MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Digestive and Liver Disease' source. Wed, 08 Feb 2012 16:28:13 +0100 http://www.medworm.com/index.php?rid=5667906&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865812000060%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667906 Wed, 08 Feb 2012 21:06:35 +0100 5667906 http://www.medworm.com/index.php?rid=5667907&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811004993%2Fabstract%3Frss%3Dyes Shape shifting, transformations and metamorphoses are common and fascinating themes in mythology, literature and folklore of different times. Among numerous examples of shape shifting, as physicians it is apt to mention The Strange Case of Dr. Jekyll and Mr. Hyde, by Robert Louis Stevenson, where the good Dr. Jekyll metamorphoses into the evil Mr. Hyde. Dr. Jekyll and Mr. Hyde: same character, two bodies with different morphology and with different biological behaviours. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667907 Fri, 20 Jan 2012 05:00:00 +0100 5667907 http://www.medworm.com/index.php?rid=5583191&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811004786%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583191 Sat, 14 Jan 2012 06:28:25 +0100 5583191 http://www.medworm.com/index.php?rid=5583210&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003847%2Fabstract%3Frss%3Dyes The publisher regrets that an error appeared in the author listing of the original article. The corrected list appears above. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583210 Mon, 19 Dec 2011 05:00:00 +0100 5583210 http://www.medworm.com/index.php?rid=5667918&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811004221%2Fabstract%3Frss%3Dyes Abstract: Background: Hepatitis C virus infection is characterised by enhanced oxidative stress, which can be measured quantitatively by plasma oxysterol concentration. These molecules may affect lipid metabolism through the activation of Liver X Receptors. Hepatitis C virus exploits host lipid metabolism to facilitate its replication and diffusion. In our study we aimed to evaluate and highlight the potential pathogenetic role of oxysterols, 7-ketocholesterol and 7-β-hydroxycholesterol, in hepatitis C virus-related lipid dysmetabolism.Methods: The study was performed in 42 patients with chronic hepatitis C (93% genotype 1b) and 38 non-alcoholic fatty liver disease patients. Plasma oxysterols 7-ketocholesterol and 7-β-hydroxycholesterol were determined by isotope dilution gas chromatogra... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667918 Mon, 12 Dec 2011 05:00:00 +0100 5667918 http://www.medworm.com/index.php?rid=5583209&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100421X%2Fabstract%3Frss%3Dyes We thank Dr Filik for his comment. In fact, none of the children in our study have dermatitis herpetiformis nor required any dermatological examination. However, on the basis of the literature we expect a similar intestinal pattern in dermatitis herpetiformis. Whilst in the skin epithelial tissue transglutaminase (TG3) is the main target of the autoimmune response , and in serum antibodies react with greater avidity to TG3, in the gut of 7/11 dermatitis herpetiformis patients deposits of IgA antibodies were found , in this case the antigen being tissue transglutaminase (TG2). Therefore, the anti-transglutaminase response in the gut would not discriminate between coeliac disease and DH. It is clear that more observations are necessary. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583209 Wed, 07 Dec 2011 05:00:00 +0100 5583209 http://www.medworm.com/index.php?rid=5667924&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811004233%2Fabstract%3Frss%3Dyes We read with great interest the comments of Mion et al., who raised the question of transient relaxations of lower oesophagus sphincter (TLESRs) as a possible mechanism involved in rumination episodes . According to the authors, this is supported by the concomitant elevation of the LES, the common-cavity phenomena, and presence of gastric material in the oesophagus. So far, this possibility cannot be ruled out using current technology, although few points do not support such a hypothesis. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667924 Mon, 05 Dec 2011 05:00:00 +0100 5667924 http://www.medworm.com/index.php?rid=5667912&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003872%2Fabstract%3Frss%3Dyes Conclusion: Prevalence of functional gastrointestinal disorder symptoms was stable over time but the turnover in symptoms was high. A higher number of subjects had no symptoms in Iceland than in Olmsted County and there was a greater variation in subjects having different symptoms at follow up. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667912 Fri, 02 Dec 2011 05:00:00 +0100 5667912 http://www.medworm.com/index.php?rid=5525944&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100418X%2Fabstract%3Frss%3Dyes The use of endoscopically placed gastrointestinal stents has become a mainstay in the management of various types of benign and malignant strictures over the past several years. The benefits of palliative stent placement in patients with gastric outlet obstruction from advanced malignancies are less well established in comparison with oesophageal obstruction. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525944 Wed, 30 Nov 2011 05:00:00 +0100 5525944 http://www.medworm.com/index.php?rid=5667921&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003811%2Fabstract%3Frss%3Dyes Conclusion(s): This population-based study reports that only 55% of colorectal patients have a sufficient number of lymph nodes examined. This insufficient number of examined lymph nodes could be considered as a potential prospect for increasing treatment quality in cancer patients in France. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667921 Mon, 28 Nov 2011 05:00:00 +0100 5667921 http://www.medworm.com/index.php?rid=5667917&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811004129%2Fabstract%3Frss%3Dyes Conclusion: In cirrhotic rats with ascites: (a) pentoxifylline as well as norfloxacin reduced intestinal bacterial overgrowth and bacterial translocation and prevented spontaneous bacterial peritonitis; (b) pentoxifylline, but not norfloxacin, reduced oxidative stress in cecal mucosal. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667917 Mon, 28 Nov 2011 05:00:00 +0100 5667917 http://www.medworm.com/index.php?rid=5667914&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003859%2Fabstract%3Frss%3Dyes Conclusions: 2-L PEG+ascorbic acid, completed with an additional L of clear fluids, provided bowel cleansing which appeared to be more effective and acceptable than 4-L PEG. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667914 Mon, 28 Nov 2011 05:00:00 +0100 5667914 http://www.medworm.com/index.php?rid=5667913&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811004105%2Fabstract%3Frss%3Dyes Conclusions: Absence of weight loss, dysphagia, and gastrointestinal bleeding predicts low likelihood of malignancy in dyspeptic Taiwanese patients aged (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667913 Thu, 24 Nov 2011 05:00:00 +0100 5667913 http://www.medworm.com/index.php?rid=5667909&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003884%2Fabstract%3Frss%3Dyes Abstract: Colorectal cancer is still the third most common cancer in the world. Its carcinogenesis has been extensively studied at a molecular point of view, and has recently entered the era of microRNAs, a class small non-coding RNAs that post-transcriptionally regulate gene expression and control various cellular mechanisms. Because they control biological processes that are implicated in carcinogenesis (as developmental transitions, organ morphology, apoptosis and cell proliferation), microRNAs have been linked to cancer development, and these molecules have been recently studied as new potential biomarkers to better characterise tumour prognosis and to predict response to the different active chemotherapy.This review summarizes the potential roles of microRNAs as potential biomarkers f... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667909 Mon, 21 Nov 2011 05:00:00 +0100 5667909 http://www.medworm.com/index.php?rid=5525962&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811004294%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525962 Mon, 21 Nov 2011 05:00:00 +0100 5525962 http://www.medworm.com/index.php?rid=5667910&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003835%2Fabstract%3Frss%3Dyes Conclusions: SLCO1B1*1b haplotype may identify patients at increased risk for aspirin-induced peptic ulcer. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667910 Wed, 16 Nov 2011 05:00:00 +0100 5667910 http://www.medworm.com/index.php?rid=5667915&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003732%2Fabstract%3Frss%3Dyes Conclusions: EUS and MRI are complementary and should be performed at initial evaluation in multiple endocrine neoplasia type 1 patients. Whether follow-up should be based on either technique or both, requires further evaluation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667915 Mon, 14 Nov 2011 05:00:00 +0100 5667915 http://www.medworm.com/index.php?rid=5667911&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003823%2Fabstract%3Frss%3Dyes Conclusions: Half of the ulcerative colitis patients responding to a first course of corticosteroids will require immunosuppressors mainly because of steroid-dependence. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667911 Mon, 14 Nov 2011 05:00:00 +0100 5667911 http://www.medworm.com/index.php?rid=5388460&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003926%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388460 Thu, 10 Nov 2011 10:37:23 +0100 5388460 http://www.medworm.com/index.php?rid=5667908&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003756%2Fabstract%3Frss%3Dyes Conclusions: A diet high in protein, particular animal protein, may be associated with increased risk of inflammatory bowel disease and relapses. N-6 polyunsaturated fatty acids may predispose to ulcerative colitis whilst n-3 polyunsaturated fatty acid may protect. These results should be confirmed in other countries and in younger subjects before dietary counselling is recommended in high risk subjects. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667908 Fri, 04 Nov 2011 04:00:00 +0100 5667908 http://www.medworm.com/index.php?rid=5667923&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003720%2Fabstract%3Frss%3Dyes We read with interest the short report of Gourcerol et al. on the physiopathology of the rumination syndrome. Using concomitant high resolution oesophageal manometry, intra-luminal impedance and video-fluoroscopy, they give rather convincing evidence of intra-thoracic displacement of the lower oesophageal sphincter (LES) during rumination episodes. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667923 Thu, 03 Nov 2011 04:00:00 +0100 5667923 http://www.medworm.com/index.php?rid=5583196&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003744%2Fabstract%3Frss%3Dyes Conclusions: The use of methotrexate appears to be negligible in clinical practice. However, our results suggest that, if appropriately used, methotrexate could be more widely administered to inflammatory bowel disease patients with complicated disease. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583196 Thu, 03 Nov 2011 04:00:00 +0100 5583196 http://www.medworm.com/index.php?rid=5667926&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003719%2Fabstract%3Frss%3Dyes Splenic haemangioma (SH) is a rare benign disorder, although spontaneous rupture with massive haemorrhage can occur in these patients . Traditional treatment most often consists of splenectomy. Radiofrequency ablation (RFA) is a thermal treatment technique which has been successfully used for the treatment of hepatic haemangioma; however, it has not been reported for treatment of SH. A 43-year-old man presented to our department with a 2-month history of left upper quadrant pain. All laboratory data were within normal limits except for thrombocytopenia (PLT 72×109/L). Magnetic resonance imaging showed a single tumour with a diameter of 2.3cm in the spleen (Fig. 1), Preoperative evaluation led to the diagnosis of SH. The patient underwent laparoscopy through insertion of 2 trocars, which d... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667926 Wed, 02 Nov 2011 04:00:00 +0100 5667926 http://www.medworm.com/index.php?rid=5667925&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003707%2Fabstract%3Frss%3Dyes A 57-year-old man with diabetes mellitus and alcohol-related liver disease presented with a 2-day history of nausea, vomiting and reduced appetite. On examination, he was apyrexial with right upper quadrant tenderness. Laboratory tests revealed microcytic anaemia (haemoglobin 8.9g/dL, MCV 79fL), and elevated white blood cell count (15.8×109/L), C-reactive protein (248mg/L), alkaline phosphatase (416IU/L) and gamma-glutamyltransferase (151IU/L). Blood cultures were sterile. Abdominal ultrasound scan (Fig. 1A) showed multiple, large, mixed echoic lesions (the largest 11cm in diameter), predominantly within the right lobe of the liver. Hepatic metastases were considered, but staging CT scan (Fig. 1B) did not detect a primary neoplasm and tumour markers were within normal limits. CT-guided dr... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667925 Wed, 26 Oct 2011 04:00:00 +0100 5667925 http://www.medworm.com/index.php?rid=5667920&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003690%2Fabstract%3Frss%3Dyes Conclusion: Amongst patients with BD-IPMNs, about 10% have surgery within approximately 1 year from the time of diagnosis because of the occurrence of new malignant stigmata. Therefore, a conservative approach without surgery and careful follow-up every 3 months or 6 months during the first year after diagnosis can be safely advocated in patients with BD-IPMNs larger than 10mm in size who have no risk factors for malignant IPMNs. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667920 Wed, 26 Oct 2011 04:00:00 +0100 5667920 http://www.medworm.com/index.php?rid=5583195&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003665%2Fabstract%3Frss%3Dyes Conclusion: Laparoscopic restorative proctocolectomy can be performed safely without a diverting stoma in selected patients. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583195 Mon, 24 Oct 2011 04:00:00 +0100 5583195 http://www.medworm.com/index.php?rid=5583193&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003677%2Fabstract%3Frss%3Dyes Abstract: The available data concerning recently marketed computer simulators for training in digestive endoscopy suggest that they could play a role in the pre-clinical phase of training, thus potentially leading to a shorter learning curve and better performance in the endoscopy room during the early phase of hands-on training. Technical improvements are still needed before such simulators can be used for the retraining of experienced endoscopists and for training in the use of newly developed devices dedicated to therapeutic endoscopy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583193 Mon, 24 Oct 2011 04:00:00 +0100 5583193 http://www.medworm.com/index.php?rid=5525946&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003422%2Fabstract%3Frss%3Dyes Conclusion: We demonstrate that the neuropeptides CGRP and SP exert opposing effects in oxazolone colitis and provide further evidence for a prominent neuroimmune association in the gut. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525946 Mon, 24 Oct 2011 04:00:00 +0100 5525946 http://www.medworm.com/index.php?rid=5388461&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003410%2Fabstract%3Frss%3Dyes In the era of biologics, the proportion of patients with Crohn's disease (CD) not entering remission remains high. Hence, new therapeutic approaches are eagerly awaited. Haematopoietic stem cell transplantation (HSCT) is a standard treatment for many haematological diseases. The rationale of using HSCT in autoimmune diseases is to achieve the complete ablation of the aberrant immune system and to regenerate a new and antigen-naive immune system. HSCT can induce sustained remission in refractory multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, juvenile arthritis, and haematologic immune cytopenia . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388461 Mon, 17 Oct 2011 04:00:00 +0100 5388461 http://www.medworm.com/index.php?rid=5583204&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003641%2Fabstract%3Frss%3Dyes Conclusions: These results suggested a differential impact of geographical variables on the detection rates of colorectal adenomas and cancers in the population. Further studies are needed to examine socio-economic factors likely to be involved in these disparities. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583204 Fri, 14 Oct 2011 04:00:00 +0100 5583204 http://www.medworm.com/index.php?rid=5525960&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100363X%2Fabstract%3Frss%3Dyes The Publisher regrets that an error appeared in the name of one of the authors in the original article. The corrected full list of authors appears above. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525960 Fri, 14 Oct 2011 04:00:00 +0100 5525960 http://www.medworm.com/index.php?rid=5667916&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003653%2Fabstract%3Frss%3Dyes Abstract: Background: Increasing evidence shows that Hepatitis B virus infection associates with B-cell but not T-cell malignancies. It remains unclear (a) whether this association is restricted to discrete subtypes of B-cell neoplasms and (b) if occult hepatitis B virus infection can impact on the risk of B-cell malignancy.Methods: We analysed the prevalence of occult hepatitis B virus infection in three age and sex matched groups: patients with multiple myeloma, chronic lymphocytic leukaemia and healthy volunteers (N=80 each group). Hepatitis B virus sequences were detected by PCR in blood mononuclear cells isolated prior to treatment.Results: Fifteen subjects tested positive for occult hepatitis B virus infection and its distribution significantly favoured chronic lymphocytic leukaemia ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667916 Thu, 13 Oct 2011 04:00:00 +0100 5667916 