MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Current Gerontology and Geriatrics Research' source. Wed, 08 Feb 2012 16:54:22 +0100 http://www.medworm.com/index.php?rid=5545158&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fecam%2F2012%2F258434%2F Melastoma malabathricum L. (Melastomataceae) is one of the 22 species found in the Southeast Asian region, including Malaysia. Considered as native to tropical and temperate Asia and the Pacific Islands, this commonly found small shrub has gained herbal status in the Malay folklore belief as well as the Indian, Chinese, and Indonesian folk medicines. Ethnopharmacologically, the leaves, shoots, barks, seeds, and roots of M. malabathricum have been used to treat diarrhoea, dysentery, hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabthricum, such as antinociceptive, anti-inflammatory, wound healing, antidiarrheal, cytotoxic, and antioxidant activities. Various types of phytochemical constit... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5545158 Wed, 28 Dec 2011 13:22:12 +0100 5545158 http://www.medworm.com/index.php?rid=5538634&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fijrc%2F2011%2F342532%2F This paper deals with an FPGA implementation of a high performance FM modulator and demodulator for software defined radio (SDR) system. The individual component of proposed FM modulator and demodulator has been optimized in such a way that the overall design consists of a high-speed, area optimized and low-power features. The modulator and demodulator contain an optimized direct digital frequency synthesizer (DDFS) based on quarter-wave symmetry technique for generating the carrier frequency with spurious free dynamic range (SFDR) of more than 64 dB. The FM modulator uses pipelined version of the DDFS to support the up conversion in the digital domain. The proposed FM modulator and demodulator has been implemented and tested using XC2VP30-7ff896 FPGA as a target device and can oper... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5538634 Sun, 25 Dec 2011 09:58:25 +0100 5538634 http://www.medworm.com/index.php?rid=5538633&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Facmp%2F2011%2F574979%2F Results of a study of PbxS1−x alloys and films with various Pb content have been reported and discussed. Films of PbxS1−x of thickness 1.5 μm have been deposited on glass substrates by flash thermal evaporation method at room temperature, under vacuum at constant deposition rate. These films were annealed under vacuum around 10−6 Torr at different temperatures up to 523 K. The composition of the elements in PbxS1−x alloys was determined by standard surfaces techniques such as atomic absorption spectroscopy (AAS) and X-ray fluorescence (XRF), and the results were found of high accuracy and in very good agreement with the theoretical values. The structure for alloys and films is determined by using X-ray diffraction. This measurement reveals... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5538633 Sun, 25 Dec 2011 09:58:25 +0100 5538633 http://www.medworm.com/index.php?rid=5538632&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fjam%2F2011%2F658282%2F The piecewise algebraic curve, as the set of zeros of a bivariate spline function, is a generalization of the classical algebraic curve. In this paper, an algorithm is presented to compute the real solutions of two piecewise algebraic curves. It is primarily based on the Krawczyk-Moore iterative algorithm and good initial iterative interval searching algorithm. The proposed algorithm is relatively easy to implement. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5538632 Sun, 25 Dec 2011 09:58:25 +0100 5538632 http://www.medworm.com/index.php?rid=5538631&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fana%2F2011%2F703435%2F We present an incomplete UL (IUL) decomposition of matrix A which is extracted as a by-product of BFAPINV (backward factored approximate inverse) process. We term this IUL factorization as IULBF. We have used ILUFF [3] and IULBF as left preconditioner for linear systems. Different versions of ILUFF and IULBF preconditioners are computed by using different dropping techniques. In this paper, we compare quality of different versions of ILUFF and IULBF preconditioners. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5538631 Sun, 25 Dec 2011 09:58:25 +0100 5538631 http://www.medworm.com/index.php?rid=5538630&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fmpe%2F2011%2F793429%2F Experimental data are often very complex since the underlying dynamical system may be unknown and the data may heavily be corrupted by noise. It is a crucial task to properly analyze data to get maximal information of the underlying dynamical system. This paper presents a novel principal component analysis (PCA) method based on symplectic geometry, called symplectic PCA (SPCA), to study nonlinear time series. Being nonlinear, it is different from the traditional PCA method based on linear singular value decomposition (SVD). It is thus perceived to be able to better represent nonlinear, especially chaotic data, than PCA. Using the chaotic Lorenz time series data, we show that this is indeed the case. Furthermore, we show that SPCA can conveniently reduce measurement noise. (Source: Current ... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5538630 Sun, 25 Dec 2011 09:58:25 +0100 5538630 http://www.medworm.com/index.php?rid=5362544&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fsrcm%2F2011%2F847409%2Fabs%2F One important mechanism by which cancer cells parasitize their host is by escaping apoptosis. Thus, selectively facilitating apoptosis is a therapeutic mechanism by which oncotherapy may prove highly advantageous. One major apoptotic pathway is mediated by Fas ligand (FasL). The death-inducing signaling Ccmplex (DISC) and subsequent death-domain aggregations are created when FasL is bound by its receptor thereby enabling programmed cell death. Conceptually, if a better understanding of the Fas pathway can be garnered, an oncoselective prodeath therapeutic approach can be tailored. Herein, we propose that EGF and CTGF play essential roles in the regulation of the Fas apoptotic pathway in sarcomas. Tumor and in vitro data suggest viable cells counter the prodeath signal induced by FasL by ac... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5362544 Tue, 01 Nov 2011 23:40:12 +0100 5362544 http://www.medworm.com/index.php?rid=5274730&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fphys%2F2011%2F128429%2F The neutron production in thick targets irradiated with 1 GeV protons was studied experimentally, and results are well understood with model calculations, including MCNPX 2.7a. However, one observes very large neutron production rates in the interaction of 44 GeV 12C onto thick Cu-, Pb-, and U-targets beyond calculated rates. The experimental spallation product yield curve in a 20 cm thick Cu target irradiated with 72 GeV 40Ar also cannot be reproduced by several model codes, including MCNPX 2.7a. This may be due to secondary fragments produced in high energy (Ekinetic>10 GeV) heavy-ion interactions which destroy target nuclei more effectively than primary ions. These observed experimental facts constitute “unresolved problems” from a f... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=5274730 Mon, 03 Oct 2011 08:58:59 +0100 5274730 http://www.medworm.com/index.php?rid=4239027&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F614814.html We describe a mechanism that explains the synergism. The concept of “thrifty genotype” is a plausible explanation of XBM in the elderly Hmong immigrants and possibly the current older Laotian population. POH is common among elderly Laotians as it is in most developing countries. We conclude that synergism of XBM and POH significantly elevates the prevalence of diabetes among aging populations and probably other age groups as well. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=4239027 Wed, 08 Dec 2010 16:55:58 +0100 4239027 http://www.medworm.com/index.php?rid=4014950&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F381637.html It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties of age trajectories of the physiological indices could also be important contributors to morbidity and mortality risks. In this paper we use data on longitudinal changes in body mass index, diastolic blood pressure, pulse pressure, pulse rate, blood glucose, hematocrit, and serum cholesterol in the Framingham Heart Study participants, to investigate this possibility in depth. We found that some of the variables describing individual dynamics of the age-associated changes in physiological indices influence human longevity and exceptional health... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=4014950 Thu, 30 Sep 2010 14:49:51 +0100 4014950 http://www.medworm.com/index.php?rid=4006049&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F680657.html While it is understood that longevity and health are influenced by complex interactions among biological, psychological, and sociological factors, there is a general lack of understanding on how psychosocial factors impact longevity, health, and quality of life among the oldest old. One of the reasons for this paradox is that the amount of funded research on aging in the US is significantly larger in the biomedical compared to psychosocial domains. The goals of this paper are to highlight recent data to demonstrate the impact of four pertinent psychosocial domains on health and quality of life of the oldest old and supplement recommendations of the 2001 NIA Panel on Longevity for future research. The four domains highlighted in this paper are (1) demographics, life events, and personal his... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=4006049 Wed, 29 Sep 2010 14:20:31 +0100 4006049 http://www.medworm.com/index.php?rid=3966857&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F340161.html Many studies have demonstrated that social relationships confer mental health benefits. This paper aims to identify whether and how reciprocity in social relationships predicts or is associated with mental health benefits as well as with continuity in elderly people's social relationships. The studies reviewed in this paper show that, among elders, being in a balanced or underbenefited reciprocal position predicts better mental health and life quality than being in an overbenefited position. Throughout the course of life, reciprocity evens out present and earlier reciprocal imbalances, securing continuity in close relationships—particularly between spouses and between elderly parents and adult children. In friendships, securing continuity seems to be based on the maintenance of... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3966857 Wed, 15 Sep 2010 06:12:47 +0100 3966857 http://www.medworm.com/index.php?rid=3966856&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F310610.html Centenarians display a broad variation in physical abilities, from independence to bed-bound immobility. This range of abilities makes it difficult to evaluate functioning using a single instrument. Using data from a population-based sample of 244 centenarians (MAge = 100.57 years, 84.8% women, 62.7% institutionalized, and 21.3% African American) and 80 octogenarians (MAge = 84.32 years, 66.3% women, 16.3% institutionalized, and 17.5% African American) we (1) provide norms on the Short Physical Performance Battery and (2) extend the range of this scale using performance on additional tasks and item response theory (IRT) models, reporting information on concurrent and predictive validity of this approach. Using the original SPPB scoring criteria, 73.0% of centena... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3966856 Wed, 15 Sep 2010 06:12:47 +0100 3966856 http://www.medworm.com/index.php?rid=3966855&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F989315.html Used a population-based sample (Georgia Centenarian Study, GCS), to determine proportions of centenarians reaching 100 years as (1) survivors (43%) of chronic diseases first experienced between 0–80 years of age, (2) delayers (36%) with chronic diseases first experienced between 80–98 years of age, or (3) escapers (17%) with chronic diseases only at 98 years of age or older. Diseases fall into two morbidity profiles of 11 chronic diseases; one including cardiovascular disease, cancer, anemia, and osteoporosis, and another including dementia. Centenarians at risk for cancer in their lifetime tended to be escapers (73%), while those at risk for cardiovascular disease tended to be survivors (24%), delayers (39%), or escapers (32%). Approximately half (43%) of the centenarians did ... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3966855 Wed, 15 Sep 2010 06:12:47 +0100 3966855 http://www.medworm.com/index.php?rid=3922468&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F127605.html Discussion. The risk factors found in the study can be interpreted as the primary predictors for death among elderly members of the community. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3922468 Thu, 02 Sep 2010 06:21:29 +0100 3922468 http://www.medworm.com/index.php?rid=3818635&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F503817.html Information about recent visual decline (RVD) and its consequences is limited. The aim was to investigate this in an observational, prospective study. Participants were recipients of community home services, ≥65 years, from Ontario (Canada, n=101618), Finland (the-RAI-database, STAKES, n=1103), and 10 other European countries (the-Aged-in-HOmeCarestudy (AdHOC), n=3793). The instrument RAI-HC version 2.0 was used in all sites. RVD was assessed by the item “Worsening of vision compared to status 90 days ago” and was present in 6–49% in various sites, more common among persons living alone, and in females. In the AdHOC sample, RVD was independently associated with declining social activity and limited outdoors activities due to fear of falling. The combination of... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3818635 Thu, 05 Aug 2010 05:58:43 +0100 3818635 http://www.medworm.com/index.php?rid=3786606&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F358531.html Nonagenarians and centenarians represent a quickly growing age group worldwide. In parallel, the prevalence of dementia increases substantially, but how to define dementia in this oldest-old age segment remains unclear. Although the idea that the risk of Alzheimer's disease (AD) decreases after age 90 has now been questioned, the oldest-old still represent a population relatively resistant to degenerative brain processes. Brain aging is characterised by the formation of neurofibrillary tangles (NFTs) and senile plaques (SPs) as well as neuronal and synaptic loss in both cognitively intact individuals and patients with AD. In nondemented cases NFTs are usually restricted to the hippocampal formation, whereas the progressive involvement of the association areas in the temporal neocortex... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3786606 Mon, 26 Jul 2010 05:47:57 +0100 3786606 http://www.medworm.com/index.php?rid=3679337&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F348174.html Lung cancer is the leading cause of cancer-related mortality in both men and women and approximately 219,440 new cases of nonsmall cell lung cancer (NSCLC) were estimated to occur in the USA in 2009, which caused 159,390 NSCLC-related deaths. More than 50% of cases of advanced NSCLC are diagnosed in patients older than age 65, and recent Surveillance Epidemiology and End Results (SEERs) data suggest that the median age at diagnosis is 70 years. Until recently, the disease has been undertreated in this patient population, with a perception among many clinicians that elderly patients do not tolerate chemotherapy or radiotherapy. So, single agent chemotherapy is the recommended approach by the ASCO and International Expert Panels in unselected patients. The introduction of novel targeted ... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3679337 Mon, 21 Jun 2010 05:42:52 +0100 3679337 http://www.medworm.com/index.php?rid=3637901&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F915296.html Conclusions. Various factors may account for the failure to provide appropriate treatment, including a lack of awareness of clinical benefits and perceived safety issues. However, if current guidelines are followed and older patients treated to appropriate LDL-C goals, the likelihood of cardiovascular events will be reduced in this high-risk population. Employing an evidence-based approach to the management of cardiovascular risk in older patients is likely to yield benefits in terms of overall cardiovascular burden. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3637901 Tue, 08 Jun 2010 13:23:28 +0100 3637901 http://www.medworm.com/index.php?rid=3597091&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F510614.html Executive function (EF) is believed to control or influence the integration and application of cognitive functions such as attention and memory and is an important area of research in cognitive aging. Recent studies and reviews have concluded that there is no single test for EF. Results from first-order latent variable modeling have suggested that little, if any, variability in cognitive performance can be directly (and uniquely) attributed to EF; so instead, we modeled EF, as it is conceptualized, as a higher-order function, using elements of the CERAD neuropsychological battery. Responses to subtests from two large, independent cohorts of nondemented elderly persons were modeled with three theoretically plausible structural models using confirmatory factor analysis. Robust fit statistics... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3597091 Wed, 26 May 2010 13:21:10 +0100 3597091 http://www.medworm.com/index.php?rid=3597090&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F701897.html In conclusion, caution due to previous experience may increase attentional demand during dual tasks and lengthen the time required for central nervous processing in order to avoid losing postural stability in older adults, resulting in reductions in step velocity and step length compared to those in young adults. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3597090 Wed, 26 May 2010 13:21:10 +0100 3597090 http://www.medworm.com/index.php?rid=3527894&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F420139.html We present here a description of age-related disruption of lipid homeostasis, which particularly affects 3-hydroxy 3-methylglutaryl Coenzyme A reductase, the key rate-limiting enzyme in the cholesterol biosynthetic pathway. We further discuss the age- and gender-related dysregulation of this enzyme, providing new evidence for the different mechanisms driving dyslipidemia in elderly men and women. In addition, we introduce pharmacological methods of regulating HMGR and maintaining cholesterol homeostasis. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3527894 Tue, 04 May 2010 13:19:21 +0100 3527894 http://www.medworm.com/index.php?rid=3457498&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F219683.html Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potent... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3457498 Sun, 11 Apr 2010 13:19:37 +0100 3457498 http://www.medworm.com/index.php?rid=3422357&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F230697.html The proteasome is considered the most important proteolytic system for removal of damaged proteins with aging. Using fluorogenic peptide substrates, the chymotrypsin-like, the trypsin-like, and the peptidylglutamyl peptidase activities of the proteasome were measured in the soluble fractions of liver, brain, and lens rat homogenates. Specific activity was significantly decreased in liver and brain homogenates with maturation of the animal, that is, from newborn (7 days old) to fertile rats (2–4 months old). Rat lens homogenate exhibited an increase in activity with maturation and also with aging. Chymotrypsin-like activity was stimulated by calcium and this proteolytic activity was significantly decreased with maturation of the rat brain. The Michaelis-Menten constant (Km) increased ... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3422357 Wed, 31 Mar 2010 13:37:30 +0100 3422357 http://www.medworm.com/index.php?rid=3324536&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F927503.html We report 3 consecutive elderly patients successfully treated with recombinant activated factor VII and standard immunosuppressive regimens, with remission of the disease. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3324536 Wed, 03 Mar 2010 14:32:48 +0100 3324536 http://www.medworm.com/index.php?rid=3274016&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F475958.html Conclusion. Ageing stereotypes can also form medical illness concepts and have a significant influence on diagnostic and therapeutic decisions. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3274016 Tue, 16 Feb 2010 14:27:05 +0100 3274016 http://www.medworm.com/index.php?rid=3225790&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F298950.html Purpose. To present the psychometric properties of a new measure of quality of life in older age, the Older People's Quality of Life (OPQOL) Questionnaire, compared with the CAPSE-19 and the WHOQOL-OLD. Design and Methods. The vehicle was three national population surveys of older people living at home in Britain, including a survey of ethnically diverse older people. Results. The OPQOL had acceptable levels of reliability and validity in British population samples of older people, but more modest in the ethnically diverse population sample. The CASP-19 and WHOQOL-OLD had acceptable levels of reliability and validity in the British population sample, but not in the ethnically diverse sample. Implications. The OPQOL has potential for use as a multidimensional population surveillance ins... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3225790 Mon, 01 Feb 2010 14:59:12 +0100 3225790 http://www.medworm.com/index.php?rid=2928850&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F156820.html The aim of this study was to examine the effects of resistance training on hematological blood markers in older individuals. Twenty-nine men and women participated to this study. Subjects were randomized in 2 groups: (1) control (n=13) and (2) resistance training (n=16). At baseline and after the intervention, subjects were submitted to a blood sample to determine their hematological profile (red blood cells, hemoglobin, hematocrit, platelets, leukocytes, neutrophils, lymphocytes, monocytes, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width). At baseline, no difference was observed between groups. Moreover, we found no significant difference after the intervention on any of these markers. A 6-month resistance progra... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2928850 Tue, 27 Oct 2009 14:24:23 +0100 2928850 http://www.medworm.com/index.php?rid=2928849&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F858415.html Bronchial asthma is a common problem with enormous medical and economics impacts. It is an inflammatory disease of the airways associated with intermittent episodes of bronchospasm. Asthma is not uncommon in the elderly patients. Prevalence of asthma is similar in older and younger adults. Asthma in the elderly patient is underdiagnosed because of false perceptions by both patient and physician. The high incidence of comorbid conditions in the elderly patient makes the diagnosis and management more difficult. Correct diagnosis is demonstrated with spirometry. The goals of asthma treatment are to achieve and maintain control of symptoms and to prevent development of irreversible airflow limitation. Asthma drugs are preferably inhaled because this route minimizes systemic absorption and, thu... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2928849 Tue, 27 Oct 2009 14:24:23 +0100 2928849 http://www.medworm.com/index.php?rid=2769437&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F608740.html Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual phenotype is adaptively more appropriate to the anticipated environment. Thus, maternal and/or neonatally derived nutritional or endocrine cues suggesting a threatening environment may favour early growth and reproduction over investment in tissue reserve and repair capacity. These may directly affect longevity, as well as prioritise insulin resistance and capacity for fat storage, thereby increasing susceptibility to metabolic dysfunction and obesity. These shifts in developmental trajectory are associated with long-term expression changes in specific genes, some of which may be underpinned by epige... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2769437 Sun, 06 Sep 2009 16:34:28 +0100 2769437 http://www.medworm.com/index.php?rid=2465528&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F754190.html Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1-/- mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP-1-/- mice. The incidence of spontaneous tumors in both PARP-1-/- and PARP-1+/+ groups is similar; however, malignant tumors including uterine tumors, lu... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465528 Tue, 09 Jun 2009 17:49:38 +0100 2465528 http://www.medworm.com/index.php?rid=2465527&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F848267.html Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new rou... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465527 Tue, 09 Jun 2009 17:49:38 +0100 2465527 http://www.medworm.com/index.php?rid=2465526&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F474618.html Conclusions. It is probable in old and very old individuals who are on their highest level of maturity that the character represents the most important regulatory system in the encounter with challenges of daily life, which necessitates rehabilitation. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465526 Tue, 09 Jun 2009 17:49:38 +0100 2465526 http://www.medworm.com/index.php?rid=2465525&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F474868.html We summarize here the studies examining the association between thyroid function and cognitive performance from an aging perspective. The available data suggest that there may be a continuum in which cognitive dysfunction can result from increased or decreased concentrations of thyroid hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, attention, and reaction time. Mild variations of thyroid function, even within normal limits, can have significant consequences for cognitive function in the elderly. Different cognitive deficits possibly related to thyroid failure do not necessarily follow a consistent pattern, and L-... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465525 Tue, 09 Jun 2009 17:49:38 +0100 2465525 http://www.medworm.com/index.php?rid=2465524&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F858759.html Insulin degrading enzyme (IDE) degrades amyloid β (Aβ), which may inhibit the accumulation of Aβ in a brain affected with dementia of Alzheimer's type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstrated using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). IDE gene polymorphism is unlikely to play a substantial role in conferring suscep... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465524 Tue, 09 Jun 2009 17:49:38 +0100 2465524 http://www.medworm.com/index.php?rid=2465523&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F158425.html Conclusions. HDL-C was associated with dismal prognosis in men but not in women. Elderly men with HDL-C  <40 mg/dL deserve particular attention for cardiovascular prevention. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465523 Tue, 09 Jun 2009 17:49:38 +0100 2465523 http://www.medworm.com/index.php?rid=2012007&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F858759 Insulin degrading enzyme (IDE) degrades amyloid β (Aβ), which may inhibit the accumulation of Aβ in a brain affected with dementia of Alzheimer's type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstrated using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). IDE gene polymorphism is unlikely to play a substantial role in conferring suscep... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2012007 Thu, 04 Dec 2008 17:22:23 +0100 2012007 http://www.medworm.com/index.php?rid=1750809&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F474868 We summarize here the studies examining the association between thyroid function and cognitive performance from an aging perspective. The available data suggest that there may be a continuum in which cognitive dysfunction can result from increased or decreased concentrations of thyroid hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, attention, and reaction time. Mild variations of thyroid function, even within normal limits, can have significant consequences for cognitive function in the elderly. Different cognitive deficits possibly related to thyroid failure do not necessarily follow a consistent pattern, and L-... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1750809 Tue, 02 Sep 2008 13:45:58 +0100 1750809 http://www.medworm.com/index.php?rid=1714714&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F474618 Conclusions. It is probable in old and very old individuals who are on their highest level of maturity that the character represents the most important regulatory system in the encounter with challenges of daily life, which necessitates rehabilitation. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1714714 Tue, 19 Aug 2008 14:02:48 +0100 1714714 http://www.medworm.com/index.php?rid=1489545&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F754190 Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1-/- mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP-1-/- mice. The incidence of spontaneous tumors in both PARP-1-/- and PARP-1+/+ groups is similar; however, malignant tumors including uterine tumors, lu... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1489545 Tue, 03 Jun 2008 22:12:10 +0100 1489545 http://www.medworm.com/index.php?rid=1489544&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F848267 Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new rou... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1489544 Tue, 03 Jun 2008 22:12:10 +0100 1489544