Der Nervenarzt via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Der Nervenarzt' source. Wed, 08 Feb 2012 20:43:05 +0100 [Sensitive character : An almost forgotten personality disorder - illustrated by the case Anton Reiser.] http://www.medworm.com/index.php?rid=5664363&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22286387%26dopt%3DAbstract [Sensitive character : An almost forgotten personality disorder - illustrated by the case Anton Reiser.] Nervenarzt. 2012 Jan 29; Authors: Tölle R Abstract In his famous 1918 book "The sensitive relative delusion" Ernst Kretschmer not only described this specific delusional disorder but also the underlying sensitive personality disorder. Until now, relatively little attention has been paid to this part of his work. The incomplete reception is outlined, followed by a description of the symptoms, psychodynamics and course of sensitive personality disorder. The interpretation of "Anton Reiser: a psychological novel" - the autobiographical work by Karl Philipp Moritz in 1785 - is used as an example since it describes Anton Reiser as a sensitive personality. PMID: 22286387 ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5664363 Sun, 29 Jan 2012 05:00:00 +0100 5664363 [Significance of the EEG in the diagnosis of epilepsy.] http://www.medworm.com/index.php?rid=5664365&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278123%26dopt%3DAbstract Authors: Rémi J, Noachtar S Abstract The electroencephalogram (EEG) is a specific diagnostic method for the evaluation of patients with epilepsies. Interictal epileptiform discharges (IED) recorded in the seizure interval have a high association with the clinical diagnosis of epilepsy. IEDs have to be differentiated from normal variants that resemble IEDs. The EEG may help in the localization of the epileptogenic zone and in the syndrome classification, which is important for therapy and prognosis. PMID: 22278123 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5664365 Fri, 27 Jan 2012 05:00:00 +0100 5664365 [Concept for allocation of acute stroke patients : Evaluation of the quality of diagnosis reached by the emergency medical services of Münster.] http://www.medworm.com/index.php?rid=5664364&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278124%26dopt%3DAbstract CONCLUSION: Emergency medical services should be involved in the establishment of admission programs for acute stroke patients to provide the fastest means of transportation to a stroke unit. Coma, symptoms of posterior cerebral circulation and epileptic seizures cause difficulties in ensuring an immediate and correct diagnosis. Sending an emergency doctor to the scene increases diagnostic certainty which is essential to initiate early treatment. PMID: 22278124 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5664364 Fri, 27 Jan 2012 05:00:00 +0100 5664364 [Epilepsy.] http://www.medworm.com/index.php?rid=5664366&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278122%26dopt%3DAbstract Authors: Noachtar S PMID: 22278122 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5664366 Thu, 26 Jan 2012 05:00:00 +0100 5664366 [Status epilepticus.] http://www.medworm.com/index.php?rid=5607466&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22249602%26dopt%3DAbstract Authors: Feddersen B, Trinka E Abstract Status epilepticus (SE) is a medical emergency. For diagnostic purposes EEG is mandatory when motor phenomena are absent or when a single seizure evolves into SE with impaired consciousness. The EEG may show focal or generalized status patterns, which must be distinguished from encephalopathies. Initially benzodiazepines are recommended; lorazepam is the drug of choice. When the SE persists, phenytoin, valproate, levetiracetam, lacosamide, and phenobarbital are administered. The choice depends on the underlying comorbidities. In this phase, only phenytoin is licensed. A generalized tonic-clonic status which is refractory is then treated with anesthetics including midazolam, disoprivan, or thiopental. The goal is to achieve burst suppression i... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5607466 Wed, 18 Jan 2012 05:00:00 +0100 5607466 [Epilepsy surgery.] http://www.medworm.com/index.php?rid=5581226&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22237649%26dopt%3DAbstract Authors: Noachtar S, Rémi J Abstract Epilepsy surgery is an important therapeutic option for patients with epilepsy since one third of all epilepsy patients will still not be become seizure free despite newly developed antiepileptic drugs. Anterior temporal lobe resection is the most common procedure. Extratemporal resections require more complex diagnostics and often invasive evaluation which is not the case in most temporal epilepsy patients due to improved imaging (MRI, PET, SPECT). Electrical stimulation of the anterior thalamus has been available as a treatment option since last year. PMID: 22237649 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5581226 Thu, 12 Jan 2012 05:00:00 +0100 5581226 [Differential diagnosis of epileptic seizures.] http://www.medworm.com/index.php?rid=5581221&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22237650%26dopt%3DAbstract We present the most common differential diagnoses and their differences compared to epileptic seizures. PMID: 22237650 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5581221 Thu, 12 Jan 2012 05:00:00 +0100 5581221 [Thiamine, pyridoxine and cobalamine : From myths to pharmacology and clinical practice.] http://www.medworm.com/index.php?rid=5581230&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22230966%26dopt%3DAbstract [Thiamine, pyridoxine and cobalamine : From myths to pharmacology and clinical practice.] Nervenarzt. 2012 Jan 11; Authors: Jesse S, Ludolph AC Abstract Vitamins are not uncommonly uncritically prescribed by neurologists and other medical professions. The effects of vitamins are, however, often pharmacologically and biochemically well-defined. This offers the opportunity for a rational scientific approach to treatment. In this article the biochemical and pharmacological mode of action of vitamins B1 (thiamine), B6 (pyridoxine) and B12 (cobalamine) will be discussed and modern approaches to the diagnosis and treatment of clinical states of hypervitaminoses (B6) and vitamin deficiencies (B1, B6, and B12) will be presented. PMID: 22230966 [PubMed - as supplied by publisher... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5581230 Wed, 11 Jan 2012 05:00:00 +0100 5581230 [History of treatment of schizophrenic forensic patients prior to admission : A comparison with schizophrenic general psychiatric patients.] http://www.medworm.com/index.php?rid=5569728&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215217%26dopt%3DAbstract CONCLUSIONS: The results provide support for the arrangement of an intensive outpatient aftercare, especially for schizophrenic patients with comorbid substance abuse disorders and previous convictions for violent offences. PMID: 22215217 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569728 Thu, 05 Jan 2012 05:00:00 +0100 5569728 [Cranioplasty after supratentorial decompressive craniectomy : When is the optimal timing.] http://www.medworm.com/index.php?rid=5569727&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215218%26dopt%3DAbstract CONCLUSION: This study found that ultra early cranioplasty by reimplanting the patient's own previously removed and frozen skull bone was a safe and successful strategy. PMID: 22215218 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569727 Thu, 05 Jan 2012 05:00:00 +0100 5569727 [Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids.] http://www.medworm.com/index.php?rid=5569726&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215219%26dopt%3DAbstract Authors: Sczesni KC, Alekseyev A, Schlegel U, Skodda S PMID: 22215219 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569726 Thu, 05 Jan 2012 05:00:00 +0100 5569726 [Schizophrenia: more than just a "disturbance of the integrity of the self"] http://www.medworm.com/index.php?rid=5569725&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215220%26dopt%3DAbstract [Schizophrenia: more than just a "disturbance of the integrity of the self"] Nervenarzt. 2012 Jan 5; Authors: PMID: 22215220 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569725 Thu, 05 Jan 2012 05:00:00 +0100 5569725 [Service structure and cooperation in mental health care.] http://www.medworm.com/index.php?rid=5569724&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215221%26dopt%3DAbstract CONCLUSIONS: Improvements in mental health care are more likely to be achieved through improving cooperation rather than just developing additional services. Starting points for improvements include-beyond the increase of resources for cooperation - the training of medical students and psychiatrists in cooperation practice, reimbursement of cooperation and coordination and the implementation of systematic coordination of service networks. PMID: 22215221 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569724 Thu, 05 Jan 2012 05:00:00 +0100 5569724 [Criminological and psychiatric characteristics of inmates of preventive detention and their impact on the treatability :  ] http://www.medworm.com/index.php?rid=5569723&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215222%26dopt%3DAbstract [Criminological and psychiatric characteristics of inmates of preventive detention and their impact on the treatability :  ] Nervenarzt. 2012 Jan 5; Authors: Gairing SK, de Tribolet-Hardy F, Vohs K, Habermeyer E Abstract With its verdict in May 2011 the German Federal Constitutional Court declared the current law for preventive detention unconstitutional and obliged the legislative bodies to undertake a freedom- and treatment-oriented reform. Psychiatrists and psychotherapists are bound to provide therapeutic concepts. Currently there is a lack of information on the intended clientele. In our study we examined 26 persons serving preventive detention, 32 regular prisoners and 29 non-delinquent probands. The groups were matched according to age and intelligence. We gathered... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569723 Thu, 05 Jan 2012 05:00:00 +0100 5569723 [Obituary for Eberhard Lungershausen (15 March 1931 to 21 June 2011).] http://www.medworm.com/index.php?rid=5569722&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215223%26dopt%3DAbstract Authors: Kornhuber J, Demling J, Becker T PMID: 22215223 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569722 Thu, 05 Jan 2012 05:00:00 +0100 5569722 [Psychiatric aspects of epileptic disorders.] http://www.medworm.com/index.php?rid=5569729&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22212216%26dopt%3DAbstract Authors: Schmitz B Abstract Psychiatric complications are common in people with epilepsy and contribute significantly to the impaired quality of life of patients and relatives. This paper discusses psychosis, depression and psychiatric adverse events of anticonvulsants with a focus on practical issues of diagnosis and treatment. PMID: 22212216 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5569729 Wed, 04 Jan 2012 05:00:00 +0100 5569729 [In Process Citation]. http://www.medworm.com/index.php?rid=5517088&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170396%26dopt%3DAbstract Authors: PMID: 22170396 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5517088 Thu, 01 Dec 2011 05:00:00 +0100 5517088 [Medicolegal assessment of post-traumatic vertigo.] http://www.medworm.com/index.php?rid=5481835&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22124567%26dopt%3DAbstract Authors: Thömke F, Dieterich M Abstract Post-traumatic vertigo refers to a group of different disorders which occur following trauma, mainly closed head injury and whiplash injury of the cervical spine. Aside from headaches, vertigo is the most common symptom in this group of patients. In general, there are two main groups of patients with post-traumatic vertigo: those with documented vestibular dysfunctions and those without. The most common post-traumatic vestibular disorders are benign paroxysmal positioning vertigo, labyrinthine concussion, canal dehiscence and otolithic lesions. Some of these disorders are characterized by spontaneous improvement or recovery over weeks or months and some may also be treated effectively. A number of patients, however, develop phobic postural v... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481835 Wed, 30 Nov 2011 05:00:00 +0100 5481835 [Medicolegal assessment of cerebral ischemia and hemorrhage.] http://www.medworm.com/index.php?rid=5481838&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120102%26dopt%3DAbstract Authors: Schneider R Abstract Cerebral ischemia and hemorrhage are the most frequent cause of invalidity and disability in the elderly, corresponding to the significance of these diseases for social law and expert opinion. The sequelae of media infarcts and extended hemorrhage are obvious and offer little reason for litigation. Conflicts occur in cases of minor deficits and less obvious neuropsychological or psychiatric symptoms, including mental, cognitive, mnestic and executive functions. PMID: 22120102 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481838 Sun, 27 Nov 2011 05:00:00 +0100 5481838 [Neuropathology and etiology of focal epilepsy.] http://www.medworm.com/index.php?rid=5481837&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120103%26dopt%3DAbstract Authors: Blümcke I, Hamer HM Abstract In 2010 the International League against Epilepsy published a new classification of epilepsies. A major advance of this classification system is the acknowledgment of a genetic or pathologic-anatomic basis of epilepsy as important predictors of outcome (cause matters). This applies in particular to structural-metabolic lesions, which were frequently recognized in surgical specimens obtained from patients with drug-resistant focal epilepsy, i.e. hippocampal sclerosis, glioneuronal tumors, focal cortical dysplasias, vascular malformations, ischemia, intracerebral hemorrhage, glial scars or inflammation. A better understanding and classification of the etiopathology as well as the underlying molecular mechanisms will help to anticipate and apprec... