MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diabetes and Metabolism' source. Sat, 20 Mar 2010 14:12:57 +0100 http://www.medworm.com/index.php?rid=3374977&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226708%26dopt%3DAbstract CONCLUSION: To best assess peak postprandial glucose levels, the optimal time for blood glucose monitoring is about 1h and 15min after the start of the meal, albeit with wide interpatient variability. Nevertheless, 80% of post-meal blood glucose peaks were observed at less than 90min after the start of the meal. PMID: 20226708 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3374977 Wed, 10 Mar 2010 00:00:00 +0100 3374977 http://www.medworm.com/index.php?rid=3358328&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20219404%26dopt%3DAbstract CONCLUSION: This study shows that previously published algorithms for computer-aided diagnosis is a reliable alternative to time-consuming manual analysis of fundus photographs when screening for DR. The use of this system would allow considerable timesavings for physicians and, therefore, alleviate the time spent on a mass-screening programme. PMID: 20219404 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3358328 Mon, 08 Mar 2010 00:00:00 +0100 3358328 http://www.medworm.com/index.php?rid=3338810&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20202879%26dopt%3DAbstract CONCLUSION: The combined use of low adiponectin levels and large WC measures has greater discriminative power than using either index alone to identify subjects at particular risk of glucose intolerance and clustering of risk factors. PMID: 20202879 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3338810 Tue, 02 Mar 2010 00:00:00 +0100 3338810 http://www.medworm.com/index.php?rid=3338809&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20202880%26dopt%3DAbstract CONCLUSION: The prevalence of the MetS is markedly high within the population of Great Tunis and especially in women. As these findings predict future increases in cardiovascular disease in these populations, substantial efforts need to be made to fight against obesity and sedentary lifestyles to ameliorate the expected poor health outcomes. PMID: 20202880 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3338809 Tue, 02 Mar 2010 00:00:00 +0100 3338809 http://www.medworm.com/index.php?rid=3323255&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20189425%26dopt%3DAbstract The objectives of this review are to summarize the importance of screening for SMI in a subset of asymptomatic diabetic patients. There is evidence that screening markedly improves the evaluation of cardiovascular risk compared with the usual risk scores. New markers, validated by large-scale studies, are needed to help in identifying the patients with silent coronary stenoses, thereby lowering the number of screened patients. Some indications of benefit with revascularization in patients with silent coronary stenoses are also available. Although it is not yet time to stop screening diabetic patients for SMI, such screening should focus on patients who are at high or intermediate cardiovascular risk. Guidelines need to be updated to increase the value of screening. PMID: 20189425 [PubM... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3323255 Thu, 25 Feb 2010 00:00:00 +0100 3323255 http://www.medworm.com/index.php?rid=3323256&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20188617%26dopt%3DAbstract CONCLUSION: Insulin glargine use throughout pregnancy does not appear to be associated with an increased rate of severe congenital malformations. PMID: 20188617 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3323256 Wed, 24 Feb 2010 00:00:00 +0100 3323256 http://www.medworm.com/index.php?rid=3312782&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20181508%26dopt%3DAbstract CONCLUSION: The In2it((R)) analyzer is suitable for HbA(1c) assay in small laboratory series and for point-of-care testing, and its analytical performance is satisfactory overall. However, several issues related to software need to be improved for optimal application. Also, special attention should be paid concerning the possibility of underestimation of results in cases of high hypertriglyceridaemia. PMID: 20181508 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3312782 Mon, 22 Feb 2010 00:00:00 +0100 3312782 http://www.medworm.com/index.php?rid=3270338&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149705%26dopt%3DAbstract CONCLUSION: These data show that obese Zucker rats display age-related alterations of IR gene expression at both pre- and post-translational stages and, in particular, increased endocytosis and degradation of IR protein. PMID: 20149705 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3270338 Tue, 09 Feb 2010 00:00:00 +0100 3270338 http://www.medworm.com/index.php?rid=3270337&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149706%26dopt%3DAbstract CONCLUSION: Mostly self-controlled exercise of moderate intensity ameliorated serum levels of pro- and anti-atherogenic markers in patients with T2DM, with no effects on body weight. These data offer further insight into the cardioprotective mechanisms of exercise in patients with T2DM. PMID: 20149706 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3270337 Mon, 08 Feb 2010 00:00:00 +0100 3270337 http://www.medworm.com/index.php?rid=3258918&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20137994%26dopt%3DAbstract CONCLUSION: This study suggests an independent association between skin AF levels and diabetic nephropathy and neuropathy, but not retinopathy, in T1D patients. Prospective studies are needed to confirm the ability of skin AF levels to predict microangiopathy. PMID: 20137994 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3258918 Thu, 04 Feb 2010 00:00:00 +0100 3258918 http://www.medworm.com/index.php?rid=3232293&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116316%26dopt%3DAbstract CONCLUSION: French diabetic patients subsequent to MI undergo fewer angioplasty procedures than do non-diabetic patients. After the acute stage, secondary preventative medications are used more often, with a marked rise in the use of insulin. PMID: 20116316 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3232293 Wed, 27 Jan 2010 00:00:00 +0100 3232293 http://www.medworm.com/index.php?rid=3232292&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116317%26dopt%3DAbstract CONCLUSION: The DR screening campaign represents a major improvement in diabetic management, as around 80% of the screened patients with DR consulted an ophthalmologist after the screening campaign. However, the overall rate of diabetics having the recommended annual ophthalmological visit in the region of Burgundy remained unchanged. PMID: 20116317 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3232292 Wed, 27 Jan 2010 00:00:00 +0100 3232292 http://www.medworm.com/index.php?rid=3221447&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20106702%26dopt%3DAbstract CONCLUSION: Glucose levels greater than 8.8mmol/L on postoperative day 1 and having three or more hypoglycaemic episodes in the postoperative period were predictive of mortality and morbidity among patients undergoing cardiovascular surgery. This suggests that a multidisciplinary approach may be able to achieve better postoperative blood glucose control. PMID: 20106702 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3221447 Mon, 25 Jan 2010 00:00:00 +0100 3221447 http://www.medworm.com/index.php?rid=3208815&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20097589%26dopt%3DAbstract CONCLUSION: This study showed that a BG target of 100-139mg/dL can be safely achieved with an insulin therapy protocol that can be routinely used in everyday clinical practice. PMID: 20097589 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3208815 Fri, 22 Jan 2010 00:00:00 +0100 3208815 http://www.medworm.com/index.php?rid=3208816&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20097112%26dopt%3DAbstract CONCLUSION: Cassava consumption in South Kivu is not associated with changes in T2D phenotype or in the glucose homoeostasis determinants S, B, BxS and BxS LR. Cassava consumption does not accelerate beta-cell function loss in such a population, whose markedly compromised glucose homoeostasis renders them vulnerable to environmentally acquired beta-cell impairment. PMID: 20097112 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3208816 Thu, 21 Jan 2010 00:00:00 +0100 3208816 http://www.medworm.com/index.php?rid=3208817&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20096618%26dopt%3DAbstract Authors: Vergnes JN PMID: 20096618 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3208817 Wed, 20 Jan 2010 00:00:00 +0100 3208817 http://www.medworm.com/index.php?rid=3201972&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20093061%26dopt%3DAbstract Authors: Rötig A Oxidative phosphorylation - ATP synthesis by the oxygen-consuming respiratory chain (RC) - supplies most organs and tissues with a readily usable energy source, and is already fully functioning at birth. This means that, in theory, RC deficiency can give rise to any symptom in any organ or tissue at any age and with any mode of inheritance, due to the two-fold genetic origin of RC components (nuclear DNA and mitochondrial DNA). It has long been erroneously believed that RC disorders originate from mutations of mtDNA as, for some time, only mutations or deletions of mtDNA could be identified. However, the number of disease-causing mutations in nuclear genes is now steadily growing. These genes not only encode the various subunits of each complex, but also the ancil... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3201972 Tue, 19 Jan 2010 00:00:00 +0100 3201972 http://www.medworm.com/index.php?rid=3190014&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20080427%26dopt%3DAbstract Authors: Friedlander AH PMID: 20080427 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3190014 Fri, 15 Jan 2010 00:00:00 +0100 3190014 http://www.medworm.com/index.php?rid=3179548&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20074990%26dopt%3DAbstract When to treat a diabetic patient using an external insulin pump. Expert consensus. Société francophone du diabète (ex ALFEDIAM) 2009. Diabetes Metab. 2010 Jan 12; Authors: Lassmann-Vague V, Clavel S, Guerci B, Hanaire H, Leroy R, Loeuille GA, Mantovani I, Pinget M, Renard E, Tubiana-Rufi N For years, external insulin pumps have enjoyed proven efficacy as an intensive diabetes treatment to improve glycaemic control and reduce hypoglycaemia. Since the last ALFEDIAM guidelines in 1995, however, basal-bolus treatment using a combination of long- and short-acting insulin analogues have emerged and could challenge, at a lower cost, the efficacy of pumps using rapid-acting insulin analogues, considered the 'gold standard' of insulin treatment. Nevertheless, given its th... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3179548 Tue, 12 Jan 2010 00:00:00 +0100 3179548 http://www.medworm.com/index.php?rid=3179547&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20074991%26dopt%3DAbstract CONCLUSION: Elevated maternal ferritin is not a reflection of excess iron stores, but is related to an increased risk of GDM or IUGR. Also, maternal ferritin levels are not associated with either neonatal iron status or neonatal outcomes. PMID: 20074991 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3179547 Tue, 12 Jan 2010 00:00:00 +0100 3179547 http://www.medworm.com/index.php?rid=3167541&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20060765%26dopt%3DAbstract CONCLUSION: LADA patients demonstrate lower residual beta-cell function than do type 2 diabetes patients. However, those who achieve tight metabolic control do not present with a rapid decline in beta-cell function. Further studies are needed to determine the optimal treatment strategy in such patients. PMID: 20060765 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3167541 Thu, 07 Jan 2010 00:00:00 +0100 3167541 http://www.medworm.com/index.php?rid=3143296&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20045370%26dopt%3DAbstract CONCLUSION: The increased production of PGF(2alpha) probably proceeds, at least in part, independently of the COX pathway and via the isoprostane route. However, it is unclear whether the relatively high levels of PGF(2alpha) are causally related to, or simply coincidental with, fetal malformation. PMID: 20045370 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3143296 Wed, 30 Dec 2009 00:00:00 +0100 3143296 http://www.medworm.com/index.php?rid=3126989&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20036596%26dopt%3DAbstract CONCLUSION: These results indicate the presence of significant lipid peroxidation, protein oxidation and oxidative DNA damage in patients with diabetes. Perturbation of glucose homoeostasis was associated with an increase in oxidants and a concomitant decrease of antioxidant enzymes in the type 2 diabetic patients' blood. The present study suggests that the status of oxidant-antioxidant imbalance may be one of the mechanisms leading to the DNA damage detected in the lymphocytes of type 2 diabetic patients. PMID: 20036596 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3126989 Thu, 24 Dec 2009 00:00:00 +0100 3126989 http://www.medworm.com/index.php?rid=3101291&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20006530%26dopt%3DAbstract CONCLUSION: Overall, the self-reported prevalence of CVRF among elderly patients with diabetes did not improve during 1995-2006 but, instead, showed significant increases in self-reported obesity and HBP. This lack of improvement calls for further investigations, and the dedicated attention of both healthcare providers and the diabetic patients themselves. PMID: 20006530 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3101291 Fri, 11 Dec 2009 00:00:00 +0100 3101291 http://www.medworm.com/index.php?rid=3045306&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19945895%26dopt%3DAbstract CONCLUSION: Desflurane in vitro was able to postcondition diabetic (both ID and NID) human myocardium at 6 and 9%, but not at 3%. PMID: 19945895 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3045306 Fri, 27 Nov 2009 00:00:00 +0100 3045306 http://www.medworm.com/index.php?rid=3027347&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932633%26dopt%3DAbstract Authors: Daroux M, Prevost G, Maillard-Lefebvre H, Gaxatte C, D'Agati VD, Schmidt AM, Boulanger E Glycation is the process whereby sugars bind to the free amine residues of proteins. These newly formed modified molecular species are known as 'advanced glycation end-products', or AGEs. AGE toxicity may occur through at least three mechanisms: interaction with the receptor for AGEs (RAGE); tissue deposition; and in situ glycation. AGEs trigger proinflammatory, profibrotic and procoagulant cellular responses that are capable of damaging tissues, often targeting particular organs. In diabetic patients, the conditions needed to promote AGE formation are all present, and are further accentuated by accompanying renal failure. The aim of this review is to outline the involvement of AGEs in the... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3027347 Fri, 20 Nov 2009 00:00:00 +0100 3027347 http://www.medworm.com/index.php?rid=3004742&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19914853%26dopt%3DAbstract CONCLUSION: In type 1 diabetic patients treated with FIT, the use of individualized parameters permits fast and accurate adjustment of mealtime insulin doses, leading to good control of the postprandial state. PMID: 19914853 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3004742 Fri, 13 Nov 2009 00:00:00 +0100 3004742 http://www.medworm.com/index.php?rid=3004743&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19914118%26dopt%3DAbstract CONCLUSION: Patients treated with insulin detemir in a clinical healthcare setting improved their glycaemic control with no increases in hypoglycaemia, adverse events or weight compared with baseline. PMID: 19914118 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3004743 Thu, 12 Nov 2009 00:00:00 +0100 3004743 http://www.medworm.com/index.php?rid=2981456&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19897394%26dopt%3DAbstract CONCLUSION: These findings suggest that women with the metabolic syndrome in early pregnancy have a greater risk of developing GDM. PMID: 19897394 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2981456 Fri, 06 Nov 2009 00:00:00 +0100 2981456 http://www.medworm.com/index.php?rid=2981455&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19897395%26dopt%3DAbstract CONCLUSION: IIEF-5-defined ED in men with T2DM is associated with a marked increase in the metabolic syndrome, central adiposity and microangiopathy. These data suggest that diagnosing ED in T2DM warrants detailed screening and monitoring for microangiopathy in target organs. PMID: 19897395 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2981455 Fri, 06 Nov 2009 00:00:00 +0100 2981455 http://www.medworm.com/index.php?rid=2970754&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19892578%26dopt%3DAbstract CONCLUSION: Further implementation of screening programmes is the key to improving DR diagnosis and preventing vision loss in the French diabetic population. PMID: 19892578 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2970754 Tue, 03 Nov 2009 00:00:00 +0100 2970754 http://www.medworm.com/index.php?rid=2931560&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19854668%26dopt%3DAbstract CONCLUSION: LMF1 expression was not altered in this experimental animal model of obesity, insulin resistance and diabetes in the presence of raised TG levels. However, metformin increased LMF1 expression in the heart, suggesting that stimulation of LMF1 may play a part in its TG-lowering action. PMID: 19854668 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2931560 Fri, 23 Oct 2009 00:00:00 +0100 2931560 http://www.medworm.com/index.php?rid=2905735&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19836986%26dopt%3DAbstract Authors: Al-Hajeri T, El-Gebely S, Abdella N A 35-year-old morbidly obese man, diagnosed with type 2 diabetes in 2006, lost nearly 100kg extremely rapidly soon after the diagnosis, with dramatic painful paraesthesia and autonomic neuropathy, and poor diabetes control. Investigations to find a tumour, or an infectious, endocrinological or digestive disease, to explain his clinical features were all negative. However, with insulin and analgesic treatment, the patient's symptoms improved markedly within a few months; the patient gained 50kg, while insulin was tapered and then withdrawn, to be replaced by metformin, which maintained perfect diabetes control. Also, the analgesic therapies could be discontinued. This case report is typical of diabetic neuropathic cachexia, first described by... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2905735 Wed, 14 Oct 2009 23:00:00 +0100 2905735 http://www.medworm.com/index.php?rid=2891525&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19819740%26dopt%3DAbstract CONCLUSION: Increased PP is a powerful independent risk predictor of CVD in type 2 diabetic patients, and lowering PP can lead to a marked reduction in risk. PMID: 19819740 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2891525 Thu, 08 Oct 2009 23:00:00 +0100 2891525 http://www.medworm.com/index.php?rid=2891526&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19818665%26dopt%3DAbstract CONCLUSION: These data confirm the influential role of the FTO gene in obesity in the French female population and, in addition, revealed the role of FTO in insulin resistance and MetS. These effects appeared to be independent of IRS-2, which is directly involved in insulin action. This study may offer new insights into the genetic determinants of obesity and MetS in women. PMID: 19818665 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2891526 Tue, 06 Oct 2009 23:00:00 +0100 2891526 http://www.medworm.com/index.php?rid=2880170&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19815442%26dopt%3DAbstract Authors: Meas T For several years now, the epidemiological data have shown an inverse relationship between birth-weight and the development in later life of cardiovascular disease and metabolic disorders. The term "small for gestational age" (SGA) describes a neonate whose birth-weight is two standard deviations (SD) below the reference mean, corrected for gestational age and gender. SGA is associated with increased risks of developing hypertension, insulin resistance and type2 diabetes. However, the association with an atherogenic lipid profile is less clear. Nevertheless, all of the components of the metabolic syndrome are present. Yet, in spite of the large body of data in the literature, the biological mechanisms underlying this association are still unclear. To explain the associa... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2880170 Mon, 05 Oct 2009 23:00:00 +0100 2880170 http://www.medworm.com/index.php?rid=2880169&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19815443%26dopt%3DAbstract CONCLUSIONS: Receptor engagement by distinct AGEs differentially enhances expression of RAGE isoforms and DRBC adhesion. The CML-adduct, by facilitating adhesion, has more deleterious effects than MG-derived AGEs. PMID: 19815443 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2880169 Mon, 05 Oct 2009 23:00:00 +0100 2880169 http://www.medworm.com/index.php?rid=2852194&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19786360%26dopt%3DAbstract Authors: Halimi JM, Asmar R, Ribstein J Results from the ONTARGET trial remind us that acute haemodynamically mediated renal dysfunction, triggered by low arterial pressure or volume depletion, can occur in high-risk cardiovascular patients (who usually have some degree of diseased intrarenal vessels) treated with renin-angiotensin system (RAS) blockers (especially in combination). However, nephroprotection could not be properly assessed in the trial, as the population was at low renal risk. Although albuminuria remains a useful marker in many patients, it can neither predict acute renal dysfunction nor replace end-stage renal disease (ESRD) as the endpoint in clinical trials. Recent trials using surrogate endpoints suggest that some RAS blockers (ACE inhibitors, angiotensin receptor b... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2852194 Fri, 25 Sep 2009 23:00:00 +0100 2852194 http://www.medworm.com/index.php?rid=2816721&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766032%26dopt%3DAbstract CONCLUSION: The proposed protocol using IM insulin can be safely used to treat hyperglycaemic crises, with mortality rates comparable to those in specialized centres in developed countries. PMID: 19766032 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2816721 Tue, 15 Sep 2009 23:00:00 +0100 2816721 http://www.medworm.com/index.php?rid=2801125&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19747869%26dopt%3DAbstract CONCLUSION: Regular aerobic exercise begun during pregnancy may have favourable effects on glucose tolerance and fitness in obese women, and warrants further investigation in a larger sample population. PMID: 19747869 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2801125 Tue, 08 Sep 2009 23:00:00 +0100 2801125 http://www.medworm.com/index.php?rid=2778826&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19734081%26dopt%3DAbstract CONCLUSION: The new index proposed by Bastard et al. is as good a predictor of IS in sedentary men as the other commonly used indices, and appears to be as reliable in this population as it was in the original study of postmenopausal women. PMID: 19734081 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2778826 Thu, 03 Sep 2009 23:00:00 +0100 2778826 http://www.medworm.com/index.php?rid=2778827&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19733492%26dopt%3DAbstract Authors: Vergès B Patients with type 1 diabetes (T1D) also present with lipid disorders. Quantitative abnormalities of lipoproteins are observed in T1D patients with poor glycaemic control (increased plasma triglycerides and low-density lipoprotein [LDL] cholesterol) or nephropathy (increased triglycerides and LDL cholesterol, low level of high density lipoprotein [HDL] cholesterol). In cases of T1D with optimal glycaemic control, plasma triglycerides and LDL cholesterol are normal or slightly decreased, while HDL cholesterol is normal or slightly increased. Several qualitative abnormalities of lipoproteins, which are potentially atherogenic, are observed in patients with T1D, even in those with good metabolic control. These abnormalities include increased cholesterol-to-triglycer... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2778827 Wed, 02 Sep 2009 23:00:00 +0100 2778827 http://www.medworm.com/index.php?rid=2753125&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19716740%26dopt%3DAbstract Authors: Roussel R, Cosson E PMID: 19716740 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2753125 Wed, 26 Aug 2009 23:00:00 +0100 2753125 http://www.medworm.com/index.php?rid=2744459&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19713141%26dopt%3DAbstract CONCLUSION: These findings indicate that telmisartan attenuated fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells. Our observations pave the way to the possible use of ARB as a means of protecting beta-cell survival and preserving insulin secretion capacity in patients with diabetes mellitus. PMID: 19713141 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2744459 Mon, 24 Aug 2009 23:00:00 +0100 2744459 http://www.medworm.com/index.php?rid=2731003&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19700362%26dopt%3DAbstract Authors: Kakleas K, Kandyla B, Karayianni C, Karavanaki K Adolescents with diabetes are at increased risk of developing psychiatric (10-20%) or eating disorders (8-30%), as well as substance abuse (25-50%), leading to non-compliance with treatment and deterioration of diabetic control. At high risk are female adolescents with family problems and other comorbid disorders. Impaired cognitive function has also been reported among children with diabetes, mainly in boys, and especially in those with early diabetes diagnosis (< 5 years), or with episodes of severe hypoglycaemia or prolonged hyperglycaemia. Type 1 diabetes mellitus contributes to the development of problems in parent-child relationships and employment difficulties, and negatively affects the quality of life. However, insul... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2731003 Thu, 20 Aug 2009 23:00:00 +0100 2731003 http://www.medworm.com/index.php?rid=2709687&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19683953%26dopt%3DAbstract CONCLUSION: In type 2 diabetic patients with poor diabetic control, obstructive SAS is highly prevalent and related to abdominal obesity, and should be systematically screened for, as it cannot be predicted by the clinical data. PMID: 19683953 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2709687 Thu, 13 Aug 2009 23:00:00 +0100 2709687 http://www.medworm.com/index.php?rid=2692764&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19665414%26dopt%3DAbstract CONCLUSION: The prevalences of diabetes and IFG have increased dramatically over the past decade. Yet, a large proportion of cases go undiagnosed. These results suggest an urgent need to establish regular population-based diabetes screening in Guangzhou. PMID: 19665414 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2692764 Wed, 05 Aug 2009 23:00:00 +0100 2692764 http://www.medworm.com/index.php?rid=2692763&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19665415%26dopt%3DAbstract CONCLUSION: In subjects at high risk of developing diabetes, the use of metformin showed beneficial and no untoward effects on cardiometabolic risk factors. PMID: 19665415 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2692763 Wed, 05 Aug 2009 23:00:00 +0100 2692763 http://www.medworm.com/index.php?rid=2671706&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19648048%26dopt%3DAbstract CONCLUSION: During the development of disease of ZDF rats, sympathovagal balance might account for the lack of increase in PWV. PMID: 19648048 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2671706 Thu, 30 Jul 2009 23:00:00 +0100 2671706 http://www.medworm.com/index.php?rid=2671707&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19647467%26dopt%3DAbstract CONCLUSION: Prophylactic injections of regular human insulin were well tolerated, but failed to prevent type 1 diabetes onset in IA-2A+ relatives. PMID: 19647467 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2671707 Wed, 29 Jul 2009 23:00:00 +0100 2671707 http://www.medworm.com/index.php?rid=2671708&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19646908%26dopt%3DAbstract CONCLUSION: In patients with DM, local inflammatory activation is diffuse and correlates with systemic inflammation. However, low systemic inflammatory activation does not always predict an increase in local thermal heterogeneity. PMID: 19646908 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2671708 Tue, 28 Jul 2009 23:00:00 +0100 2671708 http://www.medworm.com/index.php?rid=2638250&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19625203%26dopt%3DAbstract CONCLUSION: Variation in the FTO gene modifies weight, adiposity and other measures of obesity and insulin sensitivity in PCOS. The examined FTO gene variant appears to have a greater impact on obesity and related traits in PCOS than in other phenotypes. The effect on insulin sensitivity appears to be secondary to its influence on obesity and body fat. PMID: 19625203 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2638250 Sun, 19 Jul 2009 23:00:00 +0100 2638250 http://www.medworm.com/index.php?rid=2593362&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19589712%26dopt%3DAbstract CONCLUSION: Bedtime insulin led to an early and specific reduction in REE. PMID: 19589712 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2593362 Mon, 06 Jul 2009 23:00:00 +0100 2593362 http://www.medworm.com/index.php?rid=2563454&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19570704%26dopt%3DAbstract CONCLUSION: Combining abnormal CR-R parameters (I - E and I/E the most specific) with HRV-PS (particularly the LF area with the subject standing) allowed diagnosis of diabetic CAN at an earlier stage. PMID: 19570704 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2563454 Sun, 28 Jun 2009 23:00:00 +0100 2563454 http://www.medworm.com/index.php?rid=2561715&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19560388%26dopt%3DAbstract CONCLUSION: This is the first randomised study showing that CGM improves glycaemic control in patients with T2D. PMID: 19560388 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2561715 Wed, 24 Jun 2009 23:00:00 +0100 2561715 http://www.medworm.com/index.php?rid=2533001&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539513%26dopt%3DAbstract Authors: Bourlier V, Bouloumie A Obesity is associated with systemic chronic low-grade inflammation, a major contributor to the aetiology of insulin resistance (IR). An inflammatory response in the presence of obesity appears to be triggered by, and to reside predominantly in, adipose tissue (AT). The discovery that the AT in obese mice and humans is infiltrated with macrophages has provided a major advance in our understanding of how obesity propagates inflammation. Interestingly, AT-infiltrating macrophages exhibit a proinflammatory phenotype (classical activation) whereas macrophages residing in AT have a reparative phenotype (alternative activation). In this review, the processes involved in monocyte/macrophage recruitment into the AT, and the events underlying the activation of in... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533001 Mon, 15 Jun 2009 23:00:00 +0100 2533001 http://www.medworm.com/index.php?rid=2533000&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19539514%26dopt%3DAbstract Authors: Bonomo M, Cairoli R, Verde G, Morelli L, Moreo A, Delle Grottaglie M, Brambilla MC, Meneghini E, Aghemo P, Corigliano G, Marroni A PMID: 19539514 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533000 Mon, 15 Jun 2009 23:00:00 +0100 2533000 http://www.medworm.com/index.php?rid=2533002&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19502091%26dopt%3DAbstract CONCLUSION: Gliclazide and glibenclamide have different effects on the changes induced by prolonged exposure of human islet cells to high levels of glucose. PMID: 19502091 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533002 Thu, 04 Jun 2009 23:00:00 +0100 2533002 http://www.medworm.com/index.php?rid=2533013&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19349201%26dopt%3DAbstract Authors: Dumas JF, Simard G, Flamment M, Ducluzeau PH, Ritz P The precise cause of insulin resistance and type 2 diabetes is unknown. However, there is a strong association between insulin resistance and lipid accumulation - and, in particular, lipotoxic fatty acid metabolites - in insulin-target tissues. Such accumulation is known to cause insulin resistance, particularly in skeletal muscle, by reducing insulin-stimulated glucose uptake. Reduced fat-oxidation capacity appears to cause such lipid accumulation and, over the past few years, many studies have concluded that decreased mitochondrial oxidative phosphorylation could be the initiating cause of lipid deposition and the development of insulin resistance. The aim of this review is to summarize the latest findings regarding the li... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533013 Sun, 31 May 2009 23:00:00 +0100 2533013 http://www.medworm.com/index.php?rid=2533012&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19349202%26dopt%3DAbstract CONCLUSION: This evaluation shows that Ophdiat((R)), combined with the availability of modern and effective devices, has improved DR screening in diabetology departments in hospitals. Additional human resources would certainly ensure more effective use of the system. PMID: 19349202 [PubMed - in process] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533012 Sun, 31 May 2009 23:00:00 +0100 2533012 http://www.medworm.com/index.php?rid=2533010&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19419896%26dopt%3DAbstract CONCLUSION: The present study identifies changes in PAI-1 levels and genetic variations at the PAI-1 locus as risk factors for DR, but not DR severity, that may serve as useful markers of increased DR susceptibility. PMID: 19419896 [PubMed - in process] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533010 Sun, 31 May 2009 23:00:00 +0100 2533010 http://www.medworm.com/index.php?rid=2533007&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19446486%26dopt%3DAbstract Authors: Vischer UM, Bauduceau B, Bourdel-Marchasson I, Blickle JF, Constans T, Fagot-Campagna A, Kaloustian E, Lassman-Vague V, Lecomte P, Simon D, Tessier D, Verny C, Doucet J, The prevalence of type 2 diabetes increases with age. However, the management of diabetes in the elderly has received surprisingly little attention. Diabetes in the elderly is associated with a high risk of geriatric syndromes including malnutrition and sarcopenia, functional impairments, falls and fractures, incontinence, depression and dementia. Tight glycaemic control for the prevention of vascular complications is often of limited value in the elderly. However, glycaemic control and non-pharmacological therapy may prevent diabetes symptoms and delay geriatric syndromes. The prevention, screening and treat... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533007 Sun, 31 May 2009 23:00:00 +0100 2533007 http://www.medworm.com/index.php?rid=2533005&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19457690%26dopt%3DAbstract Authors: Antuna-Puente B, Disse E, Lavoie ME, Rabasa-Lhoret R, Laville M, Bastard JP PMID: 19457690 [PubMed - in process] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533005 Sun, 31 May 2009 23:00:00 +0100 2533005 http://www.medworm.com/index.php?rid=2533003&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19481965%26dopt%3DAbstract Authors: Martin RJ, Maxwell AP, Patterson CC, McKnight AJ, Savage DA, PMID: 19481965 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533003 Sun, 31 May 2009 23:00:00 +0100 2533003 http://www.medworm.com/index.php?rid=2533004&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19473866%26dopt%3DAbstract Authors: Pollock NW PMID: 19473866 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533004 Sun, 24 May 2009 23:00:00 +0100 2533004 http://www.medworm.com/index.php?rid=2533006&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447061%26dopt%3DAbstract CONCLUSION: These findings constitute the first study in humans of ANGPTL6 genetic variability. Although there was no evidence that polymorphisms in ANGPTL6 might be significantly associated with the metabolic syndrome-related phenotypes, a weak association of these polymorphisms with these parameters cannot be excluded. Further association studies are needed to arrive at any definite conclusions. PMID: 19447061 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533006 Wed, 13 May 2009 23:00:00 +0100 2533006 http://www.medworm.com/index.php?rid=2533009&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19423377%26dopt%3DAbstract CONCLUSION: In this cross-sectional study, the ACR in LADA and in T2D were similar and higher than in T1D. This similarity between LADA and T2D makes it unlikely that the autoimmune processes that operate in LADA promote albuminuria. PMID: 19423377 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533009 Mon, 04 May 2009 23:00:00 +0100 2533009 http://www.medworm.com/index.php?rid=2533008&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19423378%26dopt%3DAbstract CONCLUSION: Our study confirmed that, in a population of Afro-Caribbean hypertensive type 2 diabetic patients, renal failure was associated to an increased left ventricular mass/height(2.7). The data show that the variables associated with LVH differ according to renal profile. This finding will be of value in the treatment and follow-up of these patients. PMID: 19423378 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533008 Mon, 04 May 2009 23:00:00 +0100 2533008 http://www.medworm.com/index.php?rid=2533011&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19419895%26dopt%3DAbstract Authors: Serino M, Luche E, Chabo C, Amar J, Burcelin R Recent advances in molecular sequencing technology have allowed researchers to answer major questions regarding the relationship between a vast genomic diversity-such as found in the intestinal microflora-and host physiology. Over the past few years, it has been established that, in obesity, type 1 diabetes and Crohn's disease-to cite but a few-the intestinal microflora play a pathophysiological role and can induce, transfer or prevent the outcome of such conditions. A few of the molecular vectors responsible for this regulatory role have been determined. Some are related to control of the immune, vascular, endocrine and nervous systems located in the intestines. However, more important is the fact that the intestinal microflora-t... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2533011 Sun, 03 May 2009 23:00:00 +0100 2533011 http://www.medworm.com/index.php?rid=2308332&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19342262%26dopt%3DAbstract We describe here a rather different phenotype: two cases of adult diabetic patients-considered and treated as insulin-dependent diabetic patients since adolescence-who, in fact, turned out to be heterozygous for an ABCC8 mutation and able to successfully discontinue insulin while taking sulphonylurea treatment. PMID: 19342262 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2308332 Tue, 31 Mar 2009 04:00:00 +0100 2308332 http://www.medworm.com/index.php?rid=2287637&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19303338%26dopt%3DAbstract CONCLUSIONS: DIABASIS provides important information for diabetes care by highlighting patients' views of the disease, such as distress at diagnosis, lack of adequate information to cope with this distress and the important supportive role played by the family. A deeper understanding of patients' perception of the disease would help optimize customized care. PMID: 19303338 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2287637 Wed, 18 Mar 2009 04:00:00 +0100 2287637 http://www.medworm.com/index.php?rid=2287640&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19299181%26dopt%3DAbstract CONCLUSION: Short-term, single lifestyle modifications targeting the metabolic syndrome in collaboration with GPs was effective in decreasing most of the parameters of the syndrome. However, no factors predictive of success were identified. PMID: 19299181 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2287640 Tue, 17 Mar 2009 04:00:00 +0100 2287640 http://www.medworm.com/index.php?rid=2277095&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19297223%26dopt%3DAbstract CONCLUSION: DPN and DPN-P are frequent complications of diabetes, especially in type 2, and can be identified with inexpensive and easy-to-use screening tools. Despite its profound impact on QoL, DPN-P remains undertreated. PMID: 19297223 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2277095 Mon, 16 Mar 2009 04:00:00 +0100 2277095 http://www.medworm.com/index.php?rid=2277094&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19297224%26dopt%3DAbstract CONCLUSION: Low levels of IGFBP-1 predicted the long-term development of type 2 diabetes or IGT in a middle-aged population. The association was independent of CRP and abdominal obesity. PMID: 19297224 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2277094 Mon, 16 Mar 2009 04:00:00 +0100 2277094 http://www.medworm.com/index.php?rid=2251521&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19269874%26dopt%3DAbstract CONCLUSION: Our data confirms that smoking may be an independent risk factor for type 2 diabetes. PMID: 19269874 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2251521 Fri, 06 Mar 2009 05:00:00 +0100 2251521 http://www.medworm.com/index.php?rid=2251520&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19269875%26dopt%3DAbstract Authors: Del Guerra S, Lupi R, D'Aleo V, Filipponi F, Boggi U, Marchetti P PMID: 19269875 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2251520 Fri, 06 Mar 2009 05:00:00 +0100 2251520 http://www.medworm.com/index.php?rid=2116004&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19150252%26dopt%3DAbstract CONCLUSION: The beneficial effect of benfluorex as add-on therapy in lowering HbA(1c) at W18 was maintained at W34 without evidence for a loss of efficacy or an increased incidence of side effects over a 34-week follow-up. PMID: 19150252 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2116004 Wed, 14 Jan 2009 05:00:00 +0100 2116004 http://www.medworm.com/index.php?rid=2061209&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19101189%26dopt%3DAbstract CONCLUSION: In AN, both high and low cholesterol-rich LP levels were observed. Low T3 and low catabolism allow LP to be maintained, while CETP activity increases cholesterol turnover as an adaptation to its low intake. In severely malnourished AN patients, this fails and LP drops. On the other hand, LP values were higher in the bingeing-purging type of AN than in the restrictive type. Recovery from AN results in the normalization of the LP profile. PMID: 19101189 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2061209 Thu, 18 Dec 2008 05:00:00 +0100 2061209 http://www.medworm.com/index.php?rid=2061208&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19101190%26dopt%3DAbstract CONCLUSION: Our results indicate that chronic treatment with LA aggravates energy imbalances in diabetic animals. Moreover, our data suggest the need to reconsider the use of LA as an adjuvant in the prevention and treatment of type 1 diabetes. PMID: 19101190 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=2061208 Thu, 18 Dec 2008 05:00:00 +0100 2061208 http://www.medworm.com/index.php?rid=1895258&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930691%26dopt%3DAbstract CONCLUSION: Compared with either moderate physical endurance or dietary restriction, a combination of both resulted in a significant decrease in cardiovascular risk factors and HOMA-IR index in obese adolescent boys. PMID: 18930691 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1895258 Fri, 17 Oct 2008 04:00:00 +0100 1895258 http://www.medworm.com/index.php?rid=1859670&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18838325%26dopt%3DAbstract CONCLUSION: This first systematic search for HNF1A mutations in a Polish population revealed that they are a frequent cause of MODY. In this population, HNF1A mutation carriers were characterized by a high prevalence of diabetic complications. In addition, renal developmental abnormalities were found in some mutation carriers. PMID: 18838325 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1859670 Tue, 30 Sep 2008 04:00:00 +0100 1859670 http://www.medworm.com/index.php?rid=1531508&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18562232%26dopt%3DAbstract CONCLUSION: HG and/or HI per se regulated the concentrations and expression of leptin, adiponectin and ASP in healthy lean young men, suggesting a contribution to dysregulation of these hormones in diabetes. PMID: 18562232 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1531508 Mon, 16 Jun 2008 04:00:00 +0100 1531508 http://www.medworm.com/index.php?rid=1531507&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18562233%26dopt%3DAbstract Authors: Girard J, Lafontan M Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low levels of high-density lipoprotein cholesterol that contribute to the development of type-2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver. The secreted products interact with hepatocytes and various immune cells in the liver. Altered liver metabolism and determinants of insulin resistance associated with visceral adipose tissue distribution are discussed, as well as, determinants of an insulin-resistant state promoted by the increased free fatty acids and cytokines delivered by visceral adipos... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1531507 Mon, 16 Jun 2008 04:00:00 +0100 1531507 http://www.medworm.com/index.php?rid=1368473&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358419%26dopt%3DAbstract Authors: Girard J, Danchin N, Vergès B PMID: 18358419 [PubMed - in process] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368473 Fri, 01 Feb 2008 05:00:00 +0100 1368473 http://www.medworm.com/index.php?rid=1368472&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358420%26dopt%3DAbstract Authors: Feuvray D, Darmellah A Although the pathogenesis of diabetic cardiomyopathy is poorly understood, recent evidence implicates perturbations in cardiac energy metabolism. Whereas mitochondrial fatty acid oxidation is the chief energy source for the normal postnatal mammalian heart, the relative contribution of glucose utilization pathways is significant, allowing the plasticity necessary for steady ATP production in the context of diverse physiologic and dietary conditions. In the uncontrolled diabetic state, because of the combined effects of insulin resistance and high circulating fatty acids, cardiac myocytes use fatty acids almost exclusively to support ATP synthesis. Studies using various diabetic rodent models have shown a direct relationship between the chronic drive on m... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368472 Fri, 01 Feb 2008 05:00:00 +0100 1368472 http://www.medworm.com/index.php?rid=1368471&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358421%26dopt%3DAbstract Authors: Vergès B, Zeller M, Beer JC, Cottin Y, Plasma N-terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) level has been shown to provide valuable prognostic information on short and long-term mortality in patients with acute Myocardial Infarction, in the general population. Increased plasma Nt-proBNP levels have been found in Type 2 diabetic patients with vascular complications or with hypertension. In a large prospective study performed in 560 patients hospitalized for acute Myocardial Infarction (RICO), we found that median Nt-proBNP levels were significantly higher in the 199 diabetic patients compared to the 361 non-diabetic patients (245 (81-77) vs. 130 (49-199) pmol/L, P<0.0001). This difference remained highly significant after adjustment for confounding factors and ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368471 Fri, 01 Feb 2008 05:00:00 +0100 1368471 http://www.medworm.com/index.php?rid=1368470&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358422%26dopt%3DAbstract Authors: Massy ZA, Mentaverri R, Mozar A, Brazier M, Kamel S There is increasing evidence to suggest that the initiation of vascular calcification is an active process involving vascular smooth muscle cell (VSMC) apoptosis and trans-differentiation into calcifying cells. This active process results in the deposition of an osteogenic extracellular matrix and may be exacerbated by a reduction in the levels of one or more native calcification inhibitors (such as fetuin A and pyrophosphate). Here, we present data which strongly suggest that the regression of vascular calcification might also be an active cellular process involving osteoclast-like cells. However, the presence of osteoclast like cells in the vascular wall is rather limited. To explain this rarity of osteoclast-like cells, we... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368470 Fri, 01 Feb 2008 05:00:00 +0100 1368470 http://www.medworm.com/index.php?rid=1368469&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358423%26dopt%3DAbstract Authors: Boutouyrie P Arterial stiffness is now included in the guidelines of the European Society of Hypertension. In this paper, we review the evidence for the predictive value of arterial stiffness. More than 11 longitudinal trials have proven the predictive value of aortic stiffness measured through carotid to femoral pulse wave velocity, beyond and above classical risk factors. Such evidence is scarcer for central pressure and local arterial stiffness. If we add this evidence to the easiness of performing such measure, carotid to femoral pulse wave velocity is the reference technique for assessing arterial stiffness. Its place in the investigation of patients remains to be precised. PMID: 18358423 [PubMed - in process] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368469 Fri, 01 Feb 2008 05:00:00 +0100 1368469 http://www.medworm.com/index.php?rid=1368468&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358424%26dopt%3DAbstract Authors: Leroyer AS, Tedgui A, Boulanger CM Cell activation or apoptosis leads to plasma membrane blebbing and microparticles (MPs) release in the extracellular space. MPs are submicron membrane vesicles, which harbour a panel of oxidized phospholipids and proteins specific to the cells they derived from. MPs are found in the circulating blood of healthy volunteers. MPs levels are increased in many diseases, including cardiovascular diseases with high thrombotic risk. Exposure of negatively charged phospholipids and tissue factor confers a procoagulant potential to MPs. Elevation of plasma MPs levels, particularly those of endothelial origin, reflects cellular injury and appears now as a surrogate marker of vascular dysfunction. Recent studies demonstrate an elevation of circulating le... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368468 Fri, 01 Feb 2008 05:00:00 +0100 1368468 http://www.medworm.com/index.php?rid=1368467&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358425%26dopt%3DAbstract Authors: Silvestre JS Advances in the field of vascular biology lead to the identification of endothelial progenitor cells (EPC) and to the development of EPC-based cell therapy to induce new vessel formation in ischemic tissues and to accelerate re-endothelialisation of injured vessels in human and various animals models. However, recent studies have shown that age and other risk factors for cardiovascular diseases, such as diabetes, reduce the availability of EPC and impair their function to varying degrees, leading to reduction in postischemic vessel growth. This review focus on the cellular and molecular mechanisms governing EPC-related functions and analyzes the impact of diabetes in this setting. PMID: 18358425 [PubMed - in process] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368467 Fri, 01 Feb 2008 05:00:00 +0100 1368467 http://www.medworm.com/index.php?rid=1368466&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18358426%26dopt%3DAbstract Authors: Hadjadj S, Saulnier PJ, Torremocha F, Labbé L, Maréchaud R Current recommendations regarding glycemic control suggest that HbA(1c) should be lower than 6.5%. This is supported by data regarding microvascular disease, namely retinopathy rather than nephropathy. The question is not completely solved regarding cardiovascular diseases, where a strategy of very low HbA(1c) ("the lower the better") is expected to be effective. Some ongoing studies will help to answer these unsolved questions. PMID: 18358426 [PubMed - in process] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1368466 Fri, 01 Feb 2008 05:00:00 +0100 1368466 http://www.medworm.com/index.php?rid=1207720&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18243026%26dopt%3DAbstract CONCLUSION: Distribution of abdominal fat, as evaluated by MRI, can be reflected by clinical determination of the WHR. Differences in regional accumulations of abdominal fat may be specifically related to variations in the risks of steatosis and vascular rigidity among obese type 2 diabetic patients. PMID: 18243026 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1207720 Thu, 31 Jan 2008 05:00:00 +0100 1207720 http://www.medworm.com/index.php?rid=1207719&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18243027%26dopt%3DAbstract CONCLUSION: IL-1Ra, leptin and adiponectin serum levels exhibit marked interindividual variation with high intraindividual consistency. A gender-based dimorphic pattern for IL-1Ra, independent of the degree of adiposity and glucose control, was also found. PMID: 18243027 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1207719 Thu, 31 Jan 2008 05:00:00 +0100 1207719 http://www.medworm.com/index.php?rid=1207722&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18242113%26dopt%3DAbstract Authors: Galtier F, Raingeard I, Renard E, Boulot P, Bringer J The obesity epidemic is of some concern in women of reproductive age. Maternal obesity is associated with many pregnancy complications, especially gestational diabetes and hypertensive disorders of pregnancy. Delivery in obese women is characterized by a high caesarean-section rate and an increased risk of anaesthetic and postoperative complications. Weight retention after birth may increase the risk of type 2 diabetes in the long term. Foetal risks include macrosomia, malformations and increased perinatal mortality, with the long-term infant health marked by a higher risk of obesity and metabolic disorders. Optimal management includes preconception counselling, pregravid weight-loss programmes, monitoring of gestational we... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1207722 Wed, 30 Jan 2008 05:00:00 +0100 1207722 http://www.medworm.com/index.php?rid=1207721&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18242114%26dopt%3DAbstract Authors: Hartemann-Heurtier A, Senneville E Bone infection in the diabetic foot is always a complication of a preexisting infected foot wound. Prevalence can be as high as 66%. Diagnosis can be suspected in two mains conditions: no healing (or no depth decrease) in spite of appropriate care and off-loading, and/or a visible or palpated bone with a metal probe. The first recommended diagnostic step is to perform (and if necessary to repeat) plain radiographs. After a four-week treatment period, if plain radiographs are still normal, suspicion for bone infection will persist in case of bad evolution despite optimized management of off-loading and arterial disease. It is only in such cases that other diagnosis methods than plain radiographs must be used. Staphylococcus aureus is the most ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1207721 Wed, 30 Jan 2008 05:00:00 +0100 1207721 http://www.medworm.com/index.php?rid=1109882&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18093861%26dopt%3DAbstract Authors: Antuna-Puente B, Feve B, Fellahi S, Bastard JP White adipose tissue was believed to be just an energy-storage organ, but it is now recognized to be an active participant in energy homoeostasis and physiological functions such as immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Adipose tissue is known to express and secrete a variety of products known as 'adipokines', including leptin, adiponectin, resistin and visfatin, as well as cytokines and chemokines such as tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1. The release of adipokines by either adipocytes or adipose tissue-infiltrated macrophages leads to a chronic subinflammatory state that could play a central role in the d... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1109882 Mon, 17 Dec 2007 05:00:00 +0100 1109882 http://www.medworm.com/index.php?rid=1085769&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18069029%26dopt%3DAbstract In conclusion, even over a medium-term period, in-stent restenosis remains a potential risk for coronary diabetic patients treated with drug-eluting devices. PMID: 18069029 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1085769 Fri, 07 Dec 2007 05:00:00 +0100 1085769 http://www.medworm.com/index.php?rid=1085768&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18069030%26dopt%3DAbstract Authors: Guerre-Millo M The discoveries of leptin and adiponectin were breakthroughs in the field of metabolic diseases. Adipose cells produce both proteins and release them into the circulation. Leptin acts as a fundamental signal for the brain to modulate food intake as a function of energy status. Loss of leptin function results in obesity. Although a biological role for adiponectin has not been firmly established, clinical and experimental observations indicate that low plasma levels contribute to the pathogenesis of insulin resistance, type 2 diabetes and cardiovascular diseases in obese or overweight patients. Adiponectin circulates as several multimeric species, including a high-molecular-weight form thought to be the most clinically relevant. Adiponectin exerts anti-atherogenic... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1085768 Fri, 07 Dec 2007 05:00:00 +0100 1085768 http://www.medworm.com/index.php?rid=1085767&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18069031%26dopt%3DAbstract CONCLUSION: Using a standardized simple protocol during labour, maternal glycaemia was maintained within a near-normal range in 80-85% of cases. PMID: 18069031 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1085767 Fri, 07 Dec 2007 05:00:00 +0100 1085767 http://www.medworm.com/index.php?rid=1085770&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18068386%26dopt%3DAbstract CONCLUSION: Cardiovascular risk profiles reported by providers in T2D people are high. Despite recent progress, there is a need for major improvement in practices intended to prevent cardiovascular disease in these people, especially in those at greatest CHD risk. PMID: 18068386 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1085770 Thu, 06 Dec 2007 05:00:00 +0100 1085770 http://www.medworm.com/index.php?rid=1080434&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18063403%26dopt%3DAbstract CONCLUSION: HFrD led to alterations of SCD-1, GLUT-4 and PGC-1alpha, which may be early markers of insulin resistance. PMID: 18063403 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1080434 Tue, 04 Dec 2007 05:00:00 +0100 1080434 http://www.medworm.com/index.php?rid=1047994&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18035572%26dopt%3DAbstract CONCLUSION: T1D adolescent girls display an altered sympathoadrenergic activity at rest and during intense exercise. Their reduced sympathetic activity, albeit probably compensated for by higher adrenomedullary responsiveness or sensitivity, does not affect their heart rate adaptations to exercise. PMID: 18035572 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1047994 Tue, 20 Nov 2007 05:00:00 +0100 1047994 http://www.medworm.com/index.php?rid=1041656&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18024110%26dopt%3DAbstract We present the first case of muscle infarction in a 30-year-old woman who had a 5-year history of type 1 diabetes mellitus that was not complicated by nephropathy, retinopathy or neuropathy. All common causes of muscle infarction were excluded, particularly microangiopathy and a hypercoagulable state. The differential diagnosis included infection (pyomyositis, necrotic fasciitis), focal inflammatory myositis, vascular events, trauma, tumor and diabetic amyotrophy, all of which were excluded. In spite of good glycaemic control, her diabetes remained brittle; alternating states of transient acute hypoglycaemia and hyperglycaemia may have been responsible for the infarction. Brittleness resumed after treatment with subcutaneous insulin infusion using a portable pump. No recurrence of muscle i... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1041656 Thu, 15 Nov 2007 05:00:00 +0100 1041656 http://www.medworm.com/index.php?rid=1033548&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18006351%26dopt%3DAbstract CONCLUSIONS: CKD prevalence is high in La Réunion island population, and the metabolic syndrome may help to target early diagnosis of CKD in non-diabetic individuals. PMID: 18006351 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1033548 Mon, 12 Nov 2007 05:00:00 +0100 1033548 http://www.medworm.com/index.php?rid=1022364&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17997340%26dopt%3DAbstract CONCLUSIONS: The impaired production of IL-1, IL-6, TNFalpha and IFNgamma, and the increased production of IL-10, in PBMC cultures from type 1 diabetics with inadequate metabolic control compared with healthy subjects may be an indication of a deficiency in mononuclear cell activation and, consequently, a deficient immune cellular adaptive response that, in turn, may be the cause of the increased incidence of infections in people with type 1 diabetes. PMID: 17997340 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1022364 Tue, 06 Nov 2007 05:00:00 +0100 1022364 http://www.medworm.com/index.php?rid=1022363&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17997341%26dopt%3DAbstract Authors: Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F In the light of recent studies in humans and rodents, AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase, has been described as an integrator of regulatory signals monitoring systemic and cellular energy status. AMP-activated protein kinase (AMPK) has been proposed to function as a 'fuel gauge' to monitor cellular energy status in response to nutritional environmental variations. Recently, it has been proposed that AMPK could provide a link in metabolic defects underlying progression to the metabolic syndrome. AMPK is a heterotrimeric enzyme complex consisting of a catalytic subunit alpha and two regulatory subunits beta and gamma. AMPK is activated by rising AMP and... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1022363 Tue, 06 Nov 2007 05:00:00 +0100 1022363 http://www.medworm.com/index.php?rid=1015860&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17988918%26dopt%3DAbstract This report summarizes the available data on this tool and details how best to use this state-of-the-art modality in diabetic patients in clinical practice. PMID: 17988918 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1015860 Mon, 05 Nov 2007 05:00:00 +0100 1015860 http://www.medworm.com/index.php?rid=1007454&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17981485%26dopt%3DAbstract Authors: Balkau B, Valensi P, Eschwège E, Slama G While the concept of this syndrome has been described more than 60 years ago, and more formally almost 20 years ago, the controversy continues as to its utility, which of the various syndrome definitions should be used and their ability to predict diabetes and/or cardiovascular disease. The metabolic syndrome, of cardiovascular risk factors, provides an early warning of at risk subjects and emphasises the need to treat more aggressively (by at least lifestyle modification) patients with multiple abnormalities even though the abnormalities might be slight. Further, the syndrome can be easily used in clinical practice and when it is assessed against the background of the patient's age, sex and smoking habits, it provides an evaluatio... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1007454 Fri, 02 Nov 2007 04:00:00 +0100 1007454 http://www.medworm.com/index.php?rid=1007455&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17977767%26dopt%3DAbstract CONCLUSIONS: Bioclinical first-line stratification allows identification of diabetic patients who have a good medium-term cardiac prognosis. The CE rate is similar in selected high-risk asymptomatic patients with diabetes using an intensive MPI-guided program that combines medical therapy, coronary angiography in the 16% of cases with severe ischemia and, if appropriate, revascularization. PMID: 17977767 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=1007455 Mon, 29 Oct 2007 04:00:00 +0100 1007455 http://www.medworm.com/index.php?rid=989836&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17964843%26dopt%3DAbstract CONCLUSIONS: The prevalence of celiac disease is higher in children with type 1 DM than in the general pediatric population. Serological screening is useful for diagnosing asymptomatic celiac disease, detecting seroconversion and monitoring latent forms of disease. PMID: 17964843 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=989836 Thu, 25 Oct 2007 04:00:00 +0100 989836 http://www.medworm.com/index.php?rid=954221&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17936663%26dopt%3DAbstract Authors: Bouhanick B, Chamontin B Patients with a blunted fall in nocturnal BP (known as non-dippers) have a high risk of micro- and macrovascular complications, particularly if they have hypertension, but also in normotensive patients with diabetes. A blunted fall in nocturnal BP reflects the high level of CV risk in these patients. ABPM data indicating an altered circadian BP rhythm reverse circadian BP profile should alert the physician to the potential risk of complications and should lead to efforts to treat hypertension effectively, especially at night, and to check for sleep apnoea syndrome, particularly in cases of resistant hypertension, or autonomic neuropathy (postural hypotension), a well known risk factor for cardiovascular (CV) events. Patients should be carefully screene... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=954221 Thu, 11 Oct 2007 04:00:00 +0100 954221 http://www.medworm.com/index.php?rid=954220&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17936664%26dopt%3DAbstract We report a very rapid and good efficacy of pioglitazone added to metformin without side effects in FPLD2. If confirmed on more patients, early use of pioglitazone in association with metformin could be proposed in FPLD2. PMID: 17936664 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=954220 Thu, 11 Oct 2007 04:00:00 +0100 954220 http://www.medworm.com/index.php?rid=954219&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17936665%26dopt%3DAbstract CONCLUSION: In very sedentary patients undergoing such tests for targeting exercise prescription, the 3-min procedure appears to be too short for performing an accurate calorimetry and we rather recommend the protocol using 6-min steps. PMID: 17936665 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=954219 Thu, 11 Oct 2007 04:00:00 +0100 954219 http://www.medworm.com/index.php?rid=948012&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17931948%26dopt%3DAbstract CONCLUSION: Although the observed association of SMAD7 and KLF10 gene variants with T2D is modest, they may weakly contribute to a particular genetic background that increases the susceptibility to development of T2D. PMID: 17931948 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=948012 Tue, 09 Oct 2007 04:00:00 +0100 948012 http://www.medworm.com/index.php?rid=945461&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17928252%26dopt%3DAbstract Authors: Sartorio A, Adorni F, Lafortuna CL PMID: 17928252 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=945461 Mon, 08 Oct 2007 04:00:00 +0100 945461 http://www.medworm.com/index.php?rid=936973&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17921019%26dopt%3DAbstract CONCLUSION: Our results do not support the hypothesis that dietary iron intake and body iron stores are deleterious to the structure and function of large arteries in subjects free of CVD, cancer or hemochromatosis. PMID: 17921019 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=936973 Fri, 05 Oct 2007 04:00:00 +0100 936973 http://www.medworm.com/index.php?rid=812071&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17703979%26dopt%3DAbstract Authors: Virally M, Blicklé JF, Girard J, Halimi S, Simon D, Guillausseau PJ In France, prevalence of drug-treated diabetes reached 3.60% in 2005, with 92% of type 2 diabetic patients. In 2007, there are probably nearly 3000 000 diagnosed or undiagnosed diabetic patients. Ageing of the population and increase in obesity are the main causes of this "diabetes epidemic". Type 2 diabetes is a multifactorial disease, defined as resulting from defects in insulin secretion (including abnormalities in pulsatility and kinetics, quantitative and qualitative abnormalities of insulin, beta-cell loss progressing with time) associated with insulin resistance (affecting liver, and skeletal muscle) and increased glucagon secretion. The lack of compensation of insulin resistance by augmented insulin s... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=812071 Fri, 17 Aug 2007 04:00:00 +0100 812071 http://www.medworm.com/index.php?rid=807468&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17702622%26dopt%3DAbstract Authors: Halimi JM, Hadjadj S, Aboyans V, Allaert FA, Artigou JY, Beaufils M, Berrut G, Fauvel JP, Gin H, Nitenberg A, Renversez JC, Rusch E, Valensi P, Cordonnier D Urinary albumin excretion (UAE) may be assayed on a morning urinary sample or a 24 h-urine sample. Values defining microalbuminuria are: 1) 24-h urine sample: 30-300 mg/24 h; 2) morning urine sample: 20-200 mg/ml or 30-300 mg/g creatinine or 2.5-25 mg/mmol creatinine (men) or 3.5-35 mg/mmol (women); 3) timed urine sample: 20-200 mug/min. The optimal use of semi-quantitative urine test-strip is not clearly defined. It is generally believed that microalbuminuria reflects a generalized impairment of the endothelium; however, no definite proof has been obtained in humans. IN DIABETIC SUBJECTS: Microalbuminuria is a marker of i... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=807468 Tue, 14 Aug 2007 04:00:00 +0100 807468 http://www.medworm.com/index.php?rid=761591&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17652001%26dopt%3DAbstract Authors: Virally M, Laloi-Michelin M, Meas T, Ciraru N, Ouled N, Médeau V, Kevorkian JP, Truc JB, Guillausseau PJ AIM: Among the numerous guidelines defining the diagnostic strategy of gestational diabetes mellitus (GDM), none of them suggest a follow-up in women with risk factors beyond the 28th week of gestation (WG). The primary objective of this study was to assess the incidence of GDM beyond 28 WG in a group of women at high risk. The secondary objectives were to evaluate maternal and fetal outcomes in early and late GDM (between 24-28 WG, and beyond 28 WG), as well as to compare them to a normal glucose tolerance (NGT) group. METHODS: A prospective study conducted in 191 consecutive women. Between 24-28 WG, the diagnosis of GDM was performed in a two-step approach (50 then 75 g)... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=761591 Mon, 23 Jul 2007 04:00:00 +0100 761591 http://www.medworm.com/index.php?rid=761590&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17652002%26dopt%3DAbstract CONCLUSION: In a general population of children, overweight and abdominal fat distribution were associated with increased GGT. As some studies have shown that GGT could predict the metabolic syndrome in children and type 2 diabetes in adults, the modest elevation of GGT observed in overweight children may be of pathophysiological importance in the long term. PMID: 17652002 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=761590 Mon, 23 Jul 2007 04:00:00 +0100 761590 http://www.medworm.com/index.php?rid=761589&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17652003%26dopt%3DAbstract CONCLUSION: NH were highly prevalent and often undetected. SMBG at bedtime, which detected hypoglycaemia had sensitivity almost equal to that of 3-hour and should be preferred because it is easier to perform. Somogyi phenomenon was not observed. CGMS is useful to reduce the risk of NH in 75% of patients. PMID: 17652003 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=761589 Mon, 23 Jul 2007 04:00:00 +0100 761589 http://www.medworm.com/index.php?rid=752994&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17644447%26dopt%3DAbstract We report the case of a patient suffering from type 1 diabetes who was found comatose with a plasma glucose close to zero after having injected herself massive doses of both aspart and glargine insulin analogues. The prevention of hypoglycaemic episodes in this patient required a long-term glucose infusion (i.e., 59 hours) which significantly exceeds the usual time-effect profile of glargine. This observation emphasizes again that clinicians should be aware of the extremely prolonged action of long acting insulin analogue glargine after intentional massive injection in order to avoid a too early interruption of glucose infusion and a subsequent risk of relapse of severe hypoglycaemic episodes. PMID: 17644447 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=752994 Tue, 17 Jul 2007 04:00:00 +0100 752994 http://www.medworm.com/index.php?rid=590747&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17475531%26dopt%3DAbstract CONCLUSION: Long-term combination therapy with OHA and CSII with only basic manipulation and optimization of insulin doses exerted on basal rate or on boluses is feasible, effective and well accepted in type 2 diabetes. PMID: 17475531 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=590747 Mon, 30 Apr 2007 04:00:00 +0100 590747 http://www.medworm.com/index.php?rid=590746&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17475532%26dopt%3DAbstract Authors: Migrenne S, Magnan C, Cruciani-Guglielmacci C Nutrient sensitive neurons (glucose and fatty acids, FA) are present in both the hypothalamus and the brainstem and play a key role in nervous control of energy homeostasis. Through neuronal output, especially the autonomic nervous system, it is now evidenced that FA may modulate food behaviour and both insulin secretion and action. For example, central administration of oleate inhibits both food intake and hepatic glucose production in rats. This suggests that a slight increase in plasma FA concentrations in the postprandial state might be detected by the central nervous system as a satiety signal. At cellular levels, subpopulations of FA-sensitive neurons (either excited or inhibited by FA) are now identified within the hypothala... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=590746 Mon, 30 Apr 2007 04:00:00 +0100 590746 http://www.medworm.com/index.php?rid=590745&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17475533%26dopt%3DAbstract Authors: Boizel R, Benhamou PY, Renard E, PMID: 17475533 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=590745 Mon, 30 Apr 2007 04:00:00 +0100 590745 http://www.medworm.com/index.php?rid=584020&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17466560%26dopt%3DAbstract Authors: Halbron M, Jacqueminet S, Sachon C, Bosquet F, Hartemann-Heurtier A, Grimaldi A It is logical to begin type 2 insulin therapy with an injection of an intermediate-acting or a long-acting insulin at bedtime, but one should treat to target, i.e. aim at fasting glycaemias lower than 1.20 g/l to obtain an HbA(1c) close to 7%. Nevertheless, basal insulin therapy does not prevent progression to insulin-secretory deficiency. If necessary, recourse should be made to multiple-injection protocols, taking into account postprandial hyperglycaemia. For every level of HbA(1c), the suppression of postprandial hyperglycaemia, 1 point of HbA(1c) can be gained in theory, whereas reducing the fasting glycaemia to values of less than 1.10 g/l reduces HbA(1c) to close to 7%, whatever the initial l... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=584020 Wed, 25 Apr 2007 04:00:00 +0100 584020 http://www.medworm.com/index.php?rid=570372&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296508%26dopt%3DAbstract Authors: Halimi S PMID: 17296508 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570372 Fri, 01 Dec 2006 05:00:00 +0100 570372 http://www.medworm.com/index.php?rid=570370&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296509%26dopt%3DAbstract Authors: Sultan A, Thuan JF, Avignon A The diagnosis of type 2 diabetes is based on elevated blood glucose levels. However, in most individuals, metabolic abnormalities as well as cardiovascular risk factors co-exist with a significant proportion of patients presenting with elevated blood pressure, high triglycerides and decreased HDL-cholesterol in addition to hyperglycemia. The risk of cardiovascular disease in people with type 2 diabetes is very high as cardiovascular death represents the number 1 killer in this population. An integrated approach controlling all risk factors as well as blood glucose has been demonstrated to effectively reduce the risk of cardiovascular complications. However, this requires the administration of multiple medications and some patients will have diffic... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570370 Fri, 01 Dec 2006 05:00:00 +0100 570370 http://www.medworm.com/index.php?rid=570368&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296510%26dopt%3DAbstract Authors: Flechtner I, de Lonlay P, Polak M ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir). Several isoforms exist for each type of subunits: SUR1 is found in the pancreatic beta-cell and neurons, whereas SUR2A is in heart cells and SUR2B in smooth muscle; Kir6.2 is in the majority of tissues as pancreatic beta-cells, brain, heart and skeletal muscle, and Kir6.1 can be found in smooth vascular muscle and astrocytes. The K(ATP) channels play multiple physiological roles in the glucose metabolism regulation, especially ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570368 Fri, 01 Dec 2006 05:00:00 +0100 570368 http://www.medworm.com/index.php?rid=570366&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296511%26dopt%3DAbstract CONCLUSION: Regular aerobic exercise has beneficial effects on glycaemic control, insulin resistance, cardiovascular risk, oxidative stress-defense parameters in overweight and obese type 2 diabetics. PMID: 17296511 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570366 Fri, 01 Dec 2006 05:00:00 +0100 570366 http://www.medworm.com/index.php?rid=570364&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296512%26dopt%3DAbstract CONCLUSION: This work has enabled the establishment of ketonemia reference standards in non-diabetic pregnant women. If ketonemia does indeed indicate overly restrictive dietary behavior, this parameter could be employed for monitoring adherence to the nutritional recommendations for GDM. PMID: 17296512 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570364 Fri, 01 Dec 2006 05:00:00 +0100 570364 http://www.medworm.com/index.php?rid=570362&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296513%26dopt%3DAbstract We describe a case of hypoglycaemia with high insulinemia in which insulinoma could not be evidenced. Surprisingly, we found in the patient's serum both insulin autoantibodies and insulin receptor autoantibodies. Available data eventually supported the predominant role of insulin autoantibodies rather than insulin receptor autoantibodies in the mechanism of hypoglycaemia of this patient. Insulin antibodies were present in high titre. Most of the insulin in serum was bound to the insulin antibodies and free insulin was slightly increased. HLA typing displayed DR4 haplotype, known to be strongly linked to the insulin autoimmune syndrome. The patient's serum was able to inhibit insulin binding to its receptor in a cultured cell line overexpressing insulin receptors both in experiments with na... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570362 Fri, 01 Dec 2006 05:00:00 +0100 570362 http://www.medworm.com/index.php?rid=570360&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296514%26dopt%3DAbstract CONCLUSIONS: Type 2 diabetes is associated with a decrease in lipid oxidation at exercise and a shift towards a predominance of carbohydrate oxidation for exercise intensities lower than in control subjects. Taking into account these alterations could provide a basis for personalizing training intensity. PMID: 17296514 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570360 Fri, 01 Dec 2006 05:00:00 +0100 570360 http://www.medworm.com/index.php?rid=570357&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296515%26dopt%3DAbstract Authors: Bezie Y, Molina M, Hernandez N, Batista R, Niang S, Huet D It's established that adherence rates to treatment are bad in chronic illnesses. The number of medicines prescribed and the rates of daily dosages have been shown to be of major influence for therapeutic compliance in AIDS or hypertension. Nevertheless, data on adherence to prescribed medications amongst diabetics are scarce. The aim of our study was to evaluate parameters influencing therapeutic compliance in type 2 diabetes. Adherence to treatment was evaluated by a questionnaire filled out during patient's hospitalisation in the diabetology department of a French general hospital of 450 beds. Factors influencing compliance were quantified taking into account demographic characteristics of our population, the treatme... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570357 Fri, 01 Dec 2006 05:00:00 +0100 570357 http://www.medworm.com/index.php?rid=570354&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296516%26dopt%3DAbstract CONCLUSION: Ramadan fasting increases the lipid oxidation of trained athletes during submaximal exercise. The increased fat utilisation may be related to decreases in body mass and body fat content. PMID: 17296516 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570354 Fri, 01 Dec 2006 05:00:00 +0100 570354 http://www.medworm.com/index.php?rid=570351&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296517%26dopt%3DAbstract CONCLUSIONS: In the present study we demonstrate for the first time a lowering effect of insulin therapy on oxidized LDL/LDL-C ratio in type 2 diabetic patients. This decrease is mainly associated with the reduction of LDL TG-enrichment, and to a lesser extent with the decrease of LDL glycation, but not with the insulin-induced increase in number of LDL receptors. PMID: 17296517 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570351 Fri, 01 Dec 2006 05:00:00 +0100 570351 http://www.medworm.com/index.php?rid=570348&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296518%26dopt%3DAbstract CONCLUSIONS: Our results demonstrate that clinical symptoms and acute ketosis are the most common presenting features of diabetes mellitus in adults at the hospital level. Associated chronic complications are frequent. PMID: 17296518 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570348 Fri, 01 Dec 2006 05:00:00 +0100 570348 http://www.medworm.com/index.php?rid=570344&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296519%26dopt%3DAbstract Authors: Le Pommelet C, Le Moullec N, Zunic P The discovery of an haemolytic anemia after a diabetic ketoacidosis led us to diagnose glucose-6-phosphate dehydrogenase (G6PD) deficiency in a 38-year old male patient. After a favorable course, we reviewed the links between this genetically transmitted enzymatic defect and diabetes mellitus, a public health concern in La Réunion. This description is a rare case of G6PD deficiency revealed after diabetic ketoacidosis in an adult. PMID: 17296519 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570344 Fri, 01 Dec 2006 05:00:00 +0100 570344 http://www.medworm.com/index.php?rid=570340&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296520%26dopt%3DAbstract CONCLUSION: Our review suggests that a one-time carotid ultrasonography screening could be recommended for diabetic patients with coronary disease or lower limb atherosclerosis (secondary prevention), all diabetic patients above 60 years of age, smokers, hypertensive and with hypercholesterolemia; type 1 diabetic patients with poor long term glycaemic control; all type 2 diabetic patients with renal failure, a long duration of ill-controlled diabetes or with a carotid bruit. This literature review should be analyzed with caution. It would be helpful to organize a prospective long term study on all types of diabetic patients, including a carotid ultrasonography screening program by experienced radiologists. PMID: 17296520 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570340 Fri, 01 Dec 2006 05:00:00 +0100 570340 http://www.medworm.com/index.php?rid=570338&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17312575%26dopt%3DAbstract Authors: PMID: 17312575 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570338 Fri, 01 Dec 2006 05:00:00 +0100 570338 http://www.medworm.com/index.php?rid=570379&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17110900%26dopt%3DAbstract CONCLUSION: Our results suggest that in diabetic subjects osteopenia is a relatively frequent complication but bone loss is attenuated with age progression. Whether this is also mediated by OPG and/or leptin remains to be confirmed. PMID: 17110900 [PubMed - indexed for MEDLINE] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570379 Wed, 01 Nov 2006 05:00:00 +0100 570379 http://www.medworm.com/index.php?rid=570332&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375400%26dopt%3DAbstract Authors: Balkau B, Eschwège E There are few studies on the effects of postprandial hyperglycaemia, and usually it is assumed that its effects are the same as those of post-glucose-load hyperglycaemia, following a standard 75 g oral glucose tolerance test. There is some evidence from a study with blood drawn following ingestion of a standardised "diabetes screening product" or a 75 g oral glucose load, that the glucose concentrations during the 2-hour period of these two tests are highly correlated. There is epidemiological evidence that the 2-hour post-load-glucose is more predictive of cardiovascular mortality than fasting glucose, but it would appear that they are equally predictive of retinopathy. While hyperglycaemia is related with cardiovascular mortality, clinical trials loweri... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570332 Fri, 01 Sep 2006 04:00:00 +0100 570332 http://www.medworm.com/index.php?rid=570330&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375401%26dopt%3DAbstract Authors: Monnier L, Colette C, Boniface H Even though fasting and postprandial glucose are both contributors to the overall hyperglycaemia as observed in patients with type 2 diabetes, their respective contributions are varying with the degree of diabetic control. The contribution of postprandial glucose is predominant in patients with satisfactory control of diabetes (HbAlc < 7.3%) whereas the contribution of fasting glucose increases progressively with worsening diabetes. As a consequence an overall picture of the diabetic control should normally be based on the assessment of the "glucose triad" with its three components: HbAlc which integrates the diabetic control over a 3-month period, fasting and postprandial glucose. The two later are good indicators of the glycaemic regulatio... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570330 Fri, 01 Sep 2006 04:00:00 +0100 570330 http://www.medworm.com/index.php?rid=570328&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375402%26dopt%3DAbstract Authors: Le Dévéhat C Self-monitoring of blood glucose (SMBG) in management of type 2 diabetes mellitus continues to be debated. However, SMBG is recognized as being useful (professional agreement) in three situations: sensitizing the type 2 diabetic patient to the advantages of diet control and physical exercise, determining and adapting the dosage of oral antidiabetic medication at the beginning of treatment or during a dosage change, and monitoring plasma glucose during intercurrent disease or during a treatment that may lead to acute blood glucose imbalance. However, the frequency, the timing of blood glucose monitoring, and the target blood glucose values remain poorly defined. It is well known that the postprandial period covers approximately 50% of the day, and several recent ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570328 Fri, 01 Sep 2006 04:00:00 +0100 570328 http://www.medworm.com/index.php?rid=570326&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375403%26dopt%3DAbstract Authors: Charpentier G, Dardari D, Riveline JP In an attempt to prevent the complications of type 2 diabetes, particular attention should be paid to controlling postprandial glycemia (PPG): on the one hand, it contributes substantially to the HbAlc level in moderately controlled patients, on the other hand, the postprandial glucose peak induces oxidative stress and endothelial dysfunction, the first step toward accelerated atherogenesis. Metformin, glitazones, and insulin secretagogues have an additive effect on fasting blood glucose (FBG), and a significant impact on PPG. Alpha-glucosidase inhibitors can reduce PPG by a mean 0.50 g/l, no matter what the insulin resistance or insulinopenia status or the other diabetes treatments already in use. After evolving for several years and the ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570326 Fri, 01 Sep 2006 04:00:00 +0100 570326 http://www.medworm.com/index.php?rid=570324&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375404%26dopt%3DAbstract Authors: Nitenberg A, Cosson E, Pham I Endothelium plays a key role in the regulation of vascular tone and development of atherosclerosis. Endothelial function is impaired early in patients with risk factors and endothelial dysfunction is a strong and independent predictor of cardiovascular events. Because in normal subjects blood concentrations of glucose, lipids and insulin are increased after each meals, and postprandial changes last a long time after the meals, these changes might be of importance in the process of atherosclerosis initiation and development. Experimental and human studies have shown that a transient increase of blood concentrations of glucose, triglycerides and fatty acids, and insulin are able to depress endothelium-dependent vasodilation in healthy subjects and t... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570324 Fri, 01 Sep 2006 04:00:00 +0100 570324 http://www.medworm.com/index.php?rid=570322&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375405%26dopt%3DAbstract Authors: Wautier JL, Boulanger E, Wautier MP Glucose or glucose derived products are increased in blood during the postprandial phase and are, to a certain extent, related to meal composition. Glucose and glucose derived products such as advanced glycation end products (AGEs) can be formed in the intracellular compartment but can also be absorbed as AGEs or AGE precursors present in food. Glucose, glucose metabolites and AGEs alter endothelial cell functions, induce adhesion molecule overexpression (ICAM-1, VCAM), cytokine release (IL-6, MCP-1) and tissue factor production. Tumor necrosis factor alpha systemic level is increased during the postprandial phase as are augmented C reactive protein and fibrinogen level. Hyperglycemia induced an increase in plasminogen activator inhibitor, a... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570322 Fri, 01 Sep 2006 04:00:00 +0100 570322 http://www.medworm.com/index.php?rid=570320&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375406%26dopt%3DAbstract Authors: Valensi P, Cosson E Several experimental data suggest that single sugar intake may induce heart rate acceleration and blood pressure elevation as a result of sympathetic activation secondary to insulin response and from alterations in endothelial function due to activation of oxidative stress. These hemodynamic effects might be more marked in patients with arterial hypertension or metabolic disorders, in particular in hypertensive patients with diabetes. A high-fat load may also induce activation of oxidative stress and endothelial dysfunction. However, the long-term effect of repeated intake of single sugar and fat on blood pressure, oxidative stress, and endothelial function should be tested in controlled trials. On the contrary, a balanced mixed meal (50% carbohydrates) doe... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570320 Fri, 01 Sep 2006 04:00:00 +0100 570320 http://www.medworm.com/index.php?rid=570318&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375407%26dopt%3DAbstract Authors: Zeller M, Vergès B, L'Huillier I, Brun JM, Cottin Y Diabetes is an established major factor of poor prognostis after an acute coronary syndrome. Recent studies have addressed the impact of abnormal glucose metabolism at the acute phase in patients without known diabetes. It has been found that abnormal glycemia regulation is more common than normal regulation in patients presenting with acute coronary syndrome, whatever the method used to evaluate blood glucose metabolism. High blood glucose at admission, whether fasting or not, are associated with worse outcome after an acute coronary syndrome, ie. by increased mortality and development of severe heart failure. The prognosistic value of glycemia is valuable for both short and long term outcomes. Admission glycemia measuremen... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570318 Fri, 01 Sep 2006 04:00:00 +0100 570318 http://www.medworm.com/index.php?rid=570315&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17375408%26dopt%3DAbstract Authors: Raccah D The problem of blood glucose as a cardiovascular risk factor has long been debated. Indeed, increasing arguments confirm the importance of blood glucose on cardiovascular risk, as shown by the results from epidemiological studies and therapeutic investigations. However, the literature has demonstrated the importance of postprandial blood glucose, or post-load-glucose, on cardiovascular risk. One could think that blood glucose, in particular postprandial blood glucose, is an independent, although not major, cardiovascular risk factor compared to other classical risk factors such as hypercholesterolemia, high blood pressure, and smoking, but it potentiates the risk when it coexists with these classical risk factors. This explains the increased prevalence of cardiovascul... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=570315 Fri, 01 Sep 2006 04:00:00 +0100 570315