MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Der Nervenarzt' source. Wed, 17 Mar 2010 14:51:19 +0100 http://www.medworm.com/index.php?rid=3359394&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20221743%26dopt%3DAbstract Authors: Dressing H, Meyer-Lindenberg A Although instances of amok are very rare, they have captured media and political attention following several occurrences in German schools. Mental health professionals are increasingly faced with threat assessment in order to help prevent such tragedies. Since the base rate of amok is low and current risk assessment lacks empirical foundations, the likelihood of false-positive results is high. The role of mental health professionals in this domain should be reframed. The focus should not be risk assessment but risk management since most of the mass murderers are in need of some type of psychiatric intervention prior to the massacre. In contrast, compulsory admission and involuntary treatment are only justified if the threats occur in the context ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3359394 Thu, 11 Mar 2010 00:00:00 +0100 3359394 http://www.medworm.com/index.php?rid=3359395&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20221742%26dopt%3DAbstract Authors: Grimmer T, Drzezga A, Kurz A Imaging techniques for in vivo visualization of cerebral amyloid using positron emission tomography (PET) have been tested in clinical trails over the past 5 years. Based on a selected overview of the literature including our own studies the various radiopharmaceuticals are presented and the current status of research on the validity of amyloid PET imaging as well as its suitability for early and differential diagnosis of Alzheimer's disease (AD) are described.The findings available up to now support the validity of amyloid PET imaging and suggest a possible benefit in differential diagnosis. However, there are as yet no studies with large sample sizes. The possible use for the early diagnosis of AD should be viewed critically, particularly due to ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3359395 Wed, 10 Mar 2010 00:00:00 +0100 3359395 http://www.medworm.com/index.php?rid=3343125&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20204579%26dopt%3DAbstract Authors: PMID: 20204579 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3343125 Mon, 01 Mar 2010 00:00:00 +0100 3343125 http://www.medworm.com/index.php?rid=3323340&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20195565%26dopt%3DAbstract Authors: Hahn K, Husstedt IW, Human immunodeficiency virus (HIV)-associated polyneuropathy has become the most common neurological complication of HIV infection and is one of the main risk factors for development of a neuropathy worldwide. Therefore HIV should always be considered as an underlying cause in patients with neuropathy. Many types of peripheral neuropathies are seen in HIV infection depending on the stage of infection. The inflammatory demyelinating neuropathies both acute (Guillain-Barré syndrome, GBS) and chronic (chronic inflammatory demyelinating neuropathy, CIDP) occur mainly at the time of seroconversion or early in the course of the disease while syndromes associated with opportunistic infections like CMV (i.e. polyradiculoneuropathy) occur in the late phase of... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3323340 Sun, 28 Feb 2010 00:00:00 +0100 3323340 http://www.medworm.com/index.php?rid=3323339&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20195566%26dopt%3DAbstract Authors: Pfueller U, Roesch-Ely D, Mundt C, Weisbrod M Cognitive dysfunction is a core feature of schizophrenia. Although cognitive deficits in the domains of attention, memory and executive functions have been described for many decades, the focus on therapeutic approaches is new. The recognition that cognitive deficits are the best known predictor of functional outcome in schizophrenic patients explains the increasing interest in the diagnosis and therapy of these impairments.Standards for the reliable evaluation of neurocognitive deficits in schizophrenia have been put forward by the MATRICS initiative (Measurement and Treatment Research to Improve Cognition in Schizophrenia).In German-speaking countries the most popular cognitive training programs for schizophrenic patients are "Co... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3323339 Sun, 28 Feb 2010 00:00:00 +0100 3323339 http://www.medworm.com/index.php?rid=3323338&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20195567%26dopt%3DAbstract The objective of this article is to present a detailed review of the literature on strategies for the pharmacological treatment of cognitive deficits. It is not clear whether first-generation antipsychotics have a genuine positive influence on cognition. There is only sparse evidence for the positive effect of second-generation antipsychotics on cognitive processes. Furthermore it is not evident that second-generation antipsychotics are more beneficial than first-generation antipsychotics in the treatment of cognitive deficits. The add-on use of substances which directly influence cognitive processes, so-called cognition-enhancing drugs is more promising. PMID: 20195567 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3323338 Sun, 28 Feb 2010 00:00:00 +0100 3323338 http://www.medworm.com/index.php?rid=3314782&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20182856%26dopt%3DAbstract Authors: Gaul C, Holle D, Sandor PS, Evers S, Broessner G, Straube A, Diener HC Often without sufficient scientific evidence, unconventional methods for migraine treatment are being put forward. Recently a trial using "migraine surgery" has been published. Its design is based on a concept of migraine pathogenesis without any scientific background and includes several severe methodological flaws. In spite of the above, the study is frequently cited in the lay press. The surgical procedure as well as the study are critically discussed. PMID: 20182856 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3314782 Fri, 26 Feb 2010 00:00:00 +0100 3314782 http://www.medworm.com/index.php?rid=3314781&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20182857%26dopt%3DAbstract CONCLUSION: Sleep disturbance is a comorbid risk factor influencing abstinence during smoking cessation. In depressive patients the complex relationship between affect, sleep, nicotine consumption and its withdrawal should be carefully monitored. In such subgroups of smokers willing to quit this has to be taken care of in therapeutic interventions. PMID: 20182857 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3314781 Fri, 26 Feb 2010 00:00:00 +0100 3314781 http://www.medworm.com/index.php?rid=3307316&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20177655%26dopt%3DAbstract Authors: Laufs U, Hoppe UC, Rosenkranz S, Kirchhof P, Böhm M, Diener HC, Endres M, Grond M, Hacke W, Meinertz T, Ringelstein EB, Röther J, Dichgans M PMID: 20177655 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3307316 Wed, 24 Feb 2010 00:00:00 +0100 3307316 http://www.medworm.com/index.php?rid=3292275&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20162411%26dopt%3DAbstract Authors: Ruchsow M, Hermle L, Kober M Great efforts have been made in recent years to use functional magnetic resonance imaging (fMRI) in the context of lie detection. In the present paper the pros and cons of such an approach are analyzed and critically discussed.Both epistemological and methodical considerations have shown that all attempts to derive mental states from fMRI findings ("reverse inference") are not valid. Consequently, fMRI scans cannot reveal a person's thoughts and whether (s)he is lying or telling the truth. PMID: 20162411 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3292275 Thu, 18 Feb 2010 00:00:00 +0100 3292275 http://www.medworm.com/index.php?rid=3240336&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20127230%26dopt%3DAbstract Authors: Hartung HP, Kieseier BC, Aktas O Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system in which autoreactive CD4(+) and CD8(+) T lymphocytes, B lymphocytes, macrophages, antibodies, and cytokines attack the myelin sheaths and damage the axons. The basic therapeutic agents and disease-modifying drugs that are currently available for MS require regular and frequent parenteral administration and therefore long-term compliance is unsatisfactory. Among all of the new oral MS agents presently under development, cladribine is the only substance that appears able to achieve long treatment-free intervals after only short-term administration. Cladribine is an immunomodulator with a long-lasting effect and a well-characterized safety profile based on... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3240336 Wed, 03 Feb 2010 00:00:00 +0100 3240336 http://www.medworm.com/index.php?rid=3232405&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20119654%26dopt%3DAbstract CONCLUSION: Specific phobias in intellectual disability can be treated with behavior therapy as well. However, the special needs of these people need to be considered. PMID: 20119654 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3232405 Sun, 31 Jan 2010 00:00:00 +0100 3232405 http://www.medworm.com/index.php?rid=3232404&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20119655%26dopt%3DAbstract CONCLUSIONS: This study reveals a significant reduction of LOS during the years after introduction of the G-DRG. However, reduction of LOS was not associated with more severe outcome on discharge, possibly due to changes in stroke treatment implemented during the observational period. Our results do not support the conjecture that changes in the reimbursement system were associated with compromised patient care. PMID: 20119655 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3232404 Sun, 31 Jan 2010 00:00:00 +0100 3232404 http://www.medworm.com/index.php?rid=3232403&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20119656%26dopt%3DAbstract Authors: Prüß H, Dalmau J, Arolt V, Wandinger KP Anti-NMDA-receptor encephalitis is a severe and considerably underdiagnosed form of encephalitis with characteristic clinical features including psychiatric symptoms, decreased levels of consciousness, hypoventilation, epileptic seizures, autonomic dysfunction and dyskinesias. Most patients are primarily seen by psychiatrists, often on the assumption of a drug-induced psychosis. Anti-NMDA-receptor encephalitis had initially been described in young women with ovarian teratoma, but is also common in women without tumour, in men and in children. The diagnosis is based on the characteristic clinical picture, supporting findings of brain MRI, electroencephalogram and cerebrospinal fluid (CSF), and the presence of highly specific aut... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3232403 Sun, 31 Jan 2010 00:00:00 +0100 3232403 http://www.medworm.com/index.php?rid=3232402&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20119657%26dopt%3DAbstract Authors: Eikelmann B Day hospitals provide an organizational framework for complex psychiatric and psychotherapeutic treatments. They have been developed regarding treatment and in number, perhaps surprisingly, to fit existing standards in almost all domains of psychiatry. Similarities exist in the emphasis on acute treatment, in the orientation towards social inclusion, and particularly in the ability to connect with previous treatment settings. Day treatment guidelines exist only in basic form. In general the complex outpatient treatment is led by psychiatrists; the treatment is planned and pre-defined regarding time and goal orientation. It is directed exclusively at patients with severe mental health disorders and practiced by a multi-professional team. A structured treatment milie... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3232402 Sun, 31 Jan 2010 00:00:00 +0100 3232402 http://www.medworm.com/index.php?rid=3232401&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20119658%26dopt%3DAbstract Authors: Hacke W, Meyding-Lamadé U PMID: 20119658 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3232401 Sun, 31 Jan 2010 00:00:00 +0100 3232401 http://www.medworm.com/index.php?rid=3222356&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20111852%26dopt%3DAbstract CONCLUSIONS: The results of this Swiss study are consistent with previous research in the USA. The fact that many adults with ADHD are motivated to quit smoking and that they actually make use of support in quitting is crucial for secondary tobacco prevention. PMID: 20111852 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3222356 Sat, 30 Jan 2010 00:00:00 +0100 3222356 http://www.medworm.com/index.php?rid=3222355&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20111853%26dopt%3DAbstract Authors: Handel S, Jäger M This contribution describes a case that led to hospitalization in our psychiatric clinic due to emotional instability and suicidal behavior resulting from a gender identity disorder (female to male transsexualism). During inpatient treatment that lasted for almost 4 months, considerable improvement of the patient's emotional instability and suicidal behavior could be achieved. Treatment success was maintained up to follow-up (18 months after discharge). The syndrome-oriented pharmacotherapy with quetiapine and valproate which had been administered as off-label medication to stabilize the patient's mood could be considered the effective factor. A few months after release from inpatient care, cross-gender hormone therapy was initiated accompanied by outpat... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3222355 Sat, 30 Jan 2010 00:00:00 +0100 3222355 http://www.medworm.com/index.php?rid=3222354&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20111854%26dopt%3DAbstract Authors: Bauer J, Pfeiffer C, Burr W We evaluated factors possibly influencing serum concentrations of levetiracetam (LEV-SC). The study included 163 patients with epilepsy (91 men, 72 women; mean age 39.6 years). The duration of treatment on first analysis was 226 days; the mean daily dose amounted to 2,434 mg. In each patient between one and seven measurements were carried out (mean 2.2). LEV-SC significantly depended on daily dosage and the interval between the time the medication was taken and the time of blood extraction. A marked drop in LEV-SC was observed 4-5 h following ingestion. Carbamazepine, oxcarbazepine and clobazam reduced LEV-SC, whereas valproate elevated LEV-SC significantly. When assessing evaluation of compliance these factors have to be taken into consideration wh... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3222354 Sat, 30 Jan 2010 00:00:00 +0100 3222354 http://www.medworm.com/index.php?rid=3222353&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20111855%26dopt%3DAbstract Authors: Schmutzhard E Central nervous system infections and infestations by protozoa and helminths constitute a problem of increasing importance throughout all of central European and northern/western countries. This is partially due to the globalisation of our society, tourists and business people being more frequently exposed to parasitic infection/infestation in tropical countries than in moderate climate countries. On top of that, migrants may import chronic infestations and infections with parasitic pathogens, eventually also - sometimes exclusively - involving the nervous system. Knowledge of epidemiology, initial clinical signs and symptoms, diagnostic procedures as well as specific chemotherapeutic therapies and adjunctive therapeutic strategies is of utmost important in all o... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3222353 Sat, 30 Jan 2010 00:00:00 +0100 3222353 http://www.medworm.com/index.php?rid=3222352&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20112006%26dopt%3DAbstract Authors: Husseini L, Leussink VI, Kieseier BC, Hartung HP Mobility limitation is a frequent clinical symptom of multiple sclerosis (MS) that poses a therapeutic challenge. For years results of animal experiments and clinical experience have indicated that the potassium channel blocker 4-aminopyridine improves axonal excitatory circuits and thus muscular strength in demyelinating diseases. A recently conducted randomized, placebo-controlled, multicenter phase 3 clinical trial in MS patients was able to show that an oral sustained-release formulation of 4-aminopyridine (Fampridine-SR) represents a suitable agent for treatment of walking disability in MS patients.This overview presents the study data and discusses the value of 4-aminopyridine for the symptomatic treatment of MS as a neuro... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3222352 Sat, 30 Jan 2010 00:00:00 +0100 3222352 http://www.medworm.com/index.php?rid=3222359&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20108084%26dopt%3DAbstract Authors: Paslakis G, Kiefer F, Diehl A, Alm B, Sobanski E Attention-deficit/hyperactivity disorder (ADHD) in adults is often associated with a comorbid substance use disorder (SUD). To date, no treatment algorithms are available. The question of whether the administration of methylphenidate (MPH) is justified in the treatment of adult patients with ADHD and comorbid SUD still remains unclear. While animal studies indicate an addictive potential of intravenous application of the drug, controlled oral treatment with MPH does not seem to carry the potential for abuse in humans. It remains controversial whether MPH treatment of ADHD during childhood protects against the development of SUD during adulthood. Although data remain inconsistent, a small number of studies and our own clinical ob... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3222359 Fri, 29 Jan 2010 00:00:00 +0100 3222359 http://www.medworm.com/index.php?rid=3222358&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20108085%26dopt%3DAbstract Authors: Menon S, Lenhard T, Meyding-Lamadé U The morbidity and mortality of viral CNS infections can be reduced through early initiation of therapy, which could be specific or in most cases symptomatic. This in turn requires the physician to consider meningoencephalitis as a differential diagnosis.Increasing climate changes, global air travel and changing immune responses contribute to the emergence of rather rare viral pathogens on our continent. Thus, neurologists in Europe are facing an enormous challenge due to lacking knowledge and experience of these new germs, which needs to be taken care of.Novel therapeutic approaches with e.g. monoclonal antibodies awaken the hope of mitigating the partially lethal courses of these diseases. PMID: 20108085 [PubMed - as supplied by p... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3222358 Fri, 29 Jan 2010 00:00:00 +0100 3222358 http://www.medworm.com/index.php?rid=3216938&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20101490%26dopt%3DAbstract CONCLUSIONS: Combined brainstem reflex recordings (MR and late BR components) support the clinical examination. To evaluate the long-term prognosis brainstem reflexes and EAEP recordings should be used. PMID: 20101490 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3216938 Wed, 27 Jan 2010 00:00:00 +0100 3216938 http://www.medworm.com/index.php?rid=3216937&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20101491%26dopt%3DAbstract Authors: Jacobi C, Lenhard T, Meyding-Lamadé U Vasculitis and vasculopathies of the central and peripheral nervous system can be caused by infectious diseases. Vasculitis can lead to stenosis, occlusion and aneurysm formation of blood vessels which may result in stroke or cerebral haemorrhage. In cases of peripheral nervous system involvement mononeuritis multiplex and symmetric peripheral neuropathy are possible. The diagnosis is based on clinical presentation, serology, cerebrospinal fluid analysis and neuroradiologic examinations. In cases of peripheral neuropathy neurophysiologic examinations and biopsy of the sural nerve can lead to the diagnosis. A fast and efficient antimicrobial therapy is the most important treatment option. In cases of peripheral neuropathies short-term ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3216937 Wed, 27 Jan 2010 00:00:00 +0100 3216937 http://www.medworm.com/index.php?rid=3190128&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20084360%26dopt%3DAbstract Authors: Klein M, Pfister HW Bacterial infections of the nervous system are often challenging for the treating physician because sensitivity and specificity of clinical signs do not reach 100%. In patients with neuroborreliosis and bacterial meningitis, investigations of the cerebrospinal fluid are necessary to confirm or rule out the diagnosis. In intracranial and spinal abscesses, the alterations of the cerebrospinal fluid are most often non-specific and imaging and neurosurgical aspiration of purulent material are additionally needed to make the diagnosis. Here, the relevant diagnostic and therapeutic aspects of three common bacterial infections of the central nervous system (neuroborreliosis, bacterial meningitis, and brain abscess) are discussed. PMID: 20084360 [PubMed - as su... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3190128 Wed, 20 Jan 2010 00:00:00 +0100 3190128 http://www.medworm.com/index.php?rid=3182591&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082191%26dopt%3DAbstract Authors: Schnell T, Neisius K, Daumann J, Gouzoulis-Mayfrank E Comorbid substance use disorders in schizophrenia are of high clinical relevance, because they are common and they are mostly associated with an unfavourable long-term prognosis. Whereas the clinical impression suggests a continuous increase of substance use disorders in patients with schizophrenia over the last 10-20 years, results from epidemiological studies have been inconsistent. The aim of the present investigation was to study the prevalence of substance use disorders within a large sample of patients with schizophrenia in a large German city (Cologne). The prevalence data were examined in different treatment settings (outpatient vs inpatient, university hospital vs mental health hospital). Risk factors for substance... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3182591 Sat, 16 Jan 2010 00:00:00 +0100 3182591 http://www.medworm.com/index.php?rid=3179818&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076938%26dopt%3DAbstract Authors: Habermeyer E, Wolff R, Gillner M, Strohm R, Kutscher S We assessed data concerning demographic, criminological und psychiatric characteristics of all patients with disorders of the schizophrenic spectrum, who were detained in the forensic psychiatric departments of Mecklenburg-West Pomerania, a federal state of Germany, in 2007. Of the 202 patients of both clinics, 45 suffer from a disorder of the schizophrenic spectrum assessed in ICD-10: F20-F29, which corresponds to 22%. This level is markedly lower than in other regions of Germany. But similarly to results assessed in other federal states of Germany and in Austria there is a high rate of pre-treatment in general psychiatric institutions. It remains a relevant task for general psychiatry to establish adequate interventions ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3179818 Sat, 16 Jan 2010 00:00:00 +0100 3179818 http://www.medworm.com/index.php?rid=3167794&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20066394%26dopt%3DAbstract Authors: Gründer G, Vernaleken I, Bartenstein P This review presents the basic essentials of the application of nuclear medicine technology in psychiatry, i.e., positron emission tomography (PET) and single photon emission computed tomography (SPECT). These include integral principles of physics and radiochemistry as well as of data acquisition and analysis. Significant findings from applications in research and the clinical setting (schizophrenic and affective disorders, substance abuse, dementia) illustrate the huge potential of these methods. They have helped to deepen the understanding of the neurobiology of those disorders and the mechanism of action of psychotropic drugs. Due to its unmatched sensitivity, molecular imaging with PET and SPECT represents an important complemen... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3167794 Wed, 13 Jan 2010 00:00:00 +0100 3167794 http://www.medworm.com/index.php?rid=3167793&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20066395%26dopt%3DAbstract Authors: Eickhoff SB, Nickl-Jockschat T, Kurth F Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) have brought about an immense increase in findings on the localization of motor, cognitive, and affective processes in the human brain. However, considerable discrepancy still exists between the multitude of available studies and the limited validity of the individual experiments. Quantitative, coordinate-based meta-analyses are suited to objectively integrate these numerous findings as completely as possible. There are a number of different methods for coordinate-based voxel-wise meta-analyses, but the technique of"activation likelihood estimation" (ALE) has largely prevailed. This contribution describes the principles, methods, and statistical analysis ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3167793 Wed, 13 Jan 2010 00:00:00 +0100 3167793 http://www.medworm.com/index.php?rid=3156912&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20057981%26dopt%3DAbstract Authors: Derntl B, Habel U, Schneider F Due to its many advantages and the technical improvements, functional magnetic resonance imaging (fMRI) has become the most popular and versatile imaging method in psychiatric research. The scope of this manuscript is to briefly introduce the basics of MR physics, the blood oxygenation level-dependent (BOLD) contrast as well as the principles of MR study design and functional data analysis. The presentation of exemplary studies on emotion recognition and empathy in schizophrenia patients will highlight the importance of MR methods in psychiatry. Finally, we will demonstrate insights into new developments that will further boost MR techniques in clinical research and will help to gain more insight into dysfunctional neural networks underlying cogn... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3156912 Sat, 09 Jan 2010 00:00:00 +0100 3156912 http://www.medworm.com/index.php?rid=3109979&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024526%26dopt%3DAbstract CONCLUSION: Developing computer-assisted treatment pathways based on S3 Guidelines and incorporating them into existing hospital information systems is feasible and well accepted by users. The initial effects on guideline compliance are mostly positive, but not strongly so. Moreover, there was a reduction in duration of hospital stay. Disease-related factors such as disease severity appear to compromise guideline compliance. PMID: 20024526 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3109979 Sun, 20 Dec 2009 00:00:00 +0100 3109979 http://www.medworm.com/index.php?rid=3109978&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024527%26dopt%3DAbstract Authors: Mathiak K, Junghöfer M, Pantev C, Rockstroh B Neuropsychiatric disorders usually come with only sublime structural changes. Functional imaging can point at specific disturbances in information processing in neural networks. Besides imaging of receptor and metabolic functions with PET and fMRI, electromagnetic methods such as electroencephalography (EEG) and magnetoencephalography (MEG) offer the possibility for imaging of dynamic dysfunctions. As compared to EEG, MEG has a shorter history and is less common despite offering considerable advantages in temporospatial resolution and sensitivity to detect impaired signal processing and network functioning which renders it particularly interesting for psychiatric applications. Disturbed processing in the auditory and visual do... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3109978 Sun, 20 Dec 2009 00:00:00 +0100 3109978 http://www.medworm.com/index.php?rid=3101590&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013254%26dopt%3DAbstract Authors: Dannlowski U, Konrad C, Arolt V, Suslow T Major depression is one of the most frequent and serious psychiatric diseases. Although the disease is highly heritable, the search for candidate genes has been of limited success hitherto. The complex, polygenetic hereditary transmissions coding for heterogeneous, clinically defined phenotypes such as major depression may be better identified using the endophenotype approach. A recent study, reporting an association of the risk allele in a serotonin transporter polymorphism (5-HTTLPR) with increased amygdala responsiveness to aversive stimuli, stimulated the new research field of imaging genetics, which is characterized by the choice of neurobiological activity patterns as endophenotypes. This review discusses recent studies from this... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3101590 Thu, 17 Dec 2009 00:00:00 +0100 3101590 http://www.medworm.com/index.php?rid=3101591&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20012932%26dopt%3DAbstract Authors: Doerr JP, Hirscher V, Riemann D, Voderholzer U Slow-wave sleep is defined as sleep stages 3 and 4 that characteristically show slow delta EEG activity during polysomnography. The percentage of slow-wave sleep normally declines with age. Sleep disorders are a common symptom of many psychiatric disorders. In polysomnographic recordings they mostly manifest as disturbances of sleep continuity. In some disorders changes in REM sleep are also found. A reduction of slow-wave sleep has most often been described in patients with depression and addictive disorders. More recent research implicates slow-wave sleep as an important factor in memory consolidation, especially the contents of declarative memory. Psychotropic drugs influence sleep in different ways. Hypnotic substances can red... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3101591 Wed, 16 Dec 2009 00:00:00 +0100 3101591 http://www.medworm.com/index.php?rid=3060095&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19957066%26dopt%3DAbstract Authors: Hacke W, Diener HC, Hartung HP, Elger C, Brandt TH PMID: 19957066 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3060095 Tue, 01 Dec 2009 00:00:00 +0100 3060095 http://www.medworm.com/index.php?rid=3060094&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19957067%26dopt%3DAbstract Authors: PMID: 19957067 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3060094 Tue, 01 Dec 2009 00:00:00 +0100 3060094 http://www.medworm.com/index.php?rid=3060093&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19957068%26dopt%3DAbstract Authors: PMID: 19957068 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3060093 Tue, 01 Dec 2009 00:00:00 +0100 3060093 http://www.medworm.com/index.php?rid=3060092&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19957069%26dopt%3DAbstract Authors: PMID: 19957069 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3060092 Tue, 01 Dec 2009 00:00:00 +0100 3060092 http://www.medworm.com/index.php?rid=3029599&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19936695%26dopt%3DAbstract Authors: Schlander M, Trott GE, Schwarz O Attention deficit hyperactivity disorder (ADHD) has been associated with a continuous increase of health care utilization and thus expenditures. This raises the issue of cost-effectiveness of health care provided for patients with ADHD. Comparative health economic evaluations generate relevant insights and typically report incremental cost-effectiveness ratios (ICERs) of alternatives versus an established standard. Typically, results of cost-effectiveness analyses (CEAs) are reported in terms of incremental cost-effectiveness ratios (ICERs). International evaluations, as well specific adaptations to Germany, indicate an acceptable to attractive cost-effectiveness - according to currently used international benchmarks - of an intense medication ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3029599 Sat, 21 Nov 2009 00:00:00 +0100 3029599 http://www.medworm.com/index.php?rid=3029598&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19936696%26dopt%3DAbstract Authors: Schlander M, Trott GE, Schwarz O In the German region of Nordbaden, 5% of children (aged 7-12 years) and 1.3% of adolescents (aged 13-19 years) were diagnosed with attention deficit hyperactivity disorder (ADHD) in 2003. About two thirds of these patients were not seen by a physician specialized in psychiatry. Now the National Association of Statutory Health Insurance Physicians in Germany (Kassenaerztliche Bundesvereinigung, KBV) has developed a proposal for the integrated provision of care for these patients, combining a guidelines-oriented multidisciplinary approach with a system of quality assurance. Against this background, currently available ADHD-related data are presented, covering epidemiology, comorbidity and differential diagnosis, health care utilization, and cost ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3029598 Sat, 21 Nov 2009 00:00:00 +0100 3029598 http://www.medworm.com/index.php?rid=3013244&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921503%26dopt%3DAbstract Nervenarzt. 2009 Nov 19; Authors: Strupp M, Katsarava Z The major invasive procedure of the neurologist is the spinal tap. Its most frequent complication is post-lumbar puncture syndrome/headache. The syndrome's leading symptom is posture-dependent headache, which is caused by the prolonged escape of CSF from a dural leak. Its frequency lies between 1 and 30%, depending on the technique used for lumbar puncture. An important measure for reducing the risk of its occurrence is the use of a small (22-gauge), atraumatic Sprotte or Whitacre needle. The treatment of choice for the syndrome is caffeine, and if ineffective, then an epidural blood patch (at least 20 ml of the patient's own blood). Spontaneous low CSF pressure is due to a dural tear; it has the same symptoms as post-dural pu... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3013244 Thu, 19 Nov 2009 00:00:00 +0100 3013244 http://www.medworm.com/index.php?rid=3013245&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921502%26dopt%3DAbstract [Prof. Dr. med. Franz Müller-Spahn : 18.08.1950 to 04.08.2009.] Nervenarzt. 2009 Nov 18; Authors: Dittmann V, Müller N, Möller HJ PMID: 19921502 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3013245 Wed, 18 Nov 2009 00:00:00 +0100 3013245 http://www.medworm.com/index.php?rid=3004884&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19915806%26dopt%3DAbstract Authors: Bauer J, Neumann M The German guidelines for driving licenses concerning people with epilepsy or those who experienced single epileptic seizures have been revised. In cases of epilepsy a seizure-free period of 12 months is required for group 1 drivers (e.g. passenger cars). A seizure-free period of 5 years without antiepileptic drugs is mandatory for group 2 drivers (e.g. trucks) with epilepsy. A seizure-free interval of 3 months (group 1) or 6 months (group 2) is required after a single epileptic seizure caused by a plausible provocative factor. The guidelines stress that people who experienced a seizure induced by sleep deprivation may have a genetic disposition to generalized seizures. In such patients a complete electroencephalographic work-up is necessary before conclusio... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=3004884 Fri, 13 Nov 2009 00:00:00 +0100 3004884 http://www.medworm.com/index.php?rid=2993178&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19902165%26dopt%3DAbstract Authors: Veselinović T, Himmerich H In recent years, weight gain has increasingly gained attention as a side effect of antipsychotic therapy due to its metabolic and cardiovascular health risks and its negative effect on therapy compliance. The various antipsychotics show clear differences concerning their influence on body weight. These differences seem to be mainly due to the affinity of these substances to the histaminergic H1 receptors and due to serotonergic mechanisms. In the hypothalamus, the antihistaminergic effect of those antipsychotics which are associated with a high amount of weight gain leads to an increase of the activity of the adenosine monophosphate-activated protein kinase (AMPK). Hypothalamic AMPK activity has an integrative function regarding orexigenic and ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2993178 Wed, 11 Nov 2009 00:00:00 +0100 2993178 http://www.medworm.com/index.php?rid=2993177&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19902166%26dopt%3DAbstract CONCLUSIONS: Starting HAART, HIV-1-positive patients may develop an aseptic type of IRIS of the CNS without any detectable opportunistic infection, a finding that has not yet been published. This makes them susceptible for successful treatment with corticosteroids. Perhaps IRIS has a higher incidence in African patients and the patients have a poorer outcome than Caucasians. PMID: 19902166 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2993177 Wed, 11 Nov 2009 00:00:00 +0100 2993177 http://www.medworm.com/index.php?rid=2971010&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19888559%26dopt%3DAbstract We report on a previously healthy 36-year-old woman who presented with encephalopathy, central weakness of her right leg and multiple white matter lesions on MRI. Shortly thereafter, inner ear deafness developed and funduscopy revealed occlusions of branch retinal arteries. A diagnosis of retino-cochlear-cerebral vasculopathy or Susac's syndrome was established and steroid-based immunotherapy with high-dose corticosteroids was initiated. Steroid reduction led to repeated clinical worsening, so that immunotherapy was sequentially escalated. Finally, high-dose cyclophosphamide every 4 weeks led to sufficient control of disease activity. Recent publications have argued for an early and aggressive immunosuppression in Susac's syndrome based on clinical and histological similarities with juveni... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2971010 Wed, 04 Nov 2009 00:00:00 +0100 2971010 http://www.medworm.com/index.php?rid=2947196&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19876611%26dopt%3DAbstract CONCLUSION: The PsychPV requirements must be urgently adapted so that more time is again available for the direct patient contact. PMID: 19876611 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2947196 Sat, 31 Oct 2009 00:00:00 +0100 2947196 http://www.medworm.com/index.php?rid=2939917&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19859681%26dopt%3DAbstract Conclusion: How should a meaningful meta-analysis of long-term psychodynamic psychotherapy be designed?] Nervenarzt. 2009 Oct 28; Authors: Rief W, Hofmann SG In their answer to our critical evaluation of their meta-analysis about long-term psychodynamic psychotherapy (LTPP), Leichsenring and Rabung claim that all our critical points could be rejected. This is surprising, as the authors already confirmed different shortcomings of their analysis. Our major criticism is that the meta-analysis is based on very few high-quality studies (including follow-up assessments), but on many studies with poor quality and/or observational studies resulting in serious publication bias. Neither the treatment of interest (LTPP) nor the target group is sufficiently circumscribed, but the very few ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2939917 Wed, 28 Oct 2009 00:00:00 +0100 2939917 http://www.medworm.com/index.php?rid=2939916&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19859682%26dopt%3DAbstract Authors: Dümpelmann M PMID: 19859682 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2939916 Wed, 28 Oct 2009 00:00:00 +0100 2939916 http://www.medworm.com/index.php?rid=2939915&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19859683%26dopt%3DAbstract Authors: Benecke C, Boothe B, Frommer J, Huber D, Krause R, Staats H Rief and Hofmann (2009, Nervenarzt 80:593-597) harshly criticise the meta-analysis on the effectiveness of long-term psychodynamic psychotherapy (LTPP) by Leichsenring and Rabung (2008, JAMA 300(13):1551-1565). They find fault with the inclusion of naturalistic studies in addition to randomised clinical trials. Furthermore, they criticise the heterogeneity of the treatments included and the disorders studied. They suspect that a number of RCTs of LTPP with negative results for LTPP have been done and not been published. This paper comments on the following issues: the strict determination of RCTs is scientifically outdated and in order to investigate the effectiveness of psychotherapy naturalistic studies have to be i... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2939915 Wed, 28 Oct 2009 00:00:00 +0100 2939915 http://www.medworm.com/index.php?rid=2939914&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19859684%26dopt%3DAbstract Authors: PMID: 19859684 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2939914 Wed, 28 Oct 2009 00:00:00 +0100 2939914 http://www.medworm.com/index.php?rid=2939913&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19859685%26dopt%3DAbstract Authors: Förstl H, Perneczky R, Karenberg A, Diehl-Schmid J, Lautenschlager NT Modern developmental psychology tends to draw a positive, resource-based picture of human aging. We will however focus on more difficult aspects of personality in old age which are of psychiatric relevance: the persistence of cluster A and C personality disorders, antisocial personality in the elderly; the interaction of personality and a detection of mild cognitive impairment (MCI); personality features as risk or protective factors or early signs of Alzheimer's dementia; changes of personality in Parkinson's disease and frontotemporal dementia. We will briefly mention recent neuroimaging studies which appear to suggest a functional neuroanatomy of personality. A quote from Cicero's cato major, de sene... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2939913 Wed, 28 Oct 2009 00:00:00 +0100 2939913 http://www.medworm.com/index.php?rid=2931674&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19855949%26dopt%3DAbstract Authors: Neuner I, Ludolph A Chronic motor and vocal tics lasting longer than a year are classified as Tourette's syndrome (TS). Tics mostly manifest before the age of 11 years. Boys are affected at a threefold higher rate than girls. Tics are often worst at the age of 14; in 50% of the cases the tic symptoms will remit nearly completely. Severely affected patients often suffer from comorbidities. In childhood and adolescence the most common comorbid condition is attention deficit hyperactivity disorder (ADHD). Obsessive-compulsive behaviour, anxiety and affective disorder might occur in the course of TS. A dysregulation in the dopaminergic neurotransmission in the cortico-striatal-thalamic-cortical circuits (CSTC) might be the underlying neurobiological basis. The psychotropic substan... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2931674 Sun, 25 Oct 2009 00:00:00 +0100 2931674 http://www.medworm.com/index.php?rid=2925245&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851742%26dopt%3DAbstract Authors: Leichsenring F, Rabung S Rief and Hofmann (Nervenarzt 80:593-597) criticize in a very detailed comment our meta-analysis of long-term psychodynamic psychotherapy (JAMA 300:1551-1565). Although our article clearly included information that our meta-analysis addressed long-term psychodynamic psychotherapy of at least 50 sessions or at least 1 year duration, Rief and Hofmann allege that we studied "psychoanalysis" or "long-term psychoanalysis". Then they "show" for some of the studies we included that these studies did not address "psychoanalysis" or "long-term psychoanalysis" - which they did indeed not, but had never been claimed by us. For all other points of criticism put forward by the authors we show that they are not tenable as well. In addition, we show that Rief and Hofm... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2925245 Sat, 24 Oct 2009 00:00:00 +0100 2925245 http://www.medworm.com/index.php?rid=2925243&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851744%26dopt%3DAbstract Authors: Schneider F, Maier W PMID: 19851744 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2925243 Sat, 24 Oct 2009 00:00:00 +0100 2925243 http://www.medworm.com/index.php?rid=2925242&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851745%26dopt%3DAbstract Authors: Normann C, Boldt J, Maio G, Berger M Pharmacological neuroenhancement is an attempt to increase cognitive performance in healthy humans. Learning and memory, attention and vigilance or mood and social interaction are targeted by a modulation of brain plasticity. Firstly, an analysis of the current state of research shows that, until now, clinical trials of neuroenhancing drugs have demonstrated only limited efficacy and long-term side effects remain largely unexplored. Secondly, we argue that, from an ethical perspective, neuroenhancement differs from socially mediated methods of learning. Pharmacological neuroenhancement is based on notions of efficacy and control that threaten to undermine other important aspects of mental capacities. PMID: 19851745 [PubMed - as supplied... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2925242 Sat, 24 Oct 2009 00:00:00 +0100 2925242 http://www.medworm.com/index.php?rid=2925244&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851743%26dopt%3DAbstract We report on a 38-year-old male patient who was diagnosed with a hepatic form of Wilson's disease at age 12 and with multiple sclerosis at age 38. Intravenous radio copper test confirmed the diagnosis of Wilson's disease. Multiple sclerosis was diagnosed after occurrence of transient sensory disturbances in both legs, based on typical changes on MRI over the course of 2 years, in the cerebrospinal fluid and in multimodal evoked potentials.Although Wilson's disease and multiple sclerosis are known as distinct diseases with a completely different pathophysiology, symptoms and results of evoked potentials overlap, and they share a common historic background. Similarities and differences of both disorders are discussed. PMID: 19851743 [PubMed - as supplied by publisher] (Source: Der Nerven... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2925244 Fri, 23 Oct 2009 00:00:00 +0100 2925244 http://www.medworm.com/index.php?rid=2908691&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19838661%26dopt%3DAbstract CONCLUSION: This study pointed out the necessity for psychotherapeutic help after surgery to manage already existing or new psychological needs due to gastric banding. PMID: 19838661 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2908691 Fri, 16 Oct 2009 23:00:00 +0100 2908691 http://www.medworm.com/index.php?rid=2908690&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19838662%26dopt%3DAbstract Authors: Löbermann M, Winkelmann A, Reisinger EC, Zettl UK Vaccinations to prevent communicable diseases are, like in other chronic diseases, of special importance in patients with multiple sclerosis (MS). Various bacterial and viral infections have been shown to induce relapses of MS. Reports of possible adverse effects of vaccinations on the course of multiple sclerosis have led patients and treating physicians to exercise caution in the use of vaccines. A number of vaccines have been studied with respect to the risk in MS patients. Some vaccines, for example against yellow fever, are not indicated in MS due to the risk of MS exacerbation. In contrast, tetanus or hepatitis B vaccines do not represent a risk for manifestation or disease progression of MS. Before and during immuno... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2908690 Fri, 16 Oct 2009 23:00:00 +0100 2908690 http://www.medworm.com/index.php?rid=2908689&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19838663%26dopt%3DAbstract Authors: Mann K, Laucht M, Weyerer S Alcohol and nicotine are with us during most of our lifetime. About 4,000 children with fetal alcohol syndrome and another 20,000 children with fetal alcohol effects are born per year in Germany. Alcohol contributes to accidents and suicides especially in young people. It is particularly toxic for the developing brain.Germany is among the countries with a high consumption of alcohol and nicotine. Consequently substance-related diseases are highly prevalent. In the group of people aged 65 and older we expect a doubling of alcohol problems within the next 10 years. This will also lead to a sharp increase in alcohol-related dementias. Overall, treatment is effective especially if one considers the chronic relapsing nature of the disorder. Unfortunately... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2908689 Fri, 16 Oct 2009 23:00:00 +0100 2908689 http://www.medworm.com/index.php?rid=2908688&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19838664%26dopt%3DAbstract Authors: Fritze J Demand for health services is in principle unlimited, in contrast to resources. People covered by public health funds in principle have equal access to treatment according to the highest level of medical evidence available. In order to restrict expenditure the legislator stipulates different instruments. These include reference pricing for generics as well as price capping. The legislator still shies from price fixing which is well established in other states. Instead, office-based physicians are confronted by law with rationing decisions concerning their own services as well as services prescribed where the mentally ill are at special risk of becoming victims of intransparency, as exemplified by the heterogeneity of the prescription of psychotropic drugs. A systemati... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2908688 Fri, 16 Oct 2009 23:00:00 +0100 2908688 http://www.medworm.com/index.php?rid=2899558&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19830471%26dopt%3DAbstract Authors: PMID: 19830471 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2899558 Wed, 30 Sep 2009 23:00:00 +0100 2899558 http://www.medworm.com/index.php?rid=2899557&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19830472%26dopt%3DAbstract Authors: PMID: 19830472 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2899557 Wed, 30 Sep 2009 23:00:00 +0100 2899557 http://www.medworm.com/index.php?rid=2899556&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19830473%26dopt%3DAbstract Authors: PMID: 19830473 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2899556 Wed, 30 Sep 2009 23:00:00 +0100 2899556 http://www.medworm.com/index.php?rid=2843223&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19784613%26dopt%3DAbstract Authors: Schouler-Ocak M, Schepker R, Bretz HJ, Hartkamp N, Koch E, Penka S, Hauth I, Rapp MA, Aichberger MC, Heinz A In a representative nationwide survey, the Psychiatry and Migration Working Group of the German Federal Conference of Psychiatric Hospital Directors examined the use of inpatient psychiatric and psychotherapeutic services in Germany by patients of immigrant origin. Questionnaires were sent to a total of 350 general hospital psychiatric clinics throughout Germany and 131 responded by the specified deadline (19 July 2006).In our study, persons of immigrant origin comprised 17% of patients in the responding facilities, which confirmed the results of the pilot study in 2004 of 17.4%. This indicates that the percentage of inpatient psychiatric services used by patients of im... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2843223 Sat, 26 Sep 2009 23:00:00 +0100 2843223 http://www.medworm.com/index.php?rid=2832928&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19779889%26dopt%3DAbstract Authors: Hartung HP Multiple sclerosis (MS) has traditionally been considered to be a T cell-mediated disease. However, there is an increasing body of evidence for the involvement of B cells and autoantibodies in the pathology of this disease, providing a rationale for treatment strategies directed against B cells. This paper summarizes the evidence for a key role of B cells in the immunopathology of MS and reviews data supporting the use of a novel B cell-targeted therapy, atacicept, for this condition. Atacicept is a human recombinant fusion protein that comprises the binding portion of a receptor for both BLyS (B Lymphocyte Stimulator) and APRIL (A PRoliferation-Inducing Ligand), two cytokines that have been identified as important regulators of B cell maturation, function and survi... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2832928 Fri, 25 Sep 2009 23:00:00 +0100 2832928 http://www.medworm.com/index.php?rid=2820691&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19768444%26dopt%3DAbstract We report on a 36-year-old patient with an acute cerebral infarction due to a spontaneous dissection of both internal carotid arteries in conjunction with type I osteogenesis imperfecta. Spontaneous dissections of cerebral arteries (DCA) represent a common cause of cerebral infarctions in younger patients. Our case shows that a hereditary connective tissue disorder should be considered in all patients with "spontaneous" DCA. The identification of an - initially unknown - hereditary connective tissue disorder may contribute to primary and secondary prophylaxis of cerebral ischemia. PMID: 19768444 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2820691 Sat, 19 Sep 2009 23:00:00 +0100 2820691 http://www.medworm.com/index.php?rid=2820690&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19768445%26dopt%3DAbstract Authors: Pliska G Based on increasing criticism concerning operational diagnostics in psychiatry, the concept of schizoid personality disorder in ICD and DSM is discussed critically. In a case study regarding the poet and doctor Gottfried Benn, the limitation of manualized, context-independent diagnostic systems is shown. In contrast Ernst Kretschmer's concept of schizoidism seems suitable to describe a schizoid character in his ambiguity. PMID: 19768445 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2820690 Sat, 19 Sep 2009 23:00:00 +0100 2820690 http://www.medworm.com/index.php?rid=2820689&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19768446%26dopt%3DAbstract Authors: Hacke W, Diener HC, Hartung HP, Elger C, Brandt TH PMID: 19768446 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2820689 Sat, 19 Sep 2009 23:00:00 +0100 2820689 http://www.medworm.com/index.php?rid=2820688&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19768447%26dopt%3DAbstract Authors: Konrad K, Rösler M Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children. ADHD is often chronic persisting into adulthood in about 60% of patients. The disorder is frequently associated with co-occurring disruptive, anxiety, mood and personality disorders as well as substance abuse. The diagnosis of ADHD has to be based on careful assessment of symptoms and impairments in the different phases of life. Recent neuroimaging and genetic data support the neurobiological basis of the disorder. Multimodal treatment options including stimulants, antidepressants and behavioral therapy play a fundamental role in the management of ADHD across the life span. PMID: 19768447 [PubMed - as supplied by publisher] (Source: Der ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2820688 Sat, 19 Sep 2009 23:00:00 +0100 2820688 http://www.medworm.com/index.php?rid=2820687&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19768448%26dopt%3DAbstract Authors: Jucksch V, Salbach-Andrae H, Lehmkuhl U The diagnosis of a personality disorder is defined by the fact that personality traits are formed by early childhood, but German clinicians very rarely diagnose children and adolescents with personality disorders. Opponents of diagnosing personality disorders in childhood want to avoid labeling and refer to the developmental aspect of the personality. Supporters argue that children and adolescents already possess a describable personality and the developmental process continues into adulthood. By recognizing the pathological personality tendencies early enough allows an early therapy which can prevent an acute progression. The aim of the present study was to ascertain whether the Structured Clinical Interview for DSM-IV Personality Disor... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2820687 Sat, 19 Sep 2009 23:00:00 +0100 2820687 http://www.medworm.com/index.php?rid=2812716&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19763528%26dopt%3DAbstract CONCLUSION: Patients with FTLD should cease driving as soon as possible in the course of the disease. With patients suffering from mild AD an individual assessment should be made. PMID: 19763528 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2812716 Fri, 18 Sep 2009 23:00:00 +0100 2812716 http://www.medworm.com/index.php?rid=2812715&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19763529%26dopt%3DAbstract Authors: Finke C, Horváth R, Holinski-Feder E, Ploner CJ Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently characterized adult onset neurodegenerative disorder affecting both male and female (male>female) carriers of premutation CGG repeat expansions of the FMR1 gene. Onset typically occurs after the age of 50 years with a lifetime risk of FXTAS in males of about 1 in 3,000-6,000. Core features include progressive gait ataxia and cerebellar tremor with associated features of cognitive deficits, peripheral neuropathy and dysautonomia. The diagnosis of FXTAS is established based on clinical presentation, cerebral imaging and genetic testing. Due to the still low level of awareness of FXTAS and its variable clinical picture FXTAS is substantially underdiagnosed. Ho... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2812715 Fri, 18 Sep 2009 23:00:00 +0100 2812715 http://www.medworm.com/index.php?rid=2812714&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19763530%26dopt%3DAbstract CONCLUSION: The RPMS could prove to be an effective option for the treatment of spasticity. However, this method needs further evaluation by evidence-based studies. PMID: 19763530 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2812714 Fri, 18 Sep 2009 23:00:00 +0100 2812714 http://www.medworm.com/index.php?rid=2762840&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19727640%26dopt%3DAbstract Nervenarzt. 