sat, 20 Aug 2011 15:44:26 +0100 5144031 http://www.medworm.com/index.php?rid=5144030&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001702%2Fabstract%3Frss%3Dyes In the contribution “Constantine the Great and leprosy: fact or fiction?” in the January/February 2009 issue (2009;27:139-141; doi:10.1016/j.clindermatol.2007.08.020), the author line is incorrect as printed. The corrected author information appears below. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144030 Sat, 20 Aug 2011 15:44:26 +0100 5144030 http://www.medworm.com/index.php?rid=5144029&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000034%2Fabstract%3Frss%3Dyes Part 1 of this series focused on the figure of Maimonides as a man, describing many of the events that he faced throughout his life. This personal history forged him into the exceptional doctor he became and informs his philosophy, the type of medicine he practiced, and the unique style in practicing medicine he conceived. The current contribution will discuss his philosophy and contributions to medicine in general before presenting his contributions to the field of dermatology in Part 3. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144029 Sat, 20 Aug 2011 15:44:26 +0100 5144029 http://www.medworm.com/index.php?rid=5144028&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000908%2Fabstract%3Frss%3Dyes Robert Willan, the father of modern dermatology () was born in 1757 to a Quaker family in Yorkshire, England. His father was a well-respected physician in Yorkshire and influenced Willan in both medicine and Quaker tradition. Willan Senior moved to Philadelphia in 1848 with financial help and recommendation to Quaker friends from the respected Quaker physician in London, Dr. John Fothergill (1712-1780). In 1753, he returned to England married and settled at “The Hill”, where he spent the rest of his life and where in 1757 Willan Junior was born. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144028 Sat, 20 Aug 2011 15:44:25 +0100 5144028 http://www.medworm.com/index.php?rid=5144027&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002658%2Fabstract%3Frss%3Dyes Abstract: Within the past two decades, an exponential number of publications have emerged on the topic of dermatoscopy, most, if not all, reporting the benefits of using a dermatoscope. Dermatoscopy has been promoted to be useful in diagnosing not only pigmented skin lesions but also a wide range of skin conditions that are infectious, hamartomatous, and inflammatory in nature. Whether or not dermatoscopy truly has a relevant diagnostic role in such a wide range of skin conditions remains to be proven. The diagnostic technique, however, has fundamentally changed the way pigmented lesions are evaluated by dermatologists, as it offers a more methodical and disciplined approach to evaluate them. This review highlights the contribution of dermatoscopy with respect to morphologic characterizati... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144027 Sat, 20 Aug 2011 15:44:25 +0100 5144027 http://www.medworm.com/index.php?rid=5144026&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001756%2Fabstract%3Frss%3Dyes Abstract: Although most skin diseases can be diagnosed with simple visual inspection, laboratory investigations are necessary in several clinical circumstances. This contribution highlights the usefulness of routine diagnostic procedures that are often overlooked and the innovative methods of molecular biology, which are expensive and require an experienced staff. Among the classic diagnostic investigations are (1) the use of Wood's light in many dermatologic disorders (eg, vitiligo, pityriasis versicolor, erythrasma, porphyrias), (2) cytodiagnosis of Tzanck in dermatologic practice (eg, herpetic infections, molluscum contagiosum, leishmaniasis, pemphigus vulgaris, basal cell carcinoma, erythroplasia of Queyrat, Hailey-Hailey disease), and (3) microscopic examination for fungal and bacteri... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144026 Sat, 20 Aug 2011 15:44:24 +0100 5144026 http://www.medworm.com/index.php?rid=5144025&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001744%2Fabstract%3Frss%3Dyes Abstract: Paraneoplasias are frequently the first sign of a subjacent malignant tumor. Although relatively rare, they need to be recognized by dermatologists to make an early diagnosis and improve the prognosis related especially to the neoplasia. This contribution presents the morphologic aspects and the differential diagnosis of the main paraneoplasias, which include acanthosis nigricans, tripe palms, Leser-Trélat sign, acquired ichthyosis, acquired hypertrichosis lanuginosa, pityriasis rotunda, erythema gyratum repens, palmo-plantar keratoderma, Bazex syndrome, and dermatomyositis, hoping to contribute to the familiarity of dermatologists with the identification and early diagnosis of this group. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144025 Sat, 20 Aug 2011 15:44:24 +0100 5144025 http://www.medworm.com/index.php?rid=5144024&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001732%2Fabstract%3Frss%3Dyes Abstract: The skin should not be considered as an isolated organ but rather as a definite functioning system that communicates with the internal environment. Skin signs of systemic diseases occur frequently and sometimes feature the first symptoms of an internal disease; furthermore, these manifestations may be the sole expressions of otherwise asymptomatic systemic disorders. A number of dermatologic signs, symptoms, and disorders can be invaluable as markers of systemic disease. Although a plethora of specialized modern diagnostic tests are available, the skin still remains the only organ of the body that is immediately and completely accessible to direct clinical examination. This contribution reviews the skin signs of systemic diseases. The description of the clinical features of skin ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144024 Sat, 20 Aug 2011 15:44:24 +0100 5144024 http://www.medworm.com/index.php?rid=5144023&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001719%2Fabstract%3Frss%3Dyes Abstract: An Internet search has provided many examples of mnemonics. These are readily available, so we thought of composing new mnemonics that included information about the authors who first described the disease or are associated with the disease in question. We found this a pleasurable experience, because one of the authors (C.S.) either knew or knew of many of those who were responsible for the first writing of the diseases. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144023 Sat, 20 Aug 2011 15:44:24 +0100 5144023 http://www.medworm.com/index.php?rid=5144022&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000459%2Fabstract%3Frss%3Dyes Abstract: Commonly used dermatologic eponyms and characteristic skin signs are enormously helpful in guiding a diagnosis, even though they may not be pathonemonic. They include, on the nails, Aldrich-Mees' lines (syn.: Mees' lines), Beau's lines, Muehrcke's lines, Terry's nails, and half and half nails, often associated, respectively, with arsenic poisoning, acute stress or systemic illness, severe hypertension, liver disease and uremia, and, around the nails, Braverman's sign, associated with collagen-vascular disease. Elsewhere, one may see the Asboe-Hansen and Nikolsky's signs, indicative of the pemphigus group of diseases, Auspitz's sign, a classic finding in psoriasis, Borsieri's and Pasita's signs, seen in early scarlet fever, the butterfly rash, indicative of systemic lupus erythema... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144022 Sat, 20 Aug 2011 15:44:23 +0100 5144022 http://www.medworm.com/index.php?rid=5144021&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001707%2Fabstract%3Frss%3Dyes Abstract: Lesions that may present in a grouped way include diseases with grouped vesicles such as dyshidrosis, nummular dermatitis, herpes simplex, and herpes zoster; diseases with grouped vesicobullae such as dermatitis herpetiformis, herpes gestationis, subacute lupus erythematosus in the bullous variant, and pemphigus herpetiformis; and diseases with grouped pustules such as pustular psoriasis, dermatitis continua of Hallopeau, and impetigo herpetiformis. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144021 Sat, 20 Aug 2011 15:44:23 +0100 5144021 http://www.medworm.com/index.php?rid=5144020&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001720%2Fabstract%3Frss%3Dyes Abstract: What is probably the first description of targetoid or iris lesions, as they appear in erythema multiforme (EM), can be found in Thomas Bateman's 1836 textbook “Practical Synopsis of Cutaneous Diseases According to the Arrangement of Dr. Willan.” EM was initially described by Bateman and later by von Hebra as an acute self-limiting skin disease, symmetrically distributed on the extremities with typical concentric “targetoid” or “iris” lesions, and often recurrent. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were added to this syndrome later. A newer classification has created two disease spectra: EM consisting of EM minor and EM major (or bullous EM), and SJS and TEN. EM minor and EM major are often recurrent, postinfectious (especially after h... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144020 Sat, 20 Aug 2011 15:44:22 +0100 5144020 http://www.medworm.com/index.php?rid=5144019&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001690%2Fabstract%3Frss%3Dyes Abstract: The skin gives us an opportunity to study pathologies unapparent in other systems such as patterned disorders. Among the best-identified patterns of skin disorders are the well-known lines of Blaschko, but other types of skin-patterned lesions have also been recognized. This short review will describe and discuss these different patterns and their pathophysiologic mechanisms, such as somatic mosaicism and X-chromosome associated mosaicism. Cutaneous patterned disorders are thought to be associated usually with inherited diseases per se, but in fact they are also reported in so-called acquired diseases. These cases suggest the existence of an underlying defect in a gene closely associated with the disease pathogenesis. The study of these acquired patterned disorders in the future ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144019 Sat, 20 Aug 2011 15:44:22 +0100 5144019 http://www.medworm.com/index.php?rid=5144018&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001689%2Fabstract%3Frss%3Dyes Abstract: Dermatologists are called on to diagnose a variety of skin conditions in diverse age groups. Dermatologic diagnosis, based on identification of a primary lesion, uses morphologic clues to categorize the pathologic process causing the eruption. In addition, distribution and grouping of lesions helps support a specific diagnosis. Dermatologists consciously or unconsciously use pattern recognition to arrive at their differential diagnosis based on clinical experience and their having previously viewed similarly appearing skin lesions in lectures, texts, and journals. Round and discoid patches and plaques are extremely common in the clinical practice of dermatology. This contribution reviews the dermatologic conditions that present as round or discoid lesions and presents an approach... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144018 Sat, 20 Aug 2011 15:44:22 +0100 5144018 http://www.medworm.com/index.php?rid=5144017&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000794%2Fabstract%3Frss%3Dyes Abstract: Genetic, developmental, and immune defects can make certain anatomic areas of the body more prone than others to harbor skin lesions. Cutaneous areas with skin barrier dysfunction (eg, atopic dermatitis) are the clearest example of vulnerable sites where opportunistic diseases, mainly infections (eg, herpes simplex), can easily occur. Somatic mosaicism, by giving rise to mutated cell clones with a bandlike arrangement, may form tissue segments prone to developing congenital or acquired skin disorders. Cutaneous districts that have been infected by herpes viruses become sites permissive for a subsequent onset of heterogeneous skin disorders, mainly tumors, further infections, and disimmune reactions (Wolf isotopic response). Regional lymphedema, by impairing lymph circulation and ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144017 Sat, 20 Aug 2011 15:44:22 +0100 5144017 http://www.medworm.com/index.php?rid=5144016&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001064%2Fabstract%3Frss%3Dyes What is hardest of all? That which seems most simple: to see with your eyes what lies in front of your eyes Johann Wolfgang von Goethe (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144016 Sat, 20 Aug 2011 15:44:22 +0100 5144016 http://www.medworm.com/index.php?rid=5144015&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100174X%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144015 Sat, 20 Aug 2011 15:44:22 +0100 5144015 http://www.medworm.com/index.php?rid=5144014&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001726%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=5144014 Sat, 20 Aug 2011 15:44:22 +0100 5144014 http://www.medworm.com/index.php?rid=4937071&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000435%2Fabstract%3Frss%3Dyes In Habif's updated fifth edition of Clinical Dermatology: A Color Guide to Diagnosis and Therapy, the reader is introduced to this valuable reference with a guide on how to best use the book, based on the reader's knowledge of dermatology. This introduction accurately depicts this reference as an illustrated manual suitable for clinicians of all levels. From student to primary care physician, from dermatologists still in training to beyond, anyone with an interest in dermatology will find this to be a valuable and suitable resource. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937071 Sat, 18 Jun 2011 16:31:27 +0100 4937071 http://www.medworm.com/index.php?rid=4937070&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001052%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937070 Sat, 18 Jun 2011 16:31:27 +0100 4937070 http://www.medworm.com/index.php?rid=4937069&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002671%2Fabstract%3Frss%3Dyes Abstract: Medicine and health care in Venezuela have had a roller coaster evolution in parallel with advances and retreats of democracy and of efforts to modernize. The most prominent of the founding fathers of Venezuelan medicine has a sitting statue in the homonymous hospital. After a blossoming of medicine, health care, and research led by dermatology that lasted for nearly four decades, the system went into a tailspin that mirrors what took place in the governmental institutions and in the economy. The statue of Vargas seems to warn Venezuelans that if the decay goes too far, it may become irreversible. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937069 Sat, 18 Jun 2011 16:31:26 +0100 4937069 http://www.medworm.com/index.php?rid=4937068&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000022%2Fabstract%3Frss%3Dyes Moses Maimonides (meaning “son of Maimon” from the Greek suffix “-ides”: “son of”) was among the most well-known physicians of the Middle Ages (). Also known as Moshé ben Maimón, Musa ibn Maymun, Abu ‘Imran Musa ben Maimum ibn ‘Abd Allah, Rabi Moses the Ægyptius, ןומימןבהשמ (in Hebrew; ), نو ميم نب ىسوم (in Arabic), or RaMBaM (acronym of Rabbi Moses ben Maimon), Maimonides achieved fame through not only his immense knowledge but also his outstanding activity as a physician, theologian, philosopher, and rabbi. His impact in these fields spread to several countries during the Middle Ages and influenced many thinkers of different religions, through today. He was a person with an exceptional human understanding, conferring upon him an outstanding role in... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937068 Sat, 18 Jun 2011 16:31:26 +0100 4937068 http://www.medworm.com/index.php?rid=4937067&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001076%2Fabstract%3Frss%3Dyes Recent reviews on “The role of diet in acne: facts and controversies” and “Nutrition and acne” were interesting but may not have adequately challenged the dogma that chocolate does not exacerbate acne vulgaris. Our Medline search, using the key words “acne and chocolate,” showed that only 3 studies examined the role of chocolate consumption and acne. One clinical trial had 8 patients, another did not specify sample size, and the third study by Fulton, Plewig, and Kligman (1969) supported the oft-repeated assertion that eating chocolate has no effect on acne. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937067 Sat, 18 Jun 2011 16:31:26 +0100 4937067 http://www.medworm.com/index.php?rid=4937066&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000423%2Fabstract%3Frss%3Dyes Abstract: Pemphigus is an autoimmune bullous disease that may be influenced by genetic and exogenous factors. Drugs are a leading cause of pemphigus. There is a need for a thorough history taking so as to find the culprit medication. The diagnosis of drug-induced pemphigus is challenging. Patients have often been exposed to multiple drugs, and some drugs may have a prolonged latency period between exposure and onset of the disease. The in vitro interferon-gamma (IFN-gamma) release from lymphocytes test has been shown to be of diagnostic value in drug-induced skin reactions. Cessation of the offending drug may alleviate the clinical manifestations and reduce the need for medical treatment. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937066 Sat, 18 Jun 2011 16:31:26 +0100 4937066 http://www.medworm.com/index.php?rid=4937065&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000411%2Fabstract%3Frss%3Dyes Abstract: The oral mucosa is frequently involved by autoimmune bullous diseases and often this is the first site of manifestation. In this site the lesions are very similar, making the clinical diagnosis difficult; therefore, the definition of the immunohistopathologic characteristics of each one becomes essential for a differential diagnosis. The authors review the clinical-pathological and therapeutic aspect of these oral injuries in order to help in the diagnosis, treatment and prognosis of the oral conditions of those diseases. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937065 Sat, 18 Jun 2011 16:31:26 +0100 4937065 http://www.medworm.com/index.php?rid=4937064&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100040X%2Fabstract%3Frss%3Dyes Abstract: Pemphigus is a life-threatening autoimmune blistering disease. Pemphigus is divided into 4 major types; pemphigus vulgaris, pemphigus foliaceus, paraneoplastic pemphigus, and IgA pemphigus. Among them, IgA pemphigus is characterized by tissue-bound and circulating IgA antibodies targeting desmosomal or nondesmosomal cell surface components in the epidermis. Histopathologically, slight epidermal acantholysis and extensive neutrophilic infiltration in either the upper part or all layers of the epidermis were observed. IgA pemphigus is subdivided into intraepidermal neutrophilic IgA dermatosis-type (IEN-type), whose target antigen is still unknown (probably nondesmosomal cell surface protein), and subcorneal pustular dermatosis-type (SPD-type), whose target antigen is desmocollin 1 ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937064 Sat, 18 Jun 2011 16:31:25 +0100 4937064 http://www.medworm.com/index.php?rid=4937063&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000393%2Fabstract%3Frss%3Dyes Abstract: Pemphigus is a rare autoimmune bullous disorder involving the skin and mucosa. The disease has a chronic course. It is characterized histologically by an intraepidermal cleavage and the production of pathogenic antibodies directed against different proteins of the desmosomes, which belong to the cadherin family. The diagnosis of the type of pemphigus is made on clinical features, the level of histologic cleavage, and the identification of the antigens recognized by circulating autoantibodies using immunoblot or ELISA analysis of serum. The epidemiology and clinical, histologic, and immunologic findings of pemphigus vulgaris, pemphigus foliaceus, pemphigus vegetans, and pemphigus herpetiformis are described. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937063 Sat, 18 Jun 2011 16:31:25 +0100 4937063 http://www.medworm.com/index.php?rid=4937062&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000381%2Fabstract%3Frss%3Dyes Abstract: Adhesion molecules are proteins on the cell surface that are involved in the interactions between lymphocytes and antigen-presenting cells, especially in inflammatory skin diseases and autoimmune bullous disorders. Adhesion molecules include cadherins (subgroups E, N, P, M), integrins, selectins, and the immunoglobulin gene family. Cadherins E in the epidermis including desmocollin 1 and 2 and desmoglein 1 and 3 are essential transmembrane components of desmosome glycoproteins, which play a major role in bullous diseases, pemphigus in particular. Also important are integrin beta 1 alpha 1 and other integrins, which connect ligands of the collagen, laminin, and fibronectin. Selectins (E, P) are important for leukocyte migration on endothelial cells. Adhesion molecules from the imm... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937062 Sat, 18 Jun 2011 16:31:25 +0100 4937062 http://www.medworm.com/index.php?rid=4937061&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100037X%2Fabstract%3Frss%3Dyes Abstract: Epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders, characterized by blistering of skin and mucosal membranes under normal mechanical stress conditions. The clinical phenotype ranges from mild localized to severe generalized disease with secondary extracutaneous symptoms and premature death. The lives of the patients and their families are marked by this disorder, causing severe physical, psychologic, and material burdens. The four major EB types are classified by the level of skin blistering, but more than 30 subtypes can be distinguished, according to clinical and molecular genetic criteria. So far, mutations in 14 genes are known to cause different EB subtypes. The diagnosis of the EB subtype is essential for the prognosis, genetic counseling, and prenata... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937061 Sat, 18 Jun 2011 16:31:25 +0100 4937061 http://www.medworm.com/index.php?rid=4937060&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000368%2Fabstract%3Frss%3Dyes Abstract: Epidermolysis bullosa (EB) is classified into the three major subtypes depending on the level of skin cleavage within the epidermal keratinocyte or basement membrane zone. Tissue separation occurs within the intraepidermal cytoplasm of the basal keratinocyte, through the lamina lucida, or in sublamina densa regions of the basal lamina (basement membrane) in EB simplex, junctional EB, and dystrophic EB, respectively. Transmission electron microscopy (TEM) is an effective method for determining the level of tissue separation and hemidesmosome (HD) and anchoring fibril morphology if performed by experienced operators, and has proven to be a powerful technique for the diagnosis of new EB patients. Recent advances in genetic and immunofluorescence studies have enabled us to diagnose E... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937060 Sat, 18 Jun 2011 16:31:25 +0100 4937060 http://www.medworm.com/index.php?rid=4937059&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000356%2Fabstract%3Frss%3Dyes Abstract: The dermal-epidermal basement membrane is a complex assembly of proteins that provide adhesion and regulate many important processes such as development, wound healing, and cancer progression. This contribution focuses on the structure and function of individual components of the basement membrane, how they assemble together, and how they participate in human tissues and diseases, with an emphasis on skin involvement. Understanding the composition and structure of the basement membrane provides insight into the pathophysiology of inherited blistering disorders, such as epidermolysis bullosa, and acquired bullous diseases, such as the pemphigoid group of autoimmune diseases and epidermolysis bullosa acquisita. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937059 Sat, 18 Jun 2011 16:31:25 +0100 4937059 http://www.medworm.com/index.php?rid=4937058&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000344%2Fabstract%3Frss%3Dyes Abstract: Direct immunofluorescence study remains the diagnostic gold standard in the assessment of patients with bullous disorders, despite novel immunoserologic tests such as enzyme-linked immunosorbent assay and immunoblotting. This contribution provides an update of the classification of autoimmune bullous diseases and diagnostic procedures, with an emphasis on immunofluorescence findings. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937058 Sat, 18 Jun 2011 16:31:25 +0100 4937058 http://www.medworm.com/index.php?rid=4937057&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000332%2Fabstract%3Frss%3Dyes Abstract: The histologic picture of intraepidermal and subepidermal autoimmune bullous dermatoses is presented. Histologic changes are described according to the temporal evolution of lesions, with special reference to crucial elements of the histologic differential diagnosis. The diagnosis of autoimmune bullous dermatoses is complex, mostly requiring additional immunofluorescence assays along with histoclinical correlation to detect the antibodies or target antigen by the methods of molecular biology or immunohistochemistry. Additional tests to reach an accurate diagnosis in various autoimmune bullous dermatoses are briefly described, emphasizing the need of proper integration of all clinical and laboratory data. Although frequently inadequately specific, the histologic finding provides a... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937057 Sat, 18 Jun 2011 16:31:25 +0100 4937057 http://www.medworm.com/index.php?rid=4937056&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000320%2Fabstract%3Frss%3Dyes Abstract: The skin, the body's largest organ, helps to secure the integrity of the host and, at the same time, allows the individual to communicate with the outside world. This finely tuned balance between protection from harmful pathogens (mostly microorganisms) and bidirectional signal exchange is provided by a network of structural, cellular, and molecular elements that are collectively referred to as the skin barrier. This “gateway” has a physical, chemical, and immunologic component. The role of the latter is to elicit a powerful defense reaction in the case of danger and, at the same time, to prevent such a reaction against innocuous substances. Immune responses originating in the skin are mounted and executed by cells and molecules of the innate or the adaptive immune system. In... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937056 Sat, 18 Jun 2011 16:31:25 +0100 4937056 http://www.medworm.com/index.php?rid=4937055&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000319%2Fabstract%3Frss%3Dyes Abstract: In the not so distant past, the word pemphigus or pemphix was common for describing various diseases characterized by blistering as well as various disorders that do not originate from a blistering pathology. Patients with these conditions were grouped in “other” skin diseases. Step by step, during the past, we were introduced to these severe conditions. First, we learned from sporadic case reports, then new differentiations were reported according to histology, later immunopathology was developed, and now there are discoveries of new molecules. Immense progress with new approaches to therapy has been achieved, but much improvement is still needed. The modern definition of pemphigus undoubtedly represents a group of rare, intraepidermal autoimmune bullous diseases characteriz... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937055 Sat, 18 Jun 2011 16:31:24 +0100 4937055 http://www.medworm.com/index.php?rid=4937054&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000307%2Fabstract%3Frss%3Dyes Bullous dermatoses are characterized by vesicular-pustular eruptions and are classified by whether they are hereditary or acquired diseases. The most important of the acquired bullous skin diseases are the pemphigus group, the pemphigoid group, acquired bullous epidermolysis, and dermatitis herpetiformis. Pemphigus is a group of autoimmune blistering diseases of the skin and mucous membranes that is mediated by immunoglobulin G (IgG) antibodies against the cadherin type of cell-cell adhesion molecules in desmosomes, desmogleins. This issue is divided into two parts. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937054 Sat, 18 Jun 2011 16:31:24 +0100 4937054 http://www.medworm.com/index.php?rid=4937053&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001143%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937053 Sat, 18 Jun 2011 16:31:24 +0100 4937053 http://www.medworm.com/index.php?rid=4937052&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11001118%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4937052 Sat, 18 Jun 2011 16:31:23 +0100 4937052 http://www.medworm.com/index.php?rid=4710302&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000538%2Fabstract%3Frss%3Dyes In the article “Władysław Sylwester Kopytowski (1858-1925): His life and early description of the microabscess in psoriasis” by Andrzej Grzybowski and Stefania Jabłońska in the January/February 2011 issue (2011;29:107-112; doi: 10.1016/j.clindermatol.2010.05.001), the legend of was incorrect. The left and right sides were mismatched. The corrected legend appears below. The authors regret the error. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710302 Thu, 14 Apr 2011 16:33:56 +0100 4710302 http://www.medworm.com/index.php?rid=4710301&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001513%2Fabstract%3Frss%3Dyes Observational skills have always been the physician’s most important weapon in the diagnosis, care, and treatment of the patient. In the early 20th century, the physician was equipped primarily with a keen sense of observation and a compassionate heart; effective medications, and diagnostic laboratory tests; reliable imaging techniques were still to come. During house calls, the physician used his observational skills to evaluate both the surroundings and family members with respect to their limitations and benefits in regard to the patient. The observational skills of vision, hearing, touch, smell, and taste were well developed in most doctors. These skills were honed to razor-sharpness in the “diagnostician,” a term of honor applied to any physician, specialist, or nonspecialist, w... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710301 Thu, 14 Apr 2011 16:33:55 +0100 4710301 http://www.medworm.com/index.php?rid=4710300&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000266X%2Fabstract%3Frss%3Dyes Abstract: Dermatology began to appear as a specialty in the United States in the post-Civil War period, when there was a dramatic increase in medical knowledge, as well as in the population. The horrors of the Civil War called attention to many skin diseases. Ophthalmology and otolaryngology developed due mostly to the introduction of instrumentation, whereas dermatology grew based on observation. With the increase in urban populations, the opportunity for medical specialization and, in particular, dermatology, appeared and would be accepted. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710300 Thu, 14 Apr 2011 16:33:55 +0100 4710300 http://www.medworm.com/index.php?rid=4710299&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001549%2Fabstract%3Frss%3Dyes In 1918, after World War I, Poland obtained independence. This meant a significant development of the University of Lwów, one of the major Polish universities in that time. During the period between the world wars, Lwów, with two independent dermatology departments chaired by professors of dermatology and staffed by several assistant professors of dermatology, became one of the most important dermatology centers in Central Europe. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710299 Thu, 14 Apr 2011 16:33:55 +0100 4710299 http://www.medworm.com/index.php?rid=4710298&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002208%2Fabstract%3Frss%3Dyes Abstract: It is only by recognizing what we know that we know, and being cognizant of the things that we know that we don't know that clinicians and the health profession are able to deliver quality care to patients. Traditional learning methods can sometimes perpetuate unappraised and unfounded beliefs and practices. Evidence-based practice requires robustly conducted systematic reviews and evidence-based guidelines. There have only been three systematic reviews of occupational contact dermatitis. These inform us of what we know we know and what we know that we don't know. We know which agents cause allergic and irritant occupational contact dermatitis, and we know the occupations that present the greatest risk. We know that conditioning creams are helpful in the prevention and management... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710298 Thu, 14 Apr 2011 16:33:55 +0100 4710298 http://www.medworm.com/index.php?rid=4710297&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002191%2Fabstract%3Frss%3Dyes Abstract: The allergenicity of para-phenylenediamine (PPD) is related to oxidative processes on and in the skin. Patients with stronger reactions to PPD are significantly more likely to have a clear history of reacting to normal consumer hair dye. Those with stronger reactions are much less likely to be still dyeing their hair. Individuals allergic to PPD have a significant frequency of simultaneous sensitivity to chemically related clothing dyes. A 24-hour test application of hair dye, which has been proposed as a self-screen, does not reliably predict all individuals allergic to PPD. Duration studies have proven that exposures of 5 to 30 minutes, the period used for hair dyeing, are sufficient to elicit reactions. A significant rise in the frequency of PPD allergy was observed over 7 yea... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710297 Thu, 14 Apr 2011 16:33:55 +0100 4710297 http://www.medworm.com/index.php?rid=4710296&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000218X%2Fabstract%3Frss%3Dyes Abstract: Human skin is exposed to a large variety of cosmetic allergens. Most allergic contact dermatitis occurs after exposure to fragrance, preservatives, and hair dyes. Such reactions can often be occult. As a result, a high index of suspicion is needed in assessing the patient with facial or cosmetic dermatitis. This contribution looks at why such a large number of chemicals are in everyday usage, at how dermatologists monitor trends in allergy to cosmetics, and at a number of new and emerging allergens to consider in the assessment of suspected cosmetic allergy. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710296 Thu, 14 Apr 2011 16:33:55 +0100 4710296 http://www.medworm.com/index.php?rid=4710295&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002105%2Fabstract%3Frss%3Dyes Abstract: Allergic reactions to sunscreens are relatively rare. However, as the public become more conscious of the dangers of excessive sunlight exposure, the use of sunscreens is increasing. They are also being incorporated into general cosmetics on a more frequent basis. Sunscreens contain a variety of potential sensitizers which may lead to contact and/or photocontact allergic dermatitis, and as pharmaceutical companies continue to manufacture and incorporate new UV filters it is crucial that we remain up to date and aware of these agents to include in patch and photopatch testing batteries. Furthermore, the creation of a European consensus statement regarding methodology in photopatch testing has enabled greater standardization and comparison of patch test results across centers. (Sou... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710295 Thu, 14 Apr 2011 16:33:54 +0100 4710295 http://www.medworm.com/index.php?rid=4710294&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002178%2Fabstract%3Frss%3Dyes Abstract: Insulin reactions occur rarely but are of tremendous clinical importance. The first was reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine insulin. Porcine insulin was subsequently found to be less allergenic than bovine insulin. Increasingly pure insulins have decreased the risk of adverse reactions, and the production of recombinant insulin with the same amino sequence as human insulin saw a large decrease in adverse reactions. Currently, the prevalence of allergic reactions to insulin products appears to be approximately 2%, and less than one-third of these events have been considered related to the insulin itself. Other reactions occur due to the preservatives added to insulin, including zinc, protamine, and meta-cresol. Allergic rea... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710294 Thu, 14 Apr 2011 16:33:54 +0100 4710294 http://www.medworm.com/index.php?rid=4710293&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002166%2Fabstract%3Frss%3Dyes Abstract: Identifying contact allergens in ophthalmic medications can be a challenging and daunting experience. We summarize data on topical ophthalmic medications with the potential to cause periorbital contact dermatitis and allergic conjunctivitis, highlighting current dilemmas and controversies in this area. The following groups of allergens are reviewed: preservatives, antiglaucoma medications (prostaglandin analogues, β-blockers, carbonic anhydrase inhibitors, parasympathomimetics, sympathomimetics), antiinflammatory medications (nonsteroidal antiinflammatory drugs, corticosteroids), antibiotics, antivirals, antiallergic medications (antihistamines, cromones), anaesthetics, mydriatics, and cycloplegics. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710293 Thu, 14 Apr 2011 16:33:54 +0100 4710293 http://www.medworm.com/index.php?rid=4710292&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002154%2Fabstract%3Frss%3Dyes Abstract: Contact allergy to topical corticosteroids should be considered in all patients who do not respond to, or are made worse by, the use of topical steroids. The incidence of steroid allergy in such patients is reported as 9% to 22% in adult patients and in 25% of children. It can often go undiagnosed for a long time in patients with a long history of dermatologic conditions and steroid use. Although rare, both immediate and delayed-type hypersensitivity reactions have been reported to systemic corticosteroids with an incidence of 0.3%. Reported reactions range from localized eczematous eruptions to systemic reactions, anaphylaxis, and even death. Delayed type reactions to systemically administered steroids may present as a generalized dermatitis, an exanthematous eruption, or occasi... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710292 Thu, 14 Apr 2011 16:33:54 +0100 4710292 http://www.medworm.com/index.php?rid=4710291&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002142%2Fabstract%3Frss%3Dyes Abstract: Rubber is a ubiquitous material with a varied range of properties resulting from its manufacturing process. Rubber allergy also has various forms and is a common cause of morbidity in many occupations. This contribution discusses the main issues surrounding allergy to this compound and at each section distinguishes between type I allergy to latex (natural rubber) and type IV allergy to rubber additives. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710291 Thu, 14 Apr 2011 16:33:54 +0100 4710291 http://www.medworm.com/index.php?rid=4710290&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002130%2Fabstract%3Frss%3Dyes Abstract: Hand dermatitis can cause significant morbidity. It is not only pruritic, painful, and adversely affects manual dexterity, but it is also very visible, resulting in a substantial psychosocial and physical impact. The prevalence of hand dermatitis in the general population is 5% to 10%, and it appears to be twice as common in women than in men. Certain occupations predispose workers to hand dermatitis, especially those that require frequent hand washing or exposure to particular substances such as solvents. Hand dermatitis has a significant economic effect on society, and the socioeconomic and psychologic effect for the individual can be catastrophic. The need for effective management of this condition is, therefore, quite clear; however, historically hand dermatitis is difficult ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710290 Thu, 14 Apr 2011 16:33:53 +0100 4710290 http://www.medworm.com/index.php?rid=4710289&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002129%2Fabstract%3Frss%3Dyes Abstract: In 2009, the American Contact Dermatitis Society (ACDS) proposed a Core Allergen Series (CAS) consisting of 80 allergens. The proposed ACDS series contains many of the same allergens present in other international series, including the European Standard Series (ESS), the Extended International Series (EIS), and the British Contact Dermatitis Society (BCDS) Series; however, the number of allergens recommended in the ACDS CAS is greater than other screening series. Some notable examples of allergens included in ACDS CAS that are absent in other international series are bacitracin, benzophenone, mixed dialkyl thioureas, multiple corticosteroids, acrylates, and sorbitan sesquioleate. The ACDS CAS, conversely, omits some allergens that are included in other series such as clioquinol a... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710289 Thu, 14 Apr 2011 16:33:53 +0100 4710289 http://www.medworm.com/index.php?rid=4710288&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002117%2Fabstract%3Frss%3Dyes Abstract: Cutaneous inflammation can show Th1 or Th2 predominance, but the precise mechanisms by which such selectivity is determined are unknown. A recent study has demonstrated that Th1 cells, but not Th2 cells, produce an endogenous ligand for Toll-like receptor (TLR) 4, namely extradomain A+ fibronectin containing extra type III domain A (FnEDA+). As TLR4 stimulation leads to production of proinflammatory cytokines that recruit (via altered endothelial adhesion molecule expression and chemokine production) more Th1/Th17 cells, a positive feedback mechanism for Th1/Th17 inflammation exists. We propose that FnEDA+ positive feedback loops are a potential driver of Th1/Th17 inflammation. Conversely, the inflammatory EDA+ fibronectin loop is negatively regulated in atopic dermatitis, Th2 cy... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710288 Thu, 14 Apr 2011 16:33:53 +0100 4710288 http://www.medworm.com/index.php?rid=4710287&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002099%2Fabstract%3Frss%3Dyes The incidence of contact dermatitis continues to rise, as do the number of allergens and irritants reported as causes. In the United States (US), the National Ambulatory Medical Care Survey conducted in 1995 estimated that 8.4 million outpatient visits to American physicians each year are due to contact dermatitis. This was the second most frequent dermatologic diagnosis. Of office visits to dermatologists, 9% are for dermatitis. The rise in incidence is perhaps now most noticeable in those patients, seen with contact dermatitis to cosmetics, toiletries, and skin and hair care products. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710287 Thu, 14 Apr 2011 16:33:53 +0100 4710287 http://www.medworm.com/index.php?rid=4710286&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000587%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710286 Thu, 14 Apr 2011 16:33:53 +0100 4710286 http://www.medworm.com/index.php?rid=4710285&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000551%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4710285 Thu, 14 Apr 2011 16:33:53 +0100 4710285 http://www.medworm.com/index.php?rid=4595173&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001525%2Fabstract%3Frss%3Dyes The University of Lwów was founded in 1661 by the Polish king Jan Kazimierz. The establishment of the medical faculty was restrained for many years due to protests from the Jagiellonian University in Cracow, its major competitor. In its long history, the university was closed and reopened many times, mainly due to political circumstances. Different sorts of medical schools were affiliated with the university, but it was not until 1894 when the medical faculty was founded. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595173 Tue, 01 Mar 2011 00:00:00 +0100 4595173 http://www.medworm.com/index.php?rid=4595172&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000143%2Fabstract%3Frss%3Dyes With increasing public focus on the cost of health care and demands for greater accountability, there is an ever-increasing emphasis on measurement of quality, patient satisfaction, and outcomes. We are being challenged to create a broad array of evidence-based guidelines and quality measures for our specialty. The standards for level of evidence are continually being raised. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595172 Tue, 01 Mar 2011 00:00:00 +0100 4595172 http://www.medworm.com/index.php?rid=4595171&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001677%2Fabstract%3Frss%3Dyes We describe this entity and present representative clinical examples. Some problems in the definition of Wolf's isotopic response are provided with special emphasis on its overlapping with the Koebner isomorphic response, a similar, but different, phenomenon. Also addressed are a number of issues associated with another term, “isotopic nonresponse,” which had been introduced in analogy to the “isomorphic nonresponse” for describing the absence of an eruption at the site of another unrelated and already healed skin disease, or the sparing of the sites of another unrelated and already healed skin disease. In the spirit of the present issue, this contribution discusses only the clinical morphology and not the etiology, pathomechanism, or molecular biology of Wolf's isotopic response. ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595171 Tue, 01 Mar 2011 00:00:00 +0100 4595171 http://www.medworm.com/index.php?rid=4595170&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001665%2Fabstract%3Frss%3Dyes Abstract: The Koebner phenomenon is one of the most well-known entities in dermatology. It was first described by Heinrich Koebner in 1876 as the formation of psoriatic lesions in uninvolved skin of psoriatic patients after cutaneous trauma. This isomorphic phenomenon is now known to involve numerous diseases, among them vitiligo, lichen planus, and Darier disease. The pathogenesis of the Koebner phenomenon is still obscure but may involve cytokines, stress proteins, adhesion molecules, and autoantigens. This contribution reviews the clinical manifestations of Koebner phenomenon, its provocative factors, suggested pathogenesis mechanisms, and the various skin conditions that exhibit this unique response. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595170 Tue, 01 Mar 2011 00:00:00 +0100 4595170 http://www.medworm.com/index.php?rid=4595169&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001653%2Fabstract%3Frss%3Dyes Abstract: The traditional nomenclature of vascular lesions has been enlarged and modified with the usage of newer diagnostic techniques. Digital technology has enhanced the precision of older analog tools such as Doppler flow studies. Angiograms have also more precisely delineated flow patterns to allow planned surgical intervention as an important therapeutic option. With the newer classification, it now is possible to plan and anticipate the course of lesions and medically intervene in tumors that potentially will enlarge and impinge on essential structures. Now, the routine workup will clarify if there is internal involvement (eg, liver, etc) and detect proliferative potential mandating medical or surgical intervention. Watchful waiting, the traditional approach is now changing with the... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595169 Tue, 01 Mar 2011 00:00:00 +0100 4595169 http://www.medworm.com/index.php?rid=4595168&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001641%2Fabstract%3Frss%3Dyes Abstract: The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches without midline separation, and lateralization. We emphasize the differential diagnoses, clues to correct categorization, and associated findings of inflammatory, hypopigmented, and hyperpigmented lesions with a mosaic distribution. Clinical examples are used to illustrate genetic concepts such as functional X-chromosome mosaicism, type 1 and 2 segmental manifestations of autosomal dominant skin diseases, paradominant inheritance, and twin sp... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595168 Tue, 01 Mar 2011 00:00:00 +0100 4595168 http://www.medworm.com/index.php?rid=4595167&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000460%2Fabstract%3Frss%3Dyes Abstract: Dermatologic eruptions can be generalized or localized to specific areas of the body. Eruptions in specific body regions may suggest specific diagnosis. Recognizing such clinical patterns can facilitate the identification of the underlying pathology. In this contribution, we shall discuss those dermatologic lesions that tend to affect the flexure and extensor surfaces. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595167 Tue, 01 Mar 2011 00:00:00 +0100 4595167 http://www.medworm.com/index.php?rid=4595166&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000163X%2Fabstract%3Frss%3Dyes Abstract: Pattern analysis of skin lesions is an art and a key competence of every dermatologist. Three major line patterns cover the human body—the dermatomes or Head zones, the nevoid lines of Blaschko, and the relaxed skin tension lines, or Langer lines. Head zones represent skin areas innervated from the same sensory neuronal segment or spinal nerve zone. Blaschko lines are borderlines of epidermal aberration caused by genetic mosaicism occurring in the early stages of embryogenesis. Langer lines show the direction of the lowest naturally occurring skin tension, and its thoracodorsal manifestation is the Christmas tree pattern. Here we review clinical aspects of pityriasis rosea, mycosis fungoides, stage 2 syphilis, exanthematic Kaposi sarcoma, exanthematic psoriasis, Leser-Trelat sy... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595166 Tue, 01 Mar 2011 00:00:00 +0100 4595166 http://www.medworm.com/index.php?rid=4595165&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001628%2Fabstract%3Frss%3Dyes Abstract: A wide variety of dermatoses may arise in exposed areas and are at the same time induced or exacerbated by irradiation from the sun. The spectrum may range from acute sunburn to chronic effects of sun damage, including elastosis and ultraviolet-induced skin cancer. Inflammatory ultraviolet-induced dermatoses have a confusing nomenclature and classification that often leads to difficulties in the differential diagnosis. Modern nosology differentiates primary from secondary photodermatoses. Primary photodermatoses are believed to be mainly irradiation-induced and immunologically mediated. If the pathophysiology is not clearly defined, they are also called idiopathic. In cases of a known photosensitizer, local and systemic phototoxic or photoallergic reactions can be differentiated.... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595165 Tue, 01 Mar 2011 00:00:00 +0100 4595165 http://www.medworm.com/index.php?rid=4595164&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001616%2Fabstract%3Frss%3Dyes Abstract: Intertrigo is a superficial inflammatory skin disorder involving any area of the body where two opposing skin surfaces can touch and rub or chaff. The word “intertrigo" comes from the Latin inter (between) and terere (to rub) and reflects the rubbing together of skin against skin to create maceration and irritation, hence, friction dermatitis or chaffing. It is a common disorder that can affect any individual from infancy to old age. It is primarily caused by skin-on-skin friction and is facilitated by moisture trapped in deep skin folds where air circulation is limited. The condition is particularly common in obese patients who have diabetes and who are exposed to heat and humidity. The moist, damaged skin associated with intertrigo is a fertile breeding ground for various mic... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595164 Tue, 01 Mar 2011 00:00:00 +0100 4595164 http://www.medworm.com/index.php?rid=4595163&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001604%2Fabstract%3Frss%3Dyes Abstract: A series of skin diseases may affect the anogenital region with unusual presentations; therefore, a careful clinical approach is needed to make a correct diagnosis. Diseases of the anogenital area include inflammatory dermatoses, infectious lesions, and neoplastic conditions. Inflammatory dermatoses are frequently not restricted to the anogenital area and often occur on other sites. Infectious anogenital lesions can be easily confused with other benign or malignant processes. Tumors that arise on the anogenital skin are similar to those that occur on the skin elsewhere. The differential diagnosis of all of these lesions often depends upon the distribution and arrangement of the skin lesions. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595163 Tue, 01 Mar 2011 00:00:00 +0100 4595163 http://www.medworm.com/index.php?rid=4595162&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001598%2Fabstract%3Frss%3Dyes Abstract: Perioral dermatitis is a relatively common inflammatory disorder of facial skin, often appearing in patients with rosacea, but with less inflammation. A typical perioral dermatitis presentation occurs with the eruption of papules and pustules confined to the nasolabial folds and the skin of the chin. Clinically, small pink papules and pustules may recur over weeks to months, sometimes with fine scales. The differential diagnosis includes seborrheic dermatitis, systemic lupus erythematosus, acne vulgaris, lupus miliaris disseminatus faciei, steroid-induced rosacea, and even basal cell carcinoma. The histopathology is similar to that found in rosacea. With advancement of the process, a perivascular and perifollicular lymphohistiocytic infiltrate develops. Sebaceous hyperplasia may ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595162 Tue, 01 Mar 2011 00:00:00 +0100 4595162 http://www.medworm.com/index.php?rid=4595161&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001586%2Fabstract%3Frss%3Dyes Abstract: Periorbital lesions are dermatologic manifestations affecting the area around the eyes, excluding the eyelids. They can be classified according to their nature and morphology. Although types of skin disorders affect the periorbital area, only those with a prevalent or prominent location will be mentioned, and clinical descriptions will be confined to the rarer entities. Inflammatory lesions include erythematous and erythematous scaling, eczematous and urticarial lesions, vesicular and bullous lesions, and granulomatous lesions. Purpuras, infections, and infestations may be present as well. Benign and malignant tumors are common. Metabolic disorders include some rare entities, such as mucinosis and amyloidosis, but also commoner manifestations such as xanthelasma. Histiocytosis is... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595161 Tue, 01 Mar 2011 00:00:00 +0100 4595161 http://www.medworm.com/index.php?rid=4595160&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000472%2Fabstract%3Frss%3Dyes Abstract: Common shapes encountered in dermatologic diseases include linear, nummular, annular, polycyclic, and arciform. The last three have a relatively restricted differential, which must be entirely explored. It is not uncommon for a single disease to present in annular, arciform or polycyclic configurations; moreover, the lesions may evolve from being arciform to annular and then become polycyclic. Regardless, recognizing the arrangement of the defect will undoubtedly help in making a diagnosis and guiding subsequent management. We explore diseases that often present in annular, arciform, and/or polycyclic forms. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595160 Tue, 01 Mar 2011 00:00:00 +0100 4595160 http://www.medworm.com/index.php?rid=4595159&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000177X%2Fabstract%3Frss%3Dyes Abstract: Acral, referring to the peripheral parts of the body, includes arms and hands, legs and feet, and nails, plus the ears and nose. This contribution, in dealing with the advances in diagnosis of common acrally distributed dermatologic lesions, covers the distribution, localization, shape, and patterns of such lesions. Knowing the morphology of skin lesions is an art that requires not only good observation but also a reasonable classification. For this reason, I have established the “Oumeish classification” to include (1) genodermatoses, (2) physically induced dermatoses, (3) temperature-induced dermatoses, (4) viral disease, (5) vascular entities, (6) neoplasms, and (7) miscellaneous conditions. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595159 Tue, 01 Mar 2011 00:00:00 +0100 4595159 http://www.medworm.com/index.php?rid=4595158&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001574%2Fabstract%3Frss%3Dyes Abstract: Robert Willan (1757-1812), a 1780 graduate in medicine from the University of Edinburgh, spent most of his professional life in London. He worked at the Carey Street Public Dispensary, which was also staffed mainly by such graduates from Edinburgh as Thomas Bateman, Richard Bright, and Thomas Addison. Willan's major dermatology works can be categorized into two groups: an introduction of the first classification of skin diseases, and the correct clinical descriptions of many diseases. Both were based predominantly on morphologic features rather than on the etiologic or pathophysiologic characteristics of a disease. Between 1798 and 1808, Willan published a four-part work, Cutaneous Diseases, in which he developed a classification of skin diseases according to the form of their pa... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595158 Tue, 01 Mar 2011 00:00:00 +0100 4595158 http://www.medworm.com/index.php?rid=4595157&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001781%2Fabstract%3Frss%3Dyes What is hardest of all? That which seems most simple: to see with your eyes what lies in front of your eyes. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595157 Tue, 01 Mar 2011 00:00:00 +0100 4595157 http://www.medworm.com/index.php?rid=4595156&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X11000095%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595156 Tue, 01 Mar 2011 00:00:00 +0100 4595156 http://www.medworm.com/index.php?rid=4595155&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1100006X%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4595155 Tue, 01 Mar 2011 00:00:00 +0100 4595155 http://www.medworm.com/index.php?rid=4254194&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001550%2Fabstract%3Frss%3Dyes The Seventh World Congress of the International Academy of Cosmetic Dermatology (IACD) was held in Cairo, Egypt, where five millennia of history, medicine, and beauty, exemplified by Nephrite as the icon of ageless beauty even to this day, were incorporated into a stellar program (). Mohamed Amer, as Congress President, continued the successful formula of his previous Zagazig Conferences, begun in 1980, with a stellar scientific program, augmented by memorable social events. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254194 Mon, 13 Dec 2010 23:58:52 +0100 4254194 http://www.medworm.com/index.php?rid=4254193&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000805%2Fabstract%3Frss%3Dyes Władysław Kopytowski was a 19th century Polish dermatologist, famous for his early description of the microabscess in psoriasis. He was one of the first Warsaw dermatologists, and was the author of the initial doctoral dissertation in dermatology at Warsaw University. Although he was mostly devoted to morphologic studies of healthy and diseased skin, he also published several interesting clinical reports. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254193 Mon, 13 Dec 2010 23:58:52 +0100 4254193 http://www.medworm.com/index.php?rid=4254192&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001369%2Fabstract%3Frss%3Dyes “Of course you hate medicine,” the voice said. But there was nobody there. I was alone in my office, tired after a long day of patients. I began to panic, thinking that I had become, at best, unglued by fatigue or, at worst, psychotic. Here I was, a successful dermatologist for 20 years, my hand on the telephone, calling a broker to sell my practice. And now I was hearing a voice. It sounded like it was coming from the phone book; but now, in retrospect, I realized it was coming from someplace very deep inside me, a place I had abandoned. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254192 Mon, 13 Dec 2010 23:58:51 +0100 4254192 http://www.medworm.com/index.php?rid=4254191&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000221X%2Fabstract%3Frss%3Dyes The inaugural Edward L. Keyes Resident Contest for Outstanding Case Reports will be awarded for the best case report submitted by a physician in training (resident, fellow, or registrar) for presentation at the 8th World Congress of the International Academy of Cosmetic Dermatology (IACD) in Cancun, Mexico, from January 31 through February 4, 2012. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254191 Mon, 13 Dec 2010 23:58:51 +0100 4254191 http://www.medworm.com/index.php?rid=4254190&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001306%2Fabstract%3Frss%3Dyes Abstract: Terror medicine, which is related to emergency and disaster medicine, focuses on the constellation of medical issues uniquely related to terrorist attacks. It ranges from recognizing features of biologic and chemical agents such as Bacillus anthracis (anthrax) and sarin to the treatment of multi-injury victims of suicide bombings. Medical personnel will be involved in rescue, diagnosis, treatment and recovery from a terrorist attack. Dermatologists could play a central role in diagnosis and treatment in the event of a biologic or chemical attack. The more that individuals and institutions become familiar with the issues concerning terror medicine, the greater the protection they can provide themselves and others. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254190 Mon, 13 Dec 2010 23:58:50 +0100 4254190 http://www.medworm.com/index.php?rid=4254189&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002476%2Fabstract%3Frss%3Dyes The second edition of Surgery of the Skin: Procedural Dermatology is a comprehensive textbook, presenting state of the art medical and cosmetic surgical procedures (). As in the first edition, which has become known as the Handbook, this second edition also captures “the author's hands” performing procedures. The photographs are accompanied by a DVD, which encompasses the ephemeral movement of the surgeon's hand, thereby bringing the reader as close to real-time as possible. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254189 Mon, 13 Dec 2010 23:58:50 +0100 4254189 http://www.medworm.com/index.php?rid=4254188&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001276%2Fabstract%3Frss%3Dyes Abstract: Geriatric dermatology in India is gaining steady momentum, because the aging population is dramatically increasing. India crossed the United Nations definition of an aging country when the population of persons aged older than 60 years exceeded 7%. The dermatologic issues of this aging population are strongly influenced by many social, economic, and cultural factors. Pigmentary disorders are the prime example of cultural factors affecting dermatoses and their treatment. Photoaging differs from what one sees in Western populations due to the inherently dark skin of Indians. Cosmetic dermatology is becoming very popular in the middle and upper classes, and therefore, the aging face has suddenly become an attraction for cosmetic dermatologists. Cutaneous cancers, however, are unusua... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254188 Mon, 13 Dec 2010 23:58:50 +0100 4254188 http://www.medworm.com/index.php?rid=4254187&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001264%2Fabstract%3Frss%3Dyes Abstract: Malignant mesenchymal neoplasms of skin and soft tissues are characterized by an extreme clinicopathologic heterogeneity. Although all sarcomas of deep soft tissues may also arise in superficial locations, there are important clinicopathologic differences. Lipogenic sarcomas represent the most frequent type of sarcomas in deep soft tissues, but purely dermal liposarcomas are exceedingly rare. Vascular and fibroblastic or myofibroblastic sarcomas, however, are much more frequent in dermal location. In contrast with most deep-seated sarcomas, morphologic grading of dermal sarcomas has only a limited importance because most types of dermal sarcoma have a rather favorable clinical prognosis. Important exceptions to this rule are epithelioid sarcoma and cutaneous angiosarcoma, which a... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254187 Mon, 13 Dec 2010 23:58:49 +0100 4254187 http://www.medworm.com/index.php?rid=4254186&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001252%2Fabstract%3Frss%3Dyes Abstract: Autoimmune blistering diseases are a significant cause of morbidity and mortality in the elderly population. Given the advancing age of the population, the incidence of these disorders, particularly bullous pemphigoid, is expected to rise. This contribution reviews autoimmune immunobullous disorders of particular relevance in the elderly population. These include bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, pemphigus, paraneoplastic pemphigus, and linear immunoglobulin A bullous dermatosis. Because therapy and management of individual immunobullous dermatoses differ, establishing the diagnosis is often critically important. An overall approach to bullous diseases in the elderly, as well as key clinical features, appropriate diagnostic tests, micros... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254186 Mon, 13 Dec 2010 23:58:49 +0100 4254186 http://www.medworm.com/index.php?rid=4254185&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001240%2Fabstract%3Frss%3Dyes Abstract: Rosacea is a chronic inflammatory disease with a predominance of facial manifestations. The prevalence is increasing with age, peaking in the group aged older than 65 years. In 1997, one in eight Americans was aged 65 years and older. By 2030, more than 70 million individuals will be in this age group. This contribution reviews the current understanding of pathogenesis, aggravating factors, classification, comorbidities, and treatment options. Rosacea is a manageable disease that negatively affects quality of life. Rosacea increases the risk of depression and shows a significant proportion of extracutaneous manifestations, in particular ocular rosacea. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254185 Mon, 13 Dec 2010 23:58:49 +0100 4254185 http://www.medworm.com/index.php?rid=4254184&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001239%2Fabstract%3Frss%3Dyes Abstract: Treating elderly patients has become common in daily clinical practice. Consequently, it is important to focus our interest on a neglected region: the nail area. Anatomy and physiology are indispensable for a good comprehension of some phenomenons. Histopathology of senile changes may explain some pathologic situations and is indispensable for diagnosing uncommon tumors. Chemical composition shows that a normal nail contains 18% water. The rate of linear nail decreases as age advances. Ridging is a normal finding on fingernails, with color varying from shades of yellow to grey. The most common disorders, however, are linked to repeated trauma, with sometimes ingrowing toenails with different appearances. Tumors in the nail area are relatively frequent. Nail fungal infection may b... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254184 Mon, 13 Dec 2010 23:58:49 +0100 4254184 http://www.medworm.com/index.php?rid=4254183&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001227%2Fabstract%3Frss%3Dyes Abstract: Senescent alopecia was originally thought to affect people aged 50 years or older with no family history or evidence of pattern balding. It was described as a diffuse thinning involving the whole scalp due to a steady decrease in thick terminal hairs, but without evidence of increased miniaturization. Senescent alopecia is not a primary diagnosis in this clinic. Most possible examples of it are assumed to be androgenetic or diffuse alopecia. In the study reported here, horizontal sections of 2149 scalp specimens from individuals with male and female pattern and diffuse alopecia, as well as from normal controls, were examined, and their follicular counts were recorded and sorted into decades. The decade of 20 to 29 years contained a significant number of patients and was used for ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254183 Mon, 13 Dec 2010 23:58:48 +0100 4254183 http://www.medworm.com/index.php?rid=4254182&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001215%2Fabstract%3Frss%3Dyes Abstract: Because the older group of the population is becoming more numerous, we see a high prevalence in drug adverse reactions among the elderly. Polypharmacy, which is the use of five or more medications, is one reason why this group has a greater risk of adverse drug reactions. Cutaneous adverse reactions to drugs are not always life threatening, but they can be an important factor for a poor quality of life among older patients. The potential benefits of appropriately prescribed medications are unquestionable, but the possibility of an adverse reaction must be recognized and prevented in older people so they can have a better quality of life. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254182 Mon, 13 Dec 2010 23:58:48 +0100 4254182 http://www.medworm.com/index.php?rid=4254181&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001203%2Fabstract%3Frss%3Dyes Abstract: Dry skin, or xerosis, is a common skin condition in older adults, but it is not a normal part of aging. The geriatric patient may have several incurable, but treatable, chronic diseases that affect their skin. Xerosis in older adults is multifactorial: intrinsic changes in keratinization and lipid content, use of diuretics and similar medications, and overuse of heaters or air conditioners all contribute. Xerosis causes pruritus, which then leads to excoriations and risk of skin infections. Patients can minimize the effect of xerosis by increasing the ambient humidity, modifying their bathing technique and products, and using emollients to replace the lipid components of the skin. Care should be made to avoid skin sensitizers, such as lanolin, aloe vera, and parabens, that are co... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254181 Mon, 13 Dec 2010 23:58:48 +0100 4254181 http://www.medworm.com/index.php?rid=4254180&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001197%2Fabstract%3Frss%3Dyes Abstract: Dry skin is characterized by a decreased lipid content and a delayed reconstitution of the epidermal barrier after skin irritation. These are problems of high relevance in the aged population, especially in the development of irritant contact dermatitis. Asteatotic and perineal irritant dermatitis are the most important subtypes of irritant contact dermatitis in the elderly. This contribution presents a compressed survey on these subtypes and elucidates their relation to an impaired barrier function. Typical irritants affecting aged individuals are explained and compared with irritants that seem to be more significant in younger people. Results of biophysical investigations, such as measurement of transepidermal water loss, are discussed regarding their age-dependence. Transepide... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254180 Mon, 13 Dec 2010 23:58:47 +0100 4254180 http://www.medworm.com/index.php?rid=4254179&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001185%2Fabstract%3Frss%3Dyes Abstract: Contact dermatitis from irritant and allergic sources is the reason for 6% to 10% of all dermatologic visits with considerable morbidity and economic impact. Allergic contact dermatitis is a T-cell–mediated inflammatory reaction and develops in predisposed individuals as a consequence of environmental exposure to allergens. Aging is correlated with the rate and type of contact sensitization because of “immunosenescence.” The number of old people is growing around the world. This contribution reviews the main findings from published epidemiologic studies on contact allergy in elderly populations. In all examined studies, patch testing was performed in patients with cutaneous manifestations possibly related to contact dermatitis; the prevalence of contact dermatitis in the el... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254179 Mon, 13 Dec 2010 23:58:47 +0100 4254179 http://www.medworm.com/index.php?rid=4254178&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001173%2Fabstract%3Frss%3Dyes Abstract: Pruritus is an unpleasant sensation leading to the desire to scratch. It is the most common symptom in dermatology, and various skin and systemic diseases can be associated with the presence of itching. Pruritus may also be provoked by numerous drugs. Although the exact epidemiologic data are still absent, it is generally accepted that elderly people frequently suffer from pruritus, and the problem of itching in this population remains a challenge for clinicians. The elderly often complain of numerous comorbidities that complicate the determination of the cause of pruritus, as well as its treatment. Physical and mental deprivation may complicate proper assessment of pruritus severity and negatively impair compliance with complex antipruritic therapies. Taking also into account he... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254178 Mon, 13 Dec 2010 23:58:46 +0100 4254178 http://www.medworm.com/index.php?rid=4254177&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001161%2Fabstract%3Frss%3Dyes Abstract: This contribution will address the effect of aging on skin functions, with a particular focus on skin permeability, wound healing, angiogenesis, lipogenesis, sweat production, immune function, and vitamin D synthesis. With accelerating age, skin functions deteriorate due to structural and morphologic changes. Skin is prone to the development of several diseases, varying from benign to malignant. Because the number of persons aged 80 and older is expected to rise in the next decades, disease prevention will become an important issue. Screening examinations and prevention through public education starting at an early age regarding sun avoidance, the use of sunscreens and the importance of a balanced nutrition are the first steps for successful healthy aging. Although the fundamenta... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254177 Mon, 13 Dec 2010 23:58:46 +0100 4254177 http://www.medworm.com/index.php?rid=4254176&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001288%2Fabstract%3Frss%3Dyes What constitutes being older? Is it chronologic age or is it general well being? Even the names used for discussing geriatric dermatology offer no answer: chronologically challenged, senior citizen, pensioner, elderly person, retiree, or just plain old. Are the “golden years" becoming less than “golden?" (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254176 Mon, 13 Dec 2010 23:58:46 +0100 4254176 http://www.medworm.com/index.php?rid=4254175&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002294%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254175 Mon, 13 Dec 2010 23:58:46 +0100 4254175 http://www.medworm.com/index.php?rid=4254174&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10002257%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4254174 Mon, 13 Dec 2010 23:58:46 +0100 4254174 http://www.medworm.com/index.php?rid=4110113&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000696%2Fabstract%3Frss%3Dyes Fryderyk Goldschlag (1893-1973) was a professor of dermatology who conducted his medical career in Lwów, Poland, and Sydney, Australia. He dealt with the most interesting dermatology problems of his time and published most his papers in international dermatology journals. He was the chairman of the Lwów Section of the Polish Dermatology Society and was later a founding member of the Australian Dermatology Society. In addition, he had an exceptionally broad knowledge and interest in literature and art. He developed an important collection of Polish and Jewish paintings, many of which he donated to the National Museum in Cracow. After retirement, he became an active member of the Polish community in London and a prolific journal writer. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110113 Fri, 29 Oct 2010 17:36:08 +0100 4110113 http://www.medworm.com/index.php?rid=4110112&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X09001400%2Fabstract%3Frss%3Dyes If we associate medicine with the Holocaust at all, the name Mengele will probably come to mind. Josef Mengele, an MD and PhD, was known as the “angel of death of Auschwitz,” the Nazi's main extermination camp where more than 2 million Jews were gassed and cremated. Many assume that Mengele's participation in the Holocaust was a medical aberration and that he was an isolated medical madman. This assumption is a mistake, however, because the medical profession played a central role in planning and implementing the genocidal murder of more than 6 million Jews. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110112 Fri, 29 Oct 2010 17:36:08 +0100 4110112 http://www.medworm.com/index.php?rid=4110111&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001537%2Fabstract%3Frss%3Dyes In their recent exhaustive and excellent review of the potential harmful effects of nutritional supplements, Driscoll et al discussed studies of zinc supplementation and skin cancer risk. In particular, they reviewed the Supplementation en Vitamines et Minéraux Antioxydants (SUVIMAX) and Vitamins and Lifestyle (VITAL) studies. The first of these studies (SUVIMAX) was a randomized placebo-controlled study that reported an elevated risk of skin cancers in women—but not men—taking a cocktail of antioxidants (ascorbic acid, α-tocopherol, β-carotene, zinc, and selenium). The second (VITAL) was a nonrandomized naturalistic study in which individuals taking these same antioxidants by choice were compared with people who chose not to take such nutritional supplements. (Source: Clinics in De... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110111 Fri, 29 Oct 2010 17:36:08 +0100 4110111 http://www.medworm.com/index.php?rid=4110110&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000556%2Fabstract%3Frss%3Dyes Abstract: Veterinarians are confronted with a variety of food and nutrition-related skin diseases, with cutaneous food adverse reaction the most common in small animal dermatology. In addition to canine atopic dermatitis, cutaneous food adverse reaction has been an area of interest for extensive research for the last decade. Nutritional deficiencies and toxicoses are rare these days due to commercially available high-quality diets; however, poorly stored diets, inadequate husbandry of exotic pets, or problems in a farm animal environment may result in zinc, vitamin A, vitamin C, and fatty acid, or copper deficiency. Inherited deficiencies due to abnormal zinc absorption through the gastrointestinal tract must be considered in Nordic breed dogs and goats. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110110 Fri, 29 Oct 2010 17:36:07 +0100 4110110 http://www.medworm.com/index.php?rid=4110109&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000532%2Fabstract%3Frss%3Dyes Abstract: Normal functioning of the human body requires a balance between nutritional intake and metabolism, and imbalances manifest as nutritional deficiencies or excess. Nutritional deficiency states are associated with social factors (war, poverty, famine, and food fads), medical illnesses with malabsorption (such as Crohn disease, cystic fibrosis, and after bariatric surgery), psychiatric illnesses (eating disorders, autism, alcoholism), and medications. Nutritional excess states result from inadvertent or intentional excessive intake. Cutaneous manifestations of nutritional imbalance can herald other systemic manifestations. This contribution discusses nutritional deficiency and excess syndromes with cutaneous manifestations of particular interest to clinical dermatologists. (Source: ... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110109 Fri, 29 Oct 2010 17:36:07 +0100 4110109 http://www.medworm.com/index.php?rid=4110108&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000544%2Fabstract%3Frss%3Dyes Abstract: Vitamin D is a fat-soluble nutrient that humans obtain through the diet and by synthesis in the skin upon exposure to ultraviolet B. Vitamin D is then converted by the liver to 25-hydroxyvitamin D, its major circulating form. This form is the best indicator of vitamin D nutritional status and is easily measured. Under the influence of parathyroid hormone, the kidney then converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D, the biologically active, hormonal form of the nutrient that is important in the metabolism of calcium and phosphorus and is critical in building and maintaining healthy bones. Many cell types outside of the skeletal system, including various cells in the skin, also express the vitamin D receptor. In addition, many cell types convert circulating 25-hydroxyvi... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110108 Fri, 29 Oct 2010 17:36:07 +0100 4110108 http://www.medworm.com/index.php?rid=4110107&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000057X%2Fabstract%3Frss%3Dyes Abstract: The incidence of nonmelanoma skin cancer is increasing every year. Basal cell carcinoma and squamous cell carcinoma are the two major types of nonmelanoma skin cancer. Among other factors, understanding the potential role of nutrients in the development, progression, and treatment of nonmelanoma skin cancer is critical. This contribution provides a review of the nutrients that have been more extensively investigated in the literature with regard to nonmelanoma skin cancer, including dietary fats, retinol, carotenoids, vitamin C, vitamin D, vitamin E, selenium, copper, iron, zinc, green tea, and black tea. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110107 Fri, 29 Oct 2010 17:36:07 +0100 4110107 http://www.medworm.com/index.php?rid=4110106&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000507%2Fabstract%3Frss%3Dyes Abstract: Melanoma has continued to rise in incidence despite public efforts to promote sun protection behaviors. Because sunscreen use does not completely prevent skin cancer induced by ultraviolet radiation, additional chemopreventive methods for protecting against and reversing the effects of ultraviolet photodamage need evaluation. Recent years have brought increased interest in dietary factors, such as natural botanicals and vitamins, for the prevention of melanoma. This contribution provides a narrative review of the relevant, nutrition-related literature found by searching the keywords “melanoma chemoprevention,” “nutrition and melanoma,” “dietary botanicals and melanoma prevention,” “green tea and melanoma,” “vitamin D and melanoma,” and “vitamin E and melanom... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110106 Fri, 29 Oct 2010 17:36:07 +0100 4110106 http://www.medworm.com/index.php?rid=4110105&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000060X%2Fabstract%3Frss%3Dyes Abstract: Autoimmune and nonautoimmune bullous diseases can both be associated with significant morbidity and mortality. Although our understanding of the pathogenic mechanisms of these diseases has increased tremendously, there is still much to learn about the various factors affecting their onset, course, and therapy. In recent years, increasing information has been published about the effect of vitamins, minerals, and other nutrients on bullous skin diseases. Some factors are believed to be inducers (thiol and phenol-containing foods in pemphigus), whereas others are believed to be protective (antioxidants in cutaneous porphyrias). This contribution reviews the evidence in the literature of the role of various dietary factors in bullous diseases, including the nonautoimmune and the defi... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110105 Fri, 29 Oct 2010 17:36:07 +0100 4110105 http://www.medworm.com/index.php?rid=4110104&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000519%2Fabstract%3Frss%3Dyes Abstract: Nutritional supplementation may provide a viable treatment alternative in patients with psoriasis. Randomized, controlled trials have shown the effectiveness of topical vitamin A and D derivatives, intravenous ω-3 fatty acids, oral inositol, and various combined therapies. Dual therapies of ultraviolet B phototherapy and fish oil, retinoids and thiazolidinediones, and cyclosporine and a low-calorie diet were effective in the treatment of psoriasis in randomized, controlled trials. This contribution also reviews the potential negative effect of alcohol and the potential positive effects of vitamin B12, selenium, retinoic acid metabolism-blocking agents, and a gluten-free diet in the treatment of psoriasis. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110104 Fri, 29 Oct 2010 17:36:07 +0100 4110104 http://www.medworm.com/index.php?rid=4110103&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000568%2Fabstract%3Frss%3Dyes Abstract: Atopic dermatitis, a chronic disease with no cure, currently affects almost one-fifth of the population of industrialized nations. Treatment can be challenging for physicians and patients alike. Children are commonly affected, making it even more difficult to find safe therapeutic options, especially in severe disease. Interest in diet and nutrition has increased during the last few years. Nutritional interventions are both intriguing and accessible for many patients. Given the recent expansion of the field of nutrition in the realm of medicine and in popular culture, it is important for the dermatologist to be knowledgeable about the risks and benefits of nutritional interventions. This contribution reviews the current literature on the role of nutrition in atopic dermatitis, fr... Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110103 Fri, 29 Oct 2010 17:36:07 +0100 4110103 http://www.medworm.com/index.php?rid=4110102&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000416%2Fabstract%3Frss%3Dyes Abstract: There are significant data supporting the role of diet in acne. Our Western diet includes many dairy sources containing hormones.. The natural function of milk being to stimulate growth, it contains anabolic steroids as well as true growth hormones and other growth factors. The presence of 5α-pregnanedione, 5α-androstanedione, and other precursors of 5α-dihydrotestosterone add to the potency of milk as a stimulant of acne. In addition, foods with significant sugar content and other carbohydrates yielding high glycemic loads affect serum insulin and insulin-like growth factor-1 levels, both of which promote increased production of available androgens and the subsequent development of acne. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110102 Fri, 29 Oct 2010 17:36:07 +0100 4110102 http://www.medworm.com/index.php?rid=4110101&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000593%2Fabstract%3Frss%3Dyes The role of our diet and what we eat defines us and our patients on many levels. In some respects, our diet identifies our approach to life and our ethnicity, or religion, or both. “I am kosher,” “I am a vegetarian,” “I am a vegan,” I am Italian and eat lots of pasta,” “I am an American and love hot dogs and hamburgers,” “I do not eat fish on Friday,” “I am fasting today.” The list of exemplary phrases can go on and on to demonstrate how what we eat reflects who we are. The way we eat and what we eat defines us and often reflects our values and our approach to life. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110101 Fri, 29 Oct 2010 17:36:07 +0100 4110101 http://www.medworm.com/index.php?rid=4110100&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10001835%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110100 Fri, 29 Oct 2010 17:36:07 +0100 4110100 http://www.medworm.com/index.php?rid=4110099&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X1000180X%2Fabstract%3Frss%3Dyes (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=4110099 Fri, 29 Oct 2010 17:36:07 +0100 4110099 http://www.medworm.com/index.php?rid=3908932&cid=s_35413_12_f&fid=35413&url=http%3A%2F%2Fwww.cidjournal.com%2Farticle%2FPIIS0738081X10000131%2Fabstract%3Frss%3Dyes George Clinton Andrews, Jr was born on November 26, 1891 in Tarrytown, New York, into a family with a historic connection to the region and the country. This pedigree was one he wholeheartedly embraced and endeavored to have others appreciate throughout his life. He was a direct descendant of George Clinton, Brigadier General of the American Revolutionary Army, first Governor of New York, and former Vice President of the United States under Jefferson and Madison. In fact, Andrews was known to begin his daily routine with a cup of tea and an English muffin while sitting at the Clinton campaign table from the Revolutionary War. (Source: Clinics in Dermatology) Clinics in Dermatology journals http://www.medworm.com/rss/comments.php?id=3908932 Sat, 28 Aug 2010 05:43:05 +0100 3908932