MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diabetes Metab' source. Wed, 08 Feb 2012 15:08:53 +0100 http://www.medworm.com/index.php?rid=5626442&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22247907%26dopt%3DAbstract Authors: Kim WJ, Park CY PMID: 22247907 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=5626442 Thu, 01 Dec 2011 05:00:00 +0100 5626442 http://www.medworm.com/index.php?rid=5626441&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22247908%26dopt%3DAbstract Authors: Chung JO, Cho DH, Chung DJ, Chung MY PMID: 22247908 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=5626441 Thu, 01 Dec 2011 05:00:00 +0100 5626441 http://www.medworm.com/index.php?rid=5495973&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115993%26dopt%3DAbstract CONCLUSION: Diabetes was associated with 4-year mortality after adjusting for the inverse relationship between mortality and BMI. This association was better accounted for by the global comorbidity load and functional disabilities than by the individual vascular comorbidities. These findings suggest that the active management of all - rather than selected - comorbidities is the key to improving the prognosis for older diabetic patients. PMID: 22115993 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=5495973 Tue, 22 Nov 2011 05:00:00 +0100 5495973 http://www.medworm.com/index.php?rid=5446477&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22111049%26dopt%3DAbstract Authors: Ko SH, Ko SH PMID: 22111049 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=5446477 Sat, 01 Oct 2011 04:00:00 +0100 5446477 http://www.medworm.com/index.php?rid=5301987&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21977464%26dopt%3DAbstract Authors: Kim CH PMID: 21977464 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=5301987 Mon, 01 Aug 2011 04:00:00 +0100 5301987 http://www.medworm.com/index.php?rid=5301986&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21977465%26dopt%3DAbstract Authors: Kim JH, Oh SJ, Lee JM, Hong EG, Yu JM, Han KA, Min KW, Son HS, Chang SA PMID: 21977465 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=5301986 Mon, 01 Aug 2011 04:00:00 +0100 5301986 http://www.medworm.com/index.php?rid=4970396&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21681003%26dopt%3DAbstract Authors: Rendell M, Chrysant SG Original article: Taskinen MR, Rosenstock J, Tamminen I, et al. Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab. 2011;13(1):65-74. PRACTICE PEARL: This trial in patients with type 2 diabetes inadequately controlled on metformin demonstrated the efficacy of adding linagliptin 5 mg once daily; this novel dipeptidyl peptidase-4 inhibitor significantly improved glycemic control without weight gain or increased risk of hypoglycemia. PMID: 21681003 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4970396 Mon, 27 Jun 2011 18:00:27 +0100 4970396 http://www.medworm.com/index.php?rid=4970397&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21671256%26dopt%3DAbstract Authors: Harashima SI, Wang Y, Horiuchi T, Seino Y, Inagaki N Purkinje cell protein 4 (PCP4), also called brain-specific polypeptide 19 (PEP19), is a neurospecific, small calmodulin-binding protein that binds both calcium-free and calcium-binding calmodulin to regulate the calmodulin-mediated signal. The expression level of this molecule is decreased in the brain in Alzheimer's disease, Huntington's disease, and alcoholism. However, little is known of the function of PCP4 regarding neuronal or neuroendocrine cell differentiation and neurotransmitter release. To address this, we established a PCP4 tetracycline-inducible rat chromaffin cell line, PC12. When PCP4 expression was induced with doxcycline, neurite outgrowth was significantly advanced in the presence of nerve growth factor (NG... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4970397 Thu, 09 Jun 2011 23:00:00 +0100 4970397 http://www.medworm.com/index.php?rid=4720553&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21493117%26dopt%3DAbstract CONCLUSION: In this study, the main therapeutic goals of insulin therapy, as defined by the Afssaps/HAS 2006 guidelines, were only attained in around 20% of type 2 diabetic patients, irrespective of follow-up by a GP or DT. During consultation, insulin therapy was not optimalized in a large proportion of inadequately controlled patients. PMID: 21493117 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4720553 Mon, 11 Apr 2011 23:00:00 +0100 4720553 http://www.medworm.com/index.php?rid=4720555&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21489843%26dopt%3DAbstract CONCLUSION: This study demonstrates that a low-cost, moderate-intensity, individual interdisciplinary approach combined with group seminars leads to clinically significant weight loss and metabolic improvement in people with prediabetes. Group seminars alone were not effective in this population (www.ClinicalTrial.gov, Identifier: NCT00991549). PMID: 21489843 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4720555 Sun, 10 Apr 2011 23:00:00 +0100 4720555 http://www.medworm.com/index.php?rid=4720554&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21489844%26dopt%3DAbstract CONCLUSION: In our population, a two-step screening strategy for GDM was neither relevant nor efficient. It could be simplified with a single-step definitive screening strategy using a 75-g OGTT, as used in the HAPO study, and as recommended by the IADPSG and the recent French Expert Consensus. At present, there are still no evidence-based arguments to help in deciding between selective or universal screening for GDM. PMID: 21489844 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4720554 Sun, 10 Apr 2011 23:00:00 +0100 4720554 http://www.medworm.com/index.php?rid=4720556&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21478041%26dopt%3DAbstract CONCLUSION: This study confirms the importance of Ramadan fasting for Muslim patients, and reveals a wide cross-cultural gap between GPs and their patients. Systematic advice on treatment adjustment needs to be given. For this reason, we encourage more sensitive care of these patients and more medical training for physicians. PMID: 21478041 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4720556 Wed, 06 Apr 2011 23:00:00 +0100 4720556 http://www.medworm.com/index.php?rid=4720557&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21474360%26dopt%3DAbstract CONCLUSION: In pregnant patients with type 1 diabetes, MDI and CSII are equivalent in terms of metabolic control and fetal-maternal outcomes, although patients using CSII achieved good control earlier and with less insulin. PMID: 21474360 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4720557 Mon, 04 Apr 2011 23:00:00 +0100 4720557 http://www.medworm.com/index.php?rid=4720558&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21459647%26dopt%3DAbstract CONCLUSION: Prediabetes is related to the presence of several indicators of end-organ damage in white subjects, but not in blacks or Hispanics. Further longitudinal investigations into disease risks related to prediabetes in different ethnic groups are also needed. PMID: 21459647 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4720558 Thu, 31 Mar 2011 23:00:00 +0100 4720558 http://www.medworm.com/index.php?rid=4720559&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21458350%26dopt%3DAbstract CONCLUSION: Chinese type 2 diabetic patients taking OHAs had more negative beliefs and attitudes towards insulin therapy than patients being treated with insulin. This difference was not associated with either gender or education level. Furthermore, neither injection duration nor type of device was related to perception of insulin therapy. PMID: 21458350 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4720559 Tue, 29 Mar 2011 23:00:00 +0100 4720559 http://www.medworm.com/index.php?rid=4356345&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21170474%26dopt%3DAbstract Authors: Galán M, García-Herrero CM, Azriel S, Gargallo M, Durán M, Gorgojo JJ, Andía VM, Navas MA Hepatocyte nuclear factor 1-alpha (HNF-1α) is a homeodomain transcription factor expressed in a variety of tissues, including liver and pancreas, which regulates a wide range of genes. Heterozygous mutations in the gene encoding HNF-1α (HNF1A) cause familial young onset diabetes, also known as Maturity-Onset Diabetes of the Young type 3 (MODY3). The variability of the MODY3 clinical phenotype can be due to environmental and genetic factors as well as to the type and position of mutations. Thus, functional characterization of HNF1A mutations might provide insights into the molecular defects explaining the variability of MODY3 phenotype. We have functionally characterized six HNF1A mu... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356345 Wed, 15 Dec 2010 00:00:00 +0100 4356345 http://www.medworm.com/index.php?rid=4356362&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163415%26dopt%3DAbstract Authors: Vambergue A PMID: 21163415 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356362 Wed, 01 Dec 2010 00:00:00 +0100 4356362 http://www.medworm.com/index.php?rid=4356361&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163416%26dopt%3DAbstract Authors: Vayssière C, Grandjean H Reminder of the aim of clinical practice recommendations (CPR). The ever more rapid development of new techniques and the diffusion of large amounts of information in the medical literature make it difficult for clinicians to assimilate and synthesize everything, giving rise to major variations in practices that are sometimes inappropriate or even unnecessary. This situation has led several countries to establish recommendations for treatment, diagnosis, prevention methods and disease care. These recommendations aim to help clinicians in decision-making by offering a synthesis with a certain level of scientific proof or professional consensus. PMID: 21163416 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356361 Wed, 01 Dec 2010 00:00:00 +0100 4356361 http://www.medworm.com/index.php?rid=4356360&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163417%26dopt%3DAbstract Authors: Garabedian C, Deruelle P To provide management guidelines for labour and delivery in women with gestational diabetes. PMID: 21163417 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356360 Wed, 01 Dec 2010 00:00:00 +0100 4356360 http://www.medworm.com/index.php?rid=4356359&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163418%26dopt%3DAbstract Authors: Beucher G, Viaris de Lesegno B, Dreyfus M To estimate maternal outcome of treated or untreated gestational diabetes mellitus (GDM). PMID: 21163418 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356359 Wed, 01 Dec 2010 00:00:00 +0100 4356359 http://www.medworm.com/index.php?rid=4356358&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163419%26dopt%3DAbstract Authors: Cosson E To answer two questions: is there a threshold for pathological hyperglycaemia after 24 weeks of gestation? What are the diagnostic criteria for gestational diabetes mellitus? PMID: 21163419 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356358 Wed, 01 Dec 2010 00:00:00 +0100 4356358 http://www.medworm.com/index.php?rid=4356357&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163420%26dopt%3DAbstract Authors: Virally M, Laloi-Michelin M The aim of this review is to provide answers to the question “How does one screen for and diagnose gestational diabetes mellitus (GDM) between 24 and 28 weeks gestation?” Two methods are currently widely used: a one-step approach (the 75g-Oral Glucose Tolerance Test, OGTT) and a two-step approach (the 50g Glucose Challenge Test, GCT, followed by 100g-OGTT). A review of the literature showed that both methods had good reproducibility (around 80%), whilst neither required preliminary diet changes. The data of the Hyperglycaemia Adverse Pregnancy Outcomes (HAPO) study on materno-foetal morbidity provided consistent support in favour of the 75g-OGTT. In addition, this one-step method presents several advantages over the two-step method, i.e. it prov... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356357 Wed, 01 Dec 2010 00:00:00 +0100 4356357 http://www.medworm.com/index.php?rid=4356356&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163421%26dopt%3DAbstract Authors: Kerlan V Women who have had gestational diabetes mellitus must be monitored in the immediate postpartum period to ensure that blood glucose levels return to normal without further treatment. In the few studies performed specifically in these women, those that breastfed did not have a different metabolic profile, at least during the period of breastfeeding; the metabolic profiles of children born to women that had gestational diabetes and that breastfed also did not differ from those that were not breastfed. The choice of contraception must mainly take into consideration the associated risk factors. The studies, even if few have specifically focused on women with a history of gestational diabetes, have not demonstrated a significant disturbance of glucose metabolism while using... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356356 Wed, 01 Dec 2010 00:00:00 +0100 4356356 http://www.medworm.com/index.php?rid=4356355&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163422%26dopt%3DAbstract Authors: Hiéronimus S, Le Meaux JP To assess the relevance of gestational diabetes mellitus (GDM) screening policies and to compare selective with universal screening. PMID: 21163422 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356355 Wed, 01 Dec 2010 00:00:00 +0100 4356355 http://www.medworm.com/index.php?rid=4356354&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163423%26dopt%3DAbstract Authors: Mitanchez D To evaluate the modalities of neonatal care for cases of treated and untreated gestational diabetes mellitus (GDM). PMID: 21163423 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356354 Wed, 01 Dec 2010 00:00:00 +0100 4356354 http://www.medworm.com/index.php?rid=4356353&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163424%26dopt%3DAbstract Authors: Verier-Mine O Women with a history of gestational diabetes mellitus (GDM) are characterized by a high risk of type 2 diabetes mellitus (T2DM) (x 7), metabolic syndrome (x 2 to 5) and cardiovascular diseases (x 1,7). Women with lesser degrees of glucose intolerance share the same risks. T2DM may occur from post-partum (5 to 14%) to several years later, up to 25 years. Some factors associated with T2DM are identified: obesity, early diagnosis of GDM before 24 weeks gestation, high pregnancy OGTT blood glucose or insulin-therapy during GDM. Screening for T2DM only with fasting glucose provides less sensibility than with OGTT; HbA1c may supplant these dosages. The recurrence rate of GDM is between 30 and 84%, non-white ethnicity and insulinotherapy during GDM being the best proven... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356353 Wed, 01 Dec 2010 00:00:00 +0100 4356353 http://www.medworm.com/index.php?rid=4356352&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163425%26dopt%3DAbstract Authors: Mitanchez D To evaluate the risks of perinatal complications in infants born to mothers with treated or untreated gestational diabetes mellitus (GDM). PMID: 21163425 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356352 Wed, 01 Dec 2010 00:00:00 +0100 4356352 http://www.medworm.com/index.php?rid=4356351&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163426%26dopt%3DAbstract Authors: Galtier F Gestational diabetes mellitus is defined as glucose intolerance that begins or is first recognized during pregnancy. Its prevalence, generally situated between 2-6%, may reach 10-20% in high-risk populations, with an increasing trend across most racial/ethnic groups studied. Among traditional risk factors, previous gestational diabetes, advanced maternal age and obesity have the highest impact on gestational diabetes risk. Racial/ethnic origin and family history of type 2 diabetes have a significant but moderate impact (except for type 2 diabetes in siblings). Several non traditional factors have been recently characterized, either physiological (low birthweight and short maternal height) or pathological (polycystic ovaries). The multiplicity of risk factors and thei... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356351 Wed, 01 Dec 2010 00:00:00 +0100 4356351 http://www.medworm.com/index.php?rid=4356350&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163427%26dopt%3DAbstract Authors: Guedj AM To consider the arguments for screening outside the standard screening period of 24 to 28 weeks of gestation. PMID: 21163427 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356350 Wed, 01 Dec 2010 00:00:00 +0100 4356350 http://www.medworm.com/index.php?rid=4356349&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163428%26dopt%3DAbstract Authors: Jacqueminet S, Jannot-Lamotte MF Maternal and perinatal complications linked to gestational diabetes mellitus could be decreased with an intensive management approach. PMID: 21163428 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356349 Wed, 01 Dec 2010 00:00:00 +0100 4356349 http://www.medworm.com/index.php?rid=4356348&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163429%26dopt%3DAbstract Authors: Thiebaugeorges O, Guyard-Boileau B To investigate data enabling the development of guidelines for obstetrical monitoring and management of the threat of preterm labour in gestational diabetes. PMID: 21163429 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356348 Wed, 01 Dec 2010 00:00:00 +0100 4356348 http://www.medworm.com/index.php?rid=4356347&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163430%26dopt%3DAbstract Authors: Burguet A To assess the long-term outcomes (type 2 diabetes, overweight, cardiovascular disorders, metabolic syndrome and neurological manifestations) from human epidemiological studies of foetuses exposed to gestational diabetes. PMID: 21163430 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356347 Wed, 01 Dec 2010 00:00:00 +0100 4356347 http://www.medworm.com/index.php?rid=4356346&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21163431%26dopt%3DAbstract Authors: PMID: 21163431 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4356346 Wed, 01 Dec 2010 00:00:00 +0100 4356346 http://www.medworm.com/index.php?rid=4205621&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21094464%26dopt%3DAbstract CONCLUSION: The stability of BID over 1year, with values close to 0.3IU/kg/day associated with a trend towards improvement in HbA(1c), reduction in the frequency of mild hypoglycaemic episodes and absence of major weight gain, supports the relevance of FIT educational training. PMID: 21094464 [PubMed - in process] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4205621 Mon, 01 Nov 2010 00:00:00 +0100 4205621 http://www.medworm.com/index.php?rid=4001599&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20864372%26dopt%3DAbstract CONCLUSION: This pilot observational study supports the hypothesis that CGM use can significantly improve overall glucose control while reducing hypoglycaemic episodes in hypoglycaemia-prone type 1 diabetic patients treated by CSII. PMID: 20864372 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4001599 Mon, 20 Sep 2010 23:00:00 +0100 4001599 http://www.medworm.com/index.php?rid=4001600&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20863735%26dopt%3DAbstract CONCLUSION: Confirming results already observed in diabetic adults, the present findings show, for the first time, that children who have difficulties in expressing their feelings to others are more at risk of poor glycaemic control. In future, it will be useful to identify the diabetic young people who have such difficulties and to consider interventions designed specifically for them. PMID: 20863735 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4001600 Sun, 19 Sep 2010 23:00:00 +0100 4001600 http://www.medworm.com/index.php?rid=4001601&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20851652%26dopt%3DAbstract CONCLUSION: The development of molecules targeting different inflammatory mechanisms could lead in diabetic patients to improvement of both glycaemia and cardiovascular prognosis. PMID: 20851652 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=4001601 Thu, 16 Sep 2010 23:00:00 +0100 4001601 http://www.medworm.com/index.php?rid=3913411&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20738877%26dopt%3DAbstract Authors: Levy J, Cobas RA, Gomes MB ABSTRACT: Since publication of our article [Diabetol Metab Syndr 2010, 2:16], we have noticed that amendments to the second sentence of the "Study Design" section are required as this should read as follows: "Approved by the local ethics committee, patient enrolment was restricted to the following patients: those aged 18 years and greater and taking immediate release metformin alone or in combination with other oral agents, those excluded had symptoms of poor diabetes control , were pregnant, had serum creatinine levels >1.3 mg/dL (female) or 1.4 mg/dL (male), nephropathy, evidence of hepatic disease or history of alcohol abuse." We apologize for any inconvenience or confusion that this may have caused. PMID: 20738877 [PubMed - as supplied by ... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3913411 Tue, 24 Aug 2010 23:00:00 +0100 3913411 http://www.medworm.com/index.php?rid=3867149&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20692197%26dopt%3DAbstract Authors: Brindisi MC, Bouillet B, Vergès B, Halimi S Although the issue of cardiovascular complications in type 2 diabetic patients is widely discussed, and recommendations for such screening are available, it is less common to do so for type-1 diabetes. Yet, independent of age, the mortality rate due to ischaemic cardiac disease is higher among type 1 diabetic patients (both male and female) than in the general population. Type 1 diabetic patients have certain specific characteristics related not only to atherosclerotic plaque and cardiovascular risk factors, but also to their capacity for physical activity and to the prevention of cardiovascular complications induced by hypoglycaemia. PMID: 20692197 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3867149 Wed, 04 Aug 2010 23:00:00 +0100 3867149 http://www.medworm.com/index.php?rid=3727372&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20598606%26dopt%3DAbstract CONCLUSION: Exenatide leads to long-term improvement of glycaemic control as well as weight loss in a majority of patients not responding to combined oral drug therapy in real-world clinical practice. However, no baseline factors predictive of response could be identified. Exenatide can be considered an effective treatment option in such patients, including those with high baseline HbA(1c) and long duration of diabetes. PMID: 20598606 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3727372 Tue, 29 Jun 2010 23:00:00 +0100 3727372 http://www.medworm.com/index.php?rid=3727371&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20598607%26dopt%3DAbstract