MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diabetologia' source. Fri, 19 Mar 2010 15:17:28 +0100 http://www.medworm.com/index.php?rid=3367558&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa8055m7518n18840%2F Conclusions/interpretation  Our data indicate that islet cholesterol levels and beta cell function are strongly influenced by LDLr-mediated uptake of cholesterol into beta cells. Cholesterol efflux mediated by ABCA1, however, can compensate in hypercholesterolaemia to regulate islet cholesterol levels in vivo. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1691-2Authors J. K. Kruit, University of British Columbia Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics 950 West 28th Ave Vancouver BC Canada V5Z 4H4P. H. C. Kremer, University of British Columbia Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics 950 West 28th A... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3367558 Sun, 14 Mar 2010 11:24:44 +0100 3367558 http://www.medworm.com/index.php?rid=3367559&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr5v830711373ux5j%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-010-1715-yAuthors G. J. S. Cooper, University of Auckland School of Biological Sciences, and Maurice Wilkins Centre of Excellence for Molecular Biodiscovery, Faculty of Science Auckland New ZealandJ. F. Aitken, University of Auckland School of Biological Sciences, and Maurice Wilkins Centre of Excellence for Molecular Biodiscovery, Faculty of Science Auckland New ZealandS. Zhang, University of Auckland School of Biological Sciences, and Maurice Wilkins Centre of Excellence for Molecular Biodiscovery, Faculty of Science Auckland New Zealand Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3367559 Sun, 14 Mar 2010 11:24:43 +0100 3367559 http://www.medworm.com/index.php?rid=3363298&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6926w7102103685%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-010-1712-1Authors F. A. Van Assche, University Hospital Department of Obstetrics and Gynecology Herestraat 49 3000 Leuven BelgiumR. Devlieger, University Hospital Department of Obstetrics and Gynecology Herestraat 49 3000 Leuven BelgiumT. Harder, Charité–Universitätsmedizin Berlin Clinic of Obstetrics, Division of ‘Experimental Obstetrics’ Campus Virchow-Klinikum Berlin GermanyA. Plagemann, Charité–Universitätsmedizin Berlin Clinic of Obstetrics, Division of ‘Experimental Obstetrics’ Campus Virchow-Klinikum Berlin Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3363298 Fri, 12 Mar 2010 06:50:23 +0100 3363298 http://www.medworm.com/index.php?rid=3363299&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu225020tu5102146%2F Conclusions/interpretation  Despite a low risk of progression of retinopathy in pregnant women with type 2 diabetes, sight-threatening deterioration did occur. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1697-9Authors K. L. Rasmussen, Copenhagen University Hospital Department of Endocrinology, Rigshospitalet Blegdamsvej 9 2100 København Ø DenmarkC. S. Laugesen, Copenhagen University Hospital Department of Ophthalmology, Rigshospitalet Copenhagen DenmarkL. Ringholm, Copenhagen University Hospital Department of Endocrinology, Rigshospitalet Blegdamsvej 9 2100 København Ø DenmarkM. Vestgaard, Copenhagen University Hospital Department of Endocrinology, Rigshospitalet Blegdamsvej 9 2100 København Ø DenmarkP. Damm, Copenhagen University Hospital... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3363299 Fri, 12 Mar 2010 06:50:22 +0100 3363299 http://www.medworm.com/index.php?rid=3363300&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32p034l8476q4067%2F Abstract  Pancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. During postprandial periods an elevated level of plasma glucose rapidly stimulates insulin secretion to decrease hepatic glucose output and promote glucose uptake into other tissues, principally muscle and adipose tissues. Beta cell mitochondria play a key role in this process, not only by providing energy in the form of ATP to support insulin secretion, but also by synthesising metabolites (anaplerosis) that can act, both intra- and extramitochondrially, as factors that couple glucose sensing to insulin granule exocytosis. ATP on its own, and possibly modulated by these coupl... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3363300 Fri, 12 Mar 2010 06:50:21 +0100 3363300 http://www.medworm.com/index.php?rid=3360763&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86253l87640n1615%2F Conclusions/interpretation  IMT504 induced a marked recovery of STZ-induced diabetes that correlated with early production of progenitor cell markers, such as nestin and NGN3. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1694-zAuthors M. S. Bianchi, Institute of Biology and Experimental Medicine (IBYME-CONICET) Buenos Aires ArgentinaA. Hernando-Insúa, Immunotech Buenos Aires ArgentinaN. A. Chasseing, Institute of Biology and Experimental Medicine (IBYME-CONICET) Buenos Aires ArgentinaJ. M. Rodríguez, Fundación Pablo Cassará Buenos Aires ArgentinaF. Elías, Fundación Pablo Cassará Buenos Aires ArgentinaN. Lago, Gema Biotech Buenos Aires ArgentinaJ. Zorzopulos, Immunotech Buenos Aires ArgentinaC. Libertun, Institute of Biology and Experimenta... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3360763 Thu, 11 Mar 2010 07:57:09 +0100 3360763 http://www.medworm.com/index.php?rid=3360764&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy3x5876g28673613%2F Conclusions/interpretation  TETA may limit the cardiac and renal/vascular damage inflicted by diabetes through its actions to reinforce antioxidant defence mechanisms, probably acting through selective chelation of ‘loosely-bound’/chelatable Cu(II). It may also improve heparan sulphate homeostasis and bolster antioxidant defence by increasing vascular extracellular superoxide dismutase activity. Urinary albumin/creatinine ratio might prove useful for monitoring TETA treatment. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1698-8Authors J. Lu, University of Auckland School of Biological Sciences, Faculty of Science Private Bag 92019 Auckland New ZealandD. Gong, University of Auckland School of Biological Sciences, Faculty of Science Private B... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3360764 Thu, 11 Mar 2010 07:57:08 +0100 3360764 http://www.medworm.com/index.php?rid=3360765&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6g31klu1685764u%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-010-1709-9Authors A. Jonsson, Lund University Department of Clinical Sciences–Diabetes and Endocrinology, CRC, Malmö University Hospital MAS Malmö SwedenF. Renström, Umeå University Hospital Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Medicine Clinic Level 4, Stair B Umeå 901 87 SwedenV. Lyssenko, Lund University Department of Clinical Sciences–Diabetes and Endocrinology, CRC, Malmö University Hospital MAS Malmö SwedenE. C. Brito, Umeå University Hospital Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Medicine Clinic Level 4, Stair B Umeå 901 87 SwedenB. Isomaa, Folkhälsan Genetic Institute Helsinki F... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3360765 Thu, 11 Mar 2010 02:37:17 +0100 3360765 http://www.medworm.com/index.php?rid=3360766&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuq773r3217488046%2F Conclusions/interpretation  Inhibition of AMPK activity within the beta cell is necessary, but not sufficient for stimulation of insulin secretion by glucose to occur. AMPK activation in extrapancreatic RIP2.Cre-expressing cells might also influence insulin secretion in vivo. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1692-1Authors G. Sun, Imperial College London Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Sir Alexander Fleming Building, Exhibition Road, South Kensington London SW7 2AZ UKA. I. Tarasov, Imperial College London Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Sir Alexander Fleming Bu... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3360766 Thu, 11 Mar 2010 02:37:15 +0100 3360766 http://www.medworm.com/index.php?rid=3355977&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F06vr33821g1h636n%2F Conclusions/interpretation  The presence of diabetes and the degree of glycaemic control are related to respiratory function impairment in morbidly obese women. Therefore, the impact of type 2 diabetes on pulmonary function should be taken into consideration by those providing care for obese people. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1700-5Authors A. Lecube, Institut de Recerca Hospital Universitari Vall d’Hebron CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Diabetes and Metabolism Research Unit Passeig Vall d’Hebron, 119-129 08035 Barcelona SpainG. Sampol, Institut de Recerca Hospital Universitari Vall d’Hebron CIBER Enfermedades Respiratorias (CIBERES), Instituto de ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3355977 Wed, 10 Mar 2010 15:41:29 +0100 3355977 http://www.medworm.com/index.php?rid=3355978&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff64xx87573004470%2F Conclusions/interpretation  Our data provide compelling evidence that NUR77 is a functional regulator of glucose metabolism in skeletal muscle in vivo. Importantly, the diminished content in muscle of obese insulin-resistant men suggests that it might be a potential therapeutic target for the treatment of dysregulated glucose metabolism. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1703-2Authors T. Kanzleiter, Garvan Institute of Medical Research Diabetes and Obesity Research Program 384 Victoria Street, Darlinghurst Sydney NSW 2010 AustraliaE. Preston, Garvan Institute of Medical Research Diabetes and Obesity Research Program 384 Victoria Street, Darlinghurst Sydney NSW 2010 AustraliaD. Wilks, Garvan Institute of Medical Research Diabetes and O... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3355978 Wed, 10 Mar 2010 15:41:28 +0100 3355978 http://www.medworm.com/index.php?rid=3355980&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnn3l436w616v4788%2F Conclusions  The overall frequency of DKA in children with newly diagnosed type 1 diabetes in Austria is high and has not changed during the last 20 years despite a clear increase in the manifestation rate. In particular, children less than 2 years of age have a high risk of DKA at onset. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1704-1Authors E. Schober, Medical University of Vienna Department of Pediatrics Währinger Gürtel 18–20 1090 Vienna AustriaB. Rami, Medical University of Vienna Department of Pediatrics Währinger Gürtel 18–20 1090 Vienna AustriaT. Waldhoer, Medical University of Vienna Department of Epidemiology, Center of Public Health Vienna Austriaon behalf of the Austrian Diabetes Incidence Study Group Jou... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3355980 Wed, 10 Mar 2010 15:41:27 +0100 3355980 http://www.medworm.com/index.php?rid=3355979&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx836p11415203572%2F Conclusions/interpretation  Hyperglycaemia in CP patients is associated with reduced beta cell area. However, reduced beta cell area does not predict the development of diabetes, suggesting that other factors are more important determinants of alterations in glucose metabolism in patients with CP. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1705-0Authors H. Schrader, Ruhr-University Bochum Department of Medicine I, St Josef-Hospital Gudrunstr. 56 44791 Bochum GermanyB. A. Menge, Ruhr-University Bochum Department of Medicine I, St Josef-Hospital Gudrunstr. 56 44791 Bochum GermanyC. Zeidler, Ruhr-University Bochum Department of Medicine I, St Josef-Hospital Gudrunstr. 56 44791 Bochum GermanyP. R. Ritter, Ruhr-University Bochum Department of Medic... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3355979 Wed, 10 Mar 2010 15:41:27 +0100 3355979 http://www.medworm.com/index.php?rid=3355981&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F63u8vtw077513421%2F Conclusions/interpretation  IGR characterised by fasting or post-challenge hyperglycaemia is associated with significant vascular stiffening. Post-challenge glucose and HOMA-IR are the most powerful metabolic predictors of arterial stiffness, implying hyperglycaemic excursion and insulin resistance play important roles in the pathogenesis of arteriosclerosis. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1689-9Authors D. R. Webb, University of Leicester Diabetes and Vascular Research Group, Department of Cardiovascular Sciences Leicester LE1 5WW UKK. Khunti, University of Leicester Department of Health Sciences Leicester UKR. Silverman, University of Leicester Diabetes and Vascular Research Group, Department of Cardiovascular Sciences Leicester L... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3355981 Wed, 10 Mar 2010 15:41:26 +0100 3355981 http://www.medworm.com/index.php?rid=3355982&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmw23556tpjt22656%2F Conclusions/interpretation  These data suggest that in obese youth, independent of age, BMI z score, sex, family history and ethnicity, insulin sensitivity and secretion decline when moving from low to high normal fasting plasma glucose. The simple measure of fasting plasma glucose could assist clinicians in identifying children for targeted diabetes screening and subsequent lifestyle management. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1693-0Authors G. O’Malley, Yale University School of Medicine Department of Pediatrics 330 Cedar Street PO Box 208064 New Haven CT 06520 USAN. Santoro, Yale University School of Medicine Department of Pediatrics 330 Cedar Street PO Box 208064 New Haven CT 06520 USAV. Northrup, Yale Center for Clinical Inv... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3355982 Wed, 10 Mar 2010 15:41:24 +0100 3355982 http://www.medworm.com/index.php?rid=3336644&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8u7466g0g2h8q0qm%2F Conclusion  The expression patterns of miR-222, miR-27a, miR-195, miR-103 and miR-10b varied with hyperglycaemia, suggesting a role for these microRNAs in the pathophysiology of type 2 diabetes, as modelled by the Gyoto–Kakizaki rat. We observed similar patterns of expression of miR-222, miR-27a and miR-29a in adipocytes as a response to increased glucose levels, which supports our hypothesis that altered expression of microRNAs accompanies primary events related to the pathogenesis of type 2 diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1667-2Authors B. M. Herrera, University of Oxford Wellcome Trust Centre for Human Genetics Roosevelt Drive Oxford OX3 7BN UKH. E. Lockstone, University of Oxford Wellcome Trust Centre for Human Genet... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3336644 Wed, 03 Mar 2010 08:52:46 +0100 3336644 http://www.medworm.com/index.php?rid=3328598&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe7364474687h41h6%2F Conclusions/interpretation  Metabolic stress evidenced as low plasma glucose levels appears to be an important determinant for the activation of the MAPK signalling pathway and the transcriptional response of the liver to acute exercise. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1666-3Authors M. Hoene, University Hospital of Tuebingen Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine Otfried-Mueller-Straße 10 D-72076 Tuebingen GermanyH. Franken, University of Tuebingen Wilhelm-Schickard-Institute for Computer Science, Centre for Bioinformatics Tuebingen GermanyL. Fritsche, University Hospital of Tuebingen Division of Endocrinology, Diabetology, Angiology, N... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3328598 Tue, 02 Mar 2010 09:58:43 +0100 3328598 http://www.medworm.com/index.php?rid=3315547&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr275x4uv4915h115%2F Conclusions/interpretation  The age-of-onset distribution showed a shift towards younger ages and was bimodal in the Down’s syndrome group. The better metabolic control found, despite intellectual impairment, in young Down’s syndrome patients with diabetes cannot be conclusively explained by our data, but is likely to be due to a less complex lifestyle. Our data provide further confirmation that coeliac and thyroid antibodies are more prevalent in Down’s syndrome. The presence of beta cell autoantibodies supports an autoimmune cause of diabetes in some children with Down’s syndrome. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1686-zAuthors T. R. Rohrer, Saarland University Hospital Department of Paediatrics and Neonatology Kirrberger ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3315547 Thu, 25 Feb 2010 20:26:07 +0100 3315547 http://www.medworm.com/index.php?rid=3315548&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh06161rr11433138%2F Conclusions/interpretation  These data show that hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation is mediated by increased intracellular methylglyoxal levels in a pathway dependent on oxidative stress. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1677-0Authors O. Brouwers, University Hospital Maastricht Department of Internal Medicine P. Debyelaan 25 P.O. Box 5800 6202 AZ Maastricht the NetherlandsP. M. Niessen, University Hospital Maastricht Department of Internal Medicine P. Debyelaan 25 P.O. Box 5800 6202 AZ Maastricht the NetherlandsG. Haenen, Maastricht University Department of Pharmacology and Toxicology Maastricht the NetherlandsT. Miyata, Tohoku University Centre of Translational and Advanced Research Sendai Jap... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3315548 Thu, 25 Feb 2010 20:26:04 +0100 3315548 http://www.medworm.com/index.php?rid=3313041&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F81715658352m4251%2F Conclusions/interpretation  Sex differences in 2hPG levels after an OGTT may to some extent be a consequence of giving the same amount of glucose to individuals with different body size. In contrast, sex differences in FPG and HbA1c levels are likely to have a true physiological basis. In clinical practice, the HbA1c assay may be more convenient than the OGTT, but it is important to note that different populations are identified by the two methods. Trial registration  ClinicalTrials.gov NCT00289237 Funding  Supported by grants from the Danish Diabetes Association, the Danish Medical Research Council, the Danish Centre for Evaluation and Health Technology Assessment, Novo Nordisk, GlaxoSmithKline, Copenhagen County, The Danish Heart Foundatio... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3313041 Thu, 25 Feb 2010 06:57:18 +0100 3313041 http://www.medworm.com/index.php?rid=3313042&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy720668563761024%2F Conclusions  Folic acid administration reduces neointimal thickening, augments vasa vasorum neoformation and reduces oxidative stress in saphenous vein grafts from diabetic pigs. Folic acid may therefore be particularly effective in reducing vein graft failure in diabetic patients. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1680-5Authors J. Bloor, University of Bristol Department of Vascular Surgery Bristol UKN. Shukla, Bristol Heart Institute, Bristol Royal Infirmary Marlborough Street Bristol BS2 8HW UKF. C. T. Smith, University of Bristol Department of Vascular Surgery Bristol UKG. D. Angelini, Bristol Heart Institute, Bristol Royal Infirmary Marlborough Street Bristol BS2 8HW UKJ. Y. Jeremy, Bristol Heart Institute, Bristol Royal Infirmary... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3313042 Thu, 25 Feb 2010 06:57:17 +0100 3313042 http://www.medworm.com/index.php?rid=3313043&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F441413412608848u%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-010-1688-xAuthors K. N. Frayn, University of Oxford Oxford Centre for Diabetes, Endocrinology and Metabolism Churchill Hospital Oxford OX3 7LJ UKL. Hodson, University of Oxford Oxford Centre for Diabetes, Endocrinology and Metabolism Churchill Hospital Oxford OX3 7LJ UKF. Karpe, University of Oxford Oxford Centre for Diabetes, Endocrinology and Metabolism Churchill Hospital Oxford OX3 7LJ UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3313043 Thu, 25 Feb 2010 06:46:43 +0100 3313043 http://www.medworm.com/index.php?rid=3313045&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk8588017367m5169%2F Abstract  Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the majority of patients. Amyloid formation is considered a significant factor in deterioration of islet function and reduction in beta cell mass, and involves aggregation of monomers of the normally soluble beta cell peptide, human islet amyloid polypeptide (hIAPP) into oligomers, fibrils and, ultimately, mature amyloid deposits. Despite extensive in vitro studies, the process of hIAPP aggregation in vivo is poorly understood, though it is widely reported to promote cytotoxicity. Recently, studies have suggested that only the early stages of fibril assembly, and in particular small hIAPP oligomers, are responsible for beta cell cytotoxicity. This challenges the prior concept that ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3313045 Thu, 25 Feb 2010 06:46:42 +0100 3313045 http://www.medworm.com/index.php?rid=3313044&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu93426371735k515%2F Conclusions/interpretation  Increasing serum concentrations of individual POPs considerably increased prevalence of prediabetes and diabetes in a dose-dependent manner. Interaction of industrial and agricultural pollutants in increasing prevalence of prediabetes or diabetes is likely. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1683-2Authors J. Ukropec, Institute of Experimental Endocrinology (an EU Centre of Excellence) Slovak Academy of Sciences Diabetes Laboratory Vlarska 3 83306 Bratislava Slovak RepublicZ. Radikova, Institute of Experimental Endocrinology (an EU Centre of Excellence) Slovak Academy of Sciences Laboratory of Human Endocrinology Bratislava Slovak RepublicM. Huckova, Institute of Experimental Endocrinology (an EU Centre of Exc... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3313044 Thu, 25 Feb 2010 06:46:42 +0100 3313044 http://www.medworm.com/index.php?rid=3313046&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft237541g78424762%2F Conclusions/interpretation  Our results suggest that all tested insulin compounds may stimulate tumour growth by enhancing local angiogenesis. Future studies need to confirm the association between insulin therapy in type 2 diabetes and tumour progression. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-010-1687-yAuthors K. L. Rensing, Academic Medical Center/University of Amsterdam Department of Vascular Medicine Meibergdreef 9 1105 AZ Amsterdam the NetherlandsF. M. Houttuijn Bloemendaal, Academic Medical Center/University of Amsterdam Department of Vascular Medicine Meibergdreef 9 1105 AZ Amsterdam the NetherlandsE. M. Weijers, VU University Medical Center Institute for Cardiovascular Research, Laboratory for Physiology Amsterdam the Nethe... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3313046 Thu, 25 Feb 2010 06:46:35 +0100 3313046 http://www.medworm.com/index.php?rid=3308545&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9636136086628577%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-010-1690-3Authors K. Buschard, Bartholin Instituttet Rigshospitalet section 3733, Blegdamsvej 9 DK-2100 Copenhagen Denmark Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3308545 Wed, 24 Feb 2010 06:51:39 +0100 3308545 http://www.medworm.com/index.php?rid=3308546&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg38083228181u180%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-010-1674-3Authors K. Müller, University of Leipzig Department of Internal Medicine, Division of Endocrinology and Nephrology Liebigstr. 18 04103 Leipzig GermanyC. Weidinger, University of Leipzig Department of Internal Medicine, Division of Endocrinology and Nephrology Liebigstr. 18 04103 Leipzig GermanyD. Führer, University of Leipzig Department of Internal Medicine, Division of Endocrinology and Nephrology Liebigstr. 18 04103 Leipzig Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3308546 Wed, 24 Feb 2010 06:51:38 +0100 3308546 http://www.medworm.com/index.php?rid=3304178&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw3k79v31w722kuj4%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-010-1679-yAuthors A. J. Farmer, University of Oxford Division of Public Health and Primary Care Rosemary Rue Building, Old Road Campus, Headington Oxford OX3 7LF UKD. S. Lasserson, University of Oxford Division of Public Health and Primary Care Rosemary Rue Building, Old Road Campus, Headington Oxford OX3 7LF UKR. R. Holman, University of Oxford Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism Oxford UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3304178 Tue, 23 Feb 2010 07:40:45 +0100 3304178 http://www.medworm.com/index.php?rid=3304179&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl714722041284l14%2F Abstract  Four reports in Diabetologia presented data on the association between hypoglycaemic agents and the risk of cancer. One study showed a higher risk of cancer overall in subjects with diabetes receiving insulin or sulfonylureas than in those on metformin. In another study, the risk of cancer overall increased with dose for any type of insulin and, among high doses, insulin glargine (A21Gly,B31Arg,B32Arg human insulin)-only users had a higher risk than subjects on human insulin. In two studies, users of insulin glargine alone had a higher risk of breast cancer than those on other insulins, a third study found no association. Whether these associations are causal or at least partially explained by chance or biases such as confounding, reverse causation, selection or de... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3304179 Tue, 23 Feb 2010 07:40:40 +0100 3304179 http://www.medworm.com/index.php?rid=3289276&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkw178008612g671l%2F Conclusions/interpretation  In this work we show that glucosamine-induced ER stress causes insulin resistance in both human and rat myotubes and impairs GLUT4 production and insulin-induced glucose uptake via an ATF6-dependent decrease of the GLUT4 regulators MEF2A and PGC1α. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1676-1Authors G. A. Raciti, Università di Napoli Federico II Dipartimento di Biologia e Patologia Cellulare e Molecolare Via Sergio Pansini, 5 Naples 80131 ItalyC. Iadicicco, Università di Napoli Federico II Dipartimento di Biologia e Patologia Cellulare e Molecolare Via Sergio Pansini, 5 Naples 80131 ItalyL. Ulianich, Università di Napoli Federico II Dipartimento di Biologia e Patologia Cellulare e Molecolare Via Sergio Pansi... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3289276 Thu, 18 Feb 2010 06:49:21 +0100 3289276 http://www.medworm.com/index.php?rid=3285402&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvll7748002177563%2F Conclusions/interpretation  The results indicated that local oxidative stress that has a neurodegenerative influence in the diabetic retina is prevented by constant intake of a lutein-supplemented diet. The antioxidant, lutein may be a potential therapeutic approach to protect visual function in diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1655-6Authors M. Sasaki, Keio University School of Medicine Laboratory of Retinal Cell Biology Tokyo JapanY. Ozawa, Keio University School of Medicine Laboratory of Retinal Cell Biology Tokyo JapanT. Kurihara, Keio University School of Medicine Laboratory of Retinal Cell Biology Tokyo JapanS. Kubota, Keio University School of Medicine Laboratory of Retinal Cell Biology Tokyo JapanK. Yuki, Keio Univer... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3285402 Wed, 17 Feb 2010 07:26:13 +0100 3285402 http://www.medworm.com/index.php?rid=3281247&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw0533l808uu21530%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-010-1678-zAuthors A. M. Wägner, Complejo Hospitalario Universitario Insular Materno-Infantil Department of Endocrinology and Nutrition Av. Marítima del sur s/n Las Palmas de Gran Canaria 35016 SpainD. Mauricio, Hospital Universitari Arnau de Vilanova Department of Endocrinology and Nutrition Lleida Spain Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3281247 Tue, 16 Feb 2010 07:18:44 +0100 3281247 http://www.medworm.com/index.php?rid=3281248&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm347153426223j33%2F Conclusions/interpretation  Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1681-4Authors A. P. Kengne, University of Sydney The George Institute for International Health PO Box M201 Level 10 KGV Building, RPAH, Missenden Road, Camperdown Sydney NSW 2050 AustraliaA. Patel, University of Sydney The George Institute for International Health PO Box M201 Level 10 KGV Building, RPAH, Missenden Road, Camperdown Sydney NSW 2050 AustraliaS. Colagiuri, The University of Sydney Institute of Obesity, Nutrition and Exercise, Faculty of Medicine Sydney NSW AustraliaS. Hell... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3281248 Tue, 16 Feb 2010 07:18:43 +0100 3281248 http://www.medworm.com/index.php?rid=3270479&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4277160u612667x%2F Conclusions/interpretation  These results show that PKCδ plays a key role in the inflammatory effect of IL-6 in adipose cells and may be a suitable target for novel anti-inflammatory agents. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1668-1Authors E. Wallerstedt, The Sahlgrenska Academy at University of Gothenburg The Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine/Diabetes Blå Stråket 5 SE-413 45 Gothenburg SwedenU. Smith, The Sahlgrenska Academy at University of Gothenburg The Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine/Diabetes Bl... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3270479 Fri, 12 Feb 2010 07:06:06 +0100 3270479 http://www.medworm.com/index.php?rid=3264222&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32278w8715575073%2F Conclusions/interpretation  In older men, BMI and WC yielded similar prediction of risk of type 2 diabetes, whereas WC was clearly a superior predictor in older women. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1670-7Authors S. G. Wannamethee, University College London Medical School Department of Primary Care and Population Health Hampstead Campus, Rowland Hill St London NW3 2PF UKO. Papacosta, University College London Medical School Department of Primary Care and Population Health Hampstead Campus, Rowland Hill St London NW3 2PF UKP. H. Whincup, St George’s, University of London Department of Community Health Sciences London UKC. Carson, London School of Health and Tropical Medicine Non-Communicable Disease Epidemiology Unit, Department of E... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3264222 Wed, 10 Feb 2010 06:52:39 +0100 3264222 http://www.medworm.com/index.php?rid=3264223&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F508667p3k4625375%2F Conclusions/interpretation  Among diabetic patients hospitalised with SSTI from 2003 to 2007, only MRSA increased in prevalence. Patients with non-foot (vs foot) infections were more severely ill. Independent risk factors for increased mortality rates, length of stay and costs included more severe illness, transfer from another hospital and wound cultures with Pseudomonas or other gram-negatives. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1672-5Authors B. A. Lipsky, University of Washington VA Puget Sound Health Care System, General Internal Medicine (S-111-PCC) 1660 S. Columbian Way Seattle WA USAY. P. Tabak, CareFusion Clinical Research Marlborough MA USAR. S. Johannes, CareFusion Clinical Research Marlborough MA USAL. Vo, Ortho-McNeil Janssen... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3264223 Wed, 10 Feb 2010 06:47:26 +0100 3264223 http://www.medworm.com/index.php?rid=3264224&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv607567976353636%2F Conclusions/interpretation  Our results indicate that 2 h glucose strongly confounds the prospective association between fasting NEFA and diabetes; carefully adjusted fasting NEFA levels are inversely associated with diabetes risk. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1657-4Authors D. Il’yasova, Duke University Medical Center Department of Community and Family Medicine, Prevention Research Division Box 2949 Durham NC 27710 USAF. Wang, Duke University Medical Center Department of Community and Family Medicine, Prevention Research Division Box 2949 Durham NC 27710 USAR. B. D’Agostino, Wake Forest University School of Medicine Public Health Sciences Winston-Salem NC USAA. Hanley, University of Toronto Department of Nutritional Sciences... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3264224 Tue, 09 Feb 2010 06:52:03 +0100 3264224 http://www.medworm.com/index.php?rid=3247941&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj873p6u1v465125u%2F Conclusions/interpretation  Screening for pre-diabetes followed by diet and exercise, or metformin treatment is cost-effective and should be considered for incorporation into current practice. The number of dietitians and exercise physiologists needed to deliver such lifestyle change interventions will need to be increased to appropriately support the intervention. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1661-8Authors M. Y. Bertram, The University of Queensland Centre for Burden of Disease and Cost-Effectiveness, School of Population Health Herston Rd Herston Queensland 4006 AustraliaS. S. Lim, The University of Washington Centre for Health Metrics and Evaluation Seattle WA USAJ. J. Barendregt, The University of Queensland Centre for Burden o... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3247941 Thu, 04 Feb 2010 18:08:18 +0100 3247941 http://www.medworm.com/index.php?rid=3241249&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F617105711481m231%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-010-1665-4Authors H. Osawa, Ehime University Graduate School of Medicine Department of Molecular and Genetic Medicine Shitsukawa Toon Ehime 791-0295 JapanY. Tabara, Ehime University Graduate School of Medicine Department of Basic Medical Research and Education Toon Ehime JapanJ. Ohashi, University of Tsukuba Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences Tsukuba Ibaraki JapanR. Kawamura, Ehime University Graduate School of Medicine Department of Molecular and Genetic Medicine Shitsukawa Toon Ehime 791-0295 JapanH. Onuma, Ehime University Graduate School of Medicine Department of Molecular and Genetic Medicine Shitsukawa Toon Ehime 791-0295 JapanH. Makino, Ehime University Gr... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3241249 Wed, 03 Feb 2010 17:54:14 +0100 3241249 http://www.medworm.com/index.php?rid=3241250&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq6757u5403j65888%2F Conclusions/interpretation  Adipose tissue enriched with palmitic acid and depleted of essential PUFAs is associated with insulin resistance. The positive association between minor SFAs and insulin sensitivity merits further investigation. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1669-0Authors D. Iggman, Uppsala University Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism Uppsala SwedenJ. Ärnlöv, Högskolan Dalarna Department of Health and Social Sciences Falun SwedenB. Vessby, Uppsala University Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism Uppsala SwedenT. Cederholm, Uppsala University Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism Upps... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3241250 Wed, 03 Feb 2010 07:59:36 +0100 3241250 http://www.medworm.com/index.php?rid=3241251&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F80nhn7m427448808%2F Conclusions/interpretation  There is a substantial increase in risk of LEA associated with glycaemia in individuals with diabetes. In the absence of conclusive evidence from trials, this paper provides further epidemiological support for glucose-lowering as a strategy to reduce amputation in a population without acute foot ulceration or former amputation; it also provides disease modellers with estimates to assess the overall burden of hyperglycaemia. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1638-7Authors A. I. Adler, Addenbrooke’s Hospital, Cambridge University Foundation Hospital Trust Wolfson Diabetes and Endocrine Clinic, Institute of Metabolic Sciences Box 281 Hills Road Cambridge CB2 2QQ UKS. Erqou, University of Cambridge Department... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3241251 Wed, 03 Feb 2010 07:59:35 +0100 3241251 http://www.medworm.com/index.php?rid=3241252&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk0m611557m735k34%2F Content Type Journal ArticleCategory Book ReviewDOI 10.1007/s00125-010-1664-5Authors V. Jörgens, EASD/EFSD Rheindorfer Weg 3 40591 Düsseldorf Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3241252 Tue, 02 Feb 2010 06:57:20 +0100 3241252 http://www.medworm.com/index.php?rid=3228990&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu12365q247p8r372%2F Content Type Journal ArticleDOI 10.1007/BF03180172 Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X Journal Volume Volume 44 Journal Issue Volume 44, Supplement 1 / August, 2001 (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3228990 Fri, 29 Jan 2010 12:05:42 +0100 3228990 http://www.medworm.com/index.php?rid=3228989&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F426u77412v837864%2F Content Type Journal ArticleDOI 10.1007/BF03180171 Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X Journal Volume Volume 44 Journal Issue Volume 44, Supplement 1 / August, 2001 (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3228989 Fri, 29 Jan 2010 12:05:42 +0100 3228989 http://www.medworm.com/index.php?rid=3228988&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcj8554x602231432%2F Content Type Journal ArticleDOI 10.1007/BF03180170 Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X Journal Volume Volume 44 Journal Issue Volume 44, Supplement 1 / August, 2001 (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3228988 Fri, 29 Jan 2010 12:05:42 +0100 3228988 http://www.medworm.com/index.php?rid=3224029&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx452n3u891g1w181%2F Conclusions/interpretation  Our data suggest that metabolic disorders in SGA individuals are amplified by the weight gain with time when adults, both probably resulting from fetal programming. Moreover, the modest increase in IR contrasts with the constant and much higher prevalence of MS. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1650-yAuthors T. Meas, Hôpital Robert Debré INSERM Unité U690 48 Boulevard Sérurier 75019 Paris FranceS. Deghmoun, Hôpital Robert Debré INSERM Unité U690 48 Boulevard Sérurier 75019 Paris FranceC. Alberti, Université Paris Paris FranceE. Carreira, Hôpital Robert Debré INSERM Unité U690 48 Boulevard Sérurier 75019 Paris FranceP. Armoogum, AP-HP, Hôpital Robert Debré Unité d’Epidémiologie Clinique Par... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3224029 Thu, 28 Jan 2010 17:58:40 +0100 3224029 http://www.medworm.com/index.php?rid=3214061&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2453600wtp17485%2F Content Type Journal ArticleCategory Research LetterDOI 10.1007/s00125-010-1660-9Authors E. Esmatjes, Hospital Clinic Universitari Diabetes Unit C/Villarroel 170 08036 Barcelona SpainX. Montaña, Hospital Clinic Universitari Interventional Angioradiology Unit Barcelona SpainM. I. Real, Hospital Clinic Universitari Interventional Angioradiology Unit Barcelona SpainJ. Blanco, Hospital Clinic Universitari Diabetes Unit C/Villarroel 170 08036 Barcelona SpainI. Conget, Hospital Clinic Universitari Diabetes Unit C/Villarroel 170 08036 Barcelona SpainR. Casamitjana, Hospital Clinic Universitari Biochemistry and Molecular Genetics Department Barcelona SpainM. Rovira, Hospital Clinic Universitari Bone Marrow Transplant Unit Barcelona SpainR. Gomis, Hospital Clinic Universitari Diabetes Unit C/V... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3214061 Tue, 26 Jan 2010 07:09:51 +0100 3214061 http://www.medworm.com/index.php?rid=3214062&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe0t7g51082645021%2F Abstract  Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide. The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of energy expenditure through decreased physical activity. In addition, recent studies have focused on intestinal microbiota as environmental factors that increase energy yield from diet, regulate peripheral metabolism and thereby increase body weight. Obesity is associated with substantial changes in composition and metabolic function of gut microbiota, but the pathophysiological processes driving this bidirectional relationship have not been fully elucidated. This review discusses the relationships between the followin... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3214062 Tue, 26 Jan 2010 07:09:50 +0100 3214062 http://www.medworm.com/index.php?rid=3214063&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F308t7v12101m0537%2F Conclusions/interpretation  These aggregates were superior to intact islets in terms of survival and function in low-oxygen culture and during transplantation and are likely to provide more efficient utilisation of islet tissue, a finding of importance for the future of cell therapy for diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1653-8Authors E. S. O’Sullivan, Joslin Diabetes Center Section on Islet Transplantation and Cell Biology, Research Division One Joslin Place Boston MA 02215 USAA. S. Johnson, Massachusetts Institute of Technology Department of Chemical Engineering Cambridge MA USAA. Omer, Joslin Diabetes Center Section on Islet Transplantation and Cell Biology, Research Division One Joslin Place Boston MA 02215 USAJ. Holliste... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3214063 Tue, 26 Jan 2010 07:02:41 +0100 3214063 http://www.medworm.com/index.php?rid=3206140&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1720634386457gw6%2F Conclusions/interpretation  Liver fat, more than visceral fat, strongly increases when glycaemia and glucose tolerance move from NGT to isolated IFG, isolated IGT and IFG+IGT. Because liver-derived circulating fetuin-A determines, although weakly, prediabetes categories, it is worth searching for hepatokines more strongly predicting prediabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1663-6Authors K. Kantartzis, University of Tübingen Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry Otfried-Müller-Str. 10 72076 Tübingen GermanyJ. Machann, University of Tübingen Section of Experimental Radiology Tübingen GermanyF. Schick, University of Tübingen Section of Exper... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3206140 Sat, 23 Jan 2010 07:58:24 +0100 3206140 http://www.medworm.com/index.php?rid=3206141&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq1g73215w5885q98%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1654-7Authors L. G. Hemkens, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Straße 27 51105 Cologne GermanyU. Grouven, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Straße 27 51105 Cologne GermanyR. Bender, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Straße 27 51105 Cologne GermanyP. T. Sawicki, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Straße 27 51105 Cologne Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3206141 Sat, 23 Jan 2010 07:58:22 +0100 3206141 http://www.medworm.com/index.php?rid=3195313&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx372378u3434321l%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1656-5Authors P. D. Home, Newcastle University ICM-Diabetes, The Medical School Framlington Place Newcastle upon Tyne NE2 4HH UKP. Lagarenne, sanofi-aventis Pharmacovigilance & Epidemiology Bridgewater NJ USA Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3195313 Tue, 19 Jan 2010 06:52:23 +0100 3195313 http://www.medworm.com/index.php?rid=3195312&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F76581j97u3431pw3%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-010-1659-2Authors K. Borch-Johnsen, Steno Diabetes Center Niels Steensensvej 2 DK 2820 Gentofte DenmarkN. Wareham, Addenbrooke’s Hospital MRC Epidemiology Unit, Institute of Metabolic Science Cambridge UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3195312 Tue, 19 Jan 2010 06:52:23 +0100 3195312 http://www.medworm.com/index.php?rid=3195314&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6v5212468h87544%2F Conclusions/interpretation  This first randomised controlled trial to test an intervention to prevent glycaemic relapse found that regularly scheduled telephone contact by a nurse practitioner was no more effective than routine follow-up care in preventing glycaemic relapse. Trial registration:  ClinicalTrials.gov NCT00362193 Funding:  The research was supported by the National Institute of Diabetes and Digestive and Kidney Disease R18 DK 062258, P60 DK 020593 and K24 DK 077875. M. M. Huizinga was supported by National Institute of Environmental Health Sciences 1 K12 ES 015855 and National Center for Research Resources 5 K12 RR 023266. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1658-3Authors M. M. Huizinga, Joh... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3195314 Tue, 19 Jan 2010 06:52:20 +0100 3195314 http://www.medworm.com/index.php?rid=3195315&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh01g2762107n3050%2F Conclusions/interpretation  These findings demonstrate that perturbations in amino acid homeostasis, but not inflammatory markers or NEFAs, are associated with IR in individuals of relatively low body mass. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1637-8Authors E. S. Tai, National University of Singapore Department of Medicine, Yong Loo Lin School of Medicine Singapore Republic of SingaporeM. L. S. Tan, Singapore Health Services Singapore Republic of SingaporeR. D. Stevens, Duke Independence Park Facility Sarah W. Stedman Nutrition and Metabolism Center 4321 Medical Park Drive, Suite 200 Durham NC 27704 USAY. L. Low, Singapore Institute of Clinical Sciences Singapore Republic of SingaporeM. J. Muehlbauer, Duke Independence Park Facility Sarah W... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3195315 Fri, 15 Jan 2010 07:00:45 +0100 3195315 http://www.medworm.com/index.php?rid=3195316&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F15v42j5720kr3l67%2F Conclusions/interpretation  Our algorithm was able to stratify which patients had a low, intermediate or high risk of myocardial ischaemia based on MPS. However, the algorithm had low sensitivity and specificity, combined with high cost and time requirements. Trial registration:  clinicaltrials.gov NCT00298844 Funding:  The study was funded by the Danish Cardiovascular Research Academy (DaCRA), The Danish Diabetes Association and The Danish Heart Foundation. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1646-7Authors M. K. Poulsen, Odense University Hospital Department of Endocrinology Kløvervænget 6, 5th floor 5000 Odense C DenmarkJ. E. Henriksen, Odense University Hospital Department of Endocrinology Kløvervæ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3195316 Fri, 15 Jan 2010 00:49:34 +0100 3195316 http://www.medworm.com/index.php?rid=3195317&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8p46227914616448%2F Conclusions/interpretation  Fasting blood glucose, HbA1c and the presence of diabetes are associated with the severity and progression of coronary atherosclerosis. These observations support the hypothesis that better glycaemic control may favourably influence CAD in patients with abnormal glucose tolerance or diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1651-xAuthors C. Berry, Montreal Heart Institute and Université de Montréal 5000 Belanger Street Montreal QC H1T 1C8 CanadaS. Noble, Montreal Heart Institute and Université de Montréal 5000 Belanger Street Montreal QC H1T 1C8 CanadaJ. C. Grégoire, Montreal Heart Institute and Université de Montréal 5000 Belanger Street Montreal QC H1T 1C8 CanadaR. Ibrahim, Montreal Heart Institute... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3195317 Fri, 15 Jan 2010 00:49:33 +0100 3195317 http://www.medworm.com/index.php?rid=3177236&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp3572576j25l2640%2F Conclusions/interpretation  A 6 day ChAglyCD3 treatment can suppress the rise in insulin requirements of recent-onset type 1 diabetic patients over 48 months, depending on their age and initial residual beta cell function. In younger patients this effect is associated with reduced deterioration of metabolic variables. These observations help to define inclusion criteria for prevention trials. Trial registration:  ClinicalTrials.gov NCT00627146 Funding:  Center grants from the Juvenile Diabetes Research Foundation (4-2001-434, 4-2005-1327) and grants from the Belgian Fund for Scientific Research-Flanders and from Brussels Free University-VUB. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1644-9Authors B. ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3177236 Wed, 13 Jan 2010 17:51:29 +0100 3177236 http://www.medworm.com/index.php?rid=3169020&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7m6t7131772pj144%2F Abstract  Continuous subcutaneous glucose monitoring (CGM) is a developing technology in the treatment of diabetes mellitus. The first randomised controlled trials on its efficacy have been performed. In several studies, CGM lowered HbA1c in adult patients with suboptimally controlled type 1 diabetes mellitus, when selecting compliant patients who tolerate the device. However, as a preventive tool for hypoglycaemia, CGM has not fulfilled the great expectations. Increasing reimbursement of CGM is expected in the near future, awaiting studies on cost-effectiveness. Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1649-4Authors J. Hermanides, Academic Medical Centre Department of Internal Medicine P.O. Box 22660 1100 DD Amsterdam the NetherlandsJ. H. De... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3169020 Sun, 10 Jan 2010 07:12:07 +0100 3169020 http://www.medworm.com/index.php?rid=3169021&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx104634mlp37gjm2%2F Conclusions/interpretation  Tissue kallikrein levels are increased in type 2 diabetes, whereas statin therapy does not modify the circulating kallikrein–kinin system. Cardiac tissue kallikrein may play a greater cardioprotective role in type 2 diabetic than in non-diabetic patients and contribute to the benefits of ACE inhibitor therapy in type 2 diabetic patients. However, our findings do not support a role for the kallikrein–kinin system in mediating the effects of statin therapy on endothelial function. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1645-8Authors D. J. Campbell, St Vincent’s Institute of Medical Research 41 Victoria Parade Fitzroy Victoria 3065 AustraliaA. Kladis, St Vincent’s Institute of Medical Research 41 Victoria Pa... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3169021 Sun, 10 Jan 2010 07:12:03 +0100 3169021 http://www.medworm.com/index.php?rid=3169022&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn13140241v40k546%2F Conclusions/interpretation  Children who are heavier at birth have a significant and consistent, but relatively small increase in risk of type 1 diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1648-5Authors C. R. Cardwell, Queen’s University Belfast Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences Grosvenor Road Belfast BT12 6BJ UKL. C. Stene, Norwegian Institute of Public Health Division of Epidemiology Oslo NorwayG. Joner, Oslo University Hospital Oslo Diabetes Research Centre Oslo NorwayE. A. Davis, The University of Western Australia Telethon Institute for Child Health Research, Centre for Child Health Research Perth WA AustraliaO. Cinek, Charles University The 2nd Medical School Prague Czech RepublicJ. Ro... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3169022 Sun, 10 Jan 2010 07:12:00 +0100 3169022 http://www.medworm.com/index.php?rid=3161016&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy10n327j46567tp7%2F Conclusions/interpretation  Our data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival, possibly reflecting different subsets of type 1 diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1642-yAuthors R. Gianani, University of Colorado Denver Barbara Davis Center for Childhood Diabetes 1775 Aurora Court Aurora CO 80055 USAM. Campbell-Thompson, University of Florida at Gainesville Department of Pathology Gainesville FL USAS. A. Sarkar, University of Colorado Denver Barbara Davis Center for Childhood Diabetes 1775 Aurora Court Aurora CO 80055 USAC. Wasserfall, University of Florida at Gainesville Department of Pathology Gainesville FL USAA. Pugliese, The Diabet... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3161016 Sat, 09 Jan 2010 08:32:13 +0100 3161016 http://www.medworm.com/index.php?rid=3161017&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8m88p71454t7t52%2F Conclusions/interpretation  Insulin resistance normally upregulates the secretory tone, with no evidence of defective compensation in IGR. In contrast, beta cell glucose sensitivity is independent of insulin resistance, but a key determinant of glucose tolerance. This suggests that hyperglycaemia results from an intrinsic beta cell defect rather than from inadequate compensation for insulin resistance. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1647-6Authors A. Mari, ISIB-CNR Corso Stati Uniti 4 35127 Padua ItalyA. Tura, ISIB-CNR Corso Stati Uniti 4 35127 Padua ItalyA. Natali, University of Pisa School of Medicine Department of Internal Medicine and C.N.R. Institute of Clinical Physiology Pisa ItalyM. Laville, Lyon 1 University CRNHRA Hospices C... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3161017 Sat, 09 Jan 2010 08:32:12 +0100 3161017 http://www.medworm.com/index.php?rid=3161018&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmk24815668350452%2F Conclusions/interpretation  Metformin reduces insulin-dose requirement in type 1 diabetes but it is unclear whether this is sustained beyond 1 year and whether there are benefits for cardiovascular and other key clinical outcomes. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00125-009-1636-9Authors S. Vella, University of Dundee Biomedical Research Institute, Ninewells Hospital and Medical School Dundee DD1 9SY UKL. Buetow, University of Dundee Biomedical Research Institute, Ninewells Hospital and Medical School Dundee DD1 9SY UKP. Royle, University of Aberdeen Department of Public Health, School of Medicine Aberdeen UKS. Livingstone, University of Dundee Biomedical Research Institute, Ninewells Hospital and Medical School Dundee DD1 9SY UKH. M. Colhoun,... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3161018 Fri, 08 Jan 2010 09:07:49 +0100 3161018 http://www.medworm.com/index.php?rid=3161019&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F47472609h1508j46%2F Conclusions/interpretation  These studies establish that GLP-1R signalling may regulate lymphocyte proliferation and maintenance of peripheral regulatory T cells. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1643-xAuthors I. Hadjiyanni, Mt Sinai Hospital Department of Medicine, Samuel Lunenfeld Research Institute 600 University Avenue TCP5-1004 Toronto ON M5G 1X5 CanadaK. A. Siminovitch, Mt Sinai Hospital Department of Medicine, Samuel Lunenfeld Research Institute 600 University Avenue TCP5-1004 Toronto ON M5G 1X5 CanadaJ. S. Danska, University of Toronto Department of Immunology, Hospital for Sick Children Toronto ON CanadaD. J. Drucker, Mt Sinai Hospital Department of Medicine, Samuel Lunenfeld Research Institute 600 University Avenue TCP5-1004 T... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3161019 Thu, 07 Jan 2010 22:27:18 +0100 3161019 http://www.medworm.com/index.php?rid=3161020&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd47864t66r0n1gmq%2F Conclusions/interpretation  These findings suggest that lifestyle modification had limited effects on most typical control variables, but did have a significant effect on stroke incidence in patients with established type 2 diabetes. Clinical Trial Registration: UMIN-CTR C000000222 Funding: The Ministry of Health, Labour and Welfare, Japan Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1622-2Authors H. Sone, University of Tsukuba Institute of Clinical Medicine Department of Internal Medicine 1-1-1 Tennodai Tsukuba Ibaraki Japan 305-8575S. Tanaka, Tokyo University of Science Laboratory of Biostatistics Tokyo JapanS. Iimuro, University of Tokyo School of Medicine Department of Biostatistics Tokyo JapanS. Tanaka, Kyoto University Trans... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3161020 Thu, 07 Jan 2010 16:11:11 +0100 3161020 http://www.medworm.com/index.php?rid=3154554&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk55273uu78458j61%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1652-9Authors P. M. Humpert, University of Heidelberg Department of Medicine I and Clinical Chemistry Im Neuenheimer Feld 410 69120 Heidelberg Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3154554 Wed, 06 Jan 2010 06:47:58 +0100 3154554 http://www.medworm.com/index.php?rid=3154555&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F36780w3544r5m541%2F Conclusions/interpretation  Enrolment in a supervised aerobic exercise intervention led to weight loss, increased fitness and improvements in some but not all metabolic outcomes. In appropriately screened older individuals, such interventions appear to be safe. Trial registration:  Controlled-trials.com ISRCTN60986572 Funding:  Medical Research Council Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1641-zAuthors F. M. Finucane, Addenbrooke’s Hospital MRC Epidemiology Unit, Institute of Metabolic Science Box 285 Hills Road Cambridge CB2 0QQ UKS. J. Sharp, Addenbrooke’s Hospital MRC Epidemiology Unit, Institute of Metabolic Science Box 285 Hills Road Cambridge CB2 0QQ UKL. R. Purslow, Addenbrooke’s Hospital MRC... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3154555 Wed, 06 Jan 2010 06:47:57 +0100 3154555 http://www.medworm.com/index.php?rid=3154556&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc172144176588243%2F Abstract  In recent years, several alternative dietary approaches, including high-protein and low-glycaemic-load diets, have produced faster rates of weight loss than traditional low-fat, high-carbohydrate diets. These diets share an under-recognised unifying mechanism: the reduction of postprandial glycaemia and insulinaemia. Similarly, some food patterns and specific foods (potatoes, white bread, soft drinks) characterised by hyperglycaemia are associated with higher risk of adiposity and type 2 diabetes. Profound compensatory hyperinsulinaemia, exacerbated by overweight, occurs during critical periods of physiological insulin resistance such as pregnancy and puberty. The dramatic rise in gestational diabetes and type 2 diabetes in the young may therefore be traced to foo... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3154556 Tue, 05 Jan 2010 07:28:13 +0100 3154556 http://www.medworm.com/index.php?rid=3134463&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F10031u2131473x81%2F Conclusions/interpretation  Although lower birthweight is an independent risk factor for gestational diabetes mellitus, weight gain since early adulthood, and overall and central obesity in adulthood were more strongly associated with elevated risk of the condition independently of other known risk factors. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1634-yAuthors E. H. Yeung, Eunice Kennedy Shriver National Institute of Child Health and Human Development Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research 6100 Executive Blvd, 7B03 Bethesda MD 20892 USAF. B. Hu, Harvard School of Public Health Departments of Nutrition and Epidemiology Boston MA USAC. G. Solomon, Brigham and Women’s Hospital and Harvard Medical Sch... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3134463 Wed, 30 Dec 2009 16:43:14 +0100 3134463 http://www.medworm.com/index.php?rid=3134465&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8334t37l8rq10111%2F Conclusions/interpretation  We show for the first time in human adipocytes that biguanides and thiazolidinediones activate AMP-activated protein kinase, thus counteracting lipolysis induced by lipolytic agents. In addition, β-agonist- or ANP-stimulated lipolysis increases AMP-activated protein kinase activity. This is because of an increase in the AMP/ATP ratio, linked to activation of some of the released fatty acids into acyl-CoA. AMP-activated protein kinase activation could represent a physiological means of avoiding a deleterious drain of energy during lipolysis but could be used to restrain pharmacological release of fatty acids. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1639-6Authors O. Bourron, INSERM, UMR-S 872 Centre de Recherche d... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3134465 Wed, 30 Dec 2009 16:43:12 +0100 3134465 http://www.medworm.com/index.php?rid=3134464&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F804657v586648m52%2F Conclusions/interpretation  Compared with Pro/Pro individuals, PPARG Ala carriers experienced greater improvements in glucose and insulin metabolism in response to regular endurance training. However, we did not find evidence of association between type 2 diabetes susceptibility variants recently identified through GWAS and glucose homeostasis response to exercise. Our results extend those of previous studies showing that Ala carriers appear to be more responsive to beneficial health effects of lifestyle interventions. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1630-2Authors S.-M. Ruchat, PEPS—Laval University Department of Social and Preventive Medicine 2300 rue de la Terrasse Quebec QC Canada G1V 0A6T. Rankinen, Pennington Biomedical Resear... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3134464 Wed, 30 Dec 2009 16:43:12 +0100 3134464 http://www.medworm.com/index.php?rid=3122780&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F913661618717902l%2F Conclusions/interpretation  Our results indicate that FOXO1 may negatively regulate beta cell differentiation in the human fetal pancreas by controlling critical transcription factors, including NGN3 and NKX6-1. These data suggest that the manipulation of FOXO1 levels may be a useful tool for improving cell-based strategies for the treatment of diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1632-0Authors M. Al-Masri, University of Western Ontario Children’s Health Research Institute London ON CanadaM. Krishnamurthy, University of Western Ontario Children’s Health Research Institute London ON CanadaJ. Li, University of Western Ontario Children’s Health Research Institute London ON CanadaG. F. Fellows, University of Western Ontario Dep... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3122780 Thu, 24 Dec 2009 19:54:34 +0100 3122780 http://www.medworm.com/index.php?rid=3122781&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1q35054242705783%2F Conclusions/interpretation  The significant correlation between expression of a unique splicing form of TCF7L2, named here TCF7L2-NE, and CART, the gene for an anorexigenic neurohormone expressed in the central and peripheral nervous system, suggests that these transcripts may share neuroendocrine functions important for brain, gut and pancreatic islets. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1640-0Authors L. Prokunina-Olsson, National Institutes of Health Laboratory of Translational Genomics, National Cancer Institute 8717 Grovemont Circle Bethesda 20892-4605 MD USAJ. L. Hall, University of Minnesota Lillehei Heart Institute, Department of Medicine, The Developmental Biology Center Minneapolis MN USA Journal DiabetologiaOn... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3122781 Thu, 24 Dec 2009 19:54:33 +0100 3122781 http://www.medworm.com/index.php?rid=3106012&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl76vt833h614170g%2F Conclusion/interpretation  The onset of type 1 diabetes in young adults has long-term detrimental consequences on earnings that cannot be attributed to confounders. Content Type Journal ArticleDOI 10.1007/s00125-009-1625-zAuthors K. Steen Carlsson, Malmö University Hospital Department of Health Sciences Clinical Research Centre House 28 Floor 10 SE-205 02 Malmö SwedenM. Landin-Olsson, Lund University Hospital Department of Endocrinology Lund SwedenL. Nyström, Umeå University Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences Umeå SwedenH. J. Arnqvist, Linköping University Department of Clinical and Experimental Medicine Linköping SwedenJ. Bolinder, Karolinska Institutet Department of Medicine, Karolinska University Hospital... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3106012 Fri, 18 Dec 2009 07:04:30 +0100 3106012 http://www.medworm.com/index.php?rid=3106011&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc773621151677m24%2F Conclusions/interpretation  PKC activation augments glucagon secretion in mouse and human alpha cells. This effect involves translocation of PKCα and PKCδ to the plasma membrane, culminating in increased Ca2+-dependent exocytosis. In addition, we demonstrated that PKCα translocation and exocytosis exhibit differential Ca2+ channel dependence. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1635-xAuthors Y. Z. De Marinis, Lund University Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre CRC 91-11, UMAS entrance 72 SE-20502 Malmö SwedenE. Zhang, Lund University Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre CRC 91-11, UMAS entrance 72 SE-20502 Malmö SwedenS. Amiste... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3106011 Fri, 18 Dec 2009 07:04:30 +0100 3106011 http://www.medworm.com/index.php?rid=3098078&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmk502014714j6083%2F Conclusions/interpretation  Pregnant women with type 1 diabetes mellitus and tight metabolic control since before pregnancy displayed changes in insulin requirement and total insulin requirement with successive changes of direction. The sharpest slope was observed between 16 and 37 weeks, but insulin requirements were more unstable in the first 16 weeks. This information could help patients and physicians to react to changes in glycaemic pattern in a prompt and adequate way. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1633-zAuthors A. García-Patterson, Hospital de la Santa Creu i Sant Pau Department of Endocrinology and Nutrition Sant Antoni Mª Claret, 167 Barcelona 08025 SpainI. Gich, Hospital de la Santa Creu i Sant Pau Department ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3098078 Tue, 15 Dec 2009 06:44:21 +0100 3098078 http://www.medworm.com/index.php?rid=3086470&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F97r82064494t0t15%2F Conclusions/interpretation  This is the first demonstration that a loss of intestinal barrier integrity caused by an enteric bacterial pathogen results in the activation of diabetogenic CD8+ T cells and modulates insulitis. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1626-yAuthors A. S. Lee, University of British Columbia Department of Medicine Vancouver BC CanadaD. L. Gibson, British Columbia Children’s Hospital Department of Paediatrics, Division of Gastroenterology, University of British Columbia Room K4-188, 4480 Oak Street, Ambulatory Care Building Vancouver BC Canada V6H 3V4Y. Zhang, University of British Columbia Department of Medicine Vancouver BC CanadaH. P. Sham, British Columbia Children’s Hospital Department of Paediatrics, Divisio... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086470 Sun, 13 Dec 2009 06:46:57 +0100 3086470 http://www.medworm.com/index.php?rid=3086471&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1407811646912626%2F Conclusions/interpretation  Resistance exercise was better than aerobic or no exercise for improving physical health status in these patients. No exercise was superior to resistance or combined exercise for improving mental health status. Well-being was unchanged by intervention. Trial registration:  ClinicalTrials.gov NCT00195884 Funding:  This study was funded by the Canadian Institutes of Health Research (grant MCT-44155) and the Canadian Diabetes Association (The Lillian Hollefriend Grant). Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1631-1Authors R. D. Reid, University of Ottawa Heart Institute 40 Ruskin Street Ottawa ON Canada K1Y 4W7H. E. Tulloch, University of Ottawa Heart Institute 40 Ruskin Street Ottaw... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086471 Sun, 13 Dec 2009 06:46:56 +0100 3086471 http://www.medworm.com/index.php?rid=3086472&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp0xxp7q102tq7037%2F Conclusions/interpretation  These data demonstrate that ATPsyn-β is phosphorylated at multiple sites in human skeletal muscle, and suggest that abnormal site-specific phosphorylation of ATPsyn-β together with reduced content of OxPhos proteins contributes to mitochondrial dysfunction in insulin resistance. Further characterisation of phosphorylation of ATPsyn-β may offer novel targets of treatment in human diseases with mitochondrial dysfunction, such as diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1624-0Authors K. Højlund, Arizona State University Center for Metabolic Biology, School of Life Sciences P.O. Box 87370 Tempe AZ 85287 USAZ. Yi, Arizona State University Center for Metabolic Biology, School of Life Sciences P.O. Box 873... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086472 Sat, 12 Dec 2009 14:21:19 +0100 3086472 http://www.medworm.com/index.php?rid=3086474&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F23h815056m18n836%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1627-xAuthors T. L. Allen, Baker IDI Heart & Diabetes Institute Cellular and Molecular Metabolism Laboratory PO Box 6492 St Kilda Road Central Melbourne 3008 VIC AustraliaM. A. Febbraio, Baker IDI Heart & Diabetes Institute Cellular and Molecular Metabolism Laboratory PO Box 6492 St Kilda Road Central Melbourne 3008 VIC Australia Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086474 Thu, 10 Dec 2009 15:13:57 +0100 3086474 http://www.medworm.com/index.php?rid=3086473&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa683t721hw848072%2F Conclusion  Our results strongly suggest that progressive beta cell failure is the main determinant of progression of NGT to IGT. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1614-2Authors R. A. DeFronzo, University of Texas Health Science Center Diabetes Division 7703 Floyd Curl Drive San Antonio TX 78229 USAM. A. Banerji, SUNY Health Science Center at Brooklyn Brooklyn NY USAG. A. Bray, Pennington Biomedical Research Center and Louisiana State University Baton Rouge LA USAT. A. Buchanan, University of Southern California Keck School of Medicine Los Angeles CA USAS. Clement, Georgetown University Division of Endocrinology and Metabolism Washington DC USAR. R. Henry, VA San Diego Healthcare System and University of California at San Diego San Diego ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086473 Thu, 10 Dec 2009 15:13:57 +0100 3086473 http://www.medworm.com/index.php?rid=3086475&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh7876548u1142576%2F Conclusions/interpretation  Depression but not anxiety is associated with abdominal obesity and cardiovascular disease in people with type 2 diabetes mellitus. This knowledge may help to identify depressive symptoms among patients with type 2 diabetes who are at greatest risk. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1628-9Authors J. Labad, University of Edinburgh Endocrinology Unit, Centre for Cardiovascular Science, Queen’s Medical Research Institute 47 Little France Crescent Edinburgh EH16 4TJ UKJ. F. Price, University of Edinburgh Centre for Population Health Sciences Edinburgh UKM. W. J. Strachan, Metabolic Unit, Western General Hospital Edinburgh UKF. G. R. Fowkes, University of Edinburgh Centre for Population Health Scienc... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086475 Thu, 10 Dec 2009 15:13:56 +0100 3086475 http://www.medworm.com/index.php?rid=3086476&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq372tp307hm08760%2F This article presents the conclusions of a WHO Expert Consultation that evaluated the utility of the ‘metabolic syndrome’ concept in relation to four key areas: pathophysiology, epidemiology, clinical work and public health. The metabolic syndrome is a concept that focuses attention on complex multifactorial health problems. While it may be considered useful as an educational concept, it has limited practical utility as a diagnostic or management tool. Further efforts to redefine it are inappropriate in the light of current knowledge and understanding, and there is limited utility in epidemiological studies in which different definitions of the metabolic syndrome are compared. Metabolic syndrome is a pre-morbid condition rather than a clinical diagnosis, and should thus exclude i... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086476 Thu, 10 Dec 2009 15:13:55 +0100 3086476 http://www.medworm.com/index.php?rid=3086477&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq7u558t656r76807%2F Conclusions/interpretation  The case fatality rates for first ACS show similar improving trends in patients with type 2 diabetes and in those without. However, case fatality rates have remained higher in patients with type 2 diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1606-2Authors K. M. Winell, National Institute for Health and Welfare POB 30 00271 Helsinki FinlandR. Pääkkönen, National Institute for Health and Welfare POB 30 00271 Helsinki FinlandA. Pietilä, National Institute for Health and Welfare POB 30 00271 Helsinki FinlandM. K. Niemi, National Institute for Health and Welfare POB 30 00271 Helsinki FinlandA. R. Reunanen, National Institute for Health and Welfare POB 30 00271 Helsinki FinlandV. V. Salomaa, National Institute fo... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3086477 Thu, 10 Dec 2009 00:12:18 +0100 3086477 http://www.medworm.com/index.php?rid=3064572&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn356500438q15880%2F Conclusions/interpretation  This study provides evidence for AT2R playing a role in the development of diabetes-associated atherosclerosis. These findings suggest a potential utility of AT2R blockers in the prevention and treatment of diabetic macrovascular complications. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1619-xAuthors A. Koïtka, Baker IDI Heart and Diabetes Research Institute JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Diabetes Division PO Box 6492 St Kilda Road Central Melbourne VIC 8008 AustraliaZ. Cao, Baker IDI Heart and Diabetes Research Institute JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Diabetes Division PO Box 6492 St Kilda Road Central Melbourne VIC 8008 AustraliaP. Koh, Baker IDI ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3064572 Thu, 03 Dec 2009 13:04:00 +0100 3064572 http://www.medworm.com/index.php?rid=3064573&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftt07675511lk7400%2F Conclusions/interpretation  Potentiation of endogenous incretin action via DPP-4 inhibition or pharmacological augmentation of GLP-1R signalling reduces intestinal secretion of triacylglycerol, cholesterol and ApoB-48. Moreover, endogenous GLP-1R signalling is essential for the control of intestinal lipoprotein biosynthesis and secretion. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1611-5Authors J. Hsieh, University of Toronto Department of Biochemistry Toronto ON CanadaC. Longuet, University of Toronto Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital Toronto ON CanadaC. L. Baker, University of Toronto Molecular Structure and Function, Research Institute, The Hospital for Sick Children Toronto ON CanadaB. Qin, Bel... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3064573 Wed, 02 Dec 2009 18:49:43 +0100 3064573 http://www.medworm.com/index.php?rid=3064574&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0368581q0xm81747%2F Conclusions/interpretation  Among women with gestational diabetes mellitus, those at risk of future diabetes can be identified by HbA1c and fasting glucose values in the upper normal range during pregnancy. A family history of diabetes and previous pregnancies further increase this risk. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1621-3Authors M. Ekelund, Hospital of Helsingborg Department of Internal Medicine SE-251 87 Helsingborg SwedenN. Shaat, Lund University Department of Endocrinology, Malmö University Hospital Malmö SwedenP. Almgren, Lund University Department of Endocrinology, Malmö University Hospital Malmö SwedenL. Groop, Lund University Department of Endocrinology, Malmö University Hospital Malmö SwedenK. Berntorp, Lund Universit... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3064574 Tue, 01 Dec 2009 20:56:21 +0100 3064574 http://www.medworm.com/index.php?rid=3054160&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv31hgw77858tr168%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-009-1623-1Authors E. Ritz, University of Heidelberg Department of Nephrology Heidelberg GermanyG. C. Viberti, KCL Guy’s Hospital London UKL. M. Ruilope, Hospital 12 de Octubre Division of Hypertension Madrid SpainA. J. Rabelink, Leiden University Medical Center Department of Nephrology and Hypertension Leiden the NetherlandsJ. L. Izzo, Erie County Medical Center Department of Medicine Buffalo NY USAS. Katayama, Saitama Medical School The Fourth Department of Medicine Saitama Iruma JapanS. Ito, Tohoku University Graduate School of Medicine Department of Clinical Medicine, Division of Nephrology, Endocrinology and Vascular Medicine Sendai JapanA. Mimran, Hospital Lapeyronie Montpellier FranceJ. Menne, Hanover Medical School... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3054160 Tue, 01 Dec 2009 08:33:15 +0100 3054160 http://www.medworm.com/index.php?rid=3041298&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3tu206878l1214n8%2F Conclusions/interpretation  In our population of European ancestry, the ENPP1 SNP K121Q influenced the change in insulin sensitivity during lifestyle intervention. Thus, this SNP may determine susceptibility to environmental changes and could predict the success of lifestyle intervention. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1612-4Authors K. Müssig, University Hospital of Tübingen Department of Internal Medicine IV (Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry) Otfried-Müller-Str. 10 72076 Tübingen GermanyM. Heni, University Hospital of Tübingen Department of Internal Medicine IV (Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry) Otfried-Müller-Str. 10 72076 Tübingen GermanyC. Tha... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041298 Sun, 29 Nov 2009 09:38:10 +0100 3041298 http://www.medworm.com/index.php?rid=3041299&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj536555453t81381%2F Conclusions/interpretation  We found that admission glucose levels were associated with early mortality after ICH. In patients without diabetes, admission glucose levels were associated with long-term mortality. We therefore suggest that intensive lowering of glucose level should be further investigated in ICH patients. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1617-zAuthors S.-H. Lee, Seoul National University Hospital Department of Neurology 28 Yeongun-dong, Jongro-gu Seoul 110-744 Republic of KoreaB. J. Kim, Seoul National University Hospital Department of Neurology 28 Yeongun-dong, Jongro-gu Seoul 110-744 Republic of KoreaH.-J. Bae, Seoul National University Bundang Hospital Department of Neurology Seongnam-si Kyunggi-do Republic of KoreaJ.... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041299 Sun, 29 Nov 2009 09:38:08 +0100 3041299 http://www.medworm.com/index.php?rid=3041300&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq052255t4574425w%2F Conclusions/interpretation  IA-2A+ and/or ZnT8A+ first-degree relatives may be the participants of choice in future secondary prevention trials with immunointervention in relatives of type 1 diabetic patients. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1618-yAuthors J. De Grijse, Brussels Free University–VUB Diabetes Research Center Laarbeeklaan 103 B-1090 Brussels BelgiumM. Asanghanwa, Brussels Free University–VUB Diabetes Research Center Laarbeeklaan 103 B-1090 Brussels BelgiumB. Nouthe, Brussels Free University–VUB Diabetes Research Center Laarbeeklaan 103 B-1090 Brussels BelgiumN. Albrecher, University Hospital Brussels Free University–UZ Brussel Department of Clinical Chemistry and Radioimmunology Brussels BelgiumP. Goubert, Brussels... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041300 Sun, 29 Nov 2009 09:38:06 +0100 3041300 http://www.medworm.com/index.php?rid=3041301&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk86h64j04h1j0088%2F Conclusions/interpretation  This baboon model of wound healing reflects the abnormal microenvironment seen in human diabetic wounds and provides insights into the dysregulation of CTGF in diabetic wounds. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1610-6Authors S. E. Thomson, University of Sydney Discipline of Medicine Camperdown Sydney NSW AustraliaS. V. McLennan, University of Sydney Discipline of Medicine Camperdown Sydney NSW AustraliaA. Hennessy, Royal Prince Alfred Hospital Department of Renal Medicine Camperdown Sydney NSW AustraliaP. Boughton, St George Hospital St George Clinical School Kogarah NSW AustraliaJ. Bonner, Royal Prince Alfred Hospital Department of Endocrinology Camperdown Sydney NSW AustraliaH. Zoellner, University of Sydney... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041301 Sun, 29 Nov 2009 09:31:25 +0100 3041301 http://www.medworm.com/index.php?rid=3041302&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv18v5184kt526567%2F Conclusions/interpretation  Targeted elimination of cells expressing the IL-2 receptor by this fusion protein disrupts the autoimmune pathogenesis in prediabetic and diabetic NOD mice, despite depletion of CD25+ regulatory T cells. Furthermore, this particular fusion protein is permissive to the development of FOXP3+ T cells that might contribute to protracted protection from the progression of insulitis and overt hyperglycaemia. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1604-4Authors S. Yarkoni, GASR Biotechnology Kfar-Saba 44395 IsraelA. Kaminitz, Schneider Children’s Medical Center of Israel Frankel Laboratory, Center for Stem Cell Research 14 Kaplan Street Petach Tikva Israel 49202Y. Sagiv, GASR Biotechnology Kfar-Saba 44395 IsraelN. Asken... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041302 Sat, 28 Nov 2009 07:02:25 +0100 3041302 http://www.medworm.com/index.php?rid=3041303&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkj73627vu4g31135%2F Conclusions/interpretation  Nocturnal intermittent hypoxia was associated with increased risk of developing type 2 diabetes among middle-aged Japanese. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1616-0Authors I. Muraki, Osaka University Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 JapanT. Tanigawa, Ehime University Department of Public Health, Doctoral Program in Social Medicine, Graduate School of Medicine Toon JapanK. Yamagishi, University of Tsukuba Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and Institute of Community Medicine Tsukuba JapanS. Sakurai, Ehime University Department of Public Health, Doctoral Program in Soci... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041303 Sat, 28 Nov 2009 07:02:22 +0100 3041303 http://www.medworm.com/index.php?rid=3041304&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv784q62433045g41%2F Conclusions/interpretation  These results provide a novel mechanism whereby peroxisome proliferator-activated receptor-γ activation can terminate WNT signalling and promote adipogenesis. Furthermore, they provide an explanation for why TZD treatment can lead to reduced bone formation and increased risk of fractures, since inhibited WNT signalling in progenitor cells promotes adipogenesis while osteogenesis is reduced. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1615-1Authors B. Gustafson, Sahlgrenska University Hospital The Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine Blå Stråket 3 413 45 Gothenburg SwedenB. Eliasson, Sahlgrenska Univer... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041304 Fri, 27 Nov 2009 07:10:13 +0100 3041304 http://www.medworm.com/index.php?rid=3041305&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl0nu681260p164h6%2F Conclusions/interpretation  We have independently replicated the association between rs10494366 in NOS1AP and incident diabetes among white CCB users. Further exploration of NOS1AP variants and type 2 diabetes and functional studies of NOS1AP in type 2 diabetes pathology is warranted. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1608-0Authors A. Y. Chu, Johns Hopkins School of Public Health Department of Epidemiology Baltimore MD USAJ. Coresh, Johns Hopkins School of Public Health Department of Epidemiology Baltimore MD USAD. E. Arking, Johns Hopkins University School of Medicine Nathan McKusick Institute of Genomic Medicine Baltimore MD USAJ. S. Pankow, University of Minnesota School of Public Health Department of Epidemiology and Community Health ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041305 Fri, 27 Nov 2009 07:10:12 +0100 3041305 http://www.medworm.com/index.php?rid=3041306&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F435ux720p60x584v%2F Conclusions/interpretation  Long-term exposure of type 2 diabetic patients to thiazolidinediones was associated with higher odds of fractures among women without a significant increase in odds of fractures among men. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1609-zAuthors F.-Y. Hsiao, University of Maryland School of Pharmacy Pharmaceutical Health Services Research Department 220 Arch Street, 12th Floor Baltimore MD 21201 USAC. D. Mullins, University of Maryland School of Pharmacy Pharmaceutical Health Services Research Department 220 Arch Street, 12th Floor Baltimore MD 21201 USA Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041306 Fri, 27 Nov 2009 07:10:11 +0100 3041306 http://www.medworm.com/index.php?rid=3041307&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx2724w46620878mx%2F Conclusions/interpretation  Fasting glucose association at four tested loci was proven to be replicable across ethnic groups. Despite this overall consistency, ethnic diversity in the pattern and strength of linkage disequilibrium certainly exists and can help to appreciably reduce potential causal variants after GWA studies. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1595-1Authors F. Takeuchi, International Medical Center of Japan Department of Gene Diagnostics and Therapeutics, Research Institute 1-21-1 Toyama, Shinjuku-ku Tokyo 162-8655 JapanT. Katsuya, Osaka University Graduate School of Medicine Department of Clinical Gene Therapy Suita JapanS. Chakrewarthy, University of Kelaniya Faculty of Medicine Kelaniya Sri LankaK. Yamamoto, Kyushu Un... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3041307 Wed, 25 Nov 2009 16:48:27 +0100 3041307 http://www.medworm.com/index.php?rid=3031972&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp40m5705n0118370%2F Conclusions/interpretation  Hypoadiponectinaemia during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia, and hence may be relevant to the pathophysiology relating GDM with type 2 diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1600-8Authors R. Retnakaran, Mount Sinai Hospital Leadership Sinai Centre for Diabetes 60 Murray Street, Suite-L5-039 Mailbox-21 Toronto ON Canada M5T3L9Y. Qi, Mount Sinai Hospital Leadership Sinai Centre for Diabetes 60 Murray Street, Suite-L5-039 Mailbox-21 Toronto ON Canada M5T3L9P. W. Connelly, University of Toronto Division of Endocrinology Toronto ON CanadaM. Sermer, Mount Sinai Hospital Division of Obstetrics and Gynecology Toronto ON CanadaA. J. Hanley, Mount Sinai ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3031972 Tue, 24 Nov 2009 07:16:49 +0100 3031972 http://www.medworm.com/index.php?rid=3031971&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy18706l50m379402%2F Conclusions/interpretation  Our data suggest that NOS1AP variants may not play a dominant role in susceptibility to type 2 diabetes, but a minor effect cannot be excluded. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1594-2Authors C. Hu, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Department of Endocrinology and Metabolism 600 Yishan Road Shanghai 200233 People’s Republic of ChinaC. Wang, Shanghai Diabetes Institute Shanghai People’s Republic of ChinaR. Zhang, Shanghai Diabetes Institute Shanghai People’s Republic of ChinaM. C. Ng, The Chinese University of Hong Kong Department of Medicine and Therapeutics, Prince of Wales Hospital Shatin Hong Kong SAR People’s Republic of ChinaY. Bao, Shanghai Jiao Tong University Aff... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3031971 Tue, 24 Nov 2009 07:16:49 +0100 3031971 http://www.medworm.com/index.php?rid=3031973&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F726272r852527471%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1613-3Authors C. M. Schooling, The University of Hong Kong School of Public Health, Li Ka Shing Faculty of Medicine 21 Sassoon Road Pokfulam Hong Kong SAR People’s Republic of ChinaC. Q. Jiang, Guangzhou Number 12 Hospital Guangzhou Occupational Diseases Prevention and Treatment Centre Guangzhou People’s Republic of ChinaW. S. Zhang, Guangzhou Number 12 Hospital Guangzhou Occupational Diseases Prevention and Treatment Centre Guangzhou People’s Republic of ChinaT. H. Lam, The University of Hong Kong School of Public Health, Li Ka Shing Faculty of Medicine 21 Sassoon Road Pokfulam Hong Kong SAR People’s Republic of ChinaK. K. Cheng, The University of Birmingham Department of Public Health and Epidemiology Birmingha... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3031973 Tue, 24 Nov 2009 07:16:47 +0100 3031973 http://www.medworm.com/index.php?rid=3031974&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn41016hpgt721g59%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1605-3Authors H. Hauner, Technical University of Munich Else Kröner Fresenius Centre for Nutritional Medicine Gregor-Mendel-Strasse 2 85350 Freising-Weihenstephan Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3031974 Tue, 24 Nov 2009 07:16:46 +0100 3031974 http://www.medworm.com/index.php?rid=3031975&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F088058278l4120w1%2F Conclusions/interpretation  NOD peritoneal B cells are hyperactivated, migrate to the pancreatic lymph nodes and are capable of driving insulin-specific CD4 T cell activation. These characteristics could make them important for inducing or amplifying T cell responses against islet-antigens. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1599-xAuthors C. Alam, University of Turku Department of Medical Microbiology and Immunology Kiinamyllynkatu 13 20520 Turku FinlandS. Valkonen, University of Turku Department of Medical Microbiology and Immunology Kiinamyllynkatu 13 20520 Turku FinlandS. Ohls, University of Turku Department of Medical Microbiology and Immunology Kiinamyllynkatu 13 20520 Turku FinlandK. Törnqvist, Åbo Akademi University Department o... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3031975 Mon, 23 Nov 2009 17:12:55 +0100 3031975 http://www.medworm.com/index.php?rid=3020332&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh02pp0843jk366jt%2F Conclusions/interpretation  Impaired GLP-1 secretion is associated with IGT, but not with type 2 diabetes mellitus. This finding in the latter group might be confounded by oral glucose-lowering treatment. GLP-1 does not predict CHD. Although ΔGLP-1 was associated with insulin sensitivity in the type 2 diabetes mellitus group, GLP-1 does not seem to be a predictor of CHD in insulin-resistant patients. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1596-0Authors D. Nathanson, Karolinska Institutet Department of Internal Medicine Södersjukhuset AB SE-118 83 Stockholm SwedenB. Zethelius, Uppsala University Department of Public Health and Caring Sciences/Geriatrics Uppsala SwedenC. Berne, Uppsala University Hospital Department of Medical Sc... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3020332 Sat, 21 Nov 2009 09:05:20 +0100 3020332 http://www.medworm.com/index.php?rid=3020333&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq10646p5620521qk%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-009-1607-1Authors J. Olerud, Uppsala University Biomedical Center Department of Medical Cell Biology Uppsala SwedenN. Kanaykina, Biomedical Center Department of Neuroscience PO Box 593 751 24 Uppsala SwedenS. Vasylovska, Biomedical Center Department of Neuroscience PO Box 593 751 24 Uppsala SwedenD. King, Biomedical Center Department of Neuroscience PO Box 593 751 24 Uppsala SwedenM. Sandberg, Uppsala University Biomedical Center Department of Medical Cell Biology Uppsala SwedenL. Jansson, Uppsala University Biomedical Center Department of Medical Cell Biology Uppsala SwedenE. N. Kozlova, Biomedical Center Department of Neuroscience PO Box 593 751 24 Uppsala Sweden Journal DiabetologiaOnline ISSN 1432-0428Print I... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3020333 Sat, 21 Nov 2009 09:05:16 +0100 3020333 http://www.medworm.com/index.php?rid=3016262&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh553h35phg074747%2F Conclusions/interpretation  In individuals with a BMI of <27 kg/m2, GGT was the strongest predictor of diabetes after fasting hyperglycaemia. This association with incident diabetes remained after adjustment for conventional markers of insulin resistance, suggesting potential interactions between GGT, enhanced hepatic neoglucogenesis and/or early alterations of insulin secretion. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1602-6Authors A. Gautier, CHU Rennes, Hôpital Sud Service Endocrinologie 16 Boulevard de Bulgarie 35203 Rennes FranceB. Balkau, INSERM U780-IFR69 Villejuif FranceC. Lange, INSERM U780-IFR69 Villejuif FranceJ. Tichet, IRSA La Riche FranceF. Bonnet, CHU Rennes, Hôpital Sud Service Endocrinologie 16 Boulevard de Bulgarie... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3016262 Thu, 19 Nov 2009 19:59:44 +0100 3016262 http://www.medworm.com/index.php?rid=3098079&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9407w071660h7561%2F Conclusions/interpretation  Although previously associated with inpatient morbidity and mortality, admission dysglycaemia was not associated with an increased risk of death or CAP readmission at 90 days or 1 year among those who survived hospitalisation for pneumonia. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1598-yAuthors D. T. Eurich, University of Alberta Department of Public Health Sciences, School of Public Health 13-103 Clinical Sciences Bldg Edmonton T6G 2G3 AB CanadaJ. M. Gamble, University of Alberta Department of Public Health Sciences, School of Public Health 13-103 Clinical Sciences Bldg Edmonton T6G 2G3 AB CanadaT. J. Marrie, University of Alberta Department of Medicine, Faculty of Medicine and Dentistry Edmonton AB Canada... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3098079 Thu, 19 Nov 2009 19:59:43 +0100 3098079 http://www.medworm.com/index.php?rid=3016263&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9407w071660h7561%2F Conclusions/interpretation  Although previously associated with inpatient morbidity and mortality, admission dysglycaemia was not associated with an increased risk of death or CAP readmission at 90 days or 1 year among those who survived hospitalisation for pneumonia. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1598-yAuthors D. T. Eurich, University of Alberta Department of Public Health Sciences, School of Public Health 13-103 Clinical Sciences Bldg Edmonton T6G 2G3 AB CanadaJ. M. Gamble, University of Alberta Department of Public Health Sciences, School of Public Health 13-103 Clinical Sciences Bldg Edmonton T6G 2G3 AB CanadaT. J. Marrie, University of Alberta Department of Medicine, Faculty of Medicine and Dentistry Edmonton AB Canada... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3016263 Thu, 19 Nov 2009 19:59:43 +0100 3016263 http://www.medworm.com/index.php?rid=3009990&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2q5137222n432764%2F Conclusions/interpretation  Elevated sTNFR-2 levels may be an important and potentially modifiable risk factor for eGFR decline in type 2 diabetes, especially in those with a BMI of ≥30 kg/m2. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1597-zAuthors J. Lin, MRB-4, Brigham and Women’s Hospital Renal Division 75 Francis Street Boston MA 02115 USAF. B. Hu, Harvard Medical School Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital Boston MA USAC. Mantzoros, Beth Israel Deaconess Medical Center Division of Endocrinology, Department of Medicine Boston MA USAG. C. Curhan, MRB-4, Brigham and Women’s Hospital Renal Division 75 Francis Street Boston MA 02115 USA Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3009990 Wed, 18 Nov 2009 09:30:25 +0100 3009990 http://www.medworm.com/index.php?rid=3009992&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5503740624837x2%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1603-5Authors M. Nauck, Diabeteszentrum Bad Lauterberg Kirchberg 21 37431 Bad Lauterberg im Harz Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3009992 Wed, 18 Nov 2009 00:03:09 +0100 3009992 http://www.medworm.com/index.php?rid=3009991&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7426m70wnj375770%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1601-7Authors A. Esteghamati, Tehran University of Medical Sciences Endocrinology and Metabolism Research Centre (EMRC), Vali-Asr Hospital, School of Medicine Tehran IranO. Khalilzadeh, Tehran University of Medical Sciences Endocrinology and Metabolism Research Centre (EMRC), Vali-Asr Hospital, School of Medicine Tehran IranM. Abbasi, Tehran University of Medical Sciences Endocrinology and Metabolism Research Centre (EMRC), Vali-Asr Hospital, School of Medicine Tehran Iran Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=3009991 Wed, 18 Nov 2009 00:03:09 +0100 3009991 http://www.medworm.com/index.php?rid=3009993&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F67vr40563676l346%2F Conclusions/interpretation  Specific training can improve gait speed, balance, muscle strength and joint mobility in diabetic patients. Further studies are needed to explore the influence of these improvements on the number of reported falls, patients’ physical activity levels and quality of life. Trial registration:  ClinicalTrials.gov NCT00637546 Funding:  This work was supported by the Swiss National Foundation (SNF): PBSKP-123446/1/ Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1592-4Authors L. Allet, Maastricht University and Caphri Research School Department of Epidemiology Maastricht the NetherlandsS. Armand, Geneva University Hospital and University of Geneva Willy Taillard Laboratory of Kinesiology Genev... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3009993 Wed, 18 Nov 2009 00:03:07 +0100 3009993 http://www.medworm.com/index.php?rid=3009994&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw52365416n5113gx%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-009-1583-5Authors S. Beck Jørgensen, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaH. M. O’Neill, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaK. Hewitt, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaB. E. Kemp, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC AustraliaG. R. Steinberg, University of Melbourne St Vincent’s Institute of Medical Research and Department of Medicine Fitzroy VIC Australia Journal DiabetologiaOnline ISSN 1432-0428Prin... Diabetologia journals http://www.medworm.com/rss/comments.php?id=3009994 Wed, 18 Nov 2009 00:03:06 +0100 3009994 http://www.medworm.com/index.php?rid=2990564&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0w2tn1124330rx42%2F Conclusions/interpretation  The histological features of insulitis in transplanted pancreas were consistent with common type 1 diabetes mellitus, but the clinical course of the recurrence appeared to be more rapid. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1593-3Authors M. Ishida-Oku, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582 JapanM. Iwase, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582 JapanA. Sugitani, Fujita Health University Department of Organ Transplantation and Regenerative Medicine Toyoake JapanK. Masutani, Kyushu University Departm... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2990564 Thu, 12 Nov 2009 18:33:04 +0100 2990564 http://www.medworm.com/index.php?rid=2986613&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmq1x116143426343%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1565-7Authors The CONTROL Group, University of Sydney The George Institute for International Health PO Box M201 Missenden Rd Sydney NSW 2050 Australia Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2986613 Wed, 11 Nov 2009 19:19:12 +0100 2986613 http://www.medworm.com/index.php?rid=2986614&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5615143381155345%2F Conclusions/interpretation  We developed and validated a clinical prediction rule that uses relatively easily obtainable patient characteristics to predict microalbuminuria in patients with type 1 diabetes. This rule can help clinicians to decide on more frequent check-ups for patients at high risk of microalbuminuria in order to prevent long-term chronic complications. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1585-3Authors Y. Vergouwe, University Medical Centre Utrecht Julius Center for Health Sciences and Primary Care Str 6.131 P.O. Box 85500 3508 GA Utrecht the NetherlandsS. S. Soedamah-Muthu, University Medical Centre Utrecht Julius Center for Health Sciences and Primary Care Str 6.131 P.O. Box 85500 3508 GA Utrecht the NetherlandsJ. Zgi... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2986614 Wed, 11 Nov 2009 19:19:11 +0100 2986614 http://www.medworm.com/index.php?rid=2986615&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6335w2j1u74p3l3%2F Conclusions/interpretation  PPARα protected INS-1E beta cells from oleate-induced dysfunction, promoting both preservation of glucose metabolic pathways and fatty acid turnover. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1590-6Authors F. Frigerio, University of Geneva Medical Center Department of Cell Physiology and Metabolism 1 rue Michel-Servet 1211 Geneva 4 SwitzerlandT. Brun, University of Geneva Medical Center Department of Cell Physiology and Metabolism 1 rue Michel-Servet 1211 Geneva 4 SwitzerlandC. Bartley, University of Geneva Medical Center Department of Cell Physiology and Metabolism 1 rue Michel-Servet 1211 Geneva 4 SwitzerlandA. Usardi, University of Geneva Medical Center Department of Cell Physiology and Metabolism 1 rue Michel-Ser... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2986615 Wed, 11 Nov 2009 19:19:09 +0100 2986615 http://www.medworm.com/index.php?rid=2982713&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy3r4l380hv270526%2F Conclusions/interpretation  We demonstrated that LCM of pancreatic islet cells in combination with transcriptional profiling can be successfully used to identify novel candidate genes for diabetes. Our data strongly implicate glucose-induced oxidative stress in disease progression. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1576-4Authors T. Dreja, German Institute of Human Nutrition Potsdam-Rehbruecke Department of Pharmacology Arthur-Scheunert-Allee 114–116 14558 Nuthetal GermanyZ. Jovanovic, University of Cambridge Metabolic Research Laboratories Institute of Metabolic Science, Level 4 Box 289 Addenbrooke’s Hospital Cambridge CB2 0QQ UKA. Rasche, Max Planck Institute for Molecular Genetics Department of Vertebrate Genomics Berlin GermanyR.... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2982713 Tue, 10 Nov 2009 07:54:19 +0100 2982713 http://www.medworm.com/index.php?rid=2982714&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4361x1704230575%2F Conclusions/interpretation  Several candidate loci were identified that are nominally associated with SI and/or DI in Hispanic-American participants. Replication of these findings in independent cohorts and additional focused analysis of these loci is warranted. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1586-2Authors N. D. Palmer, Wake Forest University School of Medicine Department of Biochemistry, Centers for Human Genomics & Diabetes Research 1 Medical Center Blvd Winston-Salem NC 27157 USAC. D. Langefeld, Wake Forest University School of Medicine Department of Public Health Sciences Winston-Salem NC USAJ. T. Ziegler, Wake Forest University School of Medicine Department of Public Health Sciences Winston-Salem NC USAF. Hsu, Wake Forest Univers... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2982714 Tue, 10 Nov 2009 07:54:14 +0100 2982714 http://www.medworm.com/index.php?rid=2982715&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffl1x8071q6l73j16%2F Conclusions/interpretation  Human IL6 enhanced central leptin action in mice, promoting nutrient homeostasis and preventing diet-induced obesity. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1580-8Authors M. Sadagurski, Harvard Medical School, Karp Family Research Laboratories Howard Hughes Medical Institute, Division of Endocrinology, Children’s Hospital Boston Rm 4210, 300 Longwood Avenue Boston MA 02115 USAL. Norquay, Harvard Medical School, Karp Family Research Laboratories Howard Hughes Medical Institute, Division of Endocrinology, Children’s Hospital Boston Rm 4210, 300 Longwood Avenue Boston MA 02115 USAJ. Farhang, Harvard Medical School, Karp Family Research Laboratories Howard Hughes Medical Institute, Division of Endocrinology, Childre... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2982715 Tue, 10 Nov 2009 07:54:13 +0100 2982715 http://www.medworm.com/index.php?rid=2982716&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg972h63q8666x50g%2F Conclusions/interpretation  These studies indicate that TNF-α dysregulation in diabetic wounds impairs healing, which may involve enhanced fibroblast apoptosis and decreased proliferation. In vitro, TNF-α induced gene sets through FOXO1 that regulate a number of pathways that could influence inflammation and apoptosis. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1529-yAuthors M. F. Siqueira, Boston University School of Dental Medicine Department of Periodontology and Oral Biology Boston MA USAJ. Li, University of Medicine and Dentistry of New Jersey Department of Periodontics 110 Bergen Street C-781 Newark NJ 07101 USAL. Chehab, Boston University School of Dental Medicine Department of Periodontology and Oral Biology Boston MA USAT. Desta, Unive... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2982716 Mon, 09 Nov 2009 19:11:23 +0100 2982716 http://www.medworm.com/index.php?rid=2975094&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh66516g9r221mrmw%2F Conclusions/interpretation  Canonical WNT signalling is not active in adult beta cells in vivo. WNT4 provides a potential mechanism for suppression of canonical WNT signalling in obese mice. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1578-2Authors J. Krützfeldt, The Rockefeller University Laboratory of Metabolic Diseases New York NY USAM. Stoffel, The Rockefeller University Laboratory of Metabolic Diseases New York NY USA Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2975094 Sun, 08 Nov 2009 08:03:54 +0100 2975094 http://www.medworm.com/index.php?rid=2975095&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F17r1g7t406267066%2F Conclusions/interpretation  In non-diabetic participants given exenatide, blood glucose concentrations rise rather than fall during aerobic exercise with an associated greater catecholamine response. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-009-1579-1Authors E. Y. H. Khoo, Nottingham University Hospitals Department of Diabetes and Endocrinology Queens Medical Centre Campus, Derby Road Nottingham NG7 2UH UKJ. Wallis, University of Nottingham School of Biomedical Sciences Nottingham UKK. Tsintzas, University of Nottingham School of Biomedical Sciences Nottingham UKI. A. Macdonald, University of Nottingham School of Biomedical Sciences Nottingham UKP. Mansell, Nottingham University Hospitals Department of Diabetes and Endocrinology Queens ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2975095 Sat, 07 Nov 2009 07:48:48 +0100 2975095 http://www.medworm.com/index.php?rid=2971507&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg8316562t238g721%2F Conclusions/interpretation  Physical activity was associated with a lower progression to diabetes in the total study population and in individuals with i-IGT, a condition primarily characterised by muscle insulin resistance. Physical activity did not predict progression to diabetes in individuals with i-IFG, a condition primarily characterised by hepatic insulin resistance. Our results suggest that there is a differential relationship between physical activity and progression to diabetes among those with i-IFG and i-IGT. Therefore, clinical trials testing the effect of physical activity on progression from i-IFG to diabetes are needed. Trial registration:  ClinicalTrials.gov ID No.: NCT00289237 Funding:  The Danish Medical Research Council, t... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2971507 Fri, 06 Nov 2009 19:09:55 +0100 2971507 http://www.medworm.com/index.php?rid=2971506&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqjp73q871g772480%2F Conclusions/interpretation  Clamp-derived functional variables stratify risk of diabetes in IA-2A+ FDRs and may more consistently identify progressors than OGTT-derived variables. A low first-phase C-peptide response specifically predicts impending diabetes while a low second-phase response may reflect an earlier disease stage. Trial registration:  ClinicalTrials.gov NCT00654121 Funding:  The insulin trial was financially supported by Novo Nordisk Pharma nv. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1569-3Authors E. Vandemeulebroucke, Brussels Free University-VUB Diabetes Research Center Laarbeeklaan 103 1090 Brussels BelgiumB. Keymeulen, Brussels Free University-VUB Diabetes Research Center Laarbeeklaan 103 109... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2971506 Fri, 06 Nov 2009 19:09:55 +0100 2971506 http://www.medworm.com/index.php?rid=2971508&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxx03308577828v33%2F Conclusions/interpretation  In this cohort, HOMA-%S showed no association with all-cause mortality and only a modest association with CVD events, largely explained by its association with HDL. Fasting plasma glucose was a better predictor of CVD than HOMA-%S. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1588-0Authors E. L. M. Barr, Baker IDI Heart and Diabetes Institute Department of Epidemiology and Clinical Diabetes 250 Kooyong Road Caulfield 3162 VIC AustraliaA. J. Cameron, Baker IDI Heart and Diabetes Institute Department of Epidemiology and Clinical Diabetes 250 Kooyong Road Caulfield 3162 VIC AustraliaB. Balkau, Baker IDI Heart and Diabetes Institute Department of Epidemiology and Clinical Diabetes 250 Kooyong Road Caulfield 3162 VIC Australi... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2971508 Fri, 06 Nov 2009 08:48:03 +0100 2971508 http://www.medworm.com/index.php?rid=2971509&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1t24162512x26813%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1591-5Authors P. C. Butler, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USAA. V. Matveyenko, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USAS. Dry, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USAA. Bhushan, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USAR. Elashoff, UCLA Larry Hillblom Islet Research Center at David Geffen School of Medicine 900 Weyburn Place #A Los Angeles CA 90024-2852 USA Jour... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2971509 Thu, 05 Nov 2009 19:04:23 +0100 2971509 http://www.medworm.com/index.php?rid=2971510&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgp766402rv461t5w%2F Conclusions/interpretation  Our work provides the first evidence that direct renin inhibition with aliskiren protects against cardiovascular complications and pancreatic injury, through the attenuation of oxidative stress. Thus, we propose that aliskiren may be a promising therapeutic agent for type 2 diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1575-5Authors Y. F. Dong, Kumamoto University Graduate School of Medical Sciences Department of Pharmacology and Molecular Therapeutics 1-1-1 Honjyo Kumamoto 860-8556 JapanL. Liu, Kumamoto University Graduate School of Medical Sciences Department of Pharmacology and Molecular Therapeutics 1-1-1 Honjyo Kumamoto 860-8556 JapanK. Kataoka, Kumamoto University Graduate School of Medical Sciences Depar... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2971510 Thu, 05 Nov 2009 19:04:22 +0100 2971510 http://www.medworm.com/index.php?rid=2968783&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm001524034803822%2F Abstract  The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are co... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2968783 Wed, 04 Nov 2009 19:46:30 +0100 2968783 http://www.medworm.com/index.php?rid=2968784&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd4kl442t00622362%2F Conclusions/interpretation  In type 1 and type 2 diabetes, insulin exerts an inhibitory effect on oxidative stress, a metabolic disorder that is significantly activated by sustained hyperglycaemia and glucose variability in non-insulin-treated type 2 diabetes. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1574-6Authors L. Monnier, University Institute of Clinical Research Laboratory of Human Nutrition and Atherogenesis 34093 Montpellier Cedex 5 FranceC. Colette, University Institute of Clinical Research Laboratory of Human Nutrition and Atherogenesis 34093 Montpellier Cedex 5 FranceE. Mas, University Institute of Clinical Research Laboratory of Human Nutrition and Atherogenesis 34093 Montpellier Cedex 5 FranceF. Michel, University Institute of Clini... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2968784 Wed, 04 Nov 2009 19:46:23 +0100 2968784 http://www.medworm.com/index.php?rid=2960908&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv375012800n22x47%2F Content Type Journal ArticleCategory List of RefereesDOI 10.1007/s00125-009-1584-4 Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2960908 Tue, 03 Nov 2009 11:08:11 +0100 2960908 http://www.medworm.com/index.php?rid=2952127&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj68535u4067557h5%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s00125-009-1589-zAuthors C. Menzaghi, IRCCS ‘Casa Sollievo della Sofferenza’, Viale Padre Pio Research Unit of Diabetes and Endocrine Diseases 71013 San Giovanni Rotondo (FG) ItalyV. Trischitta, IRCCS ‘Casa Sollievo della Sofferenza’, Viale Padre Pio Research Unit of Diabetes and Endocrine Diseases 71013 San Giovanni Rotondo (FG) Italy Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2952127 Sat, 31 Oct 2009 12:57:31 +0100 2952127 http://www.medworm.com/index.php?rid=2952128&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr2p15l47538642k5%2F Conclusions/interpretation  In non-demented patients with type 2 diabetes, cognitive decrements are moderate in size and cognitive decline over 4 years is largely within the range of what can be viewed in normal ageing. Apparently, diabetes-related cognitive changes develop slowly over a prolonged period of time. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1571-9Authors E. van den Berg, University Medical Center Utrecht Department of Neurology (G03.228), Rudolf Magnus Institute of Neuroscience P.O. Box 85500 3508 GA Utrecht the NetherlandsY. D. Reijmer, University Medical Center Utrecht Department of Neurology (G03.228), Rudolf Magnus Institute of Neuroscience P.O. Box 85500 3508 GA Utrecht the NetherlandsJ. de Bresser, University Medical ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2952128 Sat, 31 Oct 2009 12:57:30 +0100 2952128 http://www.medworm.com/index.php?rid=2952129&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh184342738kj47tv%2F Conclusions/interpretation  The timing of OVOL1 appearance in pancreas and its increased levels in differentiated cells suggest that OVOL1 promotes the transition of cells from a proliferating, less-differentiated state to a quiescent more-differentiated state. We conclude that OVOL1, a downstream target of NGN3, may play an important role in regulating the balance between proliferation and differentiation of pancreatic cells. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1567-5Authors A. Vetere, Harvard Medical School Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, 1 Joslin Place Boston MA 02215 USAW.-C. Li, Harvard Medical School Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, 1 Joslin Place ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2952129 Sat, 31 Oct 2009 12:57:29 +0100 2952129 http://www.medworm.com/index.php?rid=2947929&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd598g275801q00tj%2F Conclusions/interpretation  Although observational correlations do not prove causality, in normoalbuminuric type 2 diabetic patients the albumin excretion rate is correlated with many factors that are potentially susceptible to intervention. Trial registration:  ClinicalTrials.gov ID no.: NCT00185159 Funding:  This study was sponsored by Daichii-Sankyo. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1577-3Authors E. Ritz, University of Heidelberg Department of Nephrology Heidelberg GermanyG. C. Viberti, KCL Guy’s Hospital London UKL. M. Ruilope, Hospital 12 de Octubre Division of Hypertension Madrid SpainA. J. Rabelink, Leiden University Medical Center Department of Nephrology and Hypertension Leiden the Netherland... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2947929 Fri, 30 Oct 2009 08:03:37 +0100 2947929 http://www.medworm.com/index.php?rid=2947930&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F78308675g6352128%2F Conclusions/interpretation  A short test can achieve a good approximation of minimal model analysis and clamp insulin sensitivity. The importance of a method such as CSI is that it allows analysis of IVGTT datasets with samples limited to 1 h. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1547-9Authors A. Tura, Metabolic Unit, ISIB-CNR Corso Stati Uniti, 4 35127 Padova ItalyS. Sbrignadello, Metabolic Unit, ISIB-CNR Corso Stati Uniti, 4 35127 Padova ItalyE. Succurro, University Magna Græcia of Catanzaro Department of Experimental and Clinical Medicine Catanzaro ItalyL. Groop, Lund University Lund University Diabetes Centre Malmö SwedenG. Sesti, University Magna Græcia of Catanzaro Department of Experimental and Clinical Medicine Catanzaro Ita... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2947930 Thu, 29 Oct 2009 19:41:44 +0100 2947930 http://www.medworm.com/index.php?rid=2945258&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fal938221g2gq1772%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00125-009-1566-6Authors S. K. Pinnamaneni, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC AustraliaR. J. Southgate, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC AustraliaM. A. Febbraio, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC AustraliaM. J. Watt, RMIT University Cellular and Molecular Metabolism Laboratory, School of Medical Sciences Melbourne VIC Australia Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2945258 Thu, 29 Oct 2009 07:00:55 +0100 2945258 http://www.medworm.com/index.php?rid=2941097&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd25964805hrk1414%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1581-7Authors A. K. Khuwaja, Aga Khan University Department of Family Medicine Karachi 74880 PakistanL. A. Khowaja, Aga Khan University Department of Community Health Sciences Karachi PakistanP. Cosgrove, The Open University in the North West Faculty of Social Sciences Sharston Manchester UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2941097 Wed, 28 Oct 2009 07:08:43 +0100 2941097 http://www.medworm.com/index.php?rid=2936415&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft381754525m88188%2F Conclusions/interpretation  This study demonstrates that ETA blockade with avosentan may provide an alternate therapeutic strategy for the treatment of diabetic micro- and macrovascular complications. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1540-3Authors A. M. D. Watson, Baker IDI Heart and Diabetes Institute PO Box 6492 St Kilda Road Central Melbourne 8008 VIC AustraliaJ. Li, Baker IDI Heart and Diabetes Institute PO Box 6492 St Kilda Road Central Melbourne 8008 VIC AustraliaC. Schumacher, Novartis Pharma Basel SwitzerlandM. de Gasparo, MG Consulting Rossemaison SwitzerlandB. Feng, Baker IDI Heart and Diabetes Institute PO Box 6492 St Kilda Road Central Melbourne 8008 VIC AustraliaM. C. Thomas, Baker IDI Heart and Diabetes Institute PO Box... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2936415 Tue, 27 Oct 2009 17:56:17 +0100 2936415 http://www.medworm.com/index.php?rid=2936416&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhv0184142k832k37%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1572-8Authors D. Simon, INSERM U-780 94807 Villejuif Cedex France Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2936416 Mon, 26 Oct 2009 17:58:59 +0100 2936416 http://www.medworm.com/index.php?rid=2928679&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0472380065531nn2%2F Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-009-1582-6Authors U. Grouven, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne GermanyL. G. Hemkens, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne GermanyR. Bender, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne GermanyP. T. Sawicki, Institute for Quality and Efficiency in Health Care (IQWiG) Dillenburger Str. 27 51105 Cologne Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2928679 Fri, 23 Oct 2009 18:52:27 +0100 2928679 http://www.medworm.com/index.php?rid=2928680&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7t861x3654425772%2F Conclusions/interpretation  Human beta cells, unlike those of young rodents, are long-lived. LB proportions in type 2 diabetes and obesity suggest that little adaptive change occurs in the adult human beta cell population, which is largely established by age 20 years. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1562-xAuthors M. Cnop, Université Libre de Bruxelles Laboratory of Experimental Medicine and Division of Endocrinology Brussels BelgiumS. J. Hughes, Churchill Hospital DRWF Islet Isolation Facility, Nuffield Department of Surgery Oxford UKM. Igoillo-Esteve, Université Libre de Bruxelles Laboratory of Experimental Medicine and Division of Endocrinology Brussels BelgiumM. B. Hoppa, Churchill Hospital Diabetes Research Laboratories, Oxf... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2928680 Fri, 23 Oct 2009 18:52:24 +0100 2928680 http://www.medworm.com/index.php?rid=2924246&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe24333muqn84x141%2F Abstract  Either endogenous or exogenous hyperinsulinaemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras proteins. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing to progression of cancer and atherosclerosis. This effect is specific to insulin, but is not related to the type of insulin used. The stimulatory effect of hyperinsulinaemia on farnesyltransferase in the presence of insulin resistance represents one potential mechanism responsible for mitogenicity and atherogenicity of insulin. Content Type Journal ArticleCategory For DebateDOI 10.1007/s00125-009-1558-6Authors ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2924246 Thu, 22 Oct 2009 18:55:08 +0100 2924246 http://www.medworm.com/index.php?rid=2924247&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm24714426641043t%2F Conclusions/interpretation  This study shows co-expression of multiple hormone genes in beta cells of adult mice as well as in embryos and neonates. This finding could: (1) represent residual expression from beta cell precursors; (2) result from alternative developmental pathways for beta cells; or (3) denote the differentiation potential of these cells. It may be linked to functional heterogeneity. This heterogeneity in gene expression may provide a means to characterise the functional, cellular and developmental heterogeneity seen in beta cells. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1570-xAuthors H. Katsuta, Joslin Diabetes Center Section on Islet Transplantation and Cell Biology One Joslin Place Boston MA 02215 USAT. Akashi, Joslin Dia... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2924247 Thu, 22 Oct 2009 18:55:07 +0100 2924247 http://www.medworm.com/index.php?rid=2921730&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F42t777p73g782194%2F Conclusions/interpretation  In this study, the largest study examining the role of sequence variants in LARS2 in type 2 diabetes susceptibility, we found no evidence to support previous data indicating a role in type 2 diabetes susceptibility. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1557-7Authors E. Reiling, Leiden University Medical Center (LUMC) Department of Molecular Cell Biology P.O. Box 9600 2300RC Leiden the NetherlandsB. Jafar-Mohammadi, University of Oxford, Churchill Hospital Oxford Center for Diabetes, Endocrinology and Metabolism Oxford UKE. van ’t Riet, VU University Medical Center EMGO Institute for Health and Care Research Amsterdam the NetherlandsM. N. Weedon, Peninsula Medical School Genetics of Complex Traits, Institute of ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2921730 Thu, 22 Oct 2009 06:01:30 +0100 2921730 http://www.medworm.com/index.php?rid=2921729&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc373n6158t865148%2F Conclusions/interpretation  CDA1 plays an important role in vascular ECM accumulation by amplifying TGF-β signalling. This is critical for the profibrotic effect of TGF-β in the vasculature. CDA1 is therefore a potential target for attenuating vascular ECM accumulation caused by enhanced TGF-β action, as seen in diabetic atherosclerosis. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1555-9Authors Y. Pham, Baker IDI Heart and Diabetes Institute Diabetes and Metabolism Division 75 Commercial Rd Melbourne Victoria 3004 AustraliaY. Tu, Baker IDI Heart and Diabetes Institute Diabetes and Metabolism Division 75 Commercial Rd Melbourne Victoria 3004 AustraliaT. Wu, Baker IDI Heart and Diabetes Institute Diabetes and Metabolism Division 75 Commercial Rd... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2921729 Thu, 22 Oct 2009 06:01:30 +0100 2921729 http://www.medworm.com/index.php?rid=2921731&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk54234515k92m214%2F Conclusions/interpretation  We propose that: (1) mitochondria undergo biogenesis in response to hyperglycaemia, but the increased biogenesis is insufficient to accommodate the metabolic load; (2) hyperglycaemia causes an excess of mitochondrial fission, creating small, damaged mitochondria; and (3) reduction of aberrant mitochondrial fission increases neuronal survival and indicates an important role for the fission–fusion equilibrium in the pathogenesis of diabetic neuropathy. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1553-yAuthors J. L. Edwards, University of Michigan Department of Neurology 5017 BSRB, 109 Zina Pitcher Place Ann Arbor MI 48109 USAA. Quattrini, San Raffaele Scientific Institute Department of Neurology and INSPE Milan ItalyS... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2921731 Wed, 21 Oct 2009 19:31:34 +0100 2921731 http://www.medworm.com/index.php?rid=2921732&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb738q361188j7146%2F Conclusions/interpretation  In adult non-human primates a decrement in fractional beta cell area of ∼50% or more leads to loss of glycaemic control. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1552-zAuthors Y. Saisho, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angeles CA 90024-2852 USAA. E. Butler, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angeles CA 90024-2852 USAE. Manesso, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angeles CA 90024-2852 USAR. Galasso, UCLA David Geffen School of Medicine Larry Hillblom Islet Research Center 900 Weyburn Place #A Los Angeles CA 90024-2852 USAL. Z... Diabetologia journals http://www.medworm.com/rss/comments.php?id=2921732 Wed, 21 Oct 2009 19:31:33 +0100 2921732 http://www.medworm.com/index.php?rid=2917820&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn084162868wp8055%2F Content Type Journal ArticleDOI 10.1007/BF03168181Authors T. M. Loftus, Johns Hopkins University School of Medicine Department of Biological Chemistry Baltimore Maryland USAD. G. Maggs, Yale University School of Medicine Endocrinology Division New Haven Connecticut USAM. D. Lane, Johns Hopkins University School of Medicine Department of Biological Chemistry Baltimore Maryland USA Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X Journal Volume Volume 40 Journal Issue Volume 40, Supplement 3 / March, 1997 (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=2917820 Wed, 21 Oct 2009 12:41:57 +0100 2917820