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481837 Sun, 27 Nov 2011 05:00:00 +0100 5481837 [Lumbal fusion in spondylolisthesis as an unusual cause of symptomatic vasospasms.] http://www.medworm.com/index.php?rid=5481836&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120104%26dopt%3DAbstract Authors: Straeten V, Philipps J, Salbeck R, Glahn J, Schellinger PD PMID: 22120104 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481836 Sun, 27 Nov 2011 05:00:00 +0100 5481836 [Medicolegal evaluation of traumatic brain injury.] http://www.medworm.com/index.php?rid=5481840&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108810%26dopt%3DAbstract Authors: Wallesch CW, Schmidt R Abstract The present state of medicolegal evaluation of persons with traumatic brain injury is discussed in this contribution. Both the ICD and German jurisdiction see a strict separation between structural and only functional brain damage that can be reliably evaluated through neurological, neuropsychological and neuroradiological means. However, there is evidence mainly from MRI investigations that there can be structural changes that presently cannot be detected in the single case, e.g. anisotropy. Furthermore, the neurological and neuropsychological differentiation of directly traumatic and psychogenic disorders can be difficult and requires expertise. PMID: 22108810 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481840 Thu, 24 Nov 2011 05:00:00 +0100 5481840 [Symptomatic lumbar spinal stenosis : Diagnostic evaluation and therapeutic strategies.] http://www.medworm.com/index.php?rid=5481839&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22108811%26dopt%3DAbstract [Symptomatic lumbar spinal stenosis : Diagnostic evaluation and therapeutic strategies.] Nervenarzt. 2011 Nov 24; Authors: Ewald C, Kalff R Abstract Lumbar spinal stenosis is a common problem in daily routine practice. In the vast majority of cases stenosis is caused by degenerative changes of the lumbar spine with neurogenic claudication being the typical symptom. This is defined as sciatic pain and discomfort which deteriorates during walking and standing, leading to progressive neurological deficits. The diagnostic evaluation is based on the typical history of the patient and the clinical examination followed by magnetic resonance imaging (MRI) and flexion-extension X-ray films as the most sensitive diagnostic tool. When clinical symptoms are mild, conservative treatment... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481839 Thu, 24 Nov 2011 05:00:00 +0100 5481839 [Assessment of whiplash and cervical spine injury.] http://www.medworm.com/index.php?rid=5481842&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22105883%26dopt%3DAbstract Authors: Marx P Abstract Formulating an expert opinion on whiplash injuries requires that consideration be given to biomechanical, orthopedic, neurological, psychiatric and medicolegal aspects. The greatest difficulties are encountered in cases of mild whiplash where patients complain of constant pain without any physical correlative. Diverse assessments and principles for approving a claim are reflected in the fact that the prevalence of chronic spine pain after whiplash injuries (late whiplash syndrome) varies between 16% and 71% in different countries, and the proportion of whiplash injuries involved in petitions for compensation differs greatly across Europe (UK 75%, Germany 47%, Finland 8.5% and France 3% of all personal injuries).Important biomechanical, orthopedic, neurologi... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481842 Wed, 23 Nov 2011 05:00:00 +0100 5481842 [Ischemic stroke patients following intravenous thrombolysis : Outcome in a regional stroke center.] http://www.medworm.com/index.php?rid=5481841&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22105884%26dopt%3DAbstract CONCLUSION: The clinical results of IV thrombolysis in our stroke center are similar to the outcome reported from the registration trials and larger clinical series although we treated off label in more than half of the patients. Even larger studies have since shown that the age limit under 80 years for patients is not reasonable. The eligibility criteria should be adapted to reality at this point. PMID: 22105884 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5481841 Wed, 23 Nov 2011 05:00:00 +0100 5481841 [Cerebral amyloid angiopathy with associated vasculitis.] http://www.medworm.com/index.php?rid=5428796&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22089144%26dopt%3DAbstract Authors: Preuße S, Vogelgesang S, Block F PMID: 22089144 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5428796 Fri, 18 Nov 2011 05:00:00 +0100 5428796 [Neurological psychiatric medicolegal assessment.] http://www.medworm.com/index.php?rid=5428798&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083281%26dopt%3DAbstract Authors: Widder B PMID: 22083281 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5428798 Wed, 16 Nov 2011 05:00:00 +0100 5428798 [Drug treatment of epilepsy.] http://www.medworm.com/index.php?rid=5428797&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083282%26dopt%3DAbstract Authors: Schmidt D, Krämer G Abstract Modern medical treatment of epilepsy renders two out of three newly diagnosed epilepsy patients seizure-free. More than 20 drugs are currently available and even for epilepsy specialists it may not be easy to select the drug which is best suited for the individual patient. Current guidelines recommend drugs with proven efficacy and optimal tolerability that address the individual needs of the patient. Non-enzyme-inducing agents are preferred if possible, to protect the patient from loss of efficacy when taking other medications for life-threatening disorders. In one out of three patients, seizure freedom is currently not possible due to drug-resistance, which requires a prompt diagnostic and therapeutic reevaluation of the epilepsy. PMID: ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5428797 Wed, 16 Nov 2011 05:00:00 +0100 5428797 [Deep brain stimulation - expectations and doubts : A nationwide questionnaire study of patients with Parkinson's disease and their family members.] http://www.medworm.com/index.php?rid=5428800&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22080197%26dopt%3DAbstract CONCLUSIONS: The findings suggest that patients and their relatives organized in support groups indeed possess detailed information regarding DBS. However, for the acceptance of the treatment a timely elucidation about DBS as well as responding to the individual concerns by the consulting physician is essential. PMID: 22080197 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5428800 Sun, 13 Nov 2011 05:00:00 +0100 5428800 [Cannabinoids for symptomatic therapy of multiple sclerosis.] http://www.medworm.com/index.php?rid=5428799&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22080198%26dopt%3DAbstract Authors: Husseini L, Leussink VI, Warnke C, Hartung HP, Kieseier BC Abstract Spasticity represents a common troublesome symptom in patients with multiple sclerosis (MS). Treatment of spasticity remains difficult, which has prompted some patients to self-medicate with and perceive benefits from cannabis. Advances in the understanding of cannabinoid biology support these anecdotal observations. Various clinical reports as well as randomized, double-blind, placebo-controlled studies have now demonstrated clinical efficacy of cannabinoids for the treatment of spasticity in MS patients. Sativex is a 1:1 mix of delta-9-tetrahydocannabinol and cannabidiol extracted from cloned Cannabis sativa chemovars, which recently received a label for treating MS-related spasticity in Germany. The pre... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5428799 Sun, 13 Nov 2011 05:00:00 +0100 5428799 [Prognosis and quality of life after decompressive hemicraniectomy : A nationwide survey in Germany on the attitudes held by doctors and nurses.] http://www.medworm.com/index.php?rid=5428801&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065064%26dopt%3DAbstract CONCLUSIONS: Despite a realistic assessment of prognosis after decompressive hemicraniectomy, a majority of respondents estimated the quality of life of survivors as unsatisfactory. Nurses had a more pessimistic attitude towards decompressive hemicraniectomy. The majority of respondents consider an outcome of 4 on the mRS as unacceptable. PMID: 22065064 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5428801 Wed, 09 Nov 2011 05:00:00 +0100 5428801 [Antipsychotic medications for bipolar I disorders : New atypical neuroleptic drug asenapine approved.] http://www.medworm.com/index.php?rid=5383760&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048568%26dopt%3DAbstract [Antipsychotic medications for bipolar I disorders : New atypical neuroleptic drug asenapine approved.] Nervenarzt. 2011 Nov 4; Authors: Juckel G PMID: 22048568 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383760 Fri, 04 Nov 2011 04:00:00 +0100 5383760 [Advance directives in patients with mental disorders : Scope, prerequisites for validity, and clinical implementation.] http://www.medworm.com/index.php?rid=5383759&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048569%26dopt%3DAbstract This article discusses ethical challenges of advance directives in patients with mental disorders. Besides concrete information on the preferred medical treatment in concrete clinical situations, the mental capacity of the patient at the time of issuing the directive is essential.The "Decisional Competence Assessment Tool for Psychiatric Advance Directives" and empirical studies from the USA on advance directives in patients with mental disorders and the assessment by the treating psychiatrists of these patient directives are discussed. Ethical conclusions are drawn for handling advance directives in psychiatric practice. PMID: 22048569 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383759 Fri, 04 Nov 2011 04:00:00 +0100 5383759 [Mild cognitive impairment in old age : Diagnostics and prognostic significance]. http://www.medworm.com/index.php?rid=5383767&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22033580%26dopt%3DAbstract We present here the concept of mild cognitive impairment (MCI) as the most widely used concept for this stage of dementia processes. Necessary diagnostic procedures for MCI are presented, including clinical, neuropsychological and laboratory methods. Particularly in Alzheimer's disease it seems possible to diagnose a prodromal stage by using biomarkers and brain imaging, i.e. before the clinical dementia syndrome of the Alzheimer's type is present. When diagnosing dementia diseases in the stage of a clinical dementia syndrome, irreversible neuropathological processes are advanced. For this reason we should aim for the clinical detection of dementia disorders in the stage of mild cognitive impairment. This will lead to research on how to slow or even halt the progression of prodromal dement... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383767 Tue, 01 Nov 2011 04:00:00 +0100 5383767 [Personalized psychiatry and psychotherapy : Realistic hope for the future or fiction?]. http://www.medworm.com/index.php?rid=5383765&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038384%26dopt%3DAbstract [Personalized psychiatry and psychotherapy : Realistic hope for the future or fiction?]. Nervenarzt. 2011 Nov;82(11):1382-4 Authors: Falkai P PMID: 22038384 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383765 Tue, 01 Nov 2011 04:00:00 +0100 5383765 [Neuroimaging markers : Their role for differential diagnosis and therapeutic decisions in personalized psychiatry]. http://www.medworm.com/index.php?rid=5383764&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038385%26dopt%3DAbstract This article reports on new neuroimaging markers for the diagnosis of Alzheimer's disease and particularly recent multi-functional magnetic resonance imaging (m-fMRI) studies in patients with schizophrenic and affective psychoses. Using experimental key paradigms for targeted assessment of pathophysiologically relevant neurofunctional systems, these studies reveal both differences and commonalities between the diagnostic categories. In addition, the article outlines research strategies for further development of the classification of major psychoses on the basis of a more precise characterization of the neurofunctional and pathophysiological phenotype. Multivariate approaches may help to identify more complex neuroimaging markers relevant for diagnosis and/or prognosis. Finally, some examp... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383764 Tue, 01 Nov 2011 04:00:00 +0100 5383764 [New options for submission of manuscripts to Der Nervenarzt (The Neurologist)]. http://www.medworm.com/index.php?rid=5383758&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22051967%26dopt%3DAbstract Authors: Maier W, Brandt T, Knapp B PMID: 22051967 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383758 Tue, 01 Nov 2011 04:00:00 +0100 5383758 [Differential indications for psychotherapy exemplified by depression]. http://www.medworm.com/index.php?rid=5383757&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22051968%26dopt%3DAbstract Authors: Schramm E, Berger M Abstract The general efficacy of psychotherapeutic approaches in the treatment of mental disorders has been demonstrated by meta-analyses. Disorder-specific methods are increasingly dominating the field. In the field of depression psychological interventions have proven to be as equally effective as pharmacotherapy in mild and moderate depressives but with longer lasting effects after termination of treatment. The combination of both methods is particularly relevant for the therapy of severe and chronic depression. The indications should be differentiated beyond the severity and course of the disorder, e.g. according to previous traumatization, comorbidity, patient difficulty and the empirical evidence of the different approaches. PMID: 22051968 [Pu... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383757 Tue, 01 Nov 2011 04:00:00 +0100 5383757 [In Process Citation]. http://www.medworm.com/index.php?rid=5383756&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22051969%26dopt%3DAbstract Authors: PMID: 22051969 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383756 Tue, 01 Nov 2011 04:00:00 +0100 5383756 [Therapeutic strategies in stroke aftercare : Contents and effects.] http://www.medworm.com/index.php?rid=5383761&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038388%26dopt%3DAbstract [Therapeutic strategies in stroke aftercare : Contents and effects.] Nervenarzt. 2011 Oct 30; Authors: Steib S, Schupp W Abstract No generally accepted guidelines for stroke aftercare exist in Germany. This literature review summarizes the current evidence regarding the content and the effectiveness of aftercare strategies (exercise therapy, physiotherapy, occupational therapy) and their specific dose (intensity, duration, frequency). Exercise therapy (inter alia physiotherapy, resistance, endurance and gait training) has been shown to be effective for improving physical performance (strength, cardiopulmonary fitness, motor function) resulting in beneficial effects on gait, mobility and activities of daily living (ADL). As for the restoration of ADL and the resumption of so... