Diagnostic Histopathology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diagnostic Histopathology' source. Thu, 09 Feb 2012 00:42:10 +0100 Editorial board http://www.medworm.com/index.php?rid=5630921&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231712000059%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5630921 Fri, 27 Jan 2012 05:38:40 +0100 5630921 Evaluating and interpreting bile duct changes in liver allograft biopsies http://www.medworm.com/index.php?rid=5630926&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001897%2Fabstract%3Frss%3Dyes Abstract: Despite great advances in treatment of liver disease, liver transplant remains the only cure for end stage liver disease and hepatocellular carcinoma. Successful management of immediate and intermediate post-transplant events determines the overall graft outcome, and pathologists play a key role in achieving long-term graft survival. In evaluating liver allograft biopsies, bile duct changes frequently pose diagnostic dilemma as they could occur in association with or the result of various causes of graft dysfunction, but in which accurate classification and interpretation is key to subsequent management. The approach to interpreting these changes share some similarity to the non-transplant liver biopsy interpretation but several additional factors come into play in transplant set... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5630926 Mon, 26 Dec 2011 05:00:00 +0100 5630926 Molecular pathology of pre-invasive breast disease in the screening setting: application in diagnosis and management http://www.medworm.com/index.php?rid=5630923&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001940%2Fabstract%3Frss%3Dyes We present a review of the molecular pathology of common pre-invasive lesions of the breast particularly discussing diagnosis on needle core biopsy, their risk of progression, and clinical management following their mammographic detection. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5630923 Thu, 22 Dec 2011 05:00:00 +0100 5630923 The clinical impact of molecular techniques on diagnostic pathology of soft tissue and bone tumours http://www.medworm.com/index.php?rid=5630925&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001927%2Fabstract%3Frss%3Dyes Abstract: Molecular techniques have become quite crucial for diagnostic histopathology. Their application in sarcomas, both in bone as well as in soft tissue, have been quite successful. Being sarcomas quite rare and diagnostically challenging, the use of ancillary molecular diagnostic tools is quite useful. Furthermore, thanks to the results of previous and ongoing research, specific genetic alterations are found to be strongly associated with several distinct mesenchymal lesions. Molecular techniques allow: 1. better disease definition and therefore more accurate diagnostics, 2. identification of molecular predictive and prognostic markers, 3. unravelling novel molecular targets for more specific therapeutic approach and eventual drug development. The pathologist has a crucial role: 1.... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5630925 Mon, 19 Dec 2011 05:00:00 +0100 5630925 Molecular typing of colorectal cancer: applications in diagnosis and treatment http://www.medworm.com/index.php?rid=5630924&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001903%2Fabstract%3Frss%3Dyes Abstract: Molecular typing of colorectal cancer (CRC) is at an early stage of development with analysis of KRAS mutation status and DNA mismatch repair (MMR) deficiency representing the two major approaches currently in use for diagnosis and treatment-related purposes. RAS proteins act as molecular switches that regulate cellular processes including cell growth and survival. Activating KRAS mutations are found in 40–50% of colorectal adenomas and cancers. Detection of KRAS mutations guide the decision to use anti-EGFR antibody therapy, which is not effective in KRAS mutant cancers. MMR deficiency results in failure to repair replication-associated DNA errors, allowing persistence of mismatch mutations all over the genome, especially in regions of repetitive DNA known as microsatellites, ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5630924 Mon, 19 Dec 2011 05:00:00 +0100 5630924 Molecular diagnostics in lymphoma: why, when and how to apply http://www.medworm.com/index.php?rid=5630922&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001939%2Fabstract%3Frss%3Dyes Abstract: Current strategies for diagnosing lymphomas include molecular methodologies next to histomorphological assessment supplemented by immunohistochemistry. Especially PCR-based clonality analysis and detection of chromosome aberrations by FISH can support the diagnosis and classification in difficult cases. We have to ensure that these existing molecular methodologies are used to their full potential. Yet, such analyses are not required in every situation. Ongoing optimization, dissemination of (new) protocols, standardized interpretation, and education are essential elements to ensure best practice for patient care. Here we discuss why, when, and how to apply these molecular diagnostic methods in the field of lymphoma. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5630922 Mon, 19 Dec 2011 05:00:00 +0100 5630922 Recent advances in the classification of hepatocellular carcinoma http://www.medworm.com/index.php?rid=5553754&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100199X%2Fabstract%3Frss%3Dyes Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and its prognosis depends largely on early detection and management. The diagnosis of HCC can be challenging, especially when dealing with scant biopsy specimens and unusual morphology. This review describes HCC subtypes with emphasis on their distinguishing histological features. Furthermore, it incorporates recently described immunohistochemical markers into an algorism for the initial approach of challenging HCC cases. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5553754 Mon, 19 Dec 2011 05:00:00 +0100 5553754 A solitary lung lesion with heterogeneous histological features http://www.medworm.com/index.php?rid=5630927&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001915%2Fabstract%3Frss%3Dyes We describe a case of this unusual tumour and consider the range of pathological differentials, which are a potential pitfall in the diagnosis. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5630927 Mon, 12 Dec 2011 05:00:00 +0100 5630927 Cholangiocarcinoma – new concepts and classifications http://www.medworm.com/index.php?rid=5478731&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001691%2Fabstract%3Frss%3Dyes Abstract: This review describes the evolving concepts of cholangiocarcinoma, from a single, relatively rare tumour to an increasing and diverse group of adenocarcinomas. It is based on the entities described in the 4th edition (2010) of the WHO classification of tumours of the digestive system. The biliary tree shares its embryological origin with the pancreatic duct, and the pathology of tumours of the large bile ducts closely resembles that of the pancreatic duct. Thus the cholangiocarcinomas that arise from large intra- and extra-hepatic bile ducts are usually highly infiltrative and desmoplastic, with frequent early dissemination and perineural infiltration. Other tumours include intraductal papillary neoplasia, and cystadenoma with ovarian-like stroma, and biliary dysplasia has been r... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478731 Thu, 01 Dec 2011 05:00:00 +0100 5478731 Introduction http://www.medworm.com/index.php?rid=5478727&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100171X%2Fabstract%3Frss%3Dyes The reviews in this mini-symposium highlight a number of recent advances in liver histopathology. These include neoplastic and non-neoplastic diseases. New developments in liver imaging and surveillance of cirrhotic patients are resulting in increased understanding of the development of primary liver cancers. Two reviews focussing on malignant liver neoplasms discuss recent advances in early hepatocellular carcinoma and in cholangiocarcinoma. The two reviews on non-neoplastic disease describe a pot pourri of miscellaneous medical conditions that may challenge the diagnostic pathologist, and present an overview of non-cirrhotic portal hypertension. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478727 Thu, 01 Dec 2011 05:00:00 +0100 5478727 Editorial board http://www.medworm.com/index.php?rid=5478726&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001812%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478726 Thu, 01 Dec 2011 05:00:00 +0100 5478726 Pathological diagnosis of hepatocellular adenoma in clinical practice http://www.medworm.com/index.php?rid=5478729&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001721%2Fabstract%3Frss%3Dyes Abstract: Hepatocellular adenomas (HCA) are rare benign liver neoplasms (solitary or multiple) that in women are usually associated with oral contraceptive use. Recent genotype-based classification of HCA has allowed the identification of three subtypes, namely, HNF1A-mutated HCA (H-HCA) in 35% of the cases, β-catenin-mutated HCA (b-HCA) in 10%, and inflammatory HCA (IHCA) in 55%. Noteworthy 10% of IHCA can be also β-catenin-mutated. Less than 10% of HCA remain unclassified.A phenotypic classification that is applicable in clinical practice has been developed from this molecular characterization. This is based on features of morphology and immunohistochemistry. Immunohistochemical analysis for liver fatty acid binding protein (for H-HCA), inflammatory proteins such as serum amyloid A or ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478729 Mon, 28 Nov 2011 05:00:00 +0100 5478729 Acinar cell carcinoma of the pancreas and related neoplasms: a review http://www.medworm.com/index.php?rid=5553751&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001769%2Fabstract%3Frss%3Dyes Abstract: Acinar cell carcinomas (ACCs) are rare tumours of the exocrine pancreas, accounting for up to 2% of all pancreatic neoplasms in adults and 15% of those in children. They are typically solid, cellular, stroma-poor tumours composed of sheets of relatively uniform cells. This sheet-like arrangement is usually punctuated by variable numbers of acinar structures. Variable amounts of neuroendocrine elements in the form of scattered individual cells are quite common, and some cases have more significant neuroendocrine or ductal elements (mixed acinar neuroendocrine carcinoma and mixed acinar ductal carcinoma).Demonstration of acinar differentiation, usually by immunohistochemistry, is necessary for the diagnosis. Among the antibodies recognizing various pancreatic enzymes, trypsin and c... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5553751 Thu, 24 Nov 2011 05:00:00 +0100 5553751 Neuroendocrine tumours of the pancreas: recent developments in staging and grading http://www.medworm.com/index.php?rid=5553750&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001733%2Fabstract%3Frss%3Dyes Abstract: A new classification of digestive neuroendocrine neoplasms, including pancreas, has been formulated in the 2010 revision of the WHO classification of tumours of the digestive system. The terminology and principles of this novel classification are different from those used previously. Three main grading categories are recognized (neuroendocrine tumour G1, neuroendocrine tumour G2 and neuroendocrine carcinoma of small and of large cell types) combined with a site-specific TNM staging, which was published in 2009 by the AJCC–UICC following a 2006 TNM proposal by the European Neuroendocrine Tumor Society.This review describes the different classifications that have been used in the last 10 years, in order to better understand the sequential modifications which have been progressive... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5553750 Wed, 23 Nov 2011 05:00:00 +0100 5553750 Reporting precursors to invasive pancreatic cancer: pancreatic intraepithelial neoplasia, intraductal neoplasms and mucinous cystic neoplasm http://www.medworm.com/index.php?rid=5553752&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001770%2Fabstract%3Frss%3Dyes We present a review of established precursor lesions of pancreatic cancer, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms (including intraductal oncocytic papillary neoplasm and intraductal tubulopapillary neoplasm), and mucinous cystic neoplasm. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5553752 Mon, 21 Nov 2011 05:00:00 +0100 5553752 Skeletal muscle pathology http://www.medworm.com/index.php?rid=5553755&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001757%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5553755 Fri, 18 Nov 2011 05:00:00 +0100 5553755 Pathology of non-cirrhotic portal hypertension and incomplete septal cirrhosis http://www.medworm.com/index.php?rid=5478730&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001678%2Fabstract%3Frss%3Dyes Abstract: This review will provide an overview of the pathological features of non-cirrhotic portal hypertension (NCPH) and incomplete septal cirrhosis (ISC), focussing on practical diagnostic approaches and problems. Although many liver diseases may be associated with portal hypertension in the absence of advanced fibrosis, the term NCPH is most widely used to describe a spectrum of changes resulting from occlusion of small portal vein branches, also referred to as “hepato-portal sclerosis” or “obliterative portal venopathy”. Other histological manifestations of NCPH include parenchymal atrophy, nodular regenerative hyperplasia, formation of shunt vessels and foci of sinusoidal dilatation. In more severe cases, foci of parenchymal collapse may be associated with formation of delic... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478730 Fri, 18 Nov 2011 05:00:00 +0100 5478730 Paraduodenal pancreatitis: a new unifying term and its morphological characteristics http://www.medworm.com/index.php?rid=5553753&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001745%2Fabstract%3Frss%3Dyes Abstract: Two inflammatory lesions represent the major differential diagnosis of pancreatic cancer clinically and on imaging: autoimmune (IgG4) pancreatitis and paraduodenal pancreatitis. This latter lesion has been described under various denominations, especially in most early reports by using the term “cystic dystrophy developed in heterotopic pancreas”. Most cases present in young alcoholic males as cystic and inflammatory mass forming lesions centred in the duodenum and the juxtaduodenal pancreatic tissue, predominating in the region of the minor papilla. They may be associated with chronic calcifying pancreatitis. Pathogenetically, key factors are alcohol and anatomical or functional obstruction of the papilla minor. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5553753 Mon, 14 Nov 2011 05:00:00 +0100 5553753 Liver cell dysplasia and early hepatocellular carcinoma http://www.medworm.com/index.php?rid=5478728&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001666%2Fabstract%3Frss%3Dyes Abstract: Hepatocellular carcinoma (HCC) is a major world health problem. Screening and diagnosis of early lesions of HCC allows prompt treatment to improve clinical outcomes. Early lesions of HCC include premalignant lesions and small HCCs. The former consists of hepatocellular cytological changes (large cell change, small cell change and iron-free foci), dysplastic foci and dysplastic nodules (low-grade and high-grade); while the latter is subdivided into early HCC and progressed HCC. There is significant overlap in pathological and radiological features between high-grade dysplastic nodules and early HCC making a precise diagnosis demanding even among experts. Various conventional and emerging potential diagnostic markers have been evaluated in assisting pathological diagnosis of early ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478728 Thu, 10 Nov 2011 05:00:00 +0100 5478728 Recent advances in medical liver disease http://www.medworm.com/index.php?rid=5478732&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001654%2Fabstract%3Frss%3Dyes Abstract: This review surveys recent publications on medical liver diseases that might be of interest to diagnostic histopathologists. Topics highlighted include haemochromatosis, autoimmune hepatitis, sepsis in cirrhosis, haemophagocytic syndromes, IgG4-associated hepatobiliary diseases, anorexia nervosa, progressive familial intrahepatic cholestasis, chemotherapy-induced liver injury, cystic fibrosis, obliterative portal venopathy and practical assessment of ductopenia in needle biopsies. Each section covers recent developments and highlights practical considerations in clinicopathological diagnosis. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478732 Mon, 07 Nov 2011 05:00:00 +0100 5478732 Diagnostic challenges in a rare case of müllerian adenofibroma of the uterus: instructive case and literature review http://www.medworm.com/index.php?rid=5478733&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100168X%2Fabstract%3Frss%3Dyes We report the clinical, radiological and pathological features of a case of extremely rare müllerian adenofibroma of endometrium in a postmenopausal woman. Although tumour is benign, histopathological features of adenofibroma overlap with its malignant müllerian counterpart, adenosarcoma. A case is presented in which a 60-year-old woman with adenofibroma of endometrium was initially treated with curettage rather than hysterectomy. The radiological imaging was of limited value in specifically diagnosing müllerian adenofibroma and it will virtually never indicate this as a specific diagnosis. Furthermore, the diagnosis of adenofibroma in our patient could not be reliably made from curettage samples only, necessitating further follow-up. Another curettage 2 months later showed the recurren... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5478733 Wed, 02 Nov 2011 04:00:00 +0100 5478733 The neuropathological approach to the diagnosis of brain tumours http://www.medworm.com/index.php?rid=5350388&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001381%2Fabstract%3Frss%3Dyes Abstract: This review provides an introduction to the concepts and practical aspects concerning the diagnosis of neoplasms involving the brain. Principles of the WHO classification are described, including concepts of lineage origin of brain tumours and aetiology (environment versus genetic predisposition). The importance of neuroimaging in the context of the intraoperative diagnostic approach and formulation of differential diagnoses is emphasized. A brief overview of immunohistochemical markers is provided. Common cytological and architectural patterns are illustrated with educational case material. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5350388 Thu, 27 Oct 2011 05:51:33 +0100 5350388 Editorial board http://www.medworm.com/index.php?rid=5350387&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001575%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5350387 Thu, 27 Oct 2011 05:51:33 +0100 5350387 The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context http://www.medworm.com/index.php?rid=5350390&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001423%2Fabstract%3Frss%3Dyes Abstract: Gliomas form a heterogeneous group of tumours of the central nervous system. Most gliomas, the so-called ‘diffuse gliomas’, are characterized by diffuse infiltrative growth in the neuropil. Based on histopathological analysis, diffuse gliomas are subdivided in astrocytic, oligodendroglial, and oligoastrocytic tumours and graded as WHO grade II (low grade), WHO grade III (anaplastic), or WHO grade IV (glioblastoma). Accurate distinction between the different diffuse glioma types and malignancy grades has significant prognostic and therapeutic implications. This review describes essential aspects of the microscopic diagnosis of diffuse gliomas. Because of problems with tissue sampling and imprecise criteria for typing and grading, unequivocal histopathological classification of... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5350390 Mon, 03 Oct 2011 04:00:00 +0100 5350390 Thyroid pathology http://www.medworm.com/index.php?rid=5350392&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001411%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5350392 Mon, 26 Sep 2011 04:00:00 +0100 5350392 Pathology of polyps detected in the bowel cancer screening programme http://www.medworm.com/index.php?rid=5350391&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001393%2Fabstract%3Frss%3Dyes Abstract: The success of the UK Bowel Cancer Screening Programme (BCSP) is dependent on reliable diagnosis and effective clinical management of pre-invasive adenomatous polyps. As the malignant potential of colorectal adenomas is highly variable, the purpose of histological assessment is to identify patients who will require subsequent surgery or regular colonoscopic surveillance. Our review encompasses the histopathology and differential diagnosis of screen-detected polyps, focusing on features which discriminate lesions at highest risk of malignant transformation. We explore some of the diagnostic challenges confronting screening pathology, including the characterization of serrated lesions and common mimics of dysplasia and malignancy. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5350391 Mon, 19 Sep 2011 04:00:00 +0100 5350391 Adenomas of the pituitary gland: diagnostic challenges, pitfalls and controversies http://www.medworm.com/index.php?rid=5350389&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100140X%2Fabstract%3Frss%3Dyes Abstract: Pituitary adenomas account for about 10% of intracranial tumours and 90% of intrasellar lesions. They are classified according to histopathological and ultrastructural features and hormone immunoexpression but a comprehensive diagnosis requires a full knowledge of clinical and neuroimaging features. If the common histotypes can be easily identified at light microscopy, the diagnosis of rare variants can be challenging and may require ultrastructural examination or the use of more sophisticated immunostains. Similarly challenging and source of diagnostic pitfalls can be the changes that may occur during surgery or following medical treatment. Finally, controversies still surround the concept of atypical adenoma and pituitary carcinoma making a histopathological diagnosis of aggres... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5350389 Mon, 19 Sep 2011 04:00:00 +0100 5350389 Editorial board http://www.medworm.com/index.php?rid=5212535&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001460%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5212535 Tue, 13 Sep 2011 08:34:06 +0100 5212535 A practical approach to colitis http://www.medworm.com/index.php?rid=5149089&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001125%2Fabstract%3Frss%3Dyes This article aims to provide the reader with a review of the most commonly encountered inflammatory processes of the colon and to offer guidance to differentiate between entities bearing in mind that there is significant overlap between many of these disorders. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5149089 Wed, 24 Aug 2011 20:46:09 +0100 5149089 The serrated pathway of neoplasia: new insights into an evolving concept http://www.medworm.com/index.php?rid=5149088&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001010%2Fabstract%3Frss%3Dyes Abstract: Twenty years ago, the only known pathway of colorectal carcinoma was the adenoma-carcinoma sequence; while profoundly important, this pathway does not account for all cases of colorectal carcinoma. Today the serrated pathway is recognized as an alternative pathway to colorectal carcinoma. The signature features of the serrated pathway include sessile serrated adenomas, microsatellite instability, and the potentially rapid conversion to malignancy. The family of histologically serrated lesions also encompasses traditional serrated adenoma and variants such as the filiform serrated adenoma, serrated epithelial change/dysplasia, and, potentially, colonic perineurioma. This review highlights key morphologic and molecular concepts in the serrated pathway of neoplasia, and discusses ho... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5149088 Wed, 24 Aug 2011 20:46:09 +0100 5149088 Editorial board http://www.medworm.com/index.php?rid=5149087&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001290%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5149087 Wed, 24 Aug 2011 20:46:09 +0100 5149087 Benign mimickers and potential precursors of prostatic adenocarcinoma http://www.medworm.com/index.php?rid=5212538&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100106X%2Fabstract%3Frss%3Dyes Abstract: The diagnosis of prostatic adenocarcinoma (PCa) in needle biopsy, especially when present in small amounts, is often challenging. Before making a malignant diagnosis, it is imperative to consider and rule out various benign processes that can simulate cancer. A useful method of classifying benign mimickers is in relationship to the major architectural patterns depicted in the Gleason diagram. The four major patterns are small gland, large gland, fused gland and solid nests and single cells. Most mimickers have small gland architecture and include atrophy, post-atrophic hyperplasia and atypical adenomatous hyperplasia. Normal anatomical and vestigial structures such as seminal vesicle/ejaculatory duct tissue, Cowper’s gland, verumontanum mucosal glands, mesonephric glands and p... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5212538 Fri, 12 Aug 2011 04:00:00 +0100 5212538 Recent progress of IgG4-related hepatobiliary diseases with emphasis on pathologic aspects and differential diagnosis http://www.medworm.com/index.php?rid=5212540&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001058%2Fabstract%3Frss%3Dyes In conclusion, several hepatobiliary diseases which had been diagnosed as other diseases, can be reclassified as IgG4-related diseases, and several local factors peculiar to the hepatobiliary system may be responsible for the development of these diseases. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5212540 Mon, 08 Aug 2011 04:00:00 +0100 5212540 The Gleason grading system: where are we now? http://www.medworm.com/index.php?rid=5212536&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001034%2Fabstract%3Frss%3Dyes Abstract: The most commonly used pathologic grading system for prostatic carcinoma (PCa) was first described by Donald F. Gleason in 1966. It is remarkable that, more than 40 years after the inception of the Gleason grading system, it remains one of the most powerful prognostic factors in prostate cancer. In part, this system has remained timely by gradual adaptations of the system to accommodate the changing practice of medicine. The 2005 International Society of Urological Pathology (ISUP) conference helped to codify these adaptations as well as gain consensus in areas where there was divergence in practice. The consensus conference and subsequent articles proposing further modifications help pathologists adapt the Gleason grading system to current day practice in a more uniform manner. ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5212536 Mon, 08 Aug 2011 04:00:00 +0100 5212536 An unusual cardiac tumour found at post-mortem http://www.medworm.com/index.php?rid=5212541&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001095%2Fabstract%3Frss%3Dyes Abstract: This is a case of a 77-year-old man who was admitted to hospital complaining of palpitations, dizziness and sweating. During his hospital admission he was treated for various arrhythmias. An echocardiogram was performed which detected a possible infiltrative mass within the right ventricle but a subsequent echocardiogram showed right ventricular hypertrophy. Whilst awaiting further investigations, the patient self discharged and unfortunately died suddenly at home. An autopsy was conducted which showed a large tumour mass infiltrating the full wall thickness of the right ventricle with extension towards the right atria. The remaining heart structures were otherwise normal.Histological examination of the cardiac tumour showed a diffuse infiltration of atypical lymphoid cells with ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5212541 Fri, 05 Aug 2011 04:00:00 +0100 5212541 Prognostic markers in colorectal pathology: is morphology enough? http://www.medworm.com/index.php?rid=5149090&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001113%2Fabstract%3Frss%3Dyes Abstract: Colorectal cancer is the second commonest cause of cancer-related death after lung cancer. Adjuvant chemotherapy has become the standard of care for patients with stage III colon cancer. However, there is a need for better risk stratification in stage II disease where a significant proportion of patients are at risk of disease recurrence and controversy still exists on the role of chemotherapy. This can be achieved by the application of standardized morphological features in a consistent manner, many of which are associated with hazard ratios beyond what can be achieved by new molecular biomarkers. Molecular biomarkers, however, have promise in this setting and may be more precise, with the added advantage of being predictive and thus individualizing therapy. (Source: Diagnostic ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5149090 Sun, 31 Jul 2011 23:00:00 +0100 5149090 Grading sarcomas: histologic and molecular approaches http://www.medworm.com/index.php?rid=5081978&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000855%2Fabstract%3Frss%3Dyes Abstract: Histological grading, that is, grading based only on histological parameters, evaluates the degree of malignancy and the probability of distant metastasis for cancer. Several grading systems have been reported for sarcomas but the two most widely-used systems are the National Cancer Institute and the French systems. Histological grade is recognized as the most important prognostic factor for soft tissue sarcomas. However, this approach presents several limitations such as moderate reproducibility, existence of an intermediate grade and the current nearly universal use of core needle biopsies. A molecular grading system which significantly outperforms histological grading has been recently described for sarcomas. It is based on the expression profile of 67 genes related to chromos... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5081978 Sun, 31 Jul 2011 23:00:00 +0100 5081978 Editorial board http://www.medworm.com/index.php?rid=5081977&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001186%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5081977 Sun, 31 Jul 2011 23:00:00 +0100 5081977 Handling and reporting of radical prostatectomy specimens http://www.medworm.com/index.php?rid=5212537&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001022%2Fabstract%3Frss%3Dyes Abstract: An accurate reporting of radical prostatectomy specimens is becoming more important as we gain insights in how cancer therapy should be taylored according to risk stratification. The handling of these specimens must therefore be standardized and enable the correct identification of histopathological risk factors for poor outcome. Several efforts have been made in recent years to reach consensus on the handling and reporting of radical prostatectomy specimens. Some of the recommendations are summarized in this review, including guidelines for gross description, fixation, cutting and reporting of stage and grade related data. Methods for biobanking of fresh tissue are also described. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5212537 Fri, 29 Jul 2011 04:00:00 +0100 5212537 Self-assessment: gynaecological pathology http://www.medworm.com/index.php?rid=5149093&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001046%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5149093 Thu, 28 Jul 2011 23:00:00 +0100 5149093 The neoplastic appendix: a practical approach http://www.medworm.com/index.php?rid=5149091&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001071%2Fabstract%3Frss%3Dyes Abstract: Neoplastic processes in the appendix are histologically similar to their colonic counterparts, and recognition of these neoplasms is relatively straightforward. However, reporting and tumour staging of the neoplastic appendix can be complex, given numerous proposed classification systems, the uncertainty surrounding extra-appendiceal spread, and the frequently low-grade histology. Prognostication and clinical decisions regarding treatment rely heavily upon the completeness of the pathology report. This review discusses the clinicopathologic features of the epithelial neoplasms of the appendix, including colonic-type (non-mucinous) adenomas and adenocarcinomas, mucinous neoplasms, classical carcinoid tumours (well-differentiated neuroendocrine tumours), and goblet cell carcinoids ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5149091 Thu, 28 Jul 2011 23:00:00 +0100 5149091 Immunohistochemistry in prostate neoplasia: pitfalls and progress http://www.medworm.com/index.php?rid=5212539&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001083%2Fabstract%3Frss%3Dyes Abstract: Prostatic immunohistochemistry is commonly used to either distinguish prostatic adenocarcinoma from benign prostate glands or to establish the prostatic lineage of a poorly differentiated carcinoma. Awareness of the many potential pitfalls in prostatic immunohistochemistry is essential to avoid serious misdiagnosis. Histopathologists must be particularly aware of the pitfalls in the interpretation of immunostained sections (identifying immunostaining as positive or negative) and in the interpretation of the immunoprofile of a tumour. This review describes pitfalls at the pre-analytic, analytic and post-analytic stages of testing with a particular focus on the pitfalls in the interpretation stage together with advice on steps that must be taken to avoid these pitfalls. The importa... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5212539 Tue, 26 Jul 2011 04:00:00 +0100 5212539 Histopathology of iatrogenic injury in the colorectum http://www.medworm.com/index.php?rid=5149092&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001101%2Fabstract%3Frss%3Dyes Abstract: Medical interventions may cause histologic changes and injury to the colorectal mucosa. Many of these changes overlap with one another and with medical gastrointestinal disease, such as inflammatory bowel disease. This review focuses on common causes of iatrogenic injury and the histologic patterns seen on mucosal biopsies. Topics covered include: 1. Endoscopy-induced artefacts, including mucosal pseudolipomatosis, pneumatosis coli, crush and cautery artefacts, and disinfectant colitis; 2. Changes induced by surgery and other therapies, including diversion colitis, radiation colitis, and graft versus host disease; and 3. Changes induced by drugs and toxins, including melanosis coli, chemotherapy, non-steroidal-anti-inflammatory drugs, mycophenolate, kayexalate, and bowel preparat... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5149092 Sun, 24 Jul 2011 23:00:00 +0100 5149092 A brief history and contemporary re-assessment of malignant fibrous histiocytoma: “fact or fancy” http://www.medworm.com/index.php?rid=5081980&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711001137%2Fabstract%3Frss%3Dyes Abstract: There is a group of tumors which has been thought to include ‘histiocyte-like’, ‘fibroblast-like’and ‘myo-fibroblast-like’ cells that has been repeatedly expanded and collapsed over several decades as our methods of examining these tumors has advanced. In this review, we examine the history and present state of malignant fibrous histiocytoma. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5081980 Thu, 21 Jul 2011 23:00:00 +0100 5081980 Expression of growth hormone receptors in colorectal carcinoma http://www.medworm.com/index.php?rid=5081982&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000880%2Fabstract%3Frss%3Dyes Abstract: Colorectal cancers are the third most common cancers in the western world and among its aetiological factors, hormones are considered to play an important role. Growth hormone is a general metabolic hormone which promotes growth and differentiation throughout the body. Whether growth hormone has any direct effects in the aetiology and pathogenesis of colorectal cancers has not been unequivocally established, although epidemiological data and in-vitro studies suggest a link. Growth hormone exerts its effects on the cells through its receptor, which is a transmembrane glycoprotein. A few studies have looked at the expression of growth hormone receptors in colorectal cancers. The aim of this article was to review the evidence available in literature and determine the link between th... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5081982 Thu, 07 Jul 2011 23:00:00 +0100 5081982 Basic cytomorphology of pancreatic lesions http://www.medworm.com/index.php?rid=5012722&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000818%2Fabstract%3Frss%3Dyes Abstract: In patients with a palpable or radiologically identified pancreatic lesion, FNA is a safe and accurate procedure for procuring diagnostic material. Complications of the procedure are rare, and the morbidity and mortality are considerably less than that associated with open laparotomy and wedge biopsy. The most common complication associated with pancreatic FNA is acute pancreatitis. Contraindications to FNA include an uncorrectable bleeding diathesis, and marked ascites. The accuracy of FNA for diagnosing pancreatic adenocarcinoma is about 90%, and the overall sensitivity can be increased by multiple needle passes. Close communication and collaboration among the clinician, radiologist, and pathologist can help assure that suitable tissue is obtained and maximize the diagnostic yi... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5012722 Wed, 06 Jul 2011 23:00:00 +0100 5012722 Anal duct carcinoma in a 70-year-old male with a history of prostate cancer http://www.medworm.com/index.php?rid=5081983&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000892%2Fabstract%3Frss%3Dyes We report a case of anal duct carcinoma diagnosed in a 70-year-old male with a history of treated prostate cancer. The epidemiology, clinical presentation, histologic features, differential diagnosis, treatment, and prognosis of anal duct carcinoma are discussed. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5081983 Sun, 03 Jul 2011 23:00:00 +0100 5081983 Diagnosing sarcomas: the role of experience http://www.medworm.com/index.php?rid=5081979&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000867%2Fabstract%3Frss%3Dyes Abstract: Soft tissue sarcomas are rare but have numerous subtypes, and both benign and malignant soft tissue tumours can show considerable morphological variation. With increasing subspecialization, histopathologists become less skilled outside their areas of practice, and it can be difficult for an inexperienced pathologist to assess malignancy, subtype and grade of a sarcoma as required for management. In different clinicopathological settings, there is a consistent discrepancy rate between referring and expert diagnoses of approximately 25% for diagnosis and grading, with about a 5% malignant-benign change.Soft tissue tumour specimens should therefore be reported by specialist pathologists, within a multidisciplinary team. Furthermore, outcomes are better in specialized centres with de... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5081979 Sun, 03 Jul 2011 23:00:00 +0100 5081979 Self-assessment: liver pathology http://www.medworm.com/index.php?rid=5012725&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000843%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5012725 Sun, 03 Jul 2011 23:00:00 +0100 5012725 Editorial board http://www.medworm.com/index.php?rid=5012719&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000934%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5012719 Thu, 30 Jun 2011 23:00:00 +0100 5012719 The impact of advances in molecular genetics on the classification and diagnosis of liposarcoma http://www.medworm.com/index.php?rid=5081981&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000879%2Fabstract%3Frss%3Dyes This article will summarize our current knowledge of the cytogenetic and molecular genetic basis of liposarcomas specifically, and will review the impact of advances in these fields on the classification and diagnosis of these tumours. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5081981 Wed, 29 Jun 2011 23:00:00 +0100 5081981 Fine needle aspiration: a changing paradigm http://www.medworm.com/index.php?rid=5012720&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000806%2Fabstract%3Frss%3Dyes Abstract: Fine needle aspiration (FNA) is used routinely for detection, diagnosis, therapeutics and follow-up of various tumours. This practice is recognized as an accurate, rapid and economical diagnostic procedure. In the rapidly changing healthcare paradigm, however, there are new challenges being imposed on the practice of fine needle aspiration cytopathology. The diagnosis of FNA specimens must not only be accurate it should be precise. This puts additional demands on the clinicians, the cytopathologists and the laboratory; slide preparations and reporting must meet not only the diagnostic but also the therapeutic challenges. This requires a multimodal approach and interaction among the various parties including the patient, the primary care, the radiology, molecular and cytopathology... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5012720 Wed, 29 Jun 2011 23:00:00 +0100 5012720 Utility of fine needle aspiration cytology in the diagnosis of infective lesions http://www.medworm.com/index.php?rid=5012723&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100082X%2Fabstract%3Frss%3Dyes Abstract: With migration of people, a lesion caused by an infectious agent may present anywhere in the globe, whether the disease is endemic or not to that particular geographical area. Many times the cytopathologist is the first expert to assess the lesion, whether an infectious aetiology is clinically suspected or not. One should have a fair knowledge of various cytomorphological presentations and light microscopic appearances of the microbes to give a valuable clue to the diagnosis. This review attempts at giving a working knowledge of different pathogenic microbes encountered in fine needle aspiration cytology. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5012723 Sun, 26 Jun 2011 23:00:00 +0100 5012723 Possible use and role of molecular techniques in fine-needle aspiration cytology (FNAC) practice http://www.medworm.com/index.php?rid=5012721&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000831%2Fabstract%3Frss%3Dyes Abstract: Fine-needle aspiration cytology (FNAC) is a recognized ancillary tool in the diagnosis of tumours and infectious diseases. Throughout decades cytopathologists did tremendous marvels with pure morphologic criteria, diagnosing in shrinking amounts of material. The recent understanding of complex cancer biology reshapes the practice of FNAC. The scientific advance of image techniques gave cytopathologists the possibility to go to deep locations and collecting material from previous unlikely locations. This conjunction of knowledge’s and techniques has increased the role of FNAC in the diagnosis, prognosis and in the establishment of new therapeutic targets. Lately, core needle biopsy is gaining popularity and advantage regarding FNAC. The sample limitation of FNAC regarding immuno... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5012721 Sun, 26 Jun 2011 23:00:00 +0100 5012721 Diffuse deciduosis occurring within an ovarian cystadenoma – a clinical–pathological mimic of a malignant process http://www.medworm.com/index.php?rid=5012724&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100079X%2Fabstract%3Frss%3Dyes Abstract: Deciduosis is a term referred to foci of ectopic decidualized stromal cells thought to be due to a form of “stromal mullerianosis”. The changes are commonly observed in association with pregnancy and are sometimes secondary to exogenous progesterone administration. Deciduosis of various sites have been reported, some of which include the peritoneal surfaces of pelvic and abdominal structures. Deciduosis is usually an incidental finding at caesarean section and runs an asymptomatic benign course, though some articles have reported rarer cases associated with potentially fatal haemoperitoneum, dystocia, and even symptoms mimicking acute bowel obstruction. Although not always clinically significant, deciduosis can prove a difficult diagnostic dilemma clinically and on histopatho... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=5012724 Thu, 16 Jun 2011 23:00:00 +0100 5012724 Editorial board http://www.medworm.com/index.php?rid=4906681&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000697%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4906681 Tue, 31 May 2011 23:00:00 +0100 4906681 Thyroid cytology http://www.medworm.com/index.php?rid=4906686&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000491%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4906686 Tue, 24 May 2011 23:00:00 +0100 4906686 TNM staging system of colorectal carcinoma: surgical pathology of the seventh edition http://www.medworm.com/index.php?rid=4906682&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000521%2Fabstract%3Frss%3Dyes Abstract: There is a need for internationally standardized staging of tumours so that various parameters, such as stage at presentation, can be compared in epidemiological data from different countries and regions and in the study populations in published research studies. These staging systems require periodic revision to improve the robustness of the categories and to take account of any advances in understanding of the tumour biology. However whenever changes are made to a staging system the boundaries between categories may alter and there may be a shift in cases from one category in the previous system into a lower or higher stage in the new system. This can affect the meta-analysis of studies published over a long period of time. This review examines the latest revision of the stagin... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4906682 Sun, 08 May 2011 23:00:00 +0100 4906682 Approach to the post-mortem investigation of neurodegenerative diseases: from diagnosis to research http://www.medworm.com/index.php?rid=4750062&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100034X%2Fabstract%3Frss%3Dyes Abstract: Neurodegenerative diseases are common. Establishing a precise post-mortem diagnosis of one of these disorders is necessary to accurately attribute the cause of death, to determine familial risk and to inform clinicopathological correlation. However, to the non-specialist this may appear to be a daunting prospect. In this article we provide an overview of the clinical and neuropathological features of common neurodegenerative diseases and suggest an approach to the post-mortem examination when a neurodegenerative disease is suspected. We conclude by outlining the vital role that brain banks have in furthering our understanding of these diseases. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4750062 Tue, 26 Apr 2011 18:36:34 +0100 4750062 Editorial board http://www.medworm.com/index.php?rid=4750061&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000582%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4750061 Tue, 26 Apr 2011 18:36:34 +0100 4750061 Pseudoepitheliomatous tattoo reaction http://www.medworm.com/index.php?rid=4906685&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100048X%2Fabstract%3Frss%3Dyes Abstract: With the rising popularity of tattoos, adverse skin reactions to this practise are being increasingly recognized. Most tattoo reactions involve dermal inflammatory changes. Florid pseudoepitheliomatous hyperplasia is a rare and poorly recognized complication of tattooing. Lack of awareness of this association may result in a misdiagnosis of squamous cell carcinoma. Careful consideration of the clinicopathological context is of paramount importance to make this distinction. Although exceptionally rare, genuine squamous cell carcinoma and keratoacanthoma can sometimes develop in tattoo sites. Because of this, full thickness biopsies and complete excision of the hyperproliferative area should be recommended. In contrast to pseudoepitheliomatous hyperplasia, a squamous cell carcinoma... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4906685 Sun, 24 Apr 2011 23:00:00 +0100 4906685 Diagnostic categorization in EQA schemes http://www.medworm.com/index.php?rid=4906684&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100051X%2Fabstract%3Frss%3Dyes Abstract: The different ways in which diagnoses may be categorized in EQA schemes are considered. They may be grouped in very large diagnostic categories, or in narrow specific diagnoses. They may be categorized as dangerous or non-dangerous diagnoses. They may be categorized by the participants or a panel of experts. They may be categorized according to organ system, but rarely by underlying pathological process. The ways in which these categories are reached is considered, and the effect this has on the educational role of EQA schemes. This categorization will also influence the participant’s strategy to ensure that they are not categorized as a poor performer. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4906684 Sun, 24 Apr 2011 23:00:00 +0100 4906684 Grading in histopathology http://www.medworm.com/index.php?rid=4906683&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000508%2Fabstract%3Frss%3Dyes Abstract: Grading is the process of subdividing a diagnostic category to increase the amount of information in a histopathology report and so assist clinicians in making individual therapeutic decisions. A good grading system will have a high signal to noise ratio with good inter- and intra-observer agreement. Many grading systems in histopathology have been produced by a top-down design process which does not take into account the natural distribution of cases. Such systems may produce very poor results if the arbitrary boundaries of the grading system do not coincide with the natural boundaries of clusters of cases. This review examines the fundamental processes involved in grading and demonstrates bottom-up design processes which have the potential to produce effective grading systems. ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4906683 Thu, 21 Apr 2011 23:00:00 +0100 4906683 Ovarian borderline tumours: a review with emphasis on controversial areas http://www.medworm.com/index.php?rid=4647244&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000478%2Fabstract%3Frss%3Dyes Abstract: Ovarian borderline tumours are relatively uncommon, but by no means rare, neoplasms. Most are of serous or mucinous type with other morphological variants being much more uncommon. This review discusses the pathological features and some clinical aspects of ovarian borderline tumours, concentrating on those of serous and mucinous type. Borderline endometrioid, Brenner and clear cell tumours are briefly discussed. Controversial and often poorly understood topics covered include the relationship between borderline tumours and carcinomas, the criteria for and significance of microinvasion, the significance of a micropapillary architecture in a serous borderline tumour, the diagnostic criteria for and significance of extraovarian “implants”, lymph node involvement, staging issues... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4647244 Tue, 29 Mar 2011 21:12:46 +0100 4647244 Editorial board http://www.medworm.com/index.php?rid=4647241&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000405%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4647241 Tue, 29 Mar 2011 21:12:45 +0100 4647241 Cavity margins examination in breast-conserving therapy http://www.medworm.com/index.php?rid=4750065&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000351%2Fabstract%3Frss%3Dyes Abstract: There is a good consensus that the pathologic lumpectomy margin status is the most important factor to determine the risk of local recurrence of carcinoma after breast-conserving therapy. However, there is no consensus regarding the definition of a complete excision or an adequate margin and the reported rates of repeat surgery for positive margins range from 10 to 57%. Therefore, an alternative technique of margin evaluation, called cavity shaving or cavity margin shaving has been proposed and applied by some surgical teams in order to reduce the need for re-excisions and to detect multifocality. We aim to describe in this review how to handle, analyse and report breast lumpectomy specimens with associated cavity margins and to discuss the potential advantages and drawbacks of t... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4750065 Fri, 25 Mar 2011 00:00:00 +0100 4750065 Prion diseases: a primer for general pathologists http://www.medworm.com/index.php?rid=4750063&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000326%2Fabstract%3Frss%3Dyes Abstract: Prion diseases are fatal and transmissible central nervous system disorders characterized by progressive loss of neurons and spongiform degeneration (“spongiform encephalopathy”). Prion diseases have various aetiologies. In this review, we focus on clinical and neuropathological features, distribution of tissue infectivity, and precautionary measures during autopsy relevant for general pathology practice. Prion disease is suspected clinically by the observation of complex and rapidly progressive neuropsychiatric symptoms. In vivo supportive diagnostic tests include EEG, cranial MRI, and detection of protein 14-3-3 in the cerebrospinal fluid. Awareness of the disease and efforts to perform neuropathological examination are the main duties of general pathologists. An accurate h... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4750063 Thu, 24 Mar 2011 00:00:00 +0100 4750063 Minimal deviation Barrett’s adenocarcinoma: a diagnostic challenge http://www.medworm.com/index.php?rid=4750066&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000338%2Fabstract%3Frss%3Dyes We report progression in a 60-year-old male of an exceptionally well differentiated oesophageal adenocarcinoma to pT3 pN1 despite surveillance. Extremely well differentiated Barrett’s adenocarcinoma has some similarity with adenoma malignum of the uterine cervix. Lack of glandular maturation, loss of mucosal polarization and glands in unusual loci are clues to the diagnosis in a background of Barrett’s dysplasia. The role of surveillance endoscopy for Barrett’s oesophagus remains controversial, but this case emphasizes the need for high quality histopathology and clinical correlation when Barrett’s surveillance is undertaken. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4750066 Mon, 21 Mar 2011 00:00:00 +0100 4750066 The pathology of multiple sclerosis and related disorders http://www.medworm.com/index.php?rid=4750064&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000314%2Fabstract%3Frss%3Dyes Abstract: The histopathology of multiple sclerosis (MS), the most common demyelinating disorder, is the main focus of this review. MS is characterized by inflammatory demyelination, accompanied by gliosis. The MS plaque can show ongoing active demyelination, which can be accompanied by varying degrees of remyelination, or be quiescent. The current concept that MS is an autoimmune disease of myelin has been challenged by recent studies, and it is becoming increasingly clear that neurodegeneration is a significant component of the disease and may largely account for its progressive disability. Other disorders related to MS that are briefly discussed here are acute disseminated encephalomyelitis, acute haemorrhagic leucoencephalitis, neuromyelitis optica and progressive multifocal leucoenceph... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4750064 Fri, 18 Mar 2011 00:00:00 +0100 4750064 Non-epithelial ovarian tumours: a review of selected patterns that mimic epithelial tumours and other high-grade malignancies http://www.medworm.com/index.php?rid=4647242&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000156%2Fabstract%3Frss%3Dyes Abstract: Non-epithelial ovarian tumours exhibit a diverse array of growth patterns that can mimic epithelial ovarian cancers or other high-grade malignancies. This review highlights selected morphologic features that may assist in the differential diagnosis, as well as recent advances in immunohistochemistry. Steroidogenic factor-1 is a novel marker for sex cord-stromal differentiation and is useful in the diagnosis of granulosa cell tumour. SALL4 is a novel marker of primitive germ cell tumours and is useful in the diagnosis of yolk sac tumour. Distinction of primary versus metastatic origin of carcinoid tumour is important and gross and microscopic features are more accurate to this end than immunohistochemistry, except for the value of TTF-1 in pulmonary or cervical neuroendocrine tumo... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4647242 Tue, 08 Mar 2011 00:00:00 +0100 4647242 Giant infantile plexiform cellular schwannoma of the knee http://www.medworm.com/index.php?rid=4647246&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000144%2Fabstract%3Frss%3Dyes We describe an infant with a painless but rapidly enlarging plexiform cellular schwannoma over the anterior aspect of the knee. It is a diagnostic challenge for the histopathologist to differentiate between plexiform schwannoma and a malignant peripheral nerve sheath tumour or plexiform neurofibroma which has an association with neurofibromatosis type 1 and carries a risk of sarcomatous change. This benign peripheral nerve sheath tumour is characterised by a multinodular and plexiform growth pattern. To date no report has been published in the European literature describing a rapidly growing giant plexiform cellular schwannoma in an infant. This diagnostic dilemma and rarity of this condition are the unique features of this case report. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4647246 Mon, 07 Mar 2011 00:00:00 +0100 4647246 Typing of ovarian carcinomas: an update http://www.medworm.com/index.php?rid=4647243&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171100017X%2Fabstract%3Frss%3Dyes Abstract: Classification of ovarian carcinomas into different subtypes is no longer only an exercise in pattern recognition that lacks clinical and biological significance. Biologically validated diagnostic criteria now separate ovarian carcinomas into specific disease types that have clinical relevance: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, clear cell carcinoma and primary ovarian mucinous carcinoma. This review summarizes the clinical and pathologic features of these types of ovarian carcinoma and provides information about refined diagnostic criteria and the use of ancillary diagnostic techniques for diagnosis. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4647243 Mon, 07 Mar 2011 00:00:00 +0100 4647243 Metastatic CIN3-like squamous carcinoma http://www.medworm.com/index.php?rid=4585128&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001933%2Fabstract%3Frss%3Dyes We report a case of squamous carcinoma with CIN3-like growth pattern, which metastasized to psoas muscle 13 years following cone biopsy reported as CIN3 with a small focus of microinvasion. This is an unusual case in several aspects: (a) it had the histological features of squamous carcinoma with CIN3-like growth pattern, a subvariant of cervical squamous carcinoma, which is often under-diagnosed as CIN3 with possible early stromal invasion, (b) the endometrial epithelium in the subsequent hysterectomy specimen was entirely replaced by similar pathology (CIN3-like growth pattern), (c) pathology of the distant metastasis, which occurred several years after hysterectomy, also revealed CIN3-like growth pattern. This case raises awareness of the entity of squamous carcinomas with CIN3-like gr... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585128 Tue, 01 Mar 2011 00:00:00 +0100 4585128 Update on clinically important variants of papillary thyroid carcinoma http://www.medworm.com/index.php?rid=4585125&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001957%2Fabstract%3Frss%3Dyes Abstract: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, as well as the most common endocrine malignancy. Universally, PTC has an excellent clinical prognosis, even with local lymph node involvement at initial surgery. Over the past 20 years, numerous morphologic variants of PTC have been defined. These variants demonstrate a range of biologic aggressiveness, despite an overall favourable outcome for all variants. Molecular changes in PTC have been recognized for some time, most notably BRAF (V600E) mutations, but also mutations in KRAS, HRAS, NRAS, as well as RET/PTC rearrangements. Detection of these genetic anomalies may have diagnostic significance and possibly prognostic significance, since some of the more typically thought of aggressive variants have a high... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585125 Tue, 01 Mar 2011 00:00:00 +0100 4585125 Editorial board http://www.medworm.com/index.php?rid=4585123&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000223%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585123 Tue, 01 Mar 2011 00:00:00 +0100 4585123 Primary cardiac low grade sarcomas mimicking myxomas. Pitfall in diagnosis http://www.medworm.com/index.php?rid=4647247&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000168%2Fabstract%3Frss%3Dyes Abstract: Cardiac sarcomas can resemble myxomas macroscopically and microscopically. These tumours can be easily misdiagnosed unless examined carefully. The presence of spindle cells with mitoses, hypercellular areas the formation of a cellular “cambium” layer beneath the surface and/or an unusual location of the tumour are often helpful in recognizing the true nature of these tumours. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4647247 Mon, 28 Feb 2011 00:00:00 +0100 4647247 Pitfalls in the diagnosis of endometriosis: a condition characterized by a plethora of unusual histological features http://www.medworm.com/index.php?rid=4647245&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231711000132%2Fabstract%3Frss%3Dyes Abstract: The histological diagnosis of endometriosis is usually straightforward. However, for a large number of reasons, there may be diagnostic difficulties. These difficulties may be related to both unusual morphological features in endometriosis and the occurrence of endometriosis at unusual sites. In this review, 10 problematic areas in the histological diagnosis of endometriosis are discussed. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4647245 Mon, 28 Feb 2011 00:00:00 +0100 4647245 Plaque on the arm http://www.medworm.com/index.php?rid=4585129&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001921%2Fabstract%3Frss%3Dyes This article focuses on a case pseudolymphoma secondary to vaccination. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585129 Thu, 27 Jan 2011 00:00:00 +0100 4585129 Molecular pathology of thyroid cancer http://www.medworm.com/index.php?rid=4585127&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001969%2Fabstract%3Frss%3Dyes Abstract: Thyroid cancer is increasing in incidence. Although often indolent and highly curable neoplasms, they may recur, metastasize, or become resistant to radio-iodine therapy. Advances in understanding the molecular mechanisms that lead to the development and progression of these neoplasms provide opportunity for prevention, effective early identification and targeted therapies for management of aggressive cancers. We review the molecular alterations implicated in thyroid cancer initiation and progression, gene expression profiling and microRNA studies, as well as the results of emerging new data from genome-wide association and single-nucleotide polymorphism (SNP) analyses. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585127 Mon, 24 Jan 2011 00:00:00 +0100 4585127 Poorly differentiated thyroid carcinoma: an evolving entity http://www.medworm.com/index.php?rid=4585126&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000191X%2Fabstract%3Frss%3Dyes Abstract: The term Poorly Differentiated Thyroid Carcinoma (PDTC) was first proposed in the early eighties to describe a heterogeneous group of neoplasms, of follicular cell origin, dwelling in an intermediate clinicopathological position between well-differentiated follicular or papillary carcinomas and undifferentiated carcinomas. Over the following two decades defenders and sceptics have sustained an unsurmountable debate pertaining the nature of PDTC, its morphological diagnostic features, its clinical relevance and the most suitable management. In 2004, the WHO Committee on Thyroid Tumours agreed to recognize PDTCs as a distinct entity in thyroid follicular cell tumourigenesis. The proposed diagnostic criteria resulted however difficult to apply on daily practice. Four years ago, in a... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585126 Mon, 24 Jan 2011 00:00:00 +0100 4585126 Mesenchymal neoplasms of the stomach http://www.medworm.com/index.php?rid=4585130&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001970%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585130 Fri, 14 Jan 2011 00:00:00 +0100 4585130 The role of thyroid fine needle aspiration cytology and the Bethesda system for reporting thyroid cytopathology http://www.medworm.com/index.php?rid=4585124&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001945%2Fabstract%3Frss%3Dyes Abstract: Thyroid fine needle aspiration (FNA) is among the most commonly performed non-gynaecologic cytologic procedures and the single most effective tool for guiding the initial management of a patient with a thyroid nodule. Its acceptance as a reliable preoperative test relies on its high sensitivity and specificity. The recently developed Bethesda System for Reporting Thyroid Cytopathology, has advanced the field by promoting a standard reporting terminology for thyroid aspirates. In addition, it allows communication with the referring physician to occur in terms that are unambiguous, reproducible, and clinically helpful. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4585124 Tue, 11 Jan 2011 00:00:00 +0100 4585124 Pathogenesis of age-related macular degeneration http://www.medworm.com/index.php?rid=4365554&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000160X%2Fabstract%3Frss%3Dyes Abstract: This review provides a summary of the pathogenesis of age-related macular degeneration, a disorder that accounts for approximately 50% of registrations for visual impairment or blindness in industrial societies. Early manifestations include focal and diffuse sub-RPE deposits. The later blinding stages of the condition are defined by choroidal neovascularization, where vessels from the choroid extend under the retina or geographic atrophy, where photoreceptors and retinal pigment epithelial cells die. From histology, genetics, cell biology and therapeutics we know much of the pathogenesis of AMD but complete understanding remains elusive. Low grade inflammation including inappropriate activation of complement, abnormalities of extracellular matrix turnover, angiogenesis, lipofusci... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4365554 Sat, 01 Jan 2011 00:00:00 +0100 4365554 Editorial board http://www.medworm.com/index.php?rid=4365552&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000201X%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4365552 Sat, 01 Jan 2011 00:00:00 +0100 4365552 Histopathology and molecular diagnosis of corneal infections http://www.medworm.com/index.php?rid=4365555&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000157X%2Fabstract%3Frss%3Dyes Abstract: Infectious keratitis is an important cause of visual loss worldwide. Clinical diagnosis in the past was often supported only by microbiology and pathology to a lesser extent. Recent advances in the histological and molecular diagnosis of corneal infections have resulted in rapid and accurate diagnosis of the infectious agent. This review will provide an overview of the various corneal infections, with emphasis on histopathologic and molecular diagnosis. This is more so in cases where microbiology, the gold standard for corneal infections, comes out as negative. Thus a cumulative input from clinical, microbiology, histopathology and molecular methods of diagnosis not only helps in treating the patients but also contributes to better understanding of the disease process and paves t... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4365555 Thu, 02 Dec 2010 00:00:00 +0100 4365555 Exchanging information: current United Kingdom developments in the infrastructure to support post-mortem imaging http://www.medworm.com/index.php?rid=4153687&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001404%2Fabstract%3Frss%3Dyes Abstract: Through joint working across the Home Office, Ministry of Justice and Department of Health the United Kingdom (UK) has developed a single programme of research and development in the field of less invasive autopsy, forensic and mass fatality imaging. By supporting research and development within these fields the UK has developed an outline for a national core training programme in this field along with the development of the National Forensic Image Management System (FiMag). This symposium paper is a brief overview of this development. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153687 Thu, 11 Nov 2010 07:26:21 +0100 4153687 Editorial board http://www.medworm.com/index.php?rid=4153679&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001763%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153679 Thu, 11 Nov 2010 07:26:20 +0100 4153679 Recent advances in the molecular diagnosis of paediatric soft tissue sarcomas http://www.medworm.com/index.php?rid=4365556&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001593%2Fabstract%3Frss%3Dyes Abstract: Sarcomas comprise a significant portion of solid tumours diagnosed in children. As they commonly are composed of primitive round or spindled cells, morphologic diagnosis can be difficult, and ancillary studies are often necessary. In recent years, progress has been made in understanding the cytogenetic and molecular changes underlying many of these tumours, and molecular techniques have emerged from strictly being research tools to becoming standard diagnostic tests. Paediatric sarcomas fall into two categories: those with characteristic underlying translocations, and those without. Translocation associated paediatric sarcomas include, but are not limited to alveolar rhabdomyosarcoma, Ewing’s family of tumours, desmoplastic small round cell sarcoma, synovial sarcoma, infantile ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4365556 Mon, 08 Nov 2010 00:00:00 +0100 4365556 Atypical microglandular adenosis presenting as a breast lump http://www.medworm.com/index.php?rid=4365557&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001581%2Fabstract%3Frss%3Dyes We report a case of atypical microglandular adenosis diagnosed in a 78-year-old woman. The typical histological features, differential diagnostic considerations and association with malignancy are discussed. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4365557 Wed, 03 Nov 2010 00:00:00 +0100 4365557 Pathology of vitreoretinal junction biopsies http://www.medworm.com/index.php?rid=4365553&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001611%2Fabstract%3Frss%3Dyes Abstract: Advances in ophthalmic microsurgical techniques have provided surgical options in a variety of disorders that involve the interface between the retina and the vitreous. These conditions include epiretinal membrane, macular hole, macular oedema, vitreomacular traction syndrome and haemorrhage beneath the vitreous surface of the retina (as, for example, may be seen in Valsalva retinopathy and Terson’s syndrome). This review aims to examine some of the histological features of the specimens that may present to the pathologist from this region of the eye and explore how the surgical interventions themselves, or surgical adjuncts, may alter the pathology of the specimens. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4365553 Tue, 02 Nov 2010 00:00:00 +0100 4365553 Unusual neoplasms of the vulva http://www.medworm.com/index.php?rid=4112979&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001234%2Fabstract%3Frss%3Dyes Abstract: Unusual vulvar neoplasms comprise a small minority of general surgical pathology cases. We have limited our discussion to the following four vulvar tumours that were diagnosed at our institution during the past year: extramammary Paget disease; melanoma; granular cell tumour; and epithelioid sarcoma, proximal-type. We hope that the review will be of practical interest to the general surgical pathologist. Pathogenesis, clinical presentation, morphology, differential diagnosis, ancillary studies, prognosis, and treatment will be discussed. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112979 Fri, 29 Oct 2010 21:00:30 +0100 4112979 Premalignant and malignant squamous lesions of the vulva http://www.medworm.com/index.php?rid=4112977&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001210%2Fabstract%3Frss%3Dyes Abstract: Vulvar premalignant squamous lesions include low- and high-grade intraepithelial neoplasias. High-grade lesions include classic (usual) and differentiated (simplex) vulvar intraepithelial neoplasia (VIN). Classic VIN (cVIN), the most common, is related to human papilloma virus (HPV), occurs in younger patients, and is frequently multifocal. Differentiated VIN (dVIN), less common, is related to lichen sclerosus and other chronic vulvar dermatoses, occurs in older women, and is usually unifocal. Terminology schemes for premalignant lesions are reviewed. Invasive squamous cell carcinoma also occurs in two distinct clinicopathologic settings. Most conventional keratinizing squamous cell carcinomas arise from a background of dVIN and comprise the majority of invasive squamous tumours.... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112977 Fri, 29 Oct 2010 21:00:30 +0100 4112977 Editorial board http://www.medworm.com/index.php?rid=4112974&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001659%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112974 Fri, 29 Oct 2010 21:00:29 +0100 4112974 Premalignant and malignant lesions of the vagina http://www.medworm.com/index.php?rid=4112978&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001222%2Fabstract%3Frss%3Dyes Abstract: This paper will review vaginal lesions including the common premalignant and benign lesions as well as the rather rare primary malignant squamous and glandular neoplasms. Risk factors such as human papilloma virus, smoking and diethylstilbestrol exposure as they pertain to the development of premalignant and malignant lesions of the vagina will also be included. Metastatic tumours to the vagina, which comprise the majority of vaginal malignancies, will also be discussed. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112978 Sun, 24 Oct 2010 23:00:00 +0100 4112978 Vulvar inflammatory dermatoses for the non-dermatopathologist: an approach for the practising surgical pathologist http://www.medworm.com/index.php?rid=4112975&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001192%2Fabstract%3Frss%3Dyes Abstract: Recognition of tissue patterns of injury will help the non-dermatopathologist when confronted with biopsies of vulvar inflammatory dermatoses. This paper defines and discusses the most common inflammatory patterns including: spongiosis, psoriasiform, interface and vesiculobullous, providing a brief overview of the clinical, histologic and differential diagnoses of the more common lesions to affect the vulva. Also included are entities with specific predilection for the female gynaecologic tract including Zoon’s vulvitis and Behcet’s disease. A comprehensive review of this topic is beyond the scope of this mini-symposium. However we hope to provide an approach to the diagnosis of vulvar inflammatory dermatitis which will be of practical use to the surgical pathologist. (Source... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112975 Wed, 20 Oct 2010 23:00:00 +0100 4112975 Immunohistochemical differentiation of metastatic tumours http://www.medworm.com/index.php?rid=4153688&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001398%2Fabstract%3Frss%3Dyes Abstract: Immunohistochemistry is a powerful tool for classifying poorly differentiated cancers and metastatic tumours of unknown origin. Many useful immunohistochemistry stains target proteins unique to a particular organ or cell type, and examples of this group include thyroglobulin for thyroid follicular cells, and surfactant proteins for pulmonary type II pneumocytes and Clara cells. These proteins are closely related to the ultimate function of the particular cell type, and they are more likely expressed by well-differentiated tumours but not poorly differentiated ones. Transcription factors generally function to determine the fate of specification and differentiation in precursor cells, and absence of one transcription factor might result in agenesis of the particular organ and tissu... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153688 Tue, 28 Sep 2010 00:00:00 +0100 4153688 The role of computed tomography in adult post-mortem examinations: an overview http://www.medworm.com/index.php?rid=4153681&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001441%2Fabstract%3Frss%3Dyes Abstract: Radiology has been a part of autopsy practice since just after the discovery of X-rays. Today it remains an important investigative tool although the radiological modalities utilized are changing. The role of post-mortem cross-sectional imaging is gaining acceptance across the world in both natural and unnatural death investigation. This symposium paper provides an overview of the history of the introduction of computed tomography into post-mortem practice, the areas where it is currently been used in practice and problems encountered in relation to its use. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153681 Mon, 20 Sep 2010 00:00:00 +0100 4153681 Gestational trophoblastic disease: histopathological diagnosis in the molecular era http://www.medworm.com/index.php?rid=4112980&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001180%2Fabstract%3Frss%3Dyes Abstract: Gestational trophoblastic disease is a heterogeneous group of proliferative disorders of the placental trophoblasts, often with challenging morphology, posing diagnostic problems for the general, even specialty pathologists. In this review we discuss characteristic histological features of complete- and partial hydatidiform moles, with special focus on the diagnosis of hydatidiform moles evacuated at early stage and their mimics. The diagnostic criteria and potential pitfalls in the diagnosis of gestational choriocarcinoma and two rare, unique neoplasms of the intermediate trophoblast – placental site trophoblastic tumour and epithelioid trophoblastic tumour – are presented, along with their differential diagnoses from two tumour-like conditions including exaggerated placenta... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112980 Sun, 19 Sep 2010 23:00:00 +0100 4112980 How to take and process digital images for publication http://www.medworm.com/index.php?rid=3978913&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001039%2Fabstract%3Frss%3Dyes Abstract: The ability to take and process digital images is important in histopathology, cytopathology and pathology-centric research. In particular publishers demand that digital images are presented in a certain format. Since taking, processing and preparing digital images are often in the hands of the researcher, we should know how to handle digital images and prepare them for publication. This paper outlines the basic principles of digital imaging, what defines image resolution and how to prepare digital images for publication. Common pitfalls in preparing digital illustrations are reviewed together with the ethical constraints around the processing of scientific images. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3978913 Sat, 18 Sep 2010 07:34:57 +0100 3978913 Editorial board http://www.medworm.com/index.php?rid=3978909&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001490%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3978909 Sat, 18 Sep 2010 07:34:56 +0100 3978909 Deviant odontogenic tissues http://www.medworm.com/index.php?rid=4112981&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001246%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112981 Wed, 15 Sep 2010 23:00:00 +0100 4112981 High throughput adult cadaver axial imaging: service logistics and requirements http://www.medworm.com/index.php?rid=4153686&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001416%2Fabstract%3Frss%3Dyes Abstract: It remains unknown to date the extent of the potential role of computed tomography (CT) and magnetic resonance imaging (MRI) in autopsy practice in the United Kingdom (UK). If CT and/or MRI were accepted to have a role beyond that already been undertaken within the UK and implemented on a national high throughput scale, what impact would it have upon the National Health System (NHS) where, in the UK, the majority of mortuary facilities and practitioners work? This symposium paper explores the logistics, personnel and facilities that may be required to assist those contemplating developing such a provision of service. The discussion presented is based upon the concept that all cadavers normally subjected to invasive medico-legal (coroner’s) autopsy would be imaged following rece... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153686 Tue, 14 Sep 2010 00:00:00 +0100 4153686 Post-mortem MR and CT imaging in fetuses, newborns and children: an evidenced based approach http://www.medworm.com/index.php?rid=4153685&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001258%2Fabstract%3Frss%3Dyes Abstract: There is insufficient evidence in the published literature to support the use of post-mortem MR imaging (MRI) as an alternative for conventional non-forensic autopsy in fetuses, newborns and children. Large prospective studies evaluating the accuracy of post-mortem MR imaging in a rigorous and blinded way are now nearing completion and the results are expected in 2011. Less-invasive autopsies by post-mortem MR imaging may have major effect in resurrecting consented autopsy rates; however an evidenced based and systematic approach towards less-invasive autopsy process is mandatory to ensure that the post-mortem data remains accurate and credible. Here we summarize the current evidence, ongoing research and future directions for less-invasive autopsy process in the United Kingdom. ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153685 Tue, 14 Sep 2010 00:00:00 +0100 4153685 The role of computed tomography and magnetic resonance imaging in the investigation of natural death http://www.medworm.com/index.php?rid=4153684&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001428%2Fabstract%3Frss%3Dyes Abstract: Public distaste for the traditional autopsy combined with disquiet about the variable quality of the coroner’s post-mortem have led to increasing pressure to find a less invasive alternative. There have been previous studies using computed tomography (CT) and magnetic resonance imaging (MRI) to determine cause of death but there is very little evidence of the accuracy or reproducibility of these techniques in non-forensic cases. In 2006 the Department of Health funded a validation study of post-mortem imaging in adults which is due to report this year. Preliminary results suggest that, if a confident imaging (MR and CT) diagnosis of the cause of death is made, the major error rate is close to that of clinical death certificates. There are major weaknesses in diagnosis of corona... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153684 Tue, 14 Sep 2010 00:00:00 +0100 4153684 Editorial http://www.medworm.com/index.php?rid=4153680&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001386%2Fabstract%3Frss%3Dyes If one reads reviews concerning the history of autopsy practice such as that authored by Burton it becomes clear that little has changed in autopsy practice over hundreds of years. The cycle of public revulsion through to fascination and the role of the autopsy in man’s understanding of human anatomy and understanding of pathological processes of disease has gone full circle. Today the quest for an alternative to the current invasive autopsy is at an all time high, both from the public, religious faiths, governments and the medical practitioners themselves. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153680 Tue, 14 Sep 2010 00:00:00 +0100 4153680 Initiating a post-mortem computed tomography service: the radiologist’s perspective http://www.medworm.com/index.php?rid=4153683&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000143X%2Fabstract%3Frss%3Dyes Abstract: Many radiologists have extensive clinical Computed Tomography (CT) experience that is useful for post-mortem scanning; but there are some differences in approach. Firstly clinical scan protocols optimize diagnostic information whilst keeping radiation dose low. This is not an issue for post-mortem scanning, but X-ray tube heat loading and difficulty in handling thousands of images can require similar compromises. Knowledge of normal post-mortem changes that can simulate disease is required for image reporting. Our practice is to use CT as an adjunct to the autopsy. It is therefore important to know what information is useful to the pathologist prior to the autopsy and what areas may be easily visible to imaging but not the pathologist. When reporting post-mortem scans there may b... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153683 Fri, 10 Sep 2010 00:00:00 +0100 4153683 Benign vulvovaginal cysts http://www.medworm.com/index.php?rid=4112976&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001209%2Fabstract%3Frss%3Dyes This article discusses the common benign cysts found in the vagina and vulva. While not commonly encountered in routine surgical pathology practice, these cysts are a relatively frequent occurrence. The cysts are often asymptomatic and do not come to clinical attention. Cysts of the vagina and vulva can be classified as embryologic or non-embryologic in origin, with müllerian and mesonephric cysts being the most common embryologic cysts. A discussion of the embryologic origin of the vagina and vulva is included as this knowledge can help in accurately characterizing cystic lesions found in this location. Non-embryologic cysts include endometriosis, inclusion cysts, and other rare lesions. These entities are discussed to allow distinction from cysts of embryologic origin. With accurate cli... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4112976 Thu, 09 Sep 2010 23:00:00 +0100 4112976 An image of sudden death: utility of routine post-mortem computed tomography scanning in medico-legal autopsy practice http://www.medworm.com/index.php?rid=4153682&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000126X%2Fabstract%3Frss%3Dyes Abstract: Post-mortem computed tomography (CT) is an established technique at Victorian Institute of Forensic Medicine (VIFM) used to assist pathologists in determining cause and manner of death. It also plays an important role in identification of deceased individuals as exemplified by the 2009 “Black Saturday” Victorian bushfires in which the remains of 164 individuals were subjected to disaster victim identification procedures. CT scanning is now explicitly incorporated into the Victorian Coronial legislation (Coroners Act 2008), and is an important component of the preliminary examination process whereby a pathologist reviews the circumstances of a death, any pre-existing medical history, whole body CT images, the external appearances of the body and expedited (overnight) toxicolog... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=4153682 Mon, 06 Sep 2010 00:00:00 +0100 4153682 The use of immunohistochemistry in the differential diagnosis of primary cutaneous adnexal neoplasms and metastatic adenocarcinomas to the skin http://www.medworm.com/index.php?rid=3918110&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001179%2Fabstract%3Frss%3Dyes This article reviews the use of immunohistochemistry as an adjunctive tool in the analysis of primary and metastatic carcinomas involving the skin. It also provides an algorithm including selected markers that can be used in this context. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3918110 Tue, 31 Aug 2010 23:00:00 +0100 3918110 Editorial board http://www.medworm.com/index.php?rid=3918108&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001325%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3918108 Tue, 31 Aug 2010 23:00:00 +0100 3918108 Mesenteric solitary fibrous tumour containing metastasis from breast carcinoma: an unusual example of tumour to tumour metastasis http://www.medworm.com/index.php?rid=3797018&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000940%2Fabstract%3Frss%3Dyes Abstract: Tumour to tumour metastasis is a relatively rare but well documented phenomenon. The most frequent donor tumour is lung carcinoma, and renal cell carcinoma is by far the most common recipient. Here we present a case of a 46-year-old man operated for a mesenteric tumour, which showed histological and immunohistochemical features of a solitary fibrous tumour. However, on section contained a 3.5 mm focus of an epithelial component. After a search in the past medical records it was known that the patient had been operated 3 years earlier for breast carcinoma. The epithelial component in the present tumour showed similar histological and immunohistochemical features. This is the first example of a tumour to tumour metastasis where breast carcinoma has metastasized to mesenteric solita... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797018 Thu, 29 Jul 2010 06:47:22 +0100 3797018 Editorial board http://www.medworm.com/index.php?rid=3797011&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001088%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797011 Thu, 29 Jul 2010 06:47:22 +0100 3797011 Diverse facets of cervical adenocarcinoma: comprehensive review of clinicopathologic features and diagnostic criteria http://www.medworm.com/index.php?rid=3978911&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001015%2Fabstract%3Frss%3Dyes Abstract: Cervical adenocarcinomas span a diverse group of tumours in terms of their pathogenesis, morphology and patients’ prognosis. The diagnostic challenges are numerous and arise with virtually every case. The issues that may be particularly difficult in histopathologic evaluation of cervical adenocarcinomas include 1) differentiating in-situ and invasive tumours from their benign mimics, 2) differentiating adenocarcinoma in-situ from an early invasive lesion, 3) measuring the depth of invasion, 4) differentiating primary cervical adenocarcinoma from uterine endometrial adenocarcinoma or tumours metastatic from other primary sites such as colon. The paper reviews the pathogenesis, clinical characteristics, diagnostic criteria, immunohistochemical markers, differential diagnosis and ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3978911 Sun, 25 Jul 2010 23:00:00 +0100 3978911 Molecular markers of early cervical neoplasia http://www.medworm.com/index.php?rid=3978910&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001003%2Fabstract%3Frss%3Dyes Abstract: Pure morphological distinction of high-grade squamous intraepithelial lesions (HSILs) from their mimics can be challenging. Diagnosis can be difficult with nonconventional HSILs associated with a metaplastic phenotype, squamous intraepithelial lesions (SILs) that defy precise classification such as “eosinophilic dysplasias”, and those that overlap with columnar neoplasms, including stratified variants of adenocarcinoma in situ (“SMILE”). Gene expression and protein profiling have identified biomarkers with the potential to decrease diagnostic variability and increase specificity of histological and cytological analysis. Among the ones clinically useful for HSIL detection are p16INK4A and MIB-1 which complement each other, differentiating SIL from normal/atrophic (MIB-1 lo... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3978910 Thu, 22 Jul 2010 23:00:00 +0100 3978910 IgG4-related disease – a modern mimic of malignancy http://www.medworm.com/index.php?rid=3978914&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001040%2Fabstract%3Frss%3Dyes We report four cases of IgG4-related disease which presented as clinical mimics of malignancy in different anatomical sites and were correctly diagnosed by histopathology. Appropriate clinico-pathological suspicion combined with immunohistochemistry and serology can establish the correct diagnosis. IgG4-related disease appears to respond well to systemic steroid therapy irrespective of the organ of origin and this emphasizes the clinical importance of distinguishing between IgG4-related disease and other non-related sclerosing disorders. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3978914 Thu, 15 Jul 2010 23:00:00 +0100 3978914 Pseudoneoplastic lesions of the uterine cervix http://www.medworm.com/index.php?rid=3978912&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710001027%2Fabstract%3Frss%3Dyes This article reviews benign entities that may be mistaken for neoplastic lesions of the cervix. Conditions of the ectocervical squamous epithelium, the endocervical glandular epithelium and the cervical stroma are systematically discussed in the context of the respective (pre)malignant lesion that they may be confused with, including low and high-grade squamous intraepithelial lesions, invasive squamous cell carcinoma, adenocarcinoma in-situ, various types of invasive adenocarcinomas, and sarcomas. Emphasis is placed on those features that help distinguish pseudoneoplastic lesions from true neoplasms, including clinical information, morphologic findings and ancillary studies. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3978912 Thu, 15 Jul 2010 23:00:00 +0100 3978912 Unusual patterns of cutaneous sebaceous neoplasms http://www.medworm.com/index.php?rid=3918112&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000976%2Fabstract%3Frss%3Dyes Abstract: This review discusses unusual and rare microscopic images that may be observed in cutaneous sebaceous neoplasms, including labyrinthine–sinusoidal, ‘rippled’ and carcinoid-like growth patterns. Other unusual features that may be diagnostically problematic are considered, along with ectopic sebaceous lesions and cutaneous-type sebaceous neoplasms arising outside the skin. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3918112 Wed, 14 Jul 2010 23:00:00 +0100 3918112 Atypical fibroxanthoma: differential diagnosis from other sarcomatoid skin lesions http://www.medworm.com/index.php?rid=3918109&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000952%2Fabstract%3Frss%3Dyes Abstract: Atypical fibroxanthoma (AFX) is an uncommon cutaneous neoplasm that usually presents as a rapidly-growing nodule in sun-exposed sites in elderly patients. Despite its highly atypical histological appearance it is almost always associated with innocuous clinical behaviour. AFX is now generally regarded as the superficial counterpart of undifferentiated pleomorphic sarcoma (so-called malignant fibrous histiocytoma [MFH]). The former lesion is associated with an excellent prognosis in view of its small size, superficial location, and amenability to complete excision. Because a distinction between AFX and MFH requires assessment of the depth of invasion, a definitive diagnosis of AFX cannot be made on the basis of shallow biopsies. Other cutaneous tumours, including sarcomatoid squam... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3918109 Sun, 11 Jul 2010 23:00:00 +0100 3918109 Prostate pathology http://www.medworm.com/index.php?rid=3918114&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000099X%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3918114 Thu, 08 Jul 2010 23:00:00 +0100 3918114 Non-neoplastic diseases of the intra- and extrahepatic bile ducts http://www.medworm.com/index.php?rid=3797016&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000927%2Fabstract%3Frss%3Dyes Abstract: Non-neoplastic diseases of the intra- and extrahepatic bile ducts are collectively called “cholangiopathies”, in which biliary epithelial cells or cholangiocytes are the primary target of the disease process. The spectrum of cholangiopathies ranges from acquired conditions due to disordered immunity, infections, ischaemia, drugs/toxins to congenital disorders of the intra- and extrahepatic bile ducts. The diagnosis of these diseases is best made through consideration of the possible differential diagnoses, familiarity with the histologic patterns of injury and a correlation with the clinical setting. This review will provide an insight into the non-neoplastic biliary pathology with an overview of the various patterns of bile-duct injury and emphasis on clinico-pathologic corr... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797016 Thu, 08 Jul 2010 23:00:00 +0100 3797016 Staging prostate cancer and its relationship to prognosis http://www.medworm.com/index.php?rid=3918113&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000988%2Fabstract%3Frss%3Dyes The objective of staging is to group malignancies with similar prognosis and therapeutical approach, to be able to compare clinicopathologic data from different institutions, and to perform clinical trials or research studies on a homogeneous population of patients.Accurate pathology staging for prostate cancer is critical to determine treatment of individual patients and it reflects ultimate expected clinical outcome. Radical prostatectomy Gleason score, pathologic T stage, lymph node and surgical margin status are independent predictors of biochemical recurrence-free survival.The TNM staging system is the most widely used system for prostate cancer staging, assessing the extent of primary tumor, the absence or presence of regional lymph node involvement, and the absence or presence of di... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3918113 Sun, 04 Jul 2010 23:00:00 +0100 3918113 Cutaneous lymphoid proliferations: a clinicopathological continuum? http://www.medworm.com/index.php?rid=3918111&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000964%2Fabstract%3Frss%3Dyes Abstract: The distinction of cutaneous lymphomas from inflammatory dermatoses is considered to be one of the most vexing problems in diagnostic dermatopathology. Identification of “clonal dermatoses” which, in some instances, evolve into overt lymphomas, has prompted the suggestion that cutaneous lymphoid hyperplasia may represent a continuum with lymphomatous potential. Some of the difficulties that we encounter in the diagnosis of cutaneous lymphomas are, however, conceptual. That is because diagnostic criteria for the earliest stages of malignant tumours impinge on the “grey zone” between what is clearly benign and what is obviously malignant. On the other hand, a pragmatic approach to the management of patients with “borderline” lymphoproliferative disorders seems to be the... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3918111 Sun, 04 Jul 2010 23:00:00 +0100 3918111 Benign tumors and tumor-like lesions of the gallbladder and extrahepatic biliary tract http://www.medworm.com/index.php?rid=3797015&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000897%2Fabstract%3Frss%3Dyes Abstract: The gallbladder is one of the most common specimens encountered in surgical pathology laboratories worldwide. A vast majority of these show merely cholelithiasis and chronic cholecystitis, however, a wide variety of benign tumors and tumor-like lesions can occur in the gallbladder and are largely discovered incidentally. Benign tumors of the gallbladder and extrahepatic bile ducts are similar, however, the incidences vary by site. The epithelial tumors include adenomas that can be gastric, intestinal or biliary types, and cystadenomas. Mesenchymal tumors are even more rare and identical to their soft tissue counterparts. Of these as a group, the neurogenic lesions are most common. The tumor-like lesions include various types of metaplasia, hyperplasia, heterotopia and chronic cho... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797015 Sun, 04 Jul 2010 23:00:00 +0100 3797015 Malignant tumours of gallbladder and extrahepatic bile ducts http://www.medworm.com/index.php?rid=3797014&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000915%2Fabstract%3Frss%3Dyes Abstract: Biliary tract neoplasms are divided into cancers of the gallbladder (GB) and intrahepatic and extrahepatic bile ducts (EBD). GB and EBD tumours are closely related, although they show marked differences in epidemiology, aetiology and clinical presentation. GB neoplasms are uncommon in North America but endemic in South America and Asia, whereas EBD tumours show no geographic predilection. Both gallbladder cancer (GBC) and extrahepatic bile duct cancer (EBDC) present at an advanced stage, and are associated with an aggressive course and poor prognosis. These tumours occur primarily in older patients and are strongly associated with chronic inflammation of the biliary epithelium. GBC is more common in women while EBDC is slightly more common in men. Over 90% are carcinomas, usually... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797014 Thu, 01 Jul 2010 23:00:00 +0100 3797014 Non-neoplastic diseases of the gallbladder http://www.medworm.com/index.php?rid=3797013&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000903%2Fabstract%3Frss%3Dyes Abstract: Cholecystitis is the most prevalent surgical disease of industrialized countries, and usually results from cholelithiasis. More than 20,000,000 people in the United States have gallstones, 40% of whom will require surgical intervention. Although assessing gallbladder specimens is generally straightforward, enhanced detection of asymptomatic gallstones, incidental cholecystectomy, and improved diagnostic criteria for systemic illnesses account for an increasing number of cholecystectomy specimens that lack typical features of gallstone-related disease. A spectrum of immune-mediated disorders and infections may also be observed in gallbladder specimens. The purpose of this review is to discuss the manifestations of gallstone-related gallbladder injury, and different types of acalcu... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797013 Tue, 29 Jun 2010 23:00:00 +0100 3797013 Fibrolamellar hepatocellular carcinoma http://www.medworm.com/index.php?rid=3797017&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000939%2Fabstract%3Frss%3Dyes Abstract: Fibrolamellar hepatocellular carcinoma (FLM) is a rare tumour that typically presents in young adults. It occurs in non-cirrhotic liver and is usually associated with normal serum alpha-fetoprotein. It is defined by a triad of morphological features: polygonal tumour cells with eosinophilic cytoplasm, prominent macronucleoli and lamellar fibrosis. A central scar can be present. The principal differential diagnosis is conventional hepatocellular carcinoma (HCC), especially the scirrhous variant. Acinar differentiation and focal mucin production are common and can be confused with adenocarcinoma. Focal neuroendocrine differentiation can occur and can be mistaken for neuroendocrine tumours. FLM also shows distinctive features at the molecular level; many of the commonly observed abn... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797017 Sun, 27 Jun 2010 23:00:00 +0100 3797017 Introduction http://www.medworm.com/index.php?rid=3797012&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000563%2Fabstract%3Frss%3Dyes Disorders of the biliary tract have a high prevalence worldwide. In the United States, approximately 600,000 cholecystectomies are performed annually of which over 95% are due to cholelithiasis (gallstones) and its complications. It is therefore not surprising that gallbladders are amongst the most frequently encountered surgical specimens in routine pathology practice. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3797012 Sun, 20 Jun 2010 23:00:00 +0100 3797012 Editorial board http://www.medworm.com/index.php?rid=3646685&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000800%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3646685 Thu, 10 Jun 2010 14:06:05 +0100 3646685 Fine needle aspiration cytology of head and neck diseases: advantages and limitations http://www.medworm.com/index.php?rid=3593865&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000484%2Fabstract%3Frss%3Dyes Abstract: Fine needle aspiration cytology is a valuable technique in the diagnostic assessment and management of patients with head and neck lesions. Combining the technique with ultrasound examination allows both the clinical assessment and confidence in appropriate cytological sampling to be enhanced. Inadequate sample rates may be reduced to about 5% or less. The multidisciplinary team approach optimizes the use of available information, and lack of correlation between clinical, imaging and cytological findings may be reviewed critically before treatment of the patient. Concordant findings may guide appropriate management and avoid unnecessary tests. The cytological diagnosis of many head and neck lesions may be made with a high degree of accuracy, but awareness of the diagnostic pitfal... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3593865 Tue, 25 May 2010 14:02:17 +0100 3593865 Editorial board http://www.medworm.com/index.php?rid=3593861&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000708%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3593861 Tue, 25 May 2010 14:02:17 +0100 3593861 Genetic alterations in malignant melanoma http://www.medworm.com/index.php?rid=3646687&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000393%2Fabstract%3Frss%3Dyes Abstract: Many advances in the understanding of the genetic and cellular events that drive melanoma formation have occurred in the last decade. Despite intensive efforts to develop melanoma therapies, no approved melanoma therapy significantly increases overall survival of advanced-stage patients. An awareness of the genetic alterations that occur in melanoma will be critical in order to facilitate the development of effective individualized melanoma therapies. This understanding may also aid the discovery of molecular biomarkers that refine histopathological determinants of prognosis and melanoma diagnosis. In this article, we review a brief background on melanoma epidemiology and what is currently known about common genetic alterations found in sporadic and inherited melanoma as well as ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3646687 Mon, 03 May 2010 23:00:00 +0100 3646687 Unusual variants of cutaneous melanoma http://www.medworm.com/index.php?rid=3646688&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000526%2Fabstract%3Frss%3Dyes Abstract: Melanomas possess a remarkable capacity for morphological diversity and even divergent differentiation. Classification of these unusual variants is based on the recognition of a specific growth pattern (e.g. pseudoglandular, angiomatoid) or a unique cytological attribute (e.g. clear cell, balloon cell, rhabdoid). Unusual morphology may be encountered in primary, metastatic or recurrent tumours alike. Some variants are so named because of their ability to mimic benign melanocytic proliferations (e.g. naevoid, Spitzoid). Most are not associated with specific prognostic differences. Instead, their importance resides in the potential for confusion with a wide range of benign and malignant neoplasms. Diagnosis of melanoma is less problematic when lesions are pigmented and/or if there ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3646688 Thu, 29 Apr 2010 23:00:00 +0100 3646688 Melanocytic naevi of special sites http://www.medworm.com/index.php?rid=3646686&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000514%2Fabstract%3Frss%3Dyes Abstract: There is a recently recognized and relatively common group of melanocytic naevi that share histopathologic features in common with dysplastic naevi and malignant melanoma. These naevi have been termed “naevi of special sites” or “naevi with site-related atypia” as distinctive features have been correlated with specific anatomic sites. The list of sites attributed with bearing such naevi is expanding and includes genitals, acral locations, flexural areas, breast, scalp, auricular regions, and conjunctiva. Despite the atypical histopathologic features, the vast majority of these lesions are benign and do not appear to have an increased risk for progression to malignancy. As authentic dysplastic naevi and melanoma may also occur at these sites, it is important for practicing... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3646686 Thu, 29 Apr 2010 23:00:00 +0100 3646686 Selected recent advances in the pathology of salivary neoplasms http://www.medworm.com/index.php?rid=3593864&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000459%2Fabstract%3Frss%3Dyes Abstract: This review concentrates on significant developments in salivary pathology since the 2005 WHO classification was written. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3593864 Tue, 27 Apr 2010 23:00:00 +0100 3593864 Lobular neoplasia http://www.medworm.com/index.php?rid=3646690&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623171000054X%2Fabstract%3Frss%3Dyes Abstract: Although pathologists have recognized the classic forms of lobular neoplasia for decades, our understanding of this disease has changed markedly since its first description. The term lobular neoplasia encompasses a spectrum of entities ranging from atypical lobular hyperplasia to more recently recognized lobular carcinoma in situ (LCIS) variants including LCIS with necrosis and pleomorphic LCIS. Along with an expanded definition of lobular neoplasia, our concept of the pathobiologic potential of these lesions has evolved. While lobular neoplasia has been viewed primarily as a risk marker of invasive breast carcinoma since the late 1970s, there is increasing evidence that they are also non-obligate precursors. In this review, we will address the history of the disease, updated con... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3646690 Sun, 25 Apr 2010 23:00:00 +0100 3646690 Teratoma differentiated with predominant cartilaginous differentiation http://www.medworm.com/index.php?rid=3593867&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000502%2Fabstract%3Frss%3Dyes We present a case of monodermal teratoma differentiated tumour with almost exclusive cartilaginous differentiation. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3593867 Sun, 25 Apr 2010 23:00:00 +0100 3593867 Lymph node metastases in head and neck malignancies: assessment in practice and prognostic importance http://www.medworm.com/index.php?rid=3593863&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000472%2Fabstract%3Frss%3Dyes Abstract: The assessment of neck dissections is an important part of the routine workload of head and neck histopathology. This review provides practical guidance on the macroscopic and microscopic features of importance and discusses potential diagnostic difficulties and pitfalls. The prognostic value of detailed pathological staging is reviewed and controversial topics that may arise in multidisciplinary team meetings are discussed. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3593863 Sun, 25 Apr 2010 23:00:00 +0100 3593863 Prognostic parameters of malignant melanoma http://www.medworm.com/index.php?rid=3646689&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000538%2Fabstract%3Frss%3Dyes This article will review the major prognostic parameters that the practicing pathologist is expected to evaluate in the routine workup of primary cutaneous melanomas. Emphasis is placed on practical aspects and histologic criteria. (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3646689 Thu, 22 Apr 2010 23:00:00 +0100 3646689 Renal transplant pathology http://www.medworm.com/index.php?rid=3646691&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000551%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3646691 Wed, 21 Apr 2010 23:00:00 +0100 3646691 The biological significance of lymphangiogenesis in human tumours http://www.medworm.com/index.php?rid=3593866&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000496%2Fabstract%3Frss%3Dyes Abstract: Increasing evidence indicates that lymphangiogenesis in cancer is an important factor in promoting tumour progression and metastasis. The discovery of immunohistochemical markers for lymphatic vessels' identification as well as the characterization of lymphatic-specific growth factors and receptors afforded insight into the mechanisms involved in new lymphatic vessel formation and the process of lymphatic-borne metastasis. Quantitative assessment of lymphangiogenesis in malignant tumours has emerged as a promising prognostic indicator, although there are conflicting results on the impact of lymphatic vessel density to predict lymph nodal metastases and overall survival. Solid tumours were recently found to induce new lymphatic vessel growth in draining lymph nodes before the onse... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3593866 Wed, 21 Apr 2010 23:00:00 +0100 3593866 Inflammatory diseases of the nasal cavities and paranasal sinuses http://www.medworm.com/index.php?rid=3593862&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000460%2Fabstract%3Frss%3Dyes Abstract: Inflammatory diseases of the nose and paranasal sinus are commonly encountered in diagnostic histopathology. This review describes the possible manifestations of the common diseases as well as highlighting some of the uncommon causes of sinonasal inflammation which may have importance for treatment and prognosis. The diagnosis of fungal sinusitis is primarily histological. It is important to distinguish between invasive and non-invasive fungal sinusitis, the latter including allergic fungal sinusitis characterized by ‘allergic mucin’ and scanty fungal hyphae. Nasal eosinophilia is a feature of both allergic and non-allergic rhinosinusitis and a wide range of secondary changes in inflammatory polyps may lead to diagnostic confusion. Nasal biopsies are often taken from perforat... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3593862 Wed, 21 Apr 2010 23:00:00 +0100 3593862 Editorial board http://www.medworm.com/index.php?rid=3356764&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000319%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3356764 Fri, 12 Mar 2010 15:11:02 +0100 3356764 Lymphomas involving the spleen http://www.medworm.com/index.php?rid=3329329&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS175623170900228X%2Fabstract%3Frss%3Dyes Abstract: Splenectomy is undertaken for diagnosis, and in later stages of management, of patients with a diverse range of lymphomas. High quality histological sections, requiring careful attention to tissue fixation, are needed to assess these lesions adequately. Increasing use of fine-needle aspiration, needle core biopsy and laparoscopic surgery add further diagnostic challenges. In addition to involvement by dissemination of lymphomas based primarily in lymph nodes, bone marrow or other tissues, spleen is the predominant site of disease in several distinctive types of lymphoma. In particular, splenic marginal zone B-cell lymphoma, hairy cell leukaemia and T-cell and macrophage-rich large B-cell lymphoma are recognized as clinicopathologically distinct entities. Research into the cellula... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3329329 Mon, 01 Mar 2010 00:00:00 +0100 3329329 Editorial board http://www.medworm.com/index.php?rid=3329327&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231710000228%2Fabstract%3Frss%3Dyes (Source: Diagnostic Histopathology) Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3329327 Mon, 01 Mar 2010 00:00:00 +0100 3329327 Lymphoproliferative disorders in the immunosuppressed http://www.medworm.com/index.php?rid=3356768&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231709002357%2Fabstract%3Frss%3Dyes Abstract: Lymphoproliferative disorders occur at a higher frequency in immunosuppressed patients than in the general population and these are a group of diseases that range from benign lymphoid proliferations to full-blown lymphomas. These proliferations develop as a consequence of immunosuppression. Their histological appearances and immunophenotypic features are varied. While some resemble lymphoid lesions seen in immune competent patients, others have unique characteristics, with some posing diagnostic problems. Furthermore, within some clinical contexts like the post-transplant setting, the distinction between benign and malignant proliferations is blurred. Identification of specific entities requires a clear understanding of clinical context and morphology, together with a wide immuno... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3356768 Thu, 25 Feb 2010 00:00:00 +0100 3356768 Lymphomas in the bone marrow http://www.medworm.com/index.php?rid=3329330&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231709002291%2Fabstract%3Frss%3Dyes Abstract: Lymphomatous infiltrates are most commonly encountered in a bone marrow biopsy (BMB) taken for lymphoma staging or for diagnosis of a suspected haematological abnormality. Crucial for staging, the BMB may show classic and variant patterns of lymphomatous infiltration and immunoprofile. Exceptions to the common profiles may be associated with variant cytogenetics and have prognostic implications. Diagnosis should be multifaceted and flow cytometry and molecular studies may be required to arrive at a final diagnosis. Assessment of haematopoiesis should be included in all reports.In follow-up biopsies, disease bulk may be markedly reduced and reactive lymphoid proliferation may complicate the morphological assessment. Transformation of the original lymphoma to a higher grade or the ... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3329330 Mon, 15 Feb 2010 00:00:00 +0100 3329330 Primary cutaneous lymphoma: An overview based on the WHO–EORTC classification http://www.medworm.com/index.php?rid=3356766&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231709002333%2Fabstract%3Frss%3Dyes Abstract: Primary cutaneous lymphomas, defined by their presentation in the skin in the absence of extracutaneous disease at diagnosis, are a heterogenous group of T- and B-cell neoplasms. The commonest, mycosis fungoides, has no nodal counterpart but others show morphological, immunophenotypic and genotypic similarities to primary extracutaneous lymphomas and yet display very different clinical behaviour. This review discusses the salient features of the major entities in the context of the recent World Health Organization/European Organization for the Research and Treatment of Cancer (WHO/EORTC) classification of primary cutaneous lymphoma. In particular, it emphasizes the importance of close clinicopathological correlation and detailed immunophenotyping in their diagnosis. (Source: Diag... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3356766 Mon, 08 Feb 2010 00:00:00 +0100 3356766 Nodal B-cell lymphoma and Hodgkin lymphoma: current WHO classification and differential diagnostic dilemmas http://www.medworm.com/index.php?rid=3285976&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231709002229%2Fabstract%3Frss%3Dyes Abstract: Normal B cells undergo an apparently complex series of morphological phenotypic and molecular changes as part of their transformation from lymphoblasts to plasma cells. Understanding this pathway is the key to understanding the classification of lymphoma. The molecular changes underlying classical and nodular lymphocyte predominant Hodgkin lymphoma help us orientate these diseases with respect to normal B-cell development. This knowledge does not equate with a cellular origin for each tumour but helps us understand the relationship between morphology, phenotype, genotype and the clinical course of the disease. After the introduction of B-cell development, this article describes the nodal B-cell lymphomas, details the associated phenotype and genotype and documents the most import... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3285976 Mon, 08 Feb 2010 00:00:00 +0100 3285976 Editorial http://www.medworm.com/index.php?rid=3329328&cid=s_38397_32_f&fid=38397&url=http%3A%2F%2Fwww.diagnostichistopathology.co.uk%2Farticle%2FPIIS1756231709002321%2Fabstract%3Frss%3Dyes In the February 2010 issue of Diagnostic Histopathology we concentrated on lymphomas in nodal and extranodal sites. While the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues includes descriptions of manifestations of these neoplasms in the blood and bone marrow, the bone marrow biopsy (BMB) receives less emphasis, particularly in lymphoid lesions. Routine trephine biopsy of the bone marrow as a diagnostic tool is relatively recent, dating from 1958. The BMB requires decalcification prior to conventional processing and the optimum method to obtain the best compromise between speed of processing and morphology and, more recently, suitability for molecular diagnostic techniques, has not yet been resolved. Both resin embedding and paraffin embedding have had their adv... Diagnostic Histopathology journals http://www.medworm.com/rss/comments.php?id=3329328 Mon, 01 Feb 2010 00:00:00 +0100 3329328