MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diabetes and Metabolism' source. Wed, 08 Feb 2012 15:08:52 +0100 http://www.medworm.com/index.php?rid=5662645&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22300975%26dopt%3DAbstract CONCLUSION: Performing OGTT in obese women selected on a simple clinical score is more sensitive to identify dysglycaemia than measuring FPG in all of them and may be cost-effective. PMID: 22300975 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5662645 Tue, 31 Jan 2012 05:00:00 +0100 5662645 http://www.medworm.com/index.php?rid=5662646&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22284547%26dopt%3DAbstract CONCLUSION: Implant surgery is never a matter of urgency; thus, diabetes patients with the best chances of success should be conjointly selected and prepared by both dental and diabetes clinicians. PMID: 22284547 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5662646 Wed, 25 Jan 2012 05:00:00 +0100 5662646 http://www.medworm.com/index.php?rid=5625911&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252014%26dopt%3DAbstract CONCLUSION: In recent years, considerable improvement has been observed in France regarding the follow-up of diabetic patients. Less extensive, but nonetheless significant, improvement has also been observed in glycaemic control. However, even though treatment decisions generally take renal function into account, some at-risk treatments are often still being used in patients with renal insufficiency. PMID: 22252014 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5625911 Sun, 15 Jan 2012 05:00:00 +0100 5625911 http://www.medworm.com/index.php?rid=5625910&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252015%26dopt%3DAbstract Authors: Calle MC, Fernandez ML Abstract Low-grade inflammation is a common feature in subjects with type 2 diabetes (T2D). Heart disease, the metabolic syndrome and T2D all have in common the increased concentration of circulatory cytokines as a result of inflammation. Inflammatory cytokines are produced by different cell types and secreted into the circulation, where they regulate different tissues through their local, central and peripheral actions. This review focuses on C-reactive protein (CRP), a well-established marker of the development of inflammation, on tumour necrosis factor (TNF)-α, an inflammatory marker strongly associated with diabetes, and on adiponectin, a cytokine produced by adipose tissue and associated with insulin sensitivity. While it is clear from the lite... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5625910 Sun, 15 Jan 2012 05:00:00 +0100 5625910 http://www.medworm.com/index.php?rid=5580014&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227407%26dopt%3DAbstract CONCLUSION: There was a major and rapid improvement in psoriasis in our patient with T2D following treatment with exenatide. A possible mechanism might be through direct modulation of the immune system by GLP-1 receptor agonists. PMID: 22227407 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580014 Fri, 06 Jan 2012 05:00:00 +0100 5580014 http://www.medworm.com/index.php?rid=5566757&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22209680%26dopt%3DAbstract Authors: Vergès B, Avignon A, Bonnet F, Catargi B, Cattan S, Cosson E, Ducrocq G, Elbaz M, Fredenrich A, Gourdy P, Henry P, Lairez O, Leguerrier AM, Monpère C, Moulin P, Vergès-Patois B, Roussel R, Steg G, Valensi P, Abstract The Diabetes and Cardiovascular Disease study group of the Société francophone du diabète (SFD, French Society of Diabetes) in collaboration with the Société française de cardiologie (SFC, French Society of Cardiology) have devised a consensus statement on the care of the hyperglycaemic/diabetic patient during and in the immediate follow-up of acute coronary syndrome (ACS); in particular, it includes the different phases of ACS [the intensive care unit (ICU) period, the post-ICU period and the short-term follow-up period after discharge, including ca... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5566757 Fri, 30 Dec 2011 05:00:00 +0100 5566757 http://www.medworm.com/index.php?rid=5552239&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22197148%26dopt%3DAbstract Authors: Scheen AJ Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors offer new options for the management of type 2 diabetes. Direct comparisons with active glucose-lowering comparators in drug-naive patients have demonstrated that DPP-4 inhibitors exert slightly less pronounced HbA(1c) reduction than metformin (with the advantage of better gastrointestinal tolerability) and similar glucose-lowering effects as with a thiazolidinedione (TZD; with the advantage of no weight gain). In metformin-treated patients, gliptins were associated with similar HbA(1c) reductions compared with a sulphonylurea (SU; with the advantage of no weight gain, considerably fewer hypoglycaemic episodes and no need for titration) and a TZD (with the advantage of no weight gain and better overall tolerabili... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5552239 Wed, 21 Dec 2011 05:00:00 +0100 5552239 http://www.medworm.com/index.php?rid=5537545&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22192621%26dopt%3DAbstract CONCLUSION: The BAPAD-1 scale is a reliable and valid tool for assessing salient barriers to physical activity. In future, this scale could be used to describe the factors accounting for physical activity, and for planning interventions aimed at promoting physical activity among adults with type 1 diabetes. PMID: 22192621 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5537545 Tue, 20 Dec 2011 05:00:00 +0100 5537545 http://www.medworm.com/index.php?rid=5537547&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22172400%26dopt%3DAbstract CONCLUSION: Considerable heterogeneity is found in insulin treatment regimens used in everyday diabetes care. Payers should consider the full costs associated with the use of insulin rather than the cost of insulin alone. Treatment algorithms to harmonize insulin therapy should help to improve care, while encouraging patients to self-inject insulin should help to reduce costs. PMID: 22172400 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5537547 Tue, 13 Dec 2011 05:00:00 +0100 5537547 http://www.medworm.com/index.php?rid=5537546&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22172401%26dopt%3DAbstract CONCLUSION: In this diabetic population, deprivation and glycaemic control were not associated. However, more deprived subjects with diabetes were at higher risk of renal disease. A deprived state was related to an altered quality of life as assessed by the SF-36 score. PMID: 22172401 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5537546 Tue, 13 Dec 2011 05:00:00 +0100 5537546 http://www.medworm.com/index.php?rid=5426756&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22078638%26dopt%3DAbstract CONCLUSION: Spanish women with diabetes consistently underuse breast and cervical cancer screening tests compared with non-diabetic women. The decline in mammography uptake rates needs to be carefully monitored and may even call for intervention. PMID: 22078638 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5426756 Wed, 09 Nov 2011 05:00:00 +0100 5426756 http://www.medworm.com/index.php?rid=5426757&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074636%26dopt%3DAbstract Authors: Désidéri-Vaillant C, Nédelec Y, Guichon JM, Le Louarn S, Noyer V, Sapin-Lory J, Le Guen P, Nicolas X Abstract Staphylococcus simulans was identified as the aetiological agent of osteitis in a diabetic woman. Its identifying characteristics and antibiogram were confirmed. Diabetic foot frequently becomes infected and the spread of infection to bone is a major causal factor behind lower-limb amputation. Early diagnosis and appropriate treatment are essential in such cases. PMID: 22074636 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5426757 Tue, 08 Nov 2011 05:00:00 +0100 5426757 http://www.medworm.com/index.php?rid=5426759&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22071281%26dopt%3DAbstract CONCLUSION: The MetS is associated with the incidence of diabetes, and the synergy between the MetS and diabetes is an important risk factor for all-cause mortality in elderly subjects. PMID: 22071281 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5426759 Mon, 07 Nov 2011 05:00:00 +0100 5426759 http://www.medworm.com/index.php?rid=5426758&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22071282%26dopt%3DAbstract Authors: Philips JC, Marchand M, Scheen AJ Abstract Cardiovascular autonomic neuropathy (CAN) is a frequent complication of diabetes mellitus, which is associated with increased morbidity and mortality. It involves both the parasympathetic and sympathetic nervous systems, and may be diagnosed by classical dynamic tests with measurements of heart rate (HR) and/or arterial blood pressure (BP). An original squat test (1-min standing, 1-min squatting, 1-min standing) was used with continuous monitoring of HR and BP, using a Finapres(®) device. This active test imposes greater postural stress than the passive head-up tilt test, and provokes large changes in BP and HR that can be analyzed to derive indices of CAN. In healthy subjects, squatting is associated with BP increases and HR dec... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5426758 Mon, 07 Nov 2011 05:00:00 +0100 5426758 http://www.medworm.com/index.php?rid=5426760&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22056307%26dopt%3DAbstract CONCLUSION: The aetiology of diabetic ED is multifactorial. Endothelial dysfunction is the link between diabetes-induced ED and coronary artery disease. A global approach is needed for the successful management of diabetic ED. PMID: 22056307 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5426760 Thu, 03 Nov 2011 04:00:00 +0100 5426760 http://www.medworm.com/index.php?rid=5382736&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030239%26dopt%3DAbstract Authors: Disse E, Rabasa-Lhoret R, Laville M, Bastard JP PMID: 22030239 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5382736 Mon, 24 Oct 2011 04:00:00 +0100 5382736 http://www.medworm.com/index.php?rid=5382735&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030240%26dopt%3DAbstract CONCLUSION: In this study of adults with T2D, patients significantly improved their metabolic control, and dietary and exercise habits, 1year after receiving intensive inpatients education, whereas subsequent quarterly outpatients counseling visits with nurses and dietitians have not demonstrated any superiority compared with the usual care. PMID: 22030240 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5382735 Mon, 24 Oct 2011 04:00:00 +0100 5382735 http://www.medworm.com/index.php?rid=5382734&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030241%26dopt%3DAbstract CONCLUSION: The use of RR E/I ratios to separate T1DM patients allows the detection of other CAN markers during an orthostatic posture test, but with no significant differences in pulsatile stress or microalbuminuria. In this context, squatting-derived baroreflex gain appears to be more informative. PMID: 22030241 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5382734 Mon, 24 Oct 2011 04:00:00 +0100 5382734 http://www.medworm.com/index.php?rid=5382733&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030242%26dopt%3DAbstract CONCLUSION: In this very elderly population, although