MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Comparative Hepatology' source. Fri, 20 Jan 2012 16:22:20 +0100 http://www.medworm.com/index.php?rid=5432319&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F11 Conclusions: Mechanistic insights revealed that pro-survival pathways such as Akt, ERK1/2, and NFkB signaling were upregulated in the ILK KO mice. Inhibition of only NFkB and ERK1/2 signaling led to an increase in the susceptibility of ILK KO hepatocytes to Jo-2-induced apoptosis. These studies suggest that ILK elimination from hepatocytes protects against Jo-2 induced apoptosis by upregulating survival pathways. FAK decrease may also play a role in this process. The results presented show that the signaling effects of ILK related to these functions are mediated in part mediated through NFkB and ERK1/2 signaling. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5432319 Mon, 21 Nov 2011 05:00:00 +0100 5432319 http://www.medworm.com/index.php?rid=5409353&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F10 Conclusion: These findings suggest a potential role for liver fatty acid binding protein and NADPH oxidase in the development of non alcoholic steatohepatitis. Furthermore, cocoa supplementation may have be of therapeutic benefit in less sever forms of NASH. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5409353 Mon, 14 Nov 2011 05:00:00 +0100 5409353 http://www.medworm.com/index.php?rid=5209866&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F9 Autoimmune liver diseases (AILDs) are common leading causes for liver cirrhosis and terminal stage of liver disease. They have variable prevalence among patients with liver disease and have two major clinical and biochemical presentations. Autoimmune hepatitis (AIH) is the typical example of hepatocellular AILD, but it can also be presented under a cholestatic pattern. AIH has a scoring diagnostic system and respond in most cases to the treatment with prednisolone and azathioprine. Primary biliary cirrhosis (PBC) is the second most common AILD, with a cholestatic presentation and characterized by positive antimitochondrial antibody (AMA). It has an excellent response and long term outcome with the administration of ursodeoxycholic acid (UDCA). Another AILD that is thought to be a variant o... Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5209866 Mon, 12 Sep 2011 04:00:00 +0100 5209866 http://www.medworm.com/index.php?rid=5110452&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F7 ${item.shortDescription} (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5110452 Sun, 07 Aug 2011 23:00:00 +0100 5110452 http://www.medworm.com/index.php?rid=5098523&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F5 ${item.shortDescription} (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5098523 Tue, 02 Aug 2011 23:00:00 +0100 5098523 http://www.medworm.com/index.php?rid=5098522&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F6 ${item.shortDescription} (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5098522 Tue, 02 Aug 2011 23:00:00 +0100 5098522 http://www.medworm.com/index.php?rid=5053551&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F4 ${item.shortDescription} (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5053551 Fri, 22 Jul 2011 23:00:00 +0100 5053551 http://www.medworm.com/index.php?rid=5040649&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F3 Background: Ischemic pre- and postconditioning protects the liver against ischemia/reperfusion injuries. The aim of the present study was to examine how ischemic pre- and postconditioning affects gene expression of hypoxia inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor A (VEGF-A) and transforming growth factor beta (TGF-beta) in liver tissue. Methods: 28 rats were randomized into five groups: control; ischemia/reperfusion; ischemic preconditioning (IPC); ischemic postconditioning (IPO); combined IPC and IPO. IPC consisted of 10 min of ischemia and 10 min of reperfusion. IPO consisted of three cycles of 30 sec. reperfusion and 30 sec. of ischemia. Results: HIF-1alpha mRNA expression was significantly increased after liver ischemia compared to controls (p=0.010). HI... Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5040649 Mon, 18 Jul 2011 23:00:00 +0100 5040649 http://www.medworm.com/index.php?rid=5021601&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F2 Conclusions: Kupffer cells of the developing mouse liver appear quite similar to those of other mammalian species, confirming that the mouse presents a useful animal model for studies of liver macrophage developmental structure and function. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=5021601 Mon, 11 Jul 2011 23:00:00 +0100 5021601 http://www.medworm.com/index.php?rid=4999812&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F10%2F1%2F1 Conclusions: In an animal model of sleep apnoea, intermittent hypoxia causes liver damage due to oxidative stress after 35 days, but not after 21 days. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=4999812 Mon, 04 Jul 2011 23:00:00 +0100 4999812 http://www.medworm.com/index.php?rid=4062561&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F8 Conclusions: Our results point to an important role of all types of sinusoidal cells in regeneration from CDE induced liver damage and call for utmost caution in using traditional marker for identifying specific cell types. Thus, M2-pyruvate kinase should no longer be used for estimating the oval cell response in mouse liver. CDE diet leads to activation of GFAP positive HSCs in the pericentral zone of liver lobulus. In the periportal zone the detection of GFAP in biliary cells and oval cells, calls other cell types as progenitors of hepatocytes into question under CDE diet conditions. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=4062561 Tue, 12 Oct 2010 23:00:00 +0100 4062561 http://www.medworm.com/index.php?rid=3886916&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F7 Conclusions: These results suggest that the T cells from HCV immunized mice recognize the HCV proteins in the liver of the transgenic mouse model and homed to the HCV antigen expression sites. We propose using this model system to study active T cell responses in HCV infection. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=3886916 Thu, 19 Aug 2010 23:00:00 +0100 3886916 http://www.medworm.com/index.php?rid=3722798&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F6 Conclusions: The finding of a significant association of ABCB4 1583_1584G with gallbladder mucoceles in dogs suggests that this phospholipid flippase may play a role in the pathophysiology of this disorder. Affected dogs may provide a useful model for identifying novel treatment strategies for ABCB4-associated hepatobiliary disease in people. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=3722798 Fri, 02 Jul 2010 23:00:00 +0100 3722798 http://www.medworm.com/index.php?rid=3296019&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F5 Conclusions: Our results demonstrate that FEO expression is associated with modified liver handling of glycogen and triacylglycerides accompanied by morphometric and ultrastructural adaptations in the hepatocytes. Because the cellular changes detected in the liver cannot be attributed to a simple alternation between feeding and fasting conditions, they also strengthen the notion that RFS promotes a rheostatic adjustment in liver physiology during FEO expression. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=3296019 Tue, 23 Feb 2010 00:00:00 +0100 3296019 http://www.medworm.com/index.php?rid=3285417&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F4 Conclusions: K19 positive hepatocellular neoplasias are highly comparable to man and occur in 12% of canine hepatocellular tumours and are associated with a poorly differentiated histology and aggressive tumour behaviour. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=3285417 Thu, 18 Feb 2010 00:00:00 +0100 3285417 http://www.medworm.com/index.php?rid=3218310&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F3 Conclusions: C. trachomatis can efficiently propagate in hepatocytes affecting transcription rate of some liver-specific genes. Ongoing cholesterol synthesis is essential for chlamydial growth in hepatocytes. Inhibitors of cholesterol biosynthesis can supplement conventional strategy in the management of C. trachomatis infection. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=3218310 Thu, 28 Jan 2010 00:00:00 +0100 3218310 http://www.medworm.com/index.php?rid=3187002&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F2 Conclusions: An isolated increase in sinusoidal flow does not have the same genetic, microscopic or macroscopic impact on the liver as that seen in the liver remnant after partial hepatectomy, indicating that increased sinusoidal flow may not be a sufficient stimulus in itself for the initiation of liver regeneration. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=3187002 Wed, 20 Jan 2010 00:00:00 +0100 3187002 http://www.medworm.com/index.php?rid=3140173&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F9%2F1%2F1 Conclusions: Serum TNFR-II, IL-2Ralpha and IL-8, may be used as combined markers in HCV-infected cases for patients at high risk of developing HCC; further studies, however, are mandatory to check these findings before their application at the population level. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=3140173 Tue, 05 Jan 2010 00:00:00 +0100 3140173 http://www.medworm.com/index.php?rid=2599665&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F8%2F1%2F5 Conclusions: As in adult liver, there is a phenotypic heterogeneity of the mesenchymal cells during fetal liver development. During portal tract maturation, myofibroblastic cells disappear in normal development but persist in fibrosis following ductal plate malformation. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=2599665 Mon, 13 Jul 2009 23:00:00 +0100 2599665 http://www.medworm.com/index.php?rid=2595941&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F8%2F1%2F4 Background: It has been postulated that ethanol affects hepatic sinusoidal and perisinusoidal cells. In the current experimental study, we investigated the early effect of a single intravenous dose of ethanol on the diameter of liver sinusoidal endothelial fenestrae in New Zealand White rabbits. The diameter of fenestrae in these rabbits is similar to the diameter found in humans with healthy livers. The effect of ethanol on the size of fenestrae was studied using transmission electron microscopy, because plastic embedding provides true measures for the diameter of fenestrae. Results: After intravenous administration of a single dose of 0.75 g/kg, ethanol concentration peaked at 1.1 +/- 0.10 g/l at ten minutes after injection. Compared to control rabbits (103 +/- 1.1 nm; n=8), the average ... Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=2595941 Sun, 12 Jul 2009 23:00:00 +0100 2595941 http://www.medworm.com/index.php?rid=2578245&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F8%2F1%2F3 Conclusions: At least two biopsies (RNAlater and formalin) are needed. Since human and canine liver diseases are highly comparable, it is conceivable that the protocols described here can be easily translated into the human biomedical field. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=2578245 Tue, 07 Jul 2009 23:00:00 +0100 2578245 http://www.medworm.com/index.php?rid=2434390&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F8%2F1%2F2 Conclusions: The data indicate that despite extended anorexia, differences in metabolic fuel privation, and bouts of reduced body temperatures, hibernators normally do not experience broad changes in hepatobiliary function. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=2434390 Tue, 26 May 2009 04:00:00 +0100 2434390 http://www.medworm.com/index.php?rid=2407841&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F8%2F1%2F1 Conclusions: LAGS ligands inhibit HSC trans-differentiation and proliferation in vitro but show little efficacy in inhibiting liver fibrosis, in vivo. The reason(s) for this disparity is/are likely associated with an altered myofibroblast phenotype, in vitro, with expression of rPGMRC1 in vitro but not in vivo. These data emphasize the limitations of in vitro-derived myofibroblasts for predicting their activity in vivo, in studies of fibrogenesis. The data also demonstrate that the anti-fibrogenic effects of PCN in vivo are likely mediated entirely via the PXR. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=2407841 Mon, 11 May 2009 04:00:00 +0100 2407841 http://www.medworm.com/index.php?rid=1913438&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F8 Conclusion: Our results indicate that PLCbeta4 gene and protein expression is regulated by a circadian clock in the mouse liver and is not dependent on the external photoperiod. A light-independent daily translocation of PLCbeta4 implies that it may play a key role in nuclear signaling in hepatocytes and serve as a daily temporal cue for physiological processes in the liver. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1913438 Tue, 28 Oct 2008 04:00:00 +0100 1913438 http://www.medworm.com/index.php?rid=1854921&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F7 Background: A novel transparent stock of medaka (Oryzias latipes; STII), recessive for all pigments found in chromatophores, permits transcutaneous imaging of internal organs and tissues in living individuals. Findings presented describe the development of methodologies for non invasive in vivo investigation in STII medaka, and the successful application of these methodologies to in vivo study of hepatobiliary structure, function, and xenobiotic response, in both 2 and 3 dimensions. Results: Using brightfield, and widefield and confocal fluorescence microscopy, coupled with the in vivo application of fluorescent probes, structural and functional features of the hepatobiliary system, and xenobiotic induced toxicity, were imaged at the cellular level, with high resolution ( (Source: Comparat... Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1854921 Mon, 06 Oct 2008 04:00:00 +0100 1854921 http://www.medworm.com/index.php?rid=1703679&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F6 Conclusions: ALT-LDH index was useful to predict the prognosis of the patients with acute liver injury and should be helpful to begin preparation for LT soon after admission. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1703679 Thu, 14 Aug 2008 04:00:00 +0100 1703679 http://www.medworm.com/index.php?rid=1435402&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F5 Conclusions: Lipogranulomas are not a contributing factor in hepatic fibrosis, but might be a potential indicator of the accumulation of iron and lipid inside the liver. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1435402 Mon, 12 May 2008 04:00:00 +0100 1435402 http://www.medworm.com/index.php?rid=1420030&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F4 Conclusions: Viability, structure and many of the essential functional characteristics of isolated LSECs are clearly better preserved when the cultures are maintained under more physiologic oxygen levels. Endogenous production of hydrogen peroxide is to a large extent responsible for the toxic effects observed in high oxygen environments. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1420030 Mon, 05 May 2008 04:00:00 +0100 1420030 http://www.medworm.com/index.php?rid=1296799&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F3 Conclusion: This case illustrates that rtM204V/I, rtA181V, and rtN236T resistance mutations can coexist in a patient but do not preclude the recycling of lamivudine and adefovir in combination therapy, when no other therapeutic choices are available. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1296799 Wed, 12 Mar 2008 04:00:00 +0100 1296799 http://www.medworm.com/index.php?rid=1267241&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F2 Conclusions: The findings confirm that in FNH there is a portal tract injury leading to local portal vein injury. This leads to a cascade of events, including arterial venous shunts, ductular reaction, and scar formation. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1267241 Fri, 29 Feb 2008 05:00:00 +0100 1267241 http://www.medworm.com/index.php?rid=1205709&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F7%2F1%2F1 Conclusion: These findings suggest that in rats with a portacaval shunt a systemic reduction of oxidant scavenging ability, correlated with hyperammonemia, is principally produced. It could be hypothesized, therefore, that the reduced antioxidant defences would mediate a systemic inflammation. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=1205709 Tue, 05 Feb 2008 05:00:00 +0100 1205709 http://www.medworm.com/index.php?rid=962253&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F6%2F1%2F9 Conclusion: Our results show that TGF-beta1 in pPK9a-transferred mice liver with ZnSO4 feeding can achieve a high expression level with significant fibrosis. However, since TGF-beta1 induction is transient in our model, the fibrotic level does not reach a large scale (panlobular fibrosis) as seen in the CCl4-treated liver. Our model hence represents a dynamic and reversible liver fibrosis and could be a useful tool for studying early molecular mechanism of fibrogenesis or screening of antifibrotic drugs for clinical use. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=962253 Fri, 19 Oct 2007 04:00:00 +0100 962253 http://www.medworm.com/index.php?rid=767964&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F6%2F1%2F8 Conclusions: In canine hepatitis and cirrhosis the major regenerative downstream pathways were activated. Signaling pathways are similarly activated in human cirrhotic liver samples, irrespective of the differences in etiology in the human samples (alcohol abuse and HCV-infection). Therefore, canine hepatitis and cirrhosis could be an important clinical model to evaluate novel interventions prior to human clinical trials. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=767964 Tue, 31 Jul 2007 04:00:00 +0100 767964 http://www.medworm.com/index.php?rid=766517&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F6%2F1%2F7 Despite intensive studies, the clinical opportunities for patients with fibrosing liver diseases have not improved. This will be changed by increasing knowledge of new pathogenetic mechanisms, which complement the "canonical principle" of fibrogenesis. The latter is based on the activation of hepatic stellate cells and their transdifferentiation to myofibroblasts induced by hepatocellular injury and consecutive inflammatory mediators such as TGF-beta. Stellate cells express a broad spectrum of matrix components. New mechanisms indicate that the heterogeneous pool of (myo-)fibroblasts can be supplemented by epithelial-mesenchymal transition (EMT) from cholangiocytes and potentially also from hepatocytes to fibroblasts, by influx of bone marrow-derived fibrocytes in the damaged liver tissue ... Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=766517 Mon, 30 Jul 2007 04:00:00 +0100 766517 http://www.medworm.com/index.php?rid=708131&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F6%2F1%2F6 Conclusions: Our data demonstrate telomerase activation in liver regeneration by compensatory hyperplasia in a large animal model with telomere biology comparable to humans. Telomerase activation may constitute a mechanism to protect proliferating liver cells against telomere shortening and oxidative stress. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=708131 Mon, 02 Jul 2007 04:00:00 +0100 708131 http://www.medworm.com/index.php?rid=602008&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F6%2F1%2F5 Conclusion: The data provide evidence that beside the TGF-beta-Smad 3 pathway CTGF and PAI-1 expression is additionally dependent on Erk activity in hepatocytes giving new insights into regulation of the profibrogenic proteins. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=602008 Wed, 02 May 2007 04:00:00 +0100 602008 http://www.medworm.com/index.php?rid=602009&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F6%2F1%2F4 Conclusions: The corresponding increase in CIDE-A expression with hyperinsulinemia and liver steatosis suggests a novel pathway for lipid accumulation in the liver. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=602009 Tue, 01 May 2007 04:00:00 +0100 602009 http://www.medworm.com/index.php?rid=447610&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F6%2F1%2F1 Conclusion: The data provide evidence that TGF-β induces NADPH oxidase activity which causes radical production upon the transdifferentiation of activated HSCs to M-HTs. Myofibroblastoid cells are equipped with high levels of superoxide dismutase activity as well as glutathione to counterbalance NADPH oxidase dependent oxidative stress and to avoid cellular damage. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=447610 Tue, 20 Feb 2007 05:00:00 +0100 447610 http://www.medworm.com/index.php?rid=307037&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F9 Conclusions: Livers of ecNOS knockout mice have a decreased sensitivity to endothelin at physiologic concentrations; this is associated with a decreased expression of ETA receptors, but not with other factors, such as iNOS, ETB receptors, adrenomedullin or heme-oxygenase. Further studies targeting adaptive changes in ETA receptor distribution and/or intracellular signaling downstream of the receptor are indicated. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=307037 Tue, 05 Dec 2006 07:00:00 +0100 307037 http://www.medworm.com/index.php?rid=285856&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F8 Conclusions: Rgs16 is one of a subset of genes that is circadian regulated both in SCN and liver. Rgs16 mRNA expression in liver responds rapidly to changes in feeding schedule, coincident with key transcription factors controlling the circadian clock. Rgs16 expression can be used as a marker to identify and investigate novel G-protein mediated metabolic and circadian pathways, in specific zones within the liver. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=285856 Thu, 23 Nov 2006 07:00:00 +0100 285856 http://www.medworm.com/index.php?rid=277598&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F7 Conclusions: In the normal formalin-fixed and paraffin embedded canine liver hepatic portal MF and HSC can be identified by alpha-SMA, HHF35 and to a lesser extent desmin immunostaining. These antibodies can thus be used in further studies on hepatic fibrosis. Synaptophysin, GFAP and NCAM do not seem suitable for marking of canine HSC. The positivity of HSC for alpha-SMA and HHF35 in the normal canine liver may eventually reflect a more active regulation of hepatic sinusoidal flow by these HSC compared to other species. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=277598 Thu, 16 Nov 2006 07:00:00 +0100 277598 http://www.medworm.com/index.php?rid=265484&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F6 The transcriptome is the mRNA transcript pool in a cell, organ or tissue with the liver transcriptome being amongst the most complex of any organ. Functional genomics methodologies are now being widely utilized to study transcriptomes including the hepatic transcriptome. This review outlines commonly used methods of transcriptome analysis, especially gene array analysis, focusing on publications utilizing these methods to understand human liver disease. Additionally, we have outlined the relationship between transcript and protein expressions as well as summarizing what is know about the variability of the transcriptome in non-diseased liver tissue. The approaches covered include gene array analysis, serial analysis of gene expression, subtractive hybridization and differential display. Th... Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=265484 Tue, 07 Nov 2006 07:00:00 +0100 265484 http://www.medworm.com/index.php?rid=248090&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F5 Conclusions: We show that ET-1 stimulates fibrogenic gene expression for 1st passage HSC and it inhibits HSC proliferation for 4th passage HSC. These data indicate the profibrogenic and antifibrogenic action of ET-1 for HSC are involved in the process of liver fibrosis. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=248090 Tue, 24 Oct 2006 06:00:00 +0100 248090 http://www.medworm.com/index.php?rid=217691&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F4 Conclusions: Genotypes 3a and 1a in Iran are less prevalent in IVDU than in Europe and USA, but there is a high similarity between the pattern of genotype in IVDU in both Europe and United States, and Iran. However, in this case it can not be due to people migration among countries since history of travel abroad existed only in 6 cases (13.3%). (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=217691 Mon, 02 Oct 2006 06:00:00 +0100 217691 http://www.medworm.com/index.php?rid=91187&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F2 Conclusions: Expression of fetal AFP could be demonstrated during liver development and during proliferation of the so-called oval cells. Changes of expression of orphan nuclear receptors, however, did not correlate with AFP expression. Other regulatory pathways were possibly involved in controlling AFP expression, in vivo. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=91187 Wed, 05 Jul 2006 06:00:00 +0100 91187 http://www.medworm.com/index.php?rid=87765&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F2 Conclusions: Expression of fetal AFP could be demonstrated during liver development and during proliferation of the so-called oval cells. Changes of expression of orphan nuclear receptors, however, did not correlate with AFP expression. Other regulatory pathways were possibly involved in controlling AFP expression, in vivo. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=87765 Wed, 05 Jul 2006 06:00:00 +0100 87765 http://www.medworm.com/index.php?rid=14877&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F5%2F1%2F1 Conclusion: In patients with cirrhosis, adefovir resistance can lead to severe hepatitis. Tenofovir appears to be an effective treatment of adefovir resistant mutants. Incomplete control of viral replication with adefovir requires monitoring for viral resistance and should prompt a change in antiviral treatment. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14877 Wed, 11 Jan 2006 07:00:00 +0100 14877 http://www.medworm.com/index.php?rid=14878&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F10 Conclusion: SteatoTest is a simple and non-invasive quantitative estimate of liver steatosis and may reduce the need for liver biopsy, particularly in patients with metabolic risk factor. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14878 Fri, 23 Dec 2005 07:00:00 +0100 14878 http://www.medworm.com/index.php?rid=14879&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F9 Conclusion: During treatment with Peg-IFN alpha-2a plus ribavirin in genotype 1 patients, when the main objective of the treatment is viral eradication, viral kinetics showed that week 2 appeared to be the best time point for predicting SVR. Our results must be further confirmed on a larger cohort. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14879 Wed, 21 Dec 2005 07:00:00 +0100 14879 http://www.medworm.com/index.php?rid=14880&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F8 Substantial recent experimental evidence has demonstrated the existence of reciprocal interactions between the microvascular bed of a specific organ and intravascular metastatic tumor cells through expression of adhesion molecules and nitric oxide release, resulting in a significant impact upon metastatic outcomes.This review summarizes the current findings of adhesive and cytotoxic endothelial-tumor cell interactions in the liver, the inducibility, zonal distribution and sinusoidal structural influences on the hepatic endothelial regulatory functions, and the effects of these functions on the formation of liver cancer metastases. New insights into the traditional cancer metastatic cascade are also discussed. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14880 Fri, 09 Dec 2005 07:00:00 +0100 14880 http://www.medworm.com/index.php?rid=14881&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F7 Conclusion: The pathophysiological differences between CPSS and PPVH can adequately be explained by the Q-PCR measurements and Western blots. Although c-MET levels were reduced, downstream signaling seemed to be functional and provides a rational for HGF-supplementation in controlled studies with CPSS and PPVH. Furthermore both diseases may serve as simplified models for comparison with more complex chronic inflammatory diseases and cirrhosis. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14881 Wed, 07 Dec 2005 07:00:00 +0100 14881 http://www.medworm.com/index.php?rid=14882&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F6 Conclusion: In the validation set, HA was accurate in predicting significant fibrosis, severe fibrosis, and cirrhosis with AUCs of 0.73, 0.77, and 0.97, respectively. Moreover, accurate HA level cut-offs were defined for predicting significant fibrosis, severe fibrosis, and cirrhosis. Thus, the study supports that HA level may be clinically useful as a non-invasive marker for liver fibrosis and/or cirrhosis. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14882 Mon, 11 Jul 2005 06:00:00 +0100 14882 http://www.medworm.com/index.php?rid=14884&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F4 Conclusion: Since rainbow trout hepatic DTD activity is inducible by both monofunctional and bifunctional inducers, it is suggested that rainbow trout DTD may be regulated by the same mechanisms, as in mammals. The fact that DTD is inducible in rainbow trout suggests that the enzyme may be suitable as a part of a biomarker battery when rainbow trout is used in environmental studies. It appears as if DTD activity in rainbow trout is higher and inducible compared to the other fish species studied. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14884 Wed, 04 May 2005 06:00:00 +0100 14884 http://www.medworm.com/index.php?rid=14883&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F5 Conclusion: In spite of the absence of architectural distortion, and a normal proliferative index, the possibility of premalignancy or malignancy should be considered in this type of hypervascular and hyposiderotic nodule, occurring in the context of an iron overloaded liver. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14883 Wed, 04 May 2005 06:00:00 +0100 14883 http://www.medworm.com/index.php?rid=14885&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F3 Conclusion: In the DH group the expression of gene products involved in copper efflux was significantly reduced, which might explain the high hepatic copper levels in this disease. ROS defences were most likely impaired in the CASH and DH group. Overall, this study describes a new variant of primary copper toxicosis and could provide a molecular basis for equating future treatments in dog and in man. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14885 Thu, 24 Mar 2005 07:00:00 +0100 14885 http://www.medworm.com/index.php?rid=14886&cid=s_30392_17_f&fid=30392&url=http%3A%2F%2Fwww.comparative-hepatology.com%2Fcontent%2F4%2F1%2F2 Conclusions: Ketoconazole, nonylphenol and ethynylestradiol all interacted with CYP1A and CYP3A activities and protein expression in Atlantic cod. However, mechanisms of interactions on CYP1A and CYP3A differ between theses substances and combined exposure had different effects than exposure to single compounds. Thus, CYP1A and CYP3A mediated clearance may be impaired in situations of mixed exposure to those types of compounds. (Source: Comparative Hepatology) Comparative Hepatology journals http://www.medworm.com/rss/comments.php?id=14886 Tue, 08 Feb 2005 07:00:00 +0100 14886