MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Current Gerontology and Geriatrics Research' source. Sun, 21 Mar 2010 15:09:40 +0100 http://www.medworm.com/index.php?rid=3324536&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2010%2F927503.html We report 3 consecutive elderly patients successfully treated with recombinant activated factor VII and standard immunosuppressive regimens, with remission of the disease. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3324536 Wed, 03 Mar 2010 14:32:48 +0100 3324536 http://www.medworm.com/index.php?rid=3274016&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F475958.html Conclusion. Ageing stereotypes can also form medical illness concepts and have a significant influence on diagnostic and therapeutic decisions. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3274016 Tue, 16 Feb 2010 14:27:05 +0100 3274016 http://www.medworm.com/index.php?rid=3225790&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F298950.html Purpose. To present the psychometric properties of a new measure of quality of life in older age, the Older People's Quality of Life (OPQOL) Questionnaire, compared with the CAPSE-19 and the WHOQOL-OLD. Design and Methods. The vehicle was three national population surveys of older people living at home in Britain, including a survey of ethnically diverse older people. Results. The OPQOL had acceptable levels of reliability and validity in British population samples of older people, but more modest in the ethnically diverse population sample. The CASP-19 and WHOQOL-OLD had acceptable levels of reliability and validity in the British population sample, but not in the ethnically diverse sample. Implications. The OPQOL has potential for use as a multidimensional population surveillance ins... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=3225790 Mon, 01 Feb 2010 14:59:12 +0100 3225790 http://www.medworm.com/index.php?rid=2928850&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F156820.html The aim of this study was to examine the effects of resistance training on hematological blood markers in older individuals. Twenty-nine men and women participated to this study. Subjects were randomized in 2 groups: (1) control (n=13) and (2) resistance training (n=16). At baseline and after the intervention, subjects were submitted to a blood sample to determine their hematological profile (red blood cells, hemoglobin, hematocrit, platelets, leukocytes, neutrophils, lymphocytes, monocytes, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width). At baseline, no difference was observed between groups. Moreover, we found no significant difference after the intervention on any of these markers. A 6-month resistance progra... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2928850 Tue, 27 Oct 2009 14:24:23 +0100 2928850 http://www.medworm.com/index.php?rid=2928849&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F858415.html Bronchial asthma is a common problem with enormous medical and economics impacts. It is an inflammatory disease of the airways associated with intermittent episodes of bronchospasm. Asthma is not uncommon in the elderly patients. Prevalence of asthma is similar in older and younger adults. Asthma in the elderly patient is underdiagnosed because of false perceptions by both patient and physician. The high incidence of comorbid conditions in the elderly patient makes the diagnosis and management more difficult. Correct diagnosis is demonstrated with spirometry. The goals of asthma treatment are to achieve and maintain control of symptoms and to prevent development of irreversible airflow limitation. Asthma drugs are preferably inhaled because this route minimizes systemic absorption and, thu... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2928849 Tue, 27 Oct 2009 14:24:23 +0100 2928849 http://www.medworm.com/index.php?rid=2769437&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F608740.html Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual phenotype is adaptively more appropriate to the anticipated environment. Thus, maternal and/or neonatally derived nutritional or endocrine cues suggesting a threatening environment may favour early growth and reproduction over investment in tissue reserve and repair capacity. These may directly affect longevity, as well as prioritise insulin resistance and capacity for fat storage, thereby increasing susceptibility to metabolic dysfunction and obesity. These shifts in developmental trajectory are associated with long-term expression changes in specific genes, some of which may be underpinned by epige... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2769437 Sun, 06 Sep 2009 16:34:28 +0100 2769437 http://www.medworm.com/index.php?rid=2465528&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F754190.html Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1-/- mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP-1-/- mice. The incidence of spontaneous tumors in both PARP-1-/- and PARP-1+/+ groups is similar; however, malignant tumors including uterine tumors, lu... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465528 Tue, 09 Jun 2009 17:49:38 +0100 2465528 http://www.medworm.com/index.php?rid=2465527&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F848267.html Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new rou... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465527 Tue, 09 Jun 2009 17:49:38 +0100 2465527 http://www.medworm.com/index.php?rid=2465526&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F474618.html Conclusions. It is probable in old and very old individuals who are on their highest level of maturity that the character represents the most important regulatory system in the encounter with challenges of daily life, which necessitates rehabilitation. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465526 Tue, 09 Jun 2009 17:49:38 +0100 2465526 http://www.medworm.com/index.php?rid=2465525&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F474868.html We summarize here the studies examining the association between thyroid function and cognitive performance from an aging perspective. The available data suggest that there may be a continuum in which cognitive dysfunction can result from increased or decreased concentrations of thyroid hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, attention, and reaction time. Mild variations of thyroid function, even within normal limits, can have significant consequences for cognitive function in the elderly. Different cognitive deficits possibly related to thyroid failure do not necessarily follow a consistent pattern, and L-... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465525 Tue, 09 Jun 2009 17:49:38 +0100 2465525 http://www.medworm.com/index.php?rid=2465524&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2008%2F858759.html Insulin degrading enzyme (IDE) degrades amyloid β (Aβ), which may inhibit the accumulation of Aβ in a brain affected with dementia of Alzheimer's type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstrated using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). IDE gene polymorphism is unlikely to play a substantial role in conferring suscep... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465524 Tue, 09 Jun 2009 17:49:38 +0100 2465524 http://www.medworm.com/index.php?rid=2465523&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2Fjournals%2Fcggr%2F2009%2F158425.html Conclusions. HDL-C was associated with dismal prognosis in men but not in women. Elderly men with HDL-C  <40 mg/dL deserve particular attention for cardiovascular prevention. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2465523 Tue, 09 Jun 2009 17:49:38 +0100 2465523 http://www.medworm.com/index.php?rid=2371149&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2009%2F158425 Conclusions. HDL-C was associated with dismal prognosis in men but not in women. Elderly men with HDL-C  <40 mg/dL deserve particular attention for cardiovascular prevention. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2371149 Wed, 29 Apr 2009 02:07:14 +0100 2371149 http://www.medworm.com/index.php?rid=2012007&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F858759 Insulin degrading enzyme (IDE) degrades amyloid β (Aβ), which may inhibit the accumulation of Aβ in a brain affected with dementia of Alzheimer's type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstrated using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). IDE gene polymorphism is unlikely to play a substantial role in conferring suscep... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=2012007 Thu, 04 Dec 2008 17:22:23 +0100 2012007 http://www.medworm.com/index.php?rid=1750809&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F474868 We summarize here the studies examining the association between thyroid function and cognitive performance from an aging perspective. The available data suggest that there may be a continuum in which cognitive dysfunction can result from increased or decreased concentrations of thyroid hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, attention, and reaction time. Mild variations of thyroid function, even within normal limits, can have significant consequences for cognitive function in the elderly. Different cognitive deficits possibly related to thyroid failure do not necessarily follow a consistent pattern, and L-... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1750809 Tue, 02 Sep 2008 13:45:58 +0100 1750809 http://www.medworm.com/index.php?rid=1714714&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F474618 Conclusions. It is probable in old and very old individuals who are on their highest level of maturity that the character represents the most important regulatory system in the encounter with challenges of daily life, which necessitates rehabilitation. (Source: Current Gerontology and Geriatrics Research) Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1714714 Tue, 19 Aug 2008 14:02:48 +0100 1714714 http://www.medworm.com/index.php?rid=1489545&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F754190 Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-1-/- mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP-1-/- mice. The incidence of spontaneous tumors in both PARP-1-/- and PARP-1+/+ groups is similar; however, malignant tumors including uterine tumors, lu... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1489545 Tue, 03 Jun 2008 22:12:10 +0100 1489545 http://www.medworm.com/index.php?rid=1489544&cid=s_37024_18_f&fid=37024&url=http%3A%2F%2Fwww.hindawi.com%2FGetArticle.aspx%3Fdoi%3D10.1155%2F2008%2F848267 Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new rou... Current Gerontology and Geriatrics Research journals http://www.medworm.com/rss/comments.php?id=1489544 Tue, 03 Jun 2008 22:12:10 +0100 1489544