2009 Sep 2; Authors: Volz HP, Reischies F, Riedel M Cognitive disorders have become a major topic not only in the scientific community but also among clinicians. Cognitive disorders are of special importance in schizophrenic patients. The present paper gives a survey over the basic definitions and the extent of these disturbances in schizophrenic patients, the main etiopathogenetic hypotheses and the development over time as well as treatment options with special regard to psychopharmacological treatment options. PMID: 19727640 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2762840 Tue, 01 Sep 2009 23:00:00 +0100 2762840 http://www.medworm.com/index.php?rid=2744571&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19711049%26dopt%3DAbstract Authors: Mann K, Kiefer F PMID: 19711049 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2744571 Thu, 27 Aug 2009 23:00:00 +0100 2744571 http://www.medworm.com/index.php?rid=2738569&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707734%26dopt%3DAbstract We present the case of a 49-year-old female patient who underwent a lumbar puncture in the context of an extended diagnostic work-up after a transient ischemic attack. A few days later the patient who suffered from severe post-lumbar puncture headache, developed a lobar hemorrhage due to a cortical venous thrombosis requiring decompression surgery. PMID: 19707734 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2738569 Wed, 26 Aug 2009 23:00:00 +0100 2738569 http://www.medworm.com/index.php?rid=2738568&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707735%26dopt%3DAbstract Authors: Bader A, Frisch U, Wirz-Justice A, Riecher-Rössler A Approximately 11% of pregnant women suffer from major depression which requires treatment and if left untreated there are risks of preterm delivery or low birth weight. The initial difficulty lies in diagnosing the depression itself, as many symptoms of depression can be ascribed to the pregnancy. A further challenge is choosing the appropriate therapy. Treatment options are psychotherapy, antidepressants, electroconvulsive therapy (ECT) or the new possibility of light therapy. A growing number of reports on the side effects of antidepressants in pregnancy have led to uncertainties as to how to proceed. Thus, choosing the most suitable treatment needs to be made together with the pregnant woman and a careful clarificati... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2738568 Wed, 26 Aug 2009 23:00:00 +0100 2738568 http://www.medworm.com/index.php?rid=2738567&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707736%26dopt%3DAbstract CONCLUSION: Impaired sexual function is a common feature in depressive disorders. In some cases sexual problems even persist after remission and the observed sexual dysfunctions negatively affect quality of life. A detailed patient history is important to detect sexual problems. PMID: 19707736 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2738567 Wed, 26 Aug 2009 23:00:00 +0100 2738567 http://www.medworm.com/index.php?rid=2738571&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19705091%26dopt%3DAbstract This article reviews the evidence for such an association. Findings imply the integration of social-cognitive training in a treatment concept for schizophrenia. However, to date it remains elusive whether or not the impact of improved social cognition on psychosocial functioning is stable over prolonged periods of time. To answer this open question requires longitudinal studies that are currently unavailable. PMID: 19705091 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2738571 Tue, 25 Aug 2009 23:00:00 +0100 2738571 http://www.medworm.com/index.php?rid=2738570&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19705092%26dopt%3DAbstract Authors: Diehl-Schmid J, Knels C, Danek A Progressive aphasia (PA) caused by neurodegenerative diseases is much less prevalent than aphasia following vascular brain lesions. Clinically, the progressive aphasias can be divided in progressive non-fluent aphasia, semantic dementia and logopenic aphasia. Differential diagnosis is based on a detailed language assessment and neuroimaging. Compared with the therapy of aphasia following stroke the treatment of patients with PA has been neglected. However, recently potential therapeutic options have been evaluated regarding feasibility and efficacy. PMID: 19705092 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2738570 Tue, 25 Aug 2009 23:00:00 +0100 2738570 http://www.medworm.com/index.php?rid=2731090&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19701619%26dopt%3DAbstract Authors: Foerster K In German psychiatry the concepts of homicide/suicide, collective suicide and double suicide are not precisely defined. These acts should be described formally as homicide with subsequent suicide or as homicide with subsequent suicide attempts. The psychopathological symptoms alone are important for the expertise but not a possible psychodynamic interpretation. PMID: 19701619 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2731090 Sat, 22 Aug 2009 23:00:00 +0100 2731090 http://www.medworm.com/index.php?rid=2731089&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19701620%26dopt%3DAbstract Authors: Bürgy M Despair refers to a psychopathological phenomenon which is difficult to grasp. Its formal structure (Formalanzeige) has previously been described in a publication. The formal structure serves in the following as the basis for a hermeneutic examination of depression. Depressive despair is a development which originates from an antagonism within the biographically evolved personality. This antagonism increasingly tears apart aspects of reality and aspects of desire, begins to oscillate in the form of dichotomies and, in the worst case, leads to hopelessness and suicide. In favourable cases, this process can result in a renewal of one's own individual values. The paper closes with a discussion of the corresponding therapeutic implications. PMID: 19701620 [PubMed ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2731089 Sat, 22 Aug 2009 23:00:00 +0100 2731089 http://www.medworm.com/index.php?rid=2723072&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19697001%26dopt%3DAbstract Authors: Wölfling K, Bühler M, Leménager T, Mörsen C, Mann K Behavioral addictions, especially pathological gambling and internet addiction, have become a growing concern in research and health policy. Similarities between behavioral addictions and substance dependency are currently being discussed in the scientific community. Unfortunately the number of scientific studies on pathological gambling and internet addiction is still very low. The estimated prevalence of pathological gambling among the German population is 0.2-0.5%. These numbers are comparable to prevalence rates reported for illegal drug dependency. About 1.5 million people, i.e. 3% of the German population, are believed to be at risk of internet addiction. Therefore, it is important to investigate in ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2723072 Fri, 21 Aug 2009 23:00:00 +0100 2723072 http://www.medworm.com/index.php?rid=2723075&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19693477%26dopt%3DAbstract Authors: Strubel T, Birkhofer A, Mößmer G, Förstl H Treatment with selective serotonin reuptake inhibitors (SSRI) increases the risk of gastrointestinal bleeding. The combination with non-steroidal anti-inflammatory drugs (NSAIDs) further augments this hazard. Particular precaution is also necessary in patients on platelet aggregation inhibitors, with a known bleeding disorder or preceding gastrointestinal lesions. The incidence of bleeding events apart from the gastrointestinal tract, e.g. intracerebral hemorrhages, is not cumulated under SSRI treatment. This also applies for the combination of SSRI and coumarin or aspirin. Prescribing doctors have to be aware of the bleeding risks of SSRI and should explain this to their patients. High-risk patients have to be followed... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2723075 Thu, 20 Aug 2009 23:00:00 +0100 2723075 http://www.medworm.com/index.php?rid=2723074&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19693478%26dopt%3DAbstract Authors: Kircher T, Leube D, Habel U In patients with schizophrenia, numerous mental processes are impaired, which can be related to brain systems using functional imaging methods (e.g. functional magnetic resonance imaging; fMRI). In this review the methodological and conceptual background of fMRI will first be discussed. Secondly, the cerebral networks involved in important symptoms of schizophrenia such as hallucinations, delusions and formal thought disorders will be outlined. Furthermore, the pathways of the central nervous system involved in cognitive dysfunction in patients with schizophrenia will be described also in the dependence on genotype and medicinal status. Functional imaging methods provide psychiatry and psychotherapy with the unique opportunity to correlate mental pr... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2723074 Thu, 20 Aug 2009 23:00:00 +0100 2723074 http://www.medworm.com/index.php?rid=2723073&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19693479%26dopt%3DAbstract Authors: Batra A, Friederich HM, Lutz U The World Health Organisation (WHO) considers smoking to be the biggest avoidable health risk. The consumption of tobacco leads to health hazards and resulting diseases, the consequences of which are far more serious than those emanating from other addictive substances. Approximately 27% of the German adult population smoke regularly and the proportion of smokers addicted to tobacco or nicotine is estimated to be around 60%. Many of these smokers have undertaken numerous unsuccessful attempts at abstinence. A professional support for smokers who are motivated to give up smoking enhances the chances of success. The current treatment guidelines recommend a combination of psychotherapeutic techniques (e.g. motivational interviewing, behavioural ther... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2723073 Thu, 20 Aug 2009 23:00:00 +0100 2723073 http://www.medworm.com/index.php?rid=2716760&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19690826%26dopt%3DAbstract This article summarizes the current state of knowledge and introduces both methods by highlighting the core therapeutic strategies. PMID: 19690826 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2716760 Wed, 19 Aug 2009 23:00:00 +0100 2716760 http://www.medworm.com/index.php?rid=2700553&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19672571%26dopt%3DAbstract Authors: Kerkhoff G, Marquardt C Disorders of visual search by coordinated eye and head movements are frequently encountered in patients with brain damage. Homonymous visual field disorders, impaired elementary visual capacities (e.g. acuity, contrast sensitivity, convergent fusion, oculomotor disorders), visual neglect, Balint-Holmes syndrome or dementia (e.g. Alzheimer's disease) are the most frequent causes of such disorders. Efficient visual search is necessary to select salient stimuli and bring them onto the fovea in order to perform an in-depth analysis. Visual search is not only an indispensible capacity for visual activities in vocational and private life but is also important for many motor and cognitive abilities such as reaching, grasping, standing, spatial perception, rout... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2700553 Wed, 12 Aug 2009 23:00:00 +0100 2700553 http://www.medworm.com/index.php?rid=2700552&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19672572%26dopt%3DAbstract Authors: Fallgatter AJ, Jacob CP Substance use disorders (e.g. substance addiction, substance abuse) and adult attention-deficit hyperactivity disorders (adult ADHD) are frequent psychiatric disorders with a high individual and social relevance. Complex interactions of common and divergent susceptibility genes and environmental factors are important for both disorders which have a relatively high heritability. Substance use disorders and adult ADHD are both associated with an increased risk for additional axis I disorders. The results of studies with respect to the comorbidity of adult ADHD and substance use disorders are inconsistent. Different hypotheses with respect to comorbidity are under discussion. A standardised diagnostic procedure has to be followed. The consequence of misdia... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2700552 Wed, 12 Aug 2009 23:00:00 +0100 2700552 http://www.medworm.com/index.php?rid=2671987&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19649573%26dopt%3DAbstract Authors: Kiefer F, Grosshans M Recent research suggests similarities between obesity and addictive disorders on both phenomenological and neurobiological levels. In particular neuro-endocrine and imaging studies have shown a close link between homeostatic regulation involved in appetite regulation and regulation of motivation and reward expectancy, which are of special impact for addictive disorders. Based on findings on the neurobiology of reinforcement processes and on the role of classical conditioning in addiction, new interventions for prevention and treatment were developed that offer the opportunity for transfer to the treatment of obesity. A first step may be testing psychotherapeutic and pharmacotherapeutic interventions, which primarily target motivational processes. The rele... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2671987 Sat, 01 Aug 2009 23:00:00 +0100 2671987 http://www.medworm.com/index.php?rid=2638419&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19629426%26dopt%3DAbstract CONCLUSIONS: Apo epsilon4 homozygosity is associated with a family history of dementia and FTD in our cohort if the current clinical criteria are employed. It is likely that autopsy might reveal amyloid beta deposits typical for Alzheimer's disease among the Apo epsilon4 homozygous patients with frontotemporal clinical presentation and neuroimaging consistent with FTD. Apo epsilon4 homozygosity has not yet been defined as an exclusion criterion for the diagnosis of FTD. In the future, a revision of the clinical criteria should consider the ApoE genotype. PMID: 19629426 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2638419 Thu, 23 Jul 2009 23:00:00 +0100 2638419 http://www.medworm.com/index.php?rid=2638418&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19629427%26dopt%3DAbstract Authors: Lempert T Vestibular migraine (VM) presents with attacks of spontaneous or positional vertigo lasting seconds to days. Headaches are often absent during acute attacks, but other symptoms of migraine, such as photophobia or auras may be present. Like migraine headaches VM triggers may include stress, sleep deprivation and hormonal changes. During acute attacks there may be central spontaneous or positional nystagmus and, less commonly, unilateral vestibular hypofunction. In the symptom-free interval vestibular testing shows mostly minor and non-specific findings. The pathogenesis of VM is uncertain but migraine mechanisms may interfere with the vestibular system at the level of the labyrinth, brainstem and cerebral cortex. Treatment includes vestibular suppressants for acute at... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2638418 Thu, 23 Jul 2009 23:00:00 +0100 2638418 http://www.medworm.com/index.php?rid=2638417&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19629428%26dopt%3DAbstract Authors: Eckhardt-Henn A, Tschan R, Best C, Dieterich M Nearly 50% of the patients in general medicine practice suffer from vertigo. In specialized vertigo clinics approximately 50% of the patients have either a primary or secondary somatoform vertigo, which develops after a peripheral vestibular disorder (in nearly 30%). The different subgroups of somatoform vertigo and a pathogenetic model for the two forms of somatoform vertigo are presented. Interesting interactions between neuro-anatomical, neurophysiological and psychological mechanisms concerning anxiety and vertigo are described. Therapeutic principles which are important for the treatment of patients with complex somatoform vertigo disorders are described. PMID: 19629428 [PubMed - as supplied by publisher] (Source: Der Ner... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2638417 Wed, 22 Jul 2009 23:00:00 +0100 2638417 http://www.medworm.com/index.php?rid=2638420&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19626307%26dopt%3DAbstract This article gives an overview on the epidemiology of dizziness/vertigo and of four specific vestibular disorders: benign paroxysmal positional vertigo, vestibular migraine, vestibular neuritis and Menière's disease. PMID: 19626307 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2638420 Tue, 21 Jul 2009 23:00:00 +0100 2638420 http://www.medworm.com/index.php?rid=2606651&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19597797%26dopt%3DAbstract Authors: Kumbier E, Domes G, Herpertz-Dahlmann B, Herpertz SC Since its first use in medical literature the meaning of the term autism has constantly changed. An historical overview indicates that in both adult and child psychiatry autism was first used to refer to a symptom of schizophrenia. Later on the use of the term in child psychiatry took a different independent course, which led to present-day conceptualization of autism, mainly due to the work of Leo Kanner and Hans Asperger. Currently autism and autistic disorders are regarded as severe developmental disorders and, due to their stable nature, have gained considerable attention in adult psychiatry. In order to better understand this development, the path from onset to reception is traced via Kanner and Asperger. In the search ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2606651 Tue, 14 Jul 2009 23:00:00 +0100 2606651 http://www.medworm.com/index.php?rid=2593407&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19590844%26dopt%3DAbstract Authors: Ukley B, Bachhuber A, Hermann W This is a report on a 37-year-old female patient with enzymatically verified Gaucher's disease. The clinical symptoms corresponded to the neuronopathic form of the disease (type 3). A progressive cerebellar syndrome had been developing for 1 year. So far, there have been no records of complex cerebellar symptoms in connection with Gaucher's disease in the literature. After ruling out other differential diagnoses Gaucher's disease was considered to be the cause of such cerebellar symptoms, which could be attributed to toxic glucocerebroside deposits in the cerebellum. PMID: 19590844 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2593407 Fri, 10 Jul 2009 23:00:00 +0100 2593407 http://www.medworm.com/index.php?rid=2593406&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19590845%26dopt%3DAbstract Authors: Jahn K The diagnosis of vertigo syndromes in childhood is considered a difficult challenge. A correct diagnosis, however, makes successful therapy possible, prevents unnecessary investigations and alleviates the worries of parents. Migraine-associated forms of vertigo are very common in children (benign paroxysmal vertigo of childhood, vestibular migraine) and account for about 50% of diagnoses. Acute unilateral vestibular failure in the course of infectious and para-infectious labyrinthitis is also more common in children than in adults. Motion sickness is a frequent and relevant problem in children aged 4-10 years old. A number of rare congenital syndromes can occur with bilateral vestibular failure. Because of the relatively high frequency of brainstem and cerebellar tumors... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2593406 Fri, 10 Jul 2009 23:00:00 +0100 2593406 http://www.medworm.com/index.php?rid=2561845&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19565292%26dopt%3DAbstract Authors: Förstl H Cognitive enhancement, the increase in the mental ability by psychoactive substances and other interventions has received a renewed boost through the development of innovative principle. More than 100 drugs are currently being developed, tested or used for cognitive enhancement.. Cholinesterase inhibitors, memantine, dimebon, ampakines, fluoxetine and other antidepressants, methylphenidate and modafinil are candidates awaiting a larger distribution as cognitive enhancers in healthy individuals, if their advantages can be demonstrated. Beyond more general neuro-ethical reservations regarding neuro-enhancement, future research will need to address the following neuropsychiatric issues: (1) will the benefits of longer term neuro-enhancement outweigh potential disadv... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2561845 Tue, 30 Jun 2009 23:00:00 +0100 2561845 http://www.medworm.com/index.php?rid=2561844&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19565293%26dopt%3DAbstract Authors: PMID: 19565293 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2561844 Tue, 30 Jun 2009 23:00:00 +0100 2561844 http://www.medworm.com/index.php?rid=2534938&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19557378%26dopt%3DAbstract We report on an accidental intoxication with cyclopentolate eye drops. A 90-year-old patient became confused and was admitted to the emergency department. His symptoms consisted of disorientation, ataxia, and psychomotor agitation. Similar cases have been described in the literature. With this case report we would like to draw attention to this little known differential diagnosis when confronted with confused patients. PMID: 19557378 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534938 Fri, 26 Jun 2009 23:00:00 +0100 2534938 http://www.medworm.com/index.php?rid=2534942&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19547946%26dopt%3DAbstract DISCUSSION: The German version of the IQCODE reliably discriminates cognitively intact persons from those suffering from MCI or cortical dementia, but not between different types of cortical dementia, such as AD and FTLD. The IQCODE is an efficient informant-rated screening instrument for the early diagnosis of cognitive decline and dementia. PMID: 19547946 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534942 Tue, 23 Jun 2009 23:00:00 +0100 2534942 http://www.medworm.com/index.php?rid=2534940&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19547947%26dopt%3DAbstract Authors: Erkwoh R, Huber G The term "raptus melancholicus" is rarely used in clinical or scientific discussions. There is a lack of data on frequency and attribution to psychiatric disorders. It is found more often in the older literature where authors write of detailed personal experiences with this malicious phenomenon, but the published information is isolated as well. Clinicians and forensic psychiatrists judge raptus melancholicus to represent a risk for suicidal attempts as it appears suddenly and unexpectedly, arising from a state of delayed and inhibited psychomotor motility. This enigma, which sounds quite paradoxical, requires a psychopathological explanation as offered here. The inclusion of forensic aspects suggests that raptus melancholicus is not such a rare entity. P... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534940 Tue, 23 Jun 2009 23:00:00 +0100 2534940 http://www.medworm.com/index.php?rid=2534944&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19543877%26dopt%3DAbstract Authors: Soyka M The use of medications to enhance performance in healthy individuals is increasingly being propagated even by neuroscientists under such colorful terms as"neuro-enhancement". A large number of medications, including psychostimulants have been advocated in this context. Recent data from the German health insurance company DAK indicate that a number of employees already take medications to fulfill their professional needs and enhance performance. The use of new drugs in the healthy has even been advocated by prominent neurobiologists in a commentary in a recent edition of Nature. There are a number of ethical objections to this use and there is an apparent risk of addiction. To date German psychiatrists have surprisingly not been outspoken on this issue. The author would... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534944 Sat, 20 Jun 2009 23:00:00 +0100 2534944 http://www.medworm.com/index.php?rid=2534946&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19543699%26dopt%3DAbstract We report here a case of cyberstalking and discuss available empirical data. Cyberstalking may cause psychological distress similar to that of real world stalking. The need for a scientific definition of cyberstalking and for future studies is presented. Since it is likely that psychiatrists will encounter victims of cyberstalking they should have knowledge of this phenomenon. PMID: 19543699 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534946 Fri, 19 Jun 2009 23:00:00 +0100 2534946 http://www.medworm.com/index.php?rid=2534950&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19536516%26dopt%3DAbstract Authors: Weig W A small subgroup of patients who access psychiatric care proves to be"difficult" in many respects. Characteristic features include excessive use of services that entail high costs, enormous problems involved in interacting with the professional staff and fellow patients, and a high complication rate. The central problems comprise noncompliance, aggressiveness, and highly disruptive behavior. Young men predominate and the diagnosis frequently consists of schizophrenic psychoses and cluster B personality disorders. There are often signs of organic brain impairment and substance abuse as well as various comorbid mental disorders.In addition to psychopharmacological and psychotherapeutic treatment options, social psychiatric approaches play a prominent role in satisfactory ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534950 Thu, 18 Jun 2009 23:00:00 +0100 2534950 http://www.medworm.com/index.php?rid=2534948&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19536517%26dopt%3DAbstract Authors: Kaiser R, Fingerle V Neuroborreliosis is easily diagnosed by means of clinical symptoms and laboratory findings. Guiding symptoms are radicular pain and pareses of the extremities and the facial nerve. There is a great number of further less frequently occurring neurological symptoms, which can be attributed to a borrelial infection only by appropriate investigations of the CSF. Radiculitis is cured adequately by oral doxycycline while symptoms of the central nervous system are probably better treated intravenously by ceftriaxone, cefotaxime or penicillin G. Post-Lyme syndrome is a diffuse description of non-specific complaints, which are not the explicit result of a former infection with B. burgdorferi. As further antibiotics do not help and the CSF is unremarkable in most pa... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534948 Thu, 18 Jun 2009 23:00:00 +0100 2534948 http://www.medworm.com/index.php?rid=2534954&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19533077%26dopt%3DAbstract Authors: Kölch M, Allroggen M, Fegert JM Off-label use is an ongoing problem in child and adolescent psychiatry. Except methylphenidate and atomoxetine for attention-deficit/hyperactivity disorder (ADHD), most substances used to treat children and adolescents with psychiatric disorders are prescribed off-label. In additional to aspects of drug safety and efficacy the widespread off-label use raises issues of liability in the case of adverse events. In Germany off-label use also poses problems of reimbursement by the health insurance. In the future we expect, driven by written request of the FDA, numerous new indications for novel antipsychotics in the USA for the treatment of so-called childhood bipolar disorders. Given another diagnostic framework in context in Europe, these so-c... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534954 Wed, 17 Jun 2009 23:00:00 +0100 2534954 http://www.medworm.com/index.php?rid=2534952&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19533078%26dopt%3DAbstract This article gives an overview of the diagnostic process for insomniac disorders. Furthermore, up to date neurobiological models of insomnia are discussed. PMID: 19533078 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534952 Wed, 17 Jun 2009 23:00:00 +0100 2534952 http://www.medworm.com/index.php?rid=2534962&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19506825%26dopt%3DAbstract Authors: Riemann D, Hajak G The administration of benzodiazepine receptor agonists for periods of 3-4 weeks can be considered as evidence based for the treatment of insomnia. The off-label treatment of insomnia with sedating antidepressants or antipsychotics up to now has been subjected to far less rigorous evidence-based testing. In the meantime several randomized double-blind placebo-controlled studies indicate the effectiveness of sedating antidepressants for insomnia. Alternative medical treatments like the administration of melatonin or valerian are characterized by a heterogeneous database. On the contrary, cognitive behavioural therapy for insomnia (including psycho-education, relaxation, stimulus control, sleep restriction, cognitive therapy) is supported by an extensive databa... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534962 Tue, 09 Jun 2009 23:00:00 +0100 2534962 http://www.medworm.com/index.php?rid=2534960&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19506826%26dopt%3DAbstract Authors: Pauli E, Stefan H The wide spectrum of comorbid mental disorders in epilepsy includes anxiety, affective as well as personality disorders and psychosis. While the prevalence of mental disorders in the general epilepsy population is reported to be 6%, for focal epilepsies, especially temporal lobe epilepsy, this rate is considerably higher and the numbers given in the literature range from 20 to 70%, of which anxiety and depression have the highest share.According to the diathesis-stress model pre-existing vulnerability factors, neurobiological factors, iatrogenic effects and psychosocial stress factors are individually of different significance in the development of mental disorders in epilepsy. Learned reactions in answer to psychosocial stress as well as structural and funct... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534960 Tue, 09 Jun 2009 23:00:00 +0100 2534960 http://www.medworm.com/index.php?rid=2534958&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19506827%26dopt%3DAbstract Authors: Hefner J, Csef H, Seufert J Kallmann syndrome is defined as a combination of isolated hypogonadotropic hypogonadism (IHH), hyposmia or anosmia and several optional neurological or anatomical particularities. The genetically caused illness affects mechanisms of neuronal migration, first of all concerning GnRH-producing neurons and those of the olfactory bulb.The first, nowadays rather seldom case, serves as an example of a patient suffering from grave, especially somatic symptoms of the disease. IHH, anosmia, eunuchoidism (physique, puerile voice, gynecomastia, micropenis, missing secondary sex characteristics) and distinct osteoporosis were verified.With the case of the second patient, late psychosexual sequelae of the syndrome are elucidated. The patient had been treated with... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534958 Tue, 09 Jun 2009 23:00:00 +0100 2534958 http://www.medworm.com/index.php?rid=2534956&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19506828%26dopt%3DAbstract CONCLUSIONS: IA developed as a result of social interactions during childhood long before alcohol dependence. The results point to an important effect of IA on the severity and acceleration of alcohol dependence. Therefore, it might be helpful to improve efforts in primary prevention and psychotherapy of alcohol dependence by considering the specific needs of subjects with an IA. PMID: 19506828 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534956 Tue, 09 Jun 2009 23:00:00 +0100 2534956 http://www.medworm.com/index.php?rid=2534964&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19499196%26dopt%3DAbstract Authors: Cording C, Saß H The German insurance law stipulates that in cases of suicide, life insurance providers are not obligated to pay within a restriction period of 3 years, except if it can be proven that the suicide was committed in a state that precludes the insured's ability to make free choices. The relevant psychiatric assessment criteria are identical with those of mental and volitional competence in general. However, a different profile of patients and other disorders are involved, mainly depressive syndromes, but also chronic alcoholism as well as schizophrenic and paranoid syndromes. The assessment has to be based on the legal concept of mental disorder, which is different from the current diagnostic classifications in psychiatry. Decisive psychopathological symptoms... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534964 Fri, 05 Jun 2009 23:00:00 +0100 2534964 http://www.medworm.com/index.php?rid=2535010&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19360386%26dopt%3DAbstract Authors: Hilker R, Benecke R, Deuschl G, Fogel W, Kupsch A, Schrader C, Sixel-Döring F, Timmermann L, Volkmann J, Lange M Deep brain stimulation (DBS) has been shown to be effective for levodopa-responsive symptoms and tremor in Parkinson's disease (PD). The subthalamic nucleus (STN) is the preferred target for most patients suffering from late stage motor complications of the disorder. STN DBS is superior to best medical treatment concerning the control of motor fluctuations and the increase of on-time without dyskinesias. In contrast to DBS of the internal pallidum (GPi), STN stimulation also permits a reduction of the dopaminergic medication. Long-term data demonstrated sustained effectiveness of STN DBS despite progressive disease. DBS of the thalamic ventral intermediate nucl... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535010 Sun, 31 May 2009 23:00:00 +0100 2535010 http://www.medworm.com/index.php?rid=2534996&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404601%26dopt%3DAbstract Authors: Dieterich M, Hamann GF PMID: 19404601 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534996 Sun, 31 May 2009 23:00:00 +0100 2534996 http://www.medworm.com/index.php?rid=2534992&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404603%26dopt%3DAbstract Authors: Sixel-Döring F, Benecke R, Fogel W, Hilker R, Kupsch A, Lange M, Schrader C, Timmermann L, Volkmann J, Deuschl G In Germany, deep brain stimulation (DBS) of the thalamic ventralis intermedius nucleus (VIM) is licensed for treatment of essential tremor in cases unresponsive to pharmacotherapy. Especially a bothersome hand tremor interfering with activities of daily living will improve, whereas head, tongue or vocal tremor shows less response. DBS was proven to be superior to lesional thalamotomy with better functional outcome and less adverse effects. The consensus statement presented here reflects the current recommendations of the German Deep Brain Stimulation Study Group for inclusion and exclusion criteria as well as for peri-, intra- and postoperative neurological man... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534992 Sun, 31 May 2009 23:00:00 +0100 2534992 http://www.medworm.com/index.php?rid=2534990&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404604%26dopt%3DAbstract Authors: Voges J, Kiening K, Krauss JK, Nikkhah G, Vesper J Surgery combining stereotactically guided implantation of brain electrodes in subcortical key structures of the brain with the connection of these brain electrodes to subcutaneously implanted impulse generators is one precondition for the therapeutic application of deep brain stimulation (DBS). During the last 10-15 years minimal requirements concerning this surgery have been formulated, addressing in particular technical equipment and operational procedures and being also in parts supported quantitatively by systematic investigations. Only appropriate patient management, high technical standards and an adequate surgical technique can minimize the frequency of those complications, which are supposed to be directly caused by su... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534990 Sun, 31 May 2009 23:00:00 +0100 2534990 http://www.medworm.com/index.php?rid=2534988&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404605%26dopt%3DAbstract Authors: Schrader C, Benecke R, Deuschl G, Hilker R, Kupsch A, Lange M, Sixel-Döring F, Timmermann L, Volkmann J, Fogel W Medical treatment of dystonia, particularly generalised forms of the disorder, is often not satisfactory or causes intolerable side effects. In focal dystonia, a reasonable treatment option with botulinum toxin exists but some patients either do not respond well or develop neutralising antibodies with secondary therapy failure. Deep brain stimulation (DBS) of the globus pallidus internus has been shown to be effective in both generalised and focal dystonia. This paper gives recommendations regarding the use of DBS in different forms of dystonia based on the currently available scientific data as well as the longstanding personal experience of the authors. The i... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534988 Sun, 31 May 2009 23:00:00 +0100 2534988 http://www.medworm.com/index.php?rid=2534980&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19458928%26dopt%3DAbstract Authors: Deuschl G PMID: 19458928 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534980 Sun, 31 May 2009 23:00:00 +0100 2534980 http://www.medworm.com/index.php?rid=2534978&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19458929%26dopt%3DAbstract Authors: Marx P PMID: 19458929 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534978 Sun, 31 May 2009 23:00:00 +0100 2534978 http://www.medworm.com/index.php?rid=2534976&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19468703%26dopt%3DAbstract Authors: Finsterer J The central nervous system (CNS) is the second most frequently affected organ in mitochondrial disorders (MD). In the majority of the cases, clinical CNS manifestations correlate with the CNS lesions on imaging and vice versa. The most important method to demonstrate CNS abnormalities in MD is the MRI. This imaging technique can demonstrate structural lesions, such as strokelike lesions, focal or diffuse atrophy, cysts or lacunas, focal or diffuse white matter lesions, grey matter lesions of the cortex or deep grey matter, and increased iron deposition. Functional abnormalities such as increased lactate in the white and grey matter or increased cholin in the white matter can be demonstrated by proton spectroscopy. Abnormlities of the intracerebral vessels can also ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534976 Sun, 31 May 2009 23:00:00 +0100 2534976 http://www.medworm.com/index.php?rid=2534972&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19471902%26dopt%3DAbstract Authors: Timmermann L, Deuschl G, Fogel W, Hilker R, Kupsch A, Lange M, Schrader C, Sixel-Döring F, Volkmann J, Benecke R Deep brain stimulation (DBS) in the nucleus ventralis intermedius thalami (VIM) is a common procedure to treat disabling tremor in multiple sclerosis which is refractory to pharmacological treatment. The sparse studies on DBS in multiple sclerosis tremor remain controversial regarding the clinical effect on postural and action tremor of hands, trunk and head. Furthermore, it remains unclear whether DBS in multiple sclerosis tremor is superior to thalamotomy and whether patients show an overall improvement in quality of life and activities of daily living. Therefore, the consensus recommendations of the German Deep Brain Stimulation Study Group rely primarily on... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534972 Sun, 31 May 2009 23:00:00 +0100 2534972 http://www.medworm.com/index.php?rid=2534936&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19557379%26dopt%3DAbstract Authors: Pauli E, Stefan H The wide spectrum of comorbid mental disorders in epilepsy includes anxiety, affective, and personality disorders and psychosis. While the prevalence of mental disorders in the general epileptic population is listed at 6%, this rate is considerably higher in focal epilepsies, especially temporal lobe epilepsy, and the numbers given in the literature range from 20% to 70%, of which anxiety and depression are the most prominent. According to the Diathesis Stress Model, the effects of previously existing vulnerability and neurobiologic, iatrogenic, and psychosocial stress factors vary in the development of mental disorders in epilepsy. Roles are also played by learned reactions in responce to psychosocial stress as well as structural and functional disturbances ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534936 Sun, 31 May 2009 23:00:00 +0100 2534936 http://www.medworm.com/index.php?rid=2534934&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19557380%26dopt%3DAbstract Authors: PMID: 19557380 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534934 Sun, 31 May 2009 23:00:00 +0100 2534934 http://www.medworm.com/index.php?rid=2534932&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19557381%26dopt%3DAbstract Authors: PMID: 19557381 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534932 Sun, 31 May 2009 23:00:00 +0100 2534932 http://www.medworm.com/index.php?rid=2534968&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19484213%26dopt%3DAbstract CONCLUSIONS: The Zurich CHP is a cost-efficient alternative to traditional inpatient treatment. Specifically, our results suggest that this type of acute crisis intervention should be established as a standard psychiatric care service. PMID: 19484213 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534968 Sat, 30 May 2009 23:00:00 +0100 2534968 http://www.medworm.com/index.php?rid=2534966&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19484214%26dopt%3DAbstract Authors: Kerkhoff G, Marquardt C Visually based reading disorders are frequently encountered in patients with acquired brain damage. Homonymous visual field defects, impaired elementary visual capacities (acuity, contrast sensitivity, convergent fusion, ocular motor disorders), visual neglect or Balint-Holmes syndrome are the most frequent causes of such reading disorders. Reading is not only an important prerequisite for vocational and private life, but is also indispensable for subsequent cognitive abilities such as verbal working memory and long-term memory. Despite this importance no comprehensive system exists for the standardised assessment and treatment of visually based reading capacities in the German-speaking area. Here, we describe the basic properties of such a system (READ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534966 Sat, 30 May 2009 23:00:00 +0100 2534966 http://www.medworm.com/index.php?rid=2534970&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19479196%26dopt%3DAbstract Authors: Neu P Stroke is the third leading cause of death, just after heart disease and cancer. Its incidence will probably increase dramatically in the coming decades. For prevention it is urgently necessary to gain fundamental knowledge about the risk factors and pathophysiological mechanisms. It is now widely accepted that depression and stroke are correlated with each other. There is little knowledge, however, about the links that might connect both diseases. This review discusses different mechanisms that lead to an increased stroke risk and can be influenced by depression as well thus possibly linking depression and stroke. PMID: 19479196 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534970 Fri, 29 May 2009 23:00:00 +0100 2534970 