MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diabetologia' source. Wed, 08 Feb 2012 15:08:54 +0100 http://www.medworm.com/index.php?rid=5667691&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff1471w64481n3754%2F Abstract  According to our current understanding of insulin exocytosis, insulin granules dock on the plasma membrane, undergo priming and then wait for calcium-triggered fusion. In this issue of Diabetologia, Hoppa et al (doi 10.1007/s00125-011-2400-5) report that cholinergic stimulation induces granule–granule, or multivesicular, fusion to effect more efficient insulin release. Other exocytotic modes of insulin secretion, particularly those induced by incretin stimulation, include orderly granule fusion with granules already fused with the plasma membrane, called sequential exocytosis, and recruitment of newcomer granules to fuse with plasma membrane with minimal time for docking and priming. The molecular machineries that mediate these distinct exocytotic modes of granul... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5667691 Fri, 03 Feb 2012 17:11:34 +0100 5667691 http://www.medworm.com/index.php?rid=5667692&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr242037721717453%2F Conclusions/interpretation  The aggregation of biosynthetic hIAPP produced in islets induces beta cell apoptosis, at least partially, via Fas upregulation and the Fas-mediated apoptotic pathway. Deletion of Fas protects islet beta cells from the cytotoxic effects of endogenously secreted (and exogenously applied) hIAPP. Content Type Journal ArticleCategory ArticlePages 1-13DOI 10.1007/s00125-012-2451-2Authors Y. J. Park, Department of Surgery, Faculty of Medicine, University of British Columbia, Jim Pattison Pavilion, Vancouver General Hospital, 910 W 10th Ave, Vancouver, BC, Canada V5Z 4E3S. Lee, Department of Surgery, Faculty of Medicine, University of British Columbia, Jim Pattison Pavilion, Vancouver General Hospital, 910 W 10th Ave, Vancouver, BC, Canada V5Z 4E3T... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5667692 Thu, 02 Feb 2012 18:12:53 +0100 5667692 http://www.medworm.com/index.php?rid=5667694&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8251h67v83762456%2F Conclusions/interpretation  Diabetes was a strong predictor of PAD after initiation of haemodialysis therapy in patients with ESRD. In addition, higher HbA1c levels were associated with increased risk of developing PAD and requiring limb amputation in such diabetic populations. Content Type Journal ArticleCategory ArticlePages 1-6DOI 10.1007/s00125-012-2473-9Authors H. Ishii, Department of Cardiology, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya, 466-8550 JapanY. Kumada, Department of Cardiology, Nagoya Kyoritsu Hospital, Nagoya, JapanH. Takahashi, Department of Cardiology, Nagoya Kyoritsu Hospital, Nagoya, JapanT. Toriyama, Department of Cardiology, Nagoya Kyoritsu Hospital, Nagoya, JapanT. Aoyama, Department of Cardiology, Nagoya... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5667694 Thu, 02 Feb 2012 06:55:33 +0100 5667694 http://www.medworm.com/index.php?rid=5667693&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg2685xt7r738m873%2F Content Type Journal ArticleCategory CommentaryPages 1-4DOI 10.1007/s00125-012-2478-4Authors D. Meyre, Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning & Discovery, McMaster University, Room 3205, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5667693 Thu, 02 Feb 2012 06:55:33 +0100 5667693 http://www.medworm.com/index.php?rid=5667695&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy77468x8543751r7%2F Conclusion/interpretation  The pattern of antibodies, the postdiabetic loss or persistence as well as the prediabetic absence or presence of antibodies influence LADA phenotypes. Time-dependent presence or absence of antibodies adds new modalities to the heterogeneity of LADA. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-012-2463-yAuthors E. P. Sørgjerd, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), HUNT Research Centre, Forskningsveien 2, 7600 Levanger, NorwayF. Skorpen, Department of Laboratory Medicine, Children’s and Women’s Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayK. Kvaløy, HUNT Research Centre,... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5667695 Thu, 02 Feb 2012 06:55:32 +0100 5667695 http://www.medworm.com/index.php?rid=5660399&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffx7086h424653406%2F LIST OF REFEREES Content Type Journal ArticleCategory List of RefereeesPages 1-2DOI 10.1007/s00125-012-2470-z Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5660399 Wed, 01 Feb 2012 17:13:41 +0100 5660399 http://www.medworm.com/index.php?rid=5660400&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj177502j71564714%2F Conclusion  The age period 9 months to 2 years is associated with a high incidence of activation of type 1 diabetes-associated autoimmunity in genetically at-risk children and should be targeted for effective primary prevention strategies. Content Type Journal ArticleCategory ArticlePages 1-7DOI 10.1007/s00125-012-2472-xAuthors A.-G. Ziegler, Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, GermanyE. Bonifacio, Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Neuherberg, Germanythe BABYDIAB-BABYDIET Study Group Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5660400 Tue, 31 Jan 2012 07:12:31 +0100 5660400 http://www.medworm.com/index.php?rid=5648770&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2u9h173087116lw5%2F Conclusions/interpretation  Among patients with type 2 diabetes, a higher resting heart rate is associated with an increased risk of death and cardiovascular complications. It remains unclear whether a higher heart rate directly mediates the increased risk or is a marker for other factors that determine a poor outcome. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-012-2471-yAuthors G. S. Hillis, The George Institute for Global Health, King George V Building, Royal Prince Alfred Hospital, Sydney, NSW 2050, AustraliaM. Woodward, The George Institute for Global Health, King George V Building, Royal Prince Alfred Hospital, Sydney, NSW 2050, AustraliaA. Rodgers, The George Institute for Global Health, King George V Building, Royal Prince Alfred H... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648770 Sat, 28 Jan 2012 16:52:22 +0100 5648770 http://www.medworm.com/index.php?rid=5648771&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fppvx8725782136k2%2F Conclusion/interpretation  Insulin resistance and IGT, representing two stages in the path towards diabetes, are associated with differential reductions in the incretin effect seen before the development of IGT and overt type 2 diabetes. The reduction is unrelated to secretion of incretin hormones, but is related to insulin resistance and subtle beta cell defects, and is further aggravated on development of IGT. Trial registration:  ClinicalTrials.gov NCT00784745. Funding:  This study was supported by a grant from the Novo Nordisk Foundation. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-012-2459-7Authors D. H. Jensen, Department of Endocrinology, Bispebjerg University Hospital, Bispebjerg Bakke 23, DK-240... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648771 Sat, 28 Jan 2012 16:52:19 +0100 5648771 http://www.medworm.com/index.php?rid=5648772&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc5krn1t1104nuk3k%2F Conclusions/interpretation  In a ‘real-world’ setting, prescription of an energy-reduced low-fat diet, with either increased protein or carbohydrate, results in similar modest losses in weight and waist circumference over 2 years. Trial registration:  Australia New Zealand Clinical Trials Register ACTRN12606000490572 Funding:  The Health Research Council of New Zealand (06/337). Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-012-2461-0Authors J. D. Krebs, Department of Medicine, University of Otago, Wellington, New ZealandC. R. Elley, School of Population Health, University of Auckland, Auckland, New ZealandA. Parry-Strong, Department of Medicine, University of Otago, Wellington, New ZealandH. Lunt, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648772 Sat, 28 Jan 2012 06:42:35 +0100 5648772 http://www.medworm.com/index.php?rid=5648773&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1137321j0213241%2F Conclusions/interpretation  In conclusion, pancreatic diabetes probably develops after a reduction in beta cell area of ~65%. Post-challenge glucose excursions are much more closely related to pancreatic beta cell area than to fasting glycaemia, thereby underlining the usefulness of the OGTT in patients with pancreatic disorders. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-012-2466-8Authors J. J. Meier, Diabetes Division, Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr. 56, 44791 Bochum, GermanyT. G. K. Breuer, Diabetes Division, Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr. 56, 44791 Bochum, GermanyR. C. Bonadonna, Department of Medicine, Division of Endocrinology and Metabo... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648773 Fri, 27 Jan 2012 17:56:33 +0100 5648773 http://www.medworm.com/index.php?rid=5648776&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6443xu777m05841%2F Conclusions/interpretation  Our data suggest that increased glycolytic and decreased mitochondrial protein abundance together with a shift in muscle properties towards a fast-twitch pattern in the absence of marked changes in fibre-type distribution contribute to insulin resistance in obesity with and without type 2 diabetes. The roles of several differentially expressed or post-translationally modified proteins remain to be elucidated. Content Type Journal ArticleCategory ArticlePages 1-14DOI 10.1007/s00125-012-2456-xAuthors J. Giebelstein, Medizinische Klinik I, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Klinikum der Ruhr Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, GermanyG. Poschmann, Medizinisches Proteom-Center, Ruhr Univ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648776 Thu, 26 Jan 2012 16:44:55 +0100 5648776 http://www.medworm.com/index.php?rid=5648775&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx062187r38111730%2F Conclusions/interpretation  We showed that the effects of electrical pulse stimulation on skeletal muscle cells were similar to the effect of exercise on skeletal muscle in vivo in terms of enhanced AMPK activation and IL-6 secretion. In our model, muscle contractile activity eliminates insulin resistance by blocking pro-inflammatory signalling pathways. This novel model therefore provides a unique tool for investigating the molecular mechanisms that mediate the beneficial effects of muscle contraction. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-012-2454-zAuthors S. Lambernd, Paul-Langerhans-Group, Integrative Physiology, German Diabetes Center, Auf´m Hennekamp 65, 40225 Duesseldorf, GermanyA. Taube, Paul-Langerhans-Group, Integrative ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648775 Thu, 26 Jan 2012 16:44:55 +0100 5648775 http://www.medworm.com/index.php?rid=5648774&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff61k0722860530t8%2F Abstract  C3 is the central component of the complement system and activation of C3 via any of the three major activation pathways—the classical, the lectin and the alternative pathways—results in initiation of the terminal complement pathway and release of the anaphylatoxin C3a. Both terminal pathway activation and signalling of C3a and its inactivation product C3a-desarg via the C3a receptor and C5a-like receptor 2, respectively, can induce inflammatory, immunomodulatory and metabolic responses. C3 has been implicated in metabolic disorders, notably adiposity, dyslipidaemia, insulin resistance, liver dysfunction and diabetes, and C3 is increasingly recognised as a cardiometabolic risk factor. C3 may play a role in the macrovascular, as well as microvascular, complicat... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648774 Thu, 26 Jan 2012 16:44:55 +0100 5648774 http://www.medworm.com/index.php?rid=5648777&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft1712k67n64641kr%2F Conclusions/interpretation  Weight loss is safe, and improves liver histology and cardio-metabolic profile. For patients not responding to lifestyle intervention, pioglitazone improves histological disease activity, slows fibrosis progression and extensively ameliorates cardio-metabolic endpoints. Further randomised controlled trials (RCTs) of adequate size and duration will assess long-term safety and efficacy of proposed treatments on clinical outcomes. Content Type Journal ArticleCategory Systematic reviewPages 1-20DOI 10.1007/s00125-011-2446-4Authors G. Musso, Gradenigo Hospital, C.so Regina Margherita 8, 10132 Turin, ItalyM. Cassader, Department of Internal Medicine, University of Turin, Turin, ItalyF. Rosina, Gradenigo Hospital, C.so Regina Margherita 8, 10132... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648777 Thu, 26 Jan 2012 06:44:13 +0100 5648777 http://www.medworm.com/index.php?rid=5648778&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg1g558u40t582k4h%2F Conclusions/interpretation  The results for the novel GWA study-identified loci are genuine and not due to population stratification. The next step, namely correlation of the most disease-associated genotypes with phenotypes, such as RNA and protein expression analyses for the candidate genes within or near each of the susceptibility regions, can now proceed. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00125-012-2450-3Authors J. D. Cooper, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 0YX UKJ. M. M. Howson, Juvenile Diabetes Research Foundation/Wellcom... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5648778 Wed, 25 Jan 2012 18:08:14 +0100 5648778 http://www.medworm.com/index.php?rid=5638933&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F223xx0777x422783%2F Conclusions/interpretation  Diabetic patients can be characterised by an increased formation of TPINT and MG. The 25-fold increase of MG in type 1 and the 15-fold increase in type 2 diabetes, together with a several-fold increase in TPINT and decreased glyceraldehyde-3-phosphate dehydrogenase activity even under normal glucose conditions, imply that normalising glucose level cannot completely prevent late diabetic complications until this acquired error of metabolism has been restored. Content Type Journal ArticleCategory ArticlePages 1-5DOI 10.1007/s00125-012-2452-1Authors T. Fleming, Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, GermanyJ. Cuny, Department of Medicine I and Clinical Chemistry, University of Hei... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5638933 Tue, 24 Jan 2012 07:29:37 +0100 5638933 http://www.medworm.com/index.php?rid=5638932&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fan8246211432273l%2F Abstract  Since the work of Eriksson and Lindgärde, published over two decades ago (Diabetologia 1991;34:891–898), we have known that type 2 diabetes can be prevented or delayed by supervised lifestyle interventions (physical exercise and diet modification) in persons at risk of the disease. Here we discuss a novel, time-efficient approach to physical exercise prescription, low-volume, high-intensity interval training (LVHIT), and its efficacy for inducing a range of health benefits in a variety of populations at risk of inactivity-related diseases. We look to the future and suggest that current guidelines for exercise may need to be revised to include different training techniques to deliver the optimum exercise prescription. Indeed, we predict that subsequent exercise g... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5638932 Tue, 24 Jan 2012 07:29:37 +0100 5638932 http://www.medworm.com/index.php?rid=5638934&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9th2670022m743v8%2F Conclusions/interpretation  No difference was found in serum 25(OH)D concentrations during first trimester of pregnancy between mothers whose children later on developed type 1 diabetes, and mothers of non-diabetic ‘ healthy’ children of the same age. It is difficult to detect possible effects of mothers’ vitamin D deficiency during early pregnancy on the development of type 1 diabetes in the offspring in this population, as such a large proportion of mothers were vitamin D-deficient or -insufficient. Content Type Journal ArticleCategory Short CommunicationPages 1-4DOI 10.1007/s00125-012-2458-8Authors M. E. Miettinen, Department of Public Health, University of Helsinki, Helsinki, FinlandL. Reinert, Diabetes Prevention Unit, National Institute for Health and We... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5638934 Tue, 24 Jan 2012 07:29:36 +0100 5638934 http://www.medworm.com/index.php?rid=5638935&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqjl3718653044133%2F Conclusions/interpretation  We demonstrate that MSCs are capable of regulating Teff and Treg cells differentially in vitro. MSCs inhibit Teff cells by inducing apoptosis and impairing the proliferative response to IL-2 in Teff cells, but favour the survival and expansion of Treg cells. This result is further demonstrated in mice that have undergone allogeneic islet transplantation, in which MSCs suppress alloreactive Teff cells while favouring the induction of Treg cells, thus protecting the islet allografts from rejection. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2433-9Authors D. M. Xu, Department of Haematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5638935 Tue, 24 Jan 2012 07:29:35 +0100 5638935 http://www.medworm.com/index.php?rid=5620661&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmnqm523q1564m872%2F Abstract  The mechanisms responsible for the accelerated atherosclerosis observed in type 2 diabetes are not fully understood. One of the earliest events in the development of atherosclerosis is endothelial dysfunction, namely, a reduction in nitric oxide (NO) synthesis or its bioavailability within the peri-endothelial environment, where it is responsible for maintenance of vascular tissue integrity. The clinical evaluation of this pathway is hampered by the fact that in vivo NO cannot be directly measured; however, exploiting a novel, complex and elegant experimental setup, McVeigh and co-workers (Diabetologia 1992;35:771–776) were the first to document that NO bioavailability in type 2 diabetic patients is indeed reduced. In this edition of ‘Then and now’ that pape... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5620661 Fri, 20 Jan 2012 07:03:08 +0100 5620661 http://www.medworm.com/index.php?rid=5620662&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32g20118605j567q%2F Conclusions/interpretation  Visual sensitivity reduces disproportionately with increasing eccentricity in type 2 diabetic patients with peripheral neuropathy. This sensitivity reduction within the central 30° of visual field may be indicative of more consequential loss in the far periphery. Content Type Journal ArticleCategory ArticlePages 1-7DOI 10.1007/s00125-012-2457-9Authors G. P. Sampson, School of Optometry and Vision Science and Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059 QLD, AustraliaA. M. Shahidi, School of Optometry and Vision Science and Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059 QLD, AustraliaD. Vagenas, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5620662 Thu, 19 Jan 2012 06:53:41 +0100 5620662 http://www.medworm.com/index.php?rid=5620664&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl17t27kv15676003%2F Conclusions  We showed that dyslipidaemia is associated with major changes in both lipid class and lipid species composition in VLDL and LDL from women with type 2 diabetes. In addition, we identified specific molecular lipid species that both correlate with clinical variables and are proinflammatory. Our study thus shows the potential of advanced lipidomic methods to further understand the pathophysiology of type 2 diabetes. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2444-6Authors M. Ståhlman, Sahlgrenska Centre for Cardiovascular and Metabolic Research/Wallenberg Laboratory and Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, S-413 45 Gothenburg, SwedenH. T. Pham, School of Chemistry, University of ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5620664 Wed, 18 Jan 2012 06:51:44 +0100 5620664 http://www.medworm.com/index.php?rid=5620663&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F560111j44n531411%2F Conclusions/interpretation  These data indicate that both cellular localisation and composition of DAG influence the relationship to insulin sensitivity. Our results suggest that only saturated DAG in skeletal muscle membranes are related to insulin resistance in humans. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2419-7Authors B. C. Bergman, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave, PO Box 6511, MS 8106, Aurora, CO 80045, USAD. M. Hunerdosse, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave, PO Box 6511, MS 8106, Aurora, CO 80045, USAA. Kerege, Division of Endocrinology, Metabolism, and Di... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5620663 Wed, 18 Jan 2012 06:51:44 +0100 5620663 http://www.medworm.com/index.php?rid=5620667&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft21151273511m06n%2F Conclusions/interpretation  The common iDEND mutation Kir6.2-V59M decreases ATP block of cardiac KATP channels but was without obvious effect on heart function, suggesting that metabolic changes fail to open the mutated channel to an extent that affects function (at least in the absence of ischaemia). This may have implications for the choice of sulfonylurea used to treat neonatal diabetes. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2428-6Authors R. Clark, Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford, OX1 3PT UKR. Männikkö, Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford, OX1 3PT UKD. J. Stuckey, Henry Wellcome... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5620667 Wed, 18 Jan 2012 06:51:41 +0100 5620667 http://www.medworm.com/index.php?rid=5620666&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3l8w35647710054q%2F Conclusions/interpretation  A major reason for the lower mean granule number/rat beta cell relative to previous accounts is a reduced estimation of the mean beta cell volume. These findings imply that each granule contains about twofold more insulin, while its exocytosis increases membrane capacitance about twofold less than assumed previously. Our integrated approach defines new standards for quantitative image analysis of beta cells and could be applied to other cellular systems. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2438-4Authors E. Fava, Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, GermanyJ. Dehghany, Department of Systems Immunology, Helmholtz Centre for Infection Research (HZI), Inhoffenstr. 7, 3... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5620666 Wed, 18 Jan 2012 06:51:41 +0100 5620666 http://www.medworm.com/index.php?rid=5620665&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb34t8q7204655501%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00125-012-2453-0Authors P. R. Patel, Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail Stop 1009, Toledo, OH 43614, USAS. K. Ramakrishnan, Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail Stop 1009, Toledo, OH 43614, USAM. K. Kaw, Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail Stop 1009, Toledo, OH 43614, USAC. K. Raphael, Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5620665 Wed, 18 Jan 2012 06:51:41 +0100 5620665 http://www.medworm.com/index.php?rid=5598389&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fev58w3r534648205%2F Conclusions/interpretation  Nano-scale encapsulation offers localised immune protection for implanted islets, and may be able to limit early allograft loss and extend survival of transplanted islets. This versatile coating scheme has the potential to be integrated with tolerance induction mechanisms, thereby achieving long-term success in islet transplantation. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2431-yAuthors Z.-l. Zhi, Diabetes Research Group, King’s College London School of Medicine, Guy’s Hospital Campus, London, SE1 1UL UKA. Kerby, Diabetes Research Group, King’s College London School of Medicine, Guy’s Hospital Campus, London, SE1 1UL UKA. J. F. King, Diabetes Research Group, King’s College London School of Med... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598389 Sat, 14 Jan 2012 06:54:48 +0100 5598389 http://www.medworm.com/index.php?rid=5598390&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6467114755hr3669%2F Conclusions/interpretation  Altogether, our data suggest TXNIP as a novel mediator of GC-induced apoptosis in beta cells and further contribute to our understanding of beta cell death pathways. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2422-zAuthors E. Reich, Department of Endocrinology, Hadassah University Hospital, PO Box 12 000, 91120 Jerusalem, IsraelA. Tamary, Department of Endocrinology, Hadassah University Hospital, PO Box 12 000, 91120 Jerusalem, IsraelR. Vogt Sionov, Department of Endocrinology, Hadassah University Hospital, PO Box 12 000, 91120 Jerusalem, IsraelD. Melloul, Department of Endocrinology, Hadassah University Hospital, PO Box 12 000, 91120 Jerusalem, Israel Journal DiabetologiaOnline ISSN 1432-0428Print I... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598390 Sat, 14 Jan 2012 06:54:47 +0100 5598390 http://www.medworm.com/index.php?rid=5598391&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F508937335r381516%2F Conclusions/interpretation  No one PROM was identified as a ‘gold standard’ for assessing HRQOL in diabetes-related foot disease. Specific areas for further development include the most valid HRQOL PROM with disease-specific content; HRQOL outcomes in minor and major amputations and the role of HRQOL tools in routine clinical care. Content Type Journal ArticleCategory Systematic reviewPages 1-14DOI 10.1007/s00125-011-2372-5Authors F. R. A. Hogg, St George’s Vascular Institute, St James Wing, St George’s Healthcare NHS Trust, 4th Floor, Blackshaw Road, London, SW17 0QT UKG. Peach, St George’s Vascular Institute, St James Wing, St George’s Healthcare NHS Trust, 4th Floor, Blackshaw Road, London, SW17 0QT UKP. Price, School of Healthcare Studies, Cardiff Uni... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598391 Sat, 14 Jan 2012 06:54:45 +0100 5598391 http://www.medworm.com/index.php?rid=5598393&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2up3217407g37072%2F Conclusions/interpretation  Infusion of exenatide in male type 2 diabetic patients with CHF increased the CI as a result of chronotropy, with concomitant favourable effects on PCWP and reasonable tolerability of the drug. The clinical implications of using exenatide in patients with CHF are still not clear and further studies are warranted. Trial registration:   www.isrctn.org/ISRCTN47533126 Funding:  This study was funded through the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and the Karolinska Institute, by the Swedish Society for Medical Research, the Swedish Society of Medicine, Stiftelsen Serafimerlasarettet, the Swedish Heart and Lung foundation, Eli Lilly Amylin Alliance, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598393 Fri, 13 Jan 2012 16:55:51 +0100 5598393 http://www.medworm.com/index.php?rid=5598392&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F313g6g4625029hw6%2F Conclusions/interpretation  Differences in IR in women with and without PCOS were not explained by differences in skeletal muscle lipid or mitochondrial parameters. Improvements in IR with exercise were dissociated from mitochondrial parameters. CT muscle attenuation suggested a differential capacity of PCOS muscle to store lipid compared with non-PCOS. Trial registration:  Clinicaltrials.gov ISRCTN84763265 Funding:  National Health & Medical Research Council (Grant number 606553), Monash University and The Jean Hailes Foundation. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2442-8Authors S. K. Hutchison, Jean Hailes Foundation Research, School of Public Health and Preventative Medicine, Monash Univers... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598392 Fri, 13 Jan 2012 16:55:51 +0100 5598392 http://www.medworm.com/index.php?rid=5598394&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh0897x4541619001%2F Abstract  This edition of ‘Then and now’ re-examines Lise Heding’s very highly cited paper ‘Radioimmunological determination of human C-peptide in serum’, which was published in Diabetologia in 1975. We show how this article and other related articles by Heding contributed to heightened respect for C-peptide (and transformation of Heding’s research programme). Initially thought of as an inert discard, C-peptide in blood is now recognised as an excellent surrogate measure of insulin secretion under a wide range of conditions. The assay is especially valuable for acute ascertainment of the insulin secretory capabilities of patients with type 1 diabetes or of transplanted beta cells. The assay is also being used to monitor endogenous beta cell loss or in vivo expans... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598394 Fri, 13 Jan 2012 16:55:48 +0100 5598394 http://www.medworm.com/index.php?rid=5598395&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg81145470x341489%2F Content Type Journal ArticleCategory CommentaryPages 1-2DOI 10.1007/s00125-011-2449-1Authors P. Serup, Department of Developmental Biology, Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598395 Fri, 13 Jan 2012 16:55:46 +0100 5598395 http://www.medworm.com/index.php?rid=5598396&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb8r722720xjm6743%2F Conclusions/interpretation  Treatment with Alo and Alo/Pio produced significant reductions in postprandial TG and TG-rich lipoproteins, contributing to an improved overall cardiometabolic risk profile in type 2 diabetes. The data support the concept that incretins not only modulate glucose metabolism but also influence chylomicron metabolism in intestinal cells. Trial registration:  ClinicalTrials.gov number NCT00655863. Funding:  The study was funded by Takeda Global Research & Development. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2447-3Authors B. Eliasson, Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sah... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5598396 Thu, 12 Jan 2012 06:42:49 +0100 5598396 http://www.medworm.com/index.php?rid=5582816&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1342v46x1h743880%2F Conclusions/interpretation  These observations suggest that insulin resistance is not induced by fat accumulation per se, but rather by the inflammation induced by ectopic fat. CHOP may play a key role in the crosstalk between excessive fat deposition and induction of inflammation-mediated insulin resistance. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2427-7Authors M. Maris, Laboratory for Experimental Medicine and Endocrinology (LEGENDO), Catholic University of Leuven, Herestraat 49 bus 902, 3000 Leuven, BelgiumL. Overbergh, Laboratory for Experimental Medicine and Endocrinology (LEGENDO), Catholic University of Leuven, Herestraat 49 bus 902, 3000 Leuven, BelgiumC. Gysemans, Laboratory for Experimental Medicine and Endocrinology (LE... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582816 Wed, 11 Jan 2012 17:54:03 +0100 5582816 http://www.medworm.com/index.php?rid=5582817&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg33944x71u470613%2F Conclusions  Diabetes screening resulted in cases being identified on average 3.3 years earlier, a difference significantly shorter than previous estimates. Earlier diagnosis did not appear to impact on health outcomes. Further evidence is needed to justify the introduction of population-based screening. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2441-9Authors M. Rahman, General Practice and Primary Care Research Unit, University of Cambridge, Cambridge, UKR. K. Simmons, MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ UKS. H. Hennings, MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ UKN... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582817 Wed, 11 Jan 2012 17:54:02 +0100 5582817 http://www.medworm.com/index.php?rid=5582821&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fex392761n0413507%2F Conclusions/interpretation  These data suggest that the negative effects of GDM combined with obesity during pregnancy may be greater in NHB than in NHW individuals. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2430-zAuthors K. J. Hunt, Department of Medicine/Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 302, P.O. Box 250835, Charleston, SC 29425, USAN. M. Marlow, Department of Medicine/Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 302, P.O. Box 250835, Charleston, SC 29425, USAM. Gebregziabher, Department of Medicine/Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 302, P.O. Box 250835, Charles... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582821 Wed, 11 Jan 2012 17:54:00 +0100 5582821 http://www.medworm.com/index.php?rid=5582820&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn863g24pr4880377%2F Content Type Journal ArticleCategory LetterPages 1-2DOI 10.1007/s00125-011-2448-2Authors R. Ruiter, Department of Epidemiology, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, the NetherlandsL. E. Visser, Department of Epidemiology, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, the NetherlandsB. H. Ch. Stricker, Department of Epidemiology, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582820 Wed, 11 Jan 2012 17:54:00 +0100 5582820 http://www.medworm.com/index.php?rid=5582819&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx00181644w50w501%2F Conclusions/interpretation  Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases serum IGF-I bioactivity in a similar manner. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2435-7Authors A. J. Varewijck, Department of Internal Medicine, Division of Endocrinology, Erasmus MC, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, the NetherlandsJ. A. M. J. L. Janssen, Department of Internal Medicine, Division of Endocrinology, Erasmus MC, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, the NetherlandsM. Vähätalo, City of Turku Health Centre, Turku, FinlandL. J. Hofland, Department of Internal Medicine, Division of Endocrinology, Erasmus MC, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, t... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582819 Wed, 11 Jan 2012 17:54:00 +0100 5582819 http://www.medworm.com/index.php?rid=5582818&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp362r471xm915613%2F Conclusions/interpretation  We report here Dhh/Ihh-dependent activation of hedgehog targets during pancreatic exocrine cell metaplasia in vitro and a persistent inhibitory function of hedgehog signalling in a model of postnatal beta cell differentiation. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2434-8Authors J. K. Mfopou, Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, BelgiumL. Baeyens, Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, BelgiumL. Bouwens, Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium Journ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582818 Wed, 11 Jan 2012 17:54:00 +0100 5582818 http://www.medworm.com/index.php?rid=5582823&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff761425l02w3v823%2F Conclusions/interpretation  These findings suggest that chronic activation of glucokinase preserves beta cell mass and delays disease in the ZDF rat, a model of insulin resistance and progressive beta cell failure. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2439-3Authors M. Futamura, Banyu Tsukuba Research Institute, MSD K.K., 3 Okubo, Tsukuba, Ibaraki 300-26, JapanJ. Yao, Departments of Metabolic Disorders and Pharmacology, Merck Sharp & Dohme Corp., Whitehouse Station, NJ 0889, USAX. Li, Departments of Metabolic Disorders and Pharmacology, Merck Sharp & Dohme Corp., Whitehouse Station, NJ 0889, USAR. Bergeron, Departments of Metabolic Disorders and Pharmacology, Merck Sharp & Dohme Corp., Whitehouse Station, NJ 0889, USAJ.-L. Tran, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582823 Wed, 11 Jan 2012 06:55:41 +0100 5582823 http://www.medworm.com/index.php?rid=5582822&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy15462p42177u04r%2F Conclusions/interpretation  This large trial shows a relationship between changes in physical and mental health-related QoL measures and volume of physical activity/exercise, with supervised exercise training also providing volume-independent benefits. Trial registration:  ISRCTN-04252749 Funding:  The study was funded by Lifescan SrL, Novo Nordisk Ltd, Bristol Myers Squibb Italy, Technogym SpA and Cosmed SrL. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2425-9Authors A. Nicolucci, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S. Maria Imbaro, Chieti, ItalyS. Balducci, Department of Clinical and Molecular Medicine, “La Sapienza” University of Rome, Via di Grottaros... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582822 Wed, 11 Jan 2012 06:55:41 +0100 5582822 http://www.medworm.com/index.php?rid=5582824&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F07636665l881x772%2F Conclusions  The score can be used to reliably identify those with undiagnosed IGR and type 2 diabetes in multiethnic populations. This is the first score developed taking into account HbA1c in the diagnosis of type 2 diabetes. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2432-xAuthors L. J. Gray, Department of Health Sciences, University of Leicester, 22-28 Princess Road West, Leicester, LE1 6TP UKM. J. Davies, Department of Cardiovascular Sciences, University of Leicester, Leicester, UKS. Hiles, Department Diabetes Research, University Hospitals of Leicester, Leicester, UKN. A. Taub, Department of Health Sciences, University of Leicester, 22-28 Princess Road West, Leicester, LE1 6TP UKD. R. Webb, Department of Cardiovascular Sciences, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582824 Tue, 10 Jan 2012 06:41:48 +0100 5582824 http://www.medworm.com/index.php?rid=5582825&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq863850361335117%2F Conclusions/interpretation  The ghrelin gene-derived peptides and Ex-4 exert cytoprotective effects in islet MECs. The anti-apoptotic effects involve phosphoinositide 3-kinase (PI3K)/Akt, ERK1/2 and cAMP/PKA pathways. These peptides could therefore represent a potential tool to improve islet vascularisation and, indirectly, islet cell function. Content Type Journal ArticleCategory ArticlePages 1-13DOI 10.1007/s00125-011-2423-yAuthors E. Favaro, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, ItalyR. Granata, Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, University of Turin, Turin, ItalyI. Miceli, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582825 Mon, 09 Jan 2012 19:38:25 +0100 5582825 http://www.medworm.com/index.php?rid=5582826&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F85m65h6q2vq43567%2F Conclusions/interpretation  The presence of antibodies against any of five serotypes of Coxsackievirus B was not associated with incident type 2 diabetes. Content Type Journal ArticleCategory Short CommunicationPages 1-4DOI 10.1007/s00125-011-2443-7Authors E. Gkrania-Klotsas, Medical Research Council Epidemiology Unit, Addenbrooke’s Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ UKC. Langenberg, Medical Research Council Epidemiology Unit, Addenbrooke’s Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ UKS. Tauriainen, Department of Virology, University of Tampere, Tampere, FinlandS. J. Sharp, Medical Research Council Epidemiology Unit, Addenbrooke’s Hospital, Box 285, Hills Road, Cambridge, CB2 0QQ UKR. Luben, Department of Public Health and Primary Care, Instit... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582826 Mon, 09 Jan 2012 19:38:24 +0100 5582826 http://www.medworm.com/index.php?rid=5582828&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffvt26g21m0374649%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00125-011-2420-1Authors F. L. Game, Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, Nottingham University Hospitals Trust, City Hospital Campus, Hucknall Road, Nottingham, NG5 1PB UKR. Catlow, East Lancashire Healthcare Trust, Blackburn, UKG. R. Jones, East Lancashire Healthcare Trust, Blackburn, UKM. E. Edmonds, Kings College Hospital, London, UKE. B. Jude, Tameside General Hospital, Tameside, UKG. Rayman, Ipswich Hospital, Ipswich, UKW. J. Jeffcoate, Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, Nottingham University Hospitals Trust, City Hospital Campus, Hucknall Road, Nottingham, NG5 1PB UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582828 Mon, 09 Jan 2012 19:38:23 +0100 5582828 http://www.medworm.com/index.php?rid=5582827&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy113u4k51722xq58%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00125-011-2406-zAuthors V. B. Matthews, Cellular and Molecular Metabolism Laboratory, Diabetes and Metabolism Division, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, AustraliaM.-B. Åström, The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet—Section 7641, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, DenmarkM. H. S. Chan, Cellular and Molecular Metabolism Laboratory, Diabetes and Metabolism Division, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, AustraliaC. R. Bruce, Cellular and Molecular Metabolism Laboratory, Diabetes and Metabolism Division,... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5582827 Mon, 09 Jan 2012 19:38:23 +0100 5582827 http://www.medworm.com/index.php?rid=5572577&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh721q55g62014150%2F Conclusions/interpretation  There was no excess risk of cancer in type 2 diabetic patients on insulin glargine alone compared with those on human insulin alone. The overall risk of death or cancer in patients on insulin glargine was about half that of patients on human insulin, thereby excluding a competitive risk bias. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2429-5Authors P. Blin, Department of Pharmacology, Bat du Tondu, Case 40, Université de Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, FranceR. Lassalle, Department of Pharmacology, Bat du Tondu, Case 40, Université de Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, FranceC. Dureau-Pournin, Department of Pharmacology, Bat du Tondu, Case 40, Université de Bordeaux, 146 Rue... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5572577 Fri, 06 Jan 2012 06:43:40 +0100 5572577 http://www.medworm.com/index.php?rid=5572580&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86560818232w172r%2F Conclusions/interpretation  GRB10 is critically involved in alpha cell survival and, as a result, plays an important role in regulating basal glucagon secretion and glucose tolerance in adult mice. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2414-zAuthors B. Doiron, Diabetes Division, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, TX 78299, USAW. Hu, Diabetes Division, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, TX 78299, USAL. Norton, Diabetes Division, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, TX 78299, USAR. A. DeFronzo, Diabetes Division,... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5572580 Fri, 06 Jan 2012 06:43:39 +0100 5572580 http://www.medworm.com/index.php?rid=5572579&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg148308770265350%2F Content Type Journal ArticleCategory LetterPages 1-2DOI 10.1007/s00125-011-2437-5Authors H. Sourij, Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UKR. R. Holman, Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5572579 Fri, 06 Jan 2012 06:43:39 +0100 5572579 http://www.medworm.com/index.php?rid=5572578&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq33885194q475080%2F Content Type Journal ArticleCategory LetterPages 1-2DOI 10.1007/s00125-011-2436-6Authors B. Carstensen, Steno Diabetes Center, Niels Steensens Vej 2, 2829 Gentofte, Denmark Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5572578 Fri, 06 Jan 2012 06:43:39 +0100 5572578 http://www.medworm.com/index.php?rid=5572581&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm108137h3684u365%2F Conclusions/interpretation  We have developed clinical prediction models that calculate an individual’s probability of having MODY. This allows an improved and more rational approach to determine who should have molecular genetic testing. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2418-8Authors B. M. Shields, Peninsula NIHR Clinical Research Facility, Peninsula Medical School, University of Exeter, Barrack Road, Exeter, EX2 5DW UKT. J. McDonald, Royal Devon and Exeter NHS Foundation Trust, Exeter, UKS. Ellard, Royal Devon and Exeter NHS Foundation Trust, Exeter, UKM. J. Campbell, School of Health and Related Research, University of Sheffield, Sheffield, UKC. Hyde, Peninsula Technology Assessment Group, Peninsula Medical School, Unive... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5572581 Wed, 04 Jan 2012 17:00:50 +0100 5572581 http://www.medworm.com/index.php?rid=5572582&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhr02g5021205n373%2F Conclusions/interpretation  We provide compelling evidence that TGF-β1-induced EMT instigates a loss of E-cadherin, cell adhesion and ultimately of connexin-mediated cell communication in the proximal tubule under diabetic conditions; these changes occur ahead of overt signs of renal damage. Content Type Journal ArticleCategory ArticlePages 1-13DOI 10.1007/s00125-011-2409-9Authors C. E. Hills, School of Life Sciences, University of Warwick, Coventry, CV4 7AL UKE. Siamantouras, School of Engineering, University of Warwick, Coventry, UKS. W. Smith, Department of Renal Immunobiology, Institute of Biomedical Research, University of Birmingham, Birmingham, UKP. Cockwell, Department of Renal Immunobiology, Institute of Biomedical Research, University of Birmingham, Birming... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5572582 Wed, 04 Jan 2012 07:01:30 +0100 5572582 http://www.medworm.com/index.php?rid=5560743&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg2ut02p756625g11%2F Conclusions/interpretation  AMPK phosphorylates and activates the insulin receptor, providing a direct link between AMPK and the insulin signalling pathway; this pathway promotes energy conservation and survival of muscle exposed to severe glucose deprivation. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2407-yAuthors I. Chopra, Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, RMSB 6038, Miami, FL 33136, USAH. F. Li, Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, RMSB 6038, Miami, FL 33136, USAH. Wang, Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, 1600... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5560743 Fri, 30 Dec 2011 07:08:20 +0100 5560743 http://www.medworm.com/index.php?rid=5552785&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp0r473t232860779%2F Conclusions/interpretation  Taken together, these data indicate that hepatic leptin signalling and subdiaphragmatic vagal inputs are not required for leptin upregulation of plasma IGFBP-2 nor blood glucose lowering in ob/ob mice. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2426-8Authors J. Levi, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3F. K. Huynh, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3H. C. Denroche, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sci... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5552785 Tue, 27 Dec 2011 17:04:39 +0100 5552785 http://www.medworm.com/index.php?rid=5552786&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1682p1063005u388%2F Conclusions/interpretation  Oral treatment of 4 weeks duration with the dual endothelin receptor antagonist, bosentan, improves peripheral endothelial function in patients with type 2 diabetes and microalbuminuria. Trial Registration:  ClinicalTrial.gov NCT01357109; Karolinska Clinical Trial Registration Identifier CT20090017 (see www.kctr.se) Funding:  Research Council of Sweden, Swedish Heart and Lung Foundation, Novo Nordisk Foundation, Karolinska Institutet/Stockholm County Council Strategic Cardiovascular Programme, Gustav V and Queen Victoria Foundation, the Family Erling Persson Foundation, Actelion Pharmaceuticals and Actelion Research Award. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5552786 Mon, 26 Dec 2011 16:46:56 +0100 5552786 http://www.medworm.com/index.php?rid=5544847&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpw583823353161hg%2F Conclusions/interpretation  ApoAI and retinal arteriolar tortuosity made considerable contributions to DR risk, independently of traditional risk markers. Findings from this study suggest that serum ApoAI and retinal arteriolar tortuosity may be novel and independent risk markers of DR. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00125-011-2424-xAuthors M. B. Sasongko, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, 32 Gisborne Street, Melbourne, VIC 3002, AustraliaT. Y. Wong, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, 32 Gisborne Street, Melbourne, VIC 3002, AustraliaT. T. Nguyen, Centre for Eye Research Australia, Royal Victoria... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544847 Sat, 24 Dec 2011 06:42:02 +0100 5544847 http://www.medworm.com/index.php?rid=5544846&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F02568147141n5791%2F Conclusions/interpretation  Depression is common in primary care patients with type 2 diabetes, with one in seven patients reporting incident depression during a 2.5 year period. Once present, depression often becomes a chronic/recurrent condition in this group. In order to identify patients who are vulnerable to depression, clinicians can use questionnaire data and/or information about the history of depression. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2411-2Authors G. Nefs, Center of Research on Psychology in Somatic diseases (CoRPS), Department of Medical Psychology and Neuropsychology, Tilburg University, PO Box 90153, 5000 LE Tilburg, the NetherlandsF. Pouwer, Center of Research on Psychology in Somatic diseases (CoRPS), ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544846 Sat, 24 Dec 2011 06:42:02 +0100 5544846 http://www.medworm.com/index.php?rid=5544849&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F01n310v77tu6g706%2F Conclusions/interpretation  Our results demonstrate that the increased association of IAP with SHPS-1 contributes to the pathophysiological changes in the endothelium that are induced by hyperglycaemia and hypoxia. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2416-xAuthors L. A. Maile, Departments of Medicine and Ophthalmology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAK. Gollahon, Departments of Medicine and Ophthalmology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAC. Wai, Departments of Medicine and Ophthalmology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAG. Byfield, Departments of Medicine and Ophthalmology,... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544849 Fri, 23 Dec 2011 06:49:32 +0100 5544849 http://www.medworm.com/index.php?rid=5544848&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8802321k63841438%2F Conclusions/interpretation  Although IR is associated with increased arterial stiffness, traditional cardiovascular risk factors, especially obesity and BP, are the major determinants of arterial stiffness in healthy young people. Content Type Journal ArticleCategory ArticlePages 1-7DOI 10.1007/s00125-011-2412-1Authors E. M. Urbina, Department of Pediatrics, Preventive Cardiology, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, 3333 Burnet Avenue, MLC-7002, Cincinnati, OH 45229, USAZ. Gao, Department of Pediatrics, Preventive Cardiology, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, 3333 Burnet Avenue, MLC-7002, Cincinnati, OH 45229, USAP. R. Khoury, Department of Pediatrics, Preventive Cardiology, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544848 Fri, 23 Dec 2011 06:49:32 +0100 5544848 http://www.medworm.com/index.php?rid=5544850&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7262220810u65u2v%2F Conclusions/interpretation  We have shown that glycaemic burden and the presence of microvascular complications are associated with small fibre dysfunction in type 1 diabetes. Content Type Journal ArticleCategory ArticlePages 1-6DOI 10.1007/s00125-011-2417-9Authors P. R. J. Vas, The Diabetes Research Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich, Suffolk IP4 5PD, UKA. Q. Green, The Diabetes Research Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich, Suffolk IP4 5PD, UKG. Rayman, The Diabetes Research Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich, Suffolk IP4 5PD, UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544850 Fri, 23 Dec 2011 06:49:30 +0100 5544850 http://www.medworm.com/index.php?rid=5544851&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3530lp221w512x29%2F Abstract  Physical activity improves well-being and reduces the risk of heart disease, cancer and type 2 diabetes mellitus in the general population. In individuals with established type 2 diabetes, physical activity improves glucose and lipid levels, reduces weight and improves insulin resistance. In type 1 diabetes mellitus, however, the benefits of physical activity are less clear. There is poor evidence for a beneficial effect of physical activity on glycaemic control and microvascular complications, and significant risk of harm through hypoglycaemia. Here we review the literature relating to physical activity and health in type 1 diabetes. We examine its effect on a number of outcomes, including glycaemic control, lipids, blood pressure, diabetic complications, well-be... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544851 Thu, 22 Dec 2011 06:44:45 +0100 5544851 http://www.medworm.com/index.php?rid=5544852&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5h73543445461423%2F Conclusions/interpretation  Although contributing marginally to glucose-induced insulin secretion, compound exocytosis becomes quantitatively significant under conditions associated with global elevation of cytoplasmic calcium. These findings suggest that compound exocytosis is a major contributor to the augmentation of glucose-induced insulin secretion by muscarinic receptor activation. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2400-5Authors M. B. Hoppa, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ UKE. Jones, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ UKJ. Karanauskaite, Oxford Centre for Diabetes, Endocrinology and Metabolism, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544852 Wed, 21 Dec 2011 20:06:01 +0100 5544852 http://www.medworm.com/index.php?rid=5544853&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv83047k45k62u103%2F Conclusions/interpretation  Our review suggests a consistent reno-protective effect of ACEI/ARB over other antihypertensive drugs, mainly CCBs, and placebo in type 2 diabetes. The lack of any differences in BP decrease between ACEI/ARB and active comparators suggest this benefit is not due simply to the antihypertensive effect. Content Type Journal ArticleCategory Meta-analysisPages 1-13DOI 10.1007/s00125-011-2398-8Authors P. Vejakama, Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Rachatevi, Bangkok, 10400 ThailandA. Thakkinstian, Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Rachatevi, Bangkok, 10400 Th... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544853 Wed, 21 Dec 2011 20:06:00 +0100 5544853 http://www.medworm.com/index.php?rid=5544854&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe038w1t4811323w2%2F Conclusions/interpretation  In patients with type 2 diabetes, HbA1c levels were associated with lower risks of macrovascular events and death down to a threshold of 7.0% and microvascular events down to a threshold of 6.5%. There was no evidence of lower risks below these levels but neither was there clear evidence of harm. Trial Registration:  ClinicalTrial.gov NCT00145925 Funding:  Servier and the National Health and Medical Research Council of Australia (project grant ID 211086 and programme grant IDs 358395 and 571281) Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2404-1Authors S. Zoungas, The George Institute for Global Health, PO Box M201, Missenden Road, Camperdown, NSW 2050 Sydney, NSW, Austra... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5544854 Wed, 21 Dec 2011 19:46:30 +0100 5544854 http://www.medworm.com/index.php?rid=5515801&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff7532711h2114135%2F Conclusions/interpretation  The risk factor patterns for AD use are similar among type 1 diabetic patients and controls, and socioeconomic risk factors, rather than the diabetes per se, contribute to the increased risk of AD use in young adults with type 1 diabetes. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2405-0Authors T. Lind, Department of Clinical Sciences, Pediatrics, Umeå University, 901 87 Umeå, SwedenI. Waernbaum, Department of Statistics, Umeå University, Umeå, SwedenY. Berhan, Department of Clinical Sciences, Pediatrics, Umeå University, 901 87 Umeå, SwedenG. Dahlquist, Department of Clinical Sciences, Pediatrics, Umeå University, 901 87 Umeå, Sweden Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-18... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515801 Fri, 16 Dec 2011 17:29:02 +0100 5515801 http://www.medworm.com/index.php?rid=5515802&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6185q118v14244r2%2F Conclusions/interpretation  Overall, our findings show that the PPARβ/δ activator GW501516 prevents IL-6-induced STAT3 activation by inhibiting ERK1/2 phosphorylation and preventing the reduction in phospho-AMPK levels. These effects of GW501516 may contribute to the prevention of cytokine-induced insulin resistance in hepatic cells. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2401-4Authors L. Serrano-Marco, Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Institut de Biomedicina de la UB (IBUB), Diagonal 643, E-08028 Barcelona, SpainE. Barroso, Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, In... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515802 Fri, 16 Dec 2011 17:28:59 +0100 5515802 http://www.medworm.com/index.php?rid=5515803&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4819n3xv281q4h2%2F Conclusions/interpretation  Postprandial hyperinsulinaemia and modest hyperglycaemia overcome insulin resistance by enhancing tissue glucose uptake and intracellular glucose utilisation. Content Type Journal ArticleCategory ArticlePages 1-6DOI 10.1007/s00125-011-2413-0Authors J. E. Galgani, Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Clasificador 7, Santiago, ChileE. Ravussin, Pennington Biomedical Research Center, Baton Rouge, LA, USA Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515803 Thu, 15 Dec 2011 16:49:15 +0100 5515803 http://www.medworm.com/index.php?rid=5515804&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc21672360h53t116%2F Content Type Journal ArticleCategory Retraction NotePages 1-1DOI 10.1007/s00125-011-2394-zAuthors Y. Hattori, Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, JapanT. Jojima, Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, JapanA. Tomizawa, Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, JapanH. Satoh, Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, JapanS. Hattori, Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, JapanK. Kasai, Department of Endocrinology and Metabolism, Dokkyo University School of Med... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515804 Wed, 14 Dec 2011 16:41:26 +0100 5515804 http://www.medworm.com/index.php?rid=5515806&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft871w21451258x20%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00125-011-2389-9Authors M. Igoillo-Esteve, Laboratory of Experimental Medicine, Université Libre de Bruxelles, CP-618, Route de Lennik 808, 1070 Brussels, BelgiumL. Marselli, Department of Endocrinology and Metabolism, Metabolic Unit–University of Pisa, Pisa, ItalyD. A. Cunha, Laboratory of Experimental Medicine, Université Libre de Bruxelles, CP-618, Route de Lennik 808, 1070 Brussels, BelgiumL. Ladrière, Laboratory of Experimental Medicine, Université Libre de Bruxelles, CP-618, Route de Lennik 808, 1070 Brussels, BelgiumF. Ortis, Laboratory of Experimental Medicine, Université Libre de Bruxelles, CP-618, Route de Lennik 808, 1070 Brussels, BelgiumF. A. Grieco, Department of Internal Medicine, Endocrine and Meta... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515806 Wed, 14 Dec 2011 16:41:25 +0100 5515806 http://www.medworm.com/index.php?rid=5515805&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb527xmhm84128151%2F Conclusions/interpretation  Age at menarche seems to be inversely associated with prediabetes and diabetes independent of confounding factors including current BMI. Women at risk for diabetes might be identified by a history of young age at menarche. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2410-3Authors D. Stöckl, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg, GermanyA. Döring, Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyA. Peters, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstäd... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515805 Wed, 14 Dec 2011 16:41:25 +0100 5515805 http://www.medworm.com/index.php?rid=5515807&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2112631p5151h123%2F Conclusions/interpretation  Higher sedentary time is associated with a poorer metabolic profile in people with type 2 diabetes. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2408-xAuthors A. R. Cooper, Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, 8 Priory Road, Bristol, BS8 1TZ UKS. Sebire, Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, 8 Priory Road, Bristol, BS8 1TZ UKA. A. Montgomery, School of Social and Community Medicine, University of Bristol, Bristol, UKT. J. Peters, School of Social and Community Medicine, University of Bristol, Bristol, UKD. J. Sharp, School of Social and Community Medicine, University of Bristol, Bristo... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515807 Wed, 14 Dec 2011 06:56:57 +0100 5515807 http://www.medworm.com/index.php?rid=5515809&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F733354185xl5u282%2F Conclusions/interpretation  Our results suggest that human islets have a distinctive distribution and function of key regulators of the glucose-stimulated insulin secretion pathway, emphasising the urgent need to understand the processes that regulate human islet beta cell function. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2369-0Authors C. Dai, Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University, 7435 MRBIV, Nashville, TN 37232, USAM. Brissova, Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University, 7435 MRBIV, Nashville, TN 37232, USAY. Hang, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, T... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515809 Tue, 13 Dec 2011 17:05:12 +0100 5515809 http://www.medworm.com/index.php?rid=5515808&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpj75h53718426278%2F Conclusions/interpretation  We conclude that moderate overnight hyperinsulinaemia recruited microvasculature in the more sensitive participants, while higher levels of plasma insulin were needed for more insulin resistant participants. This suggests that microvascular responsiveness to insulin is one determinant of metabolic insulin sensitivity in type 1 diabetes. Trial registration:  ClinicalTrials.gov NCT00943787 Funding:  This study is supported by the NIH/NIDDKRO1 DK 51562 grant and the University of Virginia General Clinical Research Center M01 RR 000847 grant. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2402-3Authors A. Chan, Center for Diabetes Technology, University of Virginia, P.O. 400 888... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515808 Tue, 13 Dec 2011 17:05:12 +0100 5515808 http://www.medworm.com/index.php?rid=5515812&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F57680023x347x4n5%2F Conclusions/interpretation  Intravenous administration of BNP increases glucose initial distribution volume and lowers plasma glucose concentrations following a glucose load, without affecting beta cell function or insulin sensitivity. These data support the theory that BNP has no diabetogenic properties, but improves metabolic status in men, and suggest new questions regarding BNP-induced differences in glucose availability and signalling in various organs/tissues. Trial registration:   ClinicalTrials.gov: NCT01324739 Funding:   The study was funded by Jubilée Fonds of the Austrian National Bank (OeNB-Fonds). Content Type Journal ArticleCategory ArticlePages 1-6DOI 10.1007/s00125-011-2392-1Authors B. B. Heinisch, Department of Cli... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515812 Tue, 13 Dec 2011 06:55:49 +0100 5515812 http://www.medworm.com/index.php?rid=5515811&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd8627w120q5703x0%2F Conclusions/interpretation  Our findings point to a contribution of AUF1 to the deleterious effects of cytokines on beta cell functions and suggest a role for this RNA-binding protein in the early phases of type 1 diabetes. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2399-7Authors E. Roggli, Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, SwitzerlandS. Gattesco, Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, SwitzerlandA. Pautz, Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, GermanyR. Regazzi, Department of... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515811 Tue, 13 Dec 2011 06:55:49 +0100 5515811 http://www.medworm.com/index.php?rid=5515810&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd0226p60v8h46877%2F Conclusions/interpretation  Acute muscle insulin effects include enhanced ROS generation through xanthine oxidase. Additional NEFA elevation enhances mitochondrial ROS generation, activates IκB–NFκB and reduces insulin signalling. These alterations are not associated with acute reductions in mitochondrial enzyme activity and ATP production, and are reversed by antioxidant infusion. Thus, NEFA acutely cause systemic and muscle insulin resistance by enhancing muscle oxidative stress through mitochondrial ROS generation and IκB–NFκB activation. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2396-xAuthors R. Barazzoni, Clinica Medica, Department of Medical, Surgical and Health Sciences, University of Trieste, Ospedale Cattinara, St... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5515810 Tue, 13 Dec 2011 06:55:49 +0100 5515810 http://www.medworm.com/index.php?rid=5495206&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy2q65361x1783h92%2F Conclusions/interpretation  These studies identified a novel role for CEACAM2 in the regulation of metabolic rate and insulin sensitivity via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2388-xAuthors P. R. Patel, Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail Stop 1009, Toledo, OH 43614, USAS. K. Ramakrishnan, Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail Stop 1009, Toledo, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5495206 Sat, 10 Dec 2011 16:56:01 +0100 5495206 http://www.medworm.com/index.php?rid=5487648&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr55542m281704m20%2F Content Type Journal ArticleCategory CommentaryPages 1-3DOI 10.1007/s00125-011-2397-9Authors G. S. Korbutt, Department of Surgery, Alberta Diabetes Institute, Edmonton, AB, CanadaT. Y. Yeung, Department of Surgery, Alberta Diabetes Institute, Edmonton, AB, CanadaC. E. Ellis, Department of Surgery, Alberta Diabetes Institute, Edmonton, AB, Canada Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5487648 Tue, 06 Dec 2011 17:04:13 +0100 5487648 http://www.medworm.com/index.php?rid=5487649&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4r175454148r0643%2F Conclusions/interpretation  Detoxification of MG reduces AGE adduct accumulation, which, in turn, can prevent formation of key retinal neuroglial and vascular lesions as diabetes progresses. MG-derived AGEs play an important role in diabetic retinopathy. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2393-0Authors A. K. Berner, Centre for Vision and Vascular Science, Queen’s University Belfast, Royal Victoria Hospital, Belfast, BT12 6BA Northern Ireland, UKO. Brouwers, Department of Internal Medicine, Universiteit Maastricht, Maastricht, the NetherlandsR. Pringle, Centre for Vision and Vascular Science, Queen’s University Belfast, Royal Victoria Hospital, Belfast, BT12 6BA Northern Ireland, UKI. Klaassen, Department of Ophthalmology, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5487649 Mon, 05 Dec 2011 17:40:54 +0100 5487649 http://www.medworm.com/index.php?rid=5477052&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft64h32g223741q8k%2F Conclusions/interpretation  Colesevelam, a non-absorbed bile acid sequestrant, increased circulating incretins and improved tissue glucose metabolism in both the fasting and postprandial states in a manner different from other approved oral agents. Trial registration:  ClinicalTrials.gov NCT00596427 Funding:  The study was funded by Daiichi Sankyo. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2382-3Authors C. Beysen, Kinemed, Inc., 5980 Horton Street Suite 470, Emeryville, CA 94608, USAE. J. Murphy, Division of Endocrinology and Metabolism, University of California, San Francisco, CA, USAK. Deines, Kinemed, Inc., 5980 Horton Street Suite 470, Emeryville, CA 94608, USAM. Chan, Kinemed, Inc., 5980 Horton ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5477052 Fri, 02 Dec 2011 06:47:42 +0100 5477052 http://www.medworm.com/index.php?rid=5477053&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj86881p5gt007182%2F Conclusions/interpretation  Over three-quarters (78%) of retinopathy cases were found in persons without diabetes and a strong association between microalbuminuria and non-diabetic retinopathy was found. These results may have implications for patient management of the aged. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2395-yAuthors E. Gunnlaugsdottir, University Eye Department, Landspitalinn, 101 Reykjavik, IcelandS. Halldorsdottir, Icelandic Heart Association, Kopavogur, IcelandR. Klein, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USAG. Eiriksdottir, Icelandic Heart Association, Kopavogur, IcelandB. E. Klein, Department of Ophthalmology and Visual Sciences... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5477053 Fri, 02 Dec 2011 06:47:41 +0100 5477053 http://www.medworm.com/index.php?rid=5477054&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F12558x432247g522%2F Conclusions/interpretation  This study suggests that mast cells are involved in development of diabetic nephropathy. Through release of bioactive substances, such as tryptase, chymase, TGF-β1, renin and TNF-α, into the tubular interstitium by degranulation, mast cells could promote renal inflammation and fibrosis, and thus contribute to diabetic nephropathy. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2391-2Authors J. M. Zheng, Research Institute of Nephrology, Jingling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002 People’s Republic of ChinaG. H. Yao, Research Institute of Nephrology, Jingling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002 Peopl... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5477054 Thu, 01 Dec 2011 06:59:04 +0100 5477054 http://www.medworm.com/index.php?rid=5469472&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe1124783527g041h%2F Conclusions  These findings do not provide evidence of either beneficial or adverse effects of glucose-lowering agents on cancer risk and are consistent with changes in diabetes treatment in the few months prior to the diagnosis of cancer. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2390-3Authors T. P. van Staa, General Practice Research Database, Medicines and Healthcare products Regulatory Agency, Buckingham Palace Road, London, SW1W 9SZ UKD. Patel, General Practice Research Database, Medicines and Healthcare products Regulatory Agency, Buckingham Palace Road, London, SW1W 9SZ UKA. M. Gallagher, General Practice Research Database, Medicines and Healthcare products Regulatory Agency, Buckingham Palace Road, London, SW1W 9SZ UKM. L. de... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5469472 Wed, 30 Nov 2011 09:21:54 +0100 5469472 http://www.medworm.com/index.php?rid=5469473&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7712j8454n51q324%2F Conclusions/interpretation  Age-specific mortality is higher among people with diabetes, and rate ratios vary with age, sex, calendar period and cause of death. The distribution of causes of death was similar for persons with and without diabetes. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2383-2Authors M. B. Hansen, Steno Diabetes Center A/S, Niels Steensens Vej 2, DK-2820 Gentofte, DenmarkM. L. Jensen, Steno Diabetes Center A/S, Niels Steensens Vej 2, DK-2820 Gentofte, DenmarkB. Carstensen, Steno Diabetes Center A/S, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5469473 Wed, 30 Nov 2011 04:56:38 +0100 5469473 http://www.medworm.com/index.php?rid=5469475&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft60q16484kqg551m%2F Conclusions/interpretation  We showed that dSLs are significantly elevated in patients with type 2 diabetes mellitus and non-diabetic metabolic syndrome compared with healthy controls. They may, therefore, be useful novel biomarkers to improve risk prediction and therapy monitoring in these patients. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2384-1Authors A. Othman, Institute for Clinical Chemistry, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandM. F. Rütti, Institute for Clinical Chemistry, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandD. Ernst, Institute for Clinical Chemistry, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, SwitzerlandC. H. Saely, Vorarlberg Institute for... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5469475 Tue, 29 Nov 2011 22:23:16 +0100 5469475 http://www.medworm.com/index.php?rid=5469474&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb35p4341hl735064%2F Abstract  In this edition of ‘Then and now’ the initial studies by J.C. Pickup and colleagues supporting the hypothesis that type 2 diabetes is caused by activated innate immunity, published in Diabetologia in 1997 (40:1286–1292), are discussed. These initial findings led to research that has uncovered links between insulin resistance, obesity, circulating immune markers, immunogenetic susceptibility, macrophage function and chronic infection. Genetic variations leading to the altered production or function of circulating innate immune proteins, cellular pattern recognition receptors and inflammatory cytokines are linked to obesity, insulin resistance and type 2 diabetes. Components of the innate immune system in the muscle, bone, liver and adipose tissue, as well as m... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5469474 Tue, 29 Nov 2011 22:23:16 +0100 5469474 http://www.medworm.com/index.php?rid=5469476&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa451544286267820%2F Conclusions/interpretation  A single session of resistance- or endurance-type exercise substantially reduces the prevalence of hyperglycaemia during the subsequent 24 h period in individuals with IGT, and in insulin-treated and non-insulin-treated type 2 diabetic patients. Both resistance- and endurance-type exercise can be integrated in exercise intervention programmes designed to improve glycaemic control. Trial registration:  Clinicaltrials.gov NCT00945165 Funding:  The Netherlands Organization for Health Research and Development (ZonMw, the Netherlands). Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2380-5Authors J.-W. van Dijk, Department of Human Movement Sciences, NUTRIM School for Nutritio... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5469476 Tue, 29 Nov 2011 22:23:15 +0100 5469476 http://www.medworm.com/index.php?rid=5458410&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl32n77128860201g%2F Conclusions/interpretation  These results indicate that TCPTP deficiency in muscle has no effect on insulin signalling and glucose homeostasis, and does not prevent high-fat diet-induced insulin resistance. Thus, despite their high degree of sequence identity, PTP1B and TCPTP contribute differentially to insulin receptor regulation in muscle. Our results are consistent with the notion that these two highly related PTPs make distinct contributions to insulin receptor regulation in different tissues. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2386-zAuthors K. Loh, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, AustraliaT. L. Merry, Department of Biochemistry and Molecular Biology, Monash Univ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5458410 Mon, 28 Nov 2011 16:59:49 +0100 5458410 http://www.medworm.com/index.php?rid=5458411&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr76541174511q011%2F Conclusions  The observed duration effects suggest that both increased surveillance for cancer in the first years after diagnosis of diabetes, and reverse causation, where undiagnosed cancers increase the likelihood of diabetes diagnosis, play a role. For longer durations, a combination of common causes for diabetes and cancer, as well as the effects of diabetes and insulin exposure per se, may play a role in the association between diabetes and some cancers. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2381-4Authors B. Carstensen, Steno Diabetes Center, Niels Steensens Vej 2, 2829 Gentofte, DenmarkD. R. Witte, Department of Biostatistics, University of Copenhagen, Copenhagen, DenmarkS. Friis, Institute of Cancer Epidemiology, Danish ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5458411 Sat, 26 Nov 2011 16:48:35 +0100 5458411 http://www.medworm.com/index.php?rid=5458412&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq580612421090679%2F Conclusions/interpretation   INS GFP/w hESCs are a valuable tool for investigating the nature of early INS+ progenitors in beta cell ontogeny and will facilitate the development of novel protocols for generating INS+ cells from differentiating hESCs. Content Type Journal ArticleCategory ArticlePages 1-13DOI 10.1007/s00125-011-2379-yAuthors S. J. Micallef, Monash Immunology and Stem Cell Laboratories (MISCL), Level 3, Building 75, STRIP1, West Ring Road, Monash University, Clayton, Victoria 3800, AustraliaX. Li, Monash Immunology and Stem Cell Laboratories (MISCL), Level 3, Building 75, STRIP1, West Ring Road, Monash University, Clayton, Victoria 3800, AustraliaJ. V. Schiesser, Monash Immunology and Stem Cell Laboratories (MISCL), Level 3, Building 75, STRIP1, West... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5458412 Sat, 26 Nov 2011 06:42:04 +0100 5458412 http://www.medworm.com/index.php?rid=5449948&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk32k48u751u31023%2F Content Type Journal ArticleCategory Research LetterPages 1-3DOI 10.1007/s00125-011-2385-0Authors K. Hida, Steno Diabetes Center, Niels Steensens Vej1, 2820 Gentofte, DenmarkP. Poulsen, Novo Nordisk A/S, Soeborg, DenmarkS. Teshigawara, Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, JapanE. Nilsson, Steno Diabetes Center, Niels Steensens Vej1, 2820 Gentofte, DenmarkM. Friedrichsen, Steno Diabetes Center, Niels Steensens Vej1, 2820 Gentofte, DenmarkR. Ribel-Madsen, Steno Diabetes Center, Niels Steensens Vej1, 2820 Gentofte, DenmarkL. Grunnet, Steno Diabetes Center, Niels Steensens Vej1, 2820 Gentofte, DenmarkS. S. Lund, Steno Diabetes Center, Niels Steensens ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5449948 Thu, 24 Nov 2011 17:44:53 +0100 5449948 http://www.medworm.com/index.php?rid=5449949&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F688875p359t35w65%2F Conclusions/interpretation  The meta-analysis demonstrates that TCF7L2 rs7903146 polymorphism is a population-independent susceptibility locus for LADA in Europeans. The effect size is similar for LADA and type 2 diabetes. The gene effect on diabetes risk may be modulated by BMI, such that the lower the BMI, the higher the gene effect. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00125-011-2378-zAuthors K. Lukacs, 1st Department of Paediatrics, Semmelweis University, Bókay u 53-54, 1083 Budapest, HungaryN. Hosszufalusi, 3rd Department of Internal Medicine, Semmelweis University, Budapest, HungaryE. Dinya, Institute of Health Informatics, Semmelweis University, Budapest, HungaryM. Bakacs, Pharmaproject-Statistics Incorporation, Budape... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5449949 Tue, 22 Nov 2011 17:56:46 +0100 5449949 http://www.medworm.com/index.php?rid=5449950&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw2364w4664351657%2F Conclusions/interpretation   FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, FTO is also associated with type 2 diabetes independently of BMI. Content Type Journal ArticleCategory ArticlePages 1-15DOI 10.1007/s00125-011-2370-7Authors H. Li, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-Yuan Road, Shanghai, 200031 People’s Republic of ChinaT. O. Kilpeläinen, MRC Epidemiology Unit, Institute of Metabolic Science Box 285, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ UKC. Liu, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, C... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5449950 Tue, 22 Nov 2011 17:56:45 +0100 5449950 http://www.medworm.com/index.php?rid=5441598&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff72xn73l8m121644%2F Conclusions/interpretation  Lipid accumulation in the subsarcolemmal region is not necessary for insulin resistance. In the intermyofibrillar compartment, the diversion of lipids away from mitochondria in insulin-resistant animals probably contributes to lipid accumulation in this subcellular area. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2367-2Authors J. S. V. Lally, Department of Human Health and Nutritional Science, University of Guelph, Guelph, ON, Canada N1G 2W1L. A. Snook, Department of Human Health and Nutritional Science, University of Guelph, Guelph, ON, Canada N1G 2W1X. X. Han, Department of Human Health and Nutritional Science, University of Guelph, Guelph, ON, Canada N1G 2W1A. Chabowski, Department of Physiology, Medica... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5441598 Sat, 19 Nov 2011 06:51:37 +0100 5441598 http://www.medworm.com/index.php?rid=5441599&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6687h7rnqj78404p%2F Conclusions/interpretations  These are the first data investigating myometrium in diabetic patients and they support the hypothesis that there is poorer contractility even in the presence of oxytocin. The underlying mechanism is related to reduced Ca channel expression and intracellular calcium signals and a decrease in muscle mass. We conclude that these factors significantly contribute to the increased emergency CS rate in diabetic patients. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2371-6Authors S. Al-Qahtani, Department of Molecular and Cellular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool, L69 3BX UKA. Heath, Department of Molecular and Cellular Physiology, Institute of Tran... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5441599 Sat, 19 Nov 2011 06:51:35 +0100 5441599 http://www.medworm.com/index.php?rid=5432222&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc423265845tw4868%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00125-011-2375-2Authors M. N. Pham, Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Duesseldorf, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyM. I. Hawa, Blizard Institute of Cell and Molecular Science, London, UKC. Pfleger, Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Duesseldorf, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyM. Roden, Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Duesseldorf, Auf’m Hennekamp 65, 40225 Duesseldorf, GermanyG. Schernthaner, Department of Medicine ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5432222 Fri, 18 Nov 2011 06:54:51 +0100 5432222 http://www.medworm.com/index.php?rid=5432221&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1341377ml960p58%2F Conclusion  We show for the first time that renal and circulating NSA2/NSA2 levels are increased in hyperglycaemia in experimental models of diabetes, and that circulating NSA2 is elevated in DN patients with albuminuria. Further studies will be required to assess whether NSA2 plays a role in the pathogenesis of DN. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2373-4Authors R. Shahni, Diabetes Research Group, Division of Diabetes and Nutritional Sciences, School of Medicine, Kings College London, Hodgkin Building, London Bridge, London, SE1 1UL UKL. Gnudi, Cardiovascular Division, School of Medicine, Kings College London, London, UKA. King, Diabetes Research Group, Division of Diabetes and Nutritional Sciences, School of Medicine, Kings... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5432221 Fri, 18 Nov 2011 06:54:51 +0100 5432221 http://www.medworm.com/index.php?rid=5432224&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb6246j8788671x53%2F Conclusions/interpretation  Seroconversion to (persistent) Ab+ occurs regardless of age. Although the progression rate to diabetes is higher under age 10 years, later seroconverters (up to age 40 years) have similar characteristics when compared with age-matched initially Ab+ relatives and generate an important minority of prediabetic relatives, warranting their identification and, eventually, enrolment in prevention trials. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2376-1Authors I. Vermeulen, Diabetes Research Center, Brussels Free University, VUB, Laarbeeklaan 103, 1090 Brussels, BelgiumI. Weets, Diabetes Research Center, Brussels Free University, VUB, Laarbeeklaan 103, 1090 Brussels, BelgiumO. Costa, Department of Clinic... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5432224 Fri, 18 Nov 2011 06:54:50 +0100 5432224 http://www.medworm.com/index.php?rid=5432223&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkjw12652q833064v%2F Conclusions  We conclude that early insulin treatment protects Munich Ins2 C95S mutant mice from insulin resistance, alpha cell hyperfunction, beta cell loss and hyperplasia of non-beta cells, some well-known features of human diabetes mellitus. Therefore, insulin treatment may be considered early for human patients harbouring INS mutations. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2362-7Authors S. Kautz, Institute of Veterinary Pathology, Ludwig-Maximilians-Universität München, Veterinärstr. 13, 80539 Munich, GermanyL. van Bürck, Institute of Veterinary Pathology, Ludwig-Maximilians-Universität München, Veterinärstr. 13, 80539 Munich, GermanyM. Schuster, Institute of Veterinary Pathology, Ludwig-Maximilians-Universität Mü... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5432223 Fri, 18 Nov 2011 06:54:50 +0100 5432223 http://www.medworm.com/index.php?rid=5432225&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj8w433717687u14v%2F Conclusions/interpretation  We cannot rule out the possibility that common variants in or near OxPhos genes may influence beta cell function in non-diabetic individuals. However, our quantitative trait studies and a sufficiently large meta-analysis indicate that common variation in proximity to the examined OxPhos genes is not a major cause of insulin resistance or type 2 diabetes. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2377-0Authors L. S. Snogdal, Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Kløvervænget 6, 4th Floor, 5000 Odense, DenmarkM. Wod, Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Kløvervænget 6, 4th Floor, 5000 Odense, DenmarkN. Grarup, The ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5432225 Fri, 18 Nov 2011 06:54:48 +0100 5432225 http://www.medworm.com/index.php?rid=5432226&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa641n2844x813n24%2F Conclusions/interpretation  This study demonstrates a new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes. Content Type Journal ArticleCategory ArticlePages 1-13DOI 10.1007/s00125-011-2366-3Authors S.-L. Huang, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Shanghai, 201203 People’s Republic of ChinaR.-T. Yu, Northwest Plateau of Biology Institute, Chinese Academy of Sciences, 59 Xiguan Street, Xining, 810008 People’s Republic of ChinaJ. Gong, State Key Laboratory of Drug Research... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5432226 Fri, 18 Nov 2011 06:54:47 +0100 5432226 http://www.medworm.com/index.php?rid=5422719&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd250876r43335gu4%2F Conclusions/interpretation  Our results clearly demonstrate that kidney-targeting Smad7 gene transfer may be an effective therapy for type 2 diabetic nephropathy, acting via simultaneous modulation of the TGF-β/SMAD and NF-κB signalling pathways. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2364-5Authors S. M. Ka, Graduate Institute of Aerospace and Undersea Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of ChinaY. C. Yeh, Graduate Institute of Life Sciences, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of ChinaX. R. Huang, Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, H... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5422719 Tue, 15 Nov 2011 16:49:07 +0100 5422719 http://www.medworm.com/index.php?rid=5409156&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa1pw221q0246h407%2F Conclusions/interpretation  Physical activity is associated with lower all-cause and CVD mortality risk for individuals across all levels of glycaemic control. Therefore, engaging in a physically active lifestyle and achieving normal levels of glycaemic control may both be important for the prevention of early mortality. Content Type Journal ArticleCategory Short CommunicationPages 1-4DOI 10.1007/s00125-011-2374-3Authors J. I. Reddigan, School of Kinesiology and Health Science, 2002 Sherman Health Science Centre, York University, 4700 Keele Street, Toronto, ON, Canada M3J 1P3M. C. Riddell, School of Kinesiology and Health Science, York University, Norman Bethune College, Toronto, ON, CanadaJ. L. Kuk, School of Kinesiology and Health Science, 2002 Sherman Health Scien... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5409156 Sun, 13 Nov 2011 06:48:47 +0100 5409156 http://www.medworm.com/index.php?rid=5409157&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6847703h6g421qt%2F Conclusions/interpretation  Postprandial glucose control is impaired by significantly slower glucose disposal in late gestation. Early prandial insulin dosing may help to accelerate glucose disposal and potentially ameliorate postprandial hyperglycaemia in late pregnancy. Trial registration: ISRCTN 62568875 Funding: Diabetes UK Project Grant BDA 07/003551. H.R. Murphy is funded by a National Institute for Health Research (NIHR) research fellowship (PDF/08/01/036). Supported also by the Juvenile Diabetes Research Foundation (JDRF), Abbott Diabetes Care (Freestyle Navigator CGM and sensors free of charge), Medical Research Council Centre for Obesity and Related Metabolic Diseases and NIHR Cambridge Biomedical Research Centre. Content Type Journal Arti... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5409157 Sat, 12 Nov 2011 06:47:48 +0100 5409157 http://www.medworm.com/index.php?rid=5409158&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32u6182850025090%2F Abstract  A coordinated response by the innate immune system, (micro)circulation and nervous system is needed to limit tissue destruction and to initiate reparative processes after tissue damage. Alterations in danger signals in diabetes can be an important cause of the excessive tissue loss and defective tissue repair after injury and can contribute to the higher rates of cardiac failure after myocardial infarction, more severe tissue loss in the case of peripheral ischaemia and impaired wound healing. Here we discuss the mechanisms underlying this impaired damage control in diabetes, with an emphasis on the proinflammatory cytokine high mobility group box 1 and the potential role of dipeptidyl peptidase IV inhibition in improving repair responses. Content Type Journal... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5409158 Fri, 11 Nov 2011 16:45:05 +0100 5409158 http://www.medworm.com/index.php?rid=5409160&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn1j80tv730411037%2F Conclusions/interpretation  INS:GFP+ cells can be purified from differentiated hESCs, providing a superior source of insulin-producing cells. Genomic analyses revealed that INS:GFP+ cells collectively resemble immature endocrine cells. However, insulin+ cells were heterogeneous, a fact that translated into important functional differences within this population. The information gained from this study may now be used to generate new iterations of functioning beta cells that can be purified for transplant. Content Type Journal ArticleCategory ArticlePages 1-14DOI 10.1007/s00125-011-2335-xAuthors C. L. Basford, Division of Cellular and Molecular Biology, Toronto General Research Institute, TMDT, Toronto, ON, CanadaK. J. Prentice, Division of Cellular and Molecular Biolo... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5409160 Thu, 10 Nov 2011 16:50:14 +0100 5409160 http://www.medworm.com/index.php?rid=5409159&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx538373x50264978%2F Conclusions/interpretation  These results suggest that autophagy is important for intact UPR machinery and appropriate UPR in response to lipid injury that increases demand for UPR. Autophagy deficiency in pancreatic beta cells may contribute to the progression from obesity to diabetes. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2350-yAuthors W. Quan, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-ku, Seoul, 135-710 South KoreaK. Y. Hur, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-ku, Seoul, 135-710 South KoreaY. Lim, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School o... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5409159 Thu, 10 Nov 2011 16:50:14 +0100 5409159 http://www.medworm.com/index.php?rid=5409162&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F62m0618226857k51%2F Content Type Journal ArticleCategory Research LetterPages 1-3DOI 10.1007/s00125-011-2351-xAuthors Z. Panossian, Auckland Diabetes Centre, Greenlane Clinical Centre, PO Box 92189, Auckland, 1142 New ZealandP. L. Drury, Auckland Diabetes Centre, Greenlane Clinical Centre, PO Box 92189, Auckland, 1142 New ZealandT. Cundy, Auckland Diabetes Centre, Greenlane Clinical Centre, PO Box 92189, Auckland, 1142 New Zealand Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5409162 Thu, 10 Nov 2011 06:45:25 +0100 5409162 http://www.medworm.com/index.php?rid=5409161&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Feumv30605350vw48%2F Conclusions/interpretation  Our results suggest that the ability of DPP-4 inhibition to suppress the progression to STZ-induced hyperglycaemia involves both alleviation of beta cell death and alpha cell proliferation. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2365-4Authors Y. Takeda, Division of Metabolism and Biosystemic Science, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510 JapanY. Fujita, Division of Metabolism and Biosystemic Science, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510 JapanJ. Honjo, Division of Metabolism and Biosystemic Science, Department of Internal Medicine, Asahikawa Medical Universit... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5409161 Thu, 10 Nov 2011 06:45:25 +0100 5409161 http://www.medworm.com/index.php?rid=5388082&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl172xj644433m477%2F Conclusions/interpretation  A cluster of metabolites comprising BCAAs and related analytes predicts improvement in HOMA-IR independent of the amount of weight lost. These results may help identify individuals most likely to benefit from moderate weight loss and elucidate novel mechanisms of IR in obesity. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2356-5Authors S. H. Shah, Department of Medicine, DUMC, Duke University Medical Center, Box 3445, Durham, NC 27710, USAD. R. Crosslin, Department of Biostatistics, University of Washington, Seattle, WA, USAC. S. Haynes, Center for Human Genetics, Duke University Medical Center, Durham, NC, USAS. Nelson, Department of Biostatistics, University of Washington, Seattle, WA, USAC. B. Turer, Depa... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5388082 Mon, 07 Nov 2011 16:59:57 +0100 5388082 http://www.medworm.com/index.php?rid=5388083&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4711p181g7v770ju%2F Conclusions/interpretation  The median time to resolution was longer than in earlier series. Although limited by being observational and non-randomised, these data suggest that the use of non-removable off-loading at presentation may shorten the time to resolution. They provide no evidence to indicate that the use of bisphosphonates is beneficial. Content Type Journal ArticleCategory Short CommunicationPages 1-4DOI 10.1007/s00125-011-2354-7Authors F. L. Game, Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, Nottingham University Hospitals Trust, City Hospital Campus, Hucknall Road, Nottingham, NG5 1PB UKR. Catlow, East Lancashire Healthcare Trust, Blackburn, UKG. R. Jones, East Lancashire Healthcare Trust, Blackburn, UKM. E. Edmonds, Kings College Ho... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5388083 Mon, 07 Nov 2011 16:59:56 +0100 5388083 http://www.medworm.com/index.php?rid=5388084&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp40232r8tn665u70%2F Conclusions/interpretation  TV viewing habits in early adulthood are associated with adverse cardiometabolic profiles in early middle adulthood that are independent of TV viewing habits and physical activity in middle age, but not independent of BMI in early adulthood. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2358-3Authors E. Stamatakis, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT UKM. Hamer, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT UKG. D. Mishra, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT UK Journal DiabetologiaOnlin... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5388084 Sat, 05 Nov 2011 17:09:31 +0100 5388084 http://www.medworm.com/index.php?rid=5388085&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx02r412v6r674361%2F Conclusions/interpretation  Depression is associated with a persistent twofold increased risk of mortality in people with their first DFU at 5 years. Content Type Journal ArticleCategory ArticlePages 1-8DOI 10.1007/s00125-011-2359-2Authors K. Winkley, Department of Psychological Medicine, King’s College London & Institute of Psychiatry, Weston Education Centre, 10 Cutcombe Road, London, SE5 8AZ UKH. Sallis, Department of Biostatistics, King’s College London & Institute of Psychiatry, De Crespigny Park, London, UKD. Kariyawasam, Guy’s and St Thomas’ NHS Foundation Trust, London, UKL. H. Leelarathna, Guy’s and St Thomas’ NHS Foundation Trust, London, UKT. Chalder, Department of Psychological Medicine, King’s College London & Institute of Psychiatry, West... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5388085 Sat, 05 Nov 2011 17:09:30 +0100 5388085 http://www.medworm.com/index.php?rid=5388086&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnk42713616j20v00%2F Abstract  Periodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly prevalent (severe periodontitis affects 10–15% of adults) and has multiple negative impacts on quality of life. Epidemiological data confirm that diabetes is a major risk factor for periodontitis; susceptibility to periodontitis is increased by approximately threefold in people with diabetes. There is a clear relationship between degree of hyperglycaemia and severity of periodontitis. The mechanisms that underpin the links between these two conditions are not completely understood, but involve aspects of immune functioning, neutrophil activity, and cytokine biology. There is emerg... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5388086 Sat, 05 Nov 2011 17:09:29 +0100 5388086 http://www.medworm.com/index.php?rid=5388087&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F63r5453j067t450j%2F Abstract  The obesity epidemic is an overwhelming global health concern. Interventions to improve body weight and composition aim to restore balance between nutrient intake and energy expenditure. Myostatin, a powerful negative regulator of skeletal muscle mass, has emerged as a potential therapeutic target for obesity and type 2 diabetes mellitus because of the prominent role skeletal muscle plays in metabolic rate and insulin-mediated glucose disposal. In fact, inhibition of myostatin by genetic manipulation or pharmacological means leads to a hypermuscular and very lean build in mice. The resistance of myostatin-null mice to diet-induced obesity, fat mass accumulation and metabolic dysfunction has been presumed to be a result of their large skeletal muscle mass; however,... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5388087 Sat, 05 Nov 2011 17:09:28 +0100 5388087 http://www.medworm.com/index.php?rid=5388088&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F62m8822j11u7575g%2F Conclusions/interpretation  We validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2355-6Authors V. Gupta, South Asia Network for Chronic Disease, Public Health Foundation of India, C-1/52, Safdarjung Development Area, New Delhi, 110016 IndiaD. G. Vinay, Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Habshiguda, Uppal Road, Hyderabad, 500007 IndiaS. Rafiq, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UKM. V. Kranthikumar, Centre for Cellular and Molecu... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5388088 Thu, 03 Nov 2011 16:56:40 +0100 5388088 http://www.medworm.com/index.php?rid=5361473&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc0812t1271g76780%2F Conclusions/interpretation  Uncertainty persists regarding the clinically relevant risks and benefits of TZDs and vitamin D because of the early cancellation of this comprehensive trial. Trial registration:  ClinicalTrials.gov NCT00879970 Funding:  The study was funded by GlaxoSmithKline. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2357-4Authors The TIDE Trial Investigators, c/o Z. Punthakee, Population Health Research Institute, McMaster University, 237 Barton St E., Hamilton, ON, Canada L8L 2X2 Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361473 Sat, 29 Oct 2011 05:43:28 +0100 5361473 http://www.medworm.com/index.php?rid=5361474&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd39254468m500628%2F Conclusions/interpretation  Our results indicate that cells co-producing insulin and glucagon in the developing human pancreas share a transcription factor profile that is similar to that of mature alpha cells and suggest that some maturing alpha cells briefly exhibit ectopic insulin expression. Thus cells that co-produce insulin and glucagon may represent a transient cell population, which gives rise to mature alpha cells. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2344-9Authors M. J. Riedel, Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z3A. Asadi, Laboratory of Molecula... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361474 Fri, 28 Oct 2011 16:46:03 +0100 5361474 http://www.medworm.com/index.php?rid=5361476&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl5706250447805u3%2F Conclusions/interpretation  Our study has yielded substantial new insight into low eGFR and provided a collection of potential urinary biomarkers for its detection. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2339-6Authors D. P. K. Ng, Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive MD3, Singapore, 117597 Republic of SingaporeA. Salim, Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive MD3, Singapore, 117597 Republic of SingaporeY. Liu, Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive MD3, Singapor... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361476 Fri, 28 Oct 2011 16:46:02 +0100 5361476 http://www.medworm.com/index.php?rid=5361475&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv737h1378v5nvrq5%2F Conclusions/interpretation  Through its action on the β-subunit of ecto-F1Fo complex, which results in intracellular acidosis, CF6 plays a crucial role in the development of insulin resistance and hypertension. This finding might advance our understanding of the mechanisms underlying diabetes and hypertension, possibly also providing a novel therapeutic target against cardiovascular disease. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2341-zAuthors T. Osanai, Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562 JapanM. Tanaka, Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562 JapanK. Magota, Asubio Pharma, Faculty of Discove... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361475 Fri, 28 Oct 2011 16:46:02 +0100 5361475 http://www.medworm.com/index.php?rid=5361477&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu325112606447578%2F Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s00125-011-2349-4Authors J. R. Zierath, Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, von Eulers väg 4, 4th Floor, 171 77 Stockholm, Sweden Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361477 Fri, 28 Oct 2011 16:45:58 +0100 5361477 http://www.medworm.com/index.php?rid=5361479&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3t1g0547681mv716%2F Conclusions/interpretation  Islet amyloid formation induces JNK activation, which upregulates predominantly pro-apoptotic signals in both extrinsic and intrinsic pathways, resulting in beta cell apoptosis. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2338-7Authors S. L. Subramanian, Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, WA 98108, USAR. L. Hull, Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, WA 98108, USAS. Zraika, Division of Metabolism, Endocrinology, and Nutrition, Depart... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361479 Fri, 28 Oct 2011 16:45:56 +0100 5361479 http://www.medworm.com/index.php?rid=5361478&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb2445545415m6101%2F Conclusions/interpretation  Together, these data suggest that UCHL1 has essential functional and anti-apoptotic roles in beta cells under stress conditions associated with lipotoxicity. Content Type Journal ArticleCategory ArticlePages 1-13DOI 10.1007/s00125-011-2323-1Authors K. Y. Chu, Laboratory of Molecular Signaling in Diabetes, Diabetes Research Group, Department of Cellular and Physiological Sciences, University of British Columbia, 5358 Life Sciences Building, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3H. Li, Laboratory of Molecular Signaling in Diabetes, Diabetes Research Group, Department of Cellular and Physiological Sciences, University of British Columbia, 5358 Life Sciences Building, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3K. ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361478 Fri, 28 Oct 2011 16:45:56 +0100 5361478 http://www.medworm.com/index.php?rid=5361480&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fat07554l12382w08%2F Conclusions/interpretation  Common genetic risk variants at GCK, SLC30A8, IGF2BP2 and MTNR1B influence to different extents the development of IFG and the transition from IFG to type 2 diabetes. Our findings may have implications for understanding the genetic contribution of these variants to the development of IFG and type 2 diabetes. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2353-8Authors G. A. Walford, Center for Human Genetic Research, Simches Research Building—CPZN 5.250, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USAT. Green, Center for Human Genetic Research, Simches Research Building—CPZN 5.250, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USAB. Neale, Center for Huma... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361480 Fri, 28 Oct 2011 16:45:51 +0100 5361480 http://www.medworm.com/index.php?rid=5361481&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F236165155l45r84r%2F Content Type Journal ArticleCategory CommentaryPages 1-3DOI 10.1007/s00125-011-2360-9Authors M. Kivimäki, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT London, UKG. D. Batty, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT London, UK Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia) Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361481 Fri, 28 Oct 2011 16:45:50 +0100 5361481 http://www.medworm.com/index.php?rid=5361482&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F91654760467r6871%2F Conclusions/interpretation  Our study suggests the common human P446L-GKRP variant protein results in elevated hepatic glucose uptake and disposal by increasing active cytosolic GCK. This would increase hepatic lipid biosynthesis but decrease fasting plasma glucose concentrations and provides a potential mechanism for the protective effect of this allele on type 2 diabetes risk. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2348-5Authors M. G. Rees, Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, OX3 7LJ UKS. Wincovitch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USAJ. Schultz, Institute for Medical Biochemistry & Molecular Bi... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361482 Fri, 28 Oct 2011 16:45:44 +0100 5361482 http://www.medworm.com/index.php?rid=5361483&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl3878j174q8h101t%2F Abstract  A number of observational studies have linked insulin glargine (A21Gly,B31Arg,B32Arg human insulin) with a putative increased cancer risk, particularly breast cancer, but many of these ‘first generation’ studies had study design and analysis flaws, and were inconclusive. A small number of ‘second generation’ studies are now emerging in which the applied pharmaco-epidemiological principles are more robust. For example, when Ruitar and colleagues (Diabetologia DOI:10.1007/s00125-011-2312-4) focused specifically on breast cancer rather than all incident cancer risk, they were able to show a positive association with insulin glargine for breast cancer although there was no association with all incident cancer risk. A list of preferred qualities for pharmaco-epi... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361483 Fri, 28 Oct 2011 06:04:15 +0100 5361483 http://www.medworm.com/index.php?rid=5361484&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu7858x67571m8166%2F Conclusions/interpretation  In a population of patients with type 1 diabetes, purchase of antidepressant agents was associated with increased mortality rates in women, but not in men. Content Type Journal ArticleCategory ArticlePages 1-7DOI 10.1007/s00125-011-2347-6Authors A. J. Ahola, Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, FinlandV. Harjutsalo, Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, FinlandM. Saraheimo, Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, FinlandC. Forsblom, Folkhälsan Institut... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5361484 Fri, 28 Oct 2011 06:04:13 +0100 5361484 http://www.medworm.com/index.php?rid=5348401&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8xj3246520231l54%2F Conclusions/interpretations  Racial/ethnic disparities exist in risk of diabetes after GDM. Black women with GDM had the highest risk of developing diabetes. This highlights the importance of developing an effective diabetes screening and prevention programme in women with GDM, particularly black women with GDM. Content Type Journal ArticleCategory ArticlePages 1-6DOI 10.1007/s00125-011-2330-2Authors A. H. Xiang, Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles, 5th Floor, Pasadena, CA 91101, USAB. H. Li, Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles, 5th Floor, Pasadena, CA 91101, USAM. H. Black, Department of Research & Evaluation, Kaiser Permanente Southern California, 100... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5348401 Thu, 20 Oct 2011 15:52:21 +0100 5348401 http://www.medworm.com/index.php?rid=5348402&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff7800361511w44u3%2F Conclusions/interpretation  The WNT pathway is activated in the kidneys of models of both type 1 and 2 diabetes. Dysregulation of the WNT pathway in diabetes represents a new pathogenic mechanism of diabetic nephropathy and renders a new therapeutic target. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-011-2314-2Authors T. Zhou, Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaX. He, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAR. Cheng, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAB. Zhang, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma Ci... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5348402 Thu, 20 Oct 2011 15:52:19 +0100 5348402 http://www.medworm.com/index.php?rid=5336740&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx4055n886835344k%2F Conclusion  This is the first report of the impact of carrageenan on glucose tolerance and indicates that carrageenan impairs glucose tolerance, increases insulin resistance and inhibits insulin signalling in vivo in mouse liver and human HepG2 cells. These effects may result from carrageenan-induced inflammation. The results demonstrate extra-colonic manifestations of ingested carrageenan and suggest that carrageenan in the human diet may contribute to the development of diabetes. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2333-zAuthors S. Bhattacharyya, Department of Medicine, University of Illinois at Chicago, 840 South Wood Street, CSN 440, M/C 718, Chicago, IL 60612, USAI. O-Sullivan, Jesse Brown VA Medical Center, Chicago, IL,... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5336740 Wed, 19 Oct 2011 15:46:42 +0100 5336740 http://www.medworm.com/index.php?rid=5336741&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyhr2575u01g7865t%2F Conclusions/interpretation  Metformin treatment does not inhibit mitochondrial complex I respiration in the electron transport chain in human skeletal muscle of patients with type 2 diabetes when measured ex vivo. Inhibition of complex I and II respiration in controls was demonstrated by metformin titration in vitro at doses well above those observed during metformin treatment. Content Type Journal ArticleCategory ArticlePages 1-7DOI 10.1007/s00125-011-2340-0Authors S. Larsen, Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, DenmarkR. Rabøl, Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5336741 Wed, 19 Oct 2011 05:56:51 +0100 5336741 http://www.medworm.com/index.php?rid=5336742&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F621530w5t4001145%2F Content Type Journal ArticleCategory ErratumPages 1-2DOI 10.1007/s00125-011-2337-8Authors S. Z. Duan, Department of Internal Medicine, Nephrology Division, University of Michigan Medical School, Ann Arbor, MI, USAM. G. Usher, Department of Molecular and Integrative Physiology, University of Michigan Medical School, 7641 Med. Sci. II, 1150W. Med. Ctr. Dr, Ann Arbor, MI 48109-5622, USAE. L. Foley, Department of Molecular and Integrative Physiology, University of Michigan Medical School, 7641 Med. Sci. II, 1150W. Med. Ctr. Dr, Ann Arbor, MI 48109-5622, USAD. S. Milstone, Vascular Research Division, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAF. C. Brosius, Department of Internal Medicine, Nephrology Division, University of Michigan Medic... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5336742 Tue, 18 Oct 2011 15:58:31 +0100 5336742 http://www.medworm.com/index.php?rid=5336743&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd171uh45317p2h5m%2F Conclusions/interpretation  Glucotoxic ER stress dedifferentiates beta cells, in the absence of apoptosis, through a transcriptional response. These effects are mediated by the activation of ERK1/2. Content Type Journal ArticleCategory ArticlePages 1-13DOI 10.1007/s00125-011-2315-1Authors A. Lombardi, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Università degli Studi del Salento, 73100 Lecce, ItalyL. Ulianich, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli Federico II, Naples, ItalyA. S. Treglia, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Università degli Studi del Salento, 73100 Lecce, ItalyC. Nigro, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Stu... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5336743 Tue, 18 Oct 2011 05:49:00 +0100 5336743 http://www.medworm.com/index.php?rid=5336744&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5456104m646k6g50%2F Conclusions/interpretation  These data show that insulin resistance induced by palmitate is not related to ER stress in muscle cells. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2328-9Authors R. Hage Hassan, Inserm, UMR-S 872, Centre de Recherche des Cordeliers, Paris, 75006 FranceI. Hainault, Inserm, UMR-S 872, Centre de Recherche des Cordeliers, Paris, 75006 FranceJ.-T. Vilquin, Université Pierre et Marie Curie, Groupe Hospitalier Pitié-Salpêtrière, Paris, FranceC. Samama, Inserm, UMR-S 872, Centre de Recherche des Cordeliers, Paris, 75006 FranceF. Lasnier, Inserm, UMR-S 872, Centre de Recherche des Cordeliers, Paris, 75006 FranceP. Ferré, Inserm, UMR-S 872, Centre de Recherche des Cordeliers, Paris, 75006 FranceF. Foufelle, Inserm... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5336744 Tue, 18 Oct 2011 05:48:59 +0100 5336744 http://www.medworm.com/index.php?rid=5324417&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0123k82p17581402%2F Conclusions/interpretation  Insulin detemir induces significant and sustained weight loss, which is first observed at 1 week after changing from NPH insulin. The initial weight loss seems to be related to changes in fluid volume and may reflect changed insulin action in the kidneys. Trial registration:  EudraCT 2008-001602-16; ClinicalTrials.gov NCT00742976 Funding:  The study was funded by a Libra Grant from NovoNordisk, DK. Content Type Journal ArticleCategory ArticlePages 1-5DOI 10.1007/s00125-011-2345-8Authors K. V. Hendriksen, Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkT. Jensen, Department of Endocrinology, Rigshospitalet, Blegdamsvej 9, DK-2100 København Ø, DenmarkP. Oturai, De... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5324417 Sat, 15 Oct 2011 15:47:11 +0100 5324417 http://www.medworm.com/index.php?rid=5324418&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F73n8p612503158j0%2F Conclusions/interpretation  These results indicate that insulin's trans-endothelial movement within muscle is a saturable process, which is likely to involve the insulin receptor. Current findings, together with other recent reports, suggest that trans-endothelial insulin transport may be an important site at which muscle insulin action is modulated in clinical and pathological settings. Content Type Journal ArticleCategory ArticlePages 1-7DOI 10.1007/s00125-011-2343-xAuthors S. Majumdar, University of Virginia Health System, PO Box 801410, 450 Ray C. Hunt Drive, Charlottesville, VA 22908, USAA. J. Genders, University of Virginia Health System, PO Box 801410, 450 Ray C. Hunt Drive, Charlottesville, VA 22908, USAA. C. Inyard, University of Virginia Health System, PO B... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5324418 Sat, 15 Oct 2011 05:53:56 +0100 5324418 http://www.medworm.com/index.php?rid=5324419&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn325000036186121%2F Abstract  The prevalence and severity of obesity have increased to epidemic proportions around the globe, and over two-thirds of the US population grapples with either being overweight or obese. Obesity and its comorbidities not only subtract from quality of overall life, but also claim a substantial cost to life. In this edition of ‘Then and now’, two seminal papers by D.L. Coleman, ‘The influence of genetic background on the expression of the obese (ob) gene in the mouse’ and ‘Effects of parabiosis of obese with diabetes and normal mice’, which featured in Diabetologia in 1973, are appraised for their merit and foresight regarding the present eruption of research into what has consequently been labelled ‘the metabolic syndrome’. These two studies determined ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5324419 Sat, 15 Oct 2011 05:53:55 +0100 5324419 http://www.medworm.com/index.php?rid=5324420&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwvn0q30684360010%2F Conclusions/interpretation  Higher RDW values are associated with increased odds of developing cardiovascular disease and nephropathy in a nationally representative sample of USA adults with diabetes. RDW may be an important clinical marker of vascular complications in diabetes and one that is independent of traditional risk factors and disease duration. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2331-1Authors N. Malandrino, Division of Endocrinology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USAW. C. Wu, Center on Systems, Outcomes and Quality in Chronic Disease and Rehabilitation, Research Enhancement Award Program, Providence Veterans Affairs Medical Center, Providence, RI, USAT. H. ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5324420 Sat, 15 Oct 2011 05:53:54 +0100 5324420 http://www.medworm.com/index.php?rid=5324421&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm8l63l37654k1432%2F Conclusions/interpretation  Our results suggest a novel cholesterolgenic-based mechanism of FA-induced membrane/cytoskeletal disorder and insulin resistance. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2334-yAuthors K. M. Habegger, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, VanNuys Medical Science Building Rm 308A, 635 Barnhill Drive, Indianapolis, IN 46202-5120, USAB. A. Penque, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, VanNuys Medical Science Building Rm 308A, 635 Barnhill Drive, Indianapolis, IN 46202-5120, USAW. Sealls, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, VanNuys Medical Science Building ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5324421 Sat, 15 Oct 2011 05:53:53 +0100 5324421 http://www.medworm.com/index.php?rid=5324422&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq72l60264w8288v8%2F Conclusions/interpretation  Our data suggest that leptin and amylin have overlapping and additive, but not synergistic, effects in the activation of intracellular signalling pathways. ER stress may induce leptin and amylin resistance in hypothalamic, muscle and liver cell lines. These novel insights into the mode of action of leptin and amylin suggest that these hormones may play an additive role in regulating energy homeostasis in humans. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2332-0Authors H.-S. Moon, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USAJ. P. Chamberland, Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medic... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5324422 Fri, 14 Oct 2011 05:50:28 +0100 5324422 http://www.medworm.com/index.php?rid=5324423&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff1q664784p752785%2F Conclusions/interpretation  Stimulation of AMPK in embryos during a diabetic pregnancy mediates the effects of hyperglycaemia-induced oxidative stress to disturb the expression of the critical Pax3 gene, thereby causing NTDs. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2326-yAuthors Y. Wu, Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USAM. Viana, Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USAS. Thirumangalathu, Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USAM. R. Loeken, Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One J... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5324423 Thu, 13 Oct 2011 05:44:44 +0100 5324423 http://www.medworm.com/index.php?rid=5315189&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd1122512m964k072%2F Conclusions/interpretation  Olmesartan was well tolerated but did not improve renal outcome on top of ACEI. Trial registration: ClinicalTrials.gov NCT00141453 Funding: The ORIENT study was supported by a research grant from Daiichi Sankyo. Content Type Journal ArticleCategory ArticlePages 1-9DOI 10.1007/s00125-011-2325-zAuthors E. Imai, Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, JapanJ. C. N. Chan, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, SAR, ChinaS. Ito, Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Clinical Medicine, Tohoku University Gradu... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5315189 Wed, 12 Oct 2011 16:32:23 +0100 5315189 http://www.medworm.com/index.php?rid=5315190&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5mp7wu61j4l02h62%2F Conclusions/interpretation   ABCC8 mutations can cause MODY in patients whose clinical features are similar to those with HNF1A/4A MODY. Therefore, sequencing of ABCC8 in addition to the known MODY genes should be considered if such features are present, to facilitate optimal clinical management of these patients. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00125-011-2319-xAuthors P. Bowman, Peninsula NIHR Clinical Research Facility, Peninsula Medical School, University of Exeter, Exeter, UKS. E. Flanagan, Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter, UKE. L. Edghill, Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter, UKA. Damhu... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5315190 Wed, 12 Oct 2011 05:50:29 +0100 5315190 http://www.medworm.com/index.php?rid=5315191&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F41p8363308768051%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00125-011-2321-3Authors F. Fiory, Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale, del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Naples, ItalyA. Lombardi, Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale, del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Naples, ItalyC. Miele, Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale, del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Naples, ItalyJ. Giudicelli, Inse... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5315191 Wed, 12 Oct 2011 05:50:27 +0100 5315191 http://www.medworm.com/index.php?rid=5315192&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F353gg8787763w26j%2F Conclusions/interpretation  Chronic CB1 antagonism markedly enhances insulin-mediated glucose utilisation in DIO mice, independent of its anorectic and weight-reducing effects. The potent effect on insulin-stimulated BAT glucose uptake reveals a novel role for CB1 receptors as regulators of glucose metabolism. Content Type Journal ArticleCategory ArticlePages 1-11DOI 10.1007/s00125-011-2302-6Authors M. Bajzer, Metabolic Diseases Institute, University of Cincinnati, 2140 East Galbraith Road, Building B, Room 332, Cincinnati, OH 45237-1625, USAM. Olivieri, Metabolic Diseases Institute, University of Cincinnati, 2140 East Galbraith Road, Building B, Room 332, Cincinnati, OH 45237-1625, USAM. K. Haas, Metabolic Diseases Institute, University of Cincinnati, 2140 East Galb... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5315192 Tue, 11 Oct 2011 05:52:00 +0100 5315192 http://www.medworm.com/index.php?rid=5315193&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr7t77887l0v53001%2F Conclusions/interpretation  The Di@bet.es Study shows, for the first time, the prevalence rates of diabetes and impaired glucose regulation in a representative sample of the Spanish population. Content Type Journal ArticleCategory Short CommunicationPages 1-6DOI 10.1007/s00125-011-2336-9Authors F. Soriguer, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain, www.ciberdem.orgA. Goday, Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, SpainA. Bosch-Comas, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain, www.ciberdem.orgE. Bordiú, Laboratorio de Endocrinología, Hospital Universitario S. Carlos de Madrid, Madrid, SpainA. Calle-... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5315193 Tue, 11 Oct 2011 05:51:59 +0100 5315193 http://www.medworm.com/index.php?rid=5304987&cid=s_33433_15_f&fid=33433&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F170715078p28732g%2F Conclusions/interpretation  16S rDNA was shown to be an independent marker of the risk of diabetes. These findings are evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans. Content Type Journal ArticleCategory ArticlePages 1-7DOI 10.1007/s00125-011-2329-8Authors J. Amar, Inserm U1027, University Paul Sabatier, CHU, Hôpital Rangueil, Avenue Jean Pouhles, Toulouse, FranceM. Serino, Bio-Medical Research Federative Institute of Toulouse, Toulouse, FranceC. Lange, Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Villejuif, FranceC. Chabo, Bio-Medical Research Federative Institute of Toulouse, Toulouse, FranceJ. Iacovoni, ... Diabetologia journals http://www.medworm.com/rss/comments.php?id=5304987 Thu, 06 Oct 2011 06:29:29 +0100 5304987