marginally significant on crude analysis, PWV, but not systolic or pulse pressure, was a powerful determinant of total mortality after taking into account the important role of type 2 diabetes. In diabetics, inflammation and denutrition predominated over mechanical factors. PMID: 22030242 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5382733 Mon, 24 Oct 2011 04:00:00 +0100 5382733 http://www.medworm.com/index.php?rid=5382737&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22019715%26dopt%3DAbstract CONCLUSION: Diabetes education is an efficient tool for improving care outcomes without having a major impact on healthcare costs. PMID: 22019715 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5382737 Fri, 21 Oct 2011 04:00:00 +0100 5382737 http://www.medworm.com/index.php?rid=5316302&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996253%26dopt%3DAbstract CONCLUSION: In T2DM patients, serum osteocalcin levels were associated with parameters of atherosclerosis, suggesting that osteocalcin is involved not only in bone metabolism, but also in atherosclerotic disease. PMID: 21996253 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5316302 Tue, 11 Oct 2011 04:00:00 +0100 5316302 http://www.medworm.com/index.php?rid=5283271&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21963427%26dopt%3DAbstract CONCLUSION: Overweight and obese women have an increased risk rate of macrosomia that can be limited by well-controlled weight gain during pregnancy. There was also a significantly higher rate of surgical delivery in the obese compared with the normal weight group that was, however, independent of excessive weight gain during pregnancy. PMID: 21963427 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5283271 Thu, 29 Sep 2011 04:00:00 +0100 5283271 http://www.medworm.com/index.php?rid=5283278&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21944864%26dopt%3DAbstract CONCLUSION: Our data show that, to assess the crossover point and LIPOX(max) values for research purposes, the protocol must be based on the measured MAP rather than on a theoretical value. Such a determination should improve individualization of training for initially sedentary subjects. PMID: 21944864 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5283278 Fri, 23 Sep 2011 04:00:00 +0100 5283278 http://www.medworm.com/index.php?rid=5234698&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21925915%26dopt%3DAbstract CONCLUSION: This study suggests a potential role of insulin in regulating leptin levels in adults with stable CF. PMID: 21925915 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5234698 Fri, 16 Sep 2011 04:00:00 +0100 5234698 http://www.medworm.com/index.php?rid=5234699&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21917496%26dopt%3DAbstract CONCLUSION: Hand changes are more prevalent and severe in patients with T2DM, and are correlated with age, duration of diabetes and microvascular complications. PMID: 21917496 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5234699 Mon, 12 Sep 2011 04:00:00 +0100 5234699 http://www.medworm.com/index.php?rid=5221225&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21900030%26dopt%3DAbstract CONCLUSION: Offering additional group-based intervention to a high-risk population subgroup had no clinical effects on changes in plasma glucose beyond those of individualized multifactorial interventions. PMID: 21900030 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5221225 Mon, 05 Sep 2011 04:00:00 +0100 5221225 http://www.medworm.com/index.php?rid=5221226&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21889388%26dopt%3DAbstract Authors: Franc S, Daoudi A, Mounier S, Boucherie B, Dardari D, Laroye H, Neraud B, Requeda E, Canipel L, Charpentier G Abstract Health authorities currently have high expectations for telemedicine (TM), as it addresses several major challenges: to improve access to healthcare (especially for patients in underserved or remote areas); to overcome the scarcity of specialists faced with epidemic disease; and to reduce the costs of healthcare while improving quality. The aims of TM in the field of diabetes differ according to the type of diabetes. In type 1 diabetes (T1DM) associated with complex insulin regimens, the goal of TM is to help patients achieve better control of their blood glucose levels through accurate adjustment of insulin doses. In type 2 diabetes (T2DM), while therapeu... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5221226 Wed, 31 Aug 2011 04:00:00 +0100 5221226 http://www.medworm.com/index.php?rid=5180154&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21871831%26dopt%3DAbstract CONCLUSION: These compounds may play an important role in the treatment of patients with T2DM as their potential effects go beyond glucose-lowering (weight loss, potential improvement of cardiovascular risk factors). However, to better understand their place in the management of T2DM, further experimental and clinical prospective studies are required. PMID: 21871831 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5180154 Tue, 23 Aug 2011 23:00:00 +0100 5180154 http://www.medworm.com/index.php?rid=5180155&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868273%26dopt%3DAbstract CONCLUSION: Both raised FPG and decreased HRR are independent predictors of total and cardiovascular (CV) mortality in subjects with CHD. Our data suggest that the mortality risk associated with elevated FPG may in part be due to deleterious effects on autonomic regulation of CV function, as reflected by lower HRR. Further studies are required to determine whether or not non-pharmacological and/or pharmacological treatments of increased fasting glucose have a beneficial influence on HRR. PMID: 21868273 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5180155 Mon, 22 Aug 2011 23:00:00 +0100 5180155 http://www.medworm.com/index.php?rid=5160154&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21865069%26dopt%3DAbstract CONCLUSION: These data suggest that the lack of glucose-stimulated ATBF is associated with resistance to sympathetic activation in adipose tissue. PMID: 21865069 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5160154 Sun, 21 Aug 2011 23:00:00 +0100 5160154 http://www.medworm.com/index.php?rid=5108425&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21820345%26dopt%3DAbstract Authors: Hartemann A, Attal N, Bouhassira D, Dumont I, Gin H, Jeanne S, Said G, Richard JL, The prevalence of painful diabetic peripheral neuropathy (PDN) is about 20% in patients with type 2 diabetes and 5% in those with type 1. Patients should be systematically questioned concerning suggestive symptoms, as they are not usually volunteers. As PDN is due to small-fibre injury, the 10g monofilament pressure test as well as the standard electrophysiological procedures may be normal. Diagnosis is based on clinical findings: type of pain (burning discomfort, electric shock-like sensation, aching coldness in the lower limbs); time of occurrence (mostly at rest and at night); and abnormal sensations (such as tingling or numbness). The DN4 questionnaire is an easy-to-use validated diagnostic... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5108425 Tue, 02 Aug 2011 23:00:00 +0100 5108425 http://www.medworm.com/index.php?rid=5108426&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21802332%26dopt%3DAbstract CONCLUSION: Prolonged fasting is possible at home in patients with type 1 diabetes, provided the basal dose is adjusted. The use of CGMS is not necessary, but offers useful information on the patient's IG profile during the fast. PMID: 21802332 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5108426 Tue, 26 Jul 2011 23:00:00 +0100 5108426 http://www.medworm.com/index.php?rid=5108427&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21778101%26dopt%3DAbstract Authors: Soggia A, Hoarau E, Bechetoille C, Simon MT, Heinis M, Duvillié B Diabetes affects 246 million people around the world. To date, no definitive cure has been discovered. Recent clinical trials have shed light on the possibility of successfully transplanting adult pancreatic islets into type 1 diabetic recipients. However, despite encouraging efforts to improve such protocols, the poor availability of pancreatic islets remains a limiting parameter for these transplantation programmes. In the present review, different strategies to obtain other sources of islet beta cells are discussed. PMID: 21778101 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5108427 Mon, 18 Jul 2011 23:00:00 +0100 5108427 http://www.medworm.com/index.php?rid=5108429&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21764347%26dopt%3DAbstract CONCLUSION: The prevalence of SMI in our Afro-Caribbean diabetic population was 23.1%. Searching for a personal history of cardiovascular disease and LVH may help to identify patients who need to be screened for SMI. PMID: 21764347 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5108429 Thu, 14 Jul 2011 23:00:00 +0100 5108429 http://www.medworm.com/index.php?rid=5108428&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21764620%26dopt%3DAbstract CONCLUSION: The rate of vitamin D deficiency was high in our T2D patients, and was associated with the VDR gene FokI and ApaI polymorphisms and cardiovascular risk profile. Measurements of vitamin D may help to detect T2D patients with cardiovascular risk, and VDR polymorphisms might explain why vitamin D deficiency is so frequently seen in some T2D patients. PMID: 21764620 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5108428 Wed, 13 Jul 2011 23:00:00 +0100 5108428 http://www.medworm.com/index.php?rid=5108430&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21757386%26dopt%3DAbstract CONCLUSION: IPT resulted in greater improvement of gingival health in patients with DM. Improved oral health in those with type 2 DM may have an effect on medium-term glucose management and could possibly lead to long-term health benefits. (ISRCTN00559156). PMID: 21757386 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5108430 Mon, 11 Jul 2011 23:00:00 +0100 5108430 http://www.medworm.com/index.php?rid=5012172&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21723177%26dopt%3DAbstract CONCLUSION: The POMC SNP haplotype GGCGAG may have a protective effect against T1D in the UK population. However, this finding needs to be replicated, and the cellular and molecular processes influenced by this POMC haplotype determined to fully appreciate its impact. PMID: 21723177 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5012172 Tue, 28 Jun 2011 23:00:00 +0100 5012172 http://www.medworm.com/index.php?rid=5012173&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21715211%26dopt%3DAbstract CONCLUSION: Sudoscan™ is a reproducible technique with results that are not influenced by blood glucose levels. Sweating status may be a quantitative indicator of the severity of polyneuropathy that may be useful for the early prevention of foot skin lesions. PMID: 21715211 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=5012173 Sun, 26 Jun 2011 23:00:00 +0100 5012173 http://www.medworm.com/index.php?rid=4969130&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21684789%26dopt%3DAbstract CONCLUSION: Fulminant type 1 diabetes mellitus is a recently described presentation of diabetes mellitus that has been predominately reported in Japan and other Asian countries. The classical presentation includes rapid onset on ketosis within 1week of symptoms of hyperglycaemia, with a near-normal glycohaemoglobin and absence of C-peptide. With the majority of case being reported from Asia, it has been hypothesized that there is a genetic determent that predisposes Asian individuals to develop fulminant type 1 diabetes mellitus. The addition of the case to the medical literature expands the focus of fulminant type 1 diabetes mellitus beyond the Asian population and supports the need that further research. PMID: 21684789 [PubMed - as supplied by publisher] (Source: Diabetes and Metabol... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4969130 Thu, 16 Jun 2011 23:00:00 +0100 4969130 http://www.medworm.com/index.php?rid=4969131&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21683639%26dopt%3DAbstract CONCLUSION: There was an HNF1A-MODY pick-up rate of 30.5% and an HNF4A-MODY pick-up rate of 6% in Irish MODY families. Genetically confirmed MODY has significant therapeutic implications. PMID: 21683639 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4969131 Tue, 14 Jun 2011 23:00:00 +0100 4969131 http://www.medworm.com/index.php?rid=4969133&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21680218%26dopt%3DAbstract Authors: Rigalleau V, Beauvieux MC, Gonzalez C, Raffaitin C, Lasseur C, Combe C, Chauveau P, De la Faille R, Rigothier C, Barthe N, Gin H Diabetes is the leading cause of chronic kidney disease (CKD), which makes estimation of renal function crucial. Serum creatinine is not an ideal marker of glomerular filtration rate (GFR), which also depends on digestive absorption, and the production of creatinine in muscle and its tubular secretion. Formulas have been devised to estimate GFR from serum creatinine but, given the wide range of GFR, proteinuria, body mass index and specific influence of glycaemia on GFR, the uncertainty of these estimations is a particular concern for patients with diabetes. The most popular recommended formulas are the simple Cockcroft-Gault equation, which is inacc... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4969133 Mon, 13 Jun 2011 23:00:00 +0100 4969133 http://www.medworm.com/index.php?rid=4969132&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21680219%26dopt%3DAbstract CONCLUSIONS: The number of children a person has is associated with changes in metabolic health indices long after childbirth for both men and women. The distinct gender differences in deterioration of metabolic health indices emphasize that childbearing and child-rearing are likely to have differential influences on metabolic health. PMID: 21680219 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4969132 Mon, 13 Jun 2011 23:00:00 +0100 4969132 http://www.medworm.com/index.php?rid=4969134&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21676638%26dopt%3DAbstract Authors: Ritz P, Hanaire H Gastric bypass is one of the most efficient strategies for long-term weight loss and reduction of the comorbidities associated with morbid obesity. Of the complications secondary to gastric bypass, hypoglycaemic episodes have so far been poorly studied. The present study is a comprehensive report of the fewer than 100 cases described in the literature. It shows that strict diagnostic criteria should be applied to differentiate true intense neuroglucopenic symptoms associated with low glucose values (<2.8 mmol/L) from the more frequent symptoms of the dumping syndrome and those occurring in the context of lower-than-normal plasma glucose concentrations. The pancreatic beta-cell hyperfunction initially deemed responsible for hypoglycaemic episodes because ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4969134 Sun, 12 Jun 2011 23:00:00 +0100 4969134 http://www.medworm.com/index.php?rid=4969135&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21665509%26dopt%3DAbstract CONCLUSION: These findings provide evidence that the PNPLA3 SNP rs738409 contributes to risk for increased liver fat content in African Americans with T2DM, an effect that appears to be independent from serum lipids. Although African Americans are less susceptible to fatty liver than European Americans, PNPLA3 appears to be a risk locus for hepatic steatosis in diabetic African Americans. PMID: 21665509 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4969135 Thu, 09 Jun 2011 23:00:00 +0100 4969135 http://www.medworm.com/index.php?rid=4969136&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21664164%26dopt%3DAbstract CONCLUSION: Abdominal subcutaneous fat cells from T2DM patients display signs of insulin resistance and microinflammatory status. NF-κB decoy molecules inhibited NF-κB overactivation and also partly reversed insulin resistance. These results provide evidence of a link between inflammation and insulin resistance in T2DM cells, suggesting a potential contribution of inflammation to the mechanism of insulin resistance. PMID: 21664164 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4969136 Tue, 07 Jun 2011 23:00:00 +0100 4969136 http://www.medworm.com/index.php?rid=4922363&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21636306%26dopt%3DAbstract CONCLUSION: These results suggest that PEDF abrogates AGE-induced oxidative stress and apoptosis in retinal pericytes via the Src pathway, thereby suggesting that PEDF is an effective therapeutic agent for the treatment of loss of pericytes in early diabetic retinopathy. PMID: 21636306 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4922363 Mon, 30 May 2011 23:00:00 +0100 4922363 http://www.medworm.com/index.php?rid=4876581&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21612964%26dopt%3DAbstract Authors: Menard J PMID: 21612964 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4876581 Sun, 22 May 2011 23:00:00 +0100 4876581 http://www.medworm.com/index.php?rid=4876582&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21596605%26dopt%3DAbstract CONCLUSION: The absence of an association between allostatic load and SRH in diabetic individuals contrasts with previous findings in non-diabetic women, and shows that it is hazardous to apply findings in one population to another, especially diabetic and non-diabetic populations. PMID: 21596605 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4876582 Mon, 16 May 2011 23:00:00 +0100 4876582 http://www.medworm.com/index.php?rid=4823666&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21550831%26dopt%3DAbstract CONCLUSION: An impatient relationship to temporality was found associated with non-adherence to medication and uncontrolled HbA(1c) in type 2 diabetic patients. Treatment strategies for chronic diseases should be tailored according to this novel dimension of psychology. PMID: 21550831 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4823666 Thu, 05 May 2011 23:00:00 +0100 4823666 http://www.medworm.com/index.php?rid=4823665&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21550832%26dopt%3DAbstract Authors: Sani MA, Campana-Salort E, Begu-Lecorroller A, Baccou M, Valéro R, Vialettes B The present clinical report describes the case of a spontaneously resolving rhabdomyolysis episode in a type 1 diabetic patient, who presented with multiple risk factors of this muscle complication, including uncontrolled brittle diabetes with sequences of hyper- and hypoglycaemic episodes in the same day, caloric restriction and intensive exercise. It should be borne in mind that rhabdomyolysis is not particularly rare in diabetes and can be severe. To raise clinicians' awareness of a possible rhabdomyolysis diagnosis, the various clinical conditions that are likely to lead to this complication in diabetic patients are also reviewed here. PMID: 21550832 [PubMed - as supplied by publisher] (Sou... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4823665 Thu, 05 May 2011 23:00:00 +0100 4823665 http://www.medworm.com/index.php?rid=4823667&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21511510%26dopt%3DAbstract CONCLUSION: Our findings confirm the inverse modulating effect of functional GCKR variants on triglycerides and glucose levels in obese paediatric patients and healthy normal-weight controls. The results of our study strongly suggest that the minor alleles confer protection against the development of obesity in children. The findings also suggest that the minor alleles of functional GCKR may protect against diabetes and the metabolic syndrome in adults. PMID: 21511510 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4823667 Mon, 18 Apr 2011 23:00:00 +0100 4823667 http://www.medworm.com/index.php?rid=4823668&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21507694%26dopt%3DAbstract Authors: Lolmède K, Duffaut C, Zakaroff-Girard A, Bouloumié A Obesity, defined as the excess development of adipose tissue, is an important risk factor for metabolic and cardiovascular diseases such as type 2 diabetes, hypertension and atherosclerosis. Over the past few years, metabolic inflammation has emerged as a major process underlying the link between obesity and its associated pathologies. Adipose tissue appears to play a primary and crucial role as a source and site of inflammation. Accumulation of immune cells within adipose tissue occurs in obese conditions. The present review focuses on the relationship between adipose tissue and immune cells, including macrophages, dendritic cells, T and B lymphocytes, and natural killer cells, in both the physiological state and under ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4823668 Sun, 17 Apr 2011 23:00:00 +0100 4823668 http://www.medworm.com/index.php?rid=4663780&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21435929%26dopt%3DAbstract CONCLUSION: Elderly people with type 2 diabetes are receiving better quality of care and have better control of cardiovascular risk factors than before. However, improvement is still required, in particular by performing better screening for complications. In this patient population, it is important to carefully monitor the risks for hypoglycaemia, hypotension, malnutrition and contraindications related to renal function. PMID: 21435929 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4663780 Tue, 22 Mar 2011 00:00:00 +0100 4663780 http://www.medworm.com/index.php?rid=4663779&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21435930%26dopt%3DAbstract Authors: Antuna-Puente B, Disse E, Rabasa-Lhoret R, Laville M, Capeau J, Bastard JP Insulin resistance represents a major public health problem, as it plays a major role in the pathophysiology of type 2 diabetes mellitus; it is also associated with increased cardiovascular risk and atherogenic dyslipidaemia, and is a central component of the cluster of metabolic abnormalities that comprise the metabolic syndrome. Thus, the development of tools to quantify insulin sensitivity/resistance has been the main objective of a number of studies. Insulin resistance can be estimated with the use of several biological measurements that evaluate different aspects of this complex situation. To that end, it requires various resources, ranging from just a single fasting blood sample for simple indices... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4663779 Tue, 22 Mar 2011 00:00:00 +0100 4663779 http://www.medworm.com/index.php?rid=4604579&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21398163%26dopt%3DAbstract CONCLUSION: LV hypertrophy was found in one-third of asymptomatic diabetic patients, while LV dilatation, systolic dysfunction or hypokinesia was seen in<10%. The main predictors of LV abnormalities were microalbuminuria and silent CAD. The presence of LV hypertrophy with another abnormality should raise the possibility of the presence of silent CAD. PMID: 21398163 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4604579 Fri, 11 Mar 2011 00:00:00 +0100 4604579 http://www.medworm.com/index.php?rid=4604580&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21393044%26dopt%3DAbstract CONCLUSION: MetS is associated with poorer PA performance in patients with schizophrenia. The additional burden of MetS places patients with schizophrenia at even greater risk for physical and functional limitations in daily life. PMID: 21393044 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4604580 Tue, 08 Mar 2011 00:00:00 +0100 4604580 http://www.medworm.com/index.php?rid=4604581&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21377910%26dopt%3DAbstract CONCLUSION: Elevated serum uric acid predicted IFG and T2DM only in Japanese women undergoing regular health checkups. PMID: 21377910 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4604581 Fri, 04 Mar 2011 00:00:00 +0100 4604581 http://www.medworm.com/index.php?rid=4604582&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21377387%26dopt%3DAbstract CONCLUSION: Our results clearly show an exacerbation of innate immunity in PBMNC with T2D that was possibly hyperglycaemia-induced. These data, when analyzed together, suggest the importance of innate immunity in the pathogenesis of T2D. PMID: 21377387 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4604582 Thu, 03 Mar 2011 00:00:00 +0100 4604582 http://www.medworm.com/index.php?rid=4542035&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21354844%26dopt%3DAbstract CONCLUSION: Insulin analogues have differential effects on the expression of insulin-signaling molecules in human pancreatic islets that are also dependent on the degree of glucose exposure. PMID: 21354844 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4542035 Fri, 25 Feb 2011 00:00:00 +0100 4542035 http://www.medworm.com/index.php?rid=4542036&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21349756%26dopt%3DAbstract CONCLUSION: Validated clinical and paraclinical tools demonstrated the efficacy of Pédimed(®) in improving xerosis and reducing fissures of the feet in diabetic patients. PMID: 21349756 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4542036 Tue, 22 Feb 2011 00:00:00 +0100 4542036 http://www.medworm.com/index.php?rid=4542037&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21345709%26dopt%3DAbstract CONCLUSION: Although more studies are needed to confirm the role of VTD in the treatment of T2DM, there is nevertheless enough evidence at this time to suggest a need to maintain 25-OH vitamin D levels in T2DM patients around 30ng/mL over the course of a year. PMID: 21345709 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4542037 Mon, 21 Feb 2011 00:00:00 +0100 4542037 http://www.medworm.com/index.php?rid=4542038&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21333580%26dopt%3DAbstract CONCLUSION: Analyses based on a systematic review showed that treatment with IAsp in T1DM patients resulted in moderately better metabolic control and treatment satisfaction than RHI. In T2DM patients, meta-analysis showed improvement in PPG, but not in any other outcomes. PMID: 21333580 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4542038 Wed, 16 Feb 2011 00:00:00 +0100 4542038 http://www.medworm.com/index.php?rid=4485047&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21317006%26dopt%3DAbstract Authors: Rigaud D, Pennacchio H, Bizeul C, Reveillard V, Vergès B BACKGROUND: To study the long-term prognosis of anorexia nervosa (AN), 484 adult AN patients were followed on a mean duration of 13 years. RESULTS: The mortality rate was 1.2%. Eight factors were linked to the lack of recovery at 2 years: low BMI at discharge, low energy and fat intakes, high drive for excessive exercising, high score for perfectionism, for interpersonal distrust and for anxiety, use of tube-feeding and adhesion to treatment (P<0.02). Four factors explained the risk of the binge/purging form at 2 years: having had binge-eating disorder and overweight before AN, having had purging episodes within the first 2 years of AN; having had very high energy intakes through meals and being not treated by t... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4485047 Fri, 11 Feb 2011 00:00:00 +0100 4485047 http://www.medworm.com/index.php?rid=4485048&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21306933%26dopt%3DAbstract CONCLUSION: Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D. PMID: 21306933 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4485048 Mon, 07 Feb 2011 00:00:00 +0100 4485048 http://www.medworm.com/index.php?rid=4485049&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21295510%26dopt%3DAbstract Authors: Räkel A, Karelis AD With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality. New-onset diabetes after transplantation (NODAT) is a common complication of solid-organ transplantation, and is a strong predictor of graft failure and cardiovascular mortality in the transplant population. Risk factors for NODAT in transplant recipients are similar to those in non-transplant patients, but transplant-specific risk factors such as hepatitis C (HCV) infection, corticosteroids and calcineurin inhibitors play a dominant role in NODAT pathogenesis. Management of NODAT is similar to type 2 diabetes management in the general population. However, adjusting the immunosuppressant regime... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4485049 Wed, 02 Feb 2011 00:00:00 +0100 4485049 http://www.medworm.com/index.php?rid=4485050&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21277245%26dopt%3DAbstract CONCLUSION: The prevalence of hypertension is high in overweight and obese adolescents, and higher in boys than in girls. Hypertension and arterial stiffness, as determined by high PP levels, were associated with abdominal adiposity. It is recommended that prehypertension be identified in overweight adolescents and that lifestyle changes be made to avoid its evolution towards obesity and hypertension. PMID: 21277245 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4485050 Thu, 27 Jan 2011 00:00:00 +0100 4485050 http://www.medworm.com/index.php?rid=4417807&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21273106%26dopt%3DAbstract CONCLUSION: Renal insufficiency often occurs without albuminuria, suggesting aetiologies distinct from classical diabetic nephropathy, and is strongly associated with vascular comorbidities. Hypoalbuminaemia is more strongly associated with inflammation than with albuminuria and malnutrition. Malnutrition, hypoalbuminaemia, low cholesterol levels and anaemia are not associated with renal insufficiency, likely due to the very high prevalence of these abnormalities in the whole population. These features must be taken into account when organizing the global care of elderly diabetic patients. PMID: 21273106 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4417807 Tue, 25 Jan 2011 00:00:00 +0100 4417807 http://www.medworm.com/index.php?rid=4417808&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21257329%26dopt%3DAbstract CONCLUSION: Altogether, these results show that our model of exposure in utero to maternal diabetes led to normal birth weights, and induced transient glucose intolerance and increased blood pressure with no major effects on lipid metabolism. It also suggests that a hyperglycaemic fetal environment may be able to 'programme' hypertension and glucose intolerance, but not alter lipid metabolism. PMID: 21257329 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4417808 Fri, 21 Jan 2011 00:00:00 +0100 4417808 http://www.medworm.com/index.php?rid=4417811&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21236715%26dopt%3DAbstract CONCLUSION: During moderate diet-induced weight loss, the use of BIA leads to estimates of changes in body composition at the individual level that can differ substantially from those assessed by DXA, indicating that BIA and DXA cannot be used interchangeably. However, BIA in this context may be used for assessing changes in body composition at group level. PMID: 21236715 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4417811 Wed, 12 Jan 2011 00:00:00 +0100 4417811 http://www.medworm.com/index.php?rid=4417810&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21236716%26dopt%3DAbstract CONCLUSION: Diabetes prevalence is low in Mozambique, but most diabetic patients were neither aware of their condition nor being treated pharmacologically, thus posing serious challenges to the provision of adequate care in an already disadvantageous context. PMID: 21236716 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4417810 Wed, 12 Jan 2011 00:00:00 +0100 4417810 http://www.medworm.com/index.php?rid=4417809&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21236717%26dopt%3DAbstract Authors: Bouchoucha M, Uzzan B, Cohen R Digestive disorders (diarrhoea, vomiting) represent the most common metformin side-effects (around 30%) with this first-line drug treatment for type 2 diabetes. In healthy individuals, metformin affects glucose, vitamin B12 and the digestive uptake of bile salts. In the colon, it acts locally by modifying glucose cell metabolism. Different pathophysiological hypotheses have been proposed to explain the metformin-induced diarrhoea and vomiting, which can sometimes cause the patient to stop an effective treatment. These theories include stimulation of intestinal secretion of serotonin, changes in incretin and glucose metabolism, and bile-salt malabsorption. However, none of these hypotheses can be considered an adequate pathophysiological explanati... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4417809 Wed, 12 Jan 2011 00:00:00 +0100 4417809 http://www.medworm.com/index.php?rid=4355397&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21195002%26dopt%3DAbstract CONCLUSION: The age-standardized prevalence of diabetes and prediabetes were 11.1% and 13.2%, respectively. Older age, family history of diabetes, obesity and hypertension were positively related, while educational status was negatively related, to the presence of diabetes. PMID: 21195002 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355397 Wed, 29 Dec 2010 00:00:00 +0100 4355397 http://www.medworm.com/index.php?rid=4355398&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21193341%26dopt%3DAbstract CONCLUSION: These findings support the current public-health recommendations for weight control and particularly among ethnic groups at high risk for diabetes. PMID: 21193341 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355398 Tue, 28 Dec 2010 00:00:00 +0100 4355398 http://www.medworm.com/index.php?rid=4355399&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21190885%26dopt%3DAbstract CONCLUSION: The high prevalence of obesity combined with a high prevalence of diabetes indicates a potential for further increases in the prevalence of diabetes and cardiovascular disease in Mayotte. Preventative action against obesity, diabetes and hypertension is required now, as well as plans for appropriate healthcare delivery in the island. PMID: 21190885 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355399 Mon, 27 Dec 2010 00:00:00 +0100 4355399 http://www.medworm.com/index.php?rid=4355400&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21185213%26dopt%3DAbstract Authors: Migrenne S, Le Foll C, Levin BE, Magnan C Nutrient sensitive neurons (glucose and fatty acids (FA)) are present in many sites throughout the brain, including the hypothalamus and brainstem, and play a key role in the neural control of energy and glucose homeostasis. Through neuronal output, FA may modulate feeding behaviour as well as both insulin secretion and action. For example, central administration of oleate inhibits food intake and glucose production in rats. This suggests that daily variations in plasma FA concentrations might be detected by the central nervous system as a signal which contributes to the regulation of energy balance. At the cellular level, subpopulations of neurons in the ventromedial and arcuate hypothalamic nuclei are selectively either inhibited or ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355400 Wed, 22 Dec 2010 00:00:00 +0100 4355400 http://www.medworm.com/index.php?rid=4355401&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21169044%26dopt%3DAbstract CONCLUSION: In spite of being managed at specialized centres that were, in general, following the agreed-upon published guidelines, the prognosis for diabetic foot infection remains poor, with a high rate (48%) of lower-limb amputation. PMID: 21169044 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355401 Fri, 17 Dec 2010 00:00:00 +0100 4355401 http://www.medworm.com/index.php?rid=4355402&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21159536%26dopt%3DAbstract CONCLUSION: A single exercise bout decreases BP in T2D patients over a 24h period, with RES being more effective than AER exercise for BP control. PMID: 21159536 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355402 Mon, 13 Dec 2010 00:00:00 +0100 4355402 http://www.medworm.com/index.php?rid=4355404&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21147013%26dopt%3DAbstract CONCLUSION: In patients at risk of G6PD deficiency, the possibility of haemolysis should be explored in case of diabetes crisis. In African patients with KPT2D diabetes, potentially oxidative hypoglycaemic agents should be avoided in the remission phase of the disease. G6PD deficiency and diabetes can aggravate each other, and diabetes could be aetiologically associated with G6PD deficiency. PMID: 21147013 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355404 Fri, 10 Dec 2010 00:00:00 +0100 4355404 http://www.medworm.com/index.php?rid=4355403&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21147014%26dopt%3DAbstract CONCLUSION: The number of centres using insulin pump therapy for diabetic children and the number of children treated by insulin pump were increased fourfold and 10-fold, respectively, from 2001 to 2007, indicating greater access to pump therapy in the French paediatric population. The present survey is still ongoing to evaluate the decision-making criteria that influence the initiation of insulin pump therapy in T1D paediatric patients. PMID: 21147014 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355403 Fri, 10 Dec 2010 00:00:00 +0100 4355403 http://www.medworm.com/index.php?rid=4355406&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21145772%26dopt%3DAbstract CONCLUSION: This pilot study demonstrated the value and effectiveness of RETIDIAB(®), a new CME website exclusively devoted to DR management. PMID: 21145772 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355406 Wed, 08 Dec 2010 00:00:00 +0100 4355406 http://www.medworm.com/index.php?rid=4355405&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21145773%26dopt%3DAbstract CONCLUSION: The c.584C>T EL polymorphism is associated with a higher risk of diabetic retinopathy that could be linked to modifications in HDL-cholesterol metabolism and blood pressure levels. PMID: 21145773 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355405 Wed, 08 Dec 2010 00:00:00 +0100 4355405 http://www.medworm.com/index.php?rid=4355407&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21145274%26dopt%3DAbstract CONCLUSION: In this cross-sectional analysis of a large diabetic population at very high risk of both DR and cataract, chronic therapy with statins was not cataractogenic, and the presence of cataract was not associated with more statin or other lipid-lowering drug use. This suggests that the benefits of statin therapy in T2D may far outweigh any potential ocular drawbacks as a side effect which, in any case, were not supported by our findings. PMID: 21145274 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355407 Tue, 07 Dec 2010 00:00:00 +0100 4355407 http://www.medworm.com/index.php?rid=4355410&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21144786%26dopt%3DAbstract CONCLUSION: Our study compared EDR linked to physiological aging with that observed in the case of STZ-induced diabetes over a short-term period, and demonstrated the beneficial effect of AG. PMID: 21144786 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355410 Mon, 06 Dec 2010 00:00:00 +0100 4355410 http://www.medworm.com/index.php?rid=4355409&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21144787%26dopt%3DAbstract CONCLUSION: The FINDRISC questionnaire performed well as a screening tool for the cross-sectional detection of unknown diabetes, IFG, IGT and the MetS in the Greek population. PMID: 21144787 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355409 Mon, 06 Dec 2010 00:00:00 +0100 4355409 http://www.medworm.com/index.php?rid=4355408&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21144788%26dopt%3DAbstract CONCLUSION: The present study data provided no clear evidence to support an association between serum α- or β-carotene concentration and advanced beta-cell autoimmunity. PMID: 21144788 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4355408 Mon, 06 Dec 2010 00:00:00 +0100 4355408 http://www.medworm.com/index.php?rid=4258553&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21131223%26dopt%3DAbstract CONCLUSION: Our results suggest that 12-week atorvastatin is effective in reducing Lp(a) in dyslipidaemic patients free of CVD. Furthermore, this is also the first evidence that the drug increases IL-10 in a dose-dependent manner. PMID: 21131223 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4258553 Fri, 03 Dec 2010 00:00:00 +0100 4258553 http://www.medworm.com/index.php?rid=4258557&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21126899%26dopt%3DAbstract CONCLUSION: T1D may reveal as GDM in women with or without risk factors for GDM and is associated with a poor prognosis, partly because the correct diagnosis and treatment are delayed. Whether screening for autoimmune markers of T1D should be performed more systematically in women with GDM deserves to be studied. PMID: 21126899 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4258557 Tue, 30 Nov 2010 00:00:00 +0100 4258557 http://www.medworm.com/index.php?rid=4258556&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21126900%26dopt%3DAbstract CONCLUSION: While fasting-based indices of IS are a suitable option for large cohorts, OGTT-derived indices may represent a useful compromise for obtaining both clinical (glucose tolerance) and physiological (insulin sensitivity) information, making them particularly useful for large-scale physiological and epidemiological studies. PMID: 21126900 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4258556 Tue, 30 Nov 2010 00:00:00 +0100 4258556 http://www.medworm.com/index.php?rid=4258555&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21126901%26dopt%3DAbstract CONCLUSION: Insulin resistance is frequent in Afro-Caribbean women with HIV infection. Overweight and obesity are major risk factors in such a population. Systematic screening for insulin resistance should be carried out in this population, which has a high prevalence of T2D. PMID: 21126901 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4258555 Tue, 30 Nov 2010 00:00:00 +0100 4258555 http://www.medworm.com/index.php?rid=4258554&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21126902%26dopt%3DAbstract Authors: Valensi P, Picard S Cardiovascular disease (CVD) remains the primary cause of morbidity and mortality in patients with diabetes. Lipid-lowering therapy (LLT) is often required, and statin drugs are usually the first-line therapy. However, even when LDL-cholesterol values are within the target range, a substantial residual risk persists. Fibrates may help to lower this risk, especially in patients with high triglyceride and low HDL-cholesterol levels, as suggested by the lipid ACCORD trial. Furthermore, they may even have beneficial effects on the development of microvascular complications such as nephropathy and especially retinopathy, as suggested by the results of the FIELD study. Data suggest benefit with fenofibrate on diabetic retinopathy, with significant effects on the ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4258554 Tue, 30 Nov 2010 00:00:00 +0100 4258554 http://www.medworm.com/index.php?rid=4224355&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21112227%26dopt%3DAbstract CONCLUSION: Obesity still appears to be rare in Senegalese urban-dwelling men, whereas women, despite their overweight, have no untoward cardiometabolic profiles. However, the observed correlations between cardiometabolic risk factors and the amount and/or distribution of body fat suggest that obesity prevention should not be overlooked in the public health agenda for sub-Saharan Africa. PMID: 21112227 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4224355 Thu, 25 Nov 2010 00:00:00 +0100 4224355 http://www.medworm.com/index.php?rid=4205613&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109476%26dopt%3DAbstract CONCLUSION: Serum RBP4 levels are significantly increased in pregnancy, independent of age and BMI, and are also considerably higher in pregnant women with GDM than in those with normal glucose tolerance. In addition, serum RBP4 levels appear to be a valuable marker of insulin resistance and dysfunctional lipid metabolism in pregnancy. PMID: 21109476 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4205613 Tue, 23 Nov 2010 00:00:00 +0100 4205613 http://www.medworm.com/index.php?rid=4173015&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21075654%26dopt%3DAbstract Authors: Burcelin R, Dejager S Over the past 2years, more than 1300 manuscripts have been published on glucagon-like peptide-1 (GLP-1) and yet, what do we know about it for sure? The European Club for the Study of GLP-1 (EuCSGLP-1) has debated the latest controversies concerning GLP-1, including both fundamental and clinical aspects, and concluded that the control of glucose metabolism by GLP-1 requires paracrine activation of the enteric nervous system to regulate numerous physiological functions. This involves-but is not limited to-the endocrine pancreas, liver, cardiovascular system, gastric-emptying and the brain. For this reason, the role of GLP-1 as an endocrine hormone has come under question. As systemic concentration of the peptide was not thought to be relevant to its physiol... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4173015 Fri, 12 Nov 2010 00:00:00 +0100 4173015 http://www.medworm.com/index.php?rid=4173016&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21074472%26dopt%3DAbstract Authors: Issad T, Masson E, Pagesy P O-GlcNAc glycosylation (O-GlcNAcylation) corresponds to the addition of N-acetylglucosamine on serine and threonine residues of cytosolic and nuclear proteins. O-GlcNAcylation is a dynamic post-translational modification, analogous to phosphorylation, that regulates the stability, the activity or the subcellular localisation of target proteins. This reversible modification depends on the availability of glucose and therefore constitutes a powerful mechanism by which cellular activities are regulated according to the nutritional environment of the cell. O-GlcNAcylation has been implicated in important human pathologies including Alzheimer disease and type-2 diabetes. Only two enzymes, OGT and O-GlcNAcase, control the O-GlcNAc level on proteins. There... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4173016 Wed, 10 Nov 2010 00:00:00 +0100 4173016 http://www.medworm.com/index.php?rid=4158456&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21055993%26dopt%3DAbstract CONCLUSION: TE is well implemented in French hospitals, but lacks homogeneity and standardization. Training is inadequate from both qualitative and quantitative points of view, and evaluation of TE procedures needs to be developed. There is also a need for more funding and dedicated qualified staff, a lack of which is partly due to the fact that TE is not a recognized medical activity in hospitals. PMID: 21055993 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4158456 Wed, 03 Nov 2010 00:00:00 +0100 4158456 http://www.medworm.com/index.php?rid=4109108&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20980182%26dopt%3DAbstract CONCLUSION: This study found a positive association between area deprivation and TD, and adds further evidence to the scanty data so far available on this topic. This finding should contribute to pinpointing priority action areas for programmes of diabetes prevention. However, more research is needed to further elucidate the mechanism(s) linking area deprivation and diabetes. PMID: 20980182 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4109108 Sun, 24 Oct 2010 23:00:00 +0100 4109108 http://www.medworm.com/index.php?rid=4098800&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20951621%26dopt%3DAbstract CONCLUSION: In a population with low-to-moderate mortality risk, waist circumference alone did not identify high-risk subjects, thus suggesting that a more global approach is necessary. PMID: 20951621 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4098800 Wed, 13 Oct 2010 23:00:00 +0100 4098800 http://www.medworm.com/index.php?rid=4098801&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20947405%26dopt%3DAbstract CONCLUSION: The DIABASIS survey provides important information for diabetes care by identifying distinct patients' profiles that express different degrees of difficulty in implementing self-management. For this reason, patients in each category require different kinds of customized support from their physician to induce behavioural changes that may be key in improving their metabolic control. PMID: 20947405 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4098801 Mon, 11 Oct 2010 23:00:00 +0100 4098801 http://www.medworm.com/index.php?rid=4066906&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20934897%26dopt%3DAbstract CONCLUSION: Our study indicates that HbA(1c) is strongly predictive of new-onset diabetes in this northern Spanish population, and was similar to FPG and 2hPG in predictive capability. Also, the combined measurement of FPG and HbA(1c) improved their individual predictive performance. PMID: 20934897 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4066906 Thu, 07 Oct 2010 23:00:00 +0100 4066906 http://www.medworm.com/index.php?rid=4066907&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20934364%26dopt%3DAbstract CONCLUSION: Although the observational nature of the present study prevents causal conclusions to be drawn, these preliminary results suggest that promoting therapeutic alliance can improve glycaemic control in type 1 diabetes. PMID: 20934364 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4066907 Wed, 06 Oct 2010 23:00:00 +0100 4066907 http://www.medworm.com/index.php?rid=4030894&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20888279%26dopt%3DAbstract CONCLUSION: Animal-protein consumption was associated with a higher prevalence of diabetes among the elderly, whereas protein intakes, especially from plant sources, within the recommended range appear to confer considerable protection. This suggests that reducing or controlling the burden of diabetes through dietary means in the elderly should include monitoring their daily protein intake. PMID: 20888279 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4030894 Tue, 28 Sep 2010 23:00:00 +0100 4030894 http://www.medworm.com/index.php?rid=4030893&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20888280%26dopt%3DAbstract Authors: Reznik Y Continuous subcutaneous insulin infusion (CSII) using an external pump is widely used for the treatment of type 1 diabetes, but has been less evaluated in type 2 diabetes. This review analyzes the open-label as well as randomized controlled studies performed in type 2 diabetic patients. The efficacy of CSII is compared with multiple daily injections (MDI) in terms of glycaemic control, weight variation, insulin requirements, treatment satisfaction and hypoglycaemic events. CSII may be offered as an alternative treatment to type 2 diabetic patients with poor glycaemic control despite high-dose insulin requirements administered through MDI. PMID: 20888280 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=4030893 Tue, 28 Sep 2010 23:00:00 +0100 4030893 http://www.medworm.com/index.php?rid=3965957&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20832344%26dopt%3DAbstract CONCLUSION: Rates of SMI and significant CAD in asymptomatic high-risk type 2 diabetic patients receiving intensive care of risk factors are low, and SPECT and DE are similar in the detection of SMI and CAD. Coronary revascularization and intensive CV risk-factor therapy are associated with a low rate of adverse CV events at 3years, whichever stress test was used. PMID: 20832344 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3965957 Tue, 07 Sep 2010 23:00:00 +0100 3965957 http://www.medworm.com/index.php?rid=3913409&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20739207%26dopt%3DAbstract CONCLUSION: The good sensitivity, specificity and reproducibility of EZSCAN make it a feasible alternative for assessing sudomotor dysfunction, a clinical manifestation of autonomic neuropathy in diabetic patients. The test takes<3min to perform, and requires neither special patient preparation nor medical personnel training. PMID: 20739207 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3913409 Sun, 22 Aug 2010 23:00:00 +0100 3913409 http://www.medworm.com/index.php?rid=3913408&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20739208%26dopt%3DAbstract CONCLUSION: These results suggest that variations in resistin concentrations are not directly related to susceptibility to type 2 diabetes. However, it may be that resistin plays a role in the pathogenesis of obesity and insulin resistance, both of which could, indirectly, contribute to the development of type 2 diabetes. PMID: 20739208 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3913408 Sun, 22 Aug 2010 23:00:00 +0100 3913408 http://www.medworm.com/index.php?rid=3876027&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20708423%26dopt%3DAbstract CONCLUSION: These findings suggest that MetS does not predict mortality later in life and, of the separate components of MetS, only low HDL cholesterol is predictive of mortality in women. Also, even markedly higher blood pressure values than those included in the criteria for MetS fail to predict mortality in this age group. PMID: 20708423 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3876027 Tue, 10 Aug 2010 23:00:00 +0100 3876027 http://www.medworm.com/index.php?rid=3845499&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20688551%26dopt%3DAbstract Authors: Monnier L, Colette C PMID: 20688551 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3845499 Mon, 02 Aug 2010 23:00:00 +0100 3845499 http://www.medworm.com/index.php?rid=3813908&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20675173%26dopt%3DAbstract The objectives of this review are to assess the effects of exercise on the prevention of type 2 diabetes in high-risk individuals and on glycaemic control in type 2 diabetic patients. Considering the available reports, there is unequivocal and strong evidence that physical exercise can prevent or delay progression to type 2 diabetes in subjects with impaired glucose tolerance. Also, lifestyle interventions, including diet and physical exercise, can result in a reduction of around 50% in diabetes incidence that persists even after the individual lifestyle counselling has stopped. In addition, short-term randomized studies have confirmed that physical training based on endurance and/or resistance exercises can also improve blood glucose control in type 2 diabetics with a mean glycated haemog... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3813908 Thu, 29 Jul 2010 23:00:00 +0100 3813908 http://www.medworm.com/index.php?rid=3813909&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20673644%26dopt%3DAbstract CONCLUSION: Irrespective of definition, MetS is a significant predictor of incident CVD events and incident diabetes. Also, the new Harmonization definition may be a better predictor of incident CVD than the sum of its components. PMID: 20673644 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3813909 Mon, 26 Jul 2010 23:00:00 +0100 3813909 http://www.medworm.com/index.php?rid=3714489&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20579916%26dopt%3DAbstract CONCLUSION: T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH. PMID: 20579916 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3714489 Tue, 22 Jun 2010 23:00:00 +0100 3714489 http://www.medworm.com/index.php?rid=3714488&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20579917%26dopt%3DAbstract CONCLUSION: Both HbA(1c) and beta-cell function decreased over 10 years with SU treatment, but such treatment was not associated with a pronounced decline in beta-cell function. These results, however, need to be interpreted with caution, as this was an observational study. Nevertheless, the present study findings do not support the notion that SU, as used in clinical practice, is harmful to beta-cell function. PMID: 20579917 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3714488 Tue, 22 Jun 2010 23:00:00 +0100 3714488 http://www.medworm.com/index.php?rid=3684530&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20561808%26dopt%3DAbstract Authors: Delaere F, Magnan C, Mithieux G Glycolysis is an essential metabolic function that lies at the core of any cellular life. Glucose homoeostasis is, thus, a crucial physiological function of living organisms. A system of plasma glucose-sensing in the portal vein plays a key role in this homoeostasis. Connected to the hypothalamus via the peripheral nervous system, the system allows the body to adapt its response to any variation of portal glycaemia. The hypothalamus controls food intake (exogenous glucose supply) and hepatic glycogenolysis (endogenous glucose supply). Intestinal gluconeogenesis, via the release of glucose into the portal vein, plays a key role in the control of hunger and satiety, and of endogenous glucose production through the modulation of liver insulin sensi... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3684530 Wed, 16 Jun 2010 23:00:00 +0100 3684530 http://www.medworm.com/index.php?rid=3677655&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20554237%26dopt%3DAbstract Authors: Simon D, Balkau B A moderate increase in cancer risk has been shown in diabetic patients and in individuals with abnormal glucose tolerance, mainly for digestive sites, independently of obesity, with in contrast, a protective effect for prostate cancer. Insulin-resistance with compensatory hyperinsulinemia, and elevated levels of circulating growth factors are usually considered to be the link between cancer and hyperglycaemia, through activated cell proliferation. Treatments inducing elevated plasma insulin seem to increase cancer risk but insulin-sensitizers (metformine, thiazolidinediones) seem to reduce cancer risk. In 2009, there was a controversy on the specific action of glargine insulin to increase cancer risk, from an observational study in Germany, which accumulated ... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3677655 Mon, 31 May 2010 23:00:00 +0100 3677655 http://www.medworm.com/index.php?rid=3656854&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20537932%26dopt%3DAbstract CONCLUSION: There was a significant discordance between LDL and non-HDL cholesterol levels in diabetes patients with high triglycerides or the MS. This might explain patients' high residual CV risk despite having achieved their desirable LDL cholesterol levels. Thus, treating both non-HDL and LDL cholesterol to achieve target values should be considered to reduce residual CV risk in patients with diabetes. PMID: 20537932 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3656854 Mon, 24 May 2010 23:00:00 +0100 3656854 http://www.medworm.com/index.php?rid=3586497&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20483647%26dopt%3DAbstract CONCLUSION: Self-rated health and psychological well-being, and HRQL, are all considerably poorer among patients with diabetes vs those without diabetes. The poorest quality of life among those with diabetes associated with female gender, depression, lack of exercise and obesity. PMID: 20483647 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3586497 Sun, 16 May 2010 23:00:00 +0100 3586497 http://www.medworm.com/index.php?rid=3586496&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20483648%26dopt%3DAbstract CONCLUSION: Fat and fructose both increased IHCL, but fructose increased, while fat decreased, VLDL triacylglycerols. However, excess fat and fructose combined had additive effects on IHCL and neutralizing effects on VLDL triglycerides. This suggests that fructose stimulates, while fat inhibits, hepatic VLDL triacylglycerol secretion. PMID: 20483648 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3586496 Sun, 16 May 2010 23:00:00 +0100 3586496 http://www.medworm.com/index.php?rid=3574157&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472485%26dopt%3DAbstract Authors: Bourdel-Marchasson I, Lapre E, Laksir H, Puget E Cognitive decline and dementia both place a heavy burden on patients and their relatives, and any means of preventing such age-related changes are worthy of consideration. Those who have the metabolic syndrome with or without diabetes suffer more often from dysexecutive problems and slower psychomotor speed than do other patients. In epidemiological studies, diabetes has appeared to be a risk factor for all types of dementia, including vascular dementia, although the role of the metabolic syndrome in the risk of Alzheimer's disease is still a matter of debate. The possible mechanisms of cognitive alterations are multiple, and may differ according to age group and duration of diabetes or the metabolic syndrome. Drug interventiona... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3574157 Thu, 13 May 2010 23:00:00 +0100 3574157 http://www.medworm.com/index.php?rid=3551151&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20452799%26dopt%3DAbstract Authors: Thielen V, Scheen A, Bringer J, Renard E The effectiveness of a specific educational programme involving the use of a real-time glucose-sensor system (Guardian RT((R))) to improve glucose control was investigated in patients with poorly controlled type 2 diabetes despite insulin therapy. Ten patients participated in a randomized crossover study comparing two 3-month periods, during which glucose levels were monitored by either self-monitoring of blood glucose (SMBG) alone or by Guardian RT((R)) (restricted to 1 week per month) in addition to SMBG. Only four of the enrolled patients completed both periods, while dropouts were mainly due to technical difficulties in using the device. All six patients who completed the first 3-month period showed a reduction in glycated haemoglob... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3551151 Thu, 06 May 2010 23:00:00 +0100 3551151 http://www.medworm.com/index.php?rid=3547066&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20447851%26dopt%3DAbstract CONCLUSION: Exenatide significantly increased HOMA-B and hyperbolic product over a 6-month treatment period with no overall change in insulin sensitivity, despite weight loss. Thus, improved beta-cell function rather than increased insulin sensitivity accounts for the bulk of HbA(1c) reduction following 6months of exenatide treatment. PMID: 20447851 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3547066 Mon, 03 May 2010 23:00:00 +0100 3547066 http://www.medworm.com/index.php?rid=3534595&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20434384%26dopt%3DAbstract CONCLUSION: The number of examinations carried out in the region of Franche-Comté greatly exceeded the number of patients required for screening. However, practical feasibility is not the only criterion needed to guarantee the quality of a large-scale screening programme. Our results raise the question of the relevance of the current screening selection criteria. PMID: 20434384 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3534595 Tue, 27 Apr 2010 23:00:00 +0100 3534595 http://www.medworm.com/index.php?rid=3444173&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20363171%26dopt%3DAbstract CONCLUSION: Our data show that, among older institutionalized patients, the prevalence of diabetes is high and the control of diabetes too tight, with a potential risk of hypoglycaemia. Antidiabetic treatment should be reduced when the HbA(1c) value is less than 7.5% in this frail and functionally dependent population. Furthermore, a diabetic diet, prescribed for more than half this population, is useless for glycaemic control and may even impinge on quality of life. PMID: 20363171 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3444173 Wed, 31 Mar 2010 23:00:00 +0100 3444173 http://www.medworm.com/index.php?rid=3435629&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20359928%26dopt%3DAbstract Authors: Bastard JP, Antuna-Puente B, Rabasa-Lhoret R PMID: 20359928 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3435629 Mon, 29 Mar 2010 23:00:00 +0100 3435629 http://www.medworm.com/index.php?rid=3421408&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20347376%26dopt%3DAbstract CONCLUSION: Many type 2 diabetic patients who begin treatment with an OAD will eventually be prescribed insulin. Age, disease severity and the type of prior treatment may affect the rate of the transition. PMID: 20347376 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3421408 Thu, 25 Mar 2010 00:00:00 +0100 3421408 http://www.medworm.com/index.php?rid=3395612&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20303812%26dopt%3DAbstract CONCLUSION: Lipogenesis is expressed in the arterial walls and VSMCs of P. obesus. However, its expression was not increased in diabetes, and did not respond to either T3 or angiotensin II. Therefore, lipogenesis in situ is unlikely to contribute to the accumulation of lipids in the arterial walls of diabetic P. obesus gerbils. PMID: 20303812 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3395612 Thu, 18 Mar 2010 00:00:00 +0100 3395612 http://www.medworm.com/index.php?rid=3395611&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20303813%26dopt%3DAbstract Authors: Borai A, Livingstone C, Farzal A, Kholeif M, Wang T, Ferns G PMID: 20303813 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3395611 Thu, 18 Mar 2010 00:00:00 +0100 3395611 http://www.medworm.com/index.php?rid=3395610&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20303814%26dopt%3DAbstract CONCLUSION: Frequency of sexual activity appears to be unaffected by pump therapy or diabetes, but is decreased by the expected characteristics-namely, age and being single. Also, only 10% of patients believe that CSII is an obstacle during sexual activity and, in particular, because of the catheter. PMID: 20303814 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3395610 Thu, 18 Mar 2010 00:00:00 +0100 3395610 http://www.medworm.com/index.php?rid=3395609&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20303815%26dopt%3DAbstract CONCLUSION: When T2D patients were compared with non-diabetic subjects with similarly controlled levels of hyperglycaemia after oral glucose ingestion, they essentially differed only in peripheral glucose uptake, whereas endogenous glucose production was apparently unaltered. PMID: 20303815 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3395609 Thu, 18 Mar 2010 00:00:00 +0100 3395609 http://www.medworm.com/index.php?rid=3374977&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226708%26dopt%3DAbstract CONCLUSION: To best assess peak postprandial glucose levels, the optimal time for blood glucose monitoring is about 1h and 15min after the start of the meal, albeit with wide interpatient variability. Nevertheless, 80% of post-meal blood glucose peaks were observed at less than 90min after the start of the meal. PMID: 20226708 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3374977 Wed, 10 Mar 2010 00:00:00 +0100 3374977 http://www.medworm.com/index.php?rid=3358328&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20219404%26dopt%3DAbstract CONCLUSION: This study shows that previously published algorithms for computer-aided diagnosis is a reliable alternative to time-consuming manual analysis of fundus photographs when screening for DR. The use of this system would allow considerable timesavings for physicians and, therefore, alleviate the time spent on a mass-screening programme. PMID: 20219404 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3358328 Mon, 08 Mar 2010 00:00:00 +0100 3358328 http://www.medworm.com/index.php?rid=3338810&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20202879%26dopt%3DAbstract CONCLUSION: The combined use of low adiponectin levels and large WC measures has greater discriminative power than using either index alone to identify subjects at particular risk of glucose intolerance and clustering of risk factors. PMID: 20202879 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3338810 Tue, 02 Mar 2010 00:00:00 +0100 3338810 http://www.medworm.com/index.php?rid=3338809&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20202880%26dopt%3DAbstract CONCLUSION: The prevalence of the MetS is markedly high within the population of Great Tunis and especially in women. As these findings predict future increases in cardiovascular disease in these populations, substantial efforts need to be made to fight against obesity and sedentary lifestyles to ameliorate the expected poor health outcomes. PMID: 20202880 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3338809 Tue, 02 Mar 2010 00:00:00 +0100 3338809 http://www.medworm.com/index.php?rid=3323255&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20189425%26dopt%3DAbstract The objectives of this review are to summarize the importance of screening for SMI in a subset of asymptomatic diabetic patients. There is evidence that screening markedly improves the evaluation of cardiovascular risk compared with the usual risk scores. New markers, validated by large-scale studies, are needed to help in identifying the patients with silent coronary stenoses, thereby lowering the number of screened patients. Some indications of benefit with revascularization in patients with silent coronary stenoses are also available. Although it is not yet time to stop screening diabetic patients for SMI, such screening should focus on patients who are at high or intermediate cardiovascular risk. Guidelines need to be updated to increase the value of screening. PMID: 20189425 [PubM... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3323255 Thu, 25 Feb 2010 00:00:00 +0100 3323255 http://www.medworm.com/index.php?rid=3323256&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20188617%26dopt%3DAbstract CONCLUSION: Insulin glargine use throughout pregnancy does not appear to be associated with an increased rate of severe congenital malformations. PMID: 20188617 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3323256 Wed, 24 Feb 2010 00:00:00 +0100 3323256 http://www.medworm.com/index.php?rid=3312782&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20181508%26dopt%3DAbstract CONCLUSION: The In2it((R)) analyzer is suitable for HbA(1c) assay in small laboratory series and for point-of-care testing, and its analytical performance is satisfactory overall. However, several issues related to software need to be improved for optimal application. Also, special attention should be paid concerning the possibility of underestimation of results in cases of high hypertriglyceridaemia. PMID: 20181508 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3312782 Mon, 22 Feb 2010 00:00:00 +0100 3312782 http://www.medworm.com/index.php?rid=3270338&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149705%26dopt%3DAbstract CONCLUSION: These data show that obese Zucker rats display age-related alterations of IR gene expression at both pre- and post-translational stages and, in particular, increased endocytosis and degradation of IR protein. PMID: 20149705 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3270338 Tue, 09 Feb 2010 00:00:00 +0100 3270338 http://www.medworm.com/index.php?rid=3270337&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20149706%26dopt%3DAbstract CONCLUSION: Mostly self-controlled exercise of moderate intensity ameliorated serum levels of pro- and anti-atherogenic markers in patients with T2DM, with no effects on body weight. These data offer further insight into the cardioprotective mechanisms of exercise in patients with T2DM. PMID: 20149706 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3270337 Mon, 08 Feb 2010 00:00:00 +0100 3270337 http://www.medworm.com/index.php?rid=3258918&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20137994%26dopt%3DAbstract CONCLUSION: This study suggests an independent association between skin AF levels and diabetic nephropathy and neuropathy, but not retinopathy, in T1D patients. Prospective studies are needed to confirm the ability of skin AF levels to predict microangiopathy. PMID: 20137994 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3258918 Thu, 04 Feb 2010 00:00:00 +0100 3258918 http://www.medworm.com/index.php?rid=3232293&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116316%26dopt%3DAbstract CONCLUSION: French diabetic patients subsequent to MI undergo fewer angioplasty procedures than do non-diabetic patients. After the acute stage, secondary preventative medications are used more often, with a marked rise in the use of insulin. PMID: 20116316 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3232293 Wed, 27 Jan 2010 00:00:00 +0100 3232293 http://www.medworm.com/index.php?rid=3232292&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20116317%26dopt%3DAbstract CONCLUSION: The DR screening campaign represents a major improvement in diabetic management, as around 80% of the screened patients with DR consulted an ophthalmologist after the screening campaign. However, the overall rate of diabetics having the recommended annual ophthalmological visit in the region of Burgundy remained unchanged. PMID: 20116317 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3232292 Wed, 27 Jan 2010 00:00:00 +0100 3232292 http://www.medworm.com/index.php?rid=3221447&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20106702%26dopt%3DAbstract CONCLUSION: Glucose levels greater than 8.8mmol/L on postoperative day 1 and having three or more hypoglycaemic episodes in the postoperative period were predictive of mortality and morbidity among patients undergoing cardiovascular surgery. This suggests that a multidisciplinary approach may be able to achieve better postoperative blood glucose control. PMID: 20106702 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3221447 Mon, 25 Jan 2010 00:00:00 +0100 3221447 http://www.medworm.com/index.php?rid=3208815&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20097589%26dopt%3DAbstract CONCLUSION: This study showed that a BG target of 100-139mg/dL can be safely achieved with an insulin therapy protocol that can be routinely used in everyday clinical practice. PMID: 20097589 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3208815 Fri, 22 Jan 2010 00:00:00 +0100 3208815 http://www.medworm.com/index.php?rid=3208816&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20097112%26dopt%3DAbstract CONCLUSION: Cassava consumption in South Kivu is not associated with changes in T2D phenotype or in the glucose homoeostasis determinants S, B, BxS and BxS LR. Cassava consumption does not accelerate beta-cell function loss in such a population, whose markedly compromised glucose homoeostasis renders them vulnerable to environmentally acquired beta-cell impairment. PMID: 20097112 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3208816 Thu, 21 Jan 2010 00:00:00 +0100 3208816 http://www.medworm.com/index.php?rid=3208817&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20096618%26dopt%3DAbstract Answer from author about "Efficacity of periodontal treatment on glycaemic control in diabetic patients. A metaanalysis of interventional studies" Diabetes Metab. 2010 Jan 20; Authors: Vergnes JN PMID: 20096618 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3208817 Wed, 20 Jan 2010 00:00:00 +0100 3208817 http://www.medworm.com/index.php?rid=3201972&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20093061%26dopt%3DAbstract Authors: Rötig A Oxidative phosphorylation - ATP synthesis by the oxygen-consuming respiratory chain (RC) - supplies most organs and tissues with a readily usable energy source, and is already fully functioning at birth. This means that, in theory, RC deficiency can give rise to any symptom in any organ or tissue at any age and with any mode of inheritance, due to the two-fold genetic origin of RC components (nuclear DNA and mitochondrial DNA). It has long been erroneously believed that RC disorders originate from mutations of mtDNA as, for some time, only mutations or deletions of mtDNA could be identified. However, the number of disease-causing mutations in nuclear genes is now steadily growing. These genes not only encode the various subunits of each complex, but also the ancil... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3201972 Tue, 19 Jan 2010 00:00:00 +0100 3201972 http://www.medworm.com/index.php?rid=3190014&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20080427%26dopt%3DAbstract Authors: Friedlander AH PMID: 20080427 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3190014 Fri, 15 Jan 2010 00:00:00 +0100 3190014 http://www.medworm.com/index.php?rid=3179548&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20074990%26dopt%3DAbstract When to treat a diabetic patient using an external insulin pump. Expert consensus. Société francophone du diabète (ex ALFEDIAM) 2009. Diabetes Metab. 2010 Jan 12; Authors: Lassmann-Vague V, Clavel S, Guerci B, Hanaire H, Leroy R, Loeuille GA, Mantovani I, Pinget M, Renard E, Tubiana-Rufi N For years, external insulin pumps have enjoyed proven efficacy as an intensive diabetes treatment to improve glycaemic control and reduce hypoglycaemia. Since the last ALFEDIAM guidelines in 1995, however, basal-bolus treatment using a combination of long- and short-acting insulin analogues have emerged and could challenge, at a lower cost, the efficacy of pumps using rapid-acting insulin analogues, considered the 'gold standard' of insulin treatment. Nevertheless, given its th... Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3179548 Tue, 12 Jan 2010 00:00:00 +0100 3179548 http://www.medworm.com/index.php?rid=3179547&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20074991%26dopt%3DAbstract CONCLUSION: Elevated maternal ferritin is not a reflection of excess iron stores, but is related to an increased risk of GDM or IUGR. Also, maternal ferritin levels are not associated with either neonatal iron status or neonatal outcomes. PMID: 20074991 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3179547 Tue, 12 Jan 2010 00:00:00 +0100 3179547 http://www.medworm.com/index.php?rid=3167541&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20060765%26dopt%3DAbstract CONCLUSION: LADA patients demonstrate lower residual beta-cell function than do type 2 diabetes patients. However, those who achieve tight metabolic control do not present with a rapid decline in beta-cell function. Further studies are needed to determine the optimal treatment strategy in such patients. PMID: 20060765 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3167541 Thu, 07 Jan 2010 00:00:00 +0100 3167541 http://www.medworm.com/index.php?rid=3143296&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20045370%26dopt%3DAbstract CONCLUSION: The increased production of PGF(2alpha) probably proceeds, at least in part, independently of the COX pathway and via the isoprostane route. However, it is unclear whether the relatively high levels of PGF(2alpha) are causally related to, or simply coincidental with, fetal malformation. PMID: 20045370 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3143296 Wed, 30 Dec 2009 00:00:00 +0100 3143296 http://www.medworm.com/index.php?rid=3126989&cid=s_35512_15_f&fid=35512&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20036596%26dopt%3DAbstract CONCLUSION: These results indicate the presence of significant lipid peroxidation, protein oxidation and oxidative DNA damage in patients with diabetes. Perturbation of glucose homoeostasis was associated with an increase in oxidants and a concomitant decrease of antioxidant enzymes in the type 2 diabetic patients' blood. The present study suggests that the status of oxidant-antioxidant imbalance may be one of the mechanisms leading to the DNA damage detected in the lymphocytes of type 2 diabetic patients. PMID: 20036596 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism) Diabetes and Metabolism journals http://www.medworm.com/rss/comments.php?id=3126989 Thu, 24 Dec 2009 00:00:00 +0100 3126989