http://www.medworm.com/index.php?rid=2534974&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19471901%26dopt%3DAbstract CONCLUSIONS: Although methodological limitations have to be taken into account, our results suggest that QE provides better chances of treatment success than KE. PMID: 19471901 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534974 Wed, 27 May 2009 23:00:00 +0100 2534974 http://www.medworm.com/index.php?rid=2534982&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19455296%26dopt%3DAbstract CONCLUSION: In this feasibility study all antidepressive treatments were successfully implemented in the rehabilitation of post-stroke depressed patients. Combination therapy (interpersonal psychotherapy plus medication) was as effective as one of those elements alone. Because of the small sample size however, further randomized trials are required. PMID: 19455296 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534982 Wed, 20 May 2009 23:00:00 +0100 2534982 http://www.medworm.com/index.php?rid=2534984&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19455295%26dopt%3DAbstract Authors: Arends M, Fangerau H, Winterer G Deep brain stimulation is a novel and reversible surgical intervention in the treatment of psychiatric disorders. Recent studies in small samples of patients with depression and obsessive-compulsive disorder have come up with promising results. Neurosurgical interventions in psychiatric patients raise ethical questions in the context of historical experiences with traditional and irreversible psychosurgical procedures that need to be discussed. PMID: 19455295 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534984 Tue, 19 May 2009 23:00:00 +0100 2534984 http://www.medworm.com/index.php?rid=2535004&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19387602%26dopt%3DAbstract Authors: Möller HJ PMID: 19387602 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535004 Thu, 30 Apr 2009 23:00:00 +0100 2535004 http://www.medworm.com/index.php?rid=2535002&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19396417%26dopt%3DAbstract Authors: Rief W, Hofmann SG Although long-term psychoanalysis has been criticized due to lacking scientific efficacy, a meta-analysis by Leichsenring and Rabung concludes it is even more effective than other psychological interventions and follows a dose:response relationship (i.e. the longer the better). We reassessed this meta-analysis and find that its conclusions are not warranted. First, major parts of them are not based on the included randomised clinical trials (11) but on observational studies (12), which are known to be subject to investigator bias. The definition of long-term psychoanalysis included mainly randomised clinical trials with fewer than 50 treatment sessions, which is untypically short for this kind of intervention. Comparison groups were misclassified (especially... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535002 Thu, 30 Apr 2009 23:00:00 +0100 2535002 http://www.medworm.com/index.php?rid=2535000&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19396418%26dopt%3DAbstract Authors: Damm J, Eser D, Schüle C, Möller HJ, Rupprecht R, Baghai TC Core symptoms of depression are a combination of psychological and somatic symptoms, often associated with psychomotor and cognitive disturbances. The diagnostic classifications of depression include the concepts of melancholic, endogenous, or severe depression. All subgroups describe severely depressed patients suffering from most of the core symptoms of depression. In addition these patients exhibit the clinical characteristics of a recurrent unipolar or bipolar course, lower placebo response rates, or higher response rates to ECT, to antidepressant treatments with dually or mixed modes of action, or to lithium augmentation. Higher rates of HPA axis hyperactivity and specific EEG patterns may also occur in... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535000 Thu, 30 Apr 2009 23:00:00 +0100 2535000 http://www.medworm.com/index.php?rid=2534998&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19396419%26dopt%3DAbstract Authors: Hegerl U, Schönknecht P Minor depression, subsyndromal depression and subthreshold depression are frequent conditions in primary care which do not fulfil the criteria of a depressive disorder but are associated with functional disability, impairment of quality of life, and health care use. This paper reviews studies on the clinical evidence of pharmacotherapy, psychotherapy, and interventions to improve primary care. In this regard, whether clinical relevance of antidepressant therapies can be concluded from differences between placebo and active treatment is critically discussed. Due to lacking clinical evidence, aspects of a pragmatic therapeutic approach in those patients are presented. PMID: 19396419 [PubMed - in process] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534998 Thu, 30 Apr 2009 23:00:00 +0100 2534998 http://www.medworm.com/index.php?rid=2534986&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404606%26dopt%3DAbstract Authors: Berger M, Brakemeier EL, Klesse C, Schramm E The use of psychotherapeutic strategies is essential in the treatment of affective disorders. Psychotherapy proved to be at least equivalent to antidepressant medication in the treatment of mild to moderate depression. In severe cases, the combination of both treatments is considered by guidelines to be the standard treatment. Psychotherapeutic approaches show a longer latency than antidepressants; however, the effects are longer lasting. Regarding the effectiveness of pharmacotherapy sobering results have been published recently. Therefore, the further development of psychotherapy deserves special attention. Cognitive behavioral therapy and interpersonal therapy provide the highest evidence. The empirical basis for psychodynamic ps... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534986 Thu, 30 Apr 2009 23:00:00 +0100 2534986 http://www.medworm.com/index.php?rid=2534994&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19404602%26dopt%3DAbstract Authors: Kersting A, Schlicht S, Kroker K Internet therapy is directed toward people whose access to the usual treatment structures is limited. Further, Internet therapy is aimed at patients with circumscribed psychiatric disorders or symptoms. Compared to usual face-to-face treatment the duration of the Internet therapy programs evaluated were rather short, and frequently only small populations were examined. The studies presented demonstrate that Internet-based therapy of specific disorders is suitable for a significant reduction of symptoms. As follow-up data of longer duration are not available, no concluding statement relating to sustained symptom reduction can be made. Further, it remains unclear whether efficacy of the Internet therapy programs examined is comparable to usual tr... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2534994 Wed, 29 Apr 2009 23:00:00 +0100 2534994 http://www.medworm.com/index.php?rid=2535006&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384545%26dopt%3DAbstract Authors: Evangelidou E, Dengler R The brain stem consists of the mesencephalon, pons, and medulla oblongata and contains the nuclei of the cranial nerves III to XII, their complex connectivity, the ascending and descending fibre tracts, and the cerebellar connections. The corticobulbar and corticospinal tracts and the medial lemniscus cross its midline. Vital functions such as wakefulness, respiration, swallowing, and circulation are controlled there. Here we discuss acute brain stem syndromes of vascular, inflammatory, and toxic-metabolic origin. They present frequently with alternating symptoms, i.e. ipsilateral cranial nerve deficits associated with contralateral signs of long-fibre tract involvement and with various disturbances of the oculomotor system. Modern diagnostic and thera... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535006 Tue, 21 Apr 2009 23:00:00 +0100 2535006 http://www.medworm.com/index.php?rid=2535008&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19367384%26dopt%3DAbstract Authors: Rosenberg-Nordmann M, Berthele A, Tölle TR, Sprenger T Trigeminal autonomic cephalgias (TAC) are classified as primary headache syndromes. The use of instrumental procedures including neuroimaging in the diagnostic workup of the TACs is controversially discussed in the literature. Several case reports have been previously published, reporting trigeminal autonomic cephalgias related to structural lesions. We contribute two of our own cases of symptomatic TACs and demonstrate that a "classic" clinical presentation does not preclude a symptomatic etiology. Thus, we advocate a systematic diagnostic evaluation including neuroimaging in every patient presenting with symptoms indicative of TAC for the first time. PMID: 19367384 [PubMed - as supplied by publisher] (Source: De... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535008 Wed, 15 Apr 2009 23:00:00 +0100 2535008 http://www.medworm.com/index.php?rid=2535012&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19360385%26dopt%3DAbstract Authors: Hornyak M, Benes H, Eisensehr I, Haan J, Kassubek J, Peglau I, Stiasny-Kolster K, Trenkwalder C Depressive disorders are a prevalent comorbidity in restless legs syndrome (RLS). Although similar prevalence rates of comorbid depression can be found in other diseases, the association between RLS and depression is particularly complex due to the RLS-related sleep disorders. It is also clinically important that according to findings derived mainly from case studies many antidepressant agents can aggravate RLS symptoms. The presence of comorbid depression influences therapy outcome in general and should therefore be taken into account. So far, there is no evidence-based systematic research concerning diagnosis and treatment process, and no recommendations exist for the treatment of... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535012 Fri, 10 Apr 2009 23:00:00 +0100 2535012 http://www.medworm.com/index.php?rid=2535016&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19357826%26dopt%3DAbstract Authors: Hartung HP, Warnke C, Hohlfeld R, Kieseier BC As new cases arise of progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis (MS) treated with the monoclonal antibody natalizumab, a critical discussion about risks and advantages of this specific kind of immunotherapy appears necessary. Practical consequences and treatment options are addressed based on current concepts of PML's pathogenesis in patients treated with natalizumab. Critical patient selection based on risk:benefit considerations, limited therapy regimens, early diagnosis of PML by clinical and paraclinical criteria, and therapeutic perspectives for treating PML are discussed. The risk of PML in patients with MS needs to be continually monitored and should be reduced with all means availa... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535016 Thu, 09 Apr 2009 23:00:00 +0100 2535016 http://www.medworm.com/index.php?rid=2535014&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19357827%26dopt%3DAbstract We report on two patients with acute positional vertigo due to nodular infarction, a clinical presentation is not reported so far. High-resolution MR imaging using thin slices is required to identify isolated nodular infarctions. PMID: 19357827 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2535014 Thu, 09 Apr 2009 23:00:00 +0100 2535014 http://www.medworm.com/index.php?rid=2310968&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19347262%26dopt%3DAbstract Authors: PMID: 19347262 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2310968 Sun, 05 Apr 2009 04:00:00 +0100 2310968 http://www.medworm.com/index.php?rid=2310966&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19347263%26dopt%3DAbstract Authors: Seiler R, Hamann GF PMID: 19347263 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2310966 Sun, 05 Apr 2009 04:00:00 +0100 2310966 http://www.medworm.com/index.php?rid=2310961&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19347264%26dopt%3DAbstract We report the case of a patient with thymoma showing myasthenia gravis as well as polymyositis. Due to the simultaneous occurrence of these paraneoplastic diseases, the criteria for exact diagnosis (serum creatine kinase, EMG, ocular involvement) overlap. This diagnostic dilemma can appreciably complicate the therapeutic approach. PMID: 19347264 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2310961 Sun, 05 Apr 2009 04:00:00 +0100 2310961 http://www.medworm.com/index.php?rid=2310976&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19340405%26dopt%3DAbstract Authors: Reichel G, Stenner A This is the first report about successful botulinum toxin therapy of the intrinsic muscles of the tongue in two patient with lingual dystonias. In these patients botulinum toxin was injected direct into the tongue. PMID: 19340405 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2310976 Fri, 03 Apr 2009 04:00:00 +0100 2310976 http://www.medworm.com/index.php?rid=2310974&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19340406%26dopt%3DAbstract Authors: Bürgy M The accomplishments of Heidelberg psychopathology and their continued development are illustrated using the example of the concept of psychosis. Jaspers founded the Heidelberg school by methodologically collating the psychiatric knowledge of his time in a structured fashion and in doing so laid the foundation for modern nosology. While, however, ICD and DSM classifications tend to be modelled on symptoms of expression and behaviour, the phenomenological models which Jaspers introduced into the field of psychiatry rather focused on symptoms of subjective experience. The phenomenological developments of psychopathology which originated in this context are, in the case of the schizophrenic psychoses, presented in a kaleidoscope-like manner. It becomes evident that a ... Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2310974 Fri, 03 Apr 2009 04:00:00 +0100 2310974 http://www.medworm.com/index.php?rid=2310970&cid=s_36790_25_f&fid=36790&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19343316%26dopt%3DAbstract CONCLUSION: The recommendations for renewing walking ability in chronic stroke patients are considerable. Therefore the emphasis of physiotherapy should be on increasing walking speed and endurance. PMID: 19343316 [PubMed - as supplied by publisher] (Source: Der Nervenarzt) Der Nervenarzt journals http://www.medworm.com/rss/comments.php?id=2310970 Fri, 03 Apr 2009 04:00:00 +0100 2310970