MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Diagnostic Pathology' source. Sat, 13 Mar 2010 15:04:36 +0100 http://www.medworm.com/index.php?rid=3356744&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F17 The presence of ectopic breast tissue in axillary lymph nodes (ALN) is a benign condition that must be differentiated from primary or metastatic carcinoma. Here we report a patient who underwent excision of enlarged ALN 10 years after she had received surgical treatment of ipsilateral breast for an intracystic intraductal papilloma (IDP). Histological examination of the removed ALN revealed that the proliferative lesion consisted of papillary and tubular structures lined by luminal cuboidal cells and a distinct outer layer of myoepithelial cells resembling IDP of the breast. Immunostaining with a set of immunohistochemical markers including AE/AE3, alpha-smooth muscle actin and p63 in combination with estrogen and progesterone receptors confirmed the diagnosis of ectopic IDP.This case show... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3356744 Fri, 12 Mar 2010 00:00:00 +0100 3356744 http://www.medworm.com/index.php?rid=3320171&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F16 Conclusion: MEST represents a distinctive benign tumour entity of the kidney, which affects perimenopausal woman. The tumour should be distinguished from other cystic renal neoplasms. By imaging studies it is difficult to distinguish between a benign or malignant nature of the tumour. Thus, intraoperative frozen section is necessary for conservative surgery, since the overall prognosis is favourable and renal function can be preserved in most cases. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3320171 Mon, 01 Mar 2010 00:00:00 +0100 3320171 http://www.medworm.com/index.php?rid=3304733&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F15 We report a rare case of ostial plication as a potential cause of sudden death. Very few reports and images are available in the specialized literature regarding this anomaly. Ostial plication may be a source of sudden death or cause of death when no other significant autopsy findings are present.Ostial plication is a congenital severe obstruction/occlusion of the right or left ostium. Plication of the aortic wall leads to a "valve-like" ridge that can act as a door blocking inflow during diastolic filling, with consequent ischemia and a potentially life-threatening arrhythmia. The true incidence of this condition and its relationship to sudden death have not been reported in the literature.We believe that this case will be useful to autopsy pathologists in detecting this infrequent anomal... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3304733 Thu, 25 Feb 2010 00:00:00 +0100 3304733 http://www.medworm.com/index.php?rid=3300302&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F14 Conclusions: In the present case, at least some of ONCs seem to form the microaggregates of tumor cells in lymph nodes, anchor in the sinuses, and grow up to the large tumorous lesion. Even if most of the ONCs were trapped and disappeared under the influence of tumor immunity, the detection of ONCs could be one of the reliable clues to estimate the prognosis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3300302 Wed, 24 Feb 2010 00:00:00 +0100 3300302 http://www.medworm.com/index.php?rid=3281710&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F13 Conclusions Although our study provides additional evidence of the potential prognosticrole of c erbB 2, further prospective and controlled studies are required to validate theirclinical usefulness. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3281710 Thu, 18 Feb 2010 00:00:00 +0100 3281710 http://www.medworm.com/index.php?rid=3256987&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F12 Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal neoplasm originating from smooth muscle cells and myofibroblasts. It is characterized with spindle cells, amianthoid fibers, and proliferation of hemosiderin containing histiocytes in the lymph node. The nodular lesion determined in the inguinal region of a 80-year-old male patient was excised. Macroscopic examination of the section of the lesion demonstrated a solid appearance with hemorrhagic areas. Microscopic examination revealed spindle cell proliferation, amianthoid fibers, hemosiderin pigment, and extravasated erythrocytes. Nuclei of the spindle cells displayed a palisaded patchy appearance. Compressed lymphoid tissue was observed around the lesion. By trichrome (Masson) reaction, spindle cells showed staining in sm... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3256987 Tue, 09 Feb 2010 00:00:00 +0100 3256987 http://www.medworm.com/index.php?rid=3222168&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F11 We describe a case of primary carcinosarcoma of the lung concurrently occurring with invasive pulmonary aspergillosis in a 66-year old patient. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3222168 Fri, 29 Jan 2010 00:00:00 +0100 3222168 http://www.medworm.com/index.php?rid=3214627&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F10 In carcinoma tissues, genetic and metabolic changes not only occur at the tumor cell level, but also in the surrounding stroma. This carcinoma-reactive stromal tissue is heterogeneous and consists e.g. of non-epithelial cells such as fibroblasts or fibrocytes, inflammatory cells and vasculature-related cells, which promote carcinoma growth and progression of carcinomas. Nevertheless, there is just little knowledge about the proteomic changes from normal connective tissue to tumor stroma. In the present study, we acquired and analysed specific protein patterns of small stromal sections surrounding head and neck cell complexes in comparison to normal subepithelial connective tissue. To gain defined stromal areas we used laser-based tissue microdissection. Because these stromal areas are limi... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3214627 Thu, 28 Jan 2010 00:00:00 +0100 3214627 http://www.medworm.com/index.php?rid=3210394&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F9 Conclusion: Our findings indicate that these immunomarkers are significantly more expressed in malignant tumors compared to benign lesions and may be of additional diagnostic value when combined with routine histology. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3210394 Tue, 26 Jan 2010 00:00:00 +0100 3210394 http://www.medworm.com/index.php?rid=3199467&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F7 Background: The feasibility of evaluating an objective grading of cervical intraneoplasia lesions ( CIN ) is attempted using an automatic computerized system able to measure several valuable parameters with special reference to epithelium differentiation. Methods: 4 groups of 10 images each were selected at random from 68 consensus images coming from 80 archival cervical biopsies, normal (n=10), CIN 1 (n=10), CIN 2 (n=10), CIN 3 (n=10). Representative images of lesions were captured from the microscopic slides and were analyzed using mathematical morphology, with special reference to Voronoi tessellation and Delaunay triangulation. Epithelium surface, nuclear and cytoplasm area, triangle edge and area, total and upper nuclear index were precisely measured in each lesion, and discriminant c... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3199467 Fri, 22 Jan 2010 00:00:00 +0100 3199467 http://www.medworm.com/index.php?rid=3199466&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F8 Follicular thyroid carcinoma (FTC) tends to metastasize to remote organs rather than local lymph nodes. Separation of FTC from follicular thyroid adenoma (FTA) relies on detection of vascular and/or capsular invasion. We investigated which vascular markers, CD31, CD34 and D2-40 (lymphatic vessel marker), can best evaluate vascular invasion and why FTC tends to metastasize via blood stream to remote organs. Thirty two FTCs and 34 FTAs were retrieved for evaluation. The average age of patients with FTA was 8 years younger than FTC (p = 0.02). The female to male ratio for follicular neoplasm was 25:8. The average size of FTC was larger than FTA (p = 0.003). Fourteen of 32 (44%) FTCs showed venous invasion and none showed lymphatic invasion, with positive CD31 and CD34 staining and negative D2... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3199466 Fri, 22 Jan 2010 00:00:00 +0100 3199466 http://www.medworm.com/index.php?rid=3195943&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F6 The presence of crystalline inclusions in plasma cell myeloma is a rare phenomenon and cases have been reported with rod, needle, and rectangular shaped crystals. Here, we present a case of IgG lambda restricted plasma cell myeloma with rhomboid shaped intracellular crystalline inclusions and extracellular crystal depositions in the bone marrow. Since rhomboid crystal depositions can be seen in other clinical conditions such as pseudogout, this case invites consideration of plasma cell myeloma in the differential diagnosis of patients with rhomboid crystalline deposition in the bone marrow and in sites/organs other than the bone marrow. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3195943 Thu, 21 Jan 2010 00:00:00 +0100 3195943 http://www.medworm.com/index.php?rid=3169530&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F4 A 60-year-old Caucasian male underwent a total pancreatectomy for a mixed type pancreatic intraductal papillary mucinous neoplasm (IPMN) arising in the main and secondary pancreatic ducts. During surgery, a subserosal polypoid mass was noted at the greater curvature of the gastric antrum and was enucleated. This mass was proven to be heterotopic pancreatic tissue with cystic neoplasia of the IPMN histologic subtype. Through an extensive search of the literature, we found that this is the first case ever reported with simultaneous existence of IPMN changes, in the main and secondary ducts of the orthotopic pancreas and in the heterotopic pancreatic tissue of the gastric wall. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3169530 Thu, 14 Jan 2010 00:00:00 +0100 3169530 http://www.medworm.com/index.php?rid=3169529&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F5 Conclusion: Such a pigmented variant of benign oncocytic lesion is very rare, and only 15 cases have been reported in the English literature. As a benign mimicker of malignant melanoma, melanocytic oncocytic metaplasia should be always taken into consideration in the clinical setting. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3169529 Thu, 14 Jan 2010 00:00:00 +0100 3169529 http://www.medworm.com/index.php?rid=3169531&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F3 Conclusion: The Pathwork TOO Test reduced diagnostic uncertainty in all CUP cases and could be a valuable addition or alternative to current diagnostic methods for classifying uncertain primary cancers. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3169531 Wed, 13 Jan 2010 00:00:00 +0100 3169531 http://www.medworm.com/index.php?rid=3155045&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F5%2F1%2F1 We report a case of fatal necrotic pneumonia caused by combined pulmonary invasive mucormycosis and aspergillosis in a 66 year-old renal transplant recipient. Aspergillus was first identified during the course of the disease by cytological examination and culture (A. fumigatus) of bronchoalveolar fluid. Hyphae of Mucorales (Rhizopus microsporus) were subsequently identified by culture of a tissue specimen taken from the left inferior pulmonary lobe, which was surgically resected two days before the patient died. Histological analysis of the lung parenchyma showed the association of two different filamentous mycoses for which the morphological features were evocative of aspergillosis and mucormycosis. However, the definitive identification of the associative infection was made by polymerase... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3155045 Fri, 08 Jan 2010 00:00:00 +0100 3155045 http://www.medworm.com/index.php?rid=3113337&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F47 Editorial: The journey of Diagnostic Pathology in 2009, perspectives for 2010 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3113337 Tue, 22 Dec 2009 00:00:00 +0100 3113337 http://www.medworm.com/index.php?rid=3094596&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F46 Background: Primary open-angle glaucoma (POAG) is the most common form of glaucoma which is an irreversible blind leading disease and lacks effective remedies. In recent years, POAG has been linked to the gene MYOC encoding myocilin that has been identified to harbor causal mutations. A variety of studies show that the mutant myocilin acts by gain of function. The mutant MYOC protein induces endoplasmic reticulum (ER) stress and the resultant unfolded protein response (UPR) induces apoptosis in the trabecular meshwork cells, which then leads to an increase in resistance to aqueous humor outflow, elevated intraocular pressure (IOP), and, ultimately, glaucoma. Culturing human trabecular meshwork (HTM) cells at a condition facilitating protein folding promotes secretion of mutant myocilin, no... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3094596 Wed, 16 Dec 2009 00:00:00 +0100 3094596 http://www.medworm.com/index.php?rid=3073635&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F44 Conclusions: Our case demonstrates a pericardial mesothelioma initially masquerading grossly as pericarditis. Microscopic examination of any grossly abnormal pericardial tissue therefore may be warranted so that a neoplastic disease process does not go undetected. Additionally, of the approximately 200 such tumors reported in the medical literature, a case demonstrating marked hemopericardium and resulting in sudden death has not been described until now. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3073635 Wed, 09 Dec 2009 00:00:00 +0100 3073635 http://www.medworm.com/index.php?rid=3073634&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F45 We report a case of embolism of the sclerosant dye with subsequent formation of foreign-body giant cell reaction within the veins of pulmonary and portal circulation in an autopsy case of hepatocellular carcinoma developing over an underlying primary biliary cirrhosis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3073634 Wed, 09 Dec 2009 00:00:00 +0100 3073634 http://www.medworm.com/index.php?rid=3058644&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F42 We report a rare case of localized mesenteric Castleman's disease, presenting as intestinal obstruction. Clinical and radiological findings were suspicious for lymphoma. Localized mesenteric Castleman's disease, though rare, has to be considered in the differential diagnosis of mesenteric tumors, particularly in the young and in the absence of history for other tumor, an abnormal blood picture, or splenomegaly. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3058644 Fri, 04 Dec 2009 00:00:00 +0100 3058644 http://www.medworm.com/index.php?rid=3024933&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F41 Background: Different molecular alterations have been described in endometrioid endometrial carcinoma (EECA). Among them the most frequently altered is loss of the PTEN protein, a tumor suppressor gene. The purpose of this study was to evaluate the expression pattern of PTEN gene in normal, hyperplastic and neoplastic endometrium. Methods: In a prospective study in a referral gynecologic hospital in Tehran, Iran,immunohistochemical (IHC) evaluation of PTEN was performed on 87 consecutivespecimens to the following three groups; group A- normal proliferative endometrium(n=29); group B- hyperplastic endometrium [including simple hyperplasia without atypia(n=21) and complex hyperplasia with atypia (n=8)] and group C- EECA(n=29). Immunostaining of cells was analyzed by arbitrary quantitative me... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3024933 Wed, 25 Nov 2009 00:00:00 +0100 3024933 http://www.medworm.com/index.php?rid=3021242&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F39 Conclusions: MTHFR C677T polymorphism increased the risk of HCC in an overdominant model, and might be a risk factor for HCC occurrence, especially in CLD patients. The association warranted further studies. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3021242 Tue, 24 Nov 2009 00:00:00 +0100 3021242 http://www.medworm.com/index.php?rid=3021241&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F40 We present a case report of a man under the influence of cocaine and methamphetamine employing a car antenna to cause self-inflicted, intraoral penetrating trauma to the cervical spine and right vertebral artery, resulting in exsanguination and his subsequent death. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3021241 Tue, 24 Nov 2009 00:00:00 +0100 3021241 http://www.medworm.com/index.php?rid=2983385&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F37 In this report, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma. Pathological assessment on a pre-operative bioptical specimen showed an immature teratoid tumor with no area of hepatoblastic differentiation present. Histological and immunhistological examination of the resected tumor specimen additionally showed tumor areas of very different differentiation pattern intermixed with each other, namely areas of hepatoblastoma-typical and neuroblastoma-like morphology as well a areas of rhadomyosarcomatous differentiation.After chemotherapy the tumor size increased and an extended right hemihepatectomy was performed. Post-operatively, the general condition of t... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2983385 Thu, 12 Nov 2009 00:00:00 +0100 2983385 http://www.medworm.com/index.php?rid=2957132&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F36 Conclusions: Our data strengthen the usefulness of 7q31 region evaluation to discriminate EGFR amplification from chromosome 7 polysomy in controversial EGFR FISH positive cases. Since it has been reported a possible different contribution of amplification and polysomy to TKIs susceptibility in NSCLC, the clear distinction between these two genetic events may be important to identify a subset of patients more responsive to the therapy. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2957132 Wed, 04 Nov 2009 00:00:00 +0100 2957132 http://www.medworm.com/index.php?rid=2892721&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F35 Conclusion:This is the first study in the literature to use DIHC of p53+CK20 in distinction of non-neoplastic and neoplastic bladder lesions. Dual staining by p53+CK20 cocktail allows for histologic correlation and diminishes the risk of losing the area of interest in limited biopsy specimens. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2892721 Tue, 13 Oct 2009 23:00:00 +0100 2892721 http://www.medworm.com/index.php?rid=2833542&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F33 Conclusion: These cases are the first from South America to be reported, and they are about an idiopathic renal disease that is not related to any specific races or locations. The reports contribute to a better understanding of this disease, which although not so prevalent, should be considered as an importantly differential diagnostic of cases of proteinuria. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2833542 Thu, 24 Sep 2009 23:00:00 +0100 2833542 http://www.medworm.com/index.php?rid=2822540&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F32 Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands. About 90% of these tumors occur in the parotid gland and 10% in the minor salivary glands. The most common sites of pleomorphic adenoma of the minor salivary glands are the palates followed by lips and cheeks. Other rare sites include the throat, floor of the mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity. In children, intraoral pleomorphic adenomas of the cheek are extremely rare with only three cases reported to date. Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 17-year-old girl. The mass was removed by wide local excision with adequate margins, and after a follow-up period of three years there were no recurrences. To conclude,... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2822540 Mon, 21 Sep 2009 23:00:00 +0100 2822540 http://www.medworm.com/index.php?rid=2760341&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F30 We report a breast cylindroma in a previously healthy 62 year old female detected through a national breast screening program. The patient had no significant family or past medical history, and specifically no history of breast or skin diseases. The tumor consisted of well circumscribed islands of epithelial cells surrounded by a dense membrane material, and focally containing hyaline globules. At low power the islands of tumour cells formed a "jig-saw" pattern, which is typical of cylindroma, but was present within normal breast parenchyma and no had direct connection with the overlying skin. Two distinct cell populations, smaller peripheral basaloid cells and larger central cells with vesicular chromatin, were highlighted by immunohistochemistry for p63 and cytokeratin-7 respectively. Im... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2760341 Tue, 01 Sep 2009 23:00:00 +0100 2760341 http://www.medworm.com/index.php?rid=2750259&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F29 Conclusion: The most common caruncle lesions were epithelial tumors followed by chronic inflammation and melanocytic lesions. Although most of the lesions were benign, there was a great number of misdiagnose based on the clinical suspicious. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2750259 Sun, 30 Aug 2009 23:00:00 +0100 2750259 http://www.medworm.com/index.php?rid=2722240&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F27 Conclusions: Human placenta releases substances that mediate apoptosis and reduce proliferation in tumor tissue and cell culture. As even sterile-filtrated medium caused the mentioned effects we hypothesize one or more soluble mediators. The detailed way of promoting apoptosis and nature of these mediators need to be elucidated in further studies. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2722240 Thu, 20 Aug 2009 23:00:00 +0100 2722240 http://www.medworm.com/index.php?rid=2714398&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F26 In this study, we analyzed a group of intermediate and high-grade DCIS cases to determine how well the core biopsy predicts the maximal pathology in the associated excisions, and to determine if there are any core biopsy morphologic features that may predict a close (less than or equal to 0.2cm) or positive margin in the subsequent excision. Forty-nine consecutive paired specimens [core biopsies with a maximal diagnosis of DCIS, and their corresponding excisions, which included 20 and 29 specimens from mastectomies and breast conserving surgeries respectively] were evaluated in detail. In 5 (10%) of 49 cases, no residual carcinoma was found in the excision. In another 4 cases, the changes were diagnostic only of atypical ductal hyperplasia. There were 4 and 3 respective cases of invasive a... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2714398 Tue, 18 Aug 2009 23:00:00 +0100 2714398 http://www.medworm.com/index.php?rid=2655703&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F25 Conclusion: The origin of ovarian leiomyoma is still unresolved. In our case, the tumor probably arose from smooth muscle cells derived from myofibroblasts that originate from metaplastic ovarian stromal cells present in the rim of the endometriotic cyst. Despite its rarity, ovarian leiomyoma should be considered in the differential diagnosis of ovarian spindle cell tumors. Appropriate diagnosis may require additional immunohistochemical analysis in some cases. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2655703 Wed, 29 Jul 2009 23:00:00 +0100 2655703 http://www.medworm.com/index.php?rid=2596596&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F23 Conclusions In conclusion, PR3-ANCA prime human mononuclear cells to produce cytokines upon stimulation with various microbial components by up-regulating the TLR and NOD signaling pathway, and these mechanisms may partially participate in the inflammatory process in Wegener's granulomatosis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2596596 Mon, 13 Jul 2009 23:00:00 +0100 2596596 http://www.medworm.com/index.php?rid=2582561&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F22 Conclusion: Immunohistochemical analysis of p16INK4a expression is a useful diagnostic tool. Expression is related to the degree of histological dysplasia, suggesting that it may have prognostic and predicative value in the management of cervical neoplasia. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2582561 Wed, 08 Jul 2009 23:00:00 +0100 2582561 http://www.medworm.com/index.php?rid=2549759&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F21 Conclusion: To accurately subclassify renal cell carcinomas, simple ancillary techniques would possibly resolve all difficult cases. The relative incidence of sub-types of renal cell carcinoma is relatively consistent the world over. However, in India, RCCs afflict the patients two decades earlier. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2549759 Sat, 27 Jun 2009 23:00:00 +0100 2549759 http://www.medworm.com/index.php?rid=2493843&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F18 Conclusion: Adenoid cystic carcinomas positive for p-AKT show a higher relapse risk. However, other parameters of glucose metabolism investigated here or proliferation (Ki67) were not predictive in this entity. Our findings demonstrate a possible background for therapeutic approaches targeting the inhibition of PI3K/AKT pathway. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2493843 Thu, 18 Jun 2009 23:00:00 +0100 2493843 http://www.medworm.com/index.php?rid=2493842&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F19 Conclusions: The use of otherwise already widely available technologies, without any need for adaptors or otherwise additional technology, could significantly increase opportunities and quality diagnostics while lowering costs and considerably increasing connectivity between most isolated laboratories and distant reference center. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2493842 Thu, 18 Jun 2009 23:00:00 +0100 2493842 http://www.medworm.com/index.php?rid=2481645&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F17 Conclusion: This unique and first case herein presented with synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney emphasizes the need for thorough sectioning and entire submission for histologic evaluation of mature cystic teratomas, in order to avoid missing multiple additional histogenetically distinct neoplasms. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481645 Sun, 14 Jun 2009 04:00:00 +0100 2481645 http://www.medworm.com/index.php?rid=2461299&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F16 Conclusion: This is the sixth case of lipomatous pleomorphic adenoma in the English literature. Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management. On CT scan, it may not be detected possibly due to the extensive fatty component. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2461299 Thu, 04 Jun 2009 04:00:00 +0100 2461299 http://www.medworm.com/index.php?rid=2420172&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F15 The recently recognized renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children. They comprise at least one-third of pediatric RCCs and only few adult cases have been reported. Here, we present a case of Xp11.2 translocation RCC in 26-year-old pregnant female. Her routine antenatal ultrasonography accidentally found a complex cystic right renal mass. Further radiologic studies revealed unilocular cyst with multiple mural nodules at inferior pole of right kidney, which was suspicious for RCC. She underwent right radical nephrectomy at 15 weeks gestation. Macroscopically, the cystic tumor was well encapsulated with multiple friable mural nodules on its inner surface. Microscopically, the tu... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2420172 Mon, 18 May 2009 04:00:00 +0100 2420172 http://www.medworm.com/index.php?rid=2420173&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F14 Conclusions: Mdm-2 played a tumor-suppressor role that might be implicated with the benign behavior of Warthin's tumor. The mutual expression of both p27Kip1 and bcl-2 suggested a protective role of these slowly proliferating cells from apoptosis to maintain their survival and elevated bcl-2 expression offers a significant protection against p27Kip1-mediated apoptosis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2420173 Sat, 16 May 2009 04:00:00 +0100 2420173 http://www.medworm.com/index.php?rid=2361644&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F13 Bronchoalveolar lavage (BAL) is a useful diagnostic tool in interstitial lunge diseases (ILD). However, differential cell counts are often non specific and immunocytochemistry is time consuming. Staining of glyoproteins by periodic acid Schiff (PAS) reaction may help in discriminating different forms of ILD. In addition, PAS staining is easy to perform. BAL cells from patients with idiopathic pulmonary fibrosis (IPF) (n = 8), sracoidosis (n = 9), and extrinsic allergic alveolitis (EAA) (n = 2) were investigated. Cytospins from BAL cells were made and cells were stained using Hemacolor quick stain and PAS staining. Lymphocytic alveolitis was found in sarcoidosis and EAA whereas in IPF both lymphocytes and neutrophils were increased. PAS positive cells were significantly decreased in EAA com... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2361644 Thu, 23 Apr 2009 04:00:00 +0100 2361644 http://www.medworm.com/index.php?rid=2335977&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F12 Pattern recognition receptors are a key component of the first line host defense against infection, recognizing specific microbial products. We hypothesize that monocyte hyporesponsiveness in human sepsis is associated with a downregulation of the pattern recognition receptors Toll-like receptor (TLR)-2 and TLR4. Protein expression of CD14, TLR2 and TLR4 on blood monocytes was examined using flow cytometry from 29 patients with sepsis and 14 healthy controls. In addition LPS stimulated TNF-alpha and IL-10 production was studied in a 24 hour whole blood assay. We found an increased expression of CD14, TLR2 and TLR4 in patients with sepsis compared to controls (p (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2335977 Thu, 16 Apr 2009 04:00:00 +0100 2335977 http://www.medworm.com/index.php?rid=2315358&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F11 Conclusion: Primary ALK negative ALCL arising at the site of saline filled breast implant is rare. It is still unclear whether chemotherapy and breast implantation increases risk of secondary hematological malignancies significantly. However, it is important to be aware of these complications and need for careful pathologic examination of tissue removed for implant related complications to make the correct diagnosis for further patient management and treatment. It is important to be aware of this entity at this site as it can be easily misdiagnosed on histologic grounds and to exclude sarcomatoid carcinoma, malignant melanoma and pleomorphic sarcoma by an appropriate panel of immunostains to arrive at the correct diagnosis of ALCL. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2315358 Thu, 02 Apr 2009 04:00:00 +0100 2315358 http://www.medworm.com/index.php?rid=2291026&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F10 Conclusion: It may be necessary to make some revisions in WHO classification for endometrial hyperplasia and precancerous lesions. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2291026 Wed, 25 Mar 2009 04:00:00 +0100 2291026 http://www.medworm.com/index.php?rid=2291027&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F9 Conclusion: Our data demonstrated that although the GTC technique has yielded a higher amount of RNA, the SGC technique was much more superior with respect to the reliable generation of an intact RNA and effectively amplified longer products in fresh as well as in frozen tissues. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2291027 Tue, 24 Mar 2009 04:00:00 +0100 2291027 http://www.medworm.com/index.php?rid=2265540&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F8 This article gives an overview about the state of knowledge on SP-A focused in applications for human pulmonary disorders and points out the importance for pathology-orientated research approaches using immunohistochemistry or in situ hybridization as promising methods to further elucidate the role of this molecule in adult lung diseases. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2265540 Thu, 12 Mar 2009 04:00:00 +0100 2265540 http://www.medworm.com/index.php?rid=2226804&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F4%2F1%2F7 Conclusion: For the first time the prognostic impact of caspase-8 and p-p38 was studied in a series of ccRCCs, using immunohistochemistry in formalin-fixed and paraffin-embedded tissue sections. The suggestive relationship of caspase-8 with patients' clinical outcome, as well as the role of p-p38 within different grade categories, mandates further studies in larger cohorts of RCCs. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2226804 Tue, 17 Feb 2009 05:00:00 +0100 2226804 http://www.medworm.com/index.php?rid=2089561&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F49 Light emitting diodes (LED), which are available as small monochromatic light sources with characteristic features such as maximum illumination power combined with minimum energy consumption and extremely long lifespan have already proved as a highly potential low-cost alternative for specific diagnostic applications in clinical medicine such as tuberculosis fluorescence microscopy. Likewise, the most reliable evaluation of Her-2/neu (c-erbB2) gene amplification, which has been established in the last few years for routine diagnosis in clinical pathology as determinant towards Herceptin-based treatment of patients with breast cancer, is based on fluorescence in situ hybridization (FISH) and corresponding high priced fluorescence equipment. In order to test the possibility to utilize the ad... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2089561 Tue, 16 Dec 2008 05:00:00 +0100 2089561 http://www.medworm.com/index.php?rid=2039397&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F48 Nearly three years have passed since the first issue of our journal Diagnostic Pathology had been accessible via our open access publisher BiomedCentral. About 150 scientific articles have been published since then. Therefore, we want to express our deep gratitude to all authors who submitted their articles. They took into account two constraints, namely paying a publication fee, and, in addition, knowing that our journal has not yet been included into the citation index list. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2039397 Tue, 16 Dec 2008 05:00:00 +0100 2039397 http://www.medworm.com/index.php?rid=2039396&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F49 Light emitting diodes (LED), which are available as small monochromatic light sources with characteristic features such as maximum illumination power combined with minimum energy consumption and extremely long lifespan have already proved as a highly potential low-cost alternative for specific diagnostic applications in clinical medicine such as tuberculosis fluorescence microscopy. Likewise, the most reliable evaluation of Her-2/neu (c-erbB2) gene amplification, which has been established in the last few years for routine diagnosis in clinical pathology as determinant towards Herceptin-based treatment of patients with breast cancer, is based on fluorescence in situ hybridization (FISH) and corresponding high priced fluorescence equipment. In order to test the possibility to utilize the ad... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2039396 Tue, 16 Dec 2008 05:00:00 +0100 2039396 http://www.medworm.com/index.php?rid=1989742&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F46 Background: The chance of an intrathyroidal localization of a parathyroid gland is about 1-3%. Among the causes of hyperparathyroidism, parathyroid carcinomas occur in less than 1% of patients. Hence, the probability of a parathyroid carcinoma to be intrathyroidal is less than 0.01% of all cases of hyperparathyroidism. Although parathyroid adenoma and carcinoma have disparate natural history, it can be difficult to differentiate between the two entities. Clinical presentation and operative findings may raise suspicion, but may not be conclusive, if there is no evidence of invasion or metastasis, and especially, if the parathyroid gland is intrathyroidal (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1989742 Tue, 25 Nov 2008 05:00:00 +0100 1989742 http://www.medworm.com/index.php?rid=1938427&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F43 Conclusions: FCI is a sensitive and specific method in diagnosis and classification of NHL as well as in detection of monoclonality. False negative results could be due to the presence of heterogeneous populations of lymphocytes in special types of lymphoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1938427 Thu, 06 Nov 2008 05:00:00 +0100 1938427 http://www.medworm.com/index.php?rid=1938426&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F44 Conclusions: These results show that virtual karyotypes generated by SNP arrays can be used as a practical ancillary study for the classification of renal epithelial tumors with complex or ambiguous morphology. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1938426 Thu, 06 Nov 2008 05:00:00 +0100 1938426 http://www.medworm.com/index.php?rid=1905276&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F42 Conclusion: To our best knowledge this is the first case reported of mucinous male breast cancer presenting as Paget disease of the nipple. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1905276 Fri, 24 Oct 2008 04:00:00 +0100 1905276 http://www.medworm.com/index.php?rid=1900852&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F41 Conclusions: Automated BDISH applications for HER2 and CEN 17 targets were successfully developed and it might be able to replace manual two-color HER2 FISH methods. The application also has the potential to be used for other gene targets. The use of BDISH technology allows the simultaneous analyses of two DNA targets within the context of tissue morphological observation. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1900852 Wed, 22 Oct 2008 04:00:00 +0100 1900852 http://www.medworm.com/index.php?rid=1805982&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F39 We report an analysis of 20 cases of ovarian involvement by metastatic colorectal adenocarcinomas and colorectal involvement by metastatic ovarian adenocarcinomas, including the value of differential expression of cytokeratins 7 & 20 by immunohistochemistry (IHC), in these cases. Nine cases (45%) were identified as colorectal adenocarcinomas metastatic to the ovary. On biopsy, all these cases showed a 'garland-like' tumor necrosis, with desmoplasia and predominantly exhibited a tubuloalveolar pattern (67% cases). On IHC, all 8 of 9 such cases, where staining for cytokeratin 20 was performed, displayed strong positivity and 7 cases, where staining for carcinoembryogenic antigen (CEA) was performed, revealed positivity for this marker (100%). Other 11 cases (55%) were ovarian adenocarcinomas... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1805982 Thu, 18 Sep 2008 04:00:00 +0100 1805982 http://www.medworm.com/index.php?rid=1738729&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F35 In several tumors the transketolase activity, controlled inter alia by enzymes of the pentose phosphate pathway which is an alternative, energy generating reaction-cascade to glycolysis, has been correlated with proliferation. The increase of thiamine-dependant transketolase enzyme reactions is induced especially through upregulated transketolase-like enzyme 1 (TKTL1)-activity; that shows TKTL1 to be a causative enzyme for tumors enhanced, anaerobic glucose degradation. We investigated TKTL1-expression in 88 human, formalin-fixed non-small cell lung cancer tissues and 24 carcinomas of the breast by immunohistochemical stainings applying a 0 to 3 staining-score system (3 = strongest expression). For means of validation we additionally stained 40 NSCLC fixed and paraffin-embedded utilizing t... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1738729 Tue, 12 Aug 2008 04:00:00 +0100 1738729 http://www.medworm.com/index.php?rid=1700239&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F34 A 62-year-old male presented with symptoms of urinary obstruction and elevated serum prostate-specific antigen level of 3.61 ng/mL. Prostate needle biopsies showed benign prostatic tissue with a focus of crowded glands with minimal cytological atypia, fairly well-circumscribed with infiltrative appearance of glands at the edges. This focus had both small and larger glands with similar histological features. This focus was strongly positive for alpha-methylacyl-coenzyme A-racemase (AMACR), but showed scattered patchy staining with basal cell markers (p63 and CK903/34betaE12). Hence, the final histologic diagnosis was benign prostatic tissue with a focus of florid adenosis. Two subsequent follow-up prostate needle biopsies performed six and 12 months later both showed benign prostatic tissue... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1700239 Tue, 12 Aug 2008 04:00:00 +0100 1700239 http://www.medworm.com/index.php?rid=1700238&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F35 In several tumors the transketolase activity, controlled inter alia by enzymes of the pentose phosphate pathway which is an alternative, energy generating reaction-cascade to glycolysis, has been correlated with proliferation. The increase of thiamine-dependant transketolase enzyme reactions is induced especially through upregulated transketolase-like enzyme 1 (TKTL1)-activity; that shows TKTL1 to be a causative enzyme for tumors enhanced, anaerobic glucose degradation. We investigated TKTL1-expression in 88 human, formalin-fixed non small cell lung cancer tissues and 24 carcinomas of the breast by immunohistochemical stainings applying a 0 to 3 staining-score system (3 = strongest expression). For means of validation we additionally stained a 40 NSCLC fixed and paraffin-embedded utilizing... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1700238 Tue, 12 Aug 2008 04:00:00 +0100 1700238 http://www.medworm.com/index.php?rid=1671114&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F33 We present their histories along with relevant radiological, microscopic and immunohistochemical features, followed by a discussion of this unusual pathological entity. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1671114 Fri, 01 Aug 2008 04:00:00 +0100 1671114 http://www.medworm.com/index.php?rid=1525516&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F27 In this short report we illustrate a case of extensive sodium polystyrene sulfonate (SPS) aspiration as an immediate cause of death in a terminally ill patient. SPS is a cation exchange resin utilized to decrease potassium levels in patients with renal failure. When administered rectally in conjunction with sorbitol, colonic necrosis and perforation have been documented. On the other hand, oral administration can be complicated by aspiration, especially in very ill or debilitated patients. In our current report, histological examination of a patient who aspirated SPS shows multiple polygonal to amorphous basophilic crystalline particles deposited intraalveolarly. The purpose of our report is to familiarize pathologists with the histologic features of this rare iatrogenic complication of th... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1525516 Tue, 17 Jun 2008 04:00:00 +0100 1525516 http://www.medworm.com/index.php?rid=1477634&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F22 Conclusion: ALHE with molecular evidence of monoclonality is extremely unusual, as is the association with nodal peripheral T-cell nodal lymphoma. The findings of this case support our hypothesis that ALHE might be an early form of T-cell lymphoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1477634 Thu, 29 May 2008 04:00:00 +0100 1477634 http://www.medworm.com/index.php?rid=1409459&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F21 Conclusion: The diagnosis of parvovirus should be considered in cases of fatal myocarditis, and diagnosis can be confirmed at autopsy by molecular techniques. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1409459 Wed, 30 Apr 2008 04:00:00 +0100 1409459 http://www.medworm.com/index.php?rid=1406634&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F20 This short report discusses a case of solitary colonic polypoid ganglioneuroma associated with melanosis coli in a woman with no systemic manifestations. To our knowledge this is the first ganglioneuroma reported in the literature in association with melanosis coli. The nature and significance of this event remains unclear, although this may be coincidental due to the laxative intake.Further investigation is necessary to clarify this point. The interest of this case lies moreover in the rarity of this entity and its endoscopic and histologic resemblance to sessile polyps frequent in the clinical practice. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1406634 Tue, 29 Apr 2008 04:00:00 +0100 1406634 http://www.medworm.com/index.php?rid=1403941&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F19 DiscussionConsidering the association of hepatitis with the Epstein-Barr virus in later life, it is likely that EBV hepatitis and its complications occur in the neonatal/perinatal period. Since EHBA is a relatively rare disease, a similar study on wedge biopsies of this number of proven cases of EHBA has not been performed to date. Current observation proposes the need for a study of larger series and employing other methods for confirming the etiologic role of EBV in EHBA cases. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1403941 Mon, 28 Apr 2008 04:00:00 +0100 1403941 http://www.medworm.com/index.php?rid=1382183&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F16 Conclusions: CLL demonstrates enhanced angiogenesis, with increased MVD, upregulated VEGF and downregulated TSP-1. Upregulation of HIF-1a in all CLL cases suggests localized tissue hypoxia as an important stimulant of microvessel proliferation. The presence of VEGF receptors on CLL cells implies an autocrine effect for VEGF. Differences in MVD did not correlate with traditional genetic/immunophenotypic markers of aggressiveness. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1382183 Fri, 18 Apr 2008 04:00:00 +0100 1382183 http://www.medworm.com/index.php?rid=1382182&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F17 Conclusion: The progress in virtual microscopy and application of artificial intelligence (AI) in tissue-based diagnosis demands fast preparation and implementation of an internationally acceptable standard. The described hierarchic order as well as analytic investigation in all potentially necessary aspects and details offers an appropriate tool to specifically determine standardized requirements. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1382182 Fri, 18 Apr 2008 04:00:00 +0100 1382182 http://www.medworm.com/index.php?rid=1376501&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F14 We present three cases of common intracranial tumors, with purely extracranial extension. The three described cases demonstrate, that preoperative MRI and CT imaging is important for differential diagnosis to exclude intracranial connections of the tumors. A definitive diagnosis requires specialized immunohistochemical examinations. In all cases of intranasal or pharyngeal neoplasm the diagnosis of meningioma, craniopharyngeoma and glioma should be considered as differential diagnosis to optimize the surgical procedure. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1376501 Wed, 16 Apr 2008 04:00:00 +0100 1376501 http://www.medworm.com/index.php?rid=1376500&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F15 Conclusion: Although the incidence of pleomorphic liposarcoma in the foot is very low, it is essential to perform thorough histological analysis of all soft tissue masses, regardless of their benign appearance, because only prompt radical surgery can result in a good prognosis for the patient. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1376500 Wed, 16 Apr 2008 04:00:00 +0100 1376500 http://www.medworm.com/index.php?rid=1328798&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F13 Conclusion: Distinction between clinically benign lymphoid proliferations related to antipsoriasis therapy and malignant lymphoma avoids the unnecessary use of anti-lymphoma chemotherapy. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1328798 Wed, 26 Mar 2008 04:00:00 +0100 1328798 http://www.medworm.com/index.php?rid=1313919&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F12 Conclusion: The true incidence and importance of age- and exercise-associated myocardial fibrosis is an area for future research. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1313919 Wed, 19 Mar 2008 04:00:00 +0100 1313919 http://www.medworm.com/index.php?rid=1300149&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F11 Conclusions: The key differentiating point rests in distinguishing the aforementioned mass forming lesion from the myxoid subtype of low-grade leiomyosarcoma in order to avoid unnecessary radical therapy (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1300149 Thu, 13 Mar 2008 04:00:00 +0100 1300149 http://www.medworm.com/index.php?rid=1280585&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F10 DiscussionDespite findings of previous studies, we have shown that CD56 staining can not help as an ancillary test in differential diagnosis of neonatal cholestasis and perhaps other markers should be tested in this regard. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1280585 Wed, 05 Mar 2008 05:00:00 +0100 1280585 http://www.medworm.com/index.php?rid=1264982&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F9 Conclusion: DPLN with SCN is a rare entity with poor prognosis, which may be overlooked and needs aggressive management. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1264982 Thu, 28 Feb 2008 05:00:00 +0100 1264982 http://www.medworm.com/index.php?rid=1217775&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F6 In this commentary, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable aclear cell EmGDa that probably represents a precancerous lesion to endometrial clear cell carcinomas. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1217775 Fri, 08 Feb 2008 05:00:00 +0100 1217775 http://www.medworm.com/index.php?rid=1217774&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F7 Conclusion: The role of fine needle aspiration in the diagnosis of mammary myoepithelial carcinoma, in this case, was to establish malignancy rather than to arrive at a specific diagnosis, as a number of different entities potentially can mimic this neoplasm on cytologic specimens. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1217774 Fri, 08 Feb 2008 05:00:00 +0100 1217774 http://www.medworm.com/index.php?rid=1211889&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F5 Papillary carcinoma of the thyroid (PTC) is the commonest thyroid cancer. In the recent decades an obvious increase in the incidence of PTC has occurred. The pathological diagnosis of PTC is usually an easy diagnosis in the majority of cases. However since the introduction of follicular variant of PTC and the wide threshold range in interpretation of the clearly set pathological criteria for diagnosis of PTC, between pathologists including experts, the diagnosis in some cases became quite difficult. Unfortunately some cases are unjustifiably over-called as follicular variant of PTC as a result of the wide inter observable variability between pathologists, including thyroid pathologists. Ancillary studies such as immmunohistochemistry may be helpful, but till now there is no 100% consisten... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1211889 Wed, 06 Feb 2008 05:00:00 +0100 1211889 http://www.medworm.com/index.php?rid=1185550&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F3 The presence of pancreatic islets alone in the peripancreatic region and splenic hilum is an uncommon occurrence. Herein, we describe their presence in this rare location. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1185550 Tue, 29 Jan 2008 05:00:00 +0100 1185550 http://www.medworm.com/index.php?rid=1145700&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F2 Conclusion: Melanotic medullary carcinoma is an extremely uncommon entity. There is a need to report more number of cases in the literature for exact categorization and prognostication of this subtype of medullary carcinoma. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1145700 Fri, 11 Jan 2008 05:00:00 +0100 1145700 http://www.medworm.com/index.php?rid=1130708&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F3%2F1%2F1 - (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1130708 Fri, 04 Jan 2008 05:00:00 +0100 1130708 http://www.medworm.com/index.php?rid=1111384&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F51 Background: Many terminologies have been given to dysplastic hepatocellular nodules, which are preneoplastic lesions. In 1995, the International Working Party meeting established the nomenclature and morphological criteria for hepatocellular nodular lesions. Nevertheless, an unequivocal differential diagnosis is sometimes difficult, particularly among large regenerative nodules, dysplastic nodules and hepatocellular carcinoma. Angiogenesis is observed during hepatocarcinogenesis and the presence of the isolated arteries may help to discriminate these nodules. The relevance of the International Working Party histological variables and presence of the isolated arteries were analyzed with regard to the diagnosis of large regenerative nodules, low and high grade dysplastic nodules and hepatoce... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1111384 Fri, 21 Dec 2007 05:00:00 +0100 1111384 http://www.medworm.com/index.php?rid=1108370&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F50 We report the first case of bilateral CMV oophoritis diagnosed in surgical resection specimens from a 63-year-old woman with metastatic brain lesions undergoing whole brain radiation and steroid treatment. The ovarian involvement of CMV infection was an incidental finding during the colectomy and bilateral salpingo-oophorectomy procedure for gastrointestinal bleeding and presumed ovarian metastases. In contrast to the prevailing dogma, a review of the literature found similar prevalence of pre-menopausal and post-menopausal cases. While age related vasculopathy was thought to be the prevailing mechanism for CMV oophoritis, the observation of an inflammation mediated microthrombosis in our case provides a plausible age independent mechanism suggesting that both restrictive and obstructive v... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1108370 Thu, 20 Dec 2007 05:00:00 +0100 1108370 http://www.medworm.com/index.php?rid=1105966&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F49 Conclusion: This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1105966 Wed, 19 Dec 2007 05:00:00 +0100 1105966 http://www.medworm.com/index.php?rid=1067040&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F45 Conclusion: The findings indicate that despite the small number of reported cases, PEComas-NOS should be considered tumors of uncertain malignant potential, and metastases to other organs might become evident even several years after the primary diagnosis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1067040 Mon, 03 Dec 2007 05:00:00 +0100 1067040 http://www.medworm.com/index.php?rid=1048298&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F44 Conclusions: CMF originating in unusual locations should be distinguished from chondrosarcomas, especially on small biopsies, and should be included in the differential diagnosis. As previously noted in the literature, the cells can be positive for actin but unlike conventional chondroid neoplasms can be negative for S-100. To our knowledge, this is the first report describing a novel chromosomal translocation, t(1;5)(p13;p13) in CMF. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1048298 Sat, 24 Nov 2007 05:00:00 +0100 1048298 http://www.medworm.com/index.php?rid=1012194&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F43 Conclusion: This study confirms the ability of pluripotent precursor cells to differentiate into either adenocarcinoma or neuroendocrine tumor and, justifying the designation of composite exocrine-neuroendocrine cell carcinoma as the appropriate classification for this tumor. The protracted clinical course further supports the notion that composite signet-ring cell/neuroendocrine carcinoma tumors behave relatively less aggressively than the pure forms of the former cell type. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=1012194 Wed, 07 Nov 2007 05:00:00 +0100 1012194 http://www.medworm.com/index.php?rid=994696&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F42 Conclusion: An immunohistochemical panel including CD43, lysozyme, myeloperoxidase (MPO), CD68 (or CD163), CD117, CD3 and CD20 can successfully identify the vast majority of MS variants in formalin-fixed paraffin-embedded tissue sections. The present report expands the spectrum of our knowledge showing that de novo MS has frequent monoblastic differentiation and frequently carries a normal karyotype. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=994696 Wed, 31 Oct 2007 04:00:00 +0100 994696 http://www.medworm.com/index.php?rid=978895&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F40 Conclusions: Squamous differentiation is not well documented in endocervical adenocarcinomas of endometrioid type and, when widespread, may represent a diagnostic pitfall for pathologists. Interpretation of small biopsies from the endocervical canal on the basis of morphology alone may lead to misdiagnosis and inappropriate surgical management. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=978895 Thu, 25 Oct 2007 04:00:00 +0100 978895 http://www.medworm.com/index.php?rid=918826&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F38 Conclusion: In this report we discuss a rare case of metastatic malignant melanoma to the bone marrow with an unknown primary. Clinicians must be aware of the varied clinical manifestations of disseminated malignant melanoma even if the primary site is not evident. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=918826 Tue, 02 Oct 2007 04:00:00 +0100 918826 http://www.medworm.com/index.php?rid=908228&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F37 Conclusions: The PCR assay is able to deal with different materials (blood and FFPE) this means quality and quantity of DNA and can be used for high-througput screening because of its robustness. Moreover, the method is easy-to-use, not labour-intensive, and easy to realise in a standard laboratory. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=908228 Thu, 27 Sep 2007 04:00:00 +0100 908228 http://www.medworm.com/index.php?rid=902633&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F36 Conclusions: Immunohistochemistry using anti- MPT64 is a simple and sensitive technique for establishing an early and specific diagnosis of M. tuberculosis infection and one that can easily be incorporated into routine histopathology laboratories. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=902633 Tue, 25 Sep 2007 04:00:00 +0100 902633 http://www.medworm.com/index.php?rid=843225&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F35 Colorectal small cell carcinoma (SmCC) is a rare tumor with an aggressive course. The aim of this study is to summarize our experience with this tumor and to highlight its immunohistochemical profile. Ten cases of colorectal SmCC were identified in our files and a panel of immunostains was performed. Follow up was available for the average of 3 years, during which 7 patients died and 3 were alive with disease. All cases were positive for LMWK, CK 19 and pancytokeratin but were negative for TTF-1 and CA 125. EGFR was positive in 7 cases. TTF-1 negative staining may be valuable in differentiating it from its pulmonary counterpart. CDX2, mCEA, CD56, synaptophysin, NSE and chromogranin can help differentiate it from non-endocrine poorly differentiated adenocarcinoma. The expression of EGFR in ... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=843225 Wed, 05 Sep 2007 04:00:00 +0100 843225 http://www.medworm.com/index.php?rid=830850&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F33 Conclusion: Only two cases of bile duct carcinoma metastasising to the male genital tract have previously been reported in the literature, the testis being the main site of metastasis in both cases. To our knowledge, this is the first described case of cholangiocarcinoma metastasising primarily to the epididymis, and presenting as a solitary epididymal metastasis in the absence of disseminated disease. It serves to highlight the importance of performing a thorough examination of the male external genitalia both clinically, in the follow up of cancer patients, and at autopsy. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=830850 Thu, 30 Aug 2007 04:00:00 +0100 830850 http://www.medworm.com/index.php?rid=818610&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F32 We report a case of acute lymphoblastic leukemia (ALL) and basal cell carcinoma (BCC) occurring simultaneously in multiple skin sites. Several cases showing an association between cutaneous malignancies and lymphoproliferative disorders have been reported. Some of these cases included ALL and BCC and occurred often in the pediatric population with the BCC arising as a post-ALL therapy sequela. Other rare genetic causes may be considered. To our knowledge this is the first time that the synchronous occurrence of these two malignant processes in the same tissue involving multiple sites in an elderly patient is described. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=818610 Thu, 23 Aug 2007 04:00:00 +0100 818610 http://www.medworm.com/index.php?rid=796889&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F29 We present the case of a 39-year-old male with a tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty to enlarge a post-chemoradiation-induced shrunken bladder. He presented with gross hematuria. Cystoscopy revealed a papillary tumor at the site of ileovesical anastomosis, and transurethral resection was performed. Histologic examination revealed a tubular adenoma with high-grade dysplasia. There are only two previous reports of tubulovillous adenoma in ileal segment after ileocystoplasty, both without high-grade dysplasia. Our observation supports the hypothesis that an ileal neobladder may undergo all the morphologic and molecular changes observed in the development of gastrointestinal adenocarcinoma. Therefore, patients who had an il... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=796889 Mon, 13 Aug 2007 04:00:00 +0100 796889 http://www.medworm.com/index.php?rid=761377&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F27 Conclusion: Fulminant hepatic failure is a medical emergency, proper histological categorization can help in deciding the treatment modalities. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=761377 Fri, 27 Jul 2007 04:00:00 +0100 761377 http://www.medworm.com/index.php?rid=751435&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F26 An 84-year-old woman underwent hysterectomy due to a friable endometrial mass infiltrating almost half way through the myometrial wall. The tumor consisted of papillary structures with thin fibrovascular cores covered by several layers of pleomorphic cells. The deeply located neoplastic cells were ovoid with a pale eosinophilic cytoplasm resembling urothelial cells. A diagnosis of papillary squamous cell carcinoma of the endometrium with transitional cell differentiation was made. Although she recovered well after surgery, she died one year later because of disseminated disease. In an attempt to obtain new insights into the physiopathology of this very rare tumor, an immunohistochemical panel with 32 markers was performed. The neoplastic cells were positive for cytokeratin 5, vimentin, p63... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=751435 Mon, 23 Jul 2007 04:00:00 +0100 751435 http://www.medworm.com/index.php?rid=735044&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F25 Conclusion: Our study is the first to describe the frequency of EBV-GC in Iran and the Middle East, highlighting a very low prevalence with specific clinicopathologic features. The predominance of EBV-GC birth year in a fixed period, suggests that EBV infection or other events at early childhood may be related to the development of EBV-GC later in the life. The predominance of the type "i" and XhoI+ cases are contradictory to other studies in Asia and is similar to what is reported from Latin American countries. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=735044 Sun, 15 Jul 2007 04:00:00 +0100 735044 http://www.medworm.com/index.php?rid=707582&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F23 Conclusions: Primary testicular angiosarcomas are typically rare tumors of men of all ages that appear to segregate into 2 groups; one associated with teratoma and occurring in young people, and the other occurring in the elderly and not associated with germ cell neoplasm, but may be associated with chronic hydrocele. They present with advanced disease and show a wide histologic spectrum. However, their prognosis may be better than previously thought. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=707582 Mon, 02 Jul 2007 02:51:42 +0100 707582 http://www.medworm.com/index.php?rid=699146&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F20 Folliculo-stellate cells are a nonendocrine, sustentacular-like complementary population of the anterior pituitary. They currently are considered as functionally and phenotypically heterogeneous, with one subpopulation of folliculo-stellate cells possibly representing resident adenohypophyseal macrophages. We took advantage of a limited T-cell mediated inflammatory reaction selectively involving tumor tissue in three cases of pituitary adenoma (2 prolactin cell adenomas, and 1 null cell adenoma) to test the hypothesis whether some folliculo-stellate cells within inflammatory foci would also assume monocytic/dendritic properties. Immunohistochemical double labeling for S-100 protein and the class II major histocompatibility antigen HLA-DR indeed showed several arborized cells to coexpress b... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=699146 Wed, 27 Jun 2007 04:00:00 +0100 699146 http://www.medworm.com/index.php?rid=681811&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F19 Conclusion: Ten cases of SFT of the thigh have been reported but to our knowledge this is the first case with epithelioid morphology affecting the extremities. Identification of this pattern of SFT is of importance, to avoid misdiagnosis with other more aggressive conditions in soft tissue. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=681811 Mon, 18 Jun 2007 04:00:00 +0100 681811 http://www.medworm.com/index.php?rid=672076&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F18 We report a case of cotyledonoid dissecting leiomyoma in a 52 year old woman who presented with menorrhagia and abdominal pain. An ultrasound scan showed a bulky uterus and a cystic heterogenous mass near the left ovary. At hysterectomy, the left broad ligament mass was removed. This was continuous with an ill-defined nodular area in the myometrial fundus. Microscopy revealed a benign smooth muscle proliferation in the myometrium that extended beyond the uterus and into the broad ligament. The lesion appeared to be dissecting the myometrial fibres and showed areas of oedema, hyalinisation and perinodular hydropic change. Cellular atypia, mitoses and coagulative necrosis were absent. The patient is alive and well 18 months after surgery. It is important to recognize this benign and unusual ... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=672076 Wed, 13 Jun 2007 04:00:00 +0100 672076 http://www.medworm.com/index.php?rid=672077&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F17 Conclusions: The literature data confirm that surgical resection is the treatment of choice in all cases of CCAM and in the cases of cystic pulmonary lesions with uncertain radiological findings, in order to perform a histological examination of the lesion and to prevent infection and the potential neoplastic transformation. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=672077 Thu, 07 Jun 2007 04:00:00 +0100 672077 http://www.medworm.com/index.php?rid=636569&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F16 Conclusion: The diagnosis of gastrointestinal parasites is not only made by examining the stool but the diagnosis can be made by histology from surgical specimens. Timely diagnosis and appropriate therapy might prevent probable future complications that may necessitate surgical procedures, at least in some of the patients. The clinical management of these infections is different from that for classical appendicitis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=636569 Thu, 24 May 2007 04:00:00 +0100 636569 http://www.medworm.com/index.php?rid=610420&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F15 Conclusions: Primary carcinoid tumor arising within mature teratoma of the kidney is a rare tumor that typically presents with abdominal pain without carcinoid syndrome. It is not associated with local recurrence and metastasis, is surgically curable, and has excellent prognosis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=610420 Thu, 17 May 2007 04:00:00 +0100 610420 http://www.medworm.com/index.php?rid=573279&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F12 Conclusion: The associated anomalies in Glomerulocystic Kidney disease are well described in the literature. Two more new unrelated associations are described in this article. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=573279 Wed, 25 Apr 2007 04:00:00 +0100 573279 http://www.medworm.com/index.php?rid=501965&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F11 We report the 16th case in a 39-year-old female. Her left kidney tumor was discovered incidentally. Partial nephrectomy was performed. Histologically, the tumor was composed of three components: 1) epithelial cysts lined by cuboidal to hobnail cells; 2) compact subepithelial mullerian-like AML stroma with admixed chronic inflammation; and 3) muscle-predominant AML with dysmorphic blood vessels exterior to the subepithelial stroma. Immunohistochemically, the subepithelial stroma stained most intensely with HMB-45 and Melan-A, whilst the muscle-predominant AML areas stained most intensely with smooth muscle actin and desmin. Estrogen receptor (ER), progesterone receptor (PR), and CD10 stained most intensely in the subepithelial stroma. The cyst lining was positive for pancytokeratin, but neg... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=501965 Wed, 21 Mar 2007 04:00:00 +0100 501965 http://www.medworm.com/index.php?rid=470262&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F10 Background: Almost all researchers agree on the lack of Bob-1 expression in Hodgkin/Reed-Sternberg (H/RS) cells in classic Hodgkin lymphoma (CHL), and utilize this marker as a diagnostic tool in conjunction with other markers to differentiate between lymphocyte predominance Hodgkin lymphoma (LPHL) and CHL. Aim: To study the immunohistochemical (IHC) expression of Bob-1 in Egyptian CHL and to correlate this expression with Epstein-Barr virus (EBV) viral load. Materials and Methods: Paraffin sections of randomly selected 18 CHL cases were included: 2 lymphocyte rich (LR), 4 mixed cellularity (MC), 10 nodular sclerosis (NS) and 2 lymphocyte depletion (LD). All cases were immunostained for Bob-1. EBV was evaluated by EBV early RNA transcripts in situ hybridization (EBER ISH) and immunostaining... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=470262 Thu, 08 Mar 2007 05:00:00 +0100 470262 http://www.medworm.com/index.php?rid=456436&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F8 Conclusion: The Yellow channel image analysis method based on a CMYK color model is independent of observer biases for threshold and positive color selection, applicable to different chromogens, tolerant of hematoxylin, sensitive to small changes in IHC intensity and is applicable to simple automation procedures. These characteristics are advantageous for both basic as well as clinical research in an unbiased, reproducible and high throughput evaluation of IHC intensity. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=456436 Tue, 27 Feb 2007 05:00:00 +0100 456436 http://www.medworm.com/index.php?rid=456437&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F7 This is the first case report of Histiocytic Sarcoma (HS) with predominant spindle cell component occurring in the head and neck region of a 41-year-old man. The tumor was composed of sheets of large round to oval cells with pleomorphic vesicular nuclei, prominent nucleoli and abundant eosinophilic cytoplasm. Multinucleated forms, numerous mitoses, and tumor necrosis were also noted. Sheets, fascicles, and whorls of spindle cells with spindled to ovoid vesicular nuclei, small to medium-sized distinct nucleoli, and eosinophilic cytoplasm were frequently observed. Immunohistochemical staining in the tumor cells was positive for CD163, CD68, lysozyme, CD45, and NSE. Focal expression of CD4 and S-100 was also noted. Electron microscopy demonstrated an abundance of lysosomes in the cytoplasm of... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=456437 Mon, 26 Feb 2007 05:00:00 +0100 456437 http://www.medworm.com/index.php?rid=415237&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F6 We report 33rd case, a 41-year-old male who presented with pain in the nape of neck. MRI showed a large, predominantly solid mass involving the cerebral parenchyma of left temporal and parieto-occipital lobes with extension across midline. Histologically, it was a mixture of glial and neuronal components. Architecturally, the tumor was notable for its pseudopapillary pattern with hyalinized vessels. PGNT is considered as a low grade neoplasm and surgical excision has been curative in most of the cases. Therefore every new case of PGNT needs to be reported to allow its recognition and classification. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=415237 Thu, 08 Feb 2007 07:00:00 +0100 415237 http://www.medworm.com/index.php?rid=404159&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F5 Conclusions: To our knowledge, this is the second case report describing coexistence of hepatocellular carcinoma and splenic marginal zone lymphoma in the course of chronic HBV infection. However, we cannot assert at present that hepatitis B virus is directly involved in splenic lymphomagenesis until more information is collected from more cases in the future. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=404159 Tue, 06 Feb 2007 07:00:00 +0100 404159 http://www.medworm.com/index.php?rid=389172&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F4 This study was conducted to evaluate the immunohistochemical (IHC) expression of interleukin 8 (IL-8) in skin biopsies of inflammatory acne vulgaris (IAV) in an attempt to understand the disease pathogenesis. Materials and Methods: a total of 58 biopsies, 29 from lesional IAV and 29 normal non lesional sites were immunostained for IL-8. The intensity of staining was evaluated in the epidermis and dermis and was scored as mild, moderate and severe. The expression was correlated with the clinical grade, disease course and histological changes. Results: IL-8 immunoreactivity was expressed in lesional IAV compared to non lesional skin biopsies (p (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=389172 Tue, 30 Jan 2007 07:00:00 +0100 389172 http://www.medworm.com/index.php?rid=379595&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F3 Conclusion: Histological features in papillary meningiomas are papillary pattern, typical and atypical mitosis, necrosis, pleomorphism and a pseudorosette relationship of neoplastic cells to blood vessels mimicking the appearance of metastatic adenocarcinoma, papillary ependymoma, astroblastoma and choroid plexus papilloma. Histopathological features with histochemistry and immunohistochemistry help in confirming the diagnosis. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379595 Fri, 19 Jan 2007 07:00:00 +0100 379595 http://www.medworm.com/index.php?rid=456438&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F3 Conclusion: Papillary meningiomas are rare but well recognized variants of meningioma. They need to be differentiated from other intracranial tumors with a papillary pattern. They are malignant, frequently show bone and parenchymatous invasion and have the potential for extracranial metastasis. Their timely recognition could prevent local and distant metastasis and the mortality or morbidity associated with it. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=456438 Fri, 19 Jan 2007 05:00:00 +0100 456438 http://www.medworm.com/index.php?rid=379597&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F2 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379597 Wed, 10 Jan 2007 07:00:00 +0100 379597 http://www.medworm.com/index.php?rid=456439&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F2 (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=456439 Wed, 10 Jan 2007 05:00:00 +0100 456439 http://www.medworm.com/index.php?rid=379599&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F2%2F1%2F1 Conclusion: Differential diagnosis can be difficult without immunohistochemistry. Therefore, a comprehensive morphological and immunohistochemical analysis is necessary, but markers of cell cycle (apart from the assessment of proliferation) do not help. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379599 Tue, 09 Jan 2007 07:00:00 +0100 379599 http://www.medworm.com/index.php?rid=379600&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F1%2F1%2F46 Conclusion: The possibility of an adult Wilms' tumor should be considered when a patient presents with pain in the flank and a renal mass. Rarity of the tumor favors documentation in literature. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379600 Tue, 05 Dec 2006 07:00:00 +0100 379600 http://www.medworm.com/index.php?rid=379602&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F1%2F1%2F44 Conclusion: Although isolated nasal involvement of sarcoidosis is rare, otorhinolaryngologists should consider this condition in a differential diagnosis for sinonasal complaints. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379602 Tue, 21 Nov 2006 07:00:00 +0100 379602 http://www.medworm.com/index.php?rid=379601&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F1%2F1%2F45 Conclusion: In the management of a blind painful eye, it is extremely important to rule out an intraocular malignancy particularly in those patients who have not been followed by an ophthalmologist. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379601 Tue, 21 Nov 2006 07:00:00 +0100 379601 http://www.medworm.com/index.php?rid=379603&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F1%2F1%2F43 Conclusion: Through the use of mathematical models it was quantitatively demonstrated that when no external force field is applied, the rate of entropy production of cancerous cells is always higher than that of healthy cells. However, when the external energy of square wave electric pulses is applied to tissues, the rate of entropy production of normal cells may exceed that of cancerous cells. Consequently, the application of external energy to the body can reverse the direction of the entropy current. The harmful effect brought about by the entropy flow from cancerous to healthy tissue can be blocked by the reversed direction of entropy current from the irradiated normal tissue around the tumor. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379603 Wed, 15 Nov 2006 07:00:00 +0100 379603 http://www.medworm.com/index.php?rid=379604&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F1%2F1%2F42 DiscussionIn principle, the MeduMobile realised an interdisciplinary case presentation using video conference and web page. The evaluation indicates a high acception of such complex case presentation with multidisciplinary settings. The use of the notebooks in mobile learning enables an interconnective training and promotes a complex learning. (Source: Diagnostic Pathology) Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379604 Thu, 09 Nov 2006 07:00:00 +0100 379604 http://www.medworm.com/index.php?rid=379605&cid=s_34063_32_f&fid=34063&url=http%3A%2F%2Fwww.diagnosticpathology.org%2Fcontent%2F1%2F1%2F41 Prognosticators evaluating survival in breast cancer vary in significance in respect to lymph node status. Studies have shown e.g. that HER2/neu immunohistochemistry or HER2/neu gene amplification analysis do perform well as prognosticators in lymph node positive (LN +) patients but are less valuable in lymph node negative (LN -) patients. We collected data from different studies and tried to evaluate the relative significance of different prognosticators in LN+/LN- patient groups. In LN+ patients HER2/neu and E-cadherin immunohistochemistry were the statistically most significant prognosticators followed by proliferation associated features (mitotic counts by SMI (standardised mitotic index) or MAI (mitotic activity index), or S-phase fraction). Bcl-2 immunohistochemistry was also signifi... Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=379605 Wed, 08 Nov 2006 07:00:00 +0100 379605