MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Coordination Chemistry Reviews' source. Sat, 20 Mar 2010 15:50:30 +0100 http://www.medworm.com/index.php?rid=3284207&cid=s_37313_51_f&fid=37313&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20161508%26dopt%3DAbstract We report a quantitative theoretical analysis of long-range electron transfer through sensitizer wires bound in the active-site channel of cytochrome P450cam. Each sensitizer wire consists of a substrate group with high binding affinity for the enzyme active site connected to a ruthenium-diimine through a bridging aliphatic or aromatic chain. Experiments have revealed a dramatic dependence of electron transfer rates on the chemical composition of both the bridging group and the substrate. Using combined molecular dynamics simulations and electronic coupling calculations, we show that electron tunneling through perfluorinated aromatic bridges is promoted by enhanced superexchange coupling through virtual reduced states. In contrast, electron flow through aliphatic bridges occurs by hole-med... Coordination Chemistry Reviews journals http://www.medworm.com/rss/comments.php?id=3284207 Mon, 01 Feb 2010 00:00:00 +0100 3284207 http://www.medworm.com/index.php?rid=3146525&cid=s_37313_51_f&fid=37313&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20047011%26dopt%3DAbstract Authors: Milacic V, Dou QP Although cisplatin plays a vital role in the treatment of several types of human cancer, its wide use is limited by the development of drug resistance and associated toxic side effects. Gold and gold complexes have been used to treat a wide range of ailments for many centuries. In recent years, the use of gold(III) complexes as an alternative to cisplatin treatment was proposed due to the similarities of gold and platinum. Gold(III) is isoelectronic with platinum(II) and gold(III) complexes have the same square-planar geometries as platinum(II) complexes, such as cisplatin. Although it was originally thought that gold(III) complexes might have the same molecular target as cisplatin, several lines of data indicated that proteins, rather than DNA, are targeted ... Coordination Chemistry Reviews journals http://www.medworm.com/rss/comments.php?id=3146525 Thu, 01 Jan 2009 00:00:00 +0100 3146525 http://www.medworm.com/index.php?rid=2135202&cid=s_37313_51_f&fid=37313&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19169375%26dopt%3DAbstract Authors: Gokel GW, Daschbach MM Hydraphiles are synthetic ionophores that were designed to mimic some properties of protein channels that conduct such cations as sodium. They use macrocyclic (crown) polyethers as amphiphilic headgroups and as entry and exit portals. Their overall length is controlled by covalent links between the two headgroups (distal macrocycles) and the "central relay" unit, typically also an azacrown. The hydraphiles insert in the bilayer membranes of synthetic phospholipid vesicles or vital cells and mediate the transport of cations. The hydraphiles were intended to be models but they are functional channels. Because they are symmetric, they are non-rectifying but they show open-close behavior characteristic of natural channels. Because they are non-rectifying, wh... Coordination Chemistry Reviews journals http://www.medworm.com/rss/comments.php?id=2135202 Tue, 01 Apr 2008 04:00:00 +0100 2135202 http://www.medworm.com/index.php?rid=2041734&cid=s_37313_51_f&fid=37313&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19081816%26dopt%3DAbstract Authors: Mullins CS, Pecoraro VL Recent advances in the study of the Oxygen Evolving Complex (OEC) of Photosystem II (PSII) include structural information attained from several X-ray crystallographic (XRD) and spectroscopic (XANES and EXAFS) investigations. The possible structural features gleaned from these studies have enabled synthetic chemists to design more accurate model complexes, which in turn, offer better insight into the possible pathways used by PSII to drive photosynthetic water oxidation catalysis. Mononuclear model compounds have been used to advance the knowledge base regarding the physical properties and reactivity of high-valent (Mn(IV) or Mn(V)) complexes. Such investigations have been especially important in regard to the manganyl (Mn(IV)=O or Mn(V) identical withO)... Coordination Chemistry Reviews journals http://www.medworm.com/rss/comments.php?id=2041734 Fri, 01 Feb 2008 05:00:00 +0100 2041734 http://www.medworm.com/index.php?rid=1570472&cid=s_37313_51_f&fid=37313&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18496594%26dopt%3DAbstract Authors: Debus RJ Photosynthetic water oxidation is catalyzed by a unique Mn(4)Ca cluster in Photosystem II. The ligation environment of the Mn(4)Ca cluster optimizes the cluster's reactivity at each step in the catalytic cycle and minimizes the release of toxic, partly oxidized intermediates. However, our understanding of the cluster's ligation environment remains incomplete. Although the recent X-ray crystallographic structural models have provided great insight and are consistent with most conclusions of earlier site-directed mutagenesis studies, the ligation environments of the Mn(4)Ca cluster in the two available structural models differ in important respects. Furthermore, while these structural models and the earlier mutagenesis studies agree on the identity of most of the Mn(4)C... Coordination Chemistry Reviews journals http://www.medworm.com/rss/comments.php?id=1570472 Fri, 01 Feb 2008 05:00:00 +0100 1570472