MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diabetes Research and Clinical Practice' source. Sat, 13 Mar 2010 14:17:37 +0100 http://www.medworm.com/index.php?rid=3348014&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882271000094X%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348014 Wed, 10 Mar 2010 15:07:11 +0100 3348014 http://www.medworm.com/index.php?rid=3344111&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000501%2Fabstract%3Frss%3Dyes As the world watches Haiti grapple with the traumatic impact of the recent earthquake, many wonder how the island nation will rebuild itself and how its citizens will get the help they need. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344111 Wed, 24 Feb 2010 00:00:00 +0100 3344111 http://www.medworm.com/index.php?rid=3344093&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000471%2Fabstract%3Frss%3Dyes Conclusion: The coexistence of diabetes and depression is associated with significant morbidity, mortality, and increased healthcare cost. Coordinated strategies for clinical care are necessary to improve clinical outcomes and reduce the burden of illness. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344093 Wed, 24 Feb 2010 00:00:00 +0100 3344093 http://www.medworm.com/index.php?rid=3344092&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000495%2Fabstract%3Frss%3Dyes Conclusions: Diabetes imposes an increasing economic burden on national health care systems worldwide. More prevention efforts are needed to reduce this burden. Meanwhile, the very low expenditures per capita in poor countries indicate that more resources are required to provide basic diabetes care in such settings. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344092 Mon, 22 Feb 2010 00:00:00 +0100 3344092 http://www.medworm.com/index.php?rid=3348016&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900549X%2Fabstract%3Frss%3Dyes Conclusions: Despite the high difference in health per capita investment and system characteristics among countries, the study populations had striking similarities regarding the low percentage of participants who achieved cardiovascular risk factor and diabetes treatment goals. Therefore, differences in health budget and system characteristics would not be the main drivers in care quality. Diabetes education at every level and quality care registries would contribute to improve this situation and assess such improvement. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348016 Mon, 15 Feb 2010 00:00:00 +0100 3348016 http://www.medworm.com/index.php?rid=3348035&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000288%2Fabstract%3Frss%3Dyes In this study, titanium implants were placed in the femora of 10 type 2 diabetic and 10 age-matched normal rats. We compared the results of bone histomorphometry around the dental implants at 4 and 8 weeks postsurgery. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348035 Mon, 08 Feb 2010 00:00:00 +0100 3348035 http://www.medworm.com/index.php?rid=3344110&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000173%2Fabstract%3Frss%3Dyes October 2009 saw the arrival of the global diabetes community in Montreal, Canada, for the 20th World Diabetes Congress. Nearly 18 months earlier I participated in the 2nd Elsevier/OCDEM Junior Research Competition, an event for DPhil students and junior researchers at the Oxford Centre for Diabetes, Endocrinology and Metabolism. Having recently completed my DPhil studies I submitted an abstract outlining the key findings from my thesis entitled “Pancreatic fat accumulation and effects on beta cell function”. Five abstracts, including mine, were selected for oral presentations which we delivered to a panel of judges and an audience of OCDEM researchers. To my surprise the judges selected my presentation and as the recipient of the Elsevier/OCDEM Junior Research Prize 2008, Elsevier kin... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344110 Mon, 08 Feb 2010 00:00:00 +0100 3344110 http://www.medworm.com/index.php?rid=3348019&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000161%2Fabstract%3Frss%3Dyes Conclusions: Serum omentin-1 levels were decreased in impaired glucose regulation subjects. Lack of omentin-1 may contribute to the development of insulin resistance and T2DM. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348019 Wed, 03 Feb 2010 00:00:00 +0100 3348019 http://www.medworm.com/index.php?rid=3348034&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000070%2Fabstract%3Frss%3Dyes Abstract: A 61-year-old woman with fasting hypoglycemia following total gastrectomy was diagnosed as insulinoma. GIP and GLP-1 levels after a mixed meal were extremely increased. Administration of miglitol, an alpha-glucosidase inhibitor, suppressed the GIP and GLP-1 elevations. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348034 Mon, 01 Feb 2010 00:00:00 +0100 3348034 http://www.medworm.com/index.php?rid=3348033&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000124%2Fabstract%3Frss%3Dyes Abstract: The aim of this study was to establish a cut-off value of percentage of fat mass (%FM) at which insulin sensitivity (IS) is significantly altered in sedentary postmenopausal women. Our results suggest that maintaining a %FM below 41% would minimize the deterioration of IS and its associated risks. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348033 Mon, 01 Feb 2010 00:00:00 +0100 3348033 http://www.medworm.com/index.php?rid=3348015&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005518%2Fabstract%3Frss%3Dyes Abstract: We conducted a meta-analysis of studies reporting diabetes case management interventions to examine the impact of case management on blood glucose control (HbA1c). Databases used for the search included Medline, PubMed, Cochrane EPOC, Cumulative Index to Nursing & Allied Health Literature database guide (CINAHL), and PsychInfo. A composite estimate of effect size was calculated using a random effects model and subgroup analyses were conducted. Twenty-nine salient studies involving 9397 patients had sufficient data for analysis. Mean patient age was 63.2 years, 49% were male, and ethnicity/race was 54% White. Type 2 diabetes was the focus in 91% of studies. Results showed a large overall effect size favoring case management intervention over controls or baseline values on HbA1c (E... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348015 Mon, 01 Feb 2010 00:00:00 +0100 3348015 http://www.medworm.com/index.php?rid=3206165&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004860%2Fabstract%3Frss%3Dyes Abstract: Objective: To study the relationship of newborn size and post-natal growth to glucose intolerance in south Indian adults.Research design and methods: 2218 men and women (mean age 28 years) were studied from a population-based birth cohort born in a large town and adjacent rural villages. The prevalence of adult diabetes mellitus [DM] and impaired glucose tolerance [IGT], and insulin resistance and insulin secretion (calculated) were examined in relation to BMI and height at birth, and in infancy, childhood and adolescence and changes in BMI and height between these stages.Results: Sixty-two (2.8%) subjects had Type 2 diabetes (DM) and 362 (16.3%) had impaired glucose tolerance (IGT). IGT and DM combined (IGT/DM) and insulin resistance were associated with low childhood body mass ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206165 Tue, 26 Jan 2010 14:17:06 +0100 3206165 http://www.medworm.com/index.php?rid=3206142&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000410%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206142 Tue, 26 Jan 2010 14:17:02 +0100 3206142 http://www.medworm.com/index.php?rid=3344097&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000057%2Fabstract%3Frss%3Dyes Abstract: Circulating matrix metalloproteinase (MMP) levels may correlate with diabetic complications. Whether they are changed in early diabetic cardiomyopathy is not known and was examined in this study. TIMP-1 and collagen degradation products were also measured. Results from subjects with and without diastolic dysfunction were compared with those obtained for patients with varying stages of diabetic renal disease.Patients with type 2 diabetes with or without diastolic dysfunction with varying degrees of renal disease were recruited for this study. Age-matched non-diabetic subjects served as controls. MMPs (-1, -3 and -7) and TIMP-1 were measured by ELISA, MMP-2 and -9 by zymography and collagen degradation products by radioimmunoassay.Differences in the pattern of MMPs/TIMPs and collag... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344097 Mon, 25 Jan 2010 00:00:00 +0100 3344097 http://www.medworm.com/index.php?rid=3348032&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005506%2Fabstract%3Frss%3Dyes Abstract: Aims: Comparing waist circumference (WC) role in diabetes risk prediction and diagnosis of metabolic syndrome (MS) in different populations.Methods: Population-based samples from Australia (n=9026) and Iran (n=8259) were studied in 2000 and followed for ∼4 years. Follow-up attendance was ∼58% and mean age was 51 vs. 47. Pearson correlations calculated between WC and other MS components. ROC for the role of WC in the prediction of incident diabetes was used.Results: Prevalences of MS (48% vs. 28%), an increased WC (58.5% vs. 54.5%), low HDL-C (35% vs. 11.2%), high triglyceride (52.2% vs. 29.6%) were significantly higher in Iran. Fasting glucose ≥5.6mmol/L was higher in Australia (26% vs. 23%). Hypertension was no different (∼38%). Pearson correlations between WC and other ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348032 Fri, 22 Jan 2010 00:00:00 +0100 3348032 http://www.medworm.com/index.php?rid=3348031&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000045%2Fabstract%3Frss%3Dyes Abstract: Objective: To investigate whether alanine aminotransferase (ALT), even within the reference range, is associated with atherosclerotic burden in apparently healthy adults.Methods: This was an observational study performed on 830 healthy individuals with normal ALT concentration (≤40U/L). Atherosclerotic burden was assessed by carotid arterial intima-media thickness (IMT). All subjects were divided according to the quartile based on their ALT concentrations.Results: Despite all subjects having a normal ALT concentration, ultrasonographic liver steatosis was observed in 48.4% and 36.7% of men and women, respectively. In both genders, subjects in the highest quartile of ALT concentration had a significantly higher waist circumference, triglyceride concentration, HOMA-IR, a higher p... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348031 Fri, 22 Jan 2010 00:00:00 +0100 3348031 http://www.medworm.com/index.php?rid=3348017&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000094%2Fabstract%3Frss%3Dyes Abstract: Juvenile metabolic syndrome (MetS) is a growing major medical problem in industrialised countries. We estimated its prevalence among two similar clinic-based sequentially recruited cohorts of extremely obese adolescents (age: 12–18 years) from Italy (N=665, males=271, females=394) and Germany (N=661, males=261, females=400) using the recent IDF paediatric criteria. The prevalence of the MetS was 23.3% among the Italians and 40.4% among the Germans. A multivariate logistic regression revealed an increased risk related to age (adjusted odd ratio (AOR): 2.24; 95% confidence interval (CI): 1.59–3.16; p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348017 Fri, 22 Jan 2010 00:00:00 +0100 3348017 http://www.medworm.com/index.php?rid=3344095&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005452%2Fabstract%3Frss%3Dyes Conclusions: Neither a GLP-1 agonist nor a DPP-4 inhibitor, at doses that do not alter blood glucose levels, prevented the inhibition of insulin gene expression in this in vivo model of glucolipotoxicity. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344095 Fri, 22 Jan 2010 00:00:00 +0100 3344095 http://www.medworm.com/index.php?rid=3348028&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000033%2Fabstract%3Frss%3Dyes This study included 464 subjects: 269 patients with T2D and 195 healthy controls in South Korea. We genotyped subjects for four single nucleotide polymorphisms (SNPs): ENPP1 K121Q, ENPP1 A/G+1044TGA, MMP3 −709A>G and MMP3 −1475G>A. The presence or absence of calcifications in the aortic arch was assessed by plain chest radiography.Results: The SNPs ENPP1 K121Q and MMP3 −709A>G showed significant associations with T2D (P=0.001 and P=0.004). The SNP ENPP1 K121Q showed a significant association with aortic arch calcification in T2D (P=0.036). Serum OPG levels were significantly higher in T2D patients than in the control group (P (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348028 Thu, 21 Jan 2010 00:00:00 +0100 3348028 http://www.medworm.com/index.php?rid=3348030&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005476%2Fabstract%3Frss%3Dyes Conclusions: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348030 Mon, 18 Jan 2010 00:00:00 +0100 3348030 http://www.medworm.com/index.php?rid=3348029&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000021%2Fabstract%3Frss%3Dyes Conclusion: In patients with STEMI treated with primary PCI, hyperglycemia on admission is associated with larger infarct size determined by SPECT. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348029 Mon, 18 Jan 2010 00:00:00 +0100 3348029 http://www.medworm.com/index.php?rid=3348022&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005403%2Fabstract%3Frss%3Dyes This study indicates that SC CDEs do not routinely provide comprehensive oral health education to people with diabetes primarily due to lack of time and knowledge related to oral health. To better serve their patients, CDEs should integrate oral health education in the diabetes education curriculum. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348022 Fri, 15 Jan 2010 00:00:00 +0100 3348022 http://www.medworm.com/index.php?rid=3348018&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822710000082%2Fabstract%3Frss%3Dyes Conclusions: Hypoglycemia associated EEG changes could be detected by an automated mathematical algorithm in all subjects exposed to insulin-induced hypoglycemia. In 12 of 15 patients, EEG changes occurred before severe hypoglycemia as evaluated by the cognitive testing. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348018 Fri, 15 Jan 2010 00:00:00 +0100 3348018 http://www.medworm.com/index.php?rid=3348020&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005439%2Fabstract%3Frss%3Dyes Conclusion: This study suggests that vigorous PA may affect IF reductions in obese men. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348020 Thu, 14 Jan 2010 00:00:00 +0100 3348020 http://www.medworm.com/index.php?rid=3348027&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005488%2Fabstract%3Frss%3Dyes Abstract: Aim: To determine the possible factors predicting the insulin requirement in pregnancies complicated by gestational diabetes mellitus (GDM).Method: A total of 294 patients with GDM diagnosed by the 100-g/3-h oral glucose tolerance test (OGTT) were studied. The following factors were analyzed: maternal age, nulliparity, family history of diabetes, prepregnancy BMI, prior GDM, prior fetal macrosomia, multiple pregnancy, polyhydramnios, gestational age at diagnosis of GDM, smoking, hypertension, number of abnormal 100-g/3-h OGTT values, and glycated hemoglobin (HbA1c). The association between each factor and the need for insulin therapy was then analyzed individually. The performance of these factors to predict the probability of insulin therapy was estimated using a logistic regres... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348027 Wed, 13 Jan 2010 00:00:00 +0100 3348027 http://www.medworm.com/index.php?rid=3344109&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005385%2Fabstract%3Frss%3Dyes Conclusions: Because many people, especially older non-Hispanic blacks, with HbA1c levels of 6.5–6.9% would not have diabetes by current FPG/OGTT criteria and clinical retinopathy and nephropathy are very unusual in patients whose HbA1c levels are kept (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344109 Mon, 11 Jan 2010 00:00:00 +0100 3344109 http://www.medworm.com/index.php?rid=3348021&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005427%2Fabstract%3Frss%3Dyes Abstract: Aim: To compare effects of three different insulin secretagogues on early-phase insulin secretion, metabolism of glucose and lipids, and lipid peroxidation in newly diagnosed Type 2 Diabetes Mellitus (T2DM).Methods: Totally 60 newly diagnosed T2DM outpatients were randomized to three groups with 1-month monotherapy of repaglinide (Rg), glimepiride (Gm) or gliclazide MR (Gli), respectively. Some indexes of early-phase insulin secretion, glucose, lipids, and lipid peroxidation were inspected.Results: Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and fructosamine (FA) were improved in all groups similarly (p>0.05). Rg group was with the highest early-phase insulin secretion index (ΔI30/ΔG30) (p=0.026), lower mean amplitude of glycaemic excursion (MAGE) (p (Source: ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348021 Fri, 08 Jan 2010 00:00:00 +0100 3348021 http://www.medworm.com/index.php?rid=3344108&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005397%2Fabstract%3Frss%3Dyes Abstract: Aims: To determine the prevalence of inadequate glycemic control and its correlates in a large multicenter survey of Venezuelan patients with diabetes.Methods: A cross-sectional study in a sample of adult patients with diabetes, attending health centers in Venezuela. Information about diabetes, current medications, complications, and diet were obtained by trained interviewers, using a standardized questionnaire. HbA1c was measured by high-performance liquid chromatography in a central laboratory. Patients with HbA1c≥7% were considered to have inadequate glycemic control.Results: Overall 4075 patients were surveyed, 349(8.6%) with type 1 diabetes (T1D) and 3726(91.4%) with type 2 diabetes(T2D). Subjects’ mean age was 58 years, and 65% were female. The prevalence of inadequate ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344108 Fri, 08 Jan 2010 00:00:00 +0100 3344108 http://www.medworm.com/index.php?rid=3344096&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005464%2Fabstract%3Frss%3Dyes Conclusions: Mosapride is effective in decreasing FPG without stimulating insulin secretion in IGT subjects, possibly by inducing GLUT4 translocation in skeletal muscles. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344096 Fri, 08 Jan 2010 00:00:00 +0100 3344096 http://www.medworm.com/index.php?rid=3348026&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005440%2Fabstract%3Frss%3Dyes Abstract: Background: The polymorphism 385 C/A of FAAH has been associated with overweight and obesity. The aim of our study was to investigate the relationship of polymorphism (cDNA 385 C→A) of FAAH gene on obesity parameters in patients with diabetes mellitus type 2.Design: A population of 70 patients with diabetes mellitus type 2 was analyzed. An anthropometric and biochemical nutritional assessment was performed. The statistical analysis was performed for the combined C358A and A358A as a group and wild type C358C as second group.Results: Fifty-five patients (78.7%) had genotype C358C (wild type group) and 15 (21.3%) patients C358A (14 patients, 20.6%) or A358A (1 patient, 0.7%) (mutant group). BMI (38.9±6.4 vs. 39.2±5.7, p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348026 Thu, 07 Jan 2010 00:00:00 +0100 3348026 http://www.medworm.com/index.php?rid=3344115&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005415%2Fabstract%3Frss%3Dyes Abstract: Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were confined to islets in human pancreas. This suggests neuropilins-1 could influence the development of some cases of T1D in children. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344115 Wed, 06 Jan 2010 00:00:00 +0100 3344115 http://www.medworm.com/index.php?rid=3348025&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900535X%2Fabstract%3Frss%3Dyes Conclusions: Glimepiride can rapidly and stably improve glycemic control and lipoprotein metabolism, significantly alleviate insulin resistance and enhance fibrinolytic activity. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348025 Mon, 04 Jan 2010 00:00:00 +0100 3348025 http://www.medworm.com/index.php?rid=3348024&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005361%2Fabstract%3Frss%3Dyes We examined whether glycated hemoglobin (HbA1C) levels of Japanese diabetic patients showed seasonal fluctuations.Methods: Subjects included 2511 diabetic patients who regularly visited a single diabetic outpatient clinic for 10 years. A total of 253,477 HbA1C measurements, as well as sex, age, BMI, type of diabetes, and mode of therapy were extracted from a hospital-based database. For the cross-sectional and longitudinal analyses, average monthly HbA1C values of subjects and amplitudes of seasonal fluctuations were calculated. For the time-series analysis, seasonal adjustment factors of each subject were classified as complete, incomplete, or no fluctuation.Results: Subjects showed a clear seasonal fluctuation of HbA1C levels, with highest levels in March (7.69%) and lowest levels in Aug... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348024 Mon, 04 Jan 2010 00:00:00 +0100 3348024 http://www.medworm.com/index.php?rid=3348023&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005373%2Fabstract%3Frss%3Dyes Conclusions: A multifaceted program merging standard interventions in support of general practice induced significant improvements in the quality of diabetes care. Intensified follow-up in AQIP with focus on shared care and patient behaviour changes did not yield additional benefit. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3348023 Mon, 04 Jan 2010 00:00:00 +0100 3348023 http://www.medworm.com/index.php?rid=3344114&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005336%2Fabstract%3Frss%3Dyes Abstract: SP1 mRNA was highly expressed in the epiretinal membranes of proliferative diabetic retinopathy (PDR), and the SP1 protein was mainly co-localized with vascular endothelial growth factor. SP1 might play an important role in the angiogenesis of PDR by regulating the promoter activity and expression of genes encoding angiogenesis-related factors. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344114 Mon, 04 Jan 2010 00:00:00 +0100 3344114 http://www.medworm.com/index.php?rid=3344103&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004951%2Fabstract%3Frss%3Dyes We examined 3940 patients with manifest arterial disease, hypertension or hyperlipidemia, aged 55.2±12.2 years. Leisure-time physical activity was measured by a questionnaire and metabolic equivalent (MET) hours per week (h/wk) were calculated. Incident T2DM was evaluated by a specific diabetes questionnaire.Results: Most patients (65%) were physically inactive (0METh/wk), 12% were insufficiently physically active (0–10.5METh/wk) and 23% were sufficiently physically active (≥10.5METh/wk). During a mean follow-up of 4.7 years, 194 (5%) incident cases of T2DM occurred. Sufficiently physically active patients had a lower incidence of diabetes (hazard ratio (HR) 0.55, 95% confidence interval (CI) 0.37–0.83). Patients who were physically active and not-obese (BMI (Source: Diabetes Resear... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344103 Mon, 04 Jan 2010 00:00:00 +0100 3344103 http://www.medworm.com/index.php?rid=3344101&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004926%2Fabstract%3Frss%3Dyes Abstract: Aims: The number of prescription medications and out-of-pocket expenses of individuals with type 2 diabetes mellitus (T2DM) were evaluated to assess the economic burden of diabetes.Methods: The self-reported number of prescription medications and out-of-pocket healthcare expenses were evaluated from respondents of the United States SHIELD study with and without a diagnosis of T2DM. Medications included monotherapy and combination therapy; combination tablets were counted as one agent. Analysis of variance and multivariate linear regression models adjusted for age, gender, prescription insurance coverage, and household income.Results: Of the T2DM respondents (n=3551), 40% were on 1 prescription antidiabetic agent (7% insulin alone), 26% were on 2 agents, 8% were on ≥3 agents, wi... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344101 Mon, 04 Jan 2010 00:00:00 +0100 3344101 http://www.medworm.com/index.php?rid=3173533&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005038%2Fabstract%3Frss%3Dyes As I write this, a battle is being waged in the outside world. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173533 Mon, 04 Jan 2010 00:00:00 +0100 3173533 http://www.medworm.com/index.php?rid=3173534&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005312%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173534 Fri, 01 Jan 2010 00:00:00 +0100 3173534 http://www.medworm.com/index.php?rid=3173512&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709005300%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173512 Fri, 01 Jan 2010 00:00:00 +0100 3173512 http://www.medworm.com/index.php?rid=3206168&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004963%2Fabstract%3Frss%3Dyes Abstract: To evaluate the feasibility of a Telemedicine system based on Internet and short message service in the follow-up of patients with gestational diabetes. Compared to control group, Telemedicine group reduced 62% the number of unscheduled face-to-face visits, and 82.7% in the subgroup of insulin-treated patients, improving patient satisfaction, and achieving similar pregnancy and new born outcomes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206168 Thu, 31 Dec 2009 00:00:00 +0100 3206168 http://www.medworm.com/index.php?rid=3206167&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004975%2Fabstract%3Frss%3Dyes Abstract: As part of our evaluation of the Diabetes UK Careline workshop “Overcoming barriers to diabetes care”, we received feedback from 18 healthcare professionals. Generally, they felt competent in identifying patients’ psychosocial issues but less knowledgeable/skilled in handling them. Lack of time, privacy and support were barriers to addressing patients’ psychosocial concerns. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206167 Thu, 31 Dec 2009 00:00:00 +0100 3206167 http://www.medworm.com/index.php?rid=3206153&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900494X%2Fabstract%3Frss%3Dyes Abstract: Aims: The study's aim was to quantify prevalence of tolerability issues among patients with T2DM currently treated with OADs and to assess its association with treatment adherence, satisfaction and health-related quality of life (HRQL).Methods: Data were collected from the 2006–2008 US National Health and Wellness Survey and the Ailment Panel of Lightspeed Online Research, an internet-based questionnaire. Participants (N=2074) self-reported a diagnosis of T2DM, were >18 years of age and currently taking >1 OADs but not insulin, and spoke English.Results: The majority (71.7%) experienced at least 1 tolerability issue in the past 2 weeks; 49.7% experienced >2. Tolerability issues included signs/symptoms of hypoglycemia (57.2%), constipation/diarrhea (28%), headaches (25.6%), weig... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206153 Mon, 28 Dec 2009 00:00:00 +0100 3206153 http://www.medworm.com/index.php?rid=3344112&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004999%2Fabstract%3Frss%3Dyes Abstract: Our studies suggest that plasma soluble advanced glycation end products (sRAGEs) has significantly negative association with high sensitivity C-reactive protein (hs-CRP) in 245 type 2 diabetes patients without diagnosed coronary artery disease (CAD). sRAGE maybe act as a novel biomarker for predicting the atherosclerosis in diabetes at the early stage. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344112 Fri, 25 Dec 2009 00:00:00 +0100 3344112 http://www.medworm.com/index.php?rid=3344107&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004987%2Fabstract%3Frss%3Dyes Conclusions: BMI was not a good discriminator of cardio-metabolic risk factors in Australian Indigenous populations compared with other anthropometric indices. WHpR is more closely associated with the risk of cardio-metabolic in these high-risk populations. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344107 Fri, 25 Dec 2009 00:00:00 +0100 3344107 http://www.medworm.com/index.php?rid=3344102&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004914%2Fabstract%3Frss%3Dyes Abstract: Aims: To develop a prediction algorithm to rule out diabetic ketoacidosis (DKA) and non-ketotic hyperosmolar syndrome (NKHS) based on vital signs for early triage of patients with diabetes.Methods: The subjects were consecutive adult diabetic patients with hyperglycemia (blood glucose ≥250mg/dl) who presented at an emergency department. Based on a derivation sample (n=392, 70% of 544 patients at a hospital in Okinawa), recursive partitioning analysis was used to develop a tree-based algorithm. Validation was conducted using the other 30% of the patients in Okinawa (n=152, internal validation) and patients at a hospital in Tokyo (n=95, external validation).Results: Three risk groups for DKA/NKHS were identified: a high-risk group of patients with glucose >400mg/dl or systolic bl... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344102 Mon, 21 Dec 2009 00:00:00 +0100 3344102 http://www.medworm.com/index.php?rid=3344099&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004859%2Fabstract%3Frss%3Dyes Conclusions: The study findings suggest that commonly accessible statistics, such as correlation statistics, offer estimates that are comparable to complicated approaches. Different time lags were observed with two CGM systems. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344099 Mon, 21 Dec 2009 00:00:00 +0100 3344099 http://www.medworm.com/index.php?rid=3344094&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004896%2Fabstract%3Frss%3Dyes Abstract: Diabetes mellitus is characterized by chronic hyperglycaemia and a significant risk of developing micro- and macrovascular complications. Growing evidence suggests that increased oxidative stress, induced by several hyperglycaemia-activated pathways, is a key factor in the pathogenesis of endothelial dysfunction and vascular disease.Reactive oxidant molecules, which are produced at a high rate in the diabetic milieu, can cause oxidative damage of many cellular components and activate several pathways linked with inflammation and apoptosis. Among the mechanisms involved in oxidative stress generation, mitochondria and uncoupling proteins are of particular interest and there is growing evidence suggesting their pivotal role in the pathogenesis of diabetic complications. Other impor... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344094 Mon, 21 Dec 2009 00:00:00 +0100 3344094 http://www.medworm.com/index.php?rid=3206166&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900480X%2Fabstract%3Frss%3Dyes We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5′-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206166 Mon, 21 Dec 2009 00:00:00 +0100 3206166 http://www.medworm.com/index.php?rid=3206164&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004872%2Fabstract%3Frss%3Dyes Conclusions: While several factors may explain the increase in type 2 DM-related LEAs, these findings highlight the importance of diabetes prevention strategies and controlling risk factors for LEAs in people with diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206164 Mon, 21 Dec 2009 00:00:00 +0100 3206164 http://www.medworm.com/index.php?rid=3206163&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004823%2Fabstract%3Frss%3Dyes Conclusions: The STOP-NIDDM risk-score is a simple and validated tool that can identify high-risk individuals with IGT who would benefit most from type 2 diabetes or CVD prevention strategies, such as lifestyle management or early acarbose treatment. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206163 Mon, 21 Dec 2009 00:00:00 +0100 3206163 http://www.medworm.com/index.php?rid=3206152&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004884%2Fabstract%3Frss%3Dyes Abstract: Background: Endomorphins are endogenous ligands selective for μ-opioid receptors, which have been reported to stimulate appetite and regulate glucose homeostasis. But there are no reports about changes in peripheral endomorphin-1 (EM-1) levels in diabetic patients. The aim of this study was to measure plasma EM-1 levels in fasting and postprandial conditions in diabetic patients.Methods: After an overnight fast, 38 patients (mean age, 67±8 years; 17 males and 21 females) and 22 healthy volunteers (mean age, 64±9 years; 9 males and 13 females) received a standard breakfast meal with total energy content of 476.1kcal. Blood samples were drawn from each subject in heparinized tubes before breakfast and 2h postprandially. Plasma concentrations of EM-1 were measured by radioimmunoa... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206152 Mon, 21 Dec 2009 00:00:00 +0100 3206152 http://www.medworm.com/index.php?rid=3344104&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004902%2Fabstract%3Frss%3Dyes Abstract: Aim: To investigate the relationships of serum fatty acid (FA) composition and estimated desaturase activities with the liver fat marker alanine aminotransferase (ALT).Methods: 546 Swedish elderly men of a population-based cohort participated in this cross-sectional study. FA composition was assessed in serum cholesterol esters to determine dietary fat quality (e.g. linoleic) and desaturation products (e.g. dihomo-γ-linolenic acid). Desaturase indices, including stearoyl coenzymeA desaturase-1 (SCD-1), were calculated by FA product-to-precursor ratios.Results: In linear regression analyses adjusting for lifestyle, abdominal obesity and insulin sensitivity, the dietary biomarker linoleic acid (n-6), but not n-3 FAs, was inversely related to ALT. Desaturation products including pa... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344104 Fri, 18 Dec 2009 00:00:00 +0100 3344104 http://www.medworm.com/index.php?rid=3344113&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004847%2Fabstract%3Frss%3Dyes We report a case of MODY2 caused by a novel GCK mutation and demonstrate differential glycemic/C-peptide responses to treatment with insulin, no medication, and an oral sulfonylurea. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344113 Wed, 16 Dec 2009 00:00:00 +0100 3344113 http://www.medworm.com/index.php?rid=3344100&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004835%2Fabstract%3Frss%3Dyes In this study, we determined that the absence of DR, a lower fasting blood glucose level, and IMT is useful in differentiating NDRD from DN in diabetic patients with overt proteinuria. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344100 Mon, 14 Dec 2009 00:00:00 +0100 3344100 http://www.medworm.com/index.php?rid=3206151&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004781%2Fabstract%3Frss%3Dyes Abstract: Objective: To describe relationships of retinal vascular calibre with plasminogen activator inhibitor-1 (PAI-1) and other cardiovascular risk factors in people with type 2 diabetes.Methods: We recruited 112 community-based persons aged 44–83years with type 2 diabetes, photo-documented retinal status using a digital fundus camera, and measured traditional and novel vascular risk factors. Retinal arteriolar and venular calibre and the arterio–venous ratio (AVR) were determined from fundus photographs using a validated computer-assisted method.Results: In adjusted linear regression models, PAI-1 activity was strongly associated with all measures of retinal vascular calibre: positively with arterioles (p=0.005) and AVR (p=0.001), and inversely with venules (p=0.001). In addition,... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206151 Mon, 14 Dec 2009 00:00:00 +0100 3206151 http://www.medworm.com/index.php?rid=3173536&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004756%2Fabstract%3Frss%3Dyes Abstract: We conducted a survey to know the prevalence of diabetes and obesity in young-adult (20–40 years) men and non-pregnant-women in Kashmir Valley (India); prevalence of latter is presented here. The age-adjusted prevalence of overweight–obesity was 16.3% and that of obesity 5.1%; the relationship of overweight–obesity with glucose intolerance is discussed. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173536 Mon, 14 Dec 2009 00:00:00 +0100 3173536 http://www.medworm.com/index.php?rid=3344098&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004811%2Fabstract%3Frss%3Dyes Conclusions: In Iranian population, MetS did not add to diabetes to predict incident CVD however, IFG/IGT was a significant predictor only in the presence of MetS. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344098 Wed, 09 Dec 2009 00:00:00 +0100 3344098 http://www.medworm.com/index.php?rid=3206162&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004744%2Fabstract%3Frss%3Dyes This study aimed to test whether hypomagnesaemia is present in pre-diabetes, obesity and the metabolic syndrome.Methods: 1453 adults from randomly selected households from rural Victoria, Australia, attended for biomedical assessment. Serum magnesium concentrations, hypomagnesaemia defined using local laboratory criteria ( (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206162 Wed, 09 Dec 2009 00:00:00 +0100 3206162 http://www.medworm.com/index.php?rid=3173517&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900429X%2Fabstract%3Frss%3Dyes Conclusions: The Kathmandu Declaration presents the concept of a “Life Circle” approach to prevention and care of diabetes—a continuum beginning from preconception, pregnancy, infancy and childhood to adult life in an integrated manner. Emphasis is on the benefits on entering the circle at any point and formulates guidelines that could be incorporated in any national diabetes prevention and care programme, indicating the interactive role of all known aetiological factors. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173517 Wed, 09 Dec 2009 00:00:00 +0100 3173517 http://www.medworm.com/index.php?rid=3206150&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004793%2Fabstract%3Frss%3Dyes Conclusion: These data indicate an important participation of the cholinergic nervous system through muscaric receptors in dexamethasone-induced hyperinsulinemia in rats. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206150 Mon, 07 Dec 2009 00:00:00 +0100 3206150 http://www.medworm.com/index.php?rid=3206148&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004707%2Fabstract%3Frss%3Dyes Conclusion: In conclusion, podocyte damage occurred in patients with DN, even in the early stage and became more dramatic during the course of proteinuria progression. WT1 staining, using the polyclonal antibody to stain the nuclei and monoclonal antibody to stain the cytoplasma of podocytes together, is a valuable alternative technique in the study of podocyte injury. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206148 Mon, 07 Dec 2009 00:00:00 +0100 3206148 http://www.medworm.com/index.php?rid=3173514&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900477X%2Fabstract%3Frss%3Dyes In December 2006 the United Nations unanimously adopted resolution 61/225, recognising that diabetes poses a threat to human well being throughout the world and challenges the achievement of economic and social development goals in low and middle-income countries. The resolution calls upon all countries to develop national policies for the prevention, care, and treatment of diabetes. The key aim of the IDF Diabetes Atlas is to promote and support these efforts. It does this by providing authoritative, timely and highly accessible information on the burden of diabetes, what is known about how to prevent it and its complications, and what needs to be done to translate this knowledge into action. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173514 Mon, 07 Dec 2009 00:00:00 +0100 3173514 http://www.medworm.com/index.php?rid=3173513&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004768%2Fabstract%3Frss%3Dyes January 2010 marks a new chapter in this journal's history. Diabetes Research and Clinical Practice (DRCP) is now the official journal of the International Diabetes Federation (IDF), a development which reflects DRCP's increasing global importance and IDF's extensive global role. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173513 Fri, 04 Dec 2009 00:00:00 +0100 3173513 http://www.medworm.com/index.php?rid=3206160&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004690%2Fabstract%3Frss%3Dyes Abstract: Background and aims: Since there is no agreement on regimens of self-monitoring of blood glucose (SMBG) in type 2 diabetes not on insulin, we evaluated the effects of a simple SMBG policy taking into account compliance.Methods and results: 273 type 2 diabetic patients not on insulin with HbA1c >7% attending our Diabetes Clinic and already using SMBG were randomized as follows: Group A, one BG profile/month with fasting and post-prandial values; Group B, one BG profile every 2 weeks with pre- and post-prandial values. Patients were followed-up by the same team every 3 months with the same education and treatment policies. At 3 and 6 months, SMBG profiles were evaluated and HbA1c measured. SMBG was carried out as recommended by 73% of Group A and 44% of Group B patients. In complia... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206160 Wed, 02 Dec 2009 00:00:00 +0100 3206160 http://www.medworm.com/index.php?rid=3206146&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004732%2Fabstract%3Frss%3Dyes Conclusion: Plasma sRAGE is not significantly associated with urinary microalbumin excretion in the early stage of diabetic nephropathy while it is correlated positively with circulating AGE and negatively with glomerular filtration rate (GFR). (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206146 Mon, 30 Nov 2009 00:00:00 +0100 3206146 http://www.medworm.com/index.php?rid=3173532&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004720%2Fabstract%3Frss%3Dyes Abstract: The predictive value of hemoglobin A1c (HbA1c) in comparison to fasting plasma glucose (FPG) is evaluated for 5-year incident diabetes (DM), as HbA1c may be more practical than FPG in the screening for DM in the future. Of 1189 non-DM subjects aged 35–89 years old from the Funagata Study, 57 subjects (4.8%) had developed DM on the WHO criteria at 5-year follow-up. The odds ratio (95% confidence interval: CI) for a one standard deviation increase in FPG/HbA1c was 3.40 (2.44–4.74)/3.49 (2.42–5.02). The area under the receiver operating characteristic curve for FPG/HbA1c was 0.786 (95% CI: 0.719–0.853)/0.785 (0.714–0.855). The HbA1c corresponding to FPG 5.56mmol/l was HbA1c 5.3%. There was no statistical difference in sensitivity between FPG 5.56mmol/l and HbA1c 5.3% (61.4... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173532 Mon, 30 Nov 2009 00:00:00 +0100 3173532 http://www.medworm.com/index.php?rid=3206147&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004719%2Fabstract%3Frss%3Dyes Conclusions: These results indicate that ER stress can be uncoupled from oxidative stress and antioxidants can ameliorate the latter without altering the ER stress induced by hyperglycemia. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206147 Thu, 26 Nov 2009 00:00:00 +0100 3206147 http://www.medworm.com/index.php?rid=3173524&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004616%2Fabstract%3Frss%3Dyes Abstract: Aims: The present study sought to ascertain the prevalence of impaired awareness of hypoglycaemia (IAH) in people with insulin-treated Type 2 diabetes (T2DM) and its effect on risk of hypoglycaemia.Methods: Data were obtained from 122 people with insulin-treated T2DM (63 male; mean (SD) HbA1c 8.4% (1.5); median (inter quartile range, IQR) age, 67 (58–72) years; duration of T2DM 15 (10–20) years; duration of insulin therapy, 6 (4–9) years). A questionnaire was used to evaluate hypoglycaemia awareness status and estimate the frequency of severe hypoglycaemia (SH) in the preceding year. Capillary blood glucose was monitored prospectively over a 4-week period to document biochemical hypoglycaemia.Results: The prevalence of IAH was 9.8%. In the subgroup with IAH the incidence of... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173524 Thu, 26 Nov 2009 00:00:00 +0100 3173524 http://www.medworm.com/index.php?rid=3173523&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004598%2Fabstract%3Frss%3Dyes In this study, serum samples from Type 2 diabetic patients were added to the medium with J774.1 cells and the degree of foam cell induction was quantified by measuring lipid accumulation. These values were calculated relative to the activities of normal and WHHLMI rabbit sera as 0% and 100%, respectively, and termed the MMI (Macrophage Maturation Index). These MMI values reflected intracellular lipids, including cholesteryl ester assayed by GC/MS. Statistical analysis revealed MMI to correlate positively and independently with serum triglycerides, the state of diabetic retinopathy, nephropathy and obesity, but negatively with administration of α-glucosidase inhibitors or thiazolidinediones. Taken together, our results suggest that this novel assay may be applicable to the identification o... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173523 Thu, 26 Nov 2009 00:00:00 +0100 3173523 http://www.medworm.com/index.php?rid=3206161&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004689%2Fabstract%3Frss%3Dyes Abstract: Methods: The most recent nationally recognised guidelines for type 2 diabetes from eight European countries (Belgium, England/Wales, France, Germany, Ireland, Italy, the Netherlands and Sweden) were compared. The Appraisal of Guidelines for Research and Evaluation (AGREE) instrument was used for quality assessment. Details of recommendations for key process and outcome indicators were also extracted. Appraisal and data extraction were conducted independently by two researchers.Results: AGREE domain scores varied between guidelines, including a range of 31–95% for rigour of development. The highest mean domain scores were for Scope and Purpose (81%) and Clarity and Presentation (85%); the lowest was for Stakeholder Involvement (49%). Specific recommendations, including targets r... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206161 Mon, 23 Nov 2009 00:00:00 +0100 3206161 http://www.medworm.com/index.php?rid=3206158&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004653%2Fabstract%3Frss%3Dyes Abstract: The presence of white matter lesions (WML) is an important prognostic factor for the development of stroke. High-sensitivity C-reactive protein (HSCRP), which is associated with diabetes, has been flagged as a novel predictor for cerebrovascular events. This preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HSCRP and insulin resistance in type 2 diabetic patients not receiving insulin treatment.Based on brain magnetic resonance imaging (MRI) findings, 102 type 2 diabetic patients were divided into two groups; a WML-positive group (59±6 years, mean±SD, n=40) and a WML-negative group (58±6 years, n=62). The level of blood glucose was assessed by fasting plasma glucose (FPG), fasting immunoreactive insulin (F-IRI), homeostasi... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206158 Mon, 23 Nov 2009 00:00:00 +0100 3206158 http://www.medworm.com/index.php?rid=3173531&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004604%2Fabstract%3Frss%3Dyes Conclusions: In T2DM, increased WBC predicts cancer while use of RAS inhibitors may reduce cancer risks associated with high WBC count. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173531 Mon, 23 Nov 2009 00:00:00 +0100 3173531 http://www.medworm.com/index.php?rid=3173525&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900463X%2Fabstract%3Frss%3Dyes Conclusions: Evidence of association and an observed contribution to evidence for linkage to DI was observed for SNPs in DLG2 genotyped on the African-American individuals from the IRAS-FS. Although not the only gene in the region, these results suggest that variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin sensitivity and β-cell function as measured by DI. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173525 Mon, 23 Nov 2009 00:00:00 +0100 3173525 http://www.medworm.com/index.php?rid=3173522&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004355%2Fabstract%3Frss%3Dyes Conclusions: : The correlation between elevated NT-proBNP and Hcy levels in diabetic patients with LVDD suggest an association between homocysteinemia and increased NT-proBNP secretion. Our data indicate that NT-proBNP may be a simple screening tool to select diabetic patients with LVDD requiring further examination with echocardiography. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173522 Mon, 23 Nov 2009 00:00:00 +0100 3173522 http://www.medworm.com/index.php?rid=3206159&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004641%2Fabstract%3Frss%3Dyes Conclusions: In T1D patients with clinic BP120/70mmHg have higher presence of DR, and only will be identified through ABPM. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206159 Thu, 19 Nov 2009 00:00:00 +0100 3206159 http://www.medworm.com/index.php?rid=3206149&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004665%2Fabstract%3Frss%3Dyes In this study we compared plasma apelin concentrations in 101 patients with gestational diabetes (GDM) and 101 women with normal glucose tolerance (NGT) between 24 and 32 weeks of gestation (Group 1), as well as in 20 women with GDM and 16 subjects with NGT at term (Group 2). Apelin and APJ mRNA expression in subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and placental tissue were also measured in Group 2, using quantitative real-time PCR.Results: There were no significant differences in plasma apelin levels between the women with GDM and NGT (Group 1: 1555.6 [1281.2–1804.2]pg/ml vs 1656.5 [1430.2–1852.1]pg/ml, Group 2: 1607.9 [1453.4–1768.7]pg/ml vs 1493.8 [1316.8–1956.7]pg/ml) nor in apelin and APJ mRNA expression in SAT, VAT and placental tissue. Apelin mRNA ex... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206149 Thu, 19 Nov 2009 00:00:00 +0100 3206149 http://www.medworm.com/index.php?rid=3206145&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004628%2Fabstract%3Frss%3Dyes Abstract: Self-monitoring of blood glucose (SMBG) has been considered one major breakthrough in diabetes therapy because, for the first time, patients were able to determine their blood glucose levels during daily life. It seems obvious that this must be of advantage to disease management and clinical outcome, but it has become a nightmare for those trying to provide evidence. Randomised controlled trials have yielded inconsistent results on a benefit of SMBG-based treatment strategies not only in type 2 but – surprisingly – also in type 1 and gestational diabetes. Despite this, SMBG is being considered indispensible in intensive insulin treatment, but is being debated for other clinical settings. When considering the non-RCT based reasons for recommending SMBG in type 1 and gestationa... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206145 Thu, 19 Nov 2009 00:00:00 +0100 3206145 http://www.medworm.com/index.php?rid=3173521&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004343%2Fabstract%3Frss%3Dyes Conclusion: Elastic properties of aorta were abnormally changed in patients with NAFLD. Multiple hemodynamic abnormalities probably associated with insulin resistance may be accountable for abnormal elastic properties of aorta. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173521 Thu, 19 Nov 2009 00:00:00 +0100 3173521 http://www.medworm.com/index.php?rid=3344105&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004677%2Fabstract%3Frss%3Dyes Conclusion: Significant comorbid conditions in elderly diabetic patients with potential for inappropriate prescribing or treatment conflicts include arthritis, heart failure, chronic airways diseases and diseases treatable with systemic corticosteroids. Appropriate management of comorbidity should be included in guidelines for the elderly with diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344105 Wed, 18 Nov 2009 00:00:00 +0100 3344105 http://www.medworm.com/index.php?rid=3206143&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004306%2Fabstract%3Frss%3Dyes Abstract: The 42nd World Health Assembly (1989) issued a global call to action on the prevention and control of diabetes. Four regional diabetes declarations followed – Europe, the Americas, the Western Pacific, and Africa – which paved the way for national diabetes programmes (NDPs) in many countries.As a result of the UN Resolution on Diabetes (2006), the International Diabetes Federation (IDF) resolved to reinvigorate NDPs and established a Task Force for this purpose. Despite the growth of NDPs over the past 20 years, no formal global evaluation of their status appears to have been undertaken. Consequently, in 2008, the Task Force conducted a baseline survey of IDF member associations (n=202) worldwide seeking information on the existence, scope and status of NDPs. The survey achie... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206143 Wed, 18 Nov 2009 00:00:00 +0100 3206143 http://www.medworm.com/index.php?rid=3173516&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004318%2Fabstract%3Frss%3Dyes Abstract: Country and global health statistics underestimate the number of excess deaths due to diabetes. The aim of the study was to provide a more accurate estimate of the number of deaths attributable to diabetes for the year 2010. A computerized disease model was used to obtain the estimates. The baseline input data included the population structure, estimates of diabetes prevalence, estimates of underlying mortality and estimates of the relative risk of death for people with diabetes compared to people without diabetes.The total number of excess deaths attributable to diabetes worldwide was estimated to be 3.96 million in the age group 20–79 years, 6.8% of global (all ages) mortality. Diabetes accounted for 6% of deaths in adults in the African Region, to 15.7% in the North American... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173516 Wed, 18 Nov 2009 00:00:00 +0100 3173516 http://www.medworm.com/index.php?rid=3206144&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004288%2Fabstract%3Frss%3Dyes This article aims to provide an updated summary of diabetes prevention efforts by reviewing relevant literature published between 2007 and 2009. These include results from the long-term follow-up of diabetes prevention trials and the roll-out of community-based interventions in “real world” settings. Some countries have begun to implement population-based strategies for chronic disease prevention, but investment in developing and evaluating population-level interventions remains inadequate. By focussing on the “small change” approach and involving a number of different agencies, it may be possible to shift the population distribution of risk factors for diabetes and cardiovascular disease in a favourable direction. The cost-effectiveness of primary prevention strategies for type 2 ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206144 Fri, 13 Nov 2009 00:00:00 +0100 3206144 http://www.medworm.com/index.php?rid=3173529&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004331%2Fabstract%3Frss%3Dyes Conclusions: Statins do not appear to demonstrate a ‘class effect’ on IS in patients without diabetes. Differences between individual statins likely exist that may partially explain the findings of previously conducted meta-analyses examining the impact of statins on the development of diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173529 Fri, 13 Nov 2009 00:00:00 +0100 3173529 http://www.medworm.com/index.php?rid=3173515&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900432X%2Fabstract%3Frss%3Dyes Conclusion: These predictions, based on a larger number of studies than previous estimates, indicate a growing burden of diabetes, particularly in developing countries. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173515 Mon, 09 Nov 2009 00:00:00 +0100 3173515 http://www.medworm.com/index.php?rid=3173530&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900415X%2Fabstract%3Frss%3Dyes This study used claims data (10/2001 to 06/2005) from a privately insured U.S. population of adult T2D patients who were initiated on NPH or glargine following a 6-month insulin-free period. A sample of 1698 glargine-treated and 400 NPH-treated patients met the inclusion criteria. Total and diabetes-related costs (inflation-adjusted to 2006) were calculated for 6-month pre- and post-index periods and compared between 400 patient pairs matched by a propensity score method.Results: In the post-index 6-month period, glargine patients incurred higher diabetes-related drug costs than NPH patients ($785 versus $632, p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173530 Fri, 06 Nov 2009 00:00:00 +0100 3173530 http://www.medworm.com/index.php?rid=3173520&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004239%2Fabstract%3Frss%3Dyes Abstract: Aim: The study was undertaken to assess the protective effect of Spirulina fusiformis extract against Rosiglitazone induced osteoporosis and pharmacodynamic effects of Rosiglitazone with Spirulina in treating hyperglycemia and hyperlipidemia of insulin resistance rat.Method: For this aim, 30 Wistar albino rats were equally divided into five groups as control (C), diabetes mellitus (DM), diabetes mellitus+Rosiglitazone (DM+R), diabetes mellitus+Spirulina (DM+S), and diabetes mellitus+Rosiglitazone+Spirulina (DM+R+S). Serum glucose, triglyceride, HDL, LDL and insulin concentrations were estimated by routine standard methods in blood samples collected on 21th day. Integrity of the bone surface was examined by scanning electronic microscopy, and bone strength was measured by micro-ha... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173520 Fri, 06 Nov 2009 00:00:00 +0100 3173520 http://www.medworm.com/index.php?rid=3206157&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004173%2Fabstract%3Frss%3Dyes Abstract: The prevalence of end-stage renal disease (ESRD) is uprising in the paralleled with the increase of chronic kidney disease (CKD) patients. Diabetic nephropathy (DN) is the most important underlying disease of CKD and a leading cause of ESRD in Japan. Intensified multifactorial intervention in patients with type 2 diabetes with microalbuminuria slows the progression to nephropathy, and progression of retinopathy and autonomic neuropathy. However, further studies are needed to establish the effect of intensified multifactorial treatment on DN with overt proteinuria. In this trial, doctors and co-medicals collaborate to treat the DN patients to prevent the deterioration of DN by multifactorial intensive therapy. Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNET... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206157 Thu, 05 Nov 2009 00:00:00 +0100 3206157 http://www.medworm.com/index.php?rid=3173518&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004161%2Fabstract%3Frss%3Dyes Conclusions: Administration of mosapride increased bowel frequency and ameliorated symptoms of reflux and constipation possibly stimulating the lower intestine. Given that mosapride has those beneficial aspects, it may be a useful prokinetic agent in treating diabetic patients with constipation. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173518 Wed, 04 Nov 2009 00:00:00 +0100 3173518 http://www.medworm.com/index.php?rid=3344106&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003799%2Fabstract%3Frss%3Dyes Abstract: Aims: To examine the appropriate type and frequency of physical activity for the beneficial effect on hypertension and hyperglycemia.Methods: The incidence of hypertension and hyperglycemia was assessed using the results of annual physical checkups over 4 years for 5843 male employees aged 18–57 years old. Associations of different types of physical activity with the incidence of these two risk factors were examined with Cox proportional-hazard models.Results: There was a progressive reduction in the hazards ratios of hypertension with increasing total daily activity (hazards ratio of 0.65 (95% CI, 0.45–0.93) in subjects who walked >8000 steps/day vs. 3 times/week also showed a significantly lower risk (0.35; 0.13–0.96) of developing hypertension vs. those who exercised (So... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3344106 Mon, 02 Nov 2009 00:00:00 +0100 3344106 http://www.medworm.com/index.php?rid=3173535&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004227%2Fabstract%3Frss%3Dyes Abstract: The aim of this study was to verify the effect of resistance training and antioxidant supplementation on fat-free mass (FFM) and insulin sensitivity (IS). The results demonstrate that 6 months of resistance training combined with antioxidant supplementation significantly increased FFM without concomitant significant improvement in IS in older adults. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173535 Mon, 02 Nov 2009 00:00:00 +0100 3173535 http://www.medworm.com/index.php?rid=3206156&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004185%2Fabstract%3Frss%3Dyes Abstract: Aim: Diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD) but the relationship between DM and amnestic mild cognitive impairment (aMCI), characterized by isolated memory loss, is unclear. We studied the prevalence of MCI in DM patients.Methods: Neuropsychological status was evaluated using the Rivermead Behavioral Memory Test (RBMT) and the Mini Mental State Examination (MMSE). Subjects consisted of 103 consecutive diabetic patients hospitalized for diabetic education. Patients with severe diabetic complications or cerebrovascular accidents were excluded.Results: Neuropsychological evaluation of DM patients showed that 71% were normal (MMSE score ≥24 and RBMT score ≥15), 5% had amnestic MCI (aMCI) (MMSE score ≥24 and RBMT score (Source: Diabetes R... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206156 Fri, 30 Oct 2009 00:00:00 +0100 3206156 http://www.medworm.com/index.php?rid=3173528&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004148%2Fabstract%3Frss%3Dyes Conclusions: Given that diabetes in Vanuatu is likely to be significantly under-diagnosed and under-treated the current costs, while substantial are artificially low but are set to rise sharply with increased awareness of diabetes and growing rates of obesity. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173528 Fri, 30 Oct 2009 00:00:00 +0100 3173528 http://www.medworm.com/index.php?rid=3173519&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004197%2Fabstract%3Frss%3Dyes Abstract: The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-γ as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-γ was detected by ELISA. Results of this study showed that the serum level of IFN-γ was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group ha... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173519 Fri, 30 Oct 2009 00:00:00 +0100 3173519 http://www.medworm.com/index.php?rid=3206155&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004203%2Fabstract%3Frss%3Dyes Conclusion: Both patient groups achieved substantial reduction of HbA1c. Safety evaluation showed that fewer patients with T2 diabetes were affected by adverse events. According to that CSII treatment for patients with T2 diabetes is similarly effective with a slightly better safety profile. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206155 Mon, 26 Oct 2009 00:00:00 +0100 3206155 http://www.medworm.com/index.php?rid=3206154&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004215%2Fabstract%3Frss%3Dyes Conclusions: In patients with diabetes, aspirin therapy did not significantly reduce the risk of cardiovascular events without an increased risk of major bleeding, and showed sex-specific effects on MI and stroke. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3206154 Mon, 26 Oct 2009 00:00:00 +0100 3206154 http://www.medworm.com/index.php?rid=3173527&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004100%2Fabstract%3Frss%3Dyes Conclusions: In critically ill patients treated with catecholamine capillary fingerstick blood glucose measurement seems inaccurate. Earlobe sampling does not improve accuracy. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173527 Mon, 26 Oct 2009 00:00:00 +0100 3173527 http://www.medworm.com/index.php?rid=3173526&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003076%2Fabstract%3Frss%3Dyes Conclusion: Immigrants had a higher HbA1c concentration at baseline and after 12 months compared to natives, despite a similar decline in HbA1c percentage points. More investigations are warranted to identify the causes, such as dietary habits, language difficulties, education and others. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=3173526 Mon, 26 Oct 2009 00:00:00 +0100 3173526 http://www.medworm.com/index.php?rid=2975115&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004136%2Fabstract%3Frss%3Dyes Adetunji et al. remarkably observed a significant increase in the prevalence of anemia in diabetic patients with microalbuminuria and macroalbuminuria . Although early detection and correction of anemia is pivotal in people with diabetes, it might also be important in subjects with normal glucose metabolism. To investigate the association between anemia, glucose metabolism and urinary albumin creatinine ratio (ACR), we performed a retrospective analysis on the database of the Laboratory Information System of the Clinical Laboratory at the Verona University Hospital, to retrieve results of fasting plasma glucose (FPG), ACR and hemoglobin (Hb) tests performed on the whole cohort of outpatient adults (>35 years) referred by general practitioners for routine medical check-up in the past two ye... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975115 Fri, 16 Oct 2009 00:00:00 +0100 2975115 http://www.medworm.com/index.php?rid=2975107&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003866%2Fabstract%3Frss%3Dyes Conclusions: Age, diabetes family history, obesity, dyslipidemia and hypertension were all associated with the presence of diabetes in this study population. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975107 Fri, 16 Oct 2009 00:00:00 +0100 2975107 http://www.medworm.com/index.php?rid=2975098&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004112%2Fabstract%3Frss%3Dyes Abstract: Aims: To explore the role of asymmetric-dimethyl-l-arginine (ADMA), an endogenous nitric oxide synthetases (NOS) inhibitor, and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in early stages of type 1 diabetes mellitus.Methods: We measured in 99 female subjects with uncomplicated type 1 diabetes (duration disease (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975098 Fri, 16 Oct 2009 00:00:00 +0100 2975098 http://www.medworm.com/index.php?rid=2975106&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004094%2Fabstract%3Frss%3Dyes Conclusions: Risk factor control has improved in the United States. Persons newly diagnosed with type 2 diabetes in 2005 have a better prognosis than persons diagnosed with diabetes 11 years earlier. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975106 Thu, 15 Oct 2009 00:00:00 +0100 2975106 http://www.medworm.com/index.php?rid=2975097&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004124%2Fabstract%3Frss%3Dyes Conclusion: The present study provides evidence that a common haplotype of PPARGC1A genetic polymorphisms are moderately associated with T2D in Han Chinese population. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975097 Thu, 15 Oct 2009 00:00:00 +0100 2975097 http://www.medworm.com/index.php?rid=2975104&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003787%2Fabstract%3Frss%3Dyes Abstract: The activities of the enzymes to eliminate reactive oxygen species prevent the progression of atherosclerosis. We conducted a cross-sectional study among 3234 people that underwent total health check-up service, and studied the relationship between the serum superoxide dismutase (SOD) activity and risk factors of atherosclerosis or carotid artery intima-media thickness (IMT). Serum SOD activity negatively correlated with body mass index (BMI), systolic and diastolic blood pressure, serum triglyceride (TG) concentration and serum glucose concentration. Low serum SOD activity positively correlated with the carotid IMT thickening. But on the other hand, existence of carotid artery plaque positively correlated with serum SOD activity especially among men. Serum SOD activity negativel... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975104 Mon, 12 Oct 2009 00:00:00 +0100 2975104 http://www.medworm.com/index.php?rid=2877686&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003945%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877686 Sat, 10 Oct 2009 16:47:16 +0100 2877686 http://www.medworm.com/index.php?rid=2975112&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003854%2Fabstract%3Frss%3Dyes Abstract: The presence of metabolic syndrome (MetS) and its individual components is related to an increased IMT. MetS and increasing numbers of individual MetS components predicted future progression of IMT. Improvement of MetS was related to smaller increases in IMT, especially in females. These findings may suggest a benefit of intervention for MetS, which needs to be confirmed by prospective studies. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975112 Fri, 09 Oct 2009 00:00:00 +0100 2975112 http://www.medworm.com/index.php?rid=2975113&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003842%2Fabstract%3Frss%3Dyes Abstract: In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n=102) and control (n=193) groups differ significantly (p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975113 Thu, 08 Oct 2009 00:00:00 +0100 2975113 http://www.medworm.com/index.php?rid=2975102&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003817%2Fabstract%3Frss%3Dyes Conclusions: Podocyte and GBM change more obviously during the development of proteinuria. Besides, proteinuria was inversely related to podocyte density, and directly related to GBM and glomerular volume. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975102 Thu, 08 Oct 2009 00:00:00 +0100 2975102 http://www.medworm.com/index.php?rid=2975099&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004070%2Fabstract%3Frss%3Dyes Abstract: Aims: Metabolic syndrome (MetS) is associated with increased cardiovascular risk. We hypothesize that early vascular changes are already present at the time of diagnosis of MetS. The relationship of different measures of early vascular impairment with body fat distribution and the natural progression of MetS was examined in newly diagnosed subjects non-pharmacologically treated.Methods: 246 consecutively enrolled subjects were categorized according to the presence of MetS and type 2 diabetes (T2D). Intra-renal Doppler flow was used to ascertain resistive (RI) and pulsatility (PI) indices as markers of vascular resistance. Carotid intima-media thickness (IMT), cutis-rectis (CR) and rectis-aorta (RA) thicknesses were measured by ultrasonography; RA/CR ratio was used as measure of b... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975099 Thu, 08 Oct 2009 00:00:00 +0100 2975099 http://www.medworm.com/index.php?rid=2975105&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709004082%2Fabstract%3Frss%3Dyes Conclusions: : Due to higher ME effect of EIR on glycaemia is underestimated as compared with M/I. By correcting for ME valid estimates of relative contributions of insulin secretion and insulin sensitivity on glycaemia are obtained. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975105 Wed, 07 Oct 2009 00:00:00 +0100 2975105 http://www.medworm.com/index.php?rid=2975114&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003830%2Fabstract%3Frss%3Dyes Abstract: A total of 350 (184 males and 166 females) adults participated in the study. A sample of 138 individuals was selected randomly for genotyping. The synergistic effect of ACE (I/D) and ApoE (HhaI) on metabolic syndrome (MS) showed that individuals with e4/4+D/D combination had the highest occurrence of metabolic abnormalities. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975114 Mon, 05 Oct 2009 00:00:00 +0100 2975114 http://www.medworm.com/index.php?rid=2975111&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003775%2Fabstract%3Frss%3Dyes Abstract: Sodium-glucose cotransporters (SGLTs) in the kidney, may be involved in hypertension, diabetes and salt sensitivity. We evaluate the effect of losartan on blood pressure (BP) and SGLT2 expression in diabetic rats with high or normal salt diet. Losartan prevented an increase in BP and SGLT2 expression in diabetic rats. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975111 Mon, 05 Oct 2009 00:00:00 +0100 2975111 http://www.medworm.com/index.php?rid=2975109&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003805%2Fabstract%3Frss%3Dyes Abstract: Objective: To compare mortality risks among type 2 diabetes (T2D) patients being treated with glibenclamide, gliclazide, or glimepiride.Methods: Retrospective observational cohort studies of primary care-based diabetes register were carried out. Risk of total and cardiovascular (CVD) mortality was evaluated in cohort of T2D patients that were treated with either glibenclamide (n=50341), glimepiride (n=2479) or gliclazide (n=11368). Cox regression was used for multifactor evaluation. A cross-sectional evaluation of oral anti-diabetic drug (OAD) structure for 2005 and 2007 was also performed, as well as age at the time of death was compared in the timeframe between 2002 and 2007.Results: Total mortality was lower for gliclazide and glimepiride, vs. glibenclamide cohort: HRs 0.33 (9... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975109 Mon, 05 Oct 2009 00:00:00 +0100 2975109 http://www.medworm.com/index.php?rid=2975108&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003829%2Fabstract%3Frss%3Dyes Abstract: The purpose of this study was to determine levels of oral health knowledge and factors associated with adequate oral health knowledge in adults with diabetes. A convenience sample of 253 adult US residents with diabetes completed an oral health survey to assess their knowledge. Results showed that only 47% of the participants answered five or more (out of a maximum of seven) oral health knowledge items related to diabetes correctly. Participants who received oral health information related to diabetes have 2.9 times the odds of possessing adequate oral health knowledge (i.e., answered five or more items correctly) compared to participants who did not received that information controlling for education and race (OR=2.86, 95% CI 1.31–6.24, P=0.008). Given that oral health informa... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975108 Mon, 05 Oct 2009 00:00:00 +0100 2975108 http://www.medworm.com/index.php?rid=2975096&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003763%2Fabstract%3Frss%3Dyes We describe how systematic research may help to reconcile India's data deficits and may be applied towards prioritizing resource allocation and addressing shortfalls in disease prevention and control efforts. Expanding the scope of and contextualizing NCD health research in India may also have tremendous benefits for resource allocation and planning in other developing countries. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975096 Mon, 05 Oct 2009 00:00:00 +0100 2975096 http://www.medworm.com/index.php?rid=2975103&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003751%2Fabstract%3Frss%3Dyes Abstract: Aims: Executive function (EF) comprises a set of cognitive skills that controls the execution of complex activities. In the context of diabetes, this may include patients’ self-monitoring and daily management of their condition. We compared two different measures of EF in a population of elderly patients with type 2 diabetes mellitus (T2DM) and studied its relationship with diabetes self-care.Methods: Fifty patients (34 males) had EF assessed using Frontal Assessment Battery (FAB) and Executive Interview 25 (EXIT25). Diabetes self-care was assessed using the Summary of Diabetes Self-Care Activities (SDSCA) scale. Haemoglobin A1c (HbA1c), lipid levels, blood pressure and diabetes duration were recorded.Results: The mean age of the patients was 67.0±7.5 years and mean duration o... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975103 Mon, 28 Sep 2009 00:00:00 +0100 2975103 http://www.medworm.com/index.php?rid=2975110&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900374X%2Fabstract%3Frss%3Dyes Abstract: We performed a retrospective pooled analysis of 29 patients who had been diagnosed with fulminant type 1 diabetes in Korea and compared the results with 161 patients’ data from a nationwide survey in Japan. Fulminant type 1 diabetic patients in Korea have a similar phenotype compared with Japanese patients. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975110 Sun, 27 Sep 2009 00:00:00 +0100 2975110 http://www.medworm.com/index.php?rid=2975100&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003738%2Fabstract%3Frss%3Dyes Abstract: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It is characterized by chronic anovulation, hyperandrogenism, obesity and a predisposition to type 2 diabetes mellitus (T2DM). Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS. We typed six single nucleotide polymorphisms (haplotype tagging and/or previously associated with obesity or related metabolic traits) in PLIN in 305 unrelated non-Hispanic white women (185 with PCOS and 120 without PCOS). None of the variants was associated with PCOS (P (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975100 Sun, 27 Sep 2009 00:00:00 +0100 2975100 http://www.medworm.com/index.php?rid=2975101&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003726%2Fabstract%3Frss%3Dyes The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes.Methods: The subjects were 303 unrelated patients who were diagnosed with type 2 diabetes mellitus. To evaluate macroangiopathy, we measured carotid artery intima-media thickness (IMT) by ultrasonography. The MCP-1 A-2518G polymorphism was determined by TaqMan PCR method.Results: IMT in patients with the MCP-1 −2518 AG or GG genotype was significantly greater than the AA-genotype (P=0.007). Simple regression analysis showed that age, systolic blood pressure, LDL-cholesterol, the MCP-1 −2518 AG+GG polymorphism, and HbA1c level were correlated with IMT (P (Source: Diabetes Research and Clinical Pra... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975101 Fri, 25 Sep 2009 00:00:00 +0100 2975101 http://www.medworm.com/index.php?rid=2877697&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003702%2Fabstract%3Frss%3Dyes Abstract: Aims: To investigate the survival with diabetes in patients treated with insulin from diagnosis.Subjects and methods: We analyzed 845 subjects, 55.9% males, registered at “I. Pavel” Bucharest Diabetes Centre, insulin-treated from diagnosis, aged (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877697 Wed, 23 Sep 2009 23:00:00 +0100 2877697 http://www.medworm.com/index.php?rid=2877708&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003453%2Fabstract%3Frss%3Dyes Abstract: Type 2 diabetes mellitus (T2DM) is a growing worldwide problem with WHO estimates suggesting that 300 million people will be affected by 2025. T2DM could result in both microvascular and macrovascular complications but the presentation of these complications could vary globally and be influenced by diabetic control. We investigated the prevalence of these complications by surveying 787 patients of south-Asian origin in diabetic clinics in the UK (n=351), Mauritius (n=173) and India (n=263). We found the prevalence of microvascular complications such as retinopathy (India 16.3%; Mauritius 2.3%; UK 2.6%), nephropathy (India 20.5%; Mauritius 10.5%; UK 2.3%) and neuropathy (India 8.4%; Mauritius 1.2%; UK 5.1%) complications to be significantly higher in India compared to Mauritius an... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877708 Mon, 21 Sep 2009 23:00:00 +0100 2877708 http://www.medworm.com/index.php?rid=2877707&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900343X%2Fabstract%3Frss%3Dyes Yonem et al. reported that the concentrations of circulating asymmetric dimethylarginine (ADMA) and apelin are not altered as the type 2 diabetes mellitus (T2DM) progresses to microvascular complications . Although the number of patients in the subgroups was relatively small to make clearer comments, the results are interesting concerning several previous reports. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877707 Mon, 21 Sep 2009 23:00:00 +0100 2877707 http://www.medworm.com/index.php?rid=2877694&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003362%2Fabstract%3Frss%3Dyes Conclusions: The study shows the alarming growth of diabetes, IFG, and IGT in our country that warrants early aggressive intervention for prevention and management. We encourage the use of 2h post-glucose load aside from FBG in screening for true diabetics, IFGs, and IGTs. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877694 Mon, 21 Sep 2009 23:00:00 +0100 2877694 http://www.medworm.com/index.php?rid=2877691&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003416%2Fabstract%3Frss%3Dyes Conclusions: Compared to their White counterparts, African Americans with depressive symptoms accompanying diabetes are unlikely to discuss depression with healthcare professionals, be prescribed antidepressant medication, or be seen by a psychiatrist. Minority diabetes patients’ medical and psychiatric outcomes may improve if healthcare providers more actively initiate these discussions, provide culturally tailored education about the nature of depression and its management, incorporate patient preferences into treatment plans, and establish relationships with persons more likely to learn about African American patient symptoms. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877691 Mon, 21 Sep 2009 23:00:00 +0100 2877691 http://www.medworm.com/index.php?rid=2877709&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003696%2Fabstract%3Frss%3Dyes The objective of this study was to evaluate CFR and aortic distensibility indices in patients with different kinds of single-vessel coronary artery disease (SVD) with and without DM. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877709 Thu, 17 Sep 2009 23:00:00 +0100 2877709 http://www.medworm.com/index.php?rid=2877695&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003404%2Fabstract%3Frss%3Dyes Conclusions: Our findings suggest that health service access may explain some of the gender difference in the socioeconomic gradient of self-reported diabetes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877695 Sun, 13 Sep 2009 23:00:00 +0100 2877695 http://www.medworm.com/index.php?rid=2877692&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003684%2Fabstract%3Frss%3Dyes Conclusions: Increased lyso-PC contents in LDL were associated with the suppressed HTLase activity, and serum Lp-PLA2 and HTLase activities may be related to lyso-PC in type 2 diabetic patients. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877692 Sun, 13 Sep 2009 23:00:00 +0100 2877692 http://www.medworm.com/index.php?rid=2783535&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003532%2Fabstract%3Frss%3Dyes (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783535 Fri, 11 Sep 2009 16:29:57 +0100 2783535 http://www.medworm.com/index.php?rid=2877701&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003660%2Fabstract%3Frss%3Dyes We describe here a case of dual onset of type 1 DM accompanied by ketoacidosis, and Graves’ disease during the combination therapy via the autoimmune process. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877701 Thu, 10 Sep 2009 23:00:00 +0100 2877701 http://www.medworm.com/index.php?rid=2877700&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003428%2Fabstract%3Frss%3Dyes Abstract: The relationship between fasting glucose (FG) variability and nocturnal hypoglycemia was assessed using longitudinal data from PREDICTIVE™, the large-scale observational study of insulin detemir. An HbA1c-corrected correlation was found between these endpoints, suggesting FG variability can serve as a useful marker for this risk in clinical practice. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877700 Thu, 10 Sep 2009 23:00:00 +0100 2877700 http://www.medworm.com/index.php?rid=2877696&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003714%2Fabstract%3Frss%3Dyes Conclusions: The presence of CCR5Δ32 is associated with better survival in type 2 diabetes patients. These data suggest that it is worthwhile to explore the protective potential of pharmacological blockade of CCR5 in type 2 diabetic patients. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877696 Thu, 10 Sep 2009 23:00:00 +0100 2877696 http://www.medworm.com/index.php?rid=2877688&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003672%2Fabstract%3Frss%3Dyes Abstract: Adiponectin is an adipocytokine with insulin sensitizing effect while chronic inflammation damages pancreatic β-cells leading to reduced insulin response. We aimed to prove the hypothesis that adiponectin levels and inflammatory markers (white blood cell counts [WCC], Helicobacter pylori [HP] titers, high sensitivity C-reactive protein [hs-CRP]) may interact to affect risk of diabetes. We studied 288 Chinese men (age-median: 41.0 years, IQR: 35.3–46.0 years) being recruited from the community in Hong Kong. The mean adiponectin level was 5.39±2.81μg/ml and 40.9% (n=107) had low adiponectin level ( (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877688 Thu, 10 Sep 2009 23:00:00 +0100 2877688 http://www.medworm.com/index.php?rid=2877699&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003441%2Fabstract%3Frss%3Dyes Abstract: We evaluate the merits of routine waist circumference measurements for screening of impaired fasting glucose (IFG). Waist circumference and body mass index showed a strong association with the risk of IFG. The present data indicate the need for routine anthropometric measurements in clinical practice screening for IFG. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877699 Wed, 09 Sep 2009 23:00:00 +0100 2877699 http://www.medworm.com/index.php?rid=2877687&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003398%2Fabstract%3Frss%3Dyes Conclusions: Chronic inflammation and exogenous insulin usage increases serum syndecan-1 level. Exogenous insulin can promote shedding of syndecan-1 ectodomains to the serum in a time-dependent manner. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877687 Sun, 06 Sep 2009 23:00:00 +0100 2877687 http://www.medworm.com/index.php?rid=2877690&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003386%2Fabstract%3Frss%3Dyes Abstract: Objective: To determine risk factors in clinically significant macular edema (CSME) and if increased CSME in minorities is due to ethnicity or other factors in the Veterans Affairs Diabetes Trial (VADT).Methods: CSME prevalence based on 7-field stereo fundus photographs in 1268 patients with type 2 diabetes was related to ethnicity, demographics and biochemistries by univariate and multivariate analyses.Results: Hispanics (H) made up 17.5% and African Americans (AA) 17.7% of the cohort. CSME prevalence was 10%. In univariate analysis, CSME was more prevalent in H, 18%, and AA, 15.6% than in non-Hispanic Whites (NHW), 6.3%, p (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877690 Mon, 31 Aug 2009 23:00:00 +0100 2877690 http://www.medworm.com/index.php?rid=2877689&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709002678%2Fabstract%3Frss%3Dyes Conclusions: These data suggest that in adults at high risk for T2DM, depression treatment may improve insulin resistance observed in depression. Healthcare practitioners are encouraged to screen, treat, or refer their patients with depression for treatment. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877689 Mon, 31 Aug 2009 23:00:00 +0100 2877689 http://www.medworm.com/index.php?rid=2877693&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900312X%2Fabstract%3Frss%3Dyes Conclusions: IFG were common among Mongolian people living in the northeast of China. IFG has partly same risk factors as diabetes, and prevalence of some cardiovascular risk factors and number of risk factor in diabetes were higher than that in IFG. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877693 Wed, 26 Aug 2009 23:00:00 +0100 2877693 http://www.medworm.com/index.php?rid=2877704&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003039%2Fabstract%3Frss%3Dyes Abstract: As cyclin-dependant kinase 4 (CDK4) regulates beta cell proliferation, it may confer T2D risk. We tested the CDK4 IVS4-nt40A→G SNP for association with T2D in Italians (230 cases, 204 control subjects) and excluded a role of the variant in our dataset. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877704 Wed, 19 Aug 2009 23:00:00 +0100 2877704 http://www.medworm.com/index.php?rid=2877703&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003118%2Fabstract%3Frss%3Dyes Abstract: In contrast to the autoimmune type 1 diabetes, patients with monogenic diabetes due to KCNJ11 mutations do not have pancreatic auto-antibodies at onset. Here we describe a patient diagnosed at the age of 12 weeks that showed ICA at diagnosis, yet has been tested with positive result for KCNJ11 mutation. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2877703 Tue, 18 Aug 2009 23:00:00 +0100 2877703 http://www.medworm.com/index.php?rid=2783540&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003052%2Fabstract%3Frss%3Dyes Abstract: Aim: The aim of this study was to compare the effect of continuation or discontinuation of glimepiride upon starting insulin therapy in type 2 diabetic patients poorly controlled with sub-maximal glimepiride.Methods: This 48-week, randomized, observational, parallel-group study consisted of a 24-week screening period and a 24-week intervention period. During the screening period, we unified the sulfonylureas to glimepiride at 3mg/day for 8 weeks, and started biphasic insulin aspart 30 (Asp30Mix) once-daily injections for 16 weeks. At the start of the intervention period, we stepped up once- to twice-daily insulin injection and randomized the 26 patients into either continuation of glimepiride group (CONT, n=14) or discontinuation of glimepiride group (DISCON, n=12). The Asp30Mix ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783540 Tue, 18 Aug 2009 23:00:00 +0100 2783540 http://www.medworm.com/index.php?rid=2783541&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709002939%2Fabstract%3Frss%3Dyes Abstract: Aims/hypothesis: Intra-abdominal fat (IAF) and inflammatory markers are correlated with cardio-vascular risk. We compared the impact of bed-time insulin versus pioglitazone treatment on these parameters in type 2 diabetic (T2D) patients.Methods: Twenty-eight T2D patients poorly controlled with metformin and sulfonylurea were randomized to receive add-on therapy with pioglitazone or bed-time NPH insulin. IAF and subcutaneous fat (SCF) content, systemic low-grade inflammation level and expression of inflammation related genes in SCF, were measured before and after 24 weeks of treatment.Results: Insulin and pioglitazone resulted in a significant decrease in HbA1c (−1.6% and −1.2%, respectively) and a significant increase in total body fat mass (1±2.3 and 3.3±2.7kg, respectivel... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783541 Sun, 16 Aug 2009 23:00:00 +0100 2783541 http://www.medworm.com/index.php?rid=2783538&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS016882270900309X%2Fabstract%3Frss%3Dyes Conclusions: ARI counteracts the decreased adhesion of HCECs induced by high glucose exposure, through the modulation of the expression of MMP-10. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783538 Sun, 16 Aug 2009 23:00:00 +0100 2783538 http://www.medworm.com/index.php?rid=2783547&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003027%2Fabstract%3Frss%3Dyes Abstract: Aim: To estimate hazard ratio (HR) of first incident fatal/non-fatal cardiovascular diseases (CVD) in female/male type 2 diabetic patients, with tight versus adverse control of HbA1c and blood pressure (BP) at baseline, age 30–70 years, no baseline CVD, followed for mean 5.7 years.Methods: 2593 patients with tight control of HbA1c (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783547 Wed, 12 Aug 2009 23:00:00 +0100 2783547 http://www.medworm.com/index.php?rid=2783542&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003040%2Fabstract%3Frss%3Dyes Abstract: The aim of the study was to evaluate the long-term effect of rosiglitazone and metformin monotherapy with medical nutrition treatment (MNT) and of MNT alone on arterial stiffness, serum monocyte chemoattractant protein (MCP)-1 and matrix metalloproteinase (MMP)-9 in drug naive patients with type 2 diabetes mellitus. Fifty type 2 diabetic patients were randomized to receive rosiglitazone 4mg/day (n=19) or metformin 850mg/day (n=16) with MNT or MNT alone (n=15), for 52 weeks. Arterial stiffness was assessed by using large and small artery elasticity index (SAEI and LAEI, respectively). SAEI, LAEI, serum MCP-1 and MMP-9 levels were measured at baseline and following 52 weeks of treatment. SAEI was improved only in the rosiglitazone group, and the difference was still statistically s... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783542 Wed, 12 Aug 2009 23:00:00 +0100 2783542 http://www.medworm.com/index.php?rid=2783537&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003106%2Fabstract%3Frss%3Dyes Abstract: Aim: Culture of cells in simulated microgravity may be potentially beneficial to the fields of cell biology and somatic cell therapy. We aimed to examine three-dimensional culture condition on pancreatic islets.Methods: Islets of Langerhans were cultured in conditions of stasis, microgravity, and microgravity with a polyglycolic acid (PGA) fibrous scaffold. After 5 days in culture, islets were transplanted into the leg muscles of streptozotocin-treated diabetic Wistar rats. The blood glucose and insulin content were determined from the tail vein blood of recipients. The grafts were then frozen, dried, and coated for analysis by scanning electron microscopy.Results: Grafts cultured in the three-dimensional conditions (simulated microgravity in the presence or absence of a PGA fibr... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783537 Wed, 12 Aug 2009 23:00:00 +0100 2783537 http://www.medworm.com/index.php?rid=2975116&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709002654%2Fabstract%3Frss%3Dyes Swinnen and DeVries raise the important issue of cost-effectiveness with basal insulins, but we feel their conclusion that detemir will regularly oblige relatively high unit doses is scientifically unsound. The trials they cite reported higher doses of detemir than comparators, but possible responsible methodological factors were explained in an earlier publication by DeVries et al. . (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2975116 Wed, 12 Aug 2009 00:00:00 +0100 2975116 http://www.medworm.com/index.php?rid=2783545&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709001521%2Fabstract%3Frss%3Dyes Abstract: Aims: To study the impact of genetic factor on pancreatic β-cell function in the Chinese population.Methods: 233 first-degree relatives of patients with type 2 diabetes (T2D) with no history of blood glucose abnormalities and their 190 spouses, who did not have a family history of T2D, underwent a 75-g oral glucose tolerance test (OGTT). Based upon the OGTT, these two groups were further divided into three subgroups, including groups with normal glucose tolerance (NGT), impaired glucose regulation (IGR), and type 2 diabetes. Insulin resistance (IR) was evaluated using the homeostasis model assessment–IR (HOMA-IR), β-cell function indices of basal and first-phase were measured by DI1 (HOMA-β/HOMA-IR) and DI2 (ΔI30/ΔG30/HOMA-IR), respectively.Results: Among the first-degree ... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783545 Tue, 11 Aug 2009 23:00:00 +0100 2783545 http://www.medworm.com/index.php?rid=2783544&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709001594%2Fabstract%3Frss%3Dyes Abstract: Aim: To evaluate cardiovascular risk in prediabetes (IFG and IGT) assessed by serum lipid and hsCRP levels.Subjects and methods: 445 subjects with prediabetes (248 with IFG, 197 with IGT), 318 patients with newly-diagnosed diabetes (NDD) and a group of 477 age- and BMI-matched subjects with normal glucose tolerance (NGT) were enrolled. Glucose tolerance was studied during oral glucose tolerance test (OGTT) and 2006 WHO criteria were applied. Serum hsCRP and lipids (total cholesterol, triglycerides, HDL-cholesterol (HDL-c) and free fatty acids (FFAs) were measured.Results: Both IFG and IGT showed significantly atherogenic changes in serum lipid and hsCRP levels when compared to NGT. Subjects with IGT presented with significantly higher triglycerides (p=0.01) and FFAs (p (Source: D... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783544 Tue, 11 Aug 2009 23:00:00 +0100 2783544 http://www.medworm.com/index.php?rid=2783546&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003088%2Fabstract%3Frss%3Dyes Conclusions: Higher levels of GHb were associated with increased total and CHD mortality within the first six years independent of cardiac risk factors. Though further research is needed, this supports the hypothesis that early glycemic control may affect mortality outcomes. (Source: Diabetes Research and Clinical Practice) Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783546 Mon, 10 Aug 2009 23:00:00 +0100 2783546 http://www.medworm.com/index.php?rid=2783539&cid=s_35513_15_f&fid=35513&url=http%3A%2F%2Fwww.diabetesresearchclinicalpractice.com%2Farticle%2FPIIS0168822709003064%2Fabstract%3Frss%3Dyes This study explored cultural individualist and collectivist aspects of self-management and their relationship to diabetes control.Methods: 94 Adults with type 2 diabetes for over 1 year and Chinese spoken as a first language at home recruited through healthcare providers completed the newly developed Diabetes Management Orientation Scale (DMOS), and a validated Diabetes Self-Efficacy Scale (DSES). Exploratory factor analysis and logistic regression was used to examine the factor structure and relationship to glycemic control.Results: Three factors were extracted from the DMOS: Individualist, Collectivist, and Balanced Personal Responsibility (BPR) Orientations to self-management. BPR orientation was the only significant psychosocial predictor of glycemic control in this population (odds ra... Diabetes Research and Clinical Practice journals http://www.medworm.com/rss/comments.php?id=2783539 Mon, 10 Aug 2009 23:00:00 +0100 2783539