CONCLUSION: These findings in a large cohort of Italian women with IGH confirm the detrimental effect of even minimally altered glucose tolerance on fetal outcome. Also, prepregnancy obesity plays an important role in raising the risk of adverse perinatal outcomes in such patients. PMID: 20598607 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3727371 Tue, 29 Jun 2010 23:00:00 +0100 3727371 http://www.medworm.com/index.php?rid=3727370&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20598608%26dopt%3DAbstract CONCLUSION: With increasing HbA(1c), there was a decrease in the contribution of postprandial hyperglycaemia to total glycaemia, and fasting hyperglycaemia became more important. This is consistent with impaired insulin release, particularly first-phase release, at higher HbA(1c) levels. PMID: 20598608 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3727370 Tue, 29 Jun 2010 23:00:00 +0100 3727370 http://www.medworm.com/index.php?rid=3727373&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20594891%26dopt%3DAbstract CONCLUSION: Non-diabetic hyperglycaemia, assessed either categorically by fasting glucose categories or continuously by HbA(1c) levels, correlates with the poorest angiographic outcomes. PMID: 20594891 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3727373 Mon, 28 Jun 2010 23:00:00 +0100 3727373 http://www.medworm.com/index.php?rid=3696294&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20570542%26dopt%3DAbstract CONCLUSION: While CAPN10 UCSNP-19 SNP and haplotype 111 contribute to the risk of T2DM in Tunisian subjects, no significant association between CAPN10 diplotypes and T2DM was demonstrated. PMID: 20570542 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3696294 Thu, 03 Jun 2010 23:00:00 +0100 3696294 http://www.medworm.com/index.php?rid=3696293&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20570543%26dopt%3DAbstract Authors: Molines L, Darmon P, Raccah D Charcot neuro-osteoarthropathy (CNO) is one of the more devastating complications affecting diabetic patients with peripheral and/or autonomic neuropathy. The acute phase of the disease is often misdiagnosed, and can rapidly lead to deformity and amputation. The rapid progression towards foot deformation calls for early detection and intervention. Classical neurotraumatic and neurotrophic theories fail to explain all of the features of the condition, although recent advances that have clarified the mechanisms underlying the pathophysiology may make up for this lack. In particular, new data have emerged on the central role of the RANK/RANK-ligand (RANK-L)/osteoprotegerin (OPG) system in the pathogenesis of osteopenia. Also, it is now recognized tha... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3696293 Thu, 03 Jun 2010 23:00:00 +0100 3696293 http://www.medworm.com/index.php?rid=3574200&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20474066%26dopt%3DAbstract Authors: Kazda C, Slieker L, Ilag L, Byrd R, Rees T, Prince M Interest in mitogenic and potentially carcinogenic effects of insulin and insulin analogues has been renewed by several recent publications that have examined the relationship between cancer and insulin analogues. Actions mediated through the insulin-like growth factor-I receptor in a hyperinsulinaemic state have been implicated mechanistically. Both type 2 diabetes and endogenously elevated insulin-like growth factor-I have been epidemiologically linked to malignancies. Therefore, in vitro mitogenic effects and binding affinities of the various analogues have been analysed. A recent publication by Weinstein et al. studied the in vitro mitogenic and anti-apoptotic activities of insulin analogues, and their conclusion asserts... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3574200 Mon, 01 Mar 2010 00:00:00 +0100 3574200 http://www.medworm.com/index.php?rid=3280632&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153675%26dopt%3DAbstract Authors: Thielen V, Place J, Gerbaud S, Scheen A, Bringer J, Renard E PMID: 20153675 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3280632 Thu, 11 Feb 2010 00:00:00 +0100 3280632 http://www.medworm.com/index.php?rid=3280631&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153676%26dopt%3DAbstract CONCLUSION: Levels of total plasma adiponectin are not useful for predicting long-term cardiovascular events in middle-aged men, but are strongly associated with glucose metabolism and markers of insulin resistance. PMID: 20153676 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3280631 Thu, 11 Feb 2010 00:00:00 +0100 3280631 http://www.medworm.com/index.php?rid=3232306&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19734081%26dopt%3DAbstract CONCLUSION: The new index proposed by Bastard et al. is as good a predictor of IS in sedentary men as the other commonly used indices, and appears to be as reliable in this population as it was in the original study of postmenopausal women. PMID: 19734081 [PubMed - indexed for MEDLINE] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=3232306 Sun, 01 Nov 2009 00:00:00 +0100 3232306 http://www.medworm.com/index.php?rid=2955583&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19879789%26dopt%3DAbstract CONCLUSION: Hyperuricaemia is independently associated with hepatic steatosis regardless of BMI category or the presence of the MetS in Korean adults. Further research into the causal relationship is needed. PMID: 19879789 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2955583 Thu, 29 Oct 2009 00:00:00 +0100 2955583 http://www.medworm.com/index.php?rid=2955580&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19879790%26dopt%3DAbstract CONCLUSION: Early-stage atherosclerosis is present in newly diagnosed, untreated T2DM and IGT patients, and it may be that its early assessment, along with good control of hypertension and hyperglycaemia, will help to delay its progression. PMID: 19879790 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2955580 Thu, 29 Oct 2009 00:00:00 +0100 2955580 http://www.medworm.com/index.php?rid=2654805&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19638694%26dopt%3DAbstract Authors: Saito M Collagen cross-links play important roles in the expression of bone strength and the proper biological function of bone. The cross-links of collagen can be roughly divided into two types : lysyl oxidase mediated cross-links (enzymatic immature and mature cross-links) and advanced glycation end-products (AGEs ; nonenzymatic cross-links, pentosidine) . Recently, we show that reduction in enzymatic cross-links and excessive formation of nonenzymatic crossl-links, pentosidine in bone could be important for explaining the variation of fracture susceptibility in osteoporosis (Osteoporos Int 17 (7) : 986-995, 2006) and diabetes (Osteoporos Int 17 (10) : 1514-1523, 2006) . We also demonstrate that urinary excretion AGEs cross-link, pentosidine is a novel risk for future verteb... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2654805 Fri, 31 Jul 2009 08:40:05 +0100 2654805 http://www.medworm.com/index.php?rid=2571335&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19574633%26dopt%3DAbstract Authors: Conlan AR, Paddock ML, Axelrod HL, Cohen AE, Abresch EC, Wiley S, Roy M, Nechushtai R, Jennings PA A primary role for mitochondrial dysfunction is indicated in the pathogenesis of insulin resistance. A widely used drug for the treatment of type 2 diabetes is pioglitazone, a member of the thiazolidinedione class of molecules. MitoNEET, a 2Fe-2S outer mitochondrial membrane protein, binds pioglitazone [Colca et al. (2004), Am. J. Physiol. Endocrinol. Metab. 286, E252-E260]. The soluble domain of the human mitoNEET protein has been expressed C-terminal to the superfolder green fluorescent protein and the mitoNEET protein has been isolated. Comparison of the crystal structure of mitoNEET isolated from cleavage of the fusion protein (1.4 A resolution, R factor = 20.2%) with other s... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2571335 Tue, 30 Jun 2009 23:00:00 +0100 2571335 http://www.medworm.com/index.php?rid=2533174&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19361968%26dopt%3DAbstract CONCLUSIONS: Clusters of metabolic abnormalities resembling phenotypes of metabolic syndrome are related to greater initial ECG LVH in hypertensive patients with value of blood pressure similar to individuals without metabolic abnormalities, and are associated with less reduction of ECG LVH during antihypertensive therapy, potentially contributing to the reported adverse prognosis of metabolic syndrome. PMID: 19361968 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2533174 Tue, 07 Apr 2009 23:00:00 +0100 2533174 http://www.medworm.com/index.php?rid=2288139&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19300897%26dopt%3DAbstract Authors: Manarte LF, Dias S, Góis C, Boavida JM Diabetes has been associated with depression since Thomas Willis' work in 1684 (Rubin and Peyrot in Diabetes Metab Rev 18:173-175, 2002). The aim of this study is to identify social and clinical factors independently associated with depression in individuals with type 1 diabetes. We carried out a descriptive transversal study with 110 type 1 diabetes patients, administered a questionnaire and obtained demographical and diabetes-related data (number of years from diagnosis, initial admission at diagnosis, glycated hemoglobin, number of complications, insulin dose, number of insulin injections per day, admission for ketoacidosis or hypoglycemia at diagnosis, and specific diabetes complications such as nephropathy, retinopathy, peripher... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2288139 Fri, 20 Mar 2009 04:00:00 +0100 2288139 http://www.medworm.com/index.php?rid=2248537&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19264524%26dopt%3DAbstract Authors: Sebbagh N, Cruciani-Guglielmacci C, Ouali F, Berthault MF, Rouch C, Sari DC, Magnan C Citrullus colocynthis (colocynth) seeds are traditionally used as antidiabetic medication in Mediterranean countries. The present study evaluated the differential effects of diets enriched with C. colocynthis, sunflower or olive oils on the pancreatic beta-cell mass in streptozotocin (STZ)-induced diabetes in rats. STZ injection induced rapid hyperglycaemia in all animals. However, 2months later, hyperglycaemia was significantly less pronounced in the rats fed a C. colocynthis oil-enriched diet compared with other rat groups (7.9mM versus 12mM and 16mM with colocynth versus olive and sunflower oils, respectively). Assessment of insulin sensitivity using the homoeostasis model assessment (HOMA... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2248537 Tue, 03 Mar 2009 05:00:00 +0100 2248537 http://www.medworm.com/index.php?rid=2231215&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19251447%26dopt%3DAbstract CONCLUSION: Consistent negative associations between carbohydrate intake and BMI and WC were seen in this random representative sample of the general male population. The associations between fat intake and these measures of being overweight were attenuated on adjusting for carbohydrate intake. Thus, the balance of carbohydrate-to-fat intake is an important element in obesity in a general male population, and should be highlighted in dietary guidelines. PMID: 19251447 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2231215 Fri, 27 Feb 2009 05:00:00 +0100 2231215 http://www.medworm.com/index.php?rid=2231214&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19251448%26dopt%3DAbstract CONCLUSION: Experienced, well-controlled, complication-free young diabetic patients can safely go scuba diving, provided that they apply a rigorous protocol based on serial pre-dive BG measurements. The specific variables of underwater diving do not appear to involve significant additional risks of hypoglycaemia. PMID: 19251448 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2231214 Fri, 27 Feb 2009 05:00:00 +0100 2231214 http://www.medworm.com/index.php?rid=2231213&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19251449%26dopt%3DAbstract Authors: Karaca M, Magnan C, Kargar C In the adult, the pancreatic beta-cell mass adapts insulin secretion to meet long-term changes in insulin demand and, in particular, in the presence of insulinresistance that is either physiological, such as pregnancy, or pathophysiological, such as obesity. The failure of beta cells to compensate for insulinresistance is a major component of impaired glucose homeostasis and overt diabetes. This defect is clearly the consequence of a decline of insulin response to glucose due to functional beta-cell deficiency. It is also the consequence of an inability of the endocrine pancreas to adapt the beta-cell mass to insulin demand (pancreas plasticity), which eventually leads to a decrease in functional beta-cell mass. This idea has resulted in considerab... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2231213 Fri, 27 Feb 2009 05:00:00 +0100 2231213 http://www.medworm.com/index.php?rid=2231216&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19250850%26dopt%3DAbstract CONCLUSION: Knowledge of diabetes in a T2D population with a high prevalence of illiteracy was poor. Limited family income and lack of self-care are other predictors of knowledge deficits. Efforts need to be focused on educational programmes with strategies to assist T2D patients of limited education and income to manage their disease more effectively. PMID: 19250850 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2231216 Thu, 26 Feb 2009 05:00:00 +0100 2231216 http://www.medworm.com/index.php?rid=2231217&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19249234%26dopt%3DAbstract Authors: Collet-Gaudillat C, Billon-Bancel A, Beressi JP A 54-year-old woman was referred to hospital because of poor metabolic control. Clinical examination revealed marked acanthosis nigricans, and a striking lack of adipose tissue on the limbs, and excess fat deposits on the neck and face. She had been treated for diabetes since 2001 with high doses of insulin along with metformin. Clinical tests showed hypertriglyceridaemia with low high density lipoprotein (HDL) cholesterol, and cholestasis with mild cytolysis. Dunnigan syndrome (familial partial lipodystrophy type 2) was suspected and confirmed by molecular genetics. Pioglitazone was added to her treatment, and follow-up showed improvement of metabolic control 7 months after introducing pioglitazone, and improvement of insulin se... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2231217 Wed, 25 Feb 2009 05:00:00 +0100 2231217 http://www.medworm.com/index.php?rid=2221172&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19246227%26dopt%3DAbstract CONCLUSION: Among normal-weight men, those who developed the metabolic syndrome in adulthood had smaller gains in BMI during infancy and were thinner at age 7 years. These results support findings that early growth may play an important role in the development of the metabolic syndrome. PMID: 19246227 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2221172 Tue, 24 Feb 2009 05:00:00 +0100 2221172 http://www.medworm.com/index.php?rid=2221171&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19246228%26dopt%3DAbstract CONCLUSION: Among obese individuals, those who develop the metabolic syndrome were lighter and thinner from the age of two to 11 years compared with those who did not. These findings support the importance of early childhood growth in determining the metabolic consequences of obesity. PMID: 19246228 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2221171 Tue, 24 Feb 2009 05:00:00 +0100 2221171 http://www.medworm.com/index.php?rid=2215351&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19237305%26dopt%3DAbstract CONCLUSION: In very old patients, low BMI, low DBP, low total and HDL cholesterol, and high insulin sensitivity predict total mortality, indicating a "reverse metabolic syndrome" that is probably attributable to malnutrition and/or chronic disorders. These inverse associations limit the relevance of conventional risk factors. Previous CV events and HDL cholesterol remain strong predictors of mortality. Future studies should determine if and when the prevention and treatment of malnutrition in the elderly should be incorporated into conventional CV prevention. PMID: 19237305 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2215351 Sat, 21 Feb 2009 05:00:00 +0100 2215351 http://www.medworm.com/index.php?rid=2209080&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230737%26dopt%3DAbstract CONCLUSIONS: Betaglucan enriched bread may contribute to the improvement of the lipid profile and insulin resistance in patients with T2D. PMID: 19230737 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2209080 Thu, 19 Feb 2009 05:00:00 +0100 2209080 http://www.medworm.com/index.php?rid=2209081&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230736%26dopt%3DAbstract Authors: Vija L, Farge D, Gautier JF, Vexiau P, Dumitrache C, Bourgarit A, Verrecchia F, Larghero J Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic progenitor cells that are being explored as a promising new treatment for tissue regeneration. Although their immunomodulatory properties are not yet completely understood, their low immunogenic potential together with their effects on immune response make them a promising therapeutic tool for severe refractory autoimmune diseases. Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic beta cells. While insulin replacement represents the current therapy for type 1 diabetes, its metabolic control remains difficult, as exogenous insulin cannot exactly mimic the physiology of insulin secretion... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2209081 Wed, 18 Feb 2009 05:00:00 +0100 2209081 http://www.medworm.com/index.php?rid=2086360&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19124261%26dopt%3DAbstract Authors: Jung C, Shemyakin A, Böhm F, Pernow J PMID: 19124261 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2086360 Sat, 03 Jan 2009 05:00:00 +0100 2086360 http://www.medworm.com/index.php?rid=2059406&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19097818%26dopt%3DAbstract CONCLUSION: Screening improved the quality of the ocular follow-up in diabetics in this rural area. However, improvements in management are needed to lower the cost of such a programme. PMID: 19097818 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2059406 Fri, 19 Dec 2008 05:00:00 +0100 2059406 http://www.medworm.com/index.php?rid=2045341&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18951876%26dopt%3DAbstract In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 (PDX-1) in the ALK7 pathway. A conserved Smad binding element was related to the promoter activation. Phosphorylated Smad2/Smad3 and PDX-1 were bound to insulin gene with Nodal and Activin AB, and the phosphorylated Smad2/Smad3 interacted with PDX-1. These results indicate that one of the direct target genes of Nodal and Activin AB signals is the insulin gene in pancreatic beta-cells and that PDX-1 is directly involved in the ALK7-Smad pathway. PMID: 18951876 [PubMed - indexed for MEDLINE] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2045341 Thu, 18 Dec 2008 07:02:19 +0100 2045341 http://www.medworm.com/index.php?rid=2025707&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19062325%26dopt%3DAbstract CONCLUSION: The results of this exploratory study show that the polymorphism Arg585Gln in SREBF-1 is not associated with the KPD phenotype. Further studies in larger populations are needed to confirm our findings. PMID: 19062325 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2025707 Wed, 03 Dec 2008 05:00:00 +0100 2025707 http://www.medworm.com/index.php?rid=2010337&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19046913%26dopt%3DAbstract CONCLUSION: The prevalence of treated and untreated type 2 diabetes mellitus in France was 4.57%. PMID: 19046913 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2010337 Thu, 27 Nov 2008 05:00:00 +0100 2010337 http://www.medworm.com/index.php?rid=2010336&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19046914%26dopt%3DAbstract Authors: Slama L, Le Camus C, Serfaty L, Pialoux G, Capeau J, Gharakhanian S The importance of metabolic disorders in the pathophysiology of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections is becoming increasingly apparent. Metabolic anomalies, with their potential for multiple-organ involvement, are to be expected, given the chronic nature of these diseases, and the intracellular dysregulation associated with them. Not only have the endocrine and cytokine metabolic anomalies seen in HIV and HCV infections been linked with the metabolic syndrome, but they also appear to have some pathways in common. Studying the differences and similarities between these metabolic anomalies may add to our understanding of HIV and HCV infection, and provide guidance on how to t... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2010336 Thu, 27 Nov 2008 05:00:00 +0100 2010336 http://www.medworm.com/index.php?rid=2010335&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19046915%26dopt%3DAbstract CONCLUSION: Although there was no evidence of an association between the ENPP1 K121Q variant and the general phenotype of T2D, we did find an association with adult obesity and T2D. The Q121 allele frequency in Morocco is 37.3%, placing it between European Caucasians (15%) and Black Africans (79%). This study is the first to report an association between K121Q and metabolic diseases in the Moroccan population. PMID: 19046915 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2010335 Thu, 27 Nov 2008 05:00:00 +0100 2010335 http://www.medworm.com/index.php?rid=2010334&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19046916%26dopt%3DAbstract CONCLUSION: A positive relationship was found between MetS and depression, but not between MetS and anxiety, in male Japanese workers. The specific factors comprising MetS, such as waist circumference, may be a reflection of the depression. PMID: 19046916 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2010334 Thu, 27 Nov 2008 05:00:00 +0100 2010334 http://www.medworm.com/index.php?rid=2010333&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19046917%26dopt%3DAbstract This article proposes a strategy for the diagnosis and treatment of neuropathic pain due to diabetic peripheral sensory neuropathy, based on 15 years of experience in French pain-management centres and on the available literature. In the diabetic patient with chronic pain in the lower limbs, the first step in the diagnostic process is to identify the neuropathic origin of the pain. The second step is to evaluate the patient's medical history and make a rigorous baseline assessment of the neuropathic pain symptoms to determine an effective pain-management strategy. In the third step, adequate and well-tolerated treatment directed towards a variety of painful symptoms is selected, taking into account other co-morbidities such as anxiety and depression. This report reports on the clinical asp... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=2010333 Thu, 27 Nov 2008 05:00:00 +0100 2010333 http://www.medworm.com/index.php?rid=1998409&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19038564%26dopt%3DAbstract CONCLUSION: This study showed that nearly 75% of nondiabetic patients experience a moderate, but significant, increase in either fasting or postprandial BG levels in the first two days following major arthroplasty. PMID: 19038564 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1998409 Tue, 25 Nov 2008 05:00:00 +0100 1998409 http://www.medworm.com/index.php?rid=1995403&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19036624%26dopt%3DAbstract Authors: Girard J This paper briefly reviews the concept of incretins and describes the biological effects of the two incretins identified so far: the glucose-dependent insulinotropic polypeptide (GIP); and the glucagon-like peptide-1 (GLP-1). GIP is released by the Kcells of the duodenum, while GLP-1 is released by the Lcells of the distal ileum, in response to nutrient absorption. GIP and GLP-1 stimulate insulin biosynthesis and insulin secretion in a glucose-dependent manner. In addition, they increase beta-cell mass. GIP has a specific effect on adipose tissue to facilitate the efficient disposal of absorbed fat and, thus, may be involved in the development of obesity. GLP-1 has specific effects on pancreatic alpha cells, the hypothalamus, and gastrointestinal and cardiovascular sy... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1995403 Mon, 24 Nov 2008 05:00:00 +0100 1995403 http://www.medworm.com/index.php?rid=1989271&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19027337%26dopt%3DAbstract In this report, we discuss the association between non-ketotic hyperglycaemia and ballism along with a review of the literature. PMID: 19027337 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1989271 Thu, 20 Nov 2008 05:00:00 +0100 1989271 http://www.medworm.com/index.php?rid=1989272&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026584%26dopt%3DAbstract Authors: , Burcelin R The first antidiabetic agent was a hormone-insulin-and ever since, all therapeutic strategies have been based on the synthesis of chemical compounds to bind its receptors or transcription factors, or to trigger its intracellular mechanisms. Eighty years on, new therapeutic molecules are available for the treatment of diabetes and, again, are based on a hormone-glucagon-like peptide-1 (GLP-1). Whereas the theoretical benefit of insulin is based on normalization of functional physiology, therapeutic strategies based on GLP-1 aim to increase the circulating concentration of a natural component-the hormone GLP-1. There are two strategies for increasing GLP-1 plasma concentrations: replace the hormone with a long-acting analogue or molecule with a longer half-life; an... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1989272 Wed, 19 Nov 2008 05:00:00 +0100 1989272 http://www.medworm.com/index.php?rid=1979316&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19019716%26dopt%3DAbstract Authors: Wautier JL, Grossin N PMID: 19019716 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1979316 Mon, 17 Nov 2008 05:00:00 +0100 1979316 http://www.medworm.com/index.php?rid=1979315&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19019717%26dopt%3DAbstract CONCLUSION: In primary care, a lack of control of triglycerides, HbA(1c) and, to a lesser extent, blood pressure increases with waist circumference independently of confounders. This suggests that abdominal obesity is associated of poor results in the treatment of diabetes and hypertriglyceridaemia. PMID: 19019717 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1979315 Mon, 17 Nov 2008 05:00:00 +0100 1979315 http://www.medworm.com/index.php?rid=1917472&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18955007%26dopt%3DAbstract CONCLUSION: The mtDNA A3243G mutation associated with the gastrointestinal manifestations observed in the affected family should be regarded as a possible cause of CIPO and unexplained recurrent pancreatitis. However, the mutation is probably only weakly involved in cases of isolated recurrent pancreatitis. PMID: 18955007 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1917472 Sat, 25 Oct 2008 04:00:00 +0100 1917472 http://www.medworm.com/index.php?rid=1913969&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18952477%26dopt%3DAbstract CONCLUSION: These results indicate a doubling of the incidence of type 1 diabetes in children every 30 years in Aquitaine, with an even steeper increase among younger children, thus underscoring the need for appropriate adaptation of the system of healthcare provision. PMID: 18952477 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1913969 Fri, 24 Oct 2008 04:00:00 +0100 1913969 http://www.medworm.com/index.php?rid=1907430&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18948050%26dopt%3DAbstract CONCLUSION: The present meta-analysis represents the best information available to date that addresses this issue, and suggests that periodontal treatment could improve glycaemic control. Nevertheless, these results need to be viewed with caution because of a lack of robustness, and deficiencies in the design of some of the studies included. A randomized controlled trial with sufficient statistical power would help to confirm the results of this meta-analysis. PMID: 18948050 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1907430 Tue, 21 Oct 2008 04:00:00 +0100 1907430 http://www.medworm.com/index.php?rid=1904997&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18945633%26dopt%3DAbstract CONCLUSION: Complications and/or associated diseases were more frequent in this cohort of elderly diabetic patients compared with those in studies not based on clinical examinations. Our results highlight the inadequate management, given the frequent discrepancy between day-to-day HbA(1c) and HbA(1c) targets, of such patients. PMID: 18945633 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1904997 Mon, 20 Oct 2008 04:00:00 +0100 1904997 http://www.medworm.com/index.php?rid=1887813&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18926757%26dopt%3DAbstract CONCLUSION: Our study supports a relationship between serum AGE and nephropathy in diabetes, and suggests that orally administered microencapsulated LZ can exert kidney-protective activity in a diabetic animal model. PMID: 18926757 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1887813 Tue, 14 Oct 2008 04:00:00 +0100 1887813 http://www.medworm.com/index.php?rid=1887812&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18926758%26dopt%3DAbstract CONCLUSION: These findings suggest that nighttime systolic BP per se appeared to be a stronger predictor of an excess risk of CV events compared with reverse-dipping status. PMID: 18926758 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1887812 Tue, 14 Oct 2008 04:00:00 +0100 1887812 http://www.medworm.com/index.php?rid=1885600&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18922724%26dopt%3DAbstract CONCLUSION: Unlike in type 1 diabetes, HbA(1c) did not correlate with mean plasma glucose in CFRD subjects. Thus, having a normal HbA(1c) may not be sufficient to indicate a low risk of diabetes complications in CFRD. Further studies are required to explain such a discrepancy. PMID: 18922724 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1885600 Mon, 13 Oct 2008 04:00:00 +0100 1885600 http://www.medworm.com/index.php?rid=1885599&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18922725%26dopt%3DAbstract CONCLUSION: A lipid-parameter-based index using fasting samples provides a simple means of screening for insulin resistance in the healthy population. PMID: 18922725 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1885599 Mon, 13 Oct 2008 04:00:00 +0100 1885599 http://www.medworm.com/index.php?rid=1885598&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18922726%26dopt%3DAbstract CONCLUSION: AEB is present in French diabetic patients at levels that are probably higher than among the general population. These results highlight the need for: (1) greater awareness among diabetes clinicians of the problem; (2) regular screening of diabetic patients for AEB; and (3) adaptation of therapeutic and dietary recommendations for this patient subgroup. PMID: 18922726 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1885598 Mon, 13 Oct 2008 04:00:00 +0100 1885598 http://www.medworm.com/index.php?rid=1850249&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18829362%26dopt%3DAbstract CONCLUSION: QOL assessed by DQOL improved after therapeutic education and during the following year. The improvement in DQOL score at three months correlated with a reduction in HbA(1c) levels and appeared to particularly benefit to those who had severe hypoglycaemia before the programme. PMID: 18829362 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1850249 Mon, 29 Sep 2008 04:00:00 +0100 1850249 http://www.medworm.com/index.php?rid=1850248&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18829363%26dopt%3DAbstract CONCLUSION: These are the first cases of fulminant type 1 diabetes reported in Caucasians. These cases reveal new perspectives as regards the worldwide distribution of this intriguing clinical entity. PMID: 18829363 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1850248 Mon, 29 Sep 2008 04:00:00 +0100 1850248 http://www.medworm.com/index.php?rid=1850247&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18829364%26dopt%3DAbstract Authors: Tiengo A, Fadini GP, Avogaro A Sleep-disordered breathing and sleep apnoea are conditions frequently associated with comorbidity, including obesity, diabetes, hypertension, insulin resistance (metabolic syndrome) and cardiovascular disease. The diabetic state (type 1 and type 2 diabetes) may be associated to diminished lung function and, in particular, decreased vital capacity, and the association between chronic obstructive pulmonary disease (COPD) and type 2 diabetes may be due to a shared inflammatory process. Also, the alteration in circulating endothelial progenitor cells found in respiratory disease, the metabolic syndrome and cardiovascular disease reflect a common condition of endothelial dysfunction. PMID: 18829364 [PubMed - as supplied by publisher] (Source: Diab... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1850247 Mon, 29 Sep 2008 04:00:00 +0100 1850247 http://www.medworm.com/index.php?rid=1843743&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18824382%26dopt%3DAbstract CONCLUSIONS: We conclude that variability of blood glucose may be important in the development of peripheral neuropathy in patients with type 1 diabetes, and that the nervous system may be particularly vulnerable to glycaemic variability. PMID: 18824382 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1843743 Fri, 26 Sep 2008 04:00:00 +0100 1843743 http://www.medworm.com/index.php?rid=1843744&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18823806%26dopt%3DAbstract CONCLUSION: This study shows that, in fit healthy subjects, the analytical device, reference used to build the protocol and ventilation responses affect metabolic indices. In this population, and particularly to obtain interpretable metabolic indices, we recommend a protocol based on the true MAP or one adapted to include the transition from fat to carbohydrate. The correlation between metabolic indices and lactate/ventilation thresholds suggests that shorter, classical maximum progressive exercise testing may be an alternative means of estimating these indices in relatively fit subjects. However, this needs to be confirmed in patients who have metabolic defects. PMID: 18823806 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1843744 Thu, 25 Sep 2008 04:00:00 +0100 1843744 http://www.medworm.com/index.php?rid=1788094&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18783976%26dopt%3DAbstract CONCLUSION: The maternal perception of family cohesiveness and maternal alexithymia predict on glycaemic control in children and adolescents with diabetes. PMID: 18783976 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1788094 Mon, 08 Sep 2008 04:00:00 +0100 1788094 http://www.medworm.com/index.php?rid=1716671&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18706843%26dopt%3DAbstract Authors: Reach G The efficient implementation of healthcare is often jeopardized by the lack of patient adherence to medical recommendations and by inadequate healthcare-provider adherence to current guidelines, a phenomenon recently described as "clinical inertia". We propose here a theoretical model, based on concepts developed in the field of analytical philosophy of mind, that describes the mental mechanisms shared by the two phenomena, thus explaining their synergistically deleterious influence on the efficiency of care. We suggest that a failure to give preference to the long-term benefits of treatment intensification may represent a common mechanism underlying both patient non-adherence and physician clinical inertia. We dub such a failure as "clinical myopia". The model is expl... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1716671 Wed, 13 Aug 2008 04:00:00 +0100 1716671 http://www.medworm.com/index.php?rid=1707911&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18703370%26dopt%3DAbstract CONCLUSION: The recommended creatinine-based estimations of GFR need to be improved. CysC assay helps in the diagnosis and stratification of CKD and leads to better estimates of GFR in diabetic patients without any substantial increase in complexity. PMID: 18703370 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1707911 Tue, 12 Aug 2008 04:00:00 +0100 1707911 http://www.medworm.com/index.php?rid=1707912&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18701333%26dopt%3DAbstract CONCLUSION: The association of low sRAGE with high CML-protein levels in diabetic patients who developed severe diabetic complications supports the hypothesis that sRAGE protects vessels against AGE-mediated diabetic microvascular damage. PMID: 18701333 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1707912 Mon, 11 Aug 2008 04:00:00 +0100 1707912 http://www.medworm.com/index.php?rid=1699758&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18693056%26dopt%3DAbstract Authors: Oriot P, Feys JL, Mertens de Wilmars S, Misson A, Ayache L, Fagnart O, Gruson D, Luts A, Jamart J, Hermans MP, Buysschaert M Atypical antipsychotic drugs (AADs) induce weight gain and truncal adiposity, and even the metabolic syndrome (MetS), which may progress to IFG/IGT or DM. AAD effects in lean schizophrenic patients without MetS have not been documented, especially in terms of weight gain and changes in insulin sensitivity (S), beta-cell function (beta) and adiponectinaemia. We prospectively determined the effects of nine-month therapy with AADs on anthropometrics, metabolism and adiponectinaemia, including homoeostasis model assessment (HOMA) modelling of S, beta and betaxS (hyperbolic product, assessing individual beta adjusted for S). We analyzed 36 schizophrenic subje... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1699758 Fri, 08 Aug 2008 04:00:00 +0100 1699758 http://www.medworm.com/index.php?rid=1699759&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18692423%26dopt%3DAbstract CONCLUSION: A vascular risk evaluation in diabetic patients could include ultrasound imaging assessment for cervical artery atheroma and our data suggest that such an evaluation could be focused solely on the carotid arteries. PMID: 18692423 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1699759 Thu, 07 Aug 2008 04:00:00 +0100 1699759 http://www.medworm.com/index.php?rid=1691330&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18684654%26dopt%3DAbstract CONCLUSION: The findings of this study suggest a favourable relationship between adiponectin and both metabolic profile and subsequent changes in TG level in young adolescents. PMID: 18684654 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1691330 Mon, 04 Aug 2008 04:00:00 +0100 1691330 http://www.medworm.com/index.php?rid=1681955&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675299%26dopt%3DAbstract Authors: Lundy RF Among well-nourished populations, eating beyond homeostatic needs when presented with caloric-dense palatable food evidences the assertion that an increasing proportion of consumption is driven by pleasure, not just by the need for calories. This presents a major health crisis because the affective component of foods constitutes a behavioral risk factor that promotes over consumption [Sorensen, L.B., Moller, P., Flint, A., Martens, M., Raben, A., 2003. Effect of sensory perception of foods on appetite and food intake: a review of studies on humans. Int. J. Obes. Relat. Metab. Disord. 27, 1152-1166; Yeomans, M.R., Blundell, J.E., Leshem, M., 2004. Palatability: response to nutritional need or need-free stimulation of appetite? Br. J. Nutr. 92 (Suppl. 1), S3-S14]. Overw... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1681955 Tue, 15 Jul 2008 04:00:00 +0100 1681955 http://www.medworm.com/index.php?rid=1638848&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18635386%26dopt%3DAbstract CONCLUSION: Patient education in primary care is still mostly an illusion, with many gaps that hinder education for both patients and professionals. The training of health professionals needs to meet the challenge of chronic diseases by integrating aspects from the fields of education and the social sciences. PMID: 18635386 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1638848 Tue, 15 Jul 2008 04:00:00 +0100 1638848 http://www.medworm.com/index.php?rid=1637100&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18632297%26dopt%3DAbstract CONCLUSION: MDRO are pathogens frequently isolated from diabetic foot infection in our foot clinic. Nevertheless, their presence appears to have no significant impact on healing time if early aggressive treatment, as in the present study, is given, including empirical broad-spectrum antibiotic treatment, later adjusted according to microbiological findings. PMID: 18632297 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1637100 Mon, 14 Jul 2008 04:00:00 +0100 1637100 http://www.medworm.com/index.php?rid=1581609&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18599336%26dopt%3DAbstract CONCLUSION: BNP can be used to pre-screen asymptomatic type 2 diabetic patients with LV dysfunction, and may reveal vascular remodelling in type 2 diabetes mellitus. PMID: 18599336 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1581609 Tue, 01 Jul 2008 04:00:00 +0100 1581609 http://www.medworm.com/index.php?rid=1559660&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18586543%26dopt%3DAbstract Authors: Ambonville C, Meas T, Lecleire-Collet A, Laloi-Michelin M, Virally M, Kevorkian JP, Paques M, Massin P, Guillausseau PJ A case of maternally inherited diabetes and deafness (MIDD)-associated macular pattern dystrophy with a 15-year follow-up is reported. On initial examination at age 37, visual acuity was normal, but chorioretinal atrophy at the posterior pole was already present in both eyes. At age 52, visual acuity remained normal in the right eye and was only slightly decreased in the left eye despite notable extension of the areas of chorioretinal atrophy in that eye. No evidence of diabetic retinopathy was present at any time. This case shows that visual acuity can remain stable in the long term despite extensive lesions of macular pattern dystrophy. PMID: 18586543 [... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1559660 Fri, 27 Jun 2008 04:00:00 +0100 1559660 http://www.medworm.com/index.php?rid=1559661&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18585071%26dopt%3DAbstract CONCLUSION: Genuine magnetic field exposure has no advantage over sham exposure in reducing pain intensity, improving quality of life, and decreasing sleep disturbances and HbA(1c). PMID: 18585071 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1559661 Wed, 25 Jun 2008 04:00:00 +0100 1559661 http://www.medworm.com/index.php?rid=1550482&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18583169%26dopt%3DAbstract CONCLUSION: Auto-immune cerebellar ataxia related to GAD-Ab is a rare condition that typically affects women with late-onset type 1 diabetes or other auto-immune disorders, including auto-immune polyendocrinopathy. Immunomodulatory treatment may be effective. PMID: 18583169 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1550482 Tue, 24 Jun 2008 04:00:00 +0100 1550482 http://www.medworm.com/index.php?rid=1525014&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18556231%26dopt%3DAbstract CONCLUSION: Aggressive sequential multimodal therapy can prolong the survival of patients with SMI even in the presence of liver metastases. PMID: 18556231 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1525014 Fri, 13 Jun 2008 04:00:00 +0100 1525014 http://www.medworm.com/index.php?rid=1517887&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18550411%26dopt%3DAbstract Authors: Lafontan M, Girard J Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low high-density lipoprotein cholesterol that contribute to the later appearance of type 2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver, and interact with hepatocytes and various immune cells in the liver. The functional characteristics of visceral adipose tissue will be compared with subcutaneous adipose tissue to clarify the major mechanisms affecting free fatty acid metabolism and cytokine production. PMID: 18550411 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1517887 Tue, 10 Jun 2008 04:00:00 +0100 1517887 http://www.medworm.com/index.php?rid=1506916&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18539497%26dopt%3DAbstract CONCLUSIONS: Immigrants from the Middle East showed a four-fold higher risk of diabetes compared with Swedish-born subjects in two of the three data sources. More studies are needed to confirm these results, but the findings call for targeted preventative strategies in this population group. PMID: 18539497 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1506916 Fri, 06 Jun 2008 04:00:00 +0100 1506916 http://www.medworm.com/index.php?rid=1496398&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18524662%26dopt%3DAbstract CONCLUSION: The number of treated diabetic patients greatly increased between 2000 and 2005. At the same time, their associated cardiovascular risk factors were more frequently managed by drug therapy. As a result, the total expenditures for the healthcare system for treating diabetes and its associated cardiovascular risk factors doubled in five years, amounting to 1.8 billion euros in 2005. PMID: 18524662 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1496398 Mon, 02 Jun 2008 04:00:00 +0100 1496398 http://www.medworm.com/index.php?rid=1479756&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18511324%26dopt%3DAbstract Authors: Monnier L, Colette C, Owens DR From a pathophysiological point of view, type 2 diabetes is a well-characterised disease, since the glycaemic disorders result from three main mechanisms (the De Fronzo's triumvirate): a defect of beta-cell function, decreased disposal of glucose in peripheral tissues and overproduction of glucose by the liver. Each defect is subject to 24-h circadian variations and to inevitable worsening with time. As a consequence, therapeutic strategies should reflect whether patients retain sufficient insulin secretion or suffer from a more severe secretory defect that progresses from being responsive to oral diabetic agents to the insulin-requiring stage. Identifying the different pathophysiological stages is a prerequisite for successful therapeutic strate... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1479756 Tue, 27 May 2008 04:00:00 +0100 1479756 http://www.medworm.com/index.php?rid=1453685&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18487065%26dopt%3DAbstract CONCLUSION: In this study involving the Tunisian population, we identified genetic variants within CAPN10 that are linked with T2DM and a novel haplotype combination, 121/221, associated with an increased susceptibility to T2DM. PMID: 18487065 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1453685 Fri, 16 May 2008 04:00:00 +0100 1453685 http://www.medworm.com/index.php?rid=1453686&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18486512%26dopt%3DAbstract CONCLUSION: Present study provided supporting evidence from a cohort of Asian subjects about the ALT and future type 2 diabetes risk. PMID: 18486512 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1453686 Thu, 15 May 2008 04:00:00 +0100 1453686 http://www.medworm.com/index.php?rid=1438865&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18468931%26dopt%3DAbstract Authors: Porta M PMID: 18468931 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1438865 Fri, 09 May 2008 04:00:00 +0100 1438865 http://www.medworm.com/index.php?rid=1438864&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18468932%26dopt%3DAbstract Authors: Berlin I Smoking is the leading avoidable cause of cardiovascular mortality worldwide. The aim of this report is to briefly review the existing evidence regarding smoking and cardiovascular risk, and to analyze in greater detail the links between tobacco use and metabolic disorders. The evidence so far shows that smoking dose-dependently increases the risk of impaired glucose tolerance, the incidence of type 2 diabetes mellitus and abdominal-type obesity. Although smokers have a lower body mass index than do nonsmokers, recent data show that they have higher waist-to-hip ratios and waist circumferences, established risk factors for cardiovascular disorders-in particular, for coronary heart disease. We propose that smoking may lead not only directly, but also indirectly via the... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1438864 Fri, 09 May 2008 04:00:00 +0100 1438864 http://www.medworm.com/index.php?rid=1438863&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18468933%26dopt%3DAbstract CONCLUSION: Endurance training at V(T) level prevented the decline in aerobic working capacity seen in untrained diabetics over the study period, and resulted in a marked reduction in healthcare costs due to less treatments and fewer hospitalizations. PMID: 18468933 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1438863 Fri, 09 May 2008 04:00:00 +0100 1438863 http://www.medworm.com/index.php?rid=1438862&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18468934%26dopt%3DAbstract CONCLUSION: By modifying the mathematical expression of HOMA, we were able to achieve comparable CVs for QUICKI and HOMA. However, the CV should be used to assess the reproducibility of techniques to measure glucose and insulin, not of mathematical formulas. When evaluating indices for the assessment of insulin sensitivity, the key point is how well they correlate with the 'gold-standard' glucose clamp. PMID: 18468934 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1438862 Fri, 09 May 2008 04:00:00 +0100 1438862 http://www.medworm.com/index.php?rid=1438866&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18468470%26dopt%3DAbstract CONCLUSION: Fundus photography combined with telemedicine has the potential to improve the regular annual evaluation for diabetic retinopathy. The organization of the network around a central reading centre serves to guarantee quality control. PMID: 18468470 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1438866 Wed, 07 May 2008 04:00:00 +0100 1438866 http://www.medworm.com/index.php?rid=1415922&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18448376%26dopt%3DAbstract CONCLUSION: A single bout of exercise at moderate intensity in type 2 diabetics did not improve S(G), but markedly improved the low S(I) values found in these patients, indicating that the acute effects of exercise on S(I) are quantitatively important in the interpretation of training-related S(I) changes and may even be therapeutically useful on their own. Surrogates such as homoeostasis model assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) were not sensitive enough to detect this increase in S(I) and should probably be used with caution in the follow-up of exercise protocols in diabetic patients. PMID: 18448376 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1415922 Mon, 28 Apr 2008 04:00:00 +0100 1415922 http://www.medworm.com/index.php?rid=1401132&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18436464%26dopt%3DAbstract CONCLUSION: Belonging to a patients' organization was associated with better HbA(1c) in T1DM. In T2DM, which progresses relentlessly, similar HbA(1c) levels and better lipid profiles were observed, despite longer known disease durations and lower beta-cell function. These were not explained by gender, clinical, renal, therapeutic or educational parameters, but might reflect more responsibility, empowerment and/or compliance in terms of the condition or its management. PMID: 18436464 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1401132 Tue, 22 Apr 2008 04:00:00 +0100 1401132 http://www.medworm.com/index.php?rid=1390555&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18424210%26dopt%3DAbstract CONCLUSION: QA for DR telescreening should be a continuous process to provide performance feedback, thus guaranteeing a high standard for delivered results. Almost all of the predetermined QA standards in OPHDIAT((c)) for screening and grading were met. Besides the quality/sensitivity of the screening/grading modalities, it is important to evaluate at-risk patients so that they can be treated efficiently; this should be addressed in a global QA programme. PMID: 18424210 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1390555 Wed, 16 Apr 2008 04:00:00 +0100 1390555 http://www.medworm.com/index.php?rid=1373020&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18406188%26dopt%3DAbstract CONCLUSION: The three-field strategy without pupil dilation represents a good compromise, with reasonable sensitivity and good comfort (short examination duration, able to drive after photography) favouring patient compliance with the screening programme. PMID: 18406188 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1373020 Wed, 09 Apr 2008 04:00:00 +0100 1373020 http://www.medworm.com/index.php?rid=1373019&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18406189%26dopt%3DAbstract CONCLUSION: Psychosocial deprivation is an independent determinant of MetS in non-obese people, and elderly psychosocially deprived women, even if not obese, are at a particularly high risk of MetS. Educational efforts need to be developed to prevent MetS and its consequences in this population. PMID: 18406189 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1373019 Wed, 09 Apr 2008 04:00:00 +0100 1373019 http://www.medworm.com/index.php?rid=1359952&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396086%26dopt%3DAbstract CONCLUSION: Our study demonstrates that it is possible to organize educational sessions for diabetic patients in a private-practice setting. At six months, patients receiving these sessions showed benefits in terms of blood glucose control and other important markers of self-management of their disease. PMID: 18396086 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1359952 Fri, 04 Apr 2008 04:00:00 +0100 1359952 http://www.medworm.com/index.php?rid=1359951&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396087%26dopt%3DAbstract CONCLUSIONS: CCR use by the elderly with type 2 diabetes in the year following antidiabetic initiation is low, and prior use of individual cardioprotective drugs is a strong predictor of its use. These findings suggest that the treatment of important modifiable risk factors for cardiovascular disease is suboptimal. PMID: 18396087 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1359951 Fri, 04 Apr 2008 04:00:00 +0100 1359951 http://www.medworm.com/index.php?rid=1359950&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396088%26dopt%3DAbstract CONCLUSION: This study shows that a moderate training protocol targeted at the LIPOX(max) in T2D patients improves their ability to oxidize lipids during exercise, and that this improvement is associated with enhanced muscle oxidative capacity. PMID: 18396088 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1359950 Fri, 04 Apr 2008 04:00:00 +0100 1359950 http://www.medworm.com/index.php?rid=1318814&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18353699%26dopt%3DAbstract Authors: Carpentier AC Insulin resistance (IR) and impaired glucose-stimulated insulin secretion (GSIS) are the two primary pathophysiological abnormalities leading to the development of type 2 diabetes (T2D). Over the past two decades, a large body of work has implicated enhanced delivery of fatty acids to non-adipose tissues in the development of both IR and impaired GSIS. As the net whole-body import of fatty acids occurs in the postprandial state, tissue fatty acid overexposure has been linked to this physiological state. Although many advances have been made in our understanding of these lipotoxic effects at the cellular level, the precise mechanisms of lipotoxicity at the whole-body level in humans during the development of T2D is still a subject of debate. Important advances con... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1318814 Mon, 17 Mar 2008 04:00:00 +0100 1318814 http://www.medworm.com/index.php?rid=1318813&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18353700%26dopt%3DAbstract Authors: Jaquet A, Deloumeaux J, Dumoulin M, Bangou J, Donnet JP, Foucan L OBJECTIVE: To evaluate the metabolic syndrome (MS) and Framingham risk score (FRS) as predictors of cardiovascular (CV) events in Caribbean Indian patients who have type 2 diabetes (T2D) or impaired glucose tolerance (IGT). METHOD: A longitudinal and retrospective study was conducted involving patients classified as T2D or IGT in a first study in 1997 who responded for a second examination in 2006. Nonparametric tests and Cox's proportional hazards model were used. Hazard ratios (HRs) and their confidence intervals (95% CI) for risk of a first CV event, according to the presence of MS or a high FRS, were estimated. For MS, the models were adjusted for age, gender and smoking status. RESULTS: A total of 148 patie... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1318813 Mon, 17 Mar 2008 04:00:00 +0100 1318813 http://www.medworm.com/index.php?rid=1310665&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18343703%26dopt%3DAbstract CONCLUSION: In France, as per the official recommendations, almost all people on insulin treatment use a SMBG device while, overall, their glucose control remains poor. More than one-third of those with oT2D regularly perform SMBG. In only 3% of people, the regular use of SMBG does not appear to be related to any special needs or events (such as insulin treatment, occurrence of severe hypoglycaemia or chronic complications). PMID: 18343703 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1310665 Fri, 14 Mar 2008 04:00:00 +0100 1310665 http://www.medworm.com/index.php?rid=1293792&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18329309%26dopt%3DAbstract CONCLUSION: Plasma 15-F(2t) isoPs are increased during acute fructose loading in T2DM. Knowing the potentially deleterious effect of plasma 15-F(2t) isoPs-in particular, vascular lesions-and in light of our results, it is necessary to reconsider fructose consumption in T2DM patients, as we can now show, for the first time, a possible association between acute fructose loading and deleterious effects in such patients. PMID: 18329309 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1293792 Thu, 06 Mar 2008 05:00:00 +0100 1293792 http://www.medworm.com/index.php?rid=1293791&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18329310%26dopt%3DAbstract Authors: Karelis AD, Rabasa-Lhoret R PMID: 18329310 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1293791 Thu, 06 Mar 2008 05:00:00 +0100 1293791 http://www.medworm.com/index.php?rid=1293790&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18329311%26dopt%3DAbstract Authors: Carreira E, Lepercq J, Bouché C, Dubois-Laforgue D, Timsit J PMID: 18329311 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1293790 Thu, 06 Mar 2008 05:00:00 +0100 1293790 http://www.medworm.com/index.php?rid=1270314&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18308607%26dopt%3DAbstract Authors: Räkel A, Sheehy O, Rahme E, Lelorier J Both diabetes and fractures are prevalent in adults. The relationship between diabetes and osteoporosis is complex and, although it has been investigated extensively, the subject remains controversial. While low bone mineral density (BMD) is consistently observed in type 1 diabetes, the relationship is less clear in type 2 diabetes, with some studies reporting modestly increased or unchanged BMD. Both type 1 and type 2 diabetes have been associated with a higher risk of fractures. Despite discrepancies between BMD and fracture rates, clinical trials uniformly support the fact that new bone formation and bone microarchitecture and, thus, bone quality, are altered in both types of diabetes. Although a causal association between diabete... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1270314 Tue, 26 Feb 2008 05:00:00 +0100 1270314 http://www.medworm.com/index.php?rid=1267904&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18304854%26dopt%3DAbstract CONCLUSIONS: Compared with other European countries, elevated blood pressure is more frequent in people with diabetes living in France; compared with US estimates, the prevalence of macrovascular complications is lower, glucose control better and blood pressure control poorer in France. These data, observed in a country with widespread access to care and at low cost to the patient, nevertheless demonstrate an urgent need for improving the cardiovascular risk profile of people with type1 and type2 diabetes, both with and without macrovascular complications. PMID: 18304854 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1267904 Mon, 25 Feb 2008 05:00:00 +0100 1267904 http://www.medworm.com/index.php?rid=1251515&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18291699%26dopt%3DAbstract This report presents a critical assessment of the most frequently used clinical models as well as some of the more innovative approaches. PMID: 18291699 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1251515 Tue, 19 Feb 2008 05:00:00 +0100 1251515 http://www.medworm.com/index.php?rid=1251514&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18291700%26dopt%3DAbstract CONCLUSION: PMBCs from type 2 diabetic patients with late diabetic complications exhibit high mtDNA oxidative damage. The degree of mtDNA oxidation was associated with an increase in MnSOD as an adaptive response to oxidative stress. The consequences of mtDNA oxidative damage on PBMC function and the progression of diabetic complications remain to be elucidated. PMID: 18291700 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1251514 Tue, 19 Feb 2008 05:00:00 +0100 1251514 http://www.medworm.com/index.php?rid=1249777&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18289908%26dopt%3DAbstract This study was designed to investigate the association between visceral and subcutaneous fat and cardiometabolic risk factors, in obese Korean adolescents. The study enrolled 175 adolescents (72 boys, 103 girls), from ages nine to 19 years, who were referred to the Obesity Clinic of Asan Medical Center. Body mass index (BMI) and waist circumference (WC) were measured for each study participant. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were calculated by computed tomography. Blood pressure, fasting plasma glucose, total cholesterol, triglycerides, HDL cholesterol, insulin and homeostasis model assessment (HOMA) score were measured. Systolic blood pressure, HDL cholesterol, fasting insulin and the HOMA score were significantly correlated with BMI, WC, VAT and... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1249777 Mon, 18 Feb 2008 05:00:00 +0100 1249777 http://www.medworm.com/index.php?rid=1249776&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18289909%26dopt%3DAbstract CONCLUSION: This 'pump' registry establishes the effectiveness of CSII in everyday practice, yet underscores the risks of severe hypoglycaemia and ketosis episodes. It could help diabetologists to improve patient training programmes and follow-up. PMID: 18289909 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1249776 Mon, 18 Feb 2008 05:00:00 +0100 1249776 http://www.medworm.com/index.php?rid=1243295&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18249023%26dopt%3DAbstract CONCLUSION: CT coronary angiography appears to have great potential for patients at risk where non-invasive tests cannot absolutely exclude coronary disease and for the follow-up of coronary bypass surgery. PMID: 18249023 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1243295 Fri, 01 Feb 2008 05:00:00 +0100 1243295 http://www.medworm.com/index.php?rid=1185473&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18222103%26dopt%3DAbstract CONCLUSION: Overall, our data suggest that HFHSD-induced diabetes is not associated with adiponectin deficiency, but with tissue-specific defects of adiponectin-receptor expression and AMPK activity. PMID: 18222103 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1185473 Wed, 23 Jan 2008 05:00:00 +0100 1185473 http://www.medworm.com/index.php?rid=1169030&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18206413%26dopt%3DAbstract CONCLUSIONS: The estimation of MODD from four pre-meal BG values correlated to that from CGM, and may represent a simple index of day-to-day glycaemic variability. High day-to-day glucose variability in glucose profile is frequently observed in diabetic children attending summer camp. PMID: 18206413 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1169030 Wed, 16 Jan 2008 05:00:00 +0100 1169030 http://www.medworm.com/index.php?rid=1046443&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18032083%26dopt%3DAbstract CONCLUSIONS: Partial replacement with a morning dose of insulin glargine protects against the development of ketosis for as much as 12 h after postprandial interruption of CSII. This treatment strategy could, therefore, be useful for patients who are prone to ketosis but, for other reasons, are deemed suitable for CSII. PMID: 18032083 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=1046443 Mon, 19 Nov 2007 05:00:00 +0100 1046443 http://www.medworm.com/index.php?rid=732407&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17625942%26dopt%3DAbstract CONCLUSION: The prevalence of DR in these young patients was low compared to that reported in previous studies. The decrease may be due to modern diabetes care with multiple insulin injections. However, early detection of DR in adolescents, especially in their late teens, remains important, because it allows the identification of patients at high risk of progression towards severe stages of DR. PMID: 17625942 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=732407 Mon, 09 Jul 2007 04:00:00 +0100 732407 http://www.medworm.com/index.php?rid=724268&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17616474%26dopt%3DAbstract Authors: Lupi R, Del Guerra S, Mancarella R, Novelli M, Valgimigli L, Pedulli GF, Paolini M, Soleti A, Filipponi F, Mosca F, Boggi U, Del Prato S, Masiello P, Marchetti P Oxidative stress is a putative mechanism leading to beta-cell damage in type 2 diabetes. We studied isolated human pancreatic islets from type 2 diabetic and non-diabetic subjects, matched for age and body mass index. Evidence of increased oxidative stress in diabetic islets was demonstrated by measuring nitrotyrosine concentration and by electron paramagnetic resonance. This was accompanied by reduced glucose-stimulated insulin secretion, as compared to non-diabetic islets (Stimulation Index, SI: 0.9+/-0.2 vs. 2.0+/-0.4, P<0.01), and by altered expression of insulin (approximately -60%), catalase (approximately +9... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=724268 Fri, 06 Jul 2007 04:00:00 +0100 724268 http://www.medworm.com/index.php?rid=717625&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17611136%26dopt%3DAbstract CONCLUSION: Our results show the need for a targeted prevention of overweight. We offer a proposal based on education and behaviour modification in La Reunion Island. PMID: 17611136 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=717625 Mon, 02 Jul 2007 04:00:00 +0100 717625 http://www.medworm.com/index.php?rid=717624&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17611137%26dopt%3DAbstract Authors: Bauduceau B, Vachey E, Mayaudon H, Burnat P, Dupuy O, Garcia C, Ceppa F, Bordier L The disorder now known as metabolic syndrome has been recognized for 50 years, but its multiple definitions have led to some confusion and even doubt about its very nature. Metabolic syndrome is directly linked to the presence of android obesity, which indicates insulin resistance and lies at the root of all risk factors and early indications of type 2 diabetes. It is diagnosed by systematic measurements of waist size and its direct interpretation taking ethnic origin into account. This pragmatic approach avoids the uncertainties generated by differing definitions and is subtler than the presence or absence of metabolic syndrome in a given patient. Drug-free treatment of an android obese patient... Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=717624 Mon, 02 Jul 2007 04:00:00 +0100 717624 http://www.medworm.com/index.php?rid=691757&cid=s_33003_15_f&fid=33003&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17584514%26dopt%3DAbstract CONCLUSIONS: Compared with human islets, in vitro insulin secretion by adult pig islets is characterized by a different kinetics and a major quantitative deficiency that can be corrected by cAMP. PMID: 17584514 [PubMed - as supplied by publisher] (Source: Diabetes Metab) Diabetes Metab journals http://www.medworm.com/rss/comments.php?id=691757 Tue, 19 Jun 2007 04:00:00 +0100 691757