MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diabetes Research and Clinical Practice' source. Wed, 08 Feb 2012 15:08:53 +0100 http://www.medworm.com/index.php?rid=5648779&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822712000629%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648779 Wed, 01 Feb 2012 05:00:00 +0100 5648779 http://www.medworm.com/index.php?rid=5648796&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822712000319%2Fabstract%3Frss%3Dyes Securing political priority for diabetes has long been an issue for the global diabetes community. We have seen a ‘diabetes paradox’ on the international agenda; while the disease is epidemic in scale, constitutes a vast economic burden and leads to more deaths than AIDs and malaria combined, it has not commanded political attention or sufficient resources on the global stage. However, the recent focus on Non-Communicable Diseases (NCDs) has meant global health priorities are finally realigning with the reality of the burden of disease. IDF has led the campaign to address the chronic neglect of diabetes; after gaining political recognition that diabetes is a “chronic, debilitating and costly disease” with the 2006 UN Resolution on diabetes , IDF secured international political acti... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648796 Mon, 16 Jan 2012 05:00:00 +0100 5648796 http://www.medworm.com/index.php?rid=5544855&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006681%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544855 Wed, 28 Dec 2011 11:19:32 +0100 5544855 http://www.medworm.com/index.php?rid=5544881&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006590%2Fabstract%3Frss%3Dyes 2011 was undoubtedly a landmark year for diabetes and global health more broadly. The UN High-Level Summit on Non-communicable Diseases (NCDs), held on the 19th–20th September 2011 in New York, changed the global health and development landscape forever. Diabetes and NCDs finally reached prominence when 193 UN Member States adopted the Political Declaration on NCDs and agreed to a set of commitments that has the potential to accelerate coordinated global progress that has been lacking for so long. As one of the earliest voices to call for the Summit and an instrumental player during preparations, the International Diabetes Federation (IDF) is proud to have been at the heart of this sea change. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544881 Fri, 16 Dec 2011 05:00:00 +0100 5544881 http://www.medworm.com/index.php?rid=5477089&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006322%2Fabstract%3Frss%3Dyes Every two years the International Diabetes Federation stages the world diabetes congress, a unique gathering when the global diabetes community comes together to learn about the latest diabetes research and scientific advances, exchange good practice on diabetes prevention, management and education, and share experiences on life with diabetes. This December's congress will take place in Dubai, chosen because of the very high prevalence of diabetes in the Gulf region and our intention that the congress will leave a positive legacy for people in that region and beyond. The timing of this congress is also significant since it comes in the wake of the UN High-Level Summit on NCDs. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477089 Thu, 01 Dec 2011 05:00:00 +0100 5477089 http://www.medworm.com/index.php?rid=5477073&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005626%2Fabstract%3Frss%3Dyes Abstract: Aims: To determine the effects on quality of life after starting insulin with, or switching to, insulin analogue therapies in the 24-week, prospective, non-interventional, observational A1chieve study conducted across four continents in people with type 2 diabetes.Methods: Health-related quality of life (HRQoL) was assessed at baseline and at 24weeks by the validated EQ-5D questionnaire (visual analogue score [VAS] and five dimensions) in 66,726 people who had started using basal insulin detemir, mealtime insulin aspart (with or without a basal insulin) or biphasic insulin aspart 30.Results: For the overall cohort, reported HRQoL increased significantly by 13.8 points from 63.4 points at baseline to 77.2 points at 24weeks (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477073 Thu, 01 Dec 2011 05:00:00 +0100 5477073 http://www.medworm.com/index.php?rid=5477072&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005638%2Fabstract%3Frss%3Dyes Conclusions: Beginning insulin analogue therapy in people with type 2 diabetes and poor blood glucose control is associated with marked improvements in diverse aspects of vascular risk factor profile without evidence of clinically significant safety or tolerability problems. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477072 Thu, 01 Dec 2011 05:00:00 +0100 5477072 http://www.medworm.com/index.php?rid=5477067&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006619%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477067 Thu, 01 Dec 2011 05:00:00 +0100 5477067 http://www.medworm.com/index.php?rid=5477066&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005754%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477066 Thu, 01 Dec 2011 05:00:00 +0100 5477066 http://www.medworm.com/index.php?rid=5648800&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006012%2Fabstract%3Frss%3Dyes Abstract: We designed a safe minimalistic model of GDM management which could be conveniently implemented in resource-constrained settings in developing countries. Pregnancy outcomes in the normal controls and the treated GDM patients were similar. We showed that, with minimal care delivered in a consistent fashion it was possible to obtain excellent pregnancy outcomes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648800 Wed, 30 Nov 2011 05:00:00 +0100 5648800 http://www.medworm.com/index.php?rid=5648795&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006024%2Fabstract%3Frss%3Dyes In conclusion, diabetes risk scoring models could not always be generalized from one population to another before validation. Asian models might be more suitable for Asian populations than non-Asian models, and prospective models might be more suitable for predicting future diabetes than cross-sectional models. When applied to our population, a prospective model from Taiwan performed best, and widespread application might be considered in the population. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648795 Wed, 30 Nov 2011 05:00:00 +0100 5648795 http://www.medworm.com/index.php?rid=5648802&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006103%2Fabstract%3Frss%3Dyes Abstract: We conducted a six-month randomized-controlled-trial to evaluate the effectiveness of a colour-coded HbA1c-graphical record in improving HbA1c level among type 2 diabetes patients. There was an improvement in the mean HbA1c knowledge score but the usage of the colour-coded HbA1c-graphical record did not produce reduction in the HbA1c level. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648802 Mon, 28 Nov 2011 05:00:00 +0100 5648802 http://www.medworm.com/index.php?rid=5648801&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006115%2Fabstract%3Frss%3Dyes Abstract: We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648801 Mon, 28 Nov 2011 05:00:00 +0100 5648801 http://www.medworm.com/index.php?rid=5648798&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005948%2Fabstract%3Frss%3Dyes Clinical guidelines for molecular diagnosis of monogenic forms of diabetes have been recently published . Maturity-onset diabetes of the young (MODY) prevalence in Caucasian population is estimated to be less than 5% in patients with type 2 diabetes diagnosis . (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648798 Mon, 28 Nov 2011 05:00:00 +0100 5648798 http://www.medworm.com/index.php?rid=5648794&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005675%2Fabstract%3Frss%3Dyes Conclusions: Introducing HbA1c into the diagnosis allowed detection of many previously undiagnosed cases of diabetes in Japanese individuals. Those diagnosed by FPG were characterized by hypertension and those diagnosed by HbA1c had unfavorable lipid profiles, reflecting an atherosclerotic trait. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648794 Mon, 21 Nov 2011 05:00:00 +0100 5648794 http://www.medworm.com/index.php?rid=5648791&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006000%2Fabstract%3Frss%3Dyes Conclusions: Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648791 Mon, 21 Nov 2011 05:00:00 +0100 5648791 http://www.medworm.com/index.php?rid=5477069&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711006036%2Fabstract%3Frss%3Dyes Conclusion: Diabetes prevalence estimates are very sensitive to the data from which they are derived. The revised IDF methodology for estimating diabetes prevalence is a transparent, reproducible approach that will be updated annually. It takes data-driven approaches to filling in gaps where data are not available and where assumptions have to be made. It uses a qualification system to rank data sources so that only the highest quality data are used. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477069 Mon, 21 Nov 2011 05:00:00 +0100 5477069 http://www.medworm.com/index.php?rid=5648799&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100550X%2Fabstract%3Frss%3Dyes Abstract: Cervical necrotizing fasciitis and a descending mediastinal abscess of the neck following acute epiglottitis, life-threatening complications, is reported in a 43-year-old man with DM. The bacterial culture showed Peptostreptococcus anaerobius. The patient recovered after surgical debridement and broad-spectrum antibiotics therapy. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648799 Wed, 16 Nov 2011 05:00:00 +0100 5648799 http://www.medworm.com/index.php?rid=5648792&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005870%2Fabstract%3Frss%3Dyes Conclusion: Wider retinal arteriolar calibre is independently associated with an increased risk of diabetes, supporting a possible role for early arteriolar changes in diabetes development. This effect was largely seen in Caucasians, and not in other ethnic groups, and may reflect ethnic differences in susceptibility to diabetes from microvascular pathways. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648792 Wed, 16 Nov 2011 05:00:00 +0100 5648792 http://www.medworm.com/index.php?rid=5648790&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005882%2Fabstract%3Frss%3Dyes Conclusion: Cardiac dysfunction of obese rats could be improved by reducing FFAs level. Intramyocardial lipid accumulation may increase the risk of heart failure in obese rats by increasing renin–angiotensin systems activity and protein levels of NF-κB and iNOS in myocardium. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648790 Wed, 16 Nov 2011 05:00:00 +0100 5648790 http://www.medworm.com/index.php?rid=5544876&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100547X%2Fabstract%3Frss%3Dyes Abstract: Although the clinical manifestations of type 2 diabetic nephropathy and decline in kidney function are similar to those in type 1, the clinical course and the renal structural changes are more heterogeneous in type 2 diabetic patients. Previous studies have shown that an increased urine IgM excretion in patients with type 1 diabetic nephropathy was associated with poor outcome. In the present follow-up study we examine the prognostic value of baseline urine IgM excretion in patients with type 2 diabetes mellitus.Methods: A cohort of 106 (74 male and 32 female) patients with type 2 diabetes regularly attending our diabetes out-patient clinic at Skane University Hospital in Lund. They were recruited prospectively under the period between 1992 and 2004. Patients were followed-up unt... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544876 Mon, 14 Nov 2011 05:00:00 +0100 5544876 http://www.medworm.com/index.php?rid=5477068&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005912%2Fabstract%3Frss%3Dyes Discussion: This paper builds on previous IDF estimates and shows that the global diabetes epidemic continues to grow. Recent studies show that previous estimates have been very conservative. The new IDF estimates use a simple and transparent approach and are consistent with recent estimates from the Global Burden of Disease study. IDF estimates will be updated annually. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477068 Mon, 14 Nov 2011 05:00:00 +0100 5477068 http://www.medworm.com/index.php?rid=5648793&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005651%2Fabstract%3Frss%3Dyes Conclusions: Our meta-analyses of cross-sectional studies found that adult cancer survivors with hematologic malignancies were at an increased risk of metabolic syndrome. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648793 Fri, 11 Nov 2011 05:00:00 +0100 5648793 http://www.medworm.com/index.php?rid=5648789&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005687%2Fabstract%3Frss%3Dyes Conclusion: The increased glycosylation seems to induce oxidative damage in the DNA of the diabetic patients, which manifests as an increased micronuclei frequency. This has a potential to be used as a biomarker for subsequent diabetic complications. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648789 Fri, 11 Nov 2011 05:00:00 +0100 5648789 http://www.medworm.com/index.php?rid=5544857&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003044%2Fabstract%3Frss%3Dyes Abstract: Aims: Assess safety and glycaemic control in patients initiating insulin with, or switching from basal insulin to, biphasic insulin aspart 30/70 (BIAsp 30) in primary care in Finland.Methods: A non-randomised, non-interventional, open-label, 26-week study of type 2 diabetes (T2D) patients prescribed BIAsp 30 by their physician, who determined starting dose, titration and injection frequency.Results: 496 patients provided safety data (insulin-naïve n=197; prior insulin n=299 [84.9% received NPH insulin]). Three patients (0.6%) reported four SADRs (three hypoglycaemia, one hypoglycaemia with unconsciousness). HbA1c was significantly (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544857 Fri, 11 Nov 2011 05:00:00 +0100 5544857 http://www.medworm.com/index.php?rid=5544889&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100564X%2Fabstract%3Frss%3Dyes Abstract: We investigated the relationship between intracoronary stenosis detected by multislice computed tomography and various clinical parameters in type 2 diabetic patients with hypertension treated with candesartan (n=42). The results showed that carotid intima-media thickness, but not visceral fat area or adiponectin, correlated significantly with intracoronary stenosis (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544889 Wed, 09 Nov 2011 05:00:00 +0100 5544889 http://www.medworm.com/index.php?rid=5544879&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005614%2Fabstract%3Frss%3Dyes Conclusions: Results from this study indicate that self-rated diabetes control has associations with diabetes-specific self-care behaviours and outcomes, and is a general indicator of self-care and diabetes-related complications in a population-based survey. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544879 Wed, 09 Nov 2011 05:00:00 +0100 5544879 http://www.medworm.com/index.php?rid=5544860&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005602%2Fabstract%3Frss%3Dyes Abstract: Aim: The Diabcare Africa project was carried out across six sub-Saharan African countries to collect standardised and comparable information for the evaluation of diabetes control, management and late complications in diabetic populations at specialist clinics.Methods: A cross-sectional, descriptive study of 2352 type-2 diabetes patients who were treated at specialist clinics for at least 12months prior to the study.Results: The mean age of patients was 53.0±16.0years and had 8.0±6.0years known duration of diabetes. 47% had their HbA1c assessed in the past year (mean 8.2±2.4%) with 29% achieving a level (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544860 Wed, 09 Nov 2011 05:00:00 +0100 5544860 http://www.medworm.com/index.php?rid=5544886&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005304%2Fabstract%3Frss%3Dyes Abstract: In 518 consecutive STEMI non-diabetic patients, glycated hemoglobin>6.5% was not associated with increased short and long term mortality, but was associated with higher admission glucose values, worse in-hospital glycemic control and a higher incidence of acute insulin resistance (HOMA index). (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544886 Mon, 07 Nov 2011 05:00:00 +0100 5544886 http://www.medworm.com/index.php?rid=5544880&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005596%2Fabstract%3Frss%3Dyes Conclusions: In utero hyperinsulinemia appears to increase the offspring's arterial stiffness at early adolescence. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544880 Mon, 07 Nov 2011 05:00:00 +0100 5544880 http://www.medworm.com/index.php?rid=5544872&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005493%2Fabstract%3Frss%3Dyes Abstract: Studies investigating the association of methylenetetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathy have so far reported inconclusive results. We therefore aim to address this inconclusiveness by conducting a meta-analysis. Random-effects model was applied irrespective of between-study heterogeneity. Data and study quality were assessed in duplicate. A total of 7807 and 1599 subjects from 21 and 8 studies were analyzed for diabetic nephropathy and diabetic retinopathy, respectively. Carriers of 677TT genotype were 1.71 (95% confidence interval [95% CI]: 1.02–2.88; P=0.042) and 2.89 (95% CI: 1.51–5.53; P=0.001) times more likely to develop diabetic nephropathy separately relative to diabetic patients without nephropa... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544872 Mon, 07 Nov 2011 05:00:00 +0100 5544872 http://www.medworm.com/index.php?rid=5409187&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005560%2Fabstract%3Frss%3Dyes Abstract: Aim: To describe coverage, cost and care of type 1 diabetes (T1D) in 2 regions of China – Beijing and Shantou – including:Methods: This is a mixed-methods descriptive study with three arms – coverage, cost and care. It is taking place in 4 tertiary hospitals, 3 secondary hospitals and 4 primary health facilities in Beijing, and 2 tertiary hospitals, 2 secondary hospitals and 2 primary health centres in Shantou, China. Two additional hospitals are involved in the coverage arm of the study. T1D participants are recruited from a 3-year list generated by each hospital and from those attending the outpatient clinic or admitted to the inpatient ward. Participants also include health care professionals and government officials. To determine coverage of care, a list of people with ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409187 Mon, 07 Nov 2011 05:00:00 +0100 5409187 http://www.medworm.com/index.php?rid=5409186&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005559%2Fabstract%3Frss%3Dyes The UN High-Level Summit on Non Communicable Diseases (NCDs), held in New York on the 19–20th September 2011, marked the beginning of a new era for diabetes. The world's 193 governments agreed the first ever Political Declaration on NCDs, recognising the magnitude and impact of the NCD problem, and agreeing to act. The UN Summit marked a political step change for diabetes, but it was only the beginning, not the end, of the campaign to confront the diabetes epidemic. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409186 Mon, 07 Nov 2011 05:00:00 +0100 5409186 http://www.medworm.com/index.php?rid=5648785&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005456%2Fabstract%3Frss%3Dyes Conclusions: These results suggest that motivational intervention is effective at changing cognitions but changing behaviour requires an intervention based on both motivation and volition. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648785 Fri, 04 Nov 2011 04:00:00 +0100 5648785 http://www.medworm.com/index.php?rid=5544888&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005511%2Fabstract%3Frss%3Dyes Abstract: We evaluated the efficacy and safety of sitagliptin after 3 months’ treatment in Japanese type 2 diabetic patients and examined changes in clinical factors. Baseline HbA1c, PPG, BMI, and duration of diabetes may be predictors of HbA1c reduction when using sitagliptin in Japanese type 2 diabetic patients. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544888 Fri, 04 Nov 2011 04:00:00 +0100 5544888 http://www.medworm.com/index.php?rid=5544873&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005468%2Fabstract%3Frss%3Dyes Conclusion: Patients with the HNF-1β mutation in our population can have different pancreatic and extrapancreatic phenotypes. The exact contributions of mutations to the phenotypes await functional confirmation. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544873 Thu, 03 Nov 2011 04:00:00 +0100 5544873 http://www.medworm.com/index.php?rid=5458478&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005134%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5458478 Tue, 01 Nov 2011 04:00:00 +0100 5458478 http://www.medworm.com/index.php?rid=5409164&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005134%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409164 Tue, 01 Nov 2011 04:00:00 +0100 5409164 http://www.medworm.com/index.php?rid=5648788&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005389%2Fabstract%3Frss%3Dyes Abstract: Background: The aim of this study is to compare the effect of physical exercise program on the endothelial function of patients with metabolic syndrome and type 2 diabetes mellitus.Methods: Patients were randomized for high intensity aerobic training (HI: 80% maximum heart rate, n=10), low intensity aerobic training (LI: 55% of maximum heart rate, n=10) and control (n=11). Before and after 6 weeks of training, subjects performed the maximal exercise test and a study of the endothelial function, through a high resolution ultrasound of the brachial artery, which was assessed after reactive hyperemia (endothelium dependent vasodilation) and nitrate administration (endothelium independent vasodilation).Results: A total of 31 patients with metabolic syndrome and type 2 diabetes mellit... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648788 Mon, 31 Oct 2011 04:00:00 +0100 5648788 http://www.medworm.com/index.php?rid=5648786&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005444%2Fabstract%3Frss%3Dyes Abstract: This exploratory study examines what Health Care Professionals (HCPs) working with diabetes patients, understand by the term ‘empowerment’, their attitudes towards it and whether they believe they practise in ways consistent with empowerment principles. A small sample of diabetes HCPs (N=13), from National Health Service (NHS) hospital, walk-in and General Practitioner (GP) clinics in South-East England, was interviewed. In-depth semi-structured interviews established attitudes towards and use of empowerment in day-to-day practice. Interviews were recorded, transcribed verbatim and analysed thematically. There was no clear specific understanding of what empowerment is and what it involves, although there was broad reporting of factors around education and informed choices. Di... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648786 Mon, 31 Oct 2011 04:00:00 +0100 5648786 http://www.medworm.com/index.php?rid=5648787&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005390%2Fabstract%3Frss%3Dyes Conclusions: PDK4 polymorphisms may not be associated with type 2 diabetes or metabolic syndrome. Further studies utilizing a larger study population are required to confirm these results. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648787 Mon, 24 Oct 2011 04:00:00 +0100 5648787 http://www.medworm.com/index.php?rid=5648780&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005250%2Fabstract%3Frss%3Dyes Abstract: Asia bears the world's greatest burden of type 2 diabetes (T2DM) and prevalence is increasing rapidly. Compared to other races, Asians develop T2DM younger, at a lower degree of obesity, suffer longer from its complications and die earlier. Curbing this epidemic requires an integrated, risk-based, and multidisciplinary approach. Inadequately managed T2DM has macrovascular and microvascular sequelae, Asians with T2DM being particularly susceptible to diabetic nephropathy. Earlier and more intensive monitoring and management of risk factors are required, especially for patients with, or at risk of, renal impairment. Particular challenges of T2DM management in Asia include: lack of access to specialist healthcare, insufficient clinical evaluation and delayed diagnosis. As in Caucasi... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648780 Mon, 24 Oct 2011 04:00:00 +0100 5648780 http://www.medworm.com/index.php?rid=5544887&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005341%2Fabstract%3Frss%3Dyes Abstract: An assay of plasma 1,5-anhydroglucitol was evaluated. Assay CVs, effects of four plasma freeze–thaw cycles, glucose up to 80mmol/L and triglycerides up to 20mmol/L were acceptable. 1,5-anhydroglucitol levels were significantly lower in diabetic vs. non-diabetic subjects and correlated inversely with renal function, but not with HbA1c. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544887 Mon, 24 Oct 2011 04:00:00 +0100 5544887 http://www.medworm.com/index.php?rid=5544878&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005407%2Fabstract%3Frss%3Dyes Conclusions: Staphylococcus aureus was the most common cause of DFIs in our area. Prevalence and precocity of MDR organisms, namely MRSA, were high and were probably related to previous indiscriminate antibiotic use. Clinicians should avoid fluoroquinolones and more frequently consider the use of empirical anti-MRSA therapy. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544878 Mon, 24 Oct 2011 04:00:00 +0100 5544878 http://www.medworm.com/index.php?rid=5544877&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005420%2Fabstract%3Frss%3Dyes Conclusions: No elevated risk of abnormal glucose regulation was observed for deviating scores on personality scales. Instead, reduced risks were indicated in men with low antagonism, and in men and women with high hedonic capacity. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544877 Mon, 24 Oct 2011 04:00:00 +0100 5544877 http://www.medworm.com/index.php?rid=5544875&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005432%2Fabstract%3Frss%3Dyes Abstract: Aim: To investigate circulating visfatin and vaspin levels in first-degree relatives of subjects with type 2 diabetes mellitus (FDRs) who frequently have higher value of HOMA-IR and beta cell dysfunction.Methods: Serum visfatin and vaspin concentrations were measured in 179 Iranian subjects (90 normoglycemic FDRs and 89 age- and sex-matched healthy controls) using enzyme-linked immunosorbent assay (ELISA) methods.Result: Serum visfatin levels were significantly lower in the FDRs when compared to the controls (1.71±0.93ng/ml versus 2.69±2.02ng/ml, p=0.0001). However, no significant difference was found in serum vaspin concentrations between the FDRs and the controls (0.452±0.254ng/ml versus 0.409±0.275ng/ml, p>0.05). In multiple logistic regression analysis, the FDRs showed a ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544875 Mon, 24 Oct 2011 04:00:00 +0100 5544875 http://www.medworm.com/index.php?rid=5544874&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005328%2Fabstract%3Frss%3Dyes This study was carried out with the purpose of investigating the association between serum lactadherin, monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNFα) and carotid-femoral pulse wave velocity (PWV) in elderly patients with type 2 diabetes mellitus (T2DM).Methods: A total of 105 subjects including 27 T2DM patients without vascular complications (DM), 28 T2DM patients with vascular complications (DC), 25 elderly healthy volunteers (older) and 25 younger healthy volunteers (younger) were recruited into the study. Carotid-femoral PWV was measured using an automatic device. Serum lactadherin, MCP-1 and TNFα were determined by enzyme linked immunosorbent assay.Results: PWV and lactadherin, MCP-1 and TNFα were significantly higher in DM and DC groups than those o... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544874 Mon, 24 Oct 2011 04:00:00 +0100 5544874 http://www.medworm.com/index.php?rid=5544871&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100533X%2Fabstract%3Frss%3Dyes Conclusion: Higher urinary tubular damage markers were found in T2DM patients with GHF than the norm-GFR and control groups, probably a direct proof that GHF is a deleterious factor for diabetic nephropathy. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544871 Mon, 24 Oct 2011 04:00:00 +0100 5544871 http://www.medworm.com/index.php?rid=5477088&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005419%2Fabstract%3Frss%3Dyes Conclusion: Although this study is not a trial and thus not able to definitively state the proportions of diabetes deaths that could be averted by reducing mean BMI, this paper demonstrates that theoretically between 9% and 98% of deaths from diabetes could be prevented by tackling obesity in the Asia Pacific region. Preventing these deaths is likely to have an enormous positive social and economic impact, particularly in this region consisting of many low and middle-income countries. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477088 Mon, 24 Oct 2011 04:00:00 +0100 5477088 http://www.medworm.com/index.php?rid=5544884&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005274%2Fabstract%3Frss%3Dyes Abstract: We assessed prevalence of metabolic syndrome (MS) in rural women of Bangladesh using 1485 women aged ≥15years. The prevalence rate of MS was 31.25% (NCEP ATP III modified). And 85.05% population had low HDL values. These findings are important in the development of future health prevention strategies in Bangladesh. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544884 Thu, 20 Oct 2011 04:00:00 +0100 5544884 http://www.medworm.com/index.php?rid=5544883&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005286%2Fabstract%3Frss%3Dyes Abstract: We document the first reported case of fulminant diabetes, without evidence of pancreatic islet autoimmunity, in Australia in a woman of Chinese Vietnamese background. Fulminant diabetes occurs primarily in Asia, particularly in Japan, but with widespread population migration clinicians need to be aware of this form of diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544883 Wed, 19 Oct 2011 04:00:00 +0100 5544883 http://www.medworm.com/index.php?rid=5477087&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005183%2Fabstract%3Frss%3Dyes Abstract: Ninety seven patients with chronic hepatitis C (CHC) and 72 with non-alcoholic fatty liver disease (NAFLD) were enrolled. Increased visceral fat area (VFA) was associated with high values of HbA1c. The variables associated with a high risk of new-onset diabetes had a VFA>101cm2 in CHC, but not in NAFLD. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477087 Wed, 19 Oct 2011 04:00:00 +0100 5477087 http://www.medworm.com/index.php?rid=5648782&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005171%2Fabstract%3Frss%3Dyes Abstract: Aim: Our objective was to examine the cost-effectiveness of disease management programs (DMPs) for type 2 diabetes mellitus (T2DM) taking into account their life prolonging effect.Methods: We compared real life costs in 19,888 propensity score matched pairs of T2DM DMP participants and T2DM patients in routine care (RC) according to sickness funds data. We estimated mean annual costs for survivors, last year of life costs for decedents, the influence of ageing on costs, incremental cost-effectiveness ratio and effects on hospitalization.Results: Annual costs for survivors were 3,318€ (DMP) and 3,570€ (RC). The mean costs in the last year of life were 16,911€ (DMP) and 15,763€ (RC). Ageing had a cost triggering effect for survivors (30€/36€ per year in DMP-/RC-group; p... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648782 Mon, 17 Oct 2011 04:00:00 +0100 5648782 http://www.medworm.com/index.php?rid=5648781&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005237%2Fabstract%3Frss%3Dyes Abstract: Diabetes demands early diagnosis, prompt treatment, continuous monitoring and follow up. Physicians play a pivotal role in diabetes management. However, evidence suggests that sub-optimal knowledge of guidelines and other issues may lead to ineffective management and poor patient outcomes. The aim of this research was to identify clinical diabetologist's perspectives on evidence based diabetes management, benefits of and barriers to the practice of evidence based guidelines in management of type 2 diabetes. Clinical diabetologists were administered a semi-structured questionnaire. Qualitative responses were analysed to identify key words, phrases and concepts from respondents. Majority of diabetologist (78.2%) preferred ADA guidelines alone or in combination with others guideline... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648781 Mon, 17 Oct 2011 04:00:00 +0100 5648781 http://www.medworm.com/index.php?rid=5544870&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005201%2Fabstract%3Frss%3Dyes Conclusions: Glycation of DNA has resulted in structural perturbation causing generation of neo-antigenic epitopes that are better antigens for antibodies in diabetes patients. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544870 Mon, 17 Oct 2011 04:00:00 +0100 5544870 http://www.medworm.com/index.php?rid=5544869&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005213%2Fabstract%3Frss%3Dyes This study aimed to evaluate the effect of DNA vaccine in preventing late prediabetic nonobese diabetic (NOD) mice from developing autoimmune diabetes mellitus. The cDNA of human IA2 was recombined to be used as the DNA vaccine. Plasmid IL-4/MCP-1 was co-administrated as the DNA adjuvant. 49 10–11-week-old NOD mice were grouped into four groups: the control group (n=10), IA-2 vaccine group (n=17), IL-4/MCP-1 vaccine group (n=8) and IA-2 plus IL-4/MCP-1 vaccine group (n=14) by intramuscularly injected with 50μg plasmid in each quadriceps muscle. Glucose levels in the groups were detected every 1–2 weeks. Insulitis was evaluated with hematoxylin and eosin-stained pancreatic sections. CD4+ CD25+and CD8+ T lymphocytes were measured with flow cytometry. The results showed that in 10–11-w... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544869 Mon, 17 Oct 2011 04:00:00 +0100 5544869 http://www.medworm.com/index.php?rid=5544856&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005249%2Fabstract%3Frss%3Dyes Abstract: Metformin is a cornerstone in the treatment of type 2 diabetes. Although its mechanism of action is not well understood, there is new evidence about its possible role in cancer. A Pubmed search from 1990 to 2011 was done using the terms metformin, cancer, mechanism of action, diabetes treatment and prevention. We found more than one thousand articles and reviewed studies that had assessed the efficacy of metformin in treatment and prevention of type 2 diabetes and its mechanisms of actions, as well as articles on its antitumoral effects. We found that the United Kingdom Prospective Diabetes Study and the Diabetes Prevention Program have demonstrated the efficacy of metformin in terms of treatment and prevention of type 2 diabetes; metformin is safe, cost effective and remains the... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544856 Mon, 17 Oct 2011 04:00:00 +0100 5544856 http://www.medworm.com/index.php?rid=5544885&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005262%2Fabstract%3Frss%3Dyes Abstract: The association between depressive symptoms and patient–provider communication was examined in adult primary care patients with diabetes. Most communication was not patient-centered, but did not differ by level of patient's depressive symptoms. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544885 Fri, 14 Oct 2011 04:00:00 +0100 5544885 http://www.medworm.com/index.php?rid=5544882&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005225%2Fabstract%3Frss%3Dyes Abstract: Hemichorea is a rare complication of non-ketotic hyperglycaemia. Patients with this syndrome have classically longstanding, poorly controlled diabetes. Here, we report a patient presenting hemichorea without diabetic history. His symptom resolved rapidly after correction of hyperglycaemia. We suggest that hemichorea may be the first manifestation of undiagnosed diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544882 Fri, 14 Oct 2011 04:00:00 +0100 5544882 http://www.medworm.com/index.php?rid=5544859&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005195%2Fabstract%3Frss%3Dyes Conclusions: This study demonstrated that an acute exercise bout has positive influences on affect and psychological well-being. The usefulness of exercise to elevate affective responses (activation and pleasure) should be highlighted when promoting exercise interventions in subjects with type 2 diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544859 Fri, 14 Oct 2011 04:00:00 +0100 5544859 http://www.medworm.com/index.php?rid=5544865&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004840%2Fabstract%3Frss%3Dyes Conclusions: People with higher educational attainment may benefit to a greater extent from brief self-care interventions for diabetes, while those with lower educational attainment may require more intensive treatment. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544865 Thu, 13 Oct 2011 04:00:00 +0100 5544865 http://www.medworm.com/index.php?rid=5477070&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100489X%2Fabstract%3Frss%3Dyes Conclusion: The long-acting insulin analogues offer little to no clinical advantages over NPH insulin, and there is no significant difference in the efficacy and safety. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477070 Thu, 13 Oct 2011 04:00:00 +0100 5477070 http://www.medworm.com/index.php?rid=5477099&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004931%2Fabstract%3Frss%3Dyes Abstract: We conducted a meta-analysis to investigate the association between the −2518A/G polymorphism in the MCP-1 gene and the risk of diabetes. Ten case–control studies were included in this meta-analysis. Results indicated this polymorphism may be a risk factor for diabetes in Caucasians. Future studies are needed to validate our conclusions. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477099 Wed, 12 Oct 2011 04:00:00 +0100 5477099 http://www.medworm.com/index.php?rid=5477071&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005146%2Fabstract%3Frss%3Dyes Abstract: The hyperglycemic emergencies, diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are potentially fatal complications of uncontrolled diabetes mellitus. The incidence of DKA and the economic burden of its treatment continue to rise, but its associated mortality rate which was uniformly high has diminished remarkably over the years. This Improvement in outcome is largely due to better understanding of the pathogenesis of hyperglycemic emergencies and the application of evidence-based guidelines in the treatment of patients. In this article, we present a critical review of the evidence behind the recommendations that have resulted in the improved prognosis of patients with hyperglycemic crises. A succinct discussion of the pathophysiology and important etiologic... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477071 Wed, 05 Oct 2011 04:00:00 +0100 5477071 http://www.medworm.com/index.php?rid=5348464&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100516X%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348464 Wed, 05 Oct 2011 04:00:00 +0100 5348464 http://www.medworm.com/index.php?rid=5544863&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100492X%2Fabstract%3Frss%3Dyes Conclusions: Specific cognitive abilities, particularly planning and problem solving, play an independent role in diabetes self-management behaviors. Assessing patients’ cognitive abilities may be of value for adjusting self-management education and treatment regimen. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544863 Mon, 03 Oct 2011 04:00:00 +0100 5544863 http://www.medworm.com/index.php?rid=5477083&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004918%2Fabstract%3Frss%3Dyes Abstract: Aims: We investigated whether differences in duration of first insulin use in type 2 diabetes remain after adjustment for potential confounders, and what factors are associated with longer use.Methods: People prescribed a first insulin (2000–2007) after 2–3 non-insulin glucose lowering treatments (OGLD) were identified from the THIN UK primary care database and grouped by insulin, detemir (n=165), glargine (n=1011) or NPH (n=420). Time from beginning insulin to the prescription of another insulin type or a glucagon-like peptide was compared between insulins in a Cox model adjusting for: demographics, HbA1c, history of vascular complications and cardiovascular risk factors. The strength of association between duration of use and these variables was investigated.Results: The ad... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477083 Mon, 03 Oct 2011 04:00:00 +0100 5477083 http://www.medworm.com/index.php?rid=5348441&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004712%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348441 Sat, 01 Oct 2011 04:00:00 +0100 5348441 http://www.medworm.com/index.php?rid=5544862&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004943%2Fabstract%3Frss%3Dyes Abstract: Aim: To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and arterial stiffness in patients with type 2 diabetes.Methods: Serum 25(OH)D was measured in a cross-sectional sample of 131 men and 174 women aged 30 years and over in Korea. Arterial stiffness was assessed by pulse wave velocity (PWV) obtained with a VP-2000 pulse wave unit. Fasting plasma glucose, insulin, lipid profile, HbA1c, calcium, phosphorous, and HS-CRP were measured.Results: The prevalence of vitamin D deficiency was high (85.9%). Those with lower vitamin D levels had increased PWV. Using multivariate regression analysis, low 25(OH)D concentrations independently predicted PWV (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544862 Fri, 30 Sep 2011 04:00:00 +0100 5544862 http://www.medworm.com/index.php?rid=5648784&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004980%2Fabstract%3Frss%3Dyes Conclusions: The implementation of a group-based, non-intensive dietary counseling proved to be practical and feasible in “real-world” community settings and was accompanied by favorable dietary changes and health benefits. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648784 Wed, 28 Sep 2011 04:00:00 +0100 5648784 http://www.medworm.com/index.php?rid=5648783&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711005158%2Fabstract%3Frss%3Dyes Conclusions: The Gas6 c.843+7AA genotype and A allele are less prevalent in type 2 diabetes, which may have a protective role for type 2 diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648783 Wed, 28 Sep 2011 04:00:00 +0100 5648783 http://www.medworm.com/index.php?rid=5477098&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004967%2Fabstract%3Frss%3Dyes Abstract: We prospectively evaluated the correlation between point-of-care β-OHB values and DKA severity at time of initial diagnosis in 54 patients. The correlation coefficients between β-OHB and pH, bicarbonate and anion gap were 0.33, 0.25 and 0.16, respectively. We conclude that point-of-care β-OHB absolute values cannot reliably assess DKA severity. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477098 Wed, 28 Sep 2011 04:00:00 +0100 5477098 http://www.medworm.com/index.php?rid=5477097&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004979%2Fabstract%3Frss%3Dyes Abstract: Perioperative glycaemic control during admission was a predictive factor of amputation in a prospective cohort of 81 patients with diabetes who underwent surgical treatment for osteomyelitis. Glycaemic control before admission, as determined by glycosylated haemoglobin, did not have any influence on the outcomes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477097 Wed, 28 Sep 2011 04:00:00 +0100 5477097 http://www.medworm.com/index.php?rid=5477086&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004992%2Fabstract%3Frss%3Dyes Abstract: Objective: To examine change of diagnosis in patients from the German/Austrian multicenter DPV (Diabetes Patienten Verlaufsdokumentation) database initially classified as type 2 diabetes.Methods: Patients aged ≤20 years at onset, diagnosed between 1995 and 2010 were followed for at least 6 months. Chi-square/Wilcoxon tests were performed to compare patient groups according to diabetes type after reclassification.Results: From 580 study patients, 60 (10.3%) were reclassified, on average 2.4 years after initial diagnosis as follows: 23 (38.3%) as type 1 diabetes; 9 (15%) as maturity onset diabetes of the young (MODY); 20 (33.3%) as “other specific diabetes forms” and 8 (13.3%) as “remission” of type 2 diabetes. Patients reclassified to type 1 were significantly younger (1... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477086 Wed, 28 Sep 2011 04:00:00 +0100 5477086 http://www.medworm.com/index.php?rid=5477084&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004906%2Fabstract%3Frss%3Dyes Conclusions: Metabolic responses after mixed or liquid meals of similar content were highly correlated in T2D and healthy subjects. In T2D, the liquid meal produced beta-cell function estimates generally similar to the mixed meal. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477084 Wed, 28 Sep 2011 04:00:00 +0100 5477084 http://www.medworm.com/index.php?rid=5544864&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004852%2Fabstract%3Frss%3Dyes Abstract: Aims: Our study addressed the influence of early inflammatory stages of diabetic kidney disease: leukocyte adhesion and monocyte activation (as assessed by intercellular leukocyte adhesion molecule-ICAM-1 and monocyte chemoatractant protein-MCP-1) on the degree of albuminuria. Plasma levels of adiponectin, a possible anti-inflammatory counteracting mechanism, were also studied in correlation to the above-mentioned cytokines.Methods: 79 consecutive type 2 diabetic outpatients and 46 controls were included. Routine laboratory analysis, urinary albumin to creatinine ratio (uACR), plasma adiponectin, plasma ICAM-1 and urinary MPC-1 were assessed.Results: In multiple regression ICAM-1 (p=0.004) and adiponectin (p=0.04) were the main determinants of uACR. Plasma adiponectin positively ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544864 Mon, 26 Sep 2011 04:00:00 +0100 5544864 http://www.medworm.com/index.php?rid=5477096&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004827%2Fabstract%3Frss%3Dyes Abstract: We assessed the oral glucose tolerance test's (OGTT) ability to produce consistent results for estimating insulin sensitivity over four consecutive days. Individual coefficients of variation for OGIS and Stumvoll-ISI were 7.8% and 14.4% with no statistically significant difference between days. Thereby, indicating repeated OGTT's are reliable for estimating insulin sensitivity. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477096 Mon, 26 Sep 2011 04:00:00 +0100 5477096 http://www.medworm.com/index.php?rid=5544866&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004839%2Fabstract%3Frss%3Dyes Conclusions: These findings may help clinicians identify subgroups of youth at-risk for poor diabetes management and provide further education in order to improve outcomes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544866 Thu, 22 Sep 2011 04:00:00 +0100 5544866 http://www.medworm.com/index.php?rid=5477095&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004645%2Fabstract%3Frss%3Dyes We examined a possible association between subclinical hypothyroidism and albuminuria in 159 people with type 2 diabetes. Patients with subclinical hypothyroidism had significantly higher levels of urinary albumin-to-creatinine ratio (UACR) than those with euthyroidism. Multivariate logistic regression analyses demonstrated that serum TSH level was an independent risk factor of albuminuria. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477095 Mon, 19 Sep 2011 04:00:00 +0100 5477095 http://www.medworm.com/index.php?rid=5477082&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004682%2Fabstract%3Frss%3Dyes Conclusions: Our results suggested that hyperinsulinemia and hyperleptinemia may be most important mechanisms in decreasing ghrelin and inducing oxidative stress in simple obese and T2DM obese patients. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477082 Mon, 19 Sep 2011 04:00:00 +0100 5477082 http://www.medworm.com/index.php?rid=5409185&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004657%2Fabstract%3Frss%3Dyes Conclusions: MetS has a strong association with incident diabetes. Of the individual components, hyperglycemia is the strongest predictor of diabetes. Additional numbers of metabolic components increase the risk of developing diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409185 Thu, 15 Sep 2011 04:00:00 +0100 5409185 http://www.medworm.com/index.php?rid=5477081&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004815%2Fabstract%3Frss%3Dyes Conclusions: Elevated hsCRP levels could be predictors of progression to T2DM later in life in patients with GDM. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477081 Wed, 14 Sep 2011 04:00:00 +0100 5477081 http://www.medworm.com/index.php?rid=5544867&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004670%2Fabstract%3Frss%3Dyes Conclusions: The D-QOL scale is a simple and brief scale, the use of which is feasible in practice. It demonstrated excellent psychometric properties, and so may also be used in clinical research. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544867 Mon, 12 Sep 2011 04:00:00 +0100 5544867 http://www.medworm.com/index.php?rid=5544858&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100458X%2Fabstract%3Frss%3Dyes Conclusions: The prevalence of MS depends on the set of diagnostic criteria used. IDF criteria best predicts the presence of NAFLD. The presence of NAFLD should be considered as a component of the diagnostic criteria for MS. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544858 Mon, 12 Sep 2011 04:00:00 +0100 5544858 http://www.medworm.com/index.php?rid=5477094&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004608%2Fabstract%3Frss%3Dyes Abstract: We recorded self-reported eating patterns in 172 Japanese men and women who were subsequently followed for 3 years for the occurrence of impaired glucose tolerance (IGT).Incidence of IGT was significantly higher in those who reported eating fast. Self-reported eating fast is a potent risk factor for development of IGT. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477094 Mon, 12 Sep 2011 04:00:00 +0100 5477094 http://www.medworm.com/index.php?rid=5409181&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004669%2Fabstract%3Frss%3Dyes Abstract: Introduction: Post-marketing data on weight-loss medications in free living population are a necessary adjunct to data from clinical trials.Materials and methods: We conducted a population-based analysis of first-time medication users based on HMO pharmacy purchasing data serving>one million adults.Results: During 5 years, usage of orlistat and sibutramine more than doubled and rates were higher during the months May–Aug. As compared to non-users (n=1,038,828), annual weight-loss drug users (n=7175) had higher women proportion, body-mass-index (BMI), bariatric surgery history, and usage of diabetes, depression, and cardiovascular medications (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409181 Mon, 12 Sep 2011 04:00:00 +0100 5409181 http://www.medworm.com/index.php?rid=5477093&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004621%2Fabstract%3Frss%3Dyes Abstract: Rapid improvement in glycaemic control induced by GLP-1 agonist therapy could be yet another illustration of transient or permanent progression of diabetic retinopathy, similar to documented examples such as pregnancy and continuous subcutaneous insulin infusion. Specific guidelines would be needed to monitor this paradoxical phenomenon during treatment with GLP-1 agonists. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477093 Fri, 09 Sep 2011 04:00:00 +0100 5477093 http://www.medworm.com/index.php?rid=5648797&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100461X%2Fabstract%3Frss%3Dyes This study is part of the Chikushi Anti-diabetes Trials (CHAT) program and was approved by Ethics Commission of Fukuoka University Hospital and Fukuoka University Chikushi Hospital. After 24-week sitagliptin therapy, HbA1c was significantly reduced versus baseline from 7.9±0.1% to 7.3±0.1% (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5648797 Wed, 07 Sep 2011 04:00:00 +0100 5648797 http://www.medworm.com/index.php?rid=5544861&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004542%2Fabstract%3Frss%3Dyes Conclusions: Some patients with type 2 diabetes are receptive to motivational interviewing which is a provider approach that is more patient-centered and empowering than traditional care. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544861 Wed, 07 Sep 2011 04:00:00 +0100 5544861 http://www.medworm.com/index.php?rid=5477080&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004591%2Fabstract%3Frss%3Dyes In conclusions, the molecular mechanism by which SDEE inhibits iNOS gene expression appears to involve the inhibition of NF-κB activation. These results suggest the possible therapeutic value of S. draconis and could be potentially developed into a novel drug for preventing the progression of diabetes mellitus. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477080 Wed, 07 Sep 2011 04:00:00 +0100 5477080 http://www.medworm.com/index.php?rid=5477076&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004207%2Fabstract%3Frss%3Dyes Conclusions: Ethnic minority veterans with diabetes are less likely to have multiple cardiovascular risk factor control over time compared to whites. Thus, greater risk reduction efforts are needed to reduce the heavier disease burden among ethnic minorities. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477076 Wed, 07 Sep 2011 04:00:00 +0100 5477076 http://www.medworm.com/index.php?rid=5477091&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004517%2Fabstract%3Frss%3Dyes Abstract: We tested the relationship between plasma levels of dimethylarginines (ADMA and SDMA) and glycaemic control in 43 type 2 diabetic patients. Type 2 diabetics with poor glycaemic control (HbA1c>6.5) had significantly lower SDMA and higher ADMA concentrations than those with well-controlled glycaemia (HbA1c (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477091 Mon, 05 Sep 2011 04:00:00 +0100 5477091 http://www.medworm.com/index.php?rid=5477085&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004529%2Fabstract%3Frss%3Dyes Abstract: Aims: To observe temporal changes in the prevalence of diabetes, impaired fasting glucose and its associated risk factors in the rural area of Baluchistan province of Pakistan according to American Diabetes Association criteria by comparing the two surveys done in 2002 and 2009.Methodology: This community based survey of 1264 subjects aged 25 years and above was conducted from February 2009 to February 2010 in sixteen villages of southern Baluchistan. The temporal changes were assessed in comparison with a similar survey conducted seven years previously. Data from 2002 survey was also re-analyzed according to the latest ADA criteria.Results: A two-fold increase in the prevalence of diabetes (from 7.2% to 14.2%) was seen in 2009 survey and the prevalence of impaired fasting glucos... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477085 Mon, 05 Sep 2011 04:00:00 +0100 5477085 http://www.medworm.com/index.php?rid=5477079&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004232%2Fabstract%3Frss%3Dyes Abstract: Aims: To examine the relationship between vascular calcification in the foot (FVC) and bone mineral density (BMD) in the heel of type 2 diabetes mellitus (DM) subjects.Methods: 65 subjects with type 2 DM and serum creatinine (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477079 Mon, 05 Sep 2011 04:00:00 +0100 5477079 http://www.medworm.com/index.php?rid=5477077&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004190%2Fabstract%3Frss%3Dyes Abstract: Aims: The study was designed to compare a combined aerobic and resistance training (ART) with an aerobic training (AT) over hemodynamic, glucose metabolism and endothelial factors, adipokines and pro-inflammatory marker release in a population of obese type 2 diabetic patients.Methods: Forty-seven patients were randomly assigned to aerobic (27 patients) or aerobic plus resistance (20 patients) exercise trainings, on the top of a diet regime. Anthropometric, metabolic, hormonal and inflammatory variables were measured at hospitalization and discharge.Results: Both exercise programs equally improved body weight and fructosamine levels however ART only partially decreased HOMA index compared with AT (ART: −25% vs AT: −54%, p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477077 Mon, 05 Sep 2011 04:00:00 +0100 5477077 http://www.medworm.com/index.php?rid=5409180&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004530%2Fabstract%3Frss%3Dyes Abstract: Objective: To examine the trends in the prevalence of diabetes in patients who received medical care from the Louisiana State University Health Care Services Division (LSUHCSD) hospital system between 2000 and 2009.Methods: The study population included 969,609 unique outpatients and inpatients between 2000 and 2009. The diabetes cases were identified by using ICD-9 code (250*). The annual diabetes prevalence was calculated as the number of unique individuals with an ICD-9 diabetes during the year divided by the number of unique individuals visiting the LSUHCSD hospitals during the year.Results: The age-standardized prevalence of diabetes in LSUHCSC hospital patients aged ≥20 years increased by 36.2% during 2000–2009, from 10.5% to 14.3%. The rise in age-standardized prevalen... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409180 Mon, 05 Sep 2011 04:00:00 +0100 5409180 http://www.medworm.com/index.php?rid=5477090&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004220%2Fabstract%3Frss%3Dyes Abstract: It is likely that the C allele of the polymorphism at position 29 of the translated sequence of transforming growth factor (TGF)-β1 gene, which codes a pleiotropic cytokine expressed in a variety of cells, is a susceptibility allele for cerebral infarction in Japanese type 2 diabetic patients. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477090 Thu, 01 Sep 2011 04:00:00 +0100 5477090 http://www.medworm.com/index.php?rid=5477078&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004189%2Fabstract%3Frss%3Dyes Conclusions: There is evidence of a possible association between protein oxidation and decreased PON1 activity in GDM. The increase in protein oxidation parameters in the GDM group leading to decreased PON1 activity might, we think, create a predisposition for clinical complications in GDM group. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477078 Thu, 01 Sep 2011 04:00:00 +0100 5477078 http://www.medworm.com/index.php?rid=5226810&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004499%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226810 Thu, 01 Sep 2011 04:00:00 +0100 5226810 http://www.medworm.com/index.php?rid=5226809&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004281%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226809 Thu, 01 Sep 2011 04:00:00 +0100 5226809 http://www.medworm.com/index.php?rid=5477092&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004505%2Fabstract%3Frss%3Dyes Abstract: We estimated the risk-increasing role of late-diagnosis on the onset of complications among 1168 patients representative of above 50 Hungarian diabetic population. Higher occurrence of retinopathy has been found in the late-diagnosis group (OR=1.62, 95% CI: 1.06–2.49). Clinically significant benefit of early-diagnosis was not observable in case of other complications. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477092 Wed, 31 Aug 2011 04:00:00 +0100 5477092 http://www.medworm.com/index.php?rid=5544868&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100180X%2Fabstract%3Frss%3Dyes This study examined the long-term impact of a 24-month, empowerment-based diabetes self-management support (DSMS) intervention on sustaining health-gains achieved from previous diabetes self-management education (DSME).Methods: Prior to the intervention, all participants received 6 months of mailed DSME consisting of weekly educational newsletters coupled with clinical feedback. The intervention consisted of 88 weekly group-based sessions that participants were encouraged to attend as frequently as they needed. Sessions were guided by participants’ self-management questions and also emphasized experiential learning, coping, goal-setting, and problem-solving. Baseline, 6-month, and 30-month assessments measured A1C, weight, body mass index (BMI), blood pressure, lipids, self-care behavior... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5544868 Mon, 29 Aug 2011 04:00:00 +0100 5544868 http://www.medworm.com/index.php?rid=5477075&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004219%2Fabstract%3Frss%3Dyes Abstract: Aims: Hyperglycemia causes generation of free radicals which leads to oxidative stress and apoptosis in various cells. The present study was undertaken to investigate the correlation between oxidative stress and apoptotic markers in lymphocytes of diabetic patients with chronic non healing wounds.Methods: Thirty healthy, thirty uncontrolled type 2 diabetes mellitus (T2DM) and thirty uncontrolled T2DM with chronic, non healing, neuropathic diabetic foot patients were included in this study. Indices of oxidative stress inside the lymphocyte lysate were estimated by measuring content of superoxide dismutase (SOD), Catalase, Glutathione and malonaldialdehyde (MDA). Protein expression studies of pro and anti apoptotic markers were carried out to elucidate their possible involvement in... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477075 Mon, 29 Aug 2011 04:00:00 +0100 5477075 http://www.medworm.com/index.php?rid=5409173&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004116%2Fabstract%3Frss%3Dyes Abstract: Aim: To assess efficacy and safety of saxagliptin added to metformin versus placebo plus metformin in Asian patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control on metformin alone.Methods: Adults (HbA1c 7.0–10.0%, on stable metformin ≥1500mg/day) were randomized 1:1 to saxagliptin 5mg daily plus metformin (n=283) or placebo plus metformin (n=287). The primary end point was HbA1c change from baseline to Week 24.Results: Saxagliptin plus metformin provided significant adjusted mean decreases versus placebo plus metformin (p≤0.0052) in HbA1c (−0.78% versus −0.37%), fasting plasma glucose (−1.14mmol/L versus −0.58mmol/L), and postprandial glucose area under the curve from 0 to 180min (−315mmolmin/L versus −160mmolmin/L). Significantly more s... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409173 Mon, 29 Aug 2011 04:00:00 +0100 5409173 http://www.medworm.com/index.php?rid=5226833&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004578%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226833 Mon, 29 Aug 2011 04:00:00 +0100 5226833 http://www.medworm.com/index.php?rid=5409195&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004153%2Fabstract%3Frss%3Dyes We report a 18-month follow-up of switching from insulin to SU in a mother and her daughter with PNDM due to KCNJ11 mutation. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409195 Fri, 26 Aug 2011 04:00:00 +0100 5409195 http://www.medworm.com/index.php?rid=5409168&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004128%2Fabstract%3Frss%3Dyes Abstract: Aims: We aimed to assess changes in serum adiponectin and endothelial function after intensive insulin treatment in patients with newly diagnosed type 2 diabetes mellitus (T2DM).Methods: Patients with newly diagnosed T2DM were randomly assigned to Group A (intensive insulin treatment) or Group B (conventional insulin treatment). Before treatment and 2 weeks after plasma glucose concentrations had been maintained at the specified concentrations, blood samples were obtained to measure serum adiponectin and nitric oxide (NO) concentrations. A total of 21 patients were randomized to each Group.Results: Adiponectin, NO, endothelium-dependent vasodilation (EDD), and endothelium-independent vasodilation (EID) measures were significantly higher post-treatment than pre-treatment in Group ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409168 Fri, 26 Aug 2011 04:00:00 +0100 5409168 http://www.medworm.com/index.php?rid=5409184&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004086%2Fabstract%3Frss%3Dyes Abstract: Aims: To describe the relationship of retinal arteriolar and venular caliber with diabetes, retinopathy and hyperglycemia, in an Asian Indian population.Methods: This was a population-based cross-sectional study of 3400 (75.6% response rate) Singapore ethnic Indians aged 40–80 years. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were obtained using a validated computer-assisted program. Diabetes mellitus was identified using standardized criteria. Diabetic retinopathy was graded based on the modified Airlie House Classification System.Results: There were 980 (32.2%) participants with diabetes. Of these, 327 (33.4%) had diabetic retinopathy. After multivariate adjustment, diabetic persons had a wider CRAE (145.23μm vs 142.38μm, P (S... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409184 Wed, 24 Aug 2011 04:00:00 +0100 5409184 http://www.medworm.com/index.php?rid=5409183&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004049%2Fabstract%3Frss%3Dyes Abstract: Aims: We aimed to determine the associations between metformin or sulphonylurea monotherapy at study entry into the FIELD diabetes trial and (1) metabolic risk factors, (2) risk of a first major cardiovascular (CVD) outcome, and (3) the effect of each therapy on the risk-modifying effect of fenofibrate.Methods: Patients receiving metformin or sulphonylureas without insulin therapy were compared for the relative risk of CVD outcomes, adjusted for differences in baseline characteristics likely to affect risk.Results: Metformin-treated patients were likely to be younger, female, or obese. Metformin was associated with higher levels of lipids (other than LDL-C) and homocysteine (P (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409183 Wed, 24 Aug 2011 04:00:00 +0100 5409183 http://www.medworm.com/index.php?rid=5409177&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004037%2Fabstract%3Frss%3Dyes Abstract: Aberrant DNA methylation in T cells has been linked to pathogenesis of autoimmune diseases. To investigate genomic and gene-specific DNA methylation levels in CD4+ T cells from patients with latent autoimmune diabetes in adults (LADA), and to investigate changes in the expression of genes that regulate methylation as well as the autoimmune-related gene FOXP3 in these patients. Global CD4+ T cell DNA methylation was measured in 15 LADA patients and 11 healthy controls using a methylation quantification kit. mRNA levels of DNA methytransferases (DNMTs), methyl-DNA binding domain proteins (MBDs) and FOXP3 were measured by real time PCR. Methylation of a FOXP3 regulatory element region was determined by bisulphite genomic sequencing. Genomic DNA methylation in CD4+ T cells from LADA ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409177 Wed, 24 Aug 2011 04:00:00 +0100 5409177 http://www.medworm.com/index.php?rid=5477074&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004141%2Fabstract%3Frss%3Dyes Abstract: The benefits of self-monitoring of blood glucose (SMBG) in type 2 diabetes remain contentious. If SMBG data do not accurately reflect HbA1c, attempts to modify lifestyle/pharmacotherapy will be ineffective. We aimed to determine how well SMBG correlates with HbA1c and fasting serum glucose (FSG). Community-based type 2 patients using SMBG provided their highest and lowest pre- and post-prandial glucose results in the week before detailed assessment. The ability of average pre- and post-prandial SMBG to predict HbA1c>7.0% was determined by linear regression and receiver operating characteristic (ROC) analyses. Of 1286 patients with known SMBG status, 70% reported using SMBG. Pre-prandial SMBG data were obtained from 554 participants and post-prandial SMBG data from 418. The mean S... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5477074 Mon, 22 Aug 2011 04:00:00 +0100 5477074 http://www.medworm.com/index.php?rid=5409194&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004165%2Fabstract%3Frss%3Dyes Abstract: Proteasome modulator 9 (PSMD9) is linked to type 2 diabetes (T2D).The author studied whether PSMD9 IVS3+nt460 A>G, IVS3+nt437 T>C and E197 are linked to carpal tunnel syndrome in T2D Italian families.Non-parametric linkage, linkage disequilibrium-based and independent SNPs-based linkage analyses were performed. The PSMD9 SNPs show linkage to carpal tunnel syndrome. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409194 Mon, 22 Aug 2011 04:00:00 +0100 5409194 http://www.medworm.com/index.php?rid=5409193&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004098%2Fabstract%3Frss%3Dyes Abstract: In the present study we showed that the expression of transcription factor 7-like 2 (TCF7L2) mRNA in visceral adipose tissue obtained from 20 women with gestational diabetes was lower than in 18 pregnant women with normal glucose tolerance (p=0.02), however after adjusting for BMI values, the difference was not significant. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409193 Mon, 22 Aug 2011 04:00:00 +0100 5409193 http://www.medworm.com/index.php?rid=5409179&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100413X%2Fabstract%3Frss%3Dyes Conclusion: This study reveals that, even first-time diagnosis of T2DM, subjects with higher insulin resistance and abnormal lipids have elevated IL-12, endothelial dysfunction and proinflammatory markers. Further increased hsCRP enhance IL-12 which up-regulate cardiovascular disease progression. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409179 Mon, 22 Aug 2011 04:00:00 +0100 5409179 http://www.medworm.com/index.php?rid=5409172&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004074%2Fabstract%3Frss%3Dyes Conclusions: In this study of patients with type 2 diabetes, treatment with sitagliptin was associated with a significant decrease in serum ghrelin levels. These results suggest that the neutral effect of sitagliptin on weight might be associated with the suppression of fasting serum ghrelin levels. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409172 Mon, 22 Aug 2011 04:00:00 +0100 5409172 http://www.medworm.com/index.php?rid=5409171&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004062%2Fabstract%3Frss%3Dyes Abstract: Aim: To examine the relationship between early-onset type 2 diabetes (T2D) and retinopathy in relation to the burden, severity, the extent of its premature development and associated predictive risk factors.Methods: A cross sectional study using the hospital diabetes register and eye screening database to identify T2D subjects and to ascertain retinopathy severity. Early and later-onset cohort were defined as age of diagnosis 40 years respectively.Results: 2516 subjects were identified of which 455 were diagnosed below 40 years. After 10 years of diagnosis, the prevalence of overall retinopathy was significantly higher in the early-onset cohort (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409171 Mon, 22 Aug 2011 04:00:00 +0100 5409171 http://www.medworm.com/index.php?rid=5348463&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004050%2Fabstract%3Frss%3Dyes Conclusions: Serum SHBG levels were independently associated with the high-grade NAFLD in patients with type 2 diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348463 Mon, 22 Aug 2011 04:00:00 +0100 5348463 http://www.medworm.com/index.php?rid=5348461&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003664%2Fabstract%3Frss%3Dyes Conclusions: Hypertriglyceridaemia, present either as iHTG or HTWP was strongly associated with atherogenic dyslipidaemia. Dyslipidaemia occurred more frequently in glucose intolerance since the prevalence of both forms of hypertriglyceridaemia increased with glucose intolerance. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348461 Mon, 22 Aug 2011 04:00:00 +0100 5348461 http://www.medworm.com/index.php?rid=5348457&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271100355X%2Fabstract%3Frss%3Dyes Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348457 Mon, 22 Aug 2011 04:00:00 +0100 5348457 http://www.medworm.com/index.php?rid=5409191&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003962%2Fabstract%3Frss%3Dyes Abstract: We compared the intergenerational variations of the clinical phenotype between 30 patients affected with multiple autoimmune syndrome (MAS) and their affected first- and second-degree relatives. Mean age at onset was always significantly higher in the previous generation than in probands for all the considered diseases. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409191 Fri, 19 Aug 2011 04:00:00 +0100 5409191 http://www.medworm.com/index.php?rid=5409182&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003949%2Fabstract%3Frss%3Dyes Abstract: Aims: To evaluate the association between total dietary fiber and its types and sources with the risk of MetS.Methods: This population-based cross-sectional study was conducted on a representative sample of 2457 adults (1327 male and 1130 female), aged 19–84 years. Dietary intake was assessed using a validated semiquantitative food-frequency questionnaire. Anthropometrics, blood pressure, and fasting blood glucose and lipids were measured according to standard protocols. The MetS was defined according to definition by Adult Treatment Panel III.Results: Multivariate-adjusted odds ratio of MetS between highest and lowest quartiles was 0.53 (95% CI: 0.39–0.74; P for trend (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409182 Fri, 19 Aug 2011 04:00:00 +0100 5409182 http://www.medworm.com/index.php?rid=5226814&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003469%2Fabstract%3Frss%3Dyes The standardisation of HbA1c measurements has made considerable progress in the last years, which raised the question as to whether diabetes diagnosis should be based on glucose values or on the HbA1c . Recently an International Expert Committee recommended HbA1c as the preferred tool for diagnosing diabetes (≥6.5%), and in 2010 the ADA included an HbA1c ≥6.5% as an alternative criterion for the diagnosis of diabetes . The WHO has recently made a similar recommendation through an independent consultation . (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226814 Thu, 18 Aug 2011 04:00:00 +0100 5226814 http://www.medworm.com/index.php?rid=5409192&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004104%2Fabstract%3Frss%3Dyes Abstract: The proportion of sequential HbA1c exceeding critical difference (diagnostic yield), where it is considered clinically significant change, was calculated for different testing intervals. 12% and 26% of repeat HbA1c exceeded the critical difference before 30 and 90 days testing intervals, respectively. Repeating HbA1c within 4 weeks has poor diagnostic yield and should be avoided. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409192 Tue, 16 Aug 2011 04:00:00 +0100 5409192 http://www.medworm.com/index.php?rid=5409178&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004025%2Fabstract%3Frss%3Dyes Abstract: Aim of the study: To determine whether there is pathogenetic link between red cells sodium–lithium counter-transport activity and digoxin-like immunoreactive substances (DLIS) in plasma of insulin-dependent diabetic (IDDM) and non-diabetic women with preexisting preeclampsia (PE).Subjects and methods: We studied Na+/Li+ CT activity in red cells and plasma levels of DLIS in 11 IDDM women with preexisting PE (Group 1), 13 IDDM without preexisting PE (Group 2) 23 non-diabetic women with preexisting PE (Group 3) and 12 non-diabetic women with normal pregnancy (Group 4) at least 4 months after delivery.Results: Na+/Li+ CT activity was higher in Group 1 compared to Group 2 (mean±SEM 0.316±0.05 vs 0.190±0.02mmol/LRBC/hr p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409178 Tue, 16 Aug 2011 04:00:00 +0100 5409178 http://www.medworm.com/index.php?rid=5348472&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711004013%2Fabstract%3Frss%3Dyes Conclusion: The results indicate effectiveness in lowering A1c and acceptance by the patients. Further research and large-scale studies are needed. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348472 Tue, 16 Aug 2011 04:00:00 +0100 5348472 http://www.medworm.com/index.php?rid=5348470&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003597%2Fabstract%3Frss%3Dyes The 2nd Diabetic Foot Course, “Management of the Diabetic Foot”, was held in Pisa, Italy, 4–7 October 2010. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348470 Tue, 16 Aug 2011 04:00:00 +0100 5348470 http://www.medworm.com/index.php?rid=5409190&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003974%2Fabstract%3Frss%3Dyes We present a diabetic patient with acanthosis nigricans at the insulin injection site on the abdominal wall. Neglecting rotation of sites for insulin injections and local hyperinsulinemia may play a role in the development of acanthosis nigricans. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409190 Fri, 12 Aug 2011 04:00:00 +0100 5409190 http://www.medworm.com/index.php?rid=5409188&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003639%2Fabstract%3Frss%3Dyes Abstract: We evaluated the agreement between HbA1c- and FPG-based criteria for screening of diabetes in an asymptomatic Korean population and identified independent factors associated with discordance. The discordance between the two diabetic criteria was significantly associated with obesity and older age. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409188 Thu, 11 Aug 2011 04:00:00 +0100 5409188 http://www.medworm.com/index.php?rid=5409170&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003640%2Fabstract%3Frss%3Dyes Conclusion: Repaglinide is associated with improved postprandial glycaemic control via insulin and C-peptide release. We observed no direct effects of glibenclamide or repaglinide on plasma levels of GLP-1 or GIP. We observed no associations of GLP-1 and GIP with plasma markers of oxidative stress. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409170 Thu, 11 Aug 2011 04:00:00 +0100 5409170 http://www.medworm.com/index.php?rid=5409169&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003937%2Fabstract%3Frss%3Dyes Conclusions: These data suggest that the combination of age, BMI and systolic blood pressure could help identify Thai individuals at high risk of undiagnosed diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409169 Thu, 11 Aug 2011 04:00:00 +0100 5409169 http://www.medworm.com/index.php?rid=5409167&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003524%2Fabstract%3Frss%3Dyes This study aimed to examine the associations of cognitive function with hippocampal and whole brain atrophies, age, education, and diabetes-related parameters in patients with type 2 diabetes.Sixty-one patients over 65years of age with type 2 diabetes and 53 age- and sex-matched non-diabetic controls were enrolled. Hippocampal and whole brain atrophies were assessed by quantifying hippocampal and brain volumes by brain magnetic resonance imaging. Cognitive function was evaluated by Mini-Mental State Examination (MMSE) and the Revised Hasegawa Dementia Scale (HDS-R).Compared with the non-diabetic group, patients with type 2 diabetes showed significant increases in hippocampal and whole brain atrophies. The MMSE and HDS-R scores in type 2 diabetic patients showed significant negative correla... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409167 Thu, 11 Aug 2011 04:00:00 +0100 5409167 http://www.medworm.com/index.php?rid=5348471&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003585%2Fabstract%3Frss%3Dyes Abstract: The prevalence of Gestational Diabetes Mellitus (GDM) diagnosed by WHO criterion (2-hPG≥7.8mmol/L) was 13.4%. By International Association of Diabetes and Pregnancy Study Groups criteria of FPG≥5.1mmol/L, prevalence of GDM was 3.2%. FPG may not be suitable for diagnosis of GDM in Asian Indians due to high insulin resistance in addition to pregnancy hormonal effect. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348471 Thu, 11 Aug 2011 04:00:00 +0100 5348471 http://www.medworm.com/index.php?rid=5409189&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003986%2Fabstract%3Frss%3Dyes We examined trends and associated factors of disability among Spanish elderly with diabetes from data of three National Health Surveys (NHS) from 2000 to 2007. Prevalence of disability was higher among diabetic elderly versus non-sufferers and increased over time. Adjusted OR for activities of daily living 1.66 (1.37–2.00); instrumental activities of daily living 1.52 (1.31–1.77) and mobility disability 1.7 (1.45–1.98). (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409189 Wed, 10 Aug 2011 04:00:00 +0100 5409189 http://www.medworm.com/index.php?rid=5409174&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003627%2Fabstract%3Frss%3Dyes Abstract: Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia with various complications including diabetic hand syndrome (DHS); a condition characterized by association of distinct entities; limited joint mobility (LJM), Dupuytren's disease (DD), flexor tenosynovitis (FTS) and carpal tunnel syndrome (CTS) resulting in significant morbidity and mortality. The aim of this study was to evaluate the prevalence of these changes and their association to diabetes duration. We studied 142 type 2 and 45 type 1 DM patients and investigated the presence of these hand changes and peripheral neuropathy (PNP).The prevalence of LJM was 29.4%, DD was 17.6%, FTS was 10.7% and CTS 41.7% in all diabetics. The prevalence of CTS was more in type 2 DM (83.3%) as compared to type 1 DM (24... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409174 Wed, 10 Aug 2011 04:00:00 +0100 5409174 http://www.medworm.com/index.php?rid=5348458&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003615%2Fabstract%3Frss%3Dyes Conclusions: In current clinical practice, it is unlikely that there are considerable differences in risk of mortality associated with individual sulfonylureas in patients with heart failure. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348458 Wed, 10 Aug 2011 04:00:00 +0100 5348458 http://www.medworm.com/index.php?rid=5348462&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003652%2Fabstract%3Frss%3Dyes Conclusions: Age- and gender-adjusted HOMA-IR levels are reported in a representative Spanish adult non-diabetic population. There are gender-specific differences, with increased levels in women over fifty years of age that may be related with changes in body fat distribution after menopause. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348462 Mon, 08 Aug 2011 04:00:00 +0100 5348462 http://www.medworm.com/index.php?rid=5348460&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003676%2Fabstract%3Frss%3Dyes Abstract: Samples from 1295 patients with diabetic foot infection were evaluated; 4332 samples were collected with an average of 3.3 samples per patient. Fifty-seven percent of patients had a 2B ulcer and 23% had a 3B ulcer according to Texas University Classification. In 64.2% of samples collected at first visit an etiologic agent was identified. About 40% of the positive samples were polymicrobial. Gram positive bacteria were more frequently isolated (52.6%), Staphylococcus aureus was the most frequently isolated single agent (29.9%) and MRSA was 22% of S. aureus. Enterococcus spp., mainly Enterococcus faecalis, were 9.9%, all vancomycin susceptible except 2 isolates. Streptococci were 4.6%, more than 60% Streptococcus agalactiae. Gram negative rods were 40.6%, with enterobacteria 23.5% ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348460 Mon, 08 Aug 2011 04:00:00 +0100 5348460 http://www.medworm.com/index.php?rid=5226813&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003470%2Fabstract%3Frss%3Dyes Diagnosing diabetes is a common clinical challenge. Published in this issue of the journal is the report of the WHO consultation on the use of HbA1c for the diagnosis of diabetes which makes the following recommendation: (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226813 Mon, 08 Aug 2011 04:00:00 +0100 5226813 http://www.medworm.com/index.php?rid=5226811&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711001318%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226811 Mon, 08 Aug 2011 04:00:00 +0100 5226811 http://www.medworm.com/index.php?rid=5226832&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003603%2Fabstract%3Frss%3Dyes Non-communicable disease (NCD) represents a leading threat to health and human development . Diabetes mellitus (DM) is now considered to be one of the most common non-communicable diseases globally. It is the fourth/fifth leading cause of death in most high-income countries and there is substantial evidence that it is epidemic in many economically developing and newly industrialized nations . Complications from diabetes, such as coronary artery and peripheral vascular disease, stroke, diabetic neuropathy, amputations, renal failure and blindness are resulting in increasing disability, reduced life expectancy and enormous health costs for virtually every society . Diabetes is undoubtedly one of the world's most challenging health problems in the 21st century particularly for poor and rural ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226832 Fri, 05 Aug 2011 04:00:00 +0100 5226832 http://www.medworm.com/index.php?rid=5226831&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003512%2Fabstract%3Frss%3Dyes We examined associations of age at menarche and menstrual cycle characteristics with gestational diabetes mellitus (GDM) risk.Methods: Study participants (N=3490) recruited prior to 16 weeks of gestation were followed until delivery. Menstrual history data were collected using questionnaires. GDM was diagnosed using the American Diabetes Association 2003 guidelines. Logistic regression was used to estimate odds-ratios (OR) and 95% confidence intervals (CI).Results: Age at menarche was not associated with GDM risk. Women who had long menstrual cycles (>36 days) had higher risk of GDM compared with women who had normal cycle length (25–30 days) (OR=1.6; 95%CI0.98–2.67). Women who had long menstrual cycles and were either overweight or gained >5kg in adulthood had 4–5-fold higher GDM ri... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226831 Fri, 05 Aug 2011 04:00:00 +0100 5226831 http://www.medworm.com/index.php?rid=5409175&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003573%2Fabstract%3Frss%3Dyes Conclusions: Since coenzyme Q10 is believed to be an important cellular antioxidant defence, higher levels of CoQ10 in GDM patients may be a compensatory mechanism, in response to an activated oxidative stress, probably associated to hyperglycaemia and insulin resistance. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5409175 Thu, 04 Aug 2011 04:00:00 +0100 5409175 http://www.medworm.com/index.php?rid=5120224&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003688%2Fabstract%3Frss%3Dyes With just 25 days until the first ever UN High-Level Summit on Non-Communicable Diseases (NCDs), the global diabetes and NCD community are uniting around the priority issues that together represent the vision for success. On 23rd June the governments drafting the Outcomes Document for the Summit issued the first or ‘Zero draft’. That draft is the subject of intense negotiations by UN member states and all eyes are now trained on the negotiations in full swing in New York. The content and language in the Zero Draft has been picked over by analysts, and a real sense of urgency has grown among civil society as the deadline for negotiations looms ever closer. September and its much anticipated outcomes are now just around the corner. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5120224 Wed, 03 Aug 2011 23:00:00 +0100 5120224 http://www.medworm.com/index.php?rid=5348469&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003561%2Fabstract%3Frss%3Dyes Abstract: We investigated the risk factors for the development of diabetes mellitus, hypertension and dyslipidemia simultaneously in a community-based observational cohort study (n=4304). When hypertension or dyslipidemia was present at baseline, hazard ratio (95% CI) of developing diabetes mellitus at year 5 is 3.014 (2.131–4.264) or 2.112 (1.520–2.936), respectively. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348469 Mon, 01 Aug 2011 04:00:00 +0100 5348469 http://www.medworm.com/index.php?rid=5348459&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003548%2Fabstract%3Frss%3Dyes Conclusions: In the present study, the ApoB/ApoA1 ratio was significant to the 10-year incidence of diabetic retinopathy and to macular edema; and the TC/HDL ratio was significant to a 10-year incidence of macular edema. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348459 Mon, 01 Aug 2011 04:00:00 +0100 5348459 http://www.medworm.com/index.php?rid=5348445&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003536%2Fabstract%3Frss%3Dyes Conclusions: Folic acid supplementation lowered plasma level of homocysteine, improved glycemic control and insulin resistance in patients with type 2 diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348445 Mon, 01 Aug 2011 04:00:00 +0100 5348445 http://www.medworm.com/index.php?rid=5226812&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003482%2Fabstract%3Frss%3Dyes Diabetes is a common and serious condition which results in premature mortality, significant morbidity and has a considerable economic impact. A diagnosis of diabetes has important implications for the individual. It not only commits them to a lifetime of treatment but also may affect work opportunities and social interactions, underlining the importance of making a correct diagnosis. While relatively easy to diagnose in people who are symptomatic, the diagnosis of diabetes may be challenging in an asymptomatic individual. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5226812 Fri, 29 Jul 2011 04:00:00 +0100 5226812 http://www.medworm.com/index.php?rid=5348468&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822711003445%2Fabstract%3Frss%3Dyes Abstract: Glycated albumin (GA) is a new glycemic control indicator. GA/HbA1c ratio in autoimmune acute-onset type 1 diabetes mellitus patients was significantly higher than in type 2 diabetes mellitus patients at the time of diagnosis. This difference might reflect speed of increase in plasma glucose after the onset of diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=5348468 Fri, 22 Jul 2011 04:00:00 +0100 5348468