MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diagnostic Pathology' source. Thu, 09 Feb 2012 00:42:11 +0100 http://www.medworm.com/index.php?rid=5669164&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F15 ObjectiveTo verify the efficacy of ImageJ 1.43n in determining the extent of apoptosis which is a complex and multistep process.Study Design: Cisplatin in different concentrations was used to induce apoptosis in cultured Hep2 cells. Cell viability assay and nuclear image analysis of stained Hep2 cells were used to discriminate apoptotic cells and cells suspected of undergoing apoptosis from control cells based on parameters such as nuclear area, circularity, perimeter and nuclear area factor (NAF), in association with visual morphology. Results: Image analysis revealed a progressive and highly significant decrease in nuclear area factor detected in apoptotic cells and in cells suspected of undergoing apoptosis compared to the control cells (P-values (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5669164 Mon, 06 Feb 2012 05:00:00 +0100 5669164 http://www.medworm.com/index.php?rid=5651041&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F14 Conclusion: Evaluation of CD10 and Ki67 status together with conventional histological evaluation can help in providing more information about the biologic behavior of the tumor, while EGFR could be a target of an expanding class of anticancer therapies.Since ameloblastomas are EGFR-positive tumors, anti-EGFR agents could be considered to reduce the size of large tumors and to treat unresectable tumors that are in close proximity to vital structures. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5651041 Thu, 02 Feb 2012 05:00:00 +0100 5651041 http://www.medworm.com/index.php?rid=5651042&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F13 Two studies recently reported around 10% of EGFR activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the EGFR mutation profiles seem to be related to the ethnical origin of patients. This is an important point that should be considered when developing anti-EGFR therapies. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5651042 Wed, 01 Feb 2012 05:00:00 +0100 5651042 http://www.medworm.com/index.php?rid=5651043&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F12 In conclusion, we demonstrate that CD163 staining is lower than CD68, with less non-specific staining of background inflammatory cells and Hodgkin cells, therefore is a better marker for tumor associated macrophages. However, we did not identify a correlation between staining for CD68 or CD163 and recurrence of disease.Virtual slidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1460518258831620 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5651043 Mon, 30 Jan 2012 05:00:00 +0100 5651043 http://www.medworm.com/index.php?rid=5651044&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F11 Conclusion: MRI is required to orient the diagnosis of MLD patients; the latter must be confirmed by the biochemical investigations which is based on the measurement of ASA activity and the excess of sulfatide showed in the sulfatiduria.Virtual slides:The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1791578262610232 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5651044 Sat, 28 Jan 2012 05:00:00 +0100 5651044 http://www.medworm.com/index.php?rid=5651045&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F10 Conclusions: Clinical history and a high index of suspicion are prerequisite to detecting GBC. Detection of GBC at an early stage is difficult because the symptoms mimic benign gallbladder diseases. Misinterpretation of subtle microscopic abnormalities contributes diagnostic failures in early cases. Careful attention to any evidence of mural thickening, thorough sampling, particularly in older patients, and close examination of any deeply situated glandular structures are critical. Correlations with radiographic and clinical findings are important helps to avoid misdiagnosis in this commonly resected organ. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5651045 Fri, 27 Jan 2012 05:00:00 +0100 5651045 http://www.medworm.com/index.php?rid=5621578&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F9 Conclusions: Both the CK7/CK20+ phenotype and expression of the antibody CDX2 are highly specific and sensitive markers of colorectal origin. CDX2 expression should be a useful adjunct for the diagnosis of intestinal adenocarcinomas, particularly when better established markers such as CK7 and CK20 yield equivocal results. The CK7/CK20+ phenotype is superior in its specificity and positive predictive value and might be preferred.Virtual slides:The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/4851011866354821 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5621578 Mon, 23 Jan 2012 05:00:00 +0100 5621578 http://www.medworm.com/index.php?rid=5611957&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F8 Conclusion: This study has provided further evidence that the histological transformation and progression of gliomas may be associated with the inactivation of the EGFR and MGMT genes. It seems that EGFR and MGMT promoter hypermethylations are early events in the clonal evolution of gliomas and this gene inactivation has proved to be stable even in tumour recurrence. However, the DNMT hypermethylation is a late part of glioma progression.Virtual slides: The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1935054011612460 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5611957 Fri, 20 Jan 2012 05:00:00 +0100 5611957 http://www.medworm.com/index.php?rid=5611958&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F7 We report a case of AITL of which secondary cutaneous EBV-associated diffuse large B-cell lymphoma (DLBCL) developed after the initial diagnosis of AITL. A 65-year-old Chinese male patient was diagnosed as AITL based on typical histological and immunohistochemical characteristics in biopsy of the enlarged right inguinal lymph nodes. The patient initially received 6 cycles of chemotherapy with CHOP regimen (cyclophosphamide, vincristine, adriamycin, prednisone), but his symptoms did not disappear. Nineteen months after initial diagnosis of AITL, the patient was hospitalized again because of multiple plaques and nodules on the skin. The skin biopsy was performed, but this time the tumor was composed of large, polymorphous population of lymphocytes with CD20 and CD79a positive on immunohistoc... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5611958 Thu, 19 Jan 2012 05:00:00 +0100 5611958 http://www.medworm.com/index.php?rid=5599902&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F6 Cystic change in metastatic lymph nodes occurs in certain types of tumors and mostly in squamous cell carcinoma of the head and neck. In the majority of cases, psuedocystic change is the mechanism of cyst formation. However, sometimes a true cyst cavity is formed. This occurrence is unexplained and some theories are introduced to explain it. In this paper, related articles and introduced concepts are reviewed and the best conclusions of present hypotheses are provided. Cystic SCC in cervical lymph node is now considered as a typical presentation of metastatic SCC arising in the oro/nasopharynx. True cystic cavities have eosinophilic fluid content and present active transport mechanism across the epithelium; Cytokeratin7 is also expressed in the lining of these cysts, which is an accepted m... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5599902 Mon, 16 Jan 2012 05:00:00 +0100 5599902 http://www.medworm.com/index.php?rid=5585685&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F5 Conclusion: There might be a positive correlation between either inflammatory cell infiltration or interstitial fibrosis/tubular atrophy and high GSK-3beta expression in renal allograft tissue.Virtual slides: The virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/9924478946162998 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5585685 Fri, 13 Jan 2012 05:00:00 +0100 5585685 http://www.medworm.com/index.php?rid=5585686&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F4 Conclusion: The p.N370S mutation presents a large variability in the onset of the disease and its clinical manifestation supporting the view that GD should be considered as a continuum phenotype rather than a predefined classification. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5585686 Tue, 10 Jan 2012 05:00:00 +0100 5585686 http://www.medworm.com/index.php?rid=5573442&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F3 Conclusions: SMPC(+) tumors are rare, but they may be associated with a poor prognosis and have different phenotypic and genotypic characteristics from those of AMPC(+) tumors. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5573442 Fri, 06 Jan 2012 05:00:00 +0100 5573442 http://www.medworm.com/index.php?rid=5562678&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F1 Background: The diagnosis of uterine smooth muscle tumors depends on a combination of microscopic features. However, a small number of these tumors still pose difficult diagnostic challenges.Aim :To investigate progesterone receptor (PR) and p53 expression in leiomyomas (LMs), atypical leiomyomas (ALMs), smooth muscle tumors of uncertain malignant potential (STUMP), and leiomyosarcomas (LMSs) and to evaluate the potential utility of the selected immunohistochemical markers in differentiating these tumors.Materials and Methods: Immunohistochemical expression of PR and p53 was investigated in 41 uterine smooth muscle tumors comprising: 15 LMS, 4 STUMP, 6 ALM and 16 LM. Quantitative evaluation of PR and p53 expression was graded on a scale from 0 to 3+. Results: Leiomyosarcomas showed reduced... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5562678 Thu, 05 Jan 2012 05:00:00 +0100 5562678 http://www.medworm.com/index.php?rid=5562677&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F7%2F1%2F2 Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease. The etiology and treatment options of IGM remain controversial. Previous case reports have suggested that hyperprolactinemia may be associated with IGM. In the present report, we describe the first case of IGM associated with risperidone-induced hyperprolactinemia. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5562677 Thu, 05 Jan 2012 05:00:00 +0100 5562677 http://www.medworm.com/index.php?rid=5553747&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F129 Today, electronic communication is involved in all parts of our lives, either in a directed active, communicative, or passive manner. Whether to live with electronic communication or to ignore it is no longer a question. Instead, the question we have to answer is: How shall we live in our communicative environment? What can we expect? What are we forced to develop in order "to survive"?This Editorial written at the end of a really successful year of our journal Diagnostic Pathology tries to give some answers from different points of view: (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5553747 Fri, 30 Dec 2011 05:00:00 +0100 5553747 http://www.medworm.com/index.php?rid=5553746&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F130 We report the case of a 49-year-old male patient with primary pleural angiosarcoma, who presented with initial hemothorax, followed by a rapid progress to an inoperable status. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5553746 Fri, 30 Dec 2011 05:00:00 +0100 5553746 http://www.medworm.com/index.php?rid=5539744&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F128 CONCLUSION: PCR had low sensitivity and specificity in comparison to placental histology, perhaps because the vast majority of the placental infections were past infections. Further research is needed. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5539744 Fri, 23 Dec 2011 05:00:00 +0100 5539744 http://www.medworm.com/index.php?rid=5527635&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F127 In this study, we present a 24-year-old woman with a 1-month history of a rapidly enlarging abdominal mass and a CT showing an exophytic heterogeneous liver mass with a firm parietal bone mass. The patient underwent a transcatheter arterial chemoembolization (TACE) before operation, and an extended right hepatectomy and craniectomy with a negative margin was performed under general anesthesia. The masses showed histological features of oval spindle cells haphazardly arranged in the classic short-storiform or so-called patternless pattern of solitary fibrous tumors. The tumor cells showed positive immunohistochemical reactions to CD34 and bcl-2. The tumor recurred in the residual liver 2 months after operation, metastatic osteoblastic lesions in the thoracic and lumbar vertebrae were identi... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5527635 Thu, 22 Dec 2011 05:00:00 +0100 5527635 http://www.medworm.com/index.php?rid=5527636&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F126 Conclusions: The diagnostic efficiency of CK19 for PTC was slightly better than galectin-3. The utilization of these markers combined with morphologic evaluation may be helpful in the differential diagnosis of papillary thyroid carcinoma in the northeastern region of China. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5527636 Wed, 21 Dec 2011 05:00:00 +0100 5527636 http://www.medworm.com/index.php?rid=5527637&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F125 Primary angiosarcoma of the breast is a rare tumour that account for fewer than 0.05% of all malignant mammary tumours. Angiosarcoma may have an perfidious clinical onset. Radiologic findings are often nonspecific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastases. Aggressive surgical resection is the mainstay of treatment. The role of adjuvant therapy has not yet been well established.Here we present a case of a 53 year old, postmenopausal women with primary angiosarcoma arising in fibroadenoma. To our knowledge, this is the first case described in the literature to date. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5527637 Tue, 20 Dec 2011 05:00:00 +0100 5527637 http://www.medworm.com/index.php?rid=5527639&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F123 Conclusions: we described 32 Chinese cases of EMP, compare with that reported in the literature, some differences are presented, including higher percentage of grade and cases, clinically inconsistent treatment and management as well as poor outcome of the disease. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5527639 Mon, 19 Dec 2011 05:00:00 +0100 5527639 http://www.medworm.com/index.php?rid=5527638&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F124 Background: Application of virtual slides (VS), the digitalization of complete glass slides, is in its infancy to be implemented in routine diagnostic surgical pathology and to issues that are related to tissue-based diagnosis, such as education and scientific publication.Approach: Electronic publication in Pathology offers new features of scientific communication in pathology that cannot be obtained by conventional paper based journals. Most of these features are based upon completely open or partly directed interaction between the reader and the system that distributes the article. One of these interactions can be applied to microscopic images allowing the reader to navigate and magnify the presented images. VS and interactive Virtual Microscopy (VM) are a tool to increase the scientific... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5527638 Mon, 19 Dec 2011 05:00:00 +0100 5527638 http://www.medworm.com/index.php?rid=5478720&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F121 Conclusions: SCCA is overexpressed in HCC. SCCA status is associated with cell proliferation, apoptosis and survival. SCCA and Ki67 staining can predict survival. Our study results support a potential association of negative SCCA expression with other markers of poor outcome in HCC. More studies are needed to clarify the role of SCCA in HCC and expand the knowledge of the SCCA antigen in HCC patients. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5478720 Wed, 07 Dec 2011 05:00:00 +0100 5478720 http://www.medworm.com/index.php?rid=5478719&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F122 Low-grade cribriform cystadenocarcinoma (LGCCA) is a rare tumor of the salivary gland that exhibits clinically indolent behavior. In this paper, we present a case of invasive adenocarcinoma of the accessory parotid gland in a young male that exhibited histology suggestive of an association of LGCCA. A 27-year-old man presented with a subcutaneous tumor in his left cheek. The tumor was separated from the parotid gland and located on the masseter muscle. The tumor was resected, and the postoperative histological diagnosis was adenocarcinoma, not otherwise specified (ANOS). The tumor exhibited papillary-cystic and cribriform proliferation of the duct epithelium and obvious stromal infiltration. Some tumor nests were rimmed by myoepithelium positive for smooth muscle actin, p63, and cytokerati... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5478719 Wed, 07 Dec 2011 05:00:00 +0100 5478719 http://www.medworm.com/index.php?rid=5478722&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F119 A 55-year-old man presented with a large tumor in his lateral ventricles. Magnetic resonance imaging revealed disseminated lesions in the third and fourth ventricles at the time of diagnosis. The patient underwent a partial removal of the tumor in the lateral ventricles. Histologically, the surgical specimens showed glioneuronal differentiation with ganglion or ganglioid cells, Rosenthal fibers, oligodendroglia-like honeycomb appearances, a spongy pattern, perivascular pseudorosettes, and many hyalinized blood vessels. Papillary structure was not observed. The neuronal component showed a moderately high labeling index of Ki-67/MIB-1. We diagnosed this tumor as atypical intraventricular glioneuronal tumor. The disseminated lesions disappeared after chemoradiation therapy with temozolomide, ... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5478722 Tue, 06 Dec 2011 05:00:00 +0100 5478722 http://www.medworm.com/index.php?rid=5478721&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F120 We present the case of a young man, 24-year-old, with EHE of the forearm with secondary involvement of the distal radius. The location and the extension of the tumor allowed a wide excision, without the reconstruction of radius, followed by adjuvant radiotherapy, with a subsequent favorable evolution. Based on the clinical, radiographic, and pathological features of the EHE review, we concluded that it is difficult to adopt a standardized therapeutic approach due to the extremely low incidence of the bone involvement in EHE and the variable tendencies towards malignancy of this tumor. To our knowledge this is the third case of EHE with the involvement of the radius. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5478721 Tue, 06 Dec 2011 05:00:00 +0100 5478721 http://www.medworm.com/index.php?rid=5470566&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F118 Conclusion: In this study, EGFR mutations were presented in only two samples, indicating that EGFR mutations should not be employed in future trials with anti-EGFR therapies for breast cancer. However, EGFR whole gene amplification is frequently observed in patients with breast cancer. It will be of significant interest to investigate whether EGFR gene copy number is a suitable screening test for EGFR-targeted therapy for breast cancer. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5470566 Fri, 02 Dec 2011 05:00:00 +0100 5470566 http://www.medworm.com/index.php?rid=5470567&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F117 Conclusion: Our mechanical pencil tip technique is the most inexpensive easy technique among the literature. It also takes a reasonable amount of time and reduces antibody consumption during immunohistochemistry (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5470567 Thu, 01 Dec 2011 05:00:00 +0100 5470567 http://www.medworm.com/index.php?rid=5460329&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F116 Conclusions: Our results show that for at least a subset of cancer patients methylation of certain cancer related genes in PB DNA does not seem to be directly linked to somatic methylation of the same genes in tumor DNA, and therefore may only be specific to PB DNA. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5460329 Wed, 30 Nov 2011 05:00:00 +0100 5460329 http://www.medworm.com/index.php?rid=5443560&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F115 Conclusions: TEM analysis is possible in most patients and a useful tool for diagnosis of PCD. Functional and genetic analysis should be done additionally. Registers should be installed to collect all available informations and push further research. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5443560 Thu, 24 Nov 2011 05:00:00 +0100 5443560 http://www.medworm.com/index.php?rid=5424292&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F114 Conclusions: We hypothetize that there do exist changes of selected microRNAs which can undoubtedly distinguish the patients with BE from normal healthy individuals. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5424292 Thu, 17 Nov 2011 05:00:00 +0100 5424292 http://www.medworm.com/index.php?rid=5391002&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F112 Here we report the first case of carbohydrate antigen (CA) 19-9-producing early gastric adenocarcinoma arising in polyp. A solitary pedunculated polyp lesion of the stomach, measuring 26 x 20 x 20 mm, was noticed in a 76-year-old Japanese woman due to an abdominal disorder, associated with a markedly high serum CA19-9 level (2,172.6 U/ml). After endoscopic mucosal resection was performed, the CA19-9 level was drastically decreased and normalized. The scanning view of immunohistochemical staining of CA19-9 exhibited a focal, not diffuse, positive-expression in the hyperplastic epithelium and, especially, in the irregular and fused tubular glands and the mucinous material secreted into the dilated glands. In particular, microscopic examination of the strongly CA19-9-positive areas showed str... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5391002 Thu, 10 Nov 2011 05:00:00 +0100 5391002 http://www.medworm.com/index.php?rid=5391001&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F113 Conclusion: The high frequency of p.P533R mutation could be explained by the high degree of inbreeding. This is due to the richness of the genetic background of the studied population.A multidisciplinary approach is essential to develop adequate preventive program adapted to the social, cultural, and economic context. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5391001 Thu, 10 Nov 2011 05:00:00 +0100 5391001 http://www.medworm.com/index.php?rid=5391003&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F111 Conclusions: This study provides the first evidence that immunostaining with FAP-alpha and Calponin can serve as a novel marker for pathologically diagnosing whether DCIS has microinvasion. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5391003 Tue, 08 Nov 2011 05:00:00 +0100 5391003 http://www.medworm.com/index.php?rid=5391004&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F110 Background: Telecommunication has matured to a broadly applied tool in diagnostic pathology.Technology and Systems: Contemporary with the development of fast electronic communication lines (Integrated digital network services (ISDN), broad band connections, and fibre optics, as well as the digital imaging technology (digital camera), telecommunication in tissue - based diagnosis (telepathology) has matured. Open access (internet) and server - based communication have induced the development of specific medical information platforms, such as iPATH, UICC-TPCC (telepathology consultation centre of the Union International against Cancer), or the Armed Forces Institute of Pathology (AFIP) teleconsultation system. They have been closed, and are subject to be replaced by specific open access foru... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5391004 Mon, 07 Nov 2011 05:00:00 +0100 5391004 http://www.medworm.com/index.php?rid=5391005&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F109 Conclusions: Nuclear beta-catenin overexpression in metastatic SLN(s) is strongly associated with liver metastasis and may contribute to predict liver metastasis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5391005 Fri, 04 Nov 2011 04:00:00 +0100 5391005 http://www.medworm.com/index.php?rid=5366947&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F107 Conclusions Our results show a correlation between the DNA-ploidy, a fine-tuned DNA-ploidy and the HR-CGH results. Furthermore, we found significant correlation between the different ploidy groups and the clinical outcome (p (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5366947 Thu, 03 Nov 2011 04:00:00 +0100 5366947 http://www.medworm.com/index.php?rid=5366946&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F108 Conclusions: Study results revealed heterogeneity among CRCs, which could have a predictive value by identifying biologically and probably clinically different subsets of tumors with the possibly diverse response to anti-EGFR therapies. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5366946 Thu, 03 Nov 2011 04:00:00 +0100 5366946 http://www.medworm.com/index.php?rid=5366950&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F104 We present a 69-year-old woman with a chief complaint of postmenopausal bleeding. She was diagnosed as having an endometrioid adenocarcinoma by biopsy, and underwent a total abdominal hysterectomy. At the time of surgery, granulation tissue-like nodules were found on the peritoneal serosa of the uterus. In the intraoperative cytology of peritoneal washing, atypical cells were noted. The intraoperative frozen section of the peritoneal nodule revealed granulation tissue with proliferating mesothelial cells. Microscopic examination of the permanent section showed keratin granulomas without viable adenocarcinoma cells on the serosal surface of the ovaries, fallopian tubes and broad ligaments. Postoperative chemotherapy was administered. She has been alive with no evidence of recurrence for 6 m... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5366950 Fri, 28 Oct 2011 04:00:00 +0100 5366950 http://www.medworm.com/index.php?rid=5366949&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F105 Diagnosing Alzheimer's disease through MRI neuroimaging biomarkers has been used as a complementary marker for traditional clinical markers to improve diagnostic accuracy and also help in developing new pharmacotherapeutic trials. It has been revealed that longitudinal analysis of the whole brain atrophy has the power of discriminating Alzheimer's disease and elderly normal controls. In this work, effect of involving intermediate atrophy rates and impact of using uncorrelated principal components of these features instead of original ones on discriminating normal controls and Alzheimer's disease subjects, is inspected. In fact, linear discriminative analysis of atrophy rates is used to classify subjects into Alzheimer's disease and controls. Leave-one-out cross- validation has been adopted... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5366949 Fri, 28 Oct 2011 04:00:00 +0100 5366949 http://www.medworm.com/index.php?rid=5366948&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F106 Conclusions: This study describes an outbreak of VIM-2-producing P. aeruginosa in a kidney transplantation unit. Clinical spread of blaVIM-2 gene is a matter of great concern for carbapenem resistance in Tunisia. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5366948 Fri, 28 Oct 2011 04:00:00 +0100 5366948 http://www.medworm.com/index.php?rid=5350384&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F103 Conclusions, experiments demonstrate the effectiveness of the proposed algorithm in compare to other existing algorithms on various noise levels. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5350384 Wed, 26 Oct 2011 04:00:00 +0100 5350384 http://www.medworm.com/index.php?rid=5350385&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F102 Conclusions Expression of MUC1 was high (72%) in ampullary adenocarcinoma, while expressions of MUC2, MUC5AC, and MUC6 were lower. Mucins are useful markers to diagnose and identify ampullary adenocarcinoma, particularly in determining the degree of malignancy of ampullary adenocarcinoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5350385 Tue, 25 Oct 2011 04:00:00 +0100 5350385 http://www.medworm.com/index.php?rid=5350386&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F101 Conclusions: The morphometric data showed that placentas of HIV-seropositive pregnant women tend to have smaller villi than those of seronegative women. In addition, immunohistochemical testing for infectious agents helped to identify cases that were positive for microorganisms (6/112) that routine pathological examination had failed to detect. The anti-p24 antibody had a limited ability to detect HIV viral protein in this study (2/57). Correlation of immunohistochemical expression of CD8+ T cells and ICAM-1 with the presence of HIV in the placenta revealed that those expressions can act as biomarkers of inflammatory changes. There was no correlation between the data for antiretroviral therapy and morphometric or immunohistochemical data. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5350386 Mon, 24 Oct 2011 04:00:00 +0100 5350386 http://www.medworm.com/index.php?rid=5338850&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F100 Conclusions The expression of MK-1 and/or Reg might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5338850 Fri, 21 Oct 2011 04:00:00 +0100 5338850 http://www.medworm.com/index.php?rid=5317319&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F98 Conclusions: The prognosis of AC patients can be estimated based on immunohistochemical classification and OPN status. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5317319 Thu, 13 Oct 2011 04:00:00 +0100 5317319 http://www.medworm.com/index.php?rid=5317318&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F99 Kidney injury associated with chronic lymphocytic leukemia (CLL) is typically caused by direct tumor infiltration which occasionally results in acute renal failure. Glomerular involvement presenting as proteinuria or even nephrotic syndrome is exceptionally rare. Here we report a case of 54-year-old male CLL patient with nephrotic syndrome and renal failure. The lymph node biopsy confirmed that the patients had CLL with remarkable immunoglobulin light chain amyloid deposition. The renal biopsy demonstrated the concurrence of AL amyloidosis and neoplastic infiltration. Combined treatment of fludarabine, cyclophosphamide and rituximab resulted in remission of CLL, as well as the renal disfunction and nephrotic syndrome, without recurrence during a 12-month follow-up. To our knowledge, this i... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5317318 Thu, 13 Oct 2011 04:00:00 +0100 5317318 http://www.medworm.com/index.php?rid=5306563&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F97 Conclusions: Therefore, HGAL can be used in the immunostaining of FLs as the most sensitive germinal center (GC)-marker; when applied alone, it would half the immunostaining costs, reserving the use of the other two markers only to HGAL-negative cases. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5306563 Tue, 11 Oct 2011 04:00:00 +0100 5306563 http://www.medworm.com/index.php?rid=5288142&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F96 The kidney is a relatively infrequent site for solitary fibrous tumor (SFT). Among the previously reported cases, only two cases of malignant renal SFT developing via dedifferentiation from a pre-existing benign SFT have been reported. Here we reported a case of de novo malignant renal SFT clinically diagnosed as renal cell carcinoma in a 50-year-old woman. The tumor was circumscribed but unencapsulated and showed obvious hemorrhagic necrosis. Microscopically, the tumor was composed of patternless sheets of alternating hypercellular and hypocellular areas of spindle cells displaying mild to moderate nuclear atypia, frequent mitoses up to 8 per 10 high power fields, and a 20% Ki-67 proliferative index. Immunohistochemical studies revealed reactivity for CD34, CD99 and vimentin, with no stai... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5288142 Wed, 05 Oct 2011 04:00:00 +0100 5288142 http://www.medworm.com/index.php?rid=5276584&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F95 Vulvar squamous cell carcinoma with sarcoma-like stroma represents an extremely rare histological entity showing the co-existence of both epithelial and mesenchymal features: these tumors, firstly described in the skin by Martin and Stewart in 1935 have been further described in other anatomic sites including oral cavity, larynx, breast, lung and oesophagus. The complexity of the histology, as well as its aggressive clinical behaviour makes the diagnosis and the exploitment of effective therapeutic approaches very difficult, so that no definitive guidelines for treatments are currently available. Here, we describe a case of advanced stage vulvar squamous cell carcinoma with sarcoma-like stroma showing an unfavourable prognosis despite the use of an aggressive multimodal approach. A revisio... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5276584 Sat, 01 Oct 2011 04:00:00 +0100 5276584 http://www.medworm.com/index.php?rid=5276585&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F94 Dendritic cell sarcomas (DCS) are exceedingly rare entities, arising from antigen-presenting cells of the immune system. DCS are subclassified into the better characterized follicular (FDCS) [1] and interdigitating (IDCS) [2] dendritic cell sarcomas and other rare and less well classifiable dendritic cell tumors like fibroblastic reticular cell tumors, indeterminate dendritic cell tumors and dendritic cell tumors, not otherwise specified (DCT, NOS) [2]. DCS was first described in 1986 by Monda et al. [3]. Since then, nearly 300 cases, most of them FDCS, have been described in the literature. Although most DCS evolve in cervical, mediastinal, axillary and inguinal lymph nodes, also extranodal manifestations have been described [4]. The clinical behaviour of DCS is similar to that of low-gra... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5276585 Fri, 30 Sep 2011 04:00:00 +0100 5276585 http://www.medworm.com/index.php?rid=5276586&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F93 Conclusion: BM atypical immature myeloid precursors are difficult to be correctly classified in routine cytology. Although their cytoplasm is more similar to that of myeloblasts, computerized texture analysis indicates a nuclear chromatin remodeling more close to the promyelocyte, thus indicating an asynchronous intermediate maturation stage between blast and promyelocyte. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5276586 Thu, 29 Sep 2011 04:00:00 +0100 5276586 http://www.medworm.com/index.php?rid=5263388&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F92 We presented two cases of SMPPLA which were found in the last four years. Both the cases showed more than 50% of SMP in the tumor area. The majority of the stromal micropapillary clusters expressed MUC1 and epithelial membrane antigen along the outer surface of cell membrane. On the other hand, connective tissues surrounding stromal micropapillary clusters showed no reactivity for epithelial markers (thyroid transcription factor-1 and cytokeratin) or endothelial marker (D2-40 and CD34). It means clusters of SMP do not exist within air space or lymphatic or vessel lumens. The tumors with SMP often presented lymphatic permeation and vessel invasion, and intriguingly, one of the two cases showed metastasis to the mediastinal lymph node. Additionally, both the cases showed EGFR point mutations... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5263388 Thu, 29 Sep 2011 04:00:00 +0100 5263388 http://www.medworm.com/index.php?rid=5263389&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F91 Conclusion: Our results demonstrate that high nuclear expression of RBM3 in prostate cancer is associated with a prolonged time to disease progression and, thus, a potential biomarker of favourable prognosis. The value of RBM3 for prognostication, treatment stratification and follow-up of prostate cancer patients should be further validated in larger studies. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5263389 Wed, 28 Sep 2011 04:00:00 +0100 5263389 http://www.medworm.com/index.php?rid=5263390&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F90 Conclusion: ABCG2 correlated with Her-2 expression, lymph node metastasis and clinical stage in breast invasive ductal carcinoma. It could be a novel potential bio-marker which can predict biological behavior, clinical progression, prognosis and chemotherapy effectiveness. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5263390 Tue, 27 Sep 2011 04:00:00 +0100 5263390 http://www.medworm.com/index.php?rid=5263391&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F89 Conclusions: Salivary gland carcinomas express maspin and MCM2 with variable levels and cellular localization, consisting important markers of biological behavior in these tumors. The level of MCM2 expression can be used in the differential diagnosis of adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Further study with large sample size is recommended to assess their value in prediction of lymph node metastasis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5263391 Mon, 26 Sep 2011 04:00:00 +0100 5263391 http://www.medworm.com/index.php?rid=5252463&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F88 Conclusion: This study has shown that Cyscope (R) fluorescence microscope is a reliable diagnostic, sensitive and specific in diagnosing P. falciparum malaria among pregnant women in this setting. Further studies are needed to determine effectiveness in diagnosing other Plasmodium species and to compare it with other diagnostic tools e.g. rapid diagnostic tests and PCR. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5252463 Sat, 24 Sep 2011 04:00:00 +0100 5252463 http://www.medworm.com/index.php?rid=5252465&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F86 We report a 41-year-old Chinese woman with intravascular large B-cell lymphoma diagnosed by percutaneous renal biopsy. The patient was admitted to Nanfang Hospital of Southern Medical University, Guangzhou, China with complaints of high spiking fever for a month and bilateral lower limb fatigue with difficulty ambulating for the past 5 months.She had renal dysfunction with a total urinary protein of 5.61 g/dL (56.1 g/L), serum albumin of 2.89 g/dL (28.9 g/L), urea nitrogen of 2.24 mg/dL (1.6 mmol/L), and serum creatinine of 0.54 mg/dL (48 mumol/L). Bone marrow biopsy revealed myeloproliferative disorder without abnormal myeloid or lymphocytic proliferation. Positron Emission Tomography-Computed Tomography (PET-CT) showed marked bilateral swelling and enlargement of the renal parenchyma wit... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5252465 Fri, 23 Sep 2011 04:00:00 +0100 5252465 http://www.medworm.com/index.php?rid=5252464&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F87 Conclusion HER2 IHC digital image analysis based on membrane connectivity estimate was in almost perfect agreement with the visual evaluation of the pathologist and more accurate in detection of HER2 FISH-positive patients. Most immediate benefit of integrating the DA algorithm into the routine pathology HER2 testing may be obtained by alerting/reassuring pathologists of potentially misinterpreted IHC 0/1+ versus 2+ cases. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5252464 Fri, 23 Sep 2011 04:00:00 +0100 5252464 http://www.medworm.com/index.php?rid=5241030&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F85 A 44-year-old Japanese man consulted to our hospital because of cough andsputum. Chest-XP and CT revealed diffuse reticular opacities in both lungs.A transbronchial lung biopsy (TBLB) showed a moderate infiltration oflymphocytes in the alveolar septae. He was diagnosed as interstitial pneumonia,and treated by drugs. One year later, his condition deteriolated, and a large openbiopsy was performed. It showed a diffuse severe infiltration of lymphocytes in thealveolar walls and a few epithelioid granulomas. No bronchiolitis was seen.Immunohistochemical study denied lymphocyte monoclonality, and he wasdiagnosed as lymphocytic interstitial pneumonia (LIP). He was treated by steroid.Six months later, TBLB showed peribronchial lymphocyte infiltration. A large openbiopsy also revealed a severe lym... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5241030 Wed, 21 Sep 2011 04:00:00 +0100 5241030 http://www.medworm.com/index.php?rid=5241032&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F83 Conclusion: Significantly higher rate of monocytes and macrophage were detected in placentae with malaria infections. Neither placental malaria infections nor cellular infiltrates were associated with parity or lead to reduction of birth weight. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5241032 Mon, 19 Sep 2011 04:00:00 +0100 5241032 http://www.medworm.com/index.php?rid=5241031&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F84 Simple 46, XY gonadal dysgenesis syndrome, also called Swyer syndrome, is known as pure gonadal dysgenesis. Individuals with the syndrome are characterized by 46, XY karyotype and phenotypically female with female genital appearance, normal Mullerian structures and absent testicular tissue. The condition usually first becomes apparent in adolescence with delayed puberty and primary amenorrhea due to the gonads have no hormonal or reproductive potential. Herein, we report a case of dysgerminoma diagnosed in a dysgenetic gonad of a 21-year-old patient with Swyer syndrome. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5241031 Mon, 19 Sep 2011 04:00:00 +0100 5241031 http://www.medworm.com/index.php?rid=5198467&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F82 Mucosa-associated lymphoid tissue (MALT) lymphoma is a type of extranodal marginal zone B-cell lymphoma and is a distinct subtype of non-Hodgkin's lymphoma.Primary MALT lymphomas can also occur in the oral cavity, although their appearance in this location is rare. The neoplastic cells of which MALT lymphomas are composed express B-cell antigens and show monotypic immunoglobulin expression with light-chain restriction.Although neoplastic MALT lymphoma cells do not express CD5, previous studies have shown that CD5 positive MALT lymphomas are more prone to dissemination than those that do not express CD5. Moreover, there are some reports that describe kappa- and lambda- dual light chain expression in B cell malignant neoplasms.A 66-year-old Japanese woman with swelling of the right buccal mu... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5198467 Mon, 05 Sep 2011 23:00:00 +0100 5198467 http://www.medworm.com/index.php?rid=5198468&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F81 This study points to the importance of recognizing that sebaceous carcinoma can occur in young patients with no evidence for hereditary cancer risk or radiation therapy. The G199R substitution is anticipated to alter the stability of the p53 tetrameric complex. The role of UV light in the etiology of sebaceous carcinoma deserves further study. Our findings, taken together with those of others, suggest that different environmental factors could lead to the development of sebaceous carcinoma in different patients. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5198468 Sun, 04 Sep 2011 23:00:00 +0100 5198468 http://www.medworm.com/index.php?rid=5165003&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F80 Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reporte... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5165003 Thu, 25 Aug 2011 23:00:00 +0100 5165003 http://www.medworm.com/index.php?rid=5165005&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F78 Mesothelioma of tunica vaginalis is a rare neoplasm, typically demonstrating frankly malignant morphology and aggressive behavior. Rare cases of well-differentiated papillary mesotheliomas have also been reported, which, in contrast, demonstrate indolent behavior. There are, however, cases which do not fit into the well-differentiated or diffuse malignant mesothelioma categories and can be considered mesothelioma of tunica vaginalis of "uncertain malignant potential", which is an emerging diagnostic category. A 57-year-old man presented with a neoplasm in a hydrocele sac. The neoplasm was non-invasive, but showed focal complex and solid growth and it was difficult to categorize either as well-differentiated papillary mesotheliomas or malignant mesothelioma. After the initial limited resect... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5165005 Wed, 24 Aug 2011 23:00:00 +0100 5165005 http://www.medworm.com/index.php?rid=5165004&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F79 Conclusions: The present study demonstrated TIA-1 and EBER as the two most sensitive markers. There were a few CD3 and/or CD56 negative cases noted. Interestingly, losses of CD45 and/or CD7 were not uncommon while Oct2 and IRF4/MUM1 could be positive in a subset of cases. Based on the present study in conjunction with the literature review, determination of PCR-based TCR gene rearrangement analysis might not be a useful technique for making diagnosis of ENKTL. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5165004 Wed, 24 Aug 2011 23:00:00 +0100 5165004 http://www.medworm.com/index.php?rid=5149076&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F77 Conclusions: The lymphoid neoplasms of Southwest China displayed some epidemiologic features similar to those reported in literature from western and Asian countries, as well as other regions of China, whereas some subtypes showed distinct features. The high frequency of mature T/NK cell neoplasms and extranodal lymphomas, especially for extranodal NK/T-cell lymphoma, nasal type, is the most outstanding characteristic of this series. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5149076 Sun, 21 Aug 2011 23:00:00 +0100 5149076 http://www.medworm.com/index.php?rid=5121485&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F76 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5121485 Wed, 10 Aug 2011 23:00:00 +0100 5121485 http://www.medworm.com/index.php?rid=5186283&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F75 We describe the second documented case of a hepatocellular carcinoma developing in the primary liver of a patient with a rare and uncharacterized genetic symptom complex. Also present was the largest ectopic liver ever reported, measuring 12 cm in diameter which contained a solitary focus of metastatic hepatocellular carcinoma. The primary hepatocellular carcinoma is believed to have arisen in the native liver from a hepatic adenoma that was diagnosed 15 years earlier. The patient's uncharacterised condition featured prominent thick, yellow skin over the dorsum of the fingers, and was associated with follicular hyperkeratosis, abnormal plantar creases, digital clubbing, misshaped ears, a lingua plicata and an angioleiomyolipoma of the right kidney.This unique case of hepatocellular carcino... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5186283 Tue, 09 Aug 2011 23:00:00 +0100 5186283 http://www.medworm.com/index.php?rid=5112302&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F75 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5112302 Tue, 09 Aug 2011 23:00:00 +0100 5112302 http://www.medworm.com/index.php?rid=5112303&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F74 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5112303 Mon, 08 Aug 2011 23:00:00 +0100 5112303 http://www.medworm.com/index.php?rid=5112304&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F73 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5112304 Sun, 07 Aug 2011 23:00:00 +0100 5112304 http://www.medworm.com/index.php?rid=5090263&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F72 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5090263 Mon, 01 Aug 2011 23:00:00 +0100 5090263 http://www.medworm.com/index.php?rid=5072450&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F71 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5072450 Wed, 27 Jul 2011 23:00:00 +0100 5072450 http://www.medworm.com/index.php?rid=5072451&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F70 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5072451 Tue, 26 Jul 2011 23:00:00 +0100 5072451 http://www.medworm.com/index.php?rid=5065419&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F69 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5065419 Mon, 25 Jul 2011 23:00:00 +0100 5065419 http://www.medworm.com/index.php?rid=5054474&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F68 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5054474 Thu, 21 Jul 2011 23:00:00 +0100 5054474 http://www.medworm.com/index.php?rid=5043093&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F67 ${item.shortDescription} (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5043093 Wed, 20 Jul 2011 23:00:00 +0100 5043093 http://www.medworm.com/index.php?rid=5032281&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F66 In this study, we reported one case of pure rhabdomyosarcoma and two cases of urothelial carcinomas with extensive rhabdomyosarcomatous differentiation. In addition, their immunohistochemical profile was compared to that of small cell carcinoma of the bladder. Our study showed that sufficient sampling was critical for the diagnosis of urothelial carcinoma with extensive rhabdomyosarcomatous differentiation. As adult RMS in the bladder and urothelial carcinoma with rhabdomyosarcomatous differentiation shared morphological features with small cell carcinoma of the bladder, appropriate immunohistochemical stains were necessary in the differential diagnosis. We showed both rhabdomyosarcoma and rhabdomyosarcomatous areas of the urothelial carcinoma were positive for myogenin, negative for cytok... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5032281 Thu, 14 Jul 2011 23:00:00 +0100 5032281 http://www.medworm.com/index.php?rid=5032282&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F65 ABSTRACT. Primary angiosarcoma of the ovary (AS) is a rare entity with only 31 reported cases. The majority are pure angiosarcomas, the remainder are associated either with teratomas or conventional epithelial tumors. More than 50% of ovarian AS are disseminated at the time of diagnosis, the minority is detected in stage I. The prognosis of ovarian angiosarcoma in general is poor. Most reports refer to younger individuals, aged from 7 to 46 years, and only 2 case reports could be found for patients older than 64 years. Here we present a very unusual case of angiosarcoma in a 81-year-old patient. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5032282 Wed, 13 Jul 2011 23:00:00 +0100 5032282 http://www.medworm.com/index.php?rid=5012693&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F63 Amongst follicular lymphoma that transforms into a high-grade lymphoma, majority are diffuse large B cell lymphoma. Here we reported a rare atypical Burkitt's lymphoma transformation from an asymptomatic follicular lymphoma. Lymph node biopsy showed a composite lymphoma with infiltration of the inter-follicular areas by high grade small non-cleaved lymphoma cells amongst neoplastic follicles. Moreover, FISH and molecular genetic study confirmed concomitant MYC translocations with t(14;18) in the high-grade component, thereby testifying the atypical Burkitt's lymphoma has transformed from an undiagnosed antecedent follicular lymphoma. The disease followed an aggressive clinical course, terminating in refractory disease 13 months after diagnosis. This is followed by a comprehenisve review of... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5012693 Thu, 07 Jul 2011 23:00:00 +0100 5012693 http://www.medworm.com/index.php?rid=5012692&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F64 Background: Excessive wound healing following glaucoma filtration surgery is the main determinant of surgical failure, resulting from the activation of human Tenon's capsule fibroblasts (HTFs). To mitigate the excessive wound healing, the topicall use of antiproliferative agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), has increased the surgery success rate, but the traditional administration of these agents can result in a variety of toxicities with nonspecific damage. However, modulation of the wound healing process to prevent excessive fibroblast proliferation and scar formation can play a major role in improving the outcome of surgery. Therefore, the search for alternative modes of drug delivery and new agents is needed to minimize the ocular complications and improve the ... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5012692 Thu, 07 Jul 2011 23:00:00 +0100 5012692 http://www.medworm.com/index.php?rid=5001874&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F62 Background: primary tumours of the middle ear are much less commonly encountered in clinical practice than non neoplastic lesions. Middle ear adenocarcinoma is a very rare, locally invasive neoplasm assumed to arise from the middle ear mucosa. Because the natural course and clinical behavior of this neoplasm are far from established, the sporadic reports of such cases continue to provide basis for better understanding.Case description: a case of low grade adenocarcinoma of the middle ear is described in details with regard to its clinical presentation, radiological findings, histopathological, immunohistochemical and ultrastructural findings. The tumour recurred four times (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5001874 Wed, 06 Jul 2011 23:00:00 +0100 5001874 http://www.medworm.com/index.php?rid=5001876&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F60 We recently encountered an unusual case of Composite lymphoma (CL) in the anterior mediastinum arising in a 37-year-old woman who presented initially with continuous pain in the right shoulder and chest. The woman had been suffered from continuous pain for three months before she went to our department of cardiovascular surgery. Chest computed tomography scan revealed the oval space-occupying lesion of anterior mediastinum. Surgery was performed and the disease was diagnosed pathologically as CL which composed of nodular sclerosing Hodgkin lymphoma and diffuse large B-cell lymphoma, via hematoxylin-eosin (H&E), immunohistochemical staining and in situ hybridization. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5001876 Tue, 05 Jul 2011 23:00:00 +0100 5001876 http://www.medworm.com/index.php?rid=5001875&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F61 Conclusions: ER-b expression is reduced in high grade prostate cancers compared to low & intermediate grade ones (P value 0.027). (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5001875 Tue, 05 Jul 2011 23:00:00 +0100 5001875 http://www.medworm.com/index.php?rid=5001877&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F59 Conclusions: Immunohistochemical analysis of D2-40 combined with p16INK4A may have a significant implication in clinical practice for better identifying the grade of cervical intraepithelial neoplasia, especially for distinguishing CIN1 from CIN2/3. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=5001877 Mon, 04 Jul 2011 23:00:00 +0100 5001877 http://www.medworm.com/index.php?rid=4988051&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F58 Background: The tumor suppressor gene p53 is involved in the control of cell proliferation, particularly in stressed cells. p53 gene mutations are the most frequent genetic event found in human cancers. Fanconi Anemia (FA) is the most common representative of inherited bone marrow failure syndromes (IBMFS) with a leukemic propensity. p53 DNA alteration has not been studied before in Egyptian children with FA. Patients and methods: we investigated p53 DNA in the bone marrow and peripheral blood of forty children, FA (n=10), acquired aplastic anemia (AAA) (n=10), and immune thrombocytopenia ( ITP) as a control (n=20), using real-time PCR by TaqMan probe assay Results Mutation of p53 gene was demonstrated in the BM of 90% (9/10) of children with FA, compared to 10% (1/10) in AAA (p (Source: D... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4988051 Wed, 29 Jun 2011 23:00:00 +0100 4988051 http://www.medworm.com/index.php?rid=4963474&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F57 Conclusions: The extremely low incidence of EGFR protein expression and gene amplification in Saudi breast cancer patients as compared to Western populations is most probably ethnically related as supported by our previous finding in the same cohort of a spectrum of molecular breast cancer types that is unique to the Saudi population and in stark contrast with Western and other regionally based studies. Further support to this view is provided by earlier studies from Saudi Arabia that have similarly shown variability in molecular breast cancer subtype distribution between Saudi and Caucasian populations as well as a predominance of the high-grade pathway in breast cancer development in Middle East women. More studies on EGFR in breast cancer are needed from different regions of Saudi Arabi... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4963474 Thu, 23 Jun 2011 23:00:00 +0100 4963474 http://www.medworm.com/index.php?rid=4963476&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F55 A rare case is provided of a 74 year old man who presented with ascites of unknown etiology. CT scan of the abdomen revealed extensive omental caking, and omental biopsy cytogenetics showed findings in keeping with a diagnosis of desmoplastic small round cell tumour (DSRCT). This case is unique in that it involves a significantly older patient, negative WT1 immunohistochemical staining, and negative cytology. Despite repeated paracenteses and fluid management, the patient died in hospital secondary to renal complications. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4963476 Wed, 22 Jun 2011 23:00:00 +0100 4963476 http://www.medworm.com/index.php?rid=4963475&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F56 We present a case in a 37-year-old woman with classical clinical and pathological features of endocervicosis. The unusual observation of endocervical-like mucinous epithelium in continuity with the urothelium in addition to fully developed endocervicosis prompted immunohistochemical profiling of the case using antibodies to cytokeratins (AE1/AE3, CK19, CK7, CK5/6, CK20), HBME-1, estrogen receptor (ER) and progesterone receptor (PR) to assess the relationship of the surface mucinous and endocervicosis glandular epithelia. The surface mucinous epithelium, urothelium and endocervicosis glands were immunopositive for AE1/AE3, CK7 and CK19 while CK20 was only expressed by few urothelial umbrella cells. The surface mucinous epithelium was CK5/6 and HBME-1 immunonegative but showed presence of E... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4963475 Wed, 22 Jun 2011 23:00:00 +0100 4963475 http://www.medworm.com/index.php?rid=4940444&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F54 Discussion: In a total of 77 patients, we identified the H1, H2, H3 and the infrequent H5 haplotypes. The H1 and H2 haplotypes, which have the same amino acid sequence in the recombinant F8 molecules used clinically, are the most represented with the frequency of 0.763 and 0.157 respectively. This distribution is almost similar to that of Caucasians in which the frequencies are respectively 0.926 and 0.074, whereas it is 0.354 and 0.374 among Subsaharians. Four patients with inhibitors studied here have the H1 haplotype. For one patient who has a large deletion including the exon 10 we can't identify his haplotype. Theses frequencies may explain partially the low level of inhibitors in our patients. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4940444 Thu, 16 Jun 2011 23:00:00 +0100 4940444 http://www.medworm.com/index.php?rid=4940445&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F53 The recent introduction of bronchoscopically recovered cryobiopsy of lung tissue has opened up new possibilities in the diagnosis of neoplastic and non-neoplastic lung diseases in various aspects. Most notably the morphological diagnosis of peripheral lung biopsies promises to achieve a better yield with a high quality of specimens. To better understand this phenomenon, its diagnostic options and perspectives, this study morphometrically compares 15 cryobiopsies and 18 transbronchial forceps biopsies of peripheral lung tissue a priori without considering clinical hit ratio or integration of results in the clinical diagnostic processing. Cryotechnically harvested specimens were significantly larger (mean: 17.1 +/- 10.7 mm^2 versus 3.8 +/- 4.0 mm^2) and contained alveolar tissue more often. ... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4940445 Wed, 15 Jun 2011 23:00:00 +0100 4940445 http://www.medworm.com/index.php?rid=4916083&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F51 In conclusion, the author reported a rare case of simultaneous EMEA and CIN 3 with extensive immunohistochemical findings. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4916083 Thu, 09 Jun 2011 23:00:00 +0100 4916083 http://www.medworm.com/index.php?rid=4916082&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F52 Discussion and conclusion: Pediatric/CT-associated GISTs and sporadic GISTs of the adults differ significantly from each other with regard to patients' age, gender, tumor localisation, histomorphological growth pattern, mutational status and risk for metastasis. Our cases of pediatric/young adult GISTs show all characteristics of CT except for the absence of other components of the triad.Therefore these GISTs are probably not sporadic, but may represent either early manifestation or forme fruste of the CT. Thus, these patients need to be regularly examined for the development of extraadrenal paraganglioma or pulmonary chondroma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4916082 Thu, 09 Jun 2011 23:00:00 +0100 4916082 http://www.medworm.com/index.php?rid=4906680&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F49 Background: It's well recognized that X-linked inhibitor of apoptosis (XIAP) was the most potent caspase inhibitor and second mitochondria-derived activator of caspase (Smac) was the antagonist of XIAP. Experiments in vitro identified that down regulation of XIAP expression or applying Smac mimics could sensitize breast cancer cells to chemotherapeutics and promote apoptosis. However, expression status and biologic or prognostic significance of XIAP/Smac in breast invasive ductal carcinoma (IDC) were not clear. The present study aimed to investigate relationship among expression status of XIAP/Smac, apoptosis index (AI), clinicopathologic parameters and prognosis in IDC. Methods: Immunohistochemistry and TUNEL experiment were performed to detect expression of XIAP, Smac, ER, PR, HER2 and A... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4906680 Mon, 06 Jun 2011 23:00:00 +0100 4906680 http://www.medworm.com/index.php?rid=4906679&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F50 We describe a case of a female patient who developed significant respiratory dysfunction as the principal clinical sign. Video-assisted thoracoscopy was performed and a histological pattern of nonspecific interstitial pneumonia (NSIP) was found. A pathological diagnosis suggested careful follow-up with extensive immunological screening which then detected Raynaud's phenomenon and positivity of antinuclear antibodies. After a multidisciplinary discussion (pneumologist, radiologist, pathologist and rheumatologist) a final diagnosis of NSIP associated with UCTD was made. The diagnosis of UCTD should be considered when NSIP is diagnosed even in cases with evident first clinical manifestations of severe respiratory dysfunction. A multidisciplinary approach in the field of interstitial lung dise... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4906679 Mon, 06 Jun 2011 23:00:00 +0100 4906679 http://www.medworm.com/index.php?rid=4897441&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F48 Conclusion: Our findings provided evidences that multiple genes were aberrantly methylated in lung tumorigenesis, and demonstrated the promoter methylation was closely associated with clinicopathologic characteristics of NSCLC. More importantly, we first revealed promoter methlation may be served as a potentially increased risk factor for pleural indentation of NSCLC patients. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4897441 Fri, 03 Jun 2011 23:00:00 +0100 4897441 http://www.medworm.com/index.php?rid=4897442&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F47 Conclusion: The identification of these mutations should facilitate prenatal diagnosis and counseling for MPS I in Tunisia. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4897442 Thu, 02 Jun 2011 23:00:00 +0100 4897442 http://www.medworm.com/index.php?rid=4879651&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F46 We report a case of pure squamous cell carcinoma involving the prostate and urinary bladder and describe the diagnostic dilemmas that we faced in trying to determine its origin. The patient was diagnosed ten years ago with prostatic adenocarcinoma treated with radioactive seed implantation. During the last year he also underwent a TURP procedure for urinary obstruction complicated by multiple infections. Postsurgery, the patient developed colo-urethral fistula and decision to perform cystprostatectomy was taken. Excision illustrated a tumor mass replacing the entire prostate that microscopically proved to be squamous cell carcinoma. The challenge that we encountered was to determine its origin, the possibilities being divergent differentiation from adenocarcinoma post radiation therapy, de... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4879651 Mon, 30 May 2011 23:00:00 +0100 4879651 http://www.medworm.com/index.php?rid=4856944&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F43 Conclusions: Our data show that these markers may assist significantly in the evaluation of proliferative activity in anaplastic astrocytomas and even have prognostic value. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4856944 Mon, 23 May 2011 23:00:00 +0100 4856944 http://www.medworm.com/index.php?rid=4856943&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F44 Conclusions: In DC, high CD10 and osteopontin expression may indicate the neoplastic potentiality of certain areas. In UCA & MCA, high CD10 and osteopontin expression may identify areas with locally invasive behavior and high risk of recurrence. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4856943 Mon, 23 May 2011 23:00:00 +0100 4856943 http://www.medworm.com/index.php?rid=4856945&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F42 Conclusion: The identification of these mutation and polymorphisms and their genotype-phenotype correlation should facilitate prenatal diagnosis and counseling for MPS II in Tunisia, where a very high rate of consanguinity exists. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4856945 Sun, 22 May 2011 23:00:00 +0100 4856945 http://www.medworm.com/index.php?rid=4844437&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F41 We report a case of coexistence of PSH and primary adenocarcinoma in a young female occurring in the same pulmonary nodular mass of right lower lobe. The solitary mass of lung was well-circumscribed on chest computed tomography (CT) and gross examination. Histologically, the mass contained two separated portions and displayed typically histological features of PSH and acinar adenocarcinoma, respectively. In PSH portion, the tumor was composed of sheets of round cells with scattered surface cuboidal cells forming small tubules. Both round and surface cells were diffusely positive for epithelial membrane antigen (EMA) and thyroid transcription factor-1 (TTF-1), but lack immunoreactivity for pancytokeratin in round cells. In adenocarcinoma portion, the tumor cells formed irregular-shaped glan... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4844437 Thu, 19 May 2011 23:00:00 +0100 4844437 http://www.medworm.com/index.php?rid=4808132&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F40 Background: Type 2 diabetes is mainly caused by insulin resistance. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an important candidate for causing insulin resistance. Methods: The CEACAM1 expression was evaluated immunohistochemically in the liver tissues of 99 severely obese or non-obese subjects with or without diabetes. The CEACAM1 expression was classified into two categories: a normal expression or a decreased expression. Results: The CEACAM1 expression was markedly decreased in the hepatocytes with macrovesicular steatosis. A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. The incidence of a decreased CEACAM1 expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes (p (Source: Diagn... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4808132 Tue, 10 May 2011 23:00:00 +0100 4808132 http://www.medworm.com/index.php?rid=4750054&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F39 Conclusion: This paper, showed a heterogeneous pattern of mutations and polymorphisms among Tunisian patients. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4750054 Mon, 25 Apr 2011 23:00:00 +0100 4750054 http://www.medworm.com/index.php?rid=4745538&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F38 We report a 32-year-old woman (1-gravid, 1-para) with a vesicular lesion in her uterus that was pointed out on ultrasound at 8 weeks' gestation. Amniocentesis at 15 weeks' gestation showed a normal female karyotype, 46XX. As the pregnancy advanced, the mole-like lesion became relatively reduced. Throughout gestation, the maternal human chorionic gonadotropin level was normal, but the serum alpha fetoprotein level rose as her pregnancy progressed. Her fetus did not exhibit any remarkable anomalies. The patient visited our hospital complaining of a diminished feeling of fetal movements at 36 weeks 5 days' gestation, and intrauterine fetal death (IUFD) was confirmed. She delivered a 2336-g female without any definite anomalies. A pathological examination led to a diagnosis of placental mesenc... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4745538 Sat, 23 Apr 2011 23:00:00 +0100 4745538 http://www.medworm.com/index.php?rid=4728025&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F37 We report a case of osteosarcoma of the bladder diverticulum in a 68-year old man, which clinically mimicked intradiverticular calculus. To our knowledge, this is the second case described in the literature to date, and the first in English literature. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4728025 Sun, 17 Apr 2011 23:00:00 +0100 4728025 http://www.medworm.com/index.php?rid=4720870&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F36 Conclusions: The positive rate for maspin is the highest among known basal and myoepithelial markers, and strongly correlates with basal markers in TN breast cancer. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4720870 Fri, 15 Apr 2011 23:00:00 +0100 4720870 http://www.medworm.com/index.php?rid=4716619&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F35 A case of malignant mesenchymoma of the bladder containing leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, and myxomatous components is described. The primary pedunculated tumor measuring 14 by 13 by 7 cm and weighing 343 g arose from the left trigone of the bladder and was treated by total cystectomy. The histogenesis of malignant mesenchymomas and their optimal management strategy and prognosis remain uncertain. Herein, we present the fifth case of malignant mesenchymoma of the urinary bladder to be reported in the literature, which presented five unrelated differentiated tissues more than did previously reported cases. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4716619 Thu, 14 Apr 2011 23:00:00 +0100 4716619 http://www.medworm.com/index.php?rid=4706254&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F34 Conclusions: Biopsy print, combining a molecular point of view to the routinely hystopathological analysis of prostate biopsies, should be a useful tool to improve the diagnosis of PCa. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4706254 Tue, 12 Apr 2011 23:00:00 +0100 4706254 http://www.medworm.com/index.php?rid=4700115&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F33 Conclusions: The CD20 expression in CLL is significantly lower than in most histological types of mature B-cell lymphomas in which it appears to be comparable. Approximately 25% of B-cell lymphoma patients have the CD20 expression below the cut-off value showing that the low CD20 expression might be more common than presumed from our previous study. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4700115 Mon, 11 Apr 2011 23:00:00 +0100 4700115 http://www.medworm.com/index.php?rid=4688773&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F32 Conclusions: Angiomatoid giant cellular blue nevus arising from the vagina during pregnancy is extremely rare. The low proliferative index and absence of cytologic pleomorphism, or necrosis, supports a benign biological behavior. Clinical follow-up showed no evidence of recurrence at one year after the resection of the mass. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4688773 Thu, 07 Apr 2011 23:00:00 +0100 4688773 http://www.medworm.com/index.php?rid=4688775&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F30 Conclusions: UC-associated carcinoma showed poorer differentiation when the carcinoma invaded submucosa or deeper parts, which may influence the poorer prognosis. The invasive behavior of UC-associated carcinoma is more associated with CD44 cleavage than with basement membrane disruption or sialyl-Lewis-antigen alteration. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4688775 Wed, 06 Apr 2011 23:00:00 +0100 4688775 http://www.medworm.com/index.php?rid=4688774&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F31 The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary. This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4688774 Wed, 06 Apr 2011 23:00:00 +0100 4688774 http://www.medworm.com/index.php?rid=4688776&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F29 Conclusions: MLL were frequently accompanied with CCL, ADH or low grade DCIS. Complete resection may be recommended in case of MLL with ADH or DCIS because of intralesional heterogeneity and the probabilities of relapse. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4688776 Tue, 05 Apr 2011 23:00:00 +0100 4688776 http://www.medworm.com/index.php?rid=4655276&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F27 Conclusions: In the present study, we revealed that the degree of luminal narrowing of the pulmonary arteries varied from case to case, and our results suggested that pulmonary hypertension in PTTM occurs in selected cases which have a widespread pulmonary lesion with severe luminal narrowing in the smaller arteries. Furthermore, our immunohistochemical examination indicated that gastric carcinoma inducing PTTM shows a higher TF-positive rate than typical gastric carcinoma. However, it remains still obscuring whether gastric carcinoma inducing PTTM shows a higher VEGF or OPN-positive rate as determined by immunohistochemistry. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4655276 Tue, 29 Mar 2011 23:00:00 +0100 4655276 http://www.medworm.com/index.php?rid=4633451&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F25 Conclusions: The results suggest that the paucity of immunohistochemical SP-A expression in alveolar epithelial cells in diseased areas (i.e. regenerative/hyperplastic alveolar epithelial cells) may predict a worse prognosis for patients with IIPs, especially patients with UIP. A prospective study is needed to confirm these results. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4633451 Fri, 25 Mar 2011 00:00:00 +0100 4633451 http://www.medworm.com/index.php?rid=4633452&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F24 Conclusions: In our series, a significant change in size of the cyst with accompanying symptoms was observed in one case only. Asymptomatic patients with simple intratesticular cysts without associated features of bias towards malignancy can be discharged without need for further follow-up. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4633452 Thu, 24 Mar 2011 00:00:00 +0100 4633452 http://www.medworm.com/index.php?rid=4623972&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F23 Conclusions: The results of this first trial provide evidence that the Powered device delivers larger-volume bone marrow specimens for pathology evaluation. In addition, bone marrow specimens were secured more rapidly and subjects experienced less intermediate term pain when the Powered device was employed. Further study is needed to determine if clinicians more experienced with the Powered device will be able to use it in a manner that significantly reduces needle insertion pain; and to compare a larger sample of pathology specimens obtained using the Powered device to those obtained using traditional manual biopsy needles. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4623972 Wed, 23 Mar 2011 00:00:00 +0100 4623972 http://www.medworm.com/index.php?rid=4618268&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F21 We describe here an unusual case of PEH in a 42-year-old female with a 6.0cm dominant mass along with bilateral multiple calcified small nodules measuring 0.2-1.0cm in diameter with a 25-year plus followup history. Overall histologic findings of the solitary tumor accorded with conventional PEH. While multiple calcified small nodules were composed predominantly of intra-alveolar homogeneously eosinophilic matrix, and only a few bland small cells were embedded in it. This lesion has never been reported in the literature. After comprehensive analysis of morphology, radiography, histochemistry, immunohistochemistry and differential diagnoses, PEH presenting multiple calcified small nodules was confirmed. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4618268 Mon, 21 Mar 2011 00:00:00 +0100 4618268 http://www.medworm.com/index.php?rid=4618267&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F22 Conclusion: The application of the presented protocol and method enabled finding pathological changes in tissue material regardless of localization and size of abnormalities in the sample volume. Proteomic profile as a complex, rich in signals spectrum of proteins can be expressed as a single point in multidimensional space and than analysed using advanced statistical methods. This approach seems to provide more precise information about a pathology and may be considered in futer evaluation of biomarkers for clinical applications in different pathology. Multiparameter statistical methods may be helpful in elucidation of newly expressed sensitive biomarkers defined as many factors "in one point". (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4618267 Mon, 21 Mar 2011 00:00:00 +0100 4618267 http://www.medworm.com/index.php?rid=4602732&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F20 In the comment we point out that we have never found carbon nanoparticles in connection with laser printer emission experiments. Our article cited by Theegarten et al. states that the ultra-fine particles emitted from laser printers are volatile and are not original toner constituents. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4602732 Thu, 17 Mar 2011 00:00:00 +0100 4602732 http://www.medworm.com/index.php?rid=4585106&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F19 Conclusion: We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. ETV6-NTRK3 rearrangements have been described in secretory breast carcinoma and congenital fibrosarcoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4585106 Tue, 15 Mar 2011 00:00:00 +0100 4585106 http://www.medworm.com/index.php?rid=4578904&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F18 This study aimed to identify the factors associated with ALNM in breast carcinoma, with particular emphasis on basal-like phenotype. Methods: Breast carcinoma patients (n=210) who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy were included in this study. Pathological and immunohistochemical data including individual receptor/gene status was collected for analysis. The basal phenotype status was ascertained using the basal cytokeratin markers CK5, CK14, CK17 and EGFR. Results: ALNM was found in 55% (n=116) of the patients. On univariate analysis, multicentric disease, large tumor size (>2cm), vascular and lymphatic invasion, epithelial hyperplasia, necrosis, in situ carcinoma and perineural invasion were associa... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4578904 Sun, 13 Mar 2011 00:00:00 +0100 4578904 http://www.medworm.com/index.php?rid=4567725&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F17 Conclusion: Our newly constructed web based portal is an important tool for the management of research samples of our histological core facility and facilitates significantly interdisciplinary and transregional research. It is freely available for scientific use. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4567725 Thu, 10 Mar 2011 00:00:00 +0100 4567725 http://www.medworm.com/index.php?rid=4503937&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F15 We report here two cases of well differentiated HCC with an unusual reticulin staining pattern. A strongly positive reticulin network was preserved within the tumor, which surrounded individual tumor cells in a monolayered trabecular pattern. At the same time, an increased CD34 stain was present in the tumor. This unusual reticulin pattern represents part of the diverse reticulin staining patterns seen in HCC. Although this staining pattern is rare, it should be recognized when diagnosing well-differentiated HCC in small samples such as cellblock of fine needle aspiration or small core biopsies. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4503937 Tue, 22 Feb 2011 00:00:00 +0100 4503937 http://www.medworm.com/index.php?rid=4434235&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F14 The patient was an 84-year-old woman who had the onset of truncal ataxia at age 77 and a history of Basedow's disease. Her ataxic gait gradually deteriorated. She could not walk without support at age 81 and she was admitted to our hospital at age 83. Gaze-evoked nystagmus and dysarthria were observed. Mild ataxia was observed in all limbs. Her deep tendon reflex and sense of position were normal. IgA anti-gliadin antibody, IgG anti-gliadin antibody, anti-SS-A/Ro antibody, anti-SS-B/La antibody and anti-TPO antibody were positive. A conventional brain MRI did not show obvious cerebellar atrophy. However, MRI voxel based morphometry (VBM) and SPECT-eZIS revealed cortical cerebellar atrophy and reduced cerebellar blood flow. IVIg treatment was performed and was moderately effective. After he... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4434235 Fri, 04 Feb 2011 00:00:00 +0100 4434235 http://www.medworm.com/index.php?rid=4402186&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F13 This report expands the existing spectrum of SECs. Serous borderline tumor of ovary like surface epithelial changes could be misleading if present in an endometrial biopsy or curettings. Therefore, knowledge of this morphologic variation is important. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4402186 Thu, 27 Jan 2011 00:00:00 +0100 4402186 http://www.medworm.com/index.php?rid=4384112&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F12 Background: Claudins are integral membrane proteins that are involved in forming cellular tight junctions. One member of the claudin family, claudin-3, has been shown to be overexpressed in breast, ovarian, and pancreatic cancer. Here we use immunohistochemistry to evaluate its expression in benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), normal tissue adjacent to prostatic adenocarcinoma (NAC), primary prostatic adenocarcinoma (PCa), and metastatic prostatic adenocarcinoma (Mets). Methods: Tissue microarrays were immunohistochemically stained for claudin-3, with the staining intensities subsequently quantified and statistically analyzed using a one-way ANOVA with subsequent Tukey tests for multiple comparisons or a nonparametric equivalent. Fifty-three cases... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4384112 Fri, 21 Jan 2011 00:00:00 +0100 4384112 http://www.medworm.com/index.php?rid=4374423&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F11 Conclusion: Polymorphisms may be useful for carrier detection and prenatal diagnosis in informative families whose specific mutations have not been identified. The determination of haplotypes can also determine the origin of some mutations in a population. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4374423 Thu, 20 Jan 2011 00:00:00 +0100 4374423 http://www.medworm.com/index.php?rid=4374424&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F10 Osteoid osteoma of the spine is a relatively rare bone-forming tumor. Pain that is worse at night and relieved by aspirin and muscle contracture are the most characteristic symptoms of spinal osteoid osteoma. Although radicular pain occasionally occurs in spinal osteoid osteoma, spinal cord and nerve root compression is absent in most cases. Although the causes of radicular pain appear to be associated with tumorous inflammation, there have been no presentations of histological findings of inflammation around the nerve root. We have presented here two rare cases of spinal osteoid osteoma which caused radiculopathy and the first histological evidence of tumorous inflammation as a cause of radiculopathy in osteoid osteoma near the intervertebral foramen. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4374424 Wed, 19 Jan 2011 00:00:00 +0100 4374424 http://www.medworm.com/index.php?rid=4365507&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F8 We present two fatal cases of non - alcohol associated cardiac beriberi. An acute myocardial infarction was observed in one case; extensive colliquative myocytolisis (grade 2) was described in the second case respectively. Morphologically, myocardial necrosis and colliquative myocytolysis are the histologic hallmarks of this acute, rare clinical entity. An increase in apoptotic myocytes was demonstrated probably sustaining the cardiogenic shock. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4365507 Wed, 19 Jan 2011 00:00:00 +0100 4365507 http://www.medworm.com/index.php?rid=4365506&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F9 We report a case of a 69-year-old man with dropped head syndrome associated with isolated neck extensor myopathy (INEM). Over a period of 2 years, he exhibited progressive inability to lift his chin off his chest, resulting in the dropped head position that impaired his activities of daily living. He had a disturbed gait with severe imbalance of spinal alignment. Computed tomography revealed osseous contracture of cervical vertebral bodies in flexed position. Anterior combined posterior reconstruction surgery yielded a successful outcome in his activities of daily living, including his walking balance of spinal alignment. Pathologic study confirmed myogenic atrophy in the cervical extensor muscles. We suggest that consideration for surgical management should be given to dropped head syndr... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4365506 Wed, 19 Jan 2011 00:00:00 +0100 4365506 http://www.medworm.com/index.php?rid=4365508&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F7 Because metaplastic carcinoma of the breast encompasses a great variety of histopathology, diagnostic challenges abound, especially within the realm of cytology. The authors compiled and studied an eight-case series comprised of metaplastic breast carcinomas and lesions initially suspicious cytologically for metaplastic carcinoma in order to assess the degree of cytologic-histologic correlation and to identify recurring problematic themes surrounding the cytology-based diagnosis of this neoplasm.The cytologic and histologic slides from eight breast lesions were collected and analyzed through a seven-year retrospective search of case files at our institution. Based on cytologic characteristics, the cases were separated into three groups. Group 1 consisted of three cases presenting with poor... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4365508 Tue, 18 Jan 2011 00:00:00 +0100 4365508 http://www.medworm.com/index.php?rid=4357670&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F6 Conclusions: NuclearQuant v. 1.13 application for PannoramicTM Viewer v. 1.14 software application proved to be a reliable image analysis tool for pathologists testing ER and PR status in breast cancer. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4357670 Tue, 18 Jan 2011 00:00:00 +0100 4357670 http://www.medworm.com/index.php?rid=4333899&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F5 Conclusion: We report a unique case of ASCC arising in cecum and on this way expands the range of tumors originating in colon. Reports of more cases of colonic ASCC would possibly help to elucidate origin, clinical behavior and therapy of these tumors. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4333899 Tue, 11 Jan 2011 00:00:00 +0100 4333899 http://www.medworm.com/index.php?rid=4328173&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F3 We describe two cases of large solitary luteinized follicle cyst of pregnancy and puerperium (LSLFCPP) with new clinicopathologic findings. The first case occurred in a 40-year old woman who was found to have a left ovarian mass during the third trimester of pregnancy. The patient delivered a full term healthy female infant via caesarean section. The ovarian mass was removed by oophorectomy. The specimen showed a unilocular, thin-walled, clear fluid filled cyst measuring 15 x 12 x 5 cm. Microscopically, the cyst was lined by single to multiple layers of luteinized cells with mainly small, round and regular nuclei and focally enlarged, bizarre, and hyperchromatic nuclei. Occasional mitotic figures were seen. The cyst wall showed marked edema and nests of luteinized cells that were morpholog... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4328173 Mon, 10 Jan 2011 00:00:00 +0100 4328173 http://www.medworm.com/index.php?rid=4319978&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F6%2F1%2F2 Electronic information transfer has replaced previous written information in nearly, if not all fields of communication to a high percentage. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4319978 Fri, 07 Jan 2011 00:00:00 +0100 4319978 http://www.medworm.com/index.php?rid=4279252&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F83 Background: To evaluate the diagnostic utility of alpha-methylacyl CoA racemase (P504S) & HMWCK (34betaE12) in morphologically difficult prostate cancer. Methods: A total of 1034 cases were reviewed and divided into benign (585) malignant (399) and suspicious (50). Immunohistochemistry with HMWCK and AMACR was done on the 50 suspicious cases along with controls. Results: Forty nine suspicious cases were resolved by using both markers where as 1 case was resolved by further support with CD68. The original diagnosis was changed in 15 of 50 (30%) suspicious cases from benign to malignant, one case from benign to high grade PIN and in one case from malignant to benign. Change of diagnosis was seen in 17 of 50 (34%) suspicious cases with a significant p value of 0.002. The overall diagnosis was... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4279252 Wed, 22 Dec 2010 00:00:00 +0100 4279252 http://www.medworm.com/index.php?rid=4269254&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F82 We present a case of metastasis to the breast from a pulmonary adenocarcinoma, with extensive micropapillary component, diagnosed concomitantly with the primary tumor. A 73-year-old female presented with dyspnea and dry cough of 4 weeks duration and a massive pleural effusion was found on a chest radiograph. Additionally, on physical examination a poorly defined mass was noted in the upper outer quadrant of the left breast. The patient underwent bronchoscopy, excitional breast biopsy and medical thoracoscopy. By cytology, histology and immunohistochemistry primary lung adenocarcinoma with metastasis to the breast and parietal pleura was diagnosed. Both the primary and metastatic anatomic sites demonstrated histologically extensive micropapillary component, which is recently recognized as a... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4269254 Fri, 17 Dec 2010 00:00:00 +0100 4269254 http://www.medworm.com/index.php?rid=4269255&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F81 A 27-year-old female white-collar worker was diagnosed in 1998 with mesothelioma eight and one-half years following first exposure as a bystander to debris in a site in which asbestos-containing building materials were being dismantled and rebuilding work took place. Prodromal back pain had been present for a year and a half. She underwent extrapleural pneumectomy and received an intrapleural infusion of cisplatin post-operatively. Exposure to asbestos was verified by contemporary reports and lung biopsy, which demonstrated asbestos bodies and microscopic interstitial fibrosis -conforming evidence for asbestosis. The patient is alive and well 12 years after diagnosis and 14 years after onset of symptoms. The combination of an extremely short latency period and long survival following occup... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4269255 Thu, 16 Dec 2010 00:00:00 +0100 4269255 http://www.medworm.com/index.php?rid=4243456&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F80 Conclusions: Decreased expression of selenium-binding protein 1 in uterine leiomyoma may indicate a role of the protein in tumorigenesis. Our findings may provide a basis for future studies concerning the molecular mechanisms of selenium-binding protein 1 in tumorigenesis as well as the possible use of selenium in prevention and treatment of uterine leiomyoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4243456 Thu, 09 Dec 2010 00:00:00 +0100 4243456 http://www.medworm.com/index.php?rid=4235222&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F78 Background: Ovarian cancer is the second most common cancer of the female genital tract in the United Kingdom (UK), accounting for 6% of female deaths due to cancer. This cancer is associated with poor survival and there is a need for new treatments in addition to existing chemotherapy to improve survival. Potassium (K+) channels have been shown to be overexpressed in various cancers where they appear to play a role in cell proliferation and progression.Objectives: To determine the expression of the potassium channels Eag and HERG in ovarian cancer tissue and to assess their role in cell proliferation. Methods: The expression of Eag and HERG potassium channels was examined in an ovarian cancer tissue microarray. Their role in cell proliferation was investigated by blocking voltage-gated po... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4235222 Tue, 07 Dec 2010 00:00:00 +0100 4235222 http://www.medworm.com/index.php?rid=4235221&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F79 Conclusions: Our results indicate that altered miRNA expression is involved in GH-secreting pituitary adenomas transformation, which will shed light on the mechanisms for the treatment of acromegaly by SSA. Identification and characterization of the targets of altered miRNAs genes may elucidate molecular mechanisms involved in the pathogenesis of pituitary adenoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4235221 Tue, 07 Dec 2010 00:00:00 +0100 4235221 http://www.medworm.com/index.php?rid=4193905&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F72 Conclusions: these data suggested that expression of p53 and mdm-2 in primary and recurrent MEC correlates with the high histological grade. P53 aberrant expression is not only considered as an early event in MEC carcinogenesis but also correlates to tumor behavior and local recurrence. Mdm-2 overexpression is correlated to pathogenesis of MEC. However, no strong evidence was found between mdm-2 expression and MEC local recurrence. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4193905 Mon, 22 Nov 2010 00:00:00 +0100 4193905 http://www.medworm.com/index.php?rid=4193904&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F73 Conclusions: We are confident, and have showed as well, that digital slides have got numerous advantages over optical slides and are more suitable in education. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4193904 Mon, 22 Nov 2010 00:00:00 +0100 4193904 http://www.medworm.com/index.php?rid=4193903&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F74 Conclusions: These results show that the change in sialylation occurs before cancer development and may play an important role in cellular transformation. These findings provide the basis for more detailed studies of the possible role of cell surface glycoconjugates bearing sialic acid in the cellular cervix transformation. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4193903 Mon, 22 Nov 2010 00:00:00 +0100 4193903 http://www.medworm.com/index.php?rid=4180775&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F71 In virtual microscopy, a sequential process of captures of microscopical fields, allows to construct a virtual slidewhich is visualized using a specialized software, called the virtual microscopy viewer. This tool permits usefulexploration of images, composed of thousands of microscopical fields of view at different levels of magnification,emulating an actual microscopical examination. The aim of this study was to establish the main pathologist'snavigation patterns when exploring virtual microscopy slides, using a graphical user interface adapted to thepathologist's workflow. Four pathologists with a similar level of experience, graduated from the same pathologyprogram, navigated six virtual slides. Different issues were evaluated, namely, the percentage of common visitedimage regions, the... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=4180775 Thu, 18 Nov 2010 00:00:00 +0100 4180775