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383761 Sun, 30 Oct 2011 04:00:00 +0100 5383761 [Interferon α therapy in patients with chronic hepatitis C infection : Biopsychosocial consequences.] http://www.medworm.com/index.php?rid=5383768&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22033579%26dopt%3DAbstract CONCLUSION: Hepatitis C is associated with an increased prevalence of psychiatric disorders, particularly depression. INF-alpha patients having low levels of life satisfaction in the domains "self-concept" (skills, appearance, self-confidence, vitality …), "employment" and "physical health and constitution" seem to face a major risk of depression. PMID: 22033579 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383768 Sat, 29 Oct 2011 04:00:00 +0100 5383768 [Assessment of psychological consequences of trauma.] http://www.medworm.com/index.php?rid=5383766&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038383%26dopt%3DAbstract Authors: Foerster K, Widder B Abstract After accidents psychological consequences are often asserted. This may be due to the traumatic experience itself, the experience of severe physical injury or to the experience of a traumatic hospital treatment. The pivotal point of the medicolegal assessment is the evidence of primary mental or physical damage that has to be documented beyond a reasonable doubt in all areas of law. A medicolegal assessment in five steps is proposed. PMID: 22038383 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383766 Sun, 23 Oct 2011 04:00:00 +0100 5383766 [Multiple sclerosis management system 3D : Moving from documentation towards management of patients.] http://www.medworm.com/index.php?rid=5383763&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038386%26dopt%3DAbstract This article presents the novel computer-based patient management system "multiple sclerosis management system 3D" (MSDS 3D). RESULTS: MSDS 3D allows documentation and visualization of visit schedules and mandatory examinations via defined study modules by integration of data input from patients, attending physicians and MS nurses. It provides forms for the documentation of patient visits as well as clinical and diagnostic findings. Information is collected via interactive touch screens. A specific module which is part of MSDS 3D's current version allows the monthly monitoring of patients under treatment with natalizumab. A checklist covering clinical signs of progressive multifocal leukoencephalopathy (PML) and a detailed questionnaire about the handling ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383763 Thu, 20 Oct 2011 04:00:00 +0100 5383763 [Alemtuzumab: a further option for treatment of multiple sclerosis.] http://www.medworm.com/index.php?rid=5383762&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22038387%26dopt%3DAbstract Authors: Menge T, Kieseier BC, Warnke C, Aktas O, Hartung HP Abstract Alemtuzumab is a humanized monoclonal therapeutic antibody that targets the CD52 antigen which s expressed on most cells of the lymphoid lineage, exclusive of precursors. Alemtuzumab rapidly depletes CD52(+) cells from the peripheral blood. This depletion is long-lasting, and cells repopulate in a specific pattern with B cells and regulatory T cells peaking first. Alemtuzumab was examined for clinical utility in two open-labelled intervention trials in multiple sclerosis (MS). Because of very promising results its clinical efficacy was further explored in a clinical phase-II trial using s.c. interferon beta-1a as the active comparator. Severe or opportunistic infections were surprisingly rare given the long-t... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5383762 Thu, 20 Oct 2011 04:00:00 +0100 5383762 [Cognitive losses in old age, cognitive reserve, structural resistance.] http://www.medworm.com/index.php?rid=5333953&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009137%26dopt%3DAbstract Authors: Janzarik W Abstract Losses of mnestic and other competencies in very old persons are presently being studied from different perspectives, e.g., neurobiological, neuropsychological, and phenomenological ones. In this context the concept of cerebral and cognitive reserve has been formulated. From a personalist perspective the concept of structural resistance should be added, which is based on central dispositions in personality structure and determines the capacity to find ways to navigate through the losses in advanced age, and the dynamics to follow these paths. PMID: 22009137 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5333953 Wed, 19 Oct 2011 04:00:00 +0100 5333953 [Considerations about the efficacy of psychopharmacological drugs.] http://www.medworm.com/index.php?rid=5333954&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22002839%26dopt%3DAbstract Authors: Leucht S, Heres S, Davis JM Abstract Current systematic reviews yielded relatively small efficacy effect sizes of different psychopharmacological agents compared to placebo. It seems that these effect sizes have decreased compared to earlier meta-analyses. We speculate about factors explaining the decrease of effect size such as lower methodological requirements for earlier randomised controlled trials, but in particular enormous methodological problems of current trials such as chronic patient populations, exclusion of severely ill patients by the protocols, sponsoring by the pharmaceutical industry and so-called professional patients. A few examples from general medicine are used to illustrate that the effect sizes of other medications are often also surprisingly small. ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5333954 Sun, 16 Oct 2011 04:00:00 +0100 5333954 [In Process Citation]. http://www.medworm.com/index.php?rid=5319137&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21984645%26dopt%3DAbstract Authors: PMID: 21984645 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5319137 Sat, 01 Oct 2011 04:00:00 +0100 5319137 [Neuropsychology of psychoeducation in schizophrenia : Results of the Munich COGPIP study.] http://www.medworm.com/index.php?rid=5268875&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21953134%26dopt%3DAbstract CONCLUSION: Besides baseline illness knowledge neurocognition was the only significant predictor for illness knowledge after psychoeducation. Patients with cognitive deficits can profit from psychoeducation in the long run as well. In future it should be examined whether a modified cognitive training program could achieve a faster improvement of the illness knowledge. PMID: 21953134 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5268875 Thu, 29 Sep 2011 04:00:00 +0100 5268875 [The development of depression : The role of brain-derived neurotrophic factor.] http://www.medworm.com/index.php?rid=5268876&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947218%26dopt%3DAbstract [The development of depression : The role of brain-derived neurotrophic factor.] Nervenarzt. 2011 Sep 28; Authors: Stuke H, Hellweg R, Bermpohl F Abstract An association between the presence of psychosocial stress, its pathological processing and the development of depression is well documented. This review reports and discusses studies suggesting a reduced release of brain-derived neurotrophic factor (BDNF) under stress as a possible mechanism. The studies show a reduction of BDNF secretion in stressful situations, a decreased blood concentration in depression and a normalization of BDNF by successful antidepressant therapy. As a possible mechanism of BDNF action, a reactivation of neuroplasticity is being discussed, especially in hippocampal and cortical networks. On the ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5268876 Wed, 28 Sep 2011 04:00:00 +0100 5268876 [Pain assessment in patients with dementia.] http://www.medworm.com/index.php?rid=5268878&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21932148%26dopt%3DAbstract Authors: Bornemann-Cimenti H, Wejbora M, Michaeli K, Kern-Pirsch C, Sandner-Kiesling A Abstract Recent literature demonstrates that pain in patients with dementia is often undertreated. This can partially be explained by a lack of training in the possibilities of assessing pain in patients with dementia.Subjective reports are the most valid approach for the assessment of the subjective experience of pain and should therefore be preferred over other methods. The assessment of the context, behavior, and physiological markers is advised if the patient is unable to provide a subjective report. Pain assessment scales are useful for documentation and monitoring. PMID: 21932148 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5268878 Wed, 21 Sep 2011 04:00:00 +0100 5268878 [Microneurovascular facial reanimation via the masseteric nerve : Reconstruction alternative for long-standing facial palsy.] http://www.medworm.com/index.php?rid=5268877&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21932149%26dopt%3DAbstract CONCLUSIONS: Innervation of free muscle flaps with the masseteric nerve for oral commissure reanimation might play an important role in patients with long-standing facial palsy (as in Möbius syndrome). Synkinesis persists for long periods after surgery. However, most of the patients had learned to express their emotions by overcoming this phenomenon. Despite hypercorrection or inadequate correction, patients evaluate themselves favorably. PMID: 21932149 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5268877 Wed, 21 Sep 2011 04:00:00 +0100 5268877 [Sensory neuronopathy of Sjögren's syndrome : A diagnostic challenge.] http://www.medworm.com/index.php?rid=5235694&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21927943%26dopt%3DAbstract We report on four patients in whom biopsy of the salivary gland was helpful in establishing the diagnosis of Sjögren's syndrome and consequently immunosuppressive therapy was initiated. One of these patients suffered from hypersalivation. This was probably due to denervation hypersensitivity. To our knowledge this has not been reported yet. PMID: 21927943 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5235694 Sun, 18 Sep 2011 04:00:00 +0100 5235694 [The future of biomarkers in dementia diagnostics.] http://www.medworm.com/index.php?rid=5235697&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21922304%26dopt%3DAbstract Authors: Zimmermann R, Kornhuber J, Lewczuk P Abstract Neurochemical dementia diagnostics (NDD) is a routine laboratory tool in the diagnostic process of patients with neurodegenerative disorders, such as Alzheimer's disease (AD). Currently, two groups of biomarkers analyzed in the cerebrospinal fluid (CSF) are being considered, namely amyloid β (Aβ) peptides and tau proteins, along with the hyperphosphorylated forms of the latter (p-tau). Current directions in the development of NDD include the following: 1. search for novel biomarkers with improved analytical or diagnostic performance; 2. search for biomarkers in the blood; 3. applications of novel technologies enabling better management of patient samples; 4. optimization of the analysis of the biomarkers already available (fo... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5235697 Sat, 17 Sep 2011 04:00:00 +0100 5235697 [Pedophilia : Prevalence, etiology, and diagnostics.] http://www.medworm.com/index.php?rid=5221937&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21909808%26dopt%3DAbstract Authors: Mokros A, Osterheider M, Nitschke J Abstract Pedophilia is a disorder of sexual preference that increases the risk for committing sexual offenses against children. Consequently, pedophilia is not only relevant in psychiatric therapy and prognostics, but also greatly influences the public attitude towards criminality. Public opinion seems to equate pedophilia with child sexual abuse and vice versa which leads to stigmatization of patients and may impede treatment. The present paper provides information on recent studies on the potential origins of the disorder and introduces new diagnostic methods. Moreover, the article presents estimates on the prevalence of pedophilic sexual interest. PMID: 21909808 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5221937 Sun, 11 Sep 2011 04:00:00 +0100 5221937 [Serum-based biomarkers for psychiatric disorders.] http://www.medworm.com/index.php?rid=5221938&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21909807%26dopt%3DAbstract Authors: Bahn S, Schwarz E Abstract There are many challenges associated with the discovery and development of serum-based biomarkers for psychiatric disorders such as schizophrenia. Here, we review these challenges from the point of view of psychiatrists, the regulatory agencies and biomarker scientists. There is a general opinion in psychiatric medicine that improvements over the current subjective tests are essential. Despite this there is a reluctance to accept that peripheral molecules can do the job any better. In addition, psychiatrists find it difficult to accept that peripheral molecules, such as those found in blood, can reflect what is happening in the brain. However, the regulatory health authorities now consider biomarkers as important for the future of drug developmen... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5221938 Sat, 10 Sep 2011 04:00:00 +0100 5221938 [Acute ischemic stroke : New approaches to antithrombotic treatment.] http://www.medworm.com/index.php?rid=5221939&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901539%26dopt%3DAbstract Authors: Kraft P, Nieswandt B, Stoll G, Kleinschnitz C Abstract The only recommended therapy in the acute phase of ischemic stroke is thrombolysis within 4.5-(6) h after symptom onset. For secondary stroke prevention platelet inhibitors or, in cases of cardiac embolism, anticoagulants are used. However, these substances bear significant limitations: either they show only moderate efficacy (platelet inhibitors), or they are associated with a considerable bleeding risk (rt-PA, anticoagulants). Although the majority of strokes are caused by embolic or thrombotic vessel occlusion, strikingly little is known about the pathophysiological role of platelets and their local function in the brain vasculature. The recent development of novel transgenic mouse lines paved the way for the in-dep... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5221939 Thu, 08 Sep 2011 04:00:00 +0100 5221939 [Unruptured intracranial aneurysms.] http://www.medworm.com/index.php?rid=5221943&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21882058%26dopt%3DAbstract Authors: Steinmetz H Abstract The incidental discovery of an asymptomatic intracranial arterial aneurysm is no longer uncommon. It can change a person's life. Decision-making should be guided by a thorough comparison of the risks associated with the natural course and with microsurgical or endovascular intervention. At present this comparison will favor a conservative approach in the majority of patients, especially in those with small aneurysms or who are over 50 years old. PMID: 21882058 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5221943 Fri, 02 Sep 2011 04:00:00 +0100 5221943 [Cerebral hemiatrophy without serious psychopathological symptoms.] http://www.medworm.com/index.php?rid=5221942&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21882059%26dopt%3DAbstract Authors: Hamel AM, Laux G, Nachbar JS, Paul HW PMID: 21882059 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5221942 Fri, 02 Sep 2011 04:00:00 +0100 5221942 [Quality features of German memory clinics : A cross-sectional study.] http://www.medworm.com/index.php?rid=5221941&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21882060%26dopt%3DAbstract CONCLUSION: The development of homogeneous structure and process standards could help to establish memory clinics in regular care and to establish sustainable funding. In order to achieve this, an even more intensive collaboration and consensus building of all German memory clinics would be needed as well as a coordinated representation of interests. PMID: 21882060 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5221941 Fri, 02 Sep 2011 04:00:00 +0100 5221941 [In Process Citation]. http://www.medworm.com/index.php?rid=5221940&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21898193%26dopt%3DAbstract Authors: PMID: 21898193 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5221940 Thu, 01 Sep 2011 04:00:00 +0100 5221940 [Diagnostic criteria for eating disorders : What will DSM-5 feature?] http://www.medworm.com/index.php?rid=5180561&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879399%26dopt%3DAbstract This article describes the suggested modifications of the diagnostic criteria for eating disorders for the DSM-5. The DSM-5 abstains from setting a specific numerical standard for weight for AN and reduces the required minimum frequency for BN and binge eating disorder (BED) to once a week over the last 3 months. This will likely reduce the number of cases in the EDNOS category. In addition, the DSM-5 provides brief descriptions of several conditions of potential clinical significance without providing detailed criteria in order to stimulate additional research. PMID: 21879399 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5180561 Wed, 31 Aug 2011 23:00:00 +0100 5180561 [Misconduct in therapeutic relationships.] http://www.medworm.com/index.php?rid=5161271&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21861161%26dopt%3DAbstract Authors: PMID: 21861161 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5161271 Tue, 23 Aug 2011 23:00:00 +0100 5161271 [Clinical neurological diagnosis of sepsis-associated delirium.] http://www.medworm.com/index.php?rid=5143814&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21853375%26dopt%3DAbstract Authors: Rosengarten B, Mayer K, Weigand MA Abstract Sepsis is a frequent emergency and an acute disease which is still highly lethal. Due to an early involvement of the brain in terms of a sepsis-associated delirium the neurologist plays an important role in the early diagnosis of the interdisciplinary disease. The following review details the main diagnostic aspects of a sepsis-associated delirium. PMID: 21853375 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143814 Fri, 19 Aug 2011 23:00:00 +0100 5143814 [Eating disorders : New findings for diagnosis and treatment.] http://www.medworm.com/index.php?rid=5143813&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21853376%26dopt%3DAbstract Authors: Herpertz-Dahlmann B, de Zwaan M PMID: 21853376 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143813 Fri, 19 Aug 2011 23:00:00 +0100 5143813 [Karl Jaspers : Tasks and limitations of psychotherapy.] http://www.medworm.com/index.php?rid=5143821&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21845449%26dopt%3DAbstract Authors: Schlimme JE, Paprotny T, Brückner B Abstract Using Jaspers' methodically critical attitude (methodenkritische Einstellung) we distinguish three aspects of his understanding of psychotherapy: (1) psychotherapy gains scientific quality via methodical strictness (and is therefore independent of a therapist's weltanschauung); (2) psychotherapy is a (more or less) 'hermeneutical' method of self-enlightenment, offering limited statements with respect to one's life conduct; and (3) psychotherapy oversteps its epistemological limits if gaining the status of a weltanschauung, instead of leading to (existential) philosophizing in the face of transcendence. Following Jaspers we try to answer the question: What are the limits of psychotherapeutic methods with respect to questions of ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143821 Tue, 16 Aug 2011 23:00:00 +0100 5143821 [Fingolimod treatment for multiple sclerosis patients : Infectiological aspects and recommendations for vaccinations.] http://www.medworm.com/index.php?rid=5143820&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21845450%26dopt%3DAbstract Authors: Winkelmann A, Löbermann M, Reisinger EC, Zettl UK Abstract Since April 2011 fingolimod (FTY 720, Gilenya®), a new oral treatment, is available for relapsing-remitting multiple sclerosis (MS) in Germany. Adverse effects in pre-marketing clinical controlled multicenter studies have led to specific precautions that have to be followed before initiating treatment. According to the European Union prescribing information fingolimod is not to be used as a first-line treatment, but is licensed as a second-line option or escalating therapy of MS. During treatment physical and neurological examinations as well as regular blood counts should be performed. The immunosuppressive mode of action of fingolimod requires increased awareness of infectious complications. Due to two fatal he... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143820 Tue, 16 Aug 2011 23:00:00 +0100 5143820 [Critical illness polyneuropathy und polymyopathy : How certain is the clinical diagnosis in patients with weaning failure?] http://www.medworm.com/index.php?rid=5143819&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21845451%26dopt%3DAbstract Authors: Oehmichen F, Pohl M, Schlosser R, Stogowski D, Toppel D, Mehrholz J Abstract A frequent cause of weaning failure and the resultant long-term artificial ventilation is the generalized weakness syndrome in the sense of critical illness polyneuropathy or polymyopathy. However, hardly any information is presently available regarding the necessary intensity of the diagnostic workup for reaching or excluding a diagnosis with certainty in the neurological examination or regarding the additional diagnostic value of electrophysiological studies in patients receiving long-term acute care suspected of having critical illness polyneuropathy and polymyopathy. Therefore, the goal of this investigation was to address these questions.A total of 280 patients with complicated weaning were i... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143819 Tue, 16 Aug 2011 23:00:00 +0100 5143819 [Arthur Simons on tonic neck reflexes in persons with hemiplegia : From the years 1916 to 1919.] http://www.medworm.com/index.php?rid=5143818&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21845452%26dopt%3DAbstract Authors: Holdorff B Abstract Tonic neck reflexes described in 1921 by Magnus and deKlejn in animals and men were studied in hemiplegic patients who were mainly victims of WWI by Arthur Simons, a neurologist in Berlin and coworker of Hermann Oppenheim. The effect of the asymmetric neck reflexes after head rotation was restricted to the paralyzed side: tonus (spasms) of extension and adduction during mid-position of the head or head version to the paralyzed side; flexion tonus and abduction during head version to the non-paralyzed side; and flexion tonus (spasms) of the paralyzed limbs during flexion of the head and extension spasms by head extension. More than this, hemiplegic "Mitbewegungen" or associated reactions (Walshe) were observed. They are elicited by conscious innervations... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143818 Tue, 16 Aug 2011 23:00:00 +0100 5143818 [Hemorrhagic renal infarction after stroke : Importance of visceral embolisms for the stroke unit.] http://www.medworm.com/index.php?rid=5143823&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21842330%26dopt%3DAbstract Authors: Kazarians H, Rieper J, Arning C PMID: 21842330 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143823 Sat, 13 Aug 2011 23:00:00 +0100 5143823 [Lifestyle and cognition : What do we know from the aging and neurodegenerative brain?] http://www.medworm.com/index.php?rid=5143822&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21842331%26dopt%3DAbstract Authors: Steiner B, Witte V, Flöel A Abstract Epidemiological studies demonstrated positive effects of continuous physical activity and balanced diet on cardiovascular fitness. In chronic neurodegenerative disorders, e.g. Parkinson's disease and Alzheimer's disease, physical activity has become a successful supportive symptomatic therapy. However, it has become evident that physical activity not only improves motor symptoms but also has high impact on cognition in both (elderly) healthy brain and neurodegenerative alterations in the CNS. Nutrition also has been reported to exert positive effects on brain function.Animal studies indicate an increased endogenous plasticity as the underlying mechanism in terms of activation of neuronal precursor cells in different brain areas, leadin... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143822 Sat, 13 Aug 2011 23:00:00 +0100 5143822 [Psychotherapy and obesity : Strategies, challenges and possibilities.] http://www.medworm.com/index.php?rid=5143824&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833770%26dopt%3DAbstract Authors: Teufel M, Becker S, Rieber N, Stephan K, Zipfel S Abstract One fifth of the German population is obese with increasing prevalence. Psychotherapy plays an important role in weight loss programmes. Cognitive behaviour therapy, targeting lifestyle changes, including exercise and eating behaviour, is the evidence-based treatment of choice. Especially the lack of motivation or absence of weight loss, further weight gain or psychosocial burden makes psychotherapy essential. The treatment of a comorbid binge eating disorder should be initiated prior to focusing on weight loss. Remarkably difficult stages in the treatment of obesity are the initiation of changes as well as the maintenance of the achieved weight loss. Internet-based attempts will become increasingly important. ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5143824 Wed, 10 Aug 2011 23:00:00 +0100 5143824 [Treatment of bulimia nervosa.] http://www.medworm.com/index.php?rid=5118509&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21818607%26dopt%3DAbstract This article summarizes the treatment options and their respective evidence for bulimia nervosa. Apart from the choice of treatment setting, psychotherapeutic treatment measures and the role of psychopharmacologic drugs for the treatment of bulimia nervosa are discussed. PMID: 21818607 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5118509 Fri, 05 Aug 2011 23:00:00 +0100 5118509 [German Consortium for Frontotemporal Lobar Degeneration.] http://www.medworm.com/index.php?rid=5118510&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21805118%26dopt%3DAbstract Authors: Otto M, Ludolph AC, Landwehrmeyer B, Förstl H, Diehl-Schmid J, Neumann M, Kretzschmar HA, Schroeter M, Kornhuber J, Danek A, Frontotemporal lobar degeneration (FTLD) is an umbrella term for an aetiologically diverse group of neurodegenerative disorders with prominent lobar cortical atrophy. First this disease group was restricted to Pick's disease or Pick's complex. Several updates of the clinical classification systems were performed and discussed. Currently we summarize the following diseases under the FTLD spectrum: frontotemporal dementia (FTD) as a behavioural variant, primary non-fluent aphasia (PNFA) and semantic dementia as language variants, amyotrophic lateral sclerosis with FTD (ALS-FTD), corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP).From th... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5118510 Sat, 30 Jul 2011 23:00:00 +0100 5118510 [Advanced therapy strategies in neurological diseases : Present and perspectives.] http://www.medworm.com/index.php?rid=5118511&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21796437%26dopt%3DAbstract Authors: Ludolph AC, Kassubek J PMID: 21796437 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5118511 Thu, 28 Jul 2011 23:00:00 +0100 5118511 [New developments in epileptogenesis and therapeutic perspectives.] http://www.medworm.com/index.php?rid=5071063&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21789691%26dopt%3DAbstract Authors: Lerche H, Vezzani A, Beck H, Blümcke I, Weber Y, Elger C Epileptogenesis describes the mechanisms of how epilepsies are generated. We have chosen four areas in which significant progress has been achieved in understanding epileptogenesis. Those are (1) inflammatory processes which play an increasingly important role for the generation of temporal lobe epilepsy with hippocampal sclerosis (TLE with HS), (2) disturbances of intrinsic properties of neuronal compartments, in particular acquired defects of ion channels of which those in dendrites are described here for TLE with HS, (3) epigenetic effects, which affect for example the methylation of promoters and secondarily can change the expression of specific genes in TLE with HS, and finally (4) the epileptogenesis of idiopathic... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071063 Tue, 26 Jul 2011 23:00:00 +0100 5071063 [Difficult decisions in stroke therapy.] http://www.medworm.com/index.php?rid=5071062&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21789692%26dopt%3DAbstract In this report the authors address some of the difficult treatment decisions encountered in acute therapy and secondary prevention. Examples include off-label thrombolysis and prevention in high-risk situations. The available data from trials and registries are discussed, and personal views and recommendations are expressed. PMID: 21789692 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071062 Tue, 26 Jul 2011 23:00:00 +0100 5071062 [The presymptomatic stage of neurodegenerative disorders.] http://www.medworm.com/index.php?rid=5071061&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21789693%26dopt%3DAbstract Authors: Klein C, Hagenah J, Landwehrmeyer B, Münte T, Klockgether T Neurodegenerative disorders, such as Huntington's disease, spinocerebellar ataxias, Parkinson's disease or Alzheimer's disease, manifest in adult age with insidiously developing, slowly progressing symptoms. At this stage, most patients consult a doctor, and a definite diagnosis can be made. It is, however, well established that the manifest disease is preceded by a presymptomatic disease stage that may last for years. A striking example is Parkinson's disease, in which more than half of the dopaminergic neurons of the substantia nigra are lost before motor symptoms appear. Studies of the presymptomatic stage of neurodegenerative disorders are pivotal for an advanced understanding of these disorders and the developme... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071061 Tue, 26 Jul 2011 23:00:00 +0100 5071061 [Deep brain stimulation for psychiatric disorders : Historical basis.] http://www.medworm.com/index.php?rid=5071066&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21761184%26dopt%3DAbstract Authors: Huys D, Möller MV, Kim EH, Hardenacke K, Huff W, Klosterkötter J, Timmermann L, Woopen C, Kuhn J Deep brain stimulation (DBS), which is already established as an effective treatment for movement disorders, such as Parkinson's disease, is increasingly being considered as a therapy option for mental diseases. Due to the increasing number of successful applications of DBS for otherwise therapy-resistant psychiatric diseases, DBS is becoming more and more of interest in fields of fundamental research as well as clinical care. However, the stimulation system is a medical product which has to be neurosurgically implanted and this fact is often used to draw certain analogies to earlier psychosurgical approaches in the era of Freeman. But, looking at the historical development of DB... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071066 Wed, 20 Jul 2011 23:00:00 +0100 5071066 [Antibody-associated diseases of the gray matter of the CNS : Diagnosis and treatment.] http://www.medworm.com/index.php?rid=5071064&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21773672%26dopt%3DAbstract Authors: Bien CG In the past 10 years, the diagnosis and understanding of immune-mediated diseases of the gray matter of the CNS have greatly advanced with the discovery of autoantibodies in serum and CSF of affected patients. The newly described antibodies against neuronal surface antigens, i.e., receptors, channels, and associated proteins, seem to have a direct pathogenic effect on CNS neurons. Fortunately, there is a beneficial effect of immunotherapy in many patients. The diagnosis of autoantibody-associated disease of the CNS gray matter requires the combination of a typical clinical syndrome or a characteristic paraclinical finding (MRI, CSF, histopathology) with the detection of a specific antibody. In the following, an overview will first be given of the syndromes typically a... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071064 Wed, 20 Jul 2011 23:00:00 +0100 5071064 [Silent brain infarcts.] http://www.medworm.com/index.php?rid=5071067&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21761183%26dopt%3DAbstract Authors: Ritter MA, Dittrich R, Ringelstein EB Silent brain infarctions are frequently found by modern cerebral imaging. Up to 30% of persons without a clinical history of stroke were found to have silent brain infarction in epidemiological studies. "Silent" refers to ischemic brain lesions for which no matching clinical syndrome can be found based on history or clinical investigation. Age, education, and ethnic background have a strong impact on noticing and reporting stroke symptoms. The current clinical definition of stroke is insensitive for cognitive deficits which can also be caused by brain infarctions. The majority of silent brain infarctions are localized in the subcortical white matter of the brain; however, about 10% of silent brain infarctions are cortical. Silent brain inf... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071067 Fri, 15 Jul 2011 23:00:00 +0100 5071067 [Neuroprotection in the treatment of multiple sclerosis.] http://www.medworm.com/index.php?rid=5071065&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21761185%26dopt%3DAbstract Authors: Zipp F, Gold R Atrophy, the wasting or shrinkage of tissue, of the nervous system is the main feature of neurodegeneration, i.e. the umbrella term for the progressive loss of structure or function of neurons. Loss of neurons due to cell death and axonal degeneration characterize neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease or amyotrophic lateral sclerosis. In these illnesses, it still has to be elucidated to which extent inflammation is part of the pathology. Conversely, in chronic inflammation of the central nervous system (CNS), atrophy has previously also been described and neurodegeneration is discussed as a pathologic feature. The most frequent chronic inflammatory disease of the CNS is multiple sclerosis (MS), which leads to devastating rel... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071065 Fri, 15 Jul 2011 23:00:00 +0100 5071065 [Anorexia nervosa in childhood and adolescence : Course and significance for adulthood.] http://www.medworm.com/index.php?rid=5071069&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21755335%26dopt%3DAbstract Authors: Herpertz-Dahlmann B, Bühren K, Seitz J The estimated prevalence of anorexia nervosa is highest in teenagers and probably increasing in prepubertal girls, while morbidity rates in female adults remain constant. Childhood and adolescent AN often take a chronic and disabling course with severe consequences for somatic and mental health in adulthood and an eventually high mortality. Besides a reduced growth, diminished reproduction rate and an increased risk of osteoporosis a prolonged course of the disorder may impact on the development of the adolescent brain, probably by hormonal dysfunctions such as those of the corticoid and gonadal system and by severe changes in neuropeptides such as leptin. Thus, besides a genetic disposition, longer lasting effects of starvation on brain... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071069 Thu, 14 Jul 2011 23:00:00 +0100 5071069 [Internet-based approaches in the therapy of eating disorders.] http://www.medworm.com/index.php?rid=5071068&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21755336%26dopt%3DAbstract Authors: Fichter MM, Quadflieg N, Nisslmüller K, Lindner S, Vorderholzer U, Wünsch-Leiteritz W, Osen B, Huber T, Zahn S, Meermann R, Irrgang V, Bleichner F Recent technological developments of communication media offer new approaches to diagnostic and therapeutic interactions with patients. One major development is Internet-based primary prevention in vulnerable individuals not yet suffering as well as the development of new therapeutic approaches for affected individuals based on the experiences of guided self-help through CD, DVD or bibliotherapy. The eating disorder literature shows several interesting, partly controlled and randomized, studies on bulimia nervosa, a few studies on binge eating disorder and no studies on anorexia nervosa. As part of the German Eating Disorder Netwo... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071068 Thu, 14 Jul 2011 23:00:00 +0100 5071068 [Eating disorders associated with obesity and diabetes.] http://www.medworm.com/index.php?rid=5071070&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21750949%26dopt%3DAbstract Authors: Munsch S, Herpertz S Binge eating disorder is one of the most frequent comorbid mental disorders associated with overweight and obesity. Binge eating disorder patients often suffer from other mental disorders and longitudinal studies indicate a continuous weight gain during the long-term course. As in other eating disorders gender is a risk factor, but the proportion of male binge eating disorder patients is surprisingly high.In young women with type 1 diabetes the prevalence of subclinical types of bulimia nervosa is increased. In addition, insulin purging as a characteristic compensatory behavior in young diabetic women poses a considerable problem. In patients with type 1 diabetes, disturbed eating and eating disorders are characterized by insufficient metabolic control and... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5071070 Wed, 13 Jul 2011 23:00:00 +0100 5071070 [Consequences of the German Federal Guardianship Law after Reunification (1992-2009).] http://www.medworm.com/index.php?rid=5023581&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21744178%26dopt%3DAbstract DISCUSSION: In spite of the legal changes in the direction of a dynamic instrument in mental health care, the practise of the Legal Guardianship Law indicates a continuous increase of guardianship orders since 1992. It is necessary to recognise that a slowdown of the upward trend is not in sight. Therefore it is pertinent to call those persons in charge of regulating legal guardianship to consider their daily practise carefully. On the other hand it is a task of mental health services research to analyse the driving factors of the presented developments. PMID: 21744178 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5023581 Sat, 09 Jul 2011 23:00:00 +0100 5023581 [Giant cell arteritis with motor involvement of the upper trunk.] http://www.medworm.com/index.php?rid=5023583&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21739272%26dopt%3DAbstract Authors: Klein M, Rosenkranz T, Vierbuchen M, Terborg C PMID: 21739272 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5023583 Fri, 08 Jul 2011 23:00:00 +0100 5023583 [Muscular dystrophy due to mutations in anoctamin 5 : Clinical and molecular genetic findings.] http://www.medworm.com/index.php?rid=5023582&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21739273%26dopt%3DAbstract We report five German patients (four index patients) with muscle dystrophy due to mutations in the ANO5 gene. Sequencing of the ANO5 exons 5, 13 and 20 was performed to screen for a common c.191dupA mutation and two other reported mutations (c.1295C>G and p.R758C). The whole coding region of the ANO5 gene was sequenced to identify new mutations. Phenotypically, three patients showed LGMD and one patient Miyoshi type distal myopathy. One sibling had asymptomatic hyperCKemia. The age at onset was 64, 38 and 40 years in patients with LGMD and 23 years in the patient with distal myopathy. The four symptomatic patients showed remarkable asymmetric muscle involvement. There was marked CK elevation (11 to 30 times). Electron microscopy showed multifocal gaps in the sarcolemmal membrane. All pa... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5023582 Fri, 08 Jul 2011 23:00:00 +0100 5023582 [Mobile biosensor-based gait analysis : A diagnostic and therapeutic tool in Parkinson's disease.] http://www.medworm.com/index.php?rid=5023580&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21748456%26dopt%3DAbstract This study investigated a mobile biosensor-based gait analysis system for patients in early and intermediate stages of PD compared to controls. Subjects wearing a motion sensor-equipped shoe performed a standardized gait exercise. Accelerometer- and gyroscope-based signals were analysed using a complex set of pattern recognition algorithms. The analysis was able (1) to distinguish between PD patients and controls, (2) to identify patients at an early stage of the disease and (3) to distinguish between early and intermediate stage patients. Thus, using this mobile biosensor-based analysis system we were able to obtain objective classifications of gait characteristics in PD. Future studies will show that mobile biosensor-based movement detection technology will support identification of earl... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5023580 Tue, 05 Jul 2011 23:00:00 +0100 5023580 [State-dependent motivational interviewing for people with schizophrenia and substance use : Results of a randomised controlled trial.] http://www.medworm.com/index.php?rid=5023585&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720841%26dopt%3DAbstract CONCLUSION: The study design allows one for the first time to attribute the findings to the specific effects of MI and thereby emphasizes the effectiveness of this particular treatment approach. In summary, these findings show that the integration of short-term MI for people with both psychosis and substance abuse could significantly improve their chances of attending appropriate outpatient settings and thereby improve their well-being. PMID: 21720841 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5023585 Fri, 01 Jul 2011 23:00:00 +0100 5023585 --- http://www.medworm.com/index.php?rid=5023584&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21725722%26dopt%3DAbstract Nervenarzt. 2011 Jul;82(7):932-936 Authors: PMID: 21725722 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5023584 Thu, 30 Jun 2011 23:00:00 +0100 5023584 [Structural and functional neuronal connectivity in Alzheimer's disease : A combined DTI and fMRI study.] http://www.medworm.com/index.php?rid=5023586&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21713583%26dopt%3DAbstract CONCLUSION: Our data suggest that under healthy conditions, effective connectivity in the DMN between posterior cingulate cortex and hippocampus is mainly maintained by the indirect pathway via the parahippocampal gyrus. Patients with AD and patients with MCI show changes in this connectivity with a partial allocation to the direct pathway, most likely reflecting early parahippocampal lesions. The combination of DTI and fMRI broadens our understanding of human brain connectivity and its pathological changes with AD. PMID: 21713583 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=5023586 Wed, 29 Jun 2011 23:00:00 +0100 5023586 [Immunoadsorption for steroid-unresponsive multiple sclerosis-relapses : Clinical data of 14 patients.] http://www.medworm.com/index.php?rid=4974543&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21667161%26dopt%3DAbstract CONCLUSION: Immunoadsorption for the treatment of steroid-unresponsive MS relapses was safe and effective. The response rate was comparable to published results with PE. With IA, in contrast to unselective PE, administration of human plasma products is not necessary, avoiding associated risks. PMID: 21667161 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4974543 Sat, 11 Jun 2011 23:00:00 +0100 4974543 [Static posturography in selected Parkinson syndromes : Quantitative analysis of postural control.] http://www.medworm.com/index.php?rid=4925320&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21660610%26dopt%3DAbstract CONCLUSION: Static posturography may be a helpful tool for the differentiation of Parkinson syndromes. PMID: 21660610 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925320 Fri, 10 Jun 2011 23:00:00 +0100 4925320 [Risk stratification of progressive multifocal leukoencephalopathy under natalizumab : Recommendations for JC virus serology.] http://www.medworm.com/index.php?rid=4925321&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21656322%26dopt%3DAbstract Authors: Warnke C, Adams O, Hartung HP, Gold R, Hemmer B, Hohlfeld R, Stangel M, Zipp F, Wiendl H, Kieseier BC JC virus (JCV)-associated progressive multifocal leukoencephalopathy (PML) represents a rare but serious side effect of natalizumab (Tysabri®) in the treatment of patients with relapsing forms of multiple sclerosis (MS). Two factors that may increase the risk of PML have been identified: treatment duration beyond 24 months and prior immunosuppressive therapy. Recently determination of anti-JCV antibodies mirroring JCV infection has allowed a third factor to be added to this list, and a positive serological test has been included as a risk factor on the label of natalizumab. Clearly, JCV serology represents a tool for PML risk stratification in MS patients treated with natali... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925321 Thu, 09 Jun 2011 23:00:00 +0100 4925321 [Pregabalin and gabapentin in multiple sclerosis : Clinical experiences and therapeutic implications.] http://www.medworm.com/index.php?rid=4925323&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647743%26dopt%3DAbstract CONCLUSION: So far, it is not known whether the investigated agents exert a beneficial influence on the disease course of MS itself beyond a mere symptomatic treatment. Further research efforts and clinical studies are necessary to address this question. PMID: 21647743 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925323 Tue, 07 Jun 2011 23:00:00 +0100 4925323 [Hirayama disease in Germany : Case reports and review of the literature.] http://www.medworm.com/index.php?rid=4925322&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647744%26dopt%3DAbstract Authors: Kang JS, Jochem-Gawehn S, Laufs H, Ferbert A, Vieregge P, Ziemann U Hirayama disease is a juvenile benign distal upper limb muscular atrophy rarely observed in Europe, usually monomelic involving C7-Th1 innervated muscles. It is characterized by insidious onset and a self-limited course within a few years. The pathogenesis of this mostly sporadic disease is not fully clarified. Cervical flexion myelopathy with mechanical ischemic damage of spinal motoneurons is the best established pathogenetic hypothesis, but neurodegenerative and autoimmune causes are also debated. Typically, young men of Asian origin are affected. Here we describe three German Caucasian patients with Hirayama disease and provide an up-to-date review of the literature. PMID: 21647744 [PubMed - as supplie... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925322 Tue, 07 Jun 2011 23:00:00 +0100 4925322 [Use of joint crisis plans in psychiatric hospitals in Germany : Results of a nationwide survey.] http://www.medworm.com/index.php?rid=4925324&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21633830%26dopt%3DAbstract CONCLUSIONS: A theoretical offer of joint crisis plans is widespread in German psychiatric hospitals. Despite positive experiences, patients do not ask for them frequently. PMID: 21633830 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925324 Thu, 02 Jun 2011 23:00:00 +0100 4925324 [Motor neuron diseases.] http://www.medworm.com/index.php?rid=4925327&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626001%26dopt%3DAbstract Authors: Petri S, Meyer T Motor neuron diseases (MND) are a group of neurodegenerative disorders which are present in clinical, prognostic and genetic diversity. The most common MND are amyotrophic lateral sclerosis (ALS), proximal spinal muscular atrophy (SMA) and various forms of hereditary and sporadic lower motor neuron syndromes including hereditary motor neuropathies (HMN). Familial and "sporadic" forms of ALS and lower motor neuron syndromes are known. The essential pathogenic findings in MND have emerged from molecular biological examinations of the hereditary forms of MND. In ALS, one consistent neuropathological feature is intraneuronal protein inclusions which arise from TDP-43, FUS, SOD1 or ataxin-2 aggregations. TDP-43, FUS, SOD1 and ataxin-2 are multifunctional DNA/RNA-bi... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925327 Tue, 31 May 2011 23:00:00 +0100 4925327 [Hypothermia under olanzapine treatment : Clinical case series and review of current literature.] http://www.medworm.com/index.php?rid=4925326&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626387%26dopt%3DAbstract CONCLUSION: A review of the current literature reveals that thermoregulatory disturbances as sequelae of antipsychotic drug administration depend on individual disposition as well as various independent risk factors such as environmental temperature, somatic comorbidities, endocrinological abnormalities (e.g. hypothyroidism) and structural damage of the brain. A complex interaction of dopaminergic regulatory mechanisms in the ventral hypothalamus and peripheral vaso- and sudomotor adjustments seems to be causative. Hypothermia following antipsychotic drug administration represents a serious adverse drug reaction and a potentially life-threatening event. PMID: 21626387 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925326 Tue, 31 May 2011 23:00:00 +0100 4925326 [Socio-medical aspects of mental disorders : Mental disorders in the German medical health care system and socio-medical therapeutic interventions.] http://www.medworm.com/index.php?rid=4925325&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626388%26dopt%3DAbstract Authors: Muschalla B, Linden M In the first article social medicine was defined. In this second article the health care system and special socio-medical treatments for the individual are described. The role of social medicine is to describe and optimize the health care system. The legal basis for the structure of the health care system is the Social Law. The individual encounter between therapists and patients is also regulated by law. This includes a contract of personal service. Liability of therapists is therefore restricted to correct treatment, which must be documented, and not depending on outcome. Therapists must cooperate with each other. There are special socio-medical treatments for individuals. This includes sickness certificates, enforced treatment, guardianship, support by... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925325 Tue, 31 May 2011 23:00:00 +0100 4925325 [Neuromuscular diseases.] http://www.medworm.com/index.php?rid=4925319&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21660611%26dopt%3DAbstract Authors: Schoser B, Zierz S PMID: 21660611 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925319 Tue, 31 May 2011 23:00:00 +0100 4925319 --- http://www.medworm.com/index.php?rid=4925318&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21660612%26dopt%3DAbstract Nervenarzt. 2011 Jun;82(6):767 Authors: Diedler J, Sykora M, Herweh C, Orakcioglu B, Zweckberger K, Steiner T, Hacke W PMID: 21660612 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4925318 Tue, 31 May 2011 23:00:00 +0100 4925318 [Standard treatment for myositis and muscular dystrophies.] http://www.medworm.com/index.php?rid=4878808&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21614632%26dopt%3DAbstract Authors: Schmidt J, Vorgerd M We summarize the current therapeutic strategies and options in inflammatory myositis and the muscular dystrophies. In myositis, the therapeutic options include basic therapy with glucocorticosteroids and other standard immunosuppressive agents, and in individual cases escalating treatment with chemotherapy or monoclonal antibodies. The exact therapeutic sequence should be performed depending on the type of myositis and the response to immunosuppression.At present, there are still no effective causative interventions to significantly alter the progression of the muscular dystrophies. However, first gene therapy clinical studies have been started in some forms of muscular dystrophy which may open a new field of therapeutic options.Most patients with myositis... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4878808 Thu, 26 May 2011 23:00:00 +0100 4878808 [Socio-medical aspects of mental disorders : Definition, epidemiology, context and assessment of capacity.] http://www.medworm.com/index.php?rid=4878810&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21594630%26dopt%3DAbstract Authors: Muschalla B, Linden M Social medicine is an interdisciplinary field of medicine which analyses and describes the interactions between illness, individual, society, and organisational structures of the health care system, including prevention, treatment and rehabilitation. Part of social medicine is epidemiology, including analytic epidemiology. The goal is to monitor the prevalence and spectrum of illnesses in the general population or subpopulations and to study possible risks of illness. The question is which environmental or contextual factors influence the prevalence and course of illnesses. Another area of social medicine is to evaluate patients and decide who needs social support. Important topics are inability to work, need for early retirement and pension, or disabilit... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4878810 Wed, 18 May 2011 23:00:00 +0100 4878810 [Default mode network of the brain : Neurobiology and clinical significance.] http://www.medworm.com/index.php?rid=4878812&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21584789%26dopt%3DAbstract Authors: Otti A, Gündel H, Wohlschläger A, Zimmer C, Sorg C, Noll-Hussong M The resting state of the human brain is intrinsically organized by the so-called default mode network (DMN) which comprises cortical midline structure as well as lateral parietal and temporal areas. The activity of this system increases during self-oriented thinking, e.g. during a resting state but decreases during externally oriented attention and specific cognitive tasks. This review article provides a historical and methodological outline of the DMN model and describes its functional anatomy and putative functions. Based on the empirical literature the clinical implications of alterations of the DMN architecture and its role in various mental disorders are discussed. PMID: 21584789 [PubMed - as supplie... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4878812 Tue, 17 May 2011 23:00:00 +0100 4878812 [Neuromuscular signal transmission in adulthood : Current facets of acquired and hereditary disorders.] http://www.medworm.com/index.php?rid=4878811&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21584790%26dopt%3DAbstract Authors: Abicht A, Kröger S, Schoser B The availability of early diagnosis and modern effective therapies has reduced mortality and disability linked to late-onset acquired or hereditary neuromuscular transmission disorders. Nevertheless, identification of the pathogenesis of these diseases remains a challenge. In addition to non-specific and fluctuating presenting symptoms current diagnostic work-up strategies include electrophysiology, antibody measurements and less frequently molecular genetics. For differential diagnostic purposes there is an increasing demand for improving awareness concerning late-onset congenital myasthenic syndromes (CMS) which are rare but nevertheless symptomatically treatable diseases. Especially in seronegative myasthenic syndromes, molecular genetic analy... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4878811 Tue, 17 May 2011 23:00:00 +0100 4878811 [Responsible dealing with sexuality : Recommendations in a clinical institution.] http://www.medworm.com/index.php?rid=4878809&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21607802%26dopt%3DAbstract Authors: Steinberg R, Rittner C, Dormann S, Spengler-Katerndahl D Sexuality is excluded in house regulations, guidelines, instructions and regulations in German hospitals. The English literature does not show much more, but more often the wish for clear guidelines is formulated. Under the guidance of the clinical Ethics Committee a paper with recommendations was prepared, which comprises regulations for responsible handling of sexuality in the Pfalzklinikum. This includes sexuality of acute patients in psychiatry, nursing home inhabitants, forensic patients and above all patients in the department of child and youth psychiatry. The right of self-realization on the one hand, the staff's responsibility for patients with limitations in the determination of one's intent on the other hand a... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4878809 Sat, 14 May 2011 23:00:00 +0100 4878809 [Treatment of neuro-AIDS on a neurological intensive care unit : Epidemiology and predictors of outcome.] http://www.medworm.com/index.php?rid=4827555&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21567297%26dopt%3DAbstract DISCUSSION: The rate of death during treatment of neuro-AIDS on a neurological intensive care unit is much higher than during treatment of internal medicine problems of HIV infection. Antiretroviral naïve immigrants show a much higher rate of death compared to residents in Germany. A lot of research and effort is necessary to improve the availability of the Highly Active Anti-Retroviral Therapy (HAART) worldwide in order to improve the outcome especially for immigrants with neuro-AIDS treated on a neurological intensive care unit. PMID: 21567297 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827555 Fri, 13 May 2011 23:00:00 +0100 4827555 [Facioscapulohumeral muscular dystrophy : Clinical picture, atypical forms, diagnostics, genetics.] http://www.medworm.com/index.php?rid=4827554&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21567298%26dopt%3DAbstract Authors: Jordan B, Müller-Reible C, Zierz S The classic phenotype of the facioscapulohumeral muscular dystrophy (FSHD) includes an initially restricted pattern of asymmetric weakness of facial and shoulder girdle muscles. Disease progression is usually slow and typically accompanied by foot extensor muscle weakness and pelvic girdle weakness. Atypical patterns of FSHD that include isolated camptocormia and facial muscle sparing exceed current diagnostic criteria.No causal genetic lesion in FSHD has been identified yet. In the vast majority of cases, FSHD results from a heterozygous partial deletion of a critical number of repetitive elements (D4Z4) on chromosome 4q35 (4qA allele). Molecular diagnostic testing is appropriate to confirm the diagnosis of FSHD without need for muscle biop... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827554 Fri, 13 May 2011 23:00:00 +0100 4827554 [Posthypoxic locked-in syndrome.] http://www.medworm.com/index.php?rid=4827557&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21562907%26dopt%3DAbstract Authors: Hansen HC PMID: 21562907 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827557 Thu, 12 May 2011 23:00:00 +0100 4827557 [Mirtazapine and hyperemesis gravidarum.] http://www.medworm.com/index.php?rid=4827556&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21562908%26dopt%3DAbstract Authors: Lieb M, Palm U, Jacoby D, Baghai TC, Severus E The case of a 29-year-old patient in the 21st gestational week with severe hyperemesis gravidarum which did not respond to conventional antiemetic treatment is reported. Nausea and vomiting improved within 48 h after i.v. administration of 30 mg mirtazapine/day. The pathophysiological and therapeutic implications are discussed. PMID: 21562908 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827556 Thu, 12 May 2011 23:00:00 +0100 4827556 [Update Stroke Conference 2011 : International Stroke Conference 2011, Los Angeles, USA.] http://www.medworm.com/index.php?rid=4827558&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21544684%26dopt%3DAbstract Authors: Ebinger M, Endres M PMID: 21544684 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827558 Thu, 05 May 2011 23:00:00 +0100 4827558 [Psychiatry as a cultural science : considerations according to Max Weber.] http://www.medworm.com/index.php?rid=4827561&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528418%26dopt%3DAbstract Authors: PMID: 21528418 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827561 Fri, 29 Apr 2011 23:00:00 +0100 4827561 [Was the expert medical opinion rendered by B. von Gudden regarding King Ludwig II of Bavaria correct?] http://www.medworm.com/index.php?rid=4827560&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528419%26dopt%3DAbstract We report on the results of a 5-year research project conducted at the Heidelberg Academy of Sciences and Humanities and based on information derived from private and public archives in Germany and abroad. Reference is made to comparable analyses. Neither von Gudden's expertise nor Ludwig's behaviour provide reliable cues to his alleged insanity. The reasons and motives behind the king's deposition are discussed. Apart from von Gudden's tragic death, this was not a singular case of a psychiatric expertise commissioned in the monarchist culture of the nineteenth and the early twentieth century. PMID: 21528419 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827560 Fri, 29 Apr 2011 23:00:00 +0100 4827560 [Brain imaging in autism spectrum disorders : A review.] http://www.medworm.com/index.php?rid=4827559&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21533594%26dopt%3DAbstract This article summarizes pertinent functional brain imaging studies addressing the neuronal underpinnings of ASD symptomatology (impairments in social interaction and communication, repetitive and restrictive behavior) and associated neuropsychological deficits (theory of mind, executive functions, central coherence), complemented by relevant structural imaging findings. The results of these studies show that although cognitive functions in ASD are generally mediated by the same brain regions as in typically developed individuals, the degree and especially the patterns of brain activation often differ. Therefore, a hypothesis of aberrant network connectivity has increasingly been favored over one of focal brain dysfunction. PMID: 21533594 [PubMed - as supplied by publisher] (Source: Der... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827559 Thu, 28 Apr 2011 23:00:00 +0100 4827559 [Bernhard von Gudden on the occasion of the 125th anniversary of his death.] http://www.medworm.com/index.php?rid=4827564&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21523441%26dopt%3DAbstract Authors: Steinberg R, Hippius H Bernhard von Gudden died 125 years ago together with King Ludwig II of Bavaria, his royal patient. The prominence of the "Fairy Tale King", the circumstances surrounding the deprivation of his power and his psychiatric internment as well as the establishment of Luitpold's reign and above all the catastrophic ending of the Bavarian royal drama still outshine Gudden's importance for the scientific development of the new subject of Nervenheilkunde (psychiatry and neurology), particularly Bernhard von Gudden's importance and integrity as a physician. Not only was he a much sought-after academic teacher, but he was also a patient-focused advocate of the principle of no restraint. As director of mental institutions, Gudden gave vital impulses for the improveme... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827564 Wed, 27 Apr 2011 23:00:00 +0100 4827564 [Psychobiosocial interventions for autism.] http://www.medworm.com/index.php?rid=4827563&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21523442%26dopt%3DAbstract This article provides a brief summary of the premises and principles of successful psychobiosocial ASD intervention. ABA, TEACCH, PECS, social skills and cognitive training are described as examples for established approaches to ASD. Training of μ-suppression using neurofeedback and reanimation of the fusiform gyrus and amygdala using computer-aided facial affect recognition training are introduced as neurobiologically based ASD interventions. PMID: 21523442 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827563 Wed, 27 Apr 2011 23:00:00 +0100 4827563 [Dementia and depression determine care dependency in Parkinson's disease : Analysis of 1,449 outpatients receiving nursing care in Germany.] http://www.medworm.com/index.php?rid=4827562&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21523443%26dopt%3DAbstract CONCLUSION: The risk for CD is substantially elevated in outpatients with PD when further neuropsychiatric symptoms are present. The data suggest that depression contributes equally to disability as does dementia. PMID: 21523443 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827562 Wed, 27 Apr 2011 23:00:00 +0100 4827562 [Sexual disorders from the perspective of the neurologist.] http://www.medworm.com/index.php?rid=4827565&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21509611%26dopt%3DAbstract Authors: Vodušek DB The temporal lobes and other cortical regions are involved in the emotional, cognitive and sensorimotor aspects of central control of sexual behaviour, whereas the insula, anterior cingulate and hypothalamus coordinate the activation of the autonomic nervous system. Facilitatory and inhibitory descending pathways modify the activity of thoracolumbar sympathetic and sacral parasympathetic and somatic spinal centres which control the sexual response, i.e. arousal, orgasm and ejaculation. A normal hormonal milieu and vascular system, but also a healthy psychosocial context, are necessary for a fulfilled sexual life. Sexual dysfunction is not uncommon in the general population, particularly in the elderly; it is more common in neurological patients. It significantly lo... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827565 Thu, 21 Apr 2011 23:00:00 +0100 4827565 [Vanishing white matter disease : A stress-related leukodystrophy.] http://www.medworm.com/index.php?rid=4827567&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21503715%26dopt%3DAbstract Authors: Prange H, Weber T PMID: 21503715 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827567 Tue, 19 Apr 2011 23:00:00 +0100 4827567 [Autism spectrum disorders.] http://www.medworm.com/index.php?rid=4827566&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21503716%26dopt%3DAbstract Authors: Meyer-Lindenberg A PMID: 21503716 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4827566 Sat, 16 Apr 2011 23:00:00 +0100 4827566 [Autism and ADHD across the life span : Differential diagnoses or comorbidity?] http://www.medworm.com/index.php?rid=4723079&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21484168%26dopt%3DAbstract Authors: Banaschewski T, Poustka L, Holtmann M Exclusion criteria of the DSM-IV-TR and ICD-10 do prevent dual diagnoses of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). However, inattention, impulsivity and hyperactivity are amongst the most frequent associated symptoms of ASD. Psychopathological, neuropsychological, brain imaging and genetic studies suggest possible pathophysiological links between ASD and ADHD. Thus, standard diagnostic procedures for both disorders should assess the presence of potential comorbid symptoms of the other disorder. Treatment strategies for ADHD symptoms in the context of ASD overlap with those for patients with ADHD, but lower dosages and slower titration might be recommendable. PMID: 21484168 [PubMed - as supp... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723079 Tue, 12 Apr 2011 23:00:00 +0100 4723079 [Psychopharmacology of autism spectrum disorders.] http://www.medworm.com/index.php?rid=4723078&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21484169%26dopt%3DAbstract Authors: Poustka L, Banaschewski T, Poustka F Autism spectrum disorders (ASD) are persistent, heterogeneous conditions that display many comorbid problems. Especially maladaptive behaviours like increased irritability, aggression, impulsivity and self-injurious behaviours are perceived as enormously stressful and can interfere with interventions targeting social and communication deficits. Medication treatments focussing on troubling comorbid problems in ASD can be fundamentally ameliorative, although core features of the disorder itself cannot be sufficiently treated. While atypical antipsychotics and stimulant medication have been proven to be effective in large multisite networks of ASD, serotonin reuptake inhibitors are of limited efficacy. Novel pharmacotherapies to improve social... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723078 Tue, 12 Apr 2011 23:00:00 +0100 4723078 [Is there evidence that depression screening benefits patients with medical illness? : Not yet.] http://www.medworm.com/index.php?rid=4723081&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21479739%26dopt%3DAbstract Authors: Thombs BD, Körner A Depression is increasingly recognized as a common and disabling condition, and improving depression care has been prioritized by policy-makers in Germany and elsewhere. Screening for depression, which refers to the routine use of depression screening tools or sets of questions to identify patients who may have depression, but whose depression is otherwise not recognized by their physician, is one solution that has been proposed. However, there has never been a clinical trial that has found better depression outcomes for patients screened for depression compared to patients not screened when the same treatment and care resources are made available to both groups. There are, on the other hand, many negative trials that have failed to find benefit to patients... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723081 Sat, 09 Apr 2011 23:00:00 +0100 4723081 [Susac syndrome : An interdisciplinary challenge.] http://www.medworm.com/index.php?rid=4723080&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21479740%26dopt%3DAbstract Authors: Dörr J, Jarius S, Wildemann B, Ringelstein EB, Schwindt W, Deppe M, Wandinger KP, Promesberger J, Paul F, Kleffner I Susac syndrome, named after John Susac, the first to describe this condition, is characterized by the clinical triad of encephalopathy, branch retinal artery occlusion, and sensorineural hearing loss. Although certainly a rare disease, Susac syndrome needs to be considered in the differential diagnosis of a broad variety of diseases. The pathogenesis is not yet clear. Autoimmune processes leading to damage and inflammation-related occlusion of the microvessels in brain, retina, and inner ear are thought to play a causal role. The diagnosis is based primarily on the clinical presentation, the documentation of branch retinal artery occlusion by fluorescence angio... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723080 Sat, 09 Apr 2011 23:00:00 +0100 4723080 [MusiQol: international questionnaire investigating quality of life in multiple sclerosis : Validation results for the German subpopulation in an international comparison.] http://www.medworm.com/index.php?rid=4723083&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21472450%26dopt%3DAbstract CONCLUSION: The results of this study confirm the validity and reliability of MusiQoL as an instrument for measuring the quality of life of German and international MS patients. PMID: 21472450 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723083 Thu, 07 Apr 2011 23:00:00 +0100 4723083 [Genetics and animal modeling of autism spectrum disorders : New developments.] http://www.medworm.com/index.php?rid=4723082&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21472451%26dopt%3DAbstract Authors: Klauck SM, Poustka L, Chiocchetti A Autism spectrum disorders (ASD) are pervasive developmental disorders with a complex phenotype in respect to communication, verbal development, and social behavior. Manifold molecular genetic analyses point towards a multifactorial genetic predisposition. For the identification of central key mechanisms large consortia have performed linkage analysis, genome-wide association, and copy number variation (CNV) studies, which led to the characterization of risk factors for ASD like CNV and single nucleotide polymorphisms but also single rare mutations. The so far associated genomic regions and candidate genes impact neuronal development especially the establishment of the synaptic cleft, secretion of surface proteins, or dendritic translation. T... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723082 Wed, 06 Apr 2011 23:00:00 +0100 4723082 [Muscle channelopathies : Myotonias and periodic paralyses.] http://www.medworm.com/index.php?rid=4723077&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21484581%26dopt%3DAbstract Authors: Jurkat-Rott K, Lerche H, Lehmann-Horn F The myotonias and familial periodic paralyses are muscle channelopathies. They have in common an impaired muscle excitation that is caused by mutations in voltage-gated Na(+), K(+), Ca(2+), and Cl(-) channels. Membrane hyperexcitability usually results in myotonic stiffness; with increasing membrane depolarization hyperexcitability can be transiently turned into hypoexcitability causing transient weakness as in severe myotonia. Hypoexcitability due to long-lasting depolarization that inhibits action potential generation is the common mechanism for the periodic paralyses. Interictally, the ion channel malfunction may be compensated, so that specific exogenous or endogenous provocative factors are required to produce symptoms in the patien... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723077 Thu, 31 Mar 2011 23:00:00 +0100 4723077 --- http://www.medworm.com/index.php?rid=4723076&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21484582%26dopt%3DAbstract Nervenarzt. 2011 Apr;82(4):522-529 Authors: PMID: 21484582 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4723076 Thu, 31 Mar 2011 23:00:00 +0100 4723076 [Intensive medical care of patients with intracerebral hemorrhaging.] http://www.medworm.com/index.php?rid=4669422&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21431439%26dopt%3DAbstract Authors: Diedler J, Sykora M, Herweh C, Orakcioglu B, Zweckberger K, Steiner T, Hacke W Approximately 10-15% of acute strokes are caused by non-aneurysmatic intracerebral hemorrhage (ICH) and incidences are expected to increase due to an aging population. Studies from the 1990s estimated mortality of ICH to be as high as 50%. However, these figures may partly be attributed to the fact that patients suffering from ICH frequently received only supportive therapy and the poor prognosis may therefore be more a self-fulfilling prophecy. Recently it has been shown that treatment in a specialized neurological intensive care unit alone was associated with better outcomes after ICH. In recent years considerable efforts have been undertaken in order to develop new therapies for ICH and to assess... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4669422 Wed, 23 Mar 2011 00:00:00 +0100 4669422 [Heterogeneity and comorbidity of obsessive-compulsive disorder.] http://www.medworm.com/index.php?rid=4549992&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21347693%26dopt%3DAbstract Authors: Zaudig M Although the DSM-IV-TR suggests that obsessive-compulsive disorder (OCD) is a coherent syndrome, scientific evidence offers a compelling case that OCD is highly heterogeneous and possibly composed of many different subtypes. OCD can display completely distinct symptom patterns thus making it difficult to identify a single "textbook" profile of OCD. The present state of research concerning subtyping is presented. There is a high comorbidity with depression and anxiety disorders, but all together data concerning OCD comorbidity are still not convincing. Currently obsessive-compulsive spectrum disorders (OCS) are described as a set of disorders lying on a continuum from compulsive to impulsive, with the unifying feature being an inability to regulate behaviour as a conse... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4549992 Thu, 24 Feb 2011 00:00:00 +0100 4549992 [Psychotherapy for obsessive-compulsive disorder : What is evidence based?] http://www.medworm.com/index.php?rid=4549991&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21347694%26dopt%3DAbstract Authors: Külz AK, Voderholzer U Obsessive-compulsive disorder is a severe, very disabling condition that usually takes a chronic course if no adequate treatment is applied. Up to now, cognitive behavioural therapy with exposure and response prevention (CBT) is the most thoroughly investigated and most effective intervention, leading to a clinically significant symptom reduction in 60-70% of the patients. Correctly applied, this treatment can be equally effective as its combination with pharmacological management. For a correct implementation, however, several points have to be considered which are described in the following review. Considering the fact that some of the patients are unable to benefit sufficiently from this approach, potential alternatives and extensions of CBT are disc... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4549991 Thu, 24 Feb 2011 00:00:00 +0100 4549991 [Critical illness myopathy and neuropathy (CRIMYN) : Electroneurographic classification.] http://www.medworm.com/index.php?rid=4549996&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21340635%26dopt%3DAbstract CONCLUSION: A total of four different clusters of electrophysiological impairment can be identified in patients with sepsis/SIRS, which enables further differentiation of the severity of neuromuscular disturbances in sepsis-associated organ failure. This might be useful as a prognostic parameter and can be correlated with additional clinical and paraclinical parameters related to sepsis. PMID: 21340635 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4549996 Wed, 23 Feb 2011 00:00:00 +0100 4549996 [Evidence-based pharmacotherapy and other somatic treatment approaches for obsessive-compulsive disorder : State of the art.] http://www.medworm.com/index.php?rid=4549995&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21340636%26dopt%3DAbstract Authors: Kordon A, Zurowski B, Wahl K, Hohagen F Meta-analyses of the randomized controlled trials (RCT) in obsessive-compulsive disorder (OCD) have clearly demonstrated that selective serotonin reuptake inhibitors (SSRIs) are the medication treatment of choice, while cognitive behavioural therapy (CBT) with exposure and response prevention is the psychotherapy of choice in OCD. Several guidelines emphasized that SSRIs are the first choice of medication in OCD. It has been noted that these agents may need to be given at a higher dose, and for a longer duration, than is usually the case in disorders such as depression. In the management of refractory patients, medication history should be carefully reviewed and adherence to the recommendations of the guideline established. Antipsychotic... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4549995 Wed, 23 Feb 2011 00:00:00 +0100 4549995 [Obsessive-compulsive disorder: psychosocial consequences and quality of life : A review.] http://www.medworm.com/index.php?rid=4549994&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21340637%26dopt%3DAbstract Authors: Hauschildt M, Moritz S The considerable restrictions and psychosocial consequences associated with obsessive-compulsive disorder (OCD) are often multiform and expansive. The subjective distress perceived by individuals with OCD is influenced by multidimensional and interindividually varying factors beyond symptom severity. Therefore, besides symptom scales, generic (general) and illness-specific measures of quality of life (QoL) represent important markers of well-being. The repeatedly described serious consequences of OCD in social, functional, and emotional fields, which often persist even after treatment, refer to the necessity to increasingly address these aspects in treatment planning. Interventions would be desirable which directly involve the patient's social environmen... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4549994 Wed, 23 Feb 2011 00:00:00 +0100 4549994 [Epidemiology and health care situation of obsessive-compulsive disorders.] http://www.medworm.com/index.php?rid=4549993&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21340638%26dopt%3DAbstract Authors: Voderholzer U, Schlegl S, Külz AK Obsessive-compulsive disorders are with a 12-month prevalence of up to 1% and a lifetime prevalence of 1-2% among the more common mental disorders. This is, however, neither reflected in the health care utilization of patients nor in the daily practice of psychotherapists, where obsessive-compulsive disorders still do not seem to play a major role. Due to feelings of shame, patients often tend to conceal their obsessive-compulsive symptoms. Furthermore, besides deficits in the health care situation for this disorder, treatment practice is not satisfying as well. Current guidelines recommend exposure and response prevention as the psychotherapeutic intervention of choice. Although this treatment has proved to be effective, it is still underuti... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4549993 Wed, 23 Feb 2011 00:00:00 +0100 4549993 [Huntington's chorea mimicking adult attention deficit hyperactivity disorder.] http://www.medworm.com/index.php?rid=4494909&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21308357%26dopt%3DAbstract Authors: Kraemer M, Haertig S, Hill A, Uekermann J, Wiltfang J, Kis B PMID: 21308357 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494909 Fri, 11 Feb 2011 00:00:00 +0100 4494909 [Comprehensive stroke unit.] http://www.medworm.com/index.php?rid=4494898&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21308358%26dopt%3DAbstract Authors: Ringelstein EB, Müller-Jensen A, Nabavi DG, Grotemeyer KH, Busse O The concept of a "comprehensive stroke unit" (in German: Erweiterte Stroke-Unit) is an additional structural option for those stroke units already certified in Germany. Its aim is to complement the semi-intensive management of stroke unit patients in Germany by early mobilisation and neuropsychological rehab procedures. This concept is recommended in many European countries as well. It is based on the proof of efficacy of the combined treatment package in several randomised controlled trials. According to the Helsingborg Declaration, every stroke patient in Europe should have access to a chain of care best provided by a comprehensive stroke unit. Both early mobilisation and rehabilitation treatment can be inte... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494898 Fri, 11 Feb 2011 00:00:00 +0100 4494898 [Psychiatric disorders associated with imminent deportation : Results of a retrospective study in a group of immigrants.] http://www.medworm.com/index.php?rid=4494961&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21301800%26dopt%3DAbstract CONCLUSION: Psychoreactive disorders appeared more frequently in immigrant inpatients facing imminent deportation. Additionally a history of traumatisations is associated with the progression of psychoreactive disorders. PMID: 21301800 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494961 Wed, 09 Feb 2011 00:00:00 +0100 4494961 [On the differential diagnostics of depersonalization experiences.] http://www.medworm.com/index.php?rid=4494954&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21301801%26dopt%3DAbstract Authors: Bürgy M Depersonalization represents an unspecific symptom which is to be found across the entire spectrum of psychiatric nosology. Delineating the historical lines of development of the depersonalization concept and reviewing existing psychopathological experiential knowledge reveals that depersonalization is underpinned by highly diverse modes of experience. In terms of differential diagnostics at the symptom level, a distinction can be made between depersonalization as a neurotic phenomenon on the one hand and a psychotic form occurring in schizophrenia and melancholia on the other. The reference points defined here extend beyond current descriptive classifications and open up the diagnostic process to allow an inclusion of etiological and therapeutic aspects. PMID: 21... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494954 Wed, 09 Feb 2011 00:00:00 +0100 4494954 [Forced sterilisation based on the Law for the Prevention of Hereditarily Diseased Offspring : The role of the Heil- und Pflegeanstalt (State Hospital) Günzburg.] http://www.medworm.com/index.php?rid=4494947&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21305259%26dopt%3DAbstract CONCLUSIONS: The study was able to show the active involvement of the Heil- und Pflegeanstalt (State Hospital) Günzburg in the compulsory sterilisation programme. PMID: 21305259 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494947 Wed, 09 Feb 2011 00:00:00 +0100 4494947 [Training in iterative hypothesis testing as part of psychiatric education : A randomized study.] http://www.medworm.com/index.php?rid=4494941&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21305260%26dopt%3DAbstract CONCLUSIONS: Our results point to the role of IHT in teaching diagnostic skills. However, the results of the MC exam were not influenced by IHT training. Furthermore, our results show that students are in need of training in practical clinical skills. PMID: 21305260 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494941 Wed, 09 Feb 2011 00:00:00 +0100 4494941 [Epidemiology and psychopathology of persons running amok : Initial results of an analysis of criminal acts perpetrated by 27 persons running amok.] http://www.medworm.com/index.php?rid=4494932&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21305261%26dopt%3DAbstract Authors: Peter E, Bogerts B In order to clarify psychosocial and psychopathological components that may contribute to causes of running amok, judgements and forensic-psychiatric certificates of 27 amok runners were examined.While in the last 20 years there was no increase of amok events in general, a remarkable increase in so-called school shootings occurred; 74% of the culprits had a history of psychiatric disorder, most importantly schizophrenic psychoses, affective disorder or alcoholism. According to the forensic psychiatric certificates, 70% were not or not fully responsible for the crime.Three prototypes of amok runners were found: (1) adolescents with long-term difficulties at school or apprenticeship and suicidal ideas; (2) persons suffering from paranoid psychoses; and (3) ad... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494932 Wed, 09 Feb 2011 00:00:00 +0100 4494932 [Survey of attention deficit hyperactivity disorder in adults.] http://www.medworm.com/index.php?rid=4494920&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21305262%26dopt%3DAbstract Authors: Hausotter W Attention deficit hyperactivity disorder (ADHD) represents a serious illness which involves impairments in childhood and adolescence that are of considerable importance for the process of social adaptation and thus the development of social competence. If left untreated this leads in a high percentage of cases to disturbances which seriously affect all areas of life reaching into adulthood. Hence, it makes sense and is necessary that adequate treatment is carried out preferably during childhood and adolescence and also at an adult age. Due to the persistence of the disorder in adults with ADHS, various problems arise in formulating expert opinions in conjunction with criminal, social and civil law, in road traffic law and within the scope of conscription. They resu... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494920 Wed, 09 Feb 2011 00:00:00 +0100 4494920 [New oral anticoagulants in atrial fibrillation.] http://www.medworm.com/index.php?rid=4494979&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21286676%26dopt%3DAbstract Authors: Veltkamp R, Hacke W Atrial fibrillation (AF) causes at least 20% of all ischemic strokes. In large randomized trials of primary and secondary stroke prevention, anticoagulation with vitamin K antagonists (VKA) protected much more efficiently than antiplatelet agents against stroke. Because of the problematic pharmacological properties of VKA only part of the AF patients are currently being treated with oral anticoagulants (OAK). The targeted development of specific oral inhibitors of the central coagulation factors thrombin and factor Xa allows reliable anticoagulation without regular coagulation monitoring. In the present review, pharmacological properties of the different agents are compared. Of the four large randomized phase 3 studies in AF (RELY, ROCKET-AF, ARISTOTLE, EN... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494979 Wed, 02 Feb 2011 00:00:00 +0100 4494979 [Development of mortality and morbidity of vascular diseases : Variations between coronary heart disease and stroke.] http://www.medworm.com/index.php?rid=4494973&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21286677%26dopt%3DAbstract CONCLUSION: Despite the substantial knowledge on cardiovascular diseases in Germany a continuous and timely documentation of their determinants, time trends of risk factors and impact regarding mortality and morbidity is compulsory to assess the effectiveness of initiated population health measures and to identify future options for improving prevention and treatment of cardiovascular diseases in Germany. PMID: 21286677 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=4494973 Wed, 02 Feb 2011 00:00:00 +0100 4494973