MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Current Prostate Reports' source. Fri, 22 Jan 2010 14:23:59 +0100 http://www.medworm.com/index.php?rid=3032073&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F51680686x3n44w1u%2F This article presents a comprehensive overview of the current understanding of clinical and epidemiologic research on diabetes and BPH/LUTS, describes hypothesized pathophysiologic mechanisms linking these conditions, and recommends future directions for research and clinical care. Content Type Journal ArticleDOI 10.1007/s11918-009-0022-xAuthors Aruna V. Sarma, University of Michigan Departments of Urology and Epidemiology Room 1025, Michigan House, 2301 Commonwealth Boulevard Ann Arbor MI 48105 USAJ. Kellogg Parsons Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 7 Journal Issue Volume 7, Number 4 / December, 2009 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=3032073 Mon, 23 Nov 2009 16:47:23 +0100 3032073 http://www.medworm.com/index.php?rid=3032072&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7377gu3620428u1%2F This article gives an overview of these factors and attempts to give a common-sense, practical guide to a rehabilitation program. Content Type Journal ArticleDOI 10.1007/s11918-009-0021-yAuthors John P. Mulhall, Memorial Sloan-Kettering Cancer Center Male Sexual and Reproductive Medicine, Urology Service 1275 York Avenue New York NY 10065 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 7 Journal Issue Volume 7, Number 4 / December, 2009 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=3032072 Mon, 23 Nov 2009 16:47:23 +0100 3032072 http://www.medworm.com/index.php?rid=3032075&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu428u74k4v50h230%2F Abstract  Painful bladder syndrome (PBS), part of a symptom complex previously designated interstitial cystitis (IC), currently commands a position as perhaps the predominant disconcerting diagnostic and treatment dilemma encountered by urologists. Despite substantial advancements in our conceptualization of the PBS/IC disease assemblage, fundamental issues involving definitions and taxonomy continue to plague the field and deter progress. Herein we present select concepts from the forefront of PBS/IC deliberation to precipitate creation of a meaningful consensus that the urologic community can use to collaborate with other disciplines. An international effort is envisioned to develop a classification system that will serve to ease communication among practitioners, researc... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=3032075 Mon, 23 Nov 2009 16:47:20 +0100 3032075 http://www.medworm.com/index.php?rid=3032074&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc1254710n6k58g06%2F Abstract  Management of patients presenting with elevated serum prostate-specific antigen levels, or those with previously diagnosed prostate carcinoma, is very much dependent on the pathology report on needle biopsy or radical prostatectomy specimens obtained from these patients. In contrast to a diagnosis of benignity or high-grade prostatic intraepithelial neoplasia, a diagnosis of atypia on needle core biopsy is usually an indication for a repeat biopsy; however, it is important to understand that atypia and other related terms are not specific diagnoses. The pathology report on different prostate specimens with a diagnosis of carcinoma usually includes the Gleason grade and extent of carcinoma, among other morphological prognostic and predictive factors. Understanding ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=3032074 Mon, 23 Nov 2009 16:47:20 +0100 3032074 http://www.medworm.com/index.php?rid=3032077&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F38n2u44244qu0776%2F Abstract  Since the first transurethral resection of the prostate (TURP) was performed by Guyon at the Necker Hospital in Paris in 1901, this treatment modality has replaced open prostatectomy as the procedure of choice for more than 95% of patients. TURP has been used in surgical treatment of benign prostatic hyperplasia (BPH) and remains the gold standard treatment. Transurethral vapor resection of the prostate (TUVRP) and holmium laser enucleation of the prostate (HoLEP) are new treatment modalities for the treatment of BPH. Each procedure has its own advantages and disadvantages. Availability of instruments, surgical expertise, and specific indications for a particular procedure are of utmost importance for successful outcome, with minimal morbidity. TURP can be either ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=3032077 Mon, 23 Nov 2009 16:47:19 +0100 3032077 http://www.medworm.com/index.php?rid=3032076&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb374074m014r5428%2F This article reviews the contemporary issues that affect the diagnosis and treatment of urinary tuberculosis. Content Type Journal ArticleDOI 10.1007/s11918-009-0024-8Authors Gilbert J. Wise, Maimonides Medical Center Division of Urology 48-02 Tenth Avenue Brooklyn NY 11219 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 7 Journal Issue Volume 7, Number 4 / December, 2009 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=3032076 Mon, 23 Nov 2009 16:47:19 +0100 3032076 http://www.medworm.com/index.php?rid=2735820&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy147507r38020477%2F Abstract  Radiotherapy has been successful in treating localized prostate cancer; however, a subset of patients will experience disease recurrence. Determination of the recurrence location must be made using pretreatment and posttreatment clinical variables, imaging, and postradiotherapy biopsy. Patients presumed to have local-only recurrence, optimal clinical risk factors, and an extended life expectancy may be considered for salvage local treatment. Current options include salvage surgery, cryoablation, and brachytherapy. Although they are associated with higher morbidity than primary therapy, salvage treatments can be effective and can still provide patients with a good oncologic and functional outcome. As these modalities continue to improve and patient selection is opt... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2735820 Tue, 25 Aug 2009 17:02:43 +0100 2735820 http://www.medworm.com/index.php?rid=2735819&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0q3v722q1r88kx5w%2F Abstract  Radiation therapy modalities have been shown to offer patients a nonoperative option for definitive treatment of localized prostate cancer as well as options for adjuvant or salvage therapy in high-risk prostate cancer patients. In patients with high-risk, localized disease, radiation therapy with or without adjuvant hormonal therapy is considered an excellent treatment option because of its efficacy within the prostate and among local periprostatic structures, addressing micrometastatic disease. Following radical prostatectomy in patients with high-risk or recurrent disease, radiotherapy can increase oncologic efficacy in both the adjuvant and salvage setting. Continued studies are underway to address ongoing concerns of sparing surrounding tissues unnecessary ra... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2735819 Tue, 25 Aug 2009 17:02:43 +0100 2735819 http://www.medworm.com/index.php?rid=2735818&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8h62574754118234%2F Abstract  Treatment for men with lower urinary tract symptoms (LUTS) has developed into a “cascade” that escalates from watchful waiting through medical treatment to surgery. Self-management can help men to adopt lifestyle and behavioral modifications that will avoid or delay an escalation in treatment and reduce symptoms. Although many of these interventions are advised to men with LUTS, it is usually in a nonstand ardized and unsystematic way. Recent work in this area has defined a self-management program for men with uncomplicated LUTS using formal methods and assessed its effectiveness in a randomized controlled trial. Self-management significantly reduced the frequency of escalation through the treatment cascade and reduced urinary symptoms (as effective as medicat... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2735818 Tue, 25 Aug 2009 17:02:43 +0100 2735818 http://www.medworm.com/index.php?rid=2735821&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7718581748282770%2F Abstract  It has long been appreciated that a healthy lifestyle plays a critical role in cardiovascular health. It is now apparent that the same is true in the development of benign prostatic hyperplasia (BPH). Prospective cohort data originating from recently published randomized trials on the medical treatment of BPH and prevention of prostate cancer have been invaluable. A growing body of evidence suggests that exercise and the intake of specific macronutrients and micronutrients through regular diet play a beneficial role. Most strikingly, the magnitude of these effects is similar to medical therapies using α-blockers and 5-α-reductase inhibitors. The use of supplements for prostate disease is a multibillion dollar business in the United States, and supplements are mo... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2735821 Tue, 25 Aug 2009 17:02:42 +0100 2735821 http://www.medworm.com/index.php?rid=2735822&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn18794n3813h1048%2F This article reviews the manage ment of patients with elevated serum PSA and a diagnosis of chronic nonbacterial prostatitis. Content Type Journal ArticleDOI 10.1007/s11918-009-0018-6Authors Jaspreet S. Sandhu, Memorial Sloan-Kettering Cancer Center 353 East 68th Street New York NY 10021 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 7 Journal Issue Volume 7, Number 3 / September, 2009 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2735822 Tue, 25 Aug 2009 17:02:41 +0100 2735822 http://www.medworm.com/index.php?rid=2735823&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fev537p2516181834%2F Abstract  There is no one unifying etiological mechanism or specific curative therapy for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). However, there is sufficient evidence to suggest that each of the proposed mechanisms may be important in some patients, and that many of our evaluated treatments do in fact work in subgroups of patients. We hypothesize that CP/CPPS patients are not a homogenous group suffering from a single disease entity. Rather, CP/CPPS patients are actually unique individuals with differing clinical phenotypes based on various etiological mechanisms with distinctive symptom complexes and progression trajectories. We call this the “Snow Flake Hypothesis.” We propose the UPOINT (urinary, psychosocial, organ-specific, infection, neurologi... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2735823 Tue, 25 Aug 2009 17:02:40 +0100 2735823 http://www.medworm.com/index.php?rid=2638918&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl648x47652922150%2F Abstract  Obesity has emerged as a global public health challenge. During the past 20 years, there has been a dramatic increase in obesity in the United States. In 2007, only one state had a prevalence of obesity less than 20%. In this growing epidemic of national concern is an emerging relationship between lower urinary tract symptoms (LUTS), benign prostatic hyperplasia (BPH), and obesity. BPH is the most common neoplastic condition afflicting men and constitutes a major factor impacting the health of the American male. Associations among obesity, physical inactivity, and BPH/LUTS resulting from epidemiological studies have not been explored via clinical trial methodology. A review of the available data appears to support a strong independent relationship between obesity ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2638918 Fri, 24 Jul 2009 06:35:41 +0100 2638918 http://www.medworm.com/index.php?rid=2638917&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv383051530252367%2F Abstract  Urologists are routinely faced with the dilemma of a persistently worrisome clinical picture for prostate cancer in patients who have undergone prior negative ultrasound-guided prostate biopsies. Indications for repeat biopsy include sustained or worsening of the findings that prompted the initial biopsy; various derivations of prostate-specific antigen; and the histology from the initial biopsy (ie, high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferation is identified). Large prostate volume or inflammation can confound the decision to perform repeat biopsies. Repeat biopsies should include a combination of standard sextant, lateral, anterior apical, and possibly transition zone biopsies. Repeat biopsies should consist of at least 14... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2638917 Fri, 24 Jul 2009 06:35:41 +0100 2638917 http://www.medworm.com/index.php?rid=2638919&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc148134844403g43%2F Abstract  Chronic nonbacterial prostatitis, or urological chronic pelvic pain syndrome (UCPPS), remains a common and often challenging disorder to evaluate and treat. Employing a more holistic approach, including urological therapy, physical therapy, and psychosocial perspectives, may be more appropriate for most patients. Growing evidence supports the use of biofeedback, myofascial trigger point release, prescribed exercise regimens, relaxation techniques, and supportive counseling to treat men with UCPPS. Content Type Journal ArticleDOI 10.1007/s11918-009-0012-zAuthors Jeannette M. Potts, 31200 Pinetree Road Pepper Pike OH 44124 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 7 Journal Issue Volume 7, Nu... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2638919 Fri, 24 Jul 2009 06:35:40 +0100 2638919 http://www.medworm.com/index.php?rid=2638920&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh64w06747460457l%2F Abstract  Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is not well understood. The mechanisms involved in its pathophysiology have yet to be fully elucidated. Men with CP/CPPS suffer from symptoms that may not necessarily be linked to concurrent prostate involvement. Recent literature embraces the notion that symptoms may result from complex interactions, and studies have looked at other disease syndromes in an attempt to reveal the etiology of the disease. The title of this article suggests an organcentric etiology to explain symptoms of patients with this disorder, but this does not seem to be the case. In an attempt to answer the question, this article examines possible etiologies for CP/CPPS in which the prostate may be involved and discusses evaluation st... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2638920 Fri, 24 Jul 2009 06:35:33 +0100 2638920 http://www.medworm.com/index.php?rid=2638921&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh7j2578t46221063%2F This study provides clinicians with information on some chemoprevention agents that have been considered to reduce prostate cancer risks, including 5-α-reductase inhibitors; statins (a class of compounds used to reduce cholesterol); NSAIDs; selenium; vitamins E and D; lycopene; allium vegetables (garlic, scallions, onions, chives, and leeks); soy/isoflavones; and green tea polyphenols. The evidence to support prostate cancer risk reduction benefits for each chemoprevention agent based on a review of the literature is provided. Content Type Journal ArticleDOI 10.1007/s11918-009-0008-8Authors Janet L. Colli, University of Alabama at Birmingham 1530 3rd Avenue South Birmingham AL 35294 USAChristopher L. Amling Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 15... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2638921 Fri, 24 Jul 2009 06:35:31 +0100 2638921 http://www.medworm.com/index.php?rid=2638922&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4282187m1311353%2F Abstract  Medical and surgical therapies for benign prostatic hyperplasia (BPH) are based largely on the results from adherence to the 2003 American Urological Association Guidelines. However, with the emergence of medical therapies as first-line treatment and the expansion of medical therapy for lower urinary tract symptoms (LUTS) into the primary care office, the evaluation and management of men presenting with urinary symptoms can vary depending on provider type. This review explains the basis for BPH medical management in primary care with the review of three key studies. In addition, this review utilizes the data provided by the first longitudinal, observational BPH registry to evaluate patient outcomes and practice patterns in both urologist and primary care offices. ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2638922 Fri, 24 Jul 2009 06:35:30 +0100 2638922 http://www.medworm.com/index.php?rid=2183090&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj317070620767jp1%2F This article reviews the use of PSA velocity and PSA doubling time in several clinical scenarios. Content Type Journal ArticleDOI 10.1007/s11918-009-0003-0Authors Joseph Presti, Stanford University School of Medicine Urologic Oncology 875 Blake Wilbur Drive, Room CC-2217 Stanford CA 94305 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 7 Journal Issue Volume 7, Number 1 / February, 2009 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2183090 Wed, 11 Feb 2009 07:20:23 +0100 2183090 http://www.medworm.com/index.php?rid=2183092&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F17862h51v323p00n%2F Abstract  Recent evidence has indicated a significant link between benign prostatic hyperplasia (BPH) and sexual dysfunction (SD). Patients presenting with lower urinary tracts symptoms (LUTS) secondary to BPH should also be evaluated for comorbid SD, especially given the increasing basic science evidence demonstrating a common pathway for these two conditions. Therapy for BPH may exacerbate SD and should be selected carefully, with current data indicating a role for phosphodiesterase-5 inhibitors in the treatment of BPH. More long-term data are needed to determine the efficacy of the latest surgical therapies for BPH. The practice patterns of physicians differ slightly by specialty in the evaluation and treatment of patients with LUTS, but both groups significantly underes... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2183092 Wed, 11 Feb 2009 07:20:21 +0100 2183092 http://www.medworm.com/index.php?rid=2183091&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F90401049v7146485%2F Content Type Journal ArticleCategory Clinical Trials ReportDOI 10.1007/s11918-009-0001-2Authors Kevin T. McVary Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 7 Journal Issue Volume 7, Number 1 / February, 2009 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2183091 Wed, 11 Feb 2009 07:20:21 +0100 2183091 http://www.medworm.com/index.php?rid=2183093&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg5n813037l83r1qp%2F Abstract  Chronic pelvic pain syndrome (CPPS) describes unexplained pelvic pain in men associated with irritative voiding symptoms, post-orgasmic pain, and/or pain located in the groin, genitalia, or perineum in the absence of bacterial infection. Many different etiologies of CPPS have been proposed, including roles for immunologic, neurologic, endocrine, and psychologic factors. This article examines one such factor—ejaculatory duct obstruction (EDO). Because EDO is correctable with relatively minor surgery, it should be considered by any clinician caring for a patient who reports symptoms of CPPS. Content Type Journal ArticleDOI 10.1007/s11918-009-0006-xAuthors Harry Fisch, Columbia University 944 Park Avenue New York NY 10028 USA Journal Current Prostate Repo... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2183093 Wed, 11 Feb 2009 07:20:20 +0100 2183093 http://www.medworm.com/index.php?rid=2183094&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy2656g157555g255%2F Abstract  The prostate-specific antigen (PSA) screening era has seen dramatic stage and age migration in patients with newly diagnosed prostate cancer. The average serum PSA level of newly diagnosed patients is about 6 ng/dL, and 60% of patients are diagnosed with clinical stage T1c disease. There is evidence that many low-grade and low-stage prostate cancers have a slow growth rate and protracted clinical course, with a very low threat of metastasis or death over a prolonged interval. Many men are also appropriately concerned about the impact of prostate cancer treatment on sexual and urinary function. Therefore, delaying therapy in favor of careful surveillance, with the expectation of delivering curative treatment upon evidence of progression, is an attractive concept. I... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2183094 Wed, 11 Feb 2009 07:20:18 +0100 2183094 http://www.medworm.com/index.php?rid=2183095&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn491q8l201736815%2F Abstract  We are in the midst of a paradigm shift in the surgical management of benign prostatic hyperplasia (BPH). After decades of decline, there is a recent surge in the rate of BPH surgeries—largely represented by laser prostatectomy and office-based thermotherapies. In the United States, the number of transurethral resections of the prostate (TURP) continues to decline, now representing a minority of all procedures performed. We reflect on how such changes may affect resident training. We review education models that strive to maintain TURP proficiency amongst urology residents, despite fewer opportunities for training on live patients. Furthermore, we review how proposed changes in the structure of urology education might impact training in office-based procedures, ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2183095 Wed, 11 Feb 2009 07:20:17 +0100 2183095 http://www.medworm.com/index.php?rid=2183096&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn18356855mg21q75%2F Abstract  Chronic prostatitis/chronic pelvic pain syndrome continues to pose a treatment challenge for urologists. Chronic prostatitis is a very common and poorly understood condition with significant impact on quality of life. In recent literature, studies have been conducted with various treatment modalities that include antibiotics, α-blockers, anti-inflammatory agents, and cognitive behavioral interventions such as biofeedback and psychotherapy. Patients have shown interest in phytotherapy as a treatment option with increasing frequency due to lack of efficacy of conventional therapies. However, very little is known about the efficacy of second- and third-line treatments, such as the use of herbal supplements. We review published literature regarding phytotherapy usage... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=2183096 Wed, 11 Feb 2009 07:20:16 +0100 2183096 http://www.medworm.com/index.php?rid=1991498&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg2v66t3870285q45%2F Abstract  The association of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) with advancing age has drawn increased scrutiny over the past decade. Analysis of historical and emerging literature reveals a causal link between these two disease processes, but also raises further questions. Studies showing that phosphodiesterase (PDE) inhibitors improve LUTS offer the strongest evidence of a causal relationship. PDE inhibitors seem to exert a positive effect to a greater degree on detrusor activity rather than directly on the prostate. Four proposed mechanisms attempt to explain the relationship between ED and LUTS. Clarification of this relationship is essential in an increasingly older population because it affects patient screening and treatment. The future... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1991498 Tue, 25 Nov 2008 06:58:18 +0100 1991498 http://www.medworm.com/index.php?rid=1991497&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F97330pr6w660136u%2F Abstract  Our understanding of the relationship between diet and prostate cancer is still developing. Currently, randomized, controlled trials are under way that will yield evidence on which to base recommendations regarding dietary regimens, functional foods, and supplement use. For now, data mostly derive from epidemiologic investigations with limited ability to demonstrate cause and effect, or from benchtop research that may have limited application to in vivo systems, especially in humans. Insufficient evidence currently exists to support the use of specific dietary supplements or functional food. Clinicians striving for best clinical practice should therefore encourage weight management because data consistently show that overweight and obesity are associated with prog... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1991497 Tue, 25 Nov 2008 06:58:18 +0100 1991497 http://www.medworm.com/index.php?rid=1991496&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr2731053hv825752%2F Abstract  Chronic prostatitis and chronic pelvic floor pain are common, bothersome syndromes that nearly half of all American men will encounter in their lifetimes. In addition to pelvic floor pain, men experience various symptoms, including lower urinary tract symptoms, during voiding. Evaluation and classification is based on the National Institutes of Health criteria. Most cases have an inflammatory etiology, and successful identification of treatable cases can be challenging. Evaluation is currently evolving, with many cases requiring nontraditional testing, such as urodynamics. Because voiding dysfunction may exist concurrently, evaluation is crucial to enable symptom-improving intervention in treatable patients. Although many significant urodynamic findings exist, mos... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1991496 Tue, 25 Nov 2008 06:58:18 +0100 1991496 http://www.medworm.com/index.php?rid=1991495&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr25g712712608583%2F Content Type Journal ArticleDOI 10.1007/s11918-008-0022-2 Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 4 / November, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1991495 Tue, 25 Nov 2008 06:58:18 +0100 1991495 http://www.medworm.com/index.php?rid=1991494&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj2u662337q717w46%2F This article describes the evidence that GnRH agonists increase risk for diabetes and cardiovascular disease and reviews the potential mechanisms for treatment-related morbidity. Content Type Journal ArticleDOI 10.1007/s11918-008-0023-1Authors Matthew R. Smith, Massachusetts General Hospital Cancer Center Yawkey Center 7038 55 Fruit Street Boston MA 02114 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 4 / November, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1991494 Tue, 25 Nov 2008 06:58:18 +0100 1991494 http://www.medworm.com/index.php?rid=1991499&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F048w2h0j64g3k35t%2F Abstract  Category III prostatitis, also known as chronic pelvic pain syndrome (CPPS), is a common condition of unclear etiology and few validated effective therapies. It is even controversial whether all patients with CPPS have prostatic pathology. Prostatic calcifications/stones are common in older, asymptomatic men but are seen with a high frequency in young men with CPPS. This review examines the current literature on ultrasound findings in men with CPPS and discusses possible implications for etiology and therapy. Content Type Journal ArticleDOI 10.1007/s11918-008-0027-xAuthors Alvin WeeDaniel A. Shoskes, Glickman Urological and Kidney Institute Cleveland Clinic 9500 Euclid Avenue, Desk A100 Cleveland OH 44195 USA Journal Current Prostate ReportsOnline ISSN 1... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1991499 Tue, 25 Nov 2008 06:58:17 +0100 1991499 http://www.medworm.com/index.php?rid=1886628&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F326037j48u271238%2F This article reviews evidence of BTX-A safety and efficacy in the treatment of LUTS related to BPH. Results are also presented from our first phase 1, dose-escalating study to evaluate the dose-related toxicity of BTX-A to treat LUTS due to BPH. Ultimately, the LUTS-related improvements seen in our study were consistent with earlier published trials using BTX-A to treat LUTS. Content Type Journal ArticleDOI 10.1007/s11918-008-0018-yAuthors Al B. Barqawi, University of Colorado Health Science Center, Anschutz Cancer Pavilion Section of Urologic Oncology 1665 North Ursula Street, Suite 1004 PO Box 6510, Mail Stop F-710 Aurora CO 80045 USAE. David Crawford Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Vol... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1886628 Thu, 16 Oct 2008 09:59:20 +0100 1886628 http://www.medworm.com/index.php?rid=1886627&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk786025083385245%2F Abstract  The potential ability of statin medications to prevent cancer has recently received considerable attention. Of all cancers studied, data for prostate cancer are the most promising. Results from studies examining the association between statin use and reduced risk of prostate cancer have been encouraging, particularly in terms of advanced prostate cancer risk. These findings are supported by a strong foundation of scientific evidence demonstrating the potential cholesterol and non-cholesterol-mediated mechanisms through which statins may prevent prostate cancer. In this article, we analyze recent human data regarding the association between statins and prostate cancer, and the basic scientific data supporting the possible antineoplastic mechanisms of statins. We al... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1886627 Thu, 16 Oct 2008 09:59:20 +0100 1886627 http://www.medworm.com/index.php?rid=1886626&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc07858x06064q217%2F Content Type Journal ArticleDOI 10.1007/s11918-008-0015-1 Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 3 / August, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1886626 Thu, 16 Oct 2008 09:59:20 +0100 1886626 http://www.medworm.com/index.php?rid=1886625&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv770515124mk12pk%2F Abstract  Controversy remains regarding the preferred therapy for high-risk, clinically localized prostate cancer. High-risk prostate cancer represents a diverse disease entity for which accurate risk assessment is critical to informed counseling and clinical decision making. For men with high-risk features, electing surgery as a local definitive therapy should be based on the best available evidence rather than a surgeon’s bias and experience. Patients classified with high-risk prostate cancer by common definitions do not have a uniformly poor prognosis after radical prostatectomy. Many cancers that are clinically categorized as high risk are actually pathologically confined to the prostate, and most of these men do not require additional long-term therapy after surgery.... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1886625 Thu, 16 Oct 2008 09:59:20 +0100 1886625 http://www.medworm.com/index.php?rid=1886624&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv10g0217t4g28h17%2F Abstract  Finasteride is an antiandrogen that inhibits 5-α-reductase, an enzyme that converts testosterone to dihydrotestosterone. Finasteride significantly reduces intraoperative bleeding when 10 mg/d is administered for 60 days before transurethral resection of the prostate. Our double-blind, randomized, placebo-controlled study evaluated 200 patients with benign prostatic hyperplasia who underwent transurethral resection of the prostate. We compared a placebo group (n = 100) with a group (n = 100) administered 5 mg of finasteride twice a day for 8 weeks. We intended to demonstrate the mechanisms and effects of finasteride compared with those of vascular endothelial growth factor, and to evaluate CD34, an immunohistochemical marker of blood vessel density in the prostate.... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1886624 Thu, 16 Oct 2008 09:59:20 +0100 1886624 http://www.medworm.com/index.php?rid=1886630&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa3873l8v806gt632%2F This article reviews the evaluation and treatment of MPPS and sexual dysfunction in men. Content Type Journal ArticleDOI 10.1007/s11918-008-0020-4Authors Darius A. Paduch, Weill Cornell Medical College Department of Urology 525 East 68th Street, F-924A New York NY 10065 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 3 / August, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1886630 Thu, 16 Oct 2008 09:59:19 +0100 1886630 http://www.medworm.com/index.php?rid=1886629&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa2713338h7746152%2F This report defines urologic chronic pelvic pain syndrome and examines pelvic muscular tension with associated myofascial trigger point pain. We describe a proposed alternative treatment approach to promote physiotherapy and cognitive-behavioral modification as the foundation of treatment. Options of invasive needleapplied neurologic manipulation are also recounted. Content Type Journal ArticleDOI 10.1007/s11918-008-0021-3Authors Rodney U. Anderson, Stanford University School of Medicine Department of Urology, S287 Stanford CA 94305 USA Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 3 / August, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1886629 Thu, 16 Oct 2008 09:59:19 +0100 1886629 http://www.medworm.com/index.php?rid=1488685&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F975032074574j062%2F Content Type Journal ArticleDOI 10.1007/s11918-008-0008-0 Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 2 / May, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1488685 Sat, 31 May 2008 06:54:48 +0100 1488685 http://www.medworm.com/index.php?rid=1488688&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg87660q54k512775%2F This article reviews the medical treatment of symptomatic BPH and discusses the rationale, outcome, and withdrawal time of initial α-blockers following combination therapy. Content Type Journal ArticleDOI 10.1007/s11918-008-0012-4Authors Ehab A. ElzayatMostafa M. Elhilali, Royal Victoria Hospital, MUHC Urology Division, Department of Surgery 687 Pine Avenue West, Room S6.95 H3A 1A1 Montreal Quebec Canada Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 2 / May, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1488688 Sat, 31 May 2008 06:54:46 +0100 1488688 http://www.medworm.com/index.php?rid=1488687&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq566147632418815%2F Abstract  Data regarding the molecular response of prostate cancer to hormone therapy continue to emerge, identifying a complex network of autocrine and paracrine signaling events mediating the tumor response to androgen suppression. Emerging data provide insight into cellular pathways important in the apoptotic response to therapy, including the transforming growth factor-β, insulin-like growth factor-1, and vascular endothelial growth factor signaling axes. They also reveal mechanisms of direct antitumor cytotoxicity mediated by various hormonal agents and highlight the importance of developing antiandrogens capable of irreversibly inhibiting the androgen receptor. Accumulated data emphasize the presence of residual androgens and persistent activation of androgen recepto... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1488687 Sat, 31 May 2008 06:54:46 +0100 1488687 http://www.medworm.com/index.php?rid=1488686&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F198p080374528p16%2F Abstract  Type III prostatitis (chronic prostatitis/chronic pelvic pain syndrome) is the most common form of prostatitis, accounting for 8% to 15% of urology outpatient office visits. Symptoms, including pain in the perineum, suprapubic region, testicles, or tip of the penis, are often exacerbated by urination or ejaculation. Currently available therapies have limited effectiveness in alleviating these symptoms. Further, there is an unexplained association between type III prostatitis and other unexplained somatic symptoms. Due to its high prevalence and lack of effective therapies, direct and indirect costs associated with type III prostatitis are substantial. Content Type Journal ArticleDOI 10.1007/s11918-008-0013-3Authors J. Quentin Clemens, University of Michigan Me... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1488686 Sat, 31 May 2008 06:54:46 +0100 1488686 http://www.medworm.com/index.php?rid=1488689&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F847555337724h126%2F Abstract  Prostate cancer is one of the most prevalent malignancies affecting men in the developed world. A spectrum of disease states exists and management is tailored to individual patients. Increasing public awareness and prostate-specific antigen testing have led to earlier detection and the possibility of cure but have increased the risk of overtreatment of indolent disease. Advances in curative modalities have reduced side effects and offer patients a choice of treatments. Nonetheless, many need no intervention and may be safely treated with active monitoring. Choice and timing of therapy for locally advanced and recurrent disease are variable, with potential benefits of early intervention counterbalanced by side effects of treatment. Progress has been made in the man... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1488689 Sat, 31 May 2008 06:54:45 +0100 1488689 http://www.medworm.com/index.php?rid=1488690&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F06622q31802n5473%2F Abstract  Inflammation is a common finding in histologic prostate specimens obtained from aging men. Accumulating data suggest that inflammation may play an important role in the development of benign prostatic hyperplasia (BPH), and the development and progression of lower urinary tract symptoms (LUTS). Inflammatory processes may contribute to prostatic enlargement directly through stimulation of prostate growth, or, alternatively, through decreasing prostatic apoptosis. Inflammatory processes may also impact other components of the urogenital tract, such as the bladder, and contribute to LUTS regardless of the presence of prostate enlargement. Therefore, current research offers clues about converging inflammatory pathways that may be targeted to improve treatment of BPH a... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1488690 Sat, 31 May 2008 06:54:44 +0100 1488690 http://www.medworm.com/index.php?rid=1488691&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy842983464w72213%2F Abstract  Atypical infections of the prostate are infrequently recognized or cultured. However, clinical evidence points to their occult role in the pathogenesis of prostatitis. Atypical infections of the prostate can be caused by gram-positive and gram-negative bacteria, Mycoplasma, Chlamydia, fungi and Mycobacterium tuberculosis that are not classically associated with prostatitis. Increasing evidence suggests that viruses, protozoans, and various zoonoses also play an important role in prostatic infections. Bacterial 16S ribosomal DNA found in patients with chronic prostatitis suggests a bacterial inflammatory event that initiates an autoimmune process. Prostatitis may also cause elevated levels of prostate-specific antigen, a prostate cancer tumor marker. Hence, determin... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1488691 Sat, 31 May 2008 06:54:42 +0100 1488691 http://www.medworm.com/index.php?rid=1338170&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft73t138382242286%2F Abstract  Complications of locally advanced prostate cancer are often overlooked in the overall treatment of prostate cancer, can have significant morbidity, and can provide a challenge for the treating urologist. Despite advances in early detection and treatment of prostate cancer, as many as 10% of patients present with or develop symptomatic locally advanced prostate cancer. Prostate cancer locally invading the urethra can be effectively managed with transurethral resection or ablation procedures or urethral stenting. Obstruction of one or both ureters is managed with either ureteral stenting or nephrostomy drainage. Bulky pelvic recurrence resulting in significant hematuria, rectal involvement, or severe pelvic pain can be difficult to manage, with some advocating cysto... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1338170 Sun, 30 Mar 2008 06:18:03 +0100 1338170 http://www.medworm.com/index.php?rid=1338168&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj6v42578431jw427%2F Abstract  The number of men for whom testosterone is prescribed is rapidly increasing. The aging man normally demonstrates a gradual decline in testosterone. Symptoms of hypogonadism include erectile dysfunction, diminished libido, sarcopenia, increased adiposity, osteopenia and osteoporosis, impaired cognition, and depression. There is a paucity of data regarding both efficacy and safety of testosterone replacement therapy. Testosterone levels have been shown to modulate prostate cancer risk and progression. A prospective evaluation of prostate cancer risk with testosterone replacement therapy has not been conducted. We outline concerns and recommendations for the use of testosterone replacement therapy in the aging man. Content Type Journal ArticleDOI 10.1007/s11918-008... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1338168 Sun, 30 Mar 2008 06:18:03 +0100 1338168 http://www.medworm.com/index.php?rid=1338176&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr40h77810n8171x6%2F Content Type Journal ArticleDOI 10.1007/s11918-008-0001-7 Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 6 Journal Issue Volume 6, Number 1 / February, 2008 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1338176 Sun, 30 Mar 2008 06:18:02 +0100 1338176 http://www.medworm.com/index.php?rid=1338174&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F22398014gx17475v%2F Abstract  Once primary treatment fails, the diverse causes and symptoms of chronic pelvic pain syndrome require clinicians to consider several secondary approaches. Multimodal therapy addresses unique symptoms and targets illness origin. However, once medical modalities fail, minimally invasive therapies should be considered, including transurethral needle ablation hyperthermia, cooled thermotherapy, electromagnetic chair, prostatic massage, and intraprostatic botulinum toxin A injection. Low evidence levels exist for all approaches, but we anticipate promising results of larger trials for cooled thermotherapy and look forward to the emergence of experimental techniques using botulinum toxin A. Content Type Journal ArticleDOI 10.1007/s11918-008-0006-2Authors Christof Ka... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1338174 Sun, 30 Mar 2008 06:18:02 +0100 1338174 http://www.medworm.com/index.php?rid=1338172&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa51292145737g560%2F Abstract  As the average age of the US population increases, the number of men with benign prostatic hyperplasia will also rise. Lower urinary tract symptoms are found in almost all men as they age, yet we do not have a dependable means to detect, classify, and predict potential response to therapy and disease progression. A molecular biomarker, JM-27, may address some of these needs. Serum levels of JM-27 detect disease and differentiate among disease states as classified by the associated symptoms. Although larger validation studies to more extensively characterize this test are under way, current data suggest that JM-27 differentiates men with highly symptomatic disease from those with asymptomatic disease. Content Type Journal ArticleDOI 10.1007/s11918-008-0004-4Autho... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1338172 Sun, 30 Mar 2008 06:18:02 +0100 1338172 http://www.medworm.com/index.php?rid=1338180&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9706418g10725417%2F Abstract  Congenital prostatic abnormalities are not commonly encountered in clinical practice but can provide insight into normal prostatic development. Furthermore, understanding normal prostate embryology and molecular signaling may provide novel approaches to the treatment of prostatic neoplasia. This review examines normal fetal development and congenital pathology of the prostate, including 5-α-reductase deficiency, prostatic ectopia, the prostate in the female pseudohermaphrodite, the prostate in prune belly syndrome, prostatic utricle, and trisomy syndromes. Content Type Journal ArticleDOI 10.1007/s11918-008-0007-1Authors Gregory E. Dean, Temple University Children’s Medical Center Department of Urology 3509 North Broad Street Philadelphia PA 19140 USA ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1338180 Sun, 30 Mar 2008 06:18:01 +0100 1338180 http://www.medworm.com/index.php?rid=1338178&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh522381657637473%2F Abstract  α-Blockers, the current common treatment for lower urinary tract symptoms (LUTS), are also used to treat bladder outlet obstruction (BOO), but the effect is not as clinically significant as in LUTS. All currently marketed phosphodiesterase type 5 (PDE5) inhibitors have recently been shown to significantly affect LUTS, although BOO-related efficacy has not been determined. Therefore, the extent of a causal relationship between LUTS and underlying benign prostatic enlargement (BPE) is questionable. LUTS may also be interpreted as symptoms related to detrusor overactivity, especially when no significant BOO is associated with BPE. Research is required to understand the efficacy of PDE5 inhibitors in LUTS but not in BOO. For vardenafil, nonclinical experiments and in... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1338178 Sun, 30 Mar 2008 06:18:01 +0100 1338178 http://www.medworm.com/index.php?rid=1017817&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9q1114r42g37431v%2F Abstract  A significant number of men with prostate cancer will experience biochemical failure following treatment with primary radiation therapy. For patients with biopsyproven recurrent cancer confined to the prostate, local salvage therapy may be a potentially curative treatment option. Most men, however, do not undergo local salvage therapy owing to difficulties in diagnosis as well as concerns over treatment-related complications in the salvage setting. Recently, improvements in technique and technology have substantially reduced the morbidity associated with local ablative therapies, resulting in an increased interest in the use of minimally invasive therapies such as brachytherapy, cryotherapy, and high-intensity focused ultrasound in the salvage setting. Although th... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1017817 Wed, 07 Nov 2007 15:25:53 +0100 1017817 http://www.medworm.com/index.php?rid=1017816&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F117126841u302878%2F Abstract  Prostatitis accounts for almost 2 million office visits to urologists and primary care physicians. The label “prostatitis” refers to a diverse constellation of symptoms and disease processes. The diagnosis and treatment of this disorder present numerous challenges for the physician, including a lack of abnormal findings on physical examination, laboratory tests, and radiographic images. In this article, we offer a review of the current literature and recommendations for the evaluation and diagnosis of the patient presenting with prostatitis. Content Type Journal ArticleDOI 10.1007/s11918-007-0025-4Authors Jason R. RothmanWilliam I. Jaffe, Temple University Department of Urology 3401 North Broad Street, 3rd Floor, Parkinson Pavilion, Suite 350 Philadelphia P... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1017816 Wed, 07 Nov 2007 15:25:53 +0100 1017816 http://www.medworm.com/index.php?rid=1017815&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq17h3204401j7534%2F The objective is to provide the clinician with an assessment of peer-reviewed evidence-based data to facilitate informed decision making on patient treatment for obstructive BPH. Content Type Journal ArticleDOI 10.1007/s11918-007-0023-6Authors Mark D. Stovsky, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center Department of Urology 11100 Euclid Avenue Cleveland OH 44106 USAKatherine RheeDavid Hartke Journal Current Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal Volume Volume 5 Journal Issue Volume 5, Number 4 / November, 2007 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1017815 Wed, 07 Nov 2007 15:25:53 +0100 1017815 http://www.medworm.com/index.php?rid=1017814&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F862u128521j73137%2F Abstract  Prostate cancer and chronic prostatitis are prevalent disorders in men. The cause of prostate cancer and chronic prostatitis is multifocal and diverse. Both disorders exhibit characteristic elevation of serum prostate-specific antigen, currently the primary screening test for prostate cancer. Prostate inflammation, regardless of cause, is the histopathologic hallmark of chronic prostatitis. In general, inflammation is associated with multiple cancers, and prostate inflammation, in particular, is a suggested factor in the development and progression of prostate cancer. This review addresses the link between chronic prostatitis and prostate cancer, especially as it relates to clinical practice. Content Type Journal ArticleDOI 10.1007/s11918-007-0026-3Authors Jas... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1017814 Wed, 07 Nov 2007 15:25:53 +0100 1017814 http://www.medworm.com/index.php?rid=1017813&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg35224520l1r9740%2F Abstract  Open or transurethral resection of the prostate was once the only option for men afflicted with symptomatic benign prostatic hyperplasia (BPH). In the past 10 to 15 years, however, medical management has become a common step in the treatment of BPH, often postponing or eliminating the need for surgical intervention. The two drug classes used in the medical management of BPH are α-blockers and 5-α-reductase inhibitors. This paper reviews major studies related to the use of these medications in combination and discusses patient populations best served by combination therapy. Content Type Journal ArticleDOI 10.1007/s11918-007-0024-5Authors Joseph C. ClarkeTimothy R. YoostHarry S. Clarke, Medical University of South Carolina Department of Urology 96 Jonathon Luca... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1017813 Wed, 07 Nov 2007 15:25:53 +0100 1017813 http://www.medworm.com/index.php?rid=1017812&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0737trq047172r05%2F Abstract  Over the past several years, the morbidity associated with radical prostatectomy has improved due to advances in surgical technique, better understanding of male pelvic anatomy, and improved perioperative care. Despite these advances, patients are still at risk for several complications both intraoperatively and in the postoperative course. These risks include significant blood loss, rectal injury, ureteral injury, thromboembolic events, urinary incontinence, impotence, and a perioperative death rate of less than 1%. These risks should be reviewed and discussed before treating the patient with prostate cancer. Content Type Journal ArticleDOI 10.1007/s11918-007-0021-8Authors Penner SchraudenbachCarlos E. Bermejo, The University of Texas Health Science Center at ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=1017812 Wed, 07 Nov 2007 15:25:53 +0100 1017812 http://www.medworm.com/index.php?rid=822779&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw017027411626371%2F Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 5 Journal IssueVolume 5, Number 3 / August, 2007 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=822779 Fri, 24 Aug 2007 14:16:41 +0100 822779 http://www.medworm.com/index.php?rid=822780&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu46916745x307530%2F Abstract  Chronic prostatitis/chronic pelvic pain syndrome remains an enigmatic medical condition. Creation of the National Institutes of Health-funded Chronic Prostatitis Collaborative Research Network (CPCRN) has stimulated a renewed interest in research on and clinical aspects of chronic prostatitis/chronic pelvic pain syndrome. Landmark publications of the CPCRN document a decade of progress. Insights from these CPCRN studies have improved our management of chronic prostatitis/chronic pelvic pain syndrome and offer hope for continued progress. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 5 Journal IssueVolume 5, Number 3 / August, 2007 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=822780 Fri, 24 Aug 2007 14:16:40 +0100 822780 http://www.medworm.com/index.php?rid=822783&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe1847488m6003121%2F Abstract  Although the causes of chronic prostatistis/chronic pelvic pain syndrome, painful bladder syndrome/interstitial cystitis, and overactive bladder remain unclear, inflammation may explain some of the causative and propagating features. Cytokines may play a role by recruiting inflammatory cells and ultimately in inducing symptoms. This paper reviews the role of cytokines in the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome, overactive bladder, and painful bladder syndrome/interstitial cystitis. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 5 Journal IssueVolume 5, Number 3 / August, 2007 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=822783 Fri, 24 Aug 2007 14:16:23 +0100 822783 http://www.medworm.com/index.php?rid=822778&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa1003643771tr3hh%2F Abstract  Patients with skeletal metastases from all sites are increasing in number as the treatment protocols for primary tumors improve survival of patients with cancer. While diagnosis and follow-up of the patient with urologic skeletal metastasis continue to become more sophisticated with new MRI techniques and the advent of positron emission tomography, the goal of orthopedic treatment remains the same: pain relief and maintenance of mobility. This paper describes the pathogenesis of metastasis followed by strategies currently available for accurately diagnosing, treating, and following the patient with skeletal metastases secondary to urologic malignancy. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Jo... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=822778 Fri, 24 Aug 2007 14:16:21 +0100 822778 http://www.medworm.com/index.php?rid=822782&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F517419g07608730k%2F Abstract  Despite the fact that almost all men will develop symptoms associated with benign prostatic hyperplasia within their lifetimes, no molecular markers for the disease or its likelihood to progress have been established. A marker of this type could be used to stratify patients into subpopulations as well as to identify individuals whose disease is most likely to progress. Several molecular biomarkers have high potential to fulfill these needs, although none is currently approved for the clinical setting. The future does look promising as research to find novel biologic biomarkers is progressing while existing markers are optimized and validated for clinical use. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=822782 Fri, 24 Aug 2007 14:16:07 +0100 822782 http://www.medworm.com/index.php?rid=822781&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8552273417060v8%2F Abstract  Detrusor overactivity is associated with aging and benign prostatic obstruction and often causes the troublesome symptoms of urgency and urgency incontinence (overactive bladder), persistent detrusor overactivity after transurethral resection of the prostate being the cause of more than a third of poor symptomatic outcomes following surgery. Most of the evidence currently suggests that neurons of the urothelium at the bladder neck play a significant role in the genesis of detrusor overactivity. Treatment options including botulinum toxin injections and intravesical vanilloids have been studied in the treatment of persistent detrusor overactivity, but further studies are needed specifically in patients with persistent detrusor overactivity after transurethral resec... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=822781 Fri, 24 Aug 2007 14:16:04 +0100 822781 http://www.medworm.com/index.php?rid=822777&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc12l25583659h7r3%2F Abstract  Radical retropubic prostatectomy and radiation therapy remain the mainstay of treatment for localized prostate cancer. However, with the advent of the Internet, more patients are arriving in physicians’ offices questioning novel techniques for their treatment that they otherwise would not have discovered. This paper discusses several of these techniques, including focal cryotherapy, high-intensity focused ultrasound, robotic-assisted laparoscopic prostatectomy, diets, supplements, and hormonal therapy. We also render our opinion on their efficacy for treatment based on the available published studies. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 5 Journal IssueVolume 5, Nu... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=822777 Fri, 24 Aug 2007 14:15:51 +0100 822777 http://www.medworm.com/index.php?rid=779127&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1768j1w635kpv578%2F Abstract  Locally advanced prostate cancer generally refers to those patients with clinical stages T3-4 disease. Patients with locally advanced cancer frequently are included in clinical trials that examine treatment for patients at high risk for relapse based on presenting prostate-specific antigen, high Gleason score, or advanced clinical stage. There is a growing body of evidence that suggests that men with localized prostate cancer benefit from high-dose radiation therapy delivered with three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, or proton beam therapy. Most importantly, neoadjuvant and adjuvant androgen-deprivation therapy have significantly improved outcomes in men with locally advanced or high-risk prostate cancer. Although q... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779127 Sun, 03 Jun 2007 07:16:47 +0100 779127 http://www.medworm.com/index.php?rid=779125&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9830166162r7m777%2F Abstract  Medical therapy is currently the most popular treatment choice for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Because medical therapy of BPH-related LUTS is considered a life-long strategy, short- and long-term cost considerations should play a major role in therapeutic decision-making. The effectiveness in terms of long and short amelioration of symptoms, flow rate, and quality of life are well documented for 5α-blockers and 5α-reductase inhibitors as well as for the gold standard treatment for BPH, transurethral resection of the prostate and minimally invasive therapies. Short-and long-term safety concerns also are well documented for these various treatment options. On the contrary, short- and long-term costs have ... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779125 Sun, 03 Jun 2007 07:16:47 +0100 779125 http://www.medworm.com/index.php?rid=779131&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq504263812422801%2F Abstract  Most prostate biopsies do not show malignancy. The proper management of non-cancerous pathologic findings of the prostate is controversial. For this article, we reviewed the current literature for indications for repeat prostate biopsy after initial biopsies demonstrated noncancerous prostatic tissue or benign prostatic hyperplasia. This review includes discussions of management of asymptomatic prostatitis and how it may affect prostate-speci.c antigen, and also the management of several potentially premalignant lesions such as atrophy, atypical small acinar proliferation, and high-grade prostatic intraepithelial neoplasia. There is a paucity of randomized trials in this area and, considering the high number of biopsies with nonmalignant findings, we conclude that... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779131 Sun, 03 Jun 2007 07:16:45 +0100 779131 http://www.medworm.com/index.php?rid=779128&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg475545227q73275%2F Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 4 Journal IssueVolume 4, Number 3 / September, 2006 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779128 Sun, 03 Jun 2007 07:16:44 +0100 779128 http://www.medworm.com/index.php?rid=779129&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8647p12117414525%2F Abstract  Increasing evidence recently has pointed toward a relationship between lower urinary tract symptoms (LUTS) and the presence of metabolic syndrome. This relationship has been supported by recent epidemiologic findings. Possible pathophysiologic links also have been proposed to explain the relationship between these two syndromes. The increasing prevalence of obesity in the United States makes this an increasingly relevant problem. Animal studies support a link between autonomic nervous system (ANS) overactivity and the development of urinary symptoms, low bladder compliance, compensatory prostatic hyperplasia, and blockage of the same using α-blockade. There appears to be a significant link between ANS overactivity as part of the metabolic syndrome and LUTS second... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779129 Sun, 03 Jun 2007 07:16:43 +0100 779129 http://www.medworm.com/index.php?rid=779126&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F03v70256616k3kx3%2F Abstract  Interstitial cystitis and chronic prostatitis/chronic pelvic pain syndrome are clinical syndromes characterized by pelvic pain with or without voiding symptoms such as urgency and frequency. There are many similarities in their epidemiology, adverse effect on quality of life, etiology/pathophysiology, natural history, and response to similar treatments. However, overlapping clinical definitions and similar entrance criteria for large-scale cohort studies make comparisons problematic. Newer efforts to classify pelvic pain syndromes should help in our recognition that interstitial cystitis and chronic prostatitis/chronic pelvic pain syndrome likely are not organ-specific syndromes but urogenital manifestations of regional or systemic abnormalities. Content TypeJou... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779126 Sun, 03 Jun 2007 07:16:42 +0100 779126 http://www.medworm.com/index.php?rid=779130&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy646p63r4957t001%2F Abstract  Prostatitis accounts for almost two million of.ce visits to urologists and primary care physicians. The label "prostatitis" refers to a diverse constellation of symptoms and disease processes. The diagnosis and treatment of this disorder presents numerous challenges for the physician, including a lack of abnormal .ndings on physical examination, laboratory tests, and radiographic images. In this article, we offer a review of the current literature and recommendations for the evaluation and diagnosis of the patient presenting with prostatitis. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 4 Journal IssueVolume 4, Number 3 / September, 2006 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779130 Sun, 03 Jun 2007 07:16:40 +0100 779130 http://www.medworm.com/index.php?rid=779140&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq9405g63575q0hv8%2F Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 1 Journal IssueVolume 1, Number 1 / July, 2003 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779140 Sat, 02 Jun 2007 07:42:55 +0100 779140 http://www.medworm.com/index.php?rid=779135&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy48u0kw865701l81%2F Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 1 Journal IssueVolume 1, Number 2 / October, 2003 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779135 Sat, 02 Jun 2007 07:42:44 +0100 779135 http://www.medworm.com/index.php?rid=779133&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe07675ll23qp4778%2F Abstract  Botulinum neurotoxin (BoNT) has been called the most poisonous poison and a potential bioterrorism weapon, and yet modern medicine has been able to harvest the elegant and specific activity of this toxin to treat a variety of medical conditions. BoNT application recently has been extended to prostate disorders, and this article reviews the literature on the mechanisms of action and clinical efficacy of BoNT treatment in the prostate. BoNT has demonstrated promising preliminary results for male lower urinary tract symptoms, and translational research suggests novel mechanism of action of BoNT in the prostate. It is important to remember that the application of BoNT in the prostate is not approved by the regulatory agencies and caution should be applied until larger... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779133 Sat, 02 Jun 2007 07:42:33 +0100 779133 http://www.medworm.com/index.php?rid=779142&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv880390gt381280x%2F Abstract  External beam radiation therapy (EBRT) and brachytherapy are common treatment modalities for newly diagnosed prostate cancer. What complications can patients and physicians expect following these therapies? How are these conditions diagnosed and treated? In this article, we examine several of the most common acute and delayed complications of radiation therapy for prostate cancer. In addition, we discuss appropriate follow-up diagnostics for these patients and our suggestions for management of the main complications that may develop. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 4 Journal IssueVolume 4, Number 1 / March, 2006 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779142 Sat, 02 Jun 2007 07:42:15 +0100 779142 http://www.medworm.com/index.php?rid=779136&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4wxq766320476314%2F Abstract  The etiology of chronic nonbacterial chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS) is unclear. That may be why treatment with antibiotics and anti-inflammatory drugs often fail. The use of urodynamic testing in evaluating any patient with both pelvic/perineal pain coexistent with voiding symptoms can help identify voiding dysfunction. If identified, urodynamic voiding disorders, such as bladder neck obstruction and pseudodyssynergia, should be specifically treated to ameliorate symptoms. Through more research of nonbacterial CP/ CPPS, we will be able to further define the successful role of videourodynamics in men with this disease. The etiology of chronic nonbacterial chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS) is unclear. That may b... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779136 Sat, 02 Jun 2007 07:41:57 +0100 779136 http://www.medworm.com/index.php?rid=779143&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk453741x270w7666%2F Abstract  In recent years, we have begun to understand the progressive nature of benign prostatic hyperplasia. By careful analysis of population studies and clinical trials, we can determine the factors most likely to predict progression to one of its most distressing complications, acute urinary retention. Acute urinary retention is a common urologic emergency and causes significant suffering, although rarely has it any serious consequences. Using our knowledge regarding the progression of benign prostatic hyperplasia, new treatment modalities are being assessed for their effectiveness at halting progression and ultimately preventing this distressing condition. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X J... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779143 Sat, 02 Jun 2007 07:41:50 +0100 779143 http://www.medworm.com/index.php?rid=779137&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1152025520157602%2F Abstract  Instruments designed to assess the severity of lower urinary tract symptoms have become a routine component of the diagnostic evaluation of men with benign prostatic hyperplasia (BPH). Several validated tools have been developed to this end, including the International Prostate Symptom Score, which is used most commonly today. Despite attempts to correlate symptom score severity with commonly measured objective parameters of BPH, no clear relationships have been found. The reason for this is likely multifactorial and suggests a complex relationship among subjective and objective variables. However, symptom scores show a good correlation with the patient’s perception of quality of life and degree of bother. This is critical because the decision to treat should be... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779137 Sat, 02 Jun 2007 07:41:09 +0100 779137 http://www.medworm.com/index.php?rid=779144&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx8g71p5q66111467%2F Abstract  Prostatitis is the most common urologie diagnosis made in men younger than 50 years of age. The prevalence of prostatitis has been reported to be 11 % to 16% for the general population. Chronic prostatitis is the most common form of prostatitis, accounting for more than 90% of the cases. The pathophysiology of chronic prostatitis is unknown. Nonsteroidal anti-inflammatory agents, α-blockers, and antibiotics appear to be beneficial in treating patients with chronic prostatitis, but may not produce spectacular cure rates. Patients with prostatitis experience considerable morbidity in terms of quality of life and may remain symptomatic for many years. Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Jour... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779144 Sat, 02 Jun 2007 07:40:35 +0100 779144 http://www.medworm.com/index.php?rid=779141&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv042u78861840630%2F Abstract  Most urologic malignancies are diagnosed initially and managed by urologists. However, better outcomes may be attained by integrating the surgical, medical, and radiologic disciplines. The primary care physician remains an important cornerstone whose talents should not be underestimated in the overall patient management scheme. Additional services such as endocrinology, physical therapy, pain control, hospice, nutrition, biofeedback, and hyperbarics, among others, should be considered in the overall health care team. The organization of the team, including definition of the duties of key personnel and even the physical framework of the clinic, contribute to its success in treating patients with prostate cancer. Pitfalls of the process also are discussed in this ar... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779141 Sat, 02 Jun 2007 07:40:09 +0100 779141 http://www.medworm.com/index.php?rid=779138&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj40472873l410300%2F Abstract  Chronic bacterial prostatitis is the most frequent cause for recurrent urinary tract infection in young and middle-aged men. The selection of an appropriate antimicrobial agent that has optimal pharmacokinetics for urine and prostatic secretion and tissue is important in both entities. Fluoroquinolones possess several pharmacologic characteristics that favor them for treatment of urinary tract infection and prostatitis. The pharmacokinetics of fluoroquinolones and the theoretical background of drug penetration into the prostate is outlined. Analyzing the concentrations of various fluoroquinolones in urine, prostatic and seminal fluid, and in prostatic tissue, it becomes obvious that the fluoroquinolones differ in plasma concentrations and in their concentrations a... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779138 Sat, 02 Jun 2007 07:39:35 +0100 779138 http://www.medworm.com/index.php?rid=779139&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgvr070n5h1521255%2F Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 2 Journal IssueVolume 2, Number 3 / September, 2004 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779139 Sat, 02 Jun 2007 07:39:10 +0100 779139 http://www.medworm.com/index.php?rid=779134&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe417427764718116%2F Abstract  The diagnosis of prostate cancer hinges on the use of systematic ultrasound-guided transrectal needle biopsy. The choice of technique is important, especially for patients with a history of a negative biopsy. Saturation biopsy can be considered for patients at risk of cancer who are willing to accept the side effects and who understand that clinically insignificant cancers can be detected. For patients with previous negative sextant biopsies, expanding the zones sampled and increasing the number of biopsy cores can help detect significant cancers while they are still confined. However, as extended biopsy becomes more commonly performed for initial diagnosis, there likely will be less need for saturation biopsy protocols. Content TypeJournal Article JournalC... Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779134 Sat, 02 Jun 2007 07:38:46 +0100 779134 http://www.medworm.com/index.php?rid=779132&cid=s_35944_17_f&fid=35944&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd168807tm8x2030h%2F Content TypeJournal Article JournalCurrent Prostate ReportsOnline ISSN 1544-1865Print ISSN 1544-225X Journal VolumeVolume 2 Journal IssueVolume 2, Number 1 / March, 2004 (Source: Current Prostate Reports) Current Prostate Reports journals http://www.medworm.com/rss/comments.php?id=779132 Sat, 02 Jun 2007 07:38:33 +0100 779132