http://www.medworm.com/index.php?rid=5583192&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003318%2Fabstract%3Frss%3Dyes Abstract: Malignant well-differentiated neuroendocrine tumours of the pancreas and the gastrointestinal tract are rare and clinically challenging heterogeneous neoplasms. This review focuses on neuroendocrine tumours grade 1 and grade 2 (new WHO classification 2010), in comparison to the neuroendocrine tumours grade 3 group, corresponding to poorly differentiated neuroendocrine carcinomas. Surgical resection of the primary and metastases remains the only curative treatment, however many patients with neuroendocrine tumours are diagnosed once unresectable metastases have occurred; management of functioning syndromes with somatostatin analogues remains the priority. Pasireotide, a new somatostatin analogue, is currently undergoing evaluation for carcinoid syndrome. Treatment options for adva... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583192 Mon, 10 Oct 2011 04:00:00 +0100 5583192 http://www.medworm.com/index.php?rid=5583208&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003628%2Fabstract%3Frss%3Dyes I read with great interest the recent article by Maglio et al. . The article has very important data regarding the diagnostic value of anti-tissue transglutaminase IgA in childhood coeliac disease. However, I found there is an issue to be discussed further. The item of my concern is related to dermatitis herpetiformis. Dermatitis herpetiformis and coeliac disease are two closely related gluten-sensitive disorders, and coeliac disease patients may also have dermatitis herpetiformis. However, dermatitis herpetiformis is seldom diagnosed in childhood, unlike coeliac disease, and generally manifests in early or middle adult life. Serum antibodies against TG2 can be sensitive and specific for dermatitis herpetiformis as well as coeliac disease . Transglutaminase 3 (TG3) is the dominant autoanti... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583208 Wed, 05 Oct 2011 04:00:00 +0100 5583208 http://www.medworm.com/index.php?rid=5583205&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003392%2Fabstract%3Frss%3Dyes A 70-year-old male presented with generalised abdominal pain and fever of 7 days’ duration. Medical history included arterial hypertension and stable angina pectoris. The physical examination showed localized signs of peritonitis in the left lower quadrant; blood tests revealed leukocytosis (12.4×103/μL) and elevated C-reactive protein (26.7mg/dL). Abdominal computed tomography showed multiple diverticula in the distal ileum with circumferential thickening of the wall, dishomogeneity of mesenteric fat and perivisceral extraluminal air (Fig. 1); diverticula were present throughout the colon. Perforated diverticulits of the terminal ileum was diagnosed. Piperacillin/tazobactam therapy was started and explorative laparotomy was scheduled. Surgical exploration, through a minilaparotomy, co... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583205 Wed, 05 Oct 2011 04:00:00 +0100 5583205 http://www.medworm.com/index.php?rid=5583203&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003409%2Fabstract%3Frss%3Dyes Conclusions: ACLF has very high mortality. Hepatic encephalopathy, low serum sodium and high INR predict poor outcome. Mortality can also be predicted by baseline MELD, SOFA or APACHE-II scores. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583203 Wed, 05 Oct 2011 04:00:00 +0100 5583203 http://www.medworm.com/index.php?rid=5583202&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003367%2Fabstract%3Frss%3Dyes Abstract: Background: The association between hepatitis C infection and lymphoid malignancies is still a matter of debate. The hypothesis of a relationship between hepatitis B and lymphoid neoplasms is more recent and has been far less thoroughly explored.Aim: The aim of this study was to evaluate the association between hepatitis C and B infections and B cell non-Hodgkin and Hodgkin lymphomas.Methods: We took advantage of the co-existence in the French administrative area of Côte d’Or of two specialized registries – one for viral hepatitis and one for haematological diseases – to conduct a population-based, cohort study covering a 12-year period. The databases were anonymized and then linked using a probabilistic model.Results: There were 8234 person-years at risk in the hepatitis ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583202 Wed, 05 Oct 2011 04:00:00 +0100 5583202 http://www.medworm.com/index.php?rid=5525947&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003434%2Fabstract%3Frss%3Dyes Conclusions: TNF-like cytokine 1A and Decoy receptor-3 are upregulated during active Crohn's disease and may participate in disease pathogenesis and offer novel therapeutic opportunities. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525947 Wed, 05 Oct 2011 04:00:00 +0100 5525947 http://www.medworm.com/index.php?rid=5388462&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003689%2Fabstract%3Frss%3Dyes Capsule endoscopy is an effective tool for the evaluation of small bowel diseases, with a higher diagnostic yield when compared to other small bowel imaging modalities. Virtual chromoendoscopy, i.e., Narrow Band Imaging (NBI – Olympus, Tokyo, Japan), Fuji Intelligent Colour Enhancement (FICE, Fujinon Inc., Saitama, Japan) and I-Scan (Pentax, Tokyo, Japan), is a well established technology that in combination with magnification and high resolution image enables inspection of microvascular patterns and circumvents some limitations of conventional chromoendoscopy. The main advantage of virtual chromoendoscopy is the convenience of a quick push-button switching between white light and chromoendoscopy modes, without the need for dye spraying. Moreover, dye spraying would be unfeasible during ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388462 Wed, 05 Oct 2011 04:00:00 +0100 5388462 http://www.medworm.com/index.php?rid=5583212&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003380%2Fabstract%3Frss%3Dyes A 59-year-old woman presented to our hospital after 2 days of progressive abdominal pain, nausea and vomiting. The physical examination showed a distended abdomen, hypoactive bowel sounds, and diffuse abdominal tenderness. The laboratory tests revealed white-cell count of 6450 per cubic millimetre with 78% neutrophils. A contrast enhanced computed tomographic scan of the abdomen revealed lipomatosis of small bowel and causing bowel obstruction (Fig. 1). An explorative laparotomy discovered lipomatosis of small intestine and mesentery (Fig. 2A), which were causing intestinal obstruction. Segmental resection of tumour-involved intestine was performed. The pathological diagnosis was confirmed with lipomatous polyposis of ileum. Under microscopy sections, the specimen showed small intestinal t... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583212 Tue, 04 Oct 2011 04:00:00 +0100 5583212 http://www.medworm.com/index.php?rid=5667922&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003355%2Fabstract%3Frss%3Dyes A 78-year-old woman presented with anaemia and a positive faecal occult blood test. Routine work-up disclosed no abnormalities except for reduced haemoglobin levels (8.6g/dl). Total colonoscopy revealed a type 1-like tumour in the cecum (A), and friable epithelium was seen after indigo carmine dye (B). Subsequently, she underwent a laparoscopic ileocecal resection with a regional lymphadenectomy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667922 Mon, 03 Oct 2011 04:00:00 +0100 5667922 http://www.medworm.com/index.php?rid=5583207&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003343%2Fabstract%3Frss%3Dyes The debate over digestive oncology (DO) is flaring up again, as demonstrated by Prof. Rougier's Editorial in a recent issue of Digestive and Liver Disease (DLD) ; Prof. Crespi and myself reported this over ten years ago stressing that the gastroenterologist's absence from the field of DO was evident even at the undergraduate level, as only epidemiology, pathogenesis and diagnosis of gastrointestinal (GI) cancers were being taught. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583207 Mon, 03 Oct 2011 04:00:00 +0100 5583207 http://www.medworm.com/index.php?rid=5525961&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003008%2Fabstract%3Frss%3Dyes Purpose: To illustrate the spectrum of abnormalities in abdominal imaging studies, their correlation with clinical findings, and differential diagnosis. Content: This is the first edition of this text; it comprehensively describes disorders affecting the gastro-intestinal tract, both in adults and children. Each topic is organized in sections including anatomical findings, clinical presentation, epidemiology, imaging, and differential diagnosis, and a short summary entitled “what the referring physician needs to know”. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525961 Fri, 30 Sep 2011 04:00:00 +0100 5525961 http://www.medworm.com/index.php?rid=5583201&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003306%2Fabstract%3Frss%3Dyes Conclusions: Hepatic and splenic arteries resistance indexes and the hepatic veins waveform pattern assessed by Doppler ultrasound may provide information similar to that of Transient Elastography in hepatitis C related chronic liver disease. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583201 Wed, 28 Sep 2011 04:00:00 +0100 5583201 http://www.medworm.com/index.php?rid=5525945&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003082%2Fabstract%3Frss%3Dyes Conclusion: These data demonstrate increased IL-8 production by foetal myofibroblasts that is partially mediated by Toll-like receptor 4, mitogen activated protein kinase and NF-κB cell signalling pathways. Intestinal myofibroblasts cells may contribute to the dysregulated inflammatory response in the immature intestine and may form targets that lead to new therapies to prevent neonatal intestinal inflammatory bowel diseases. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525945 Wed, 28 Sep 2011 04:00:00 +0100 5525945 http://www.medworm.com/index.php?rid=5583211&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003100%2Fabstract%3Frss%3Dyes A 79-year-old male, with type 2 diabetes mellitus and hypertension, presented with dull aching epigastric pain, weight loss of 6kg, and weakness of lower limbs for 40 days. Physical examination revealed myelopathy at T10 level. Laboratory findings were: γ-GT: 287U/L, AST: 62IU/L, CA19-9: 40U/ml, and αFP: 9797ng/ml. A 2cm hypodense tumour at the pancreatic head with celiac lymph node and liver metastases were noted on computed tomography. Endoscopic ultrasound (EUS) demonstrated vascular signals (a), hypoechoic rim, and hyperechoic strands with heterogeneous echo pattern (b). T-spine metastasis was documented with magnetic resonance imaging. No liver cirrhosis was found. EUS-fine needle aspiration biopsy (FNAB) of the pancreatic mass, celiac lymph node, and liver lesions all demonstrated ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583211 Mon, 26 Sep 2011 04:00:00 +0100 5583211 http://www.medworm.com/index.php?rid=5583206&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003094%2Fabstract%3Frss%3Dyes At present, endoscopic resection of dysplasia in Barrett's oesophagus is a well-consolidated therapeutic approach . However, Barrett's epithelium with or without dysplasia may be missed on mucosectomy specimens, especially when buried islands are present . Thus, improving the yield of pathological results after mucosectomy is a major goal, especially concerning the resection margins . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583206 Mon, 26 Sep 2011 04:00:00 +0100 5583206 http://www.medworm.com/index.php?rid=5583194&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100329X%2Fabstract%3Frss%3Dyes Conclusions: Increased duration between symptoms and definitive diagnosis increases mortality risk. Early diagnosis and prompt initiation of anti-tuberculosis therapy improve prognosis. Neutrophil-predominant ascites influences poor prognosis when correlated with secondary bacterial peritonitis. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583194 Mon, 26 Sep 2011 04:00:00 +0100 5583194 http://www.medworm.com/index.php?rid=5388465&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002842%2Fabstract%3Frss%3Dyes Abstract: Introduction: Studies have reported that the association between overweight and erosive oesophagitis is very strong, whilst seeming less consistent with non-erosive reflux disease.Aim: We have hypothesized that this difference may be due to the heterogeneity of endoscopy-negative population.Methods: We studied 81 patients with erosive oesophagitis, 48 controls and 295 endoscopy-negative patients classified by impedance-pH-testing as: (1) pH-POS (abnormal acid exposure); (2) hypersensitive oesophagus (normal acid exposure/SAP+); (3) functional heartburn (normal acid exposure/SAP−). Body mass index was also calculated.Results: Mean body mass index was significantly higher (p (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388465 Fri, 23 Sep 2011 04:00:00 +0100 5388465 http://www.medworm.com/index.php?rid=5238845&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100346X%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238845 Thu, 22 Sep 2011 10:20:59 +0100 5238845 http://www.medworm.com/index.php?rid=5525948&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003033%2Fabstract%3Frss%3Dyes Conclusions: Safety and effectiveness of duodenal stenting for palliation of malignant gastroduodenal obstruction was confirmed in the largest international prospective series to date. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525948 Wed, 21 Sep 2011 04:00:00 +0100 5525948 http://www.medworm.com/index.php?rid=5667919&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003057%2Fabstract%3Frss%3Dyes Abstract: Background: Intraductal papillary neoplasms of the bile duct have been applied to certain types of papillary tumours occurring in the biliary tract. Although many cases have been sporadically reported, there remain controversies.Aims: To analyze the clinicopathologic characteristics and long-term survival of intraductal papillary neoplasms of the bile duct.Methods: The clinicopathologic data of 52 patients who underwent surgery for intraductal papillary neoplasms of the bile duct were retrospectively evaluated.Results: In our series, tumours located in intrahepatic and hilar bile duct, rather than in extrahepatic bile duct, were more commonly diagnosed as adenomas or borderline tumours (12/19 and 7/13 vs 6/20; P=0.046). And the gastric type was more commonly associated with adeno... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5667919 Mon, 19 Sep 2011 04:00:00 +0100 5667919 http://www.medworm.com/index.php?rid=5583200&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003045%2Fabstract%3Frss%3Dyes Conclusions: Chronic methotrexate treatment induces a progressive increase in liver stiffness corresponding to mild or moderate perisinusoidal fibrosis for values >9kPa. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583200 Mon, 19 Sep 2011 04:00:00 +0100 5583200 http://www.medworm.com/index.php?rid=5583199&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003021%2Fabstract%3Frss%3Dyes This study aimed to determine the factors affecting medical costs of patients with acute pancreatitis during hospitalization using a Japanese administrative database.Methods: A total of 7193 patients with acute pancreatitis were referred to 776 hospitals. We defined “patients with high medical costs” as patients whose medical costs exceeded the 90th percentile in medical costs during hospitalization and identified the independent factors for patients with high medical costs with and without controlling for length of stay.Results: Multiple logistic regression analysis demonstrated that necrosectomy was the most significant factor for medical costs of acute pancreatitis during hospitalization. The odds ratio of necrosectomy was 33.64 (95% confidence interval, 14.14–80.03; p (Source: Di... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583199 Mon, 19 Sep 2011 04:00:00 +0100 5583199 http://www.medworm.com/index.php?rid=5583197&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003069%2Fabstract%3Frss%3Dyes Abstract: Background: Various types of self-expandable metal stents have been introduced for the palliation of malignant biliary obstruction.Aims: To compare the outcomes of WallFlex™ and Wallstent™ uncovered biliary self-expandable metal stents (SEMSs) for the palliation of patients with malignant biliary obstruction.Methods: Between October 2008 and December 2009, all SEMSs placed for malignant biliary obstruction were WallFlex™: all patients palliated were included in the study. Before October 2008, all the SEMSs placed for malignant biliary obstruction were Wallstent™, and the patients palliated from July 2007 to September 2008 were the comparative group.Results: A total of 58 WallFlex™ and 54 Wallstent™ SEMSs were placed, and efficacious biliary decompression was achieved ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583197 Mon, 19 Sep 2011 04:00:00 +0100 5583197 http://www.medworm.com/index.php?rid=5525959&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003070%2Fabstract%3Frss%3Dyes Peginterferon plus ribavirin is the current standard of care for chronic hepatitis C, which determines sustained virological response (SVR) in 30–50% of patients. Protease inhibitors (namely boceprevir and telaprevir) are a further advancement that could increase SVR to approximately 60% . Boceprevir and telaprevir have already been approved by the Food and Drug Administration (FDA) and are about to be marketed in Europe (boceprevir is available in France where its cost per patient is around €22,000 according to the website http://viralmatters.blogspot.com). The globalization of pharmaceutical markets has much increased the international homogeneity of drug prices; hence, transferring the cost of innovative drugs from one country to another is likely to imply a reasonable approximation... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525959 Mon, 19 Sep 2011 04:00:00 +0100 5525959 http://www.medworm.com/index.php?rid=5525955&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002982%2Fabstract%3Frss%3Dyes Conclusions: Subjects attending colonoscopy reporting a positive first degree family history are at increased risk for pathologically significant lesions. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525955 Mon, 19 Sep 2011 04:00:00 +0100 5525955 http://www.medworm.com/index.php?rid=5525953&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100301X%2Fabstract%3Frss%3Dyes Conclusions: This study demonstrates that in patients transplanted for hepatitis C virus-related cirrhosis Vitamin D3 modulates T lymphocyte activation, and provides a rationale for the evaluation of this compound as an immunosuppressive agent in liver-transplanted patients. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525953 Mon, 19 Sep 2011 04:00:00 +0100 5525953 http://www.medworm.com/index.php?rid=5388468&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002994%2Fabstract%3Frss%3Dyes Conclusions: Endoscopic submucosal dissection using retroflexion manoeuvre is a more effective method for the curative resection of gastric tumours involving pyloric channel. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388468 Thu, 15 Sep 2011 04:00:00 +0100 5388468 http://www.medworm.com/index.php?rid=5388477&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002969%2Fabstract%3Frss%3Dyes Conclusion: Intrarterial infusion of Irinotecan is feasible in patients with hepatocellular carcinoma on cirrhosis at a recommended dose of 25mg/m2/day, with no major adverse drug-related events, but with some concerns about the insertion and management of the intra-arterial device. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388477 Wed, 14 Sep 2011 04:00:00 +0100 5388477 http://www.medworm.com/index.php?rid=5209922&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003136%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209922 Mon, 12 Sep 2011 23:18:27 +0100 5209922 http://www.medworm.com/index.php?rid=5525952&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002957%2Fabstract%3Frss%3Dyes Abstract: Background: Transient elastography is a well-established method for detecting cirrhosis.Aim: To improve the performance of transient elastography in detecting hepatitis B cirrhosis by alanine aminotransferase (ALT)-stratified cutoffs, bilirubin normalization and transient elastography-based algorithms.Methods: A total of 315 compensated patients were analysed following liver biopsies, transient elastography, ultrasonography and blood tests.Results: The area under the receiver operating characteristics (ROC) curve of transient elastography for predicting cirrhosis was 0.88 (95% confidence interval 0.84–0.92). The cutoffs to exclude and confirm cirrhosis were 10.4kPa and 17.3kPa in patients with ALT (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525952 Mon, 12 Sep 2011 04:00:00 +0100 5525952 http://www.medworm.com/index.php?rid=5525943&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002945%2Fabstract%3Frss%3Dyes Abstract: Hereditary pancreatitis is a rare cause of chronic pancreatitis. The prevalence was evaluated to 0.3/100000 in Western Countries. Genetic disorders are due to mutations of the PRSS1 gene on the long arm of the chromosome 7, encoding for the cationic trypsinogen. The inheritance pattern is autosomal dominant with an incomplete penetrance (80%). Since 1996, more than 30 mutations were found. The three more common mutations are R122H, N29I and A16V. First symptoms begin since childhood, mainly before 10 years old. Main symptoms are pancreatic pain and acute pancreatitis (>70%). CP morphological changes as pancreatic calcifications are diagnosed at a median age of 22–25 years. Exocrine and endocrine pancreatic insufficiency occurred in 34% and 26% at a median age of 29 and 38 years... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525943 Mon, 12 Sep 2011 04:00:00 +0100 5525943 http://www.medworm.com/index.php?rid=5388466&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100291X%2Fabstract%3Frss%3Dyes Conclusions: HSCT can induce and maintain clinical and endoscopic remission in refractory Crohn's disease, which is associated with immunomodulation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388466 Mon, 12 Sep 2011 04:00:00 +0100 5388466 http://www.medworm.com/index.php?rid=5238847&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811003379%2Fabstract%3Frss%3Dyes When referring to surveillance, one can easily quote the expression that “being approximately right most of the time is better than being precisely right occasionally”, as reported by John M. Cowden. We should add, however, that continuous efforts to improve approximation have to be made. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238847 Mon, 12 Sep 2011 04:00:00 +0100 5238847 http://www.medworm.com/index.php?rid=5525954&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002970%2Fabstract%3Frss%3Dyes Conclusion: Prospective selection of chemotherapy based on TS, DPD, ERCC-1 and UGT1A1 expression in elderly advanced colorectal cancer patients failed to confirm previous results. A more accurate validation of retrospective findings is warranted before these molecular markers can be used for treatment selection in the clinical practice. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525954 Wed, 07 Sep 2011 04:00:00 +0100 5525954 http://www.medworm.com/index.php?rid=5388478&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002933%2Fabstract%3Frss%3Dyes Abstract: Background: Both upper and lower endoscopies are indicated in patients with iron deficiency anaemia. However, these examinations are negative in a high proportion of cases.Aims: To assess whether faecal-immunochemical test (FIT) may be useful in selecting patients at higher risk of bleeding lesions in iron deficiency anaemia patients.Methods: Iron deficiency anaemia patients without overt bleeding were prospectively enrolled. All patients performed FIT, and underwent both upper and lower endoscopy. Predictive factors of potential bleeding lesions were evaluated at multivariate analysis.Results: FIT was positive in 48 (34.3%) out of 140 enrolled patients, and a potential bleeding lesion was present in 63 (45%) patients. An endoscopic lesion was detected more frequently in FIT-posi... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388478 Wed, 07 Sep 2011 04:00:00 +0100 5388478 http://www.medworm.com/index.php?rid=5388470&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002830%2Fabstract%3Frss%3Dyes Conclusion: The occurrence of acinar cell carcinomas outside the pancreas underlines the notion that acinar cell carcinomas may originate in extrapancreatic sites and probably develop from heterotopic or metaplastic pancreatic foci present along the biliary tract. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388470 Wed, 07 Sep 2011 04:00:00 +0100 5388470 http://www.medworm.com/index.php?rid=5388467&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100288X%2Fabstract%3Frss%3Dyes Conclusion: Comparing with FICE, Blue filter offers better image enhancement in capsule endoscopy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388467 Wed, 07 Sep 2011 04:00:00 +0100 5388467 http://www.medworm.com/index.php?rid=5238846&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002921%2Fabstract%3Frss%3Dyes Liver fibrosis is the accumulation of newly synthesized extracellular matrix molecules within the liver, progressively culminating in cirrhosis, i.e. the formation of architectural abnormal nodules separated by fibrous tissue. All chronic inflammatory liver diseases, unless efficiently treated, lead sequentially to fibrosis and cirrhosis. Cirrhosis is not only fibrosis, i.e., the result of recurrent cycles of inflammation and repair due to persistence of the initiating injury, but also a process characterised by waves of parenchymal extinction due to bystander injury and thrombosis of the small hepatic and portal veins . Liver biopsy is traditionally the reference standard for grading liver fibrosis and to diagnose asymptomatic compensated cirrhosis. Because of its well-known limitation (s... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238846 Wed, 07 Sep 2011 04:00:00 +0100 5238846 http://www.medworm.com/index.php?rid=5525951&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002891%2Fabstract%3Frss%3Dyes Conclusion: In a HVPG-guided strategy, adding banding ligation to drugs is an effective rescue strategy to prevent rebleeding in haemodynamic non-responders to drug therapy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525951 Mon, 05 Sep 2011 04:00:00 +0100 5525951 http://www.medworm.com/index.php?rid=5525949&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002908%2Fabstract%3Frss%3Dyes Conclusions: Our findings suggest that the lipid levels in primary sclerosing cholangitis are often above levels where treatment with lipid-lowering agents is recommended. However, primary sclerosing cholangitis patients seem to have no elevated risk for cardiovascular events. The correlation of total and low-density lipoprotein cholesterol with liver biochemistries implies that mechanisms linked to cholestasis may regulate cholesterol metabolism. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525949 Mon, 05 Sep 2011 04:00:00 +0100 5525949 http://www.medworm.com/index.php?rid=5525950&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002866%2Fabstract%3Frss%3Dyes Conclusion: Rituximab-based chemotherapy favours an increase in HCV RNA in onco-haematological patients; this is followed by a hepatic flare, possibly immune-mediated and life threatening in cirrhotic patients. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525950 Thu, 01 Sep 2011 04:00:00 +0100 5525950 http://www.medworm.com/index.php?rid=5388474&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002878%2Fabstract%3Frss%3Dyes Conclusion: Autochthonous HEV infection is present in Southern Italy where it may cause AH. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388474 Wed, 31 Aug 2011 04:00:00 +0100 5388474 http://www.medworm.com/index.php?rid=5238851&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002829%2Fabstract%3Frss%3Dyes Abstract: Objective: Coeliac disease is associated with an increased risk of malignant lymphomas. We investigated the importance of coeliac disease characteristics and diet compliance for risk of lymphoma.Methods: In a nested case–control design, we identified 59 patients with lymphoma and 137 matched controls from a population-based cohort of 11,650 inpatients with coeliac disease. We assessed coeliac disease characteristics at diagnosis and dietary compliance collected prospectively from medical records during follow-up.Results: Poor compliance was not significantly associated with risk of lymphoma overall (odds ratio 1.83, 95% confidence interval 0.78–4.31) nor of lymphoma subtypes. Risk estimates differed by subtype; risk of T-cell lymphoma (odds ratio 1.01, confidence interval 0.3... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238851 Wed, 31 Aug 2011 04:00:00 +0100 5238851 http://www.medworm.com/index.php?rid=5388473&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002854%2Fabstract%3Frss%3Dyes Conclusions: Early, elective repair of umbilical hernias in cirrhotic patients should be advocated considering the hepatic reserve and patient's condition. Ascites control is the mainstay of post-operative management. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388473 Mon, 29 Aug 2011 04:00:00 +0100 5388473 http://www.medworm.com/index.php?rid=5238863&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100260X%2Fabstract%3Frss%3Dyes We appreciated the comments of Dr. Avolio et al. concerning our paper and are pleased to offer the following reply. The aim of our paper was to provide a methodological overview of the Liver Match project together with a detailed description of the donor and recipient populations included in the database, with particular attention to the potential donor risk factors, the type and severity of recipient disease and their current matching. These data had not been properly described in relation to the current Italian setting and are not necessarily similar to those observed in previous years. The present “descriptive” study was therefore not intended to present outcome data, which will be the objective of forthcoming reports, upon completion of the appropriate follow-up. We thought, howev... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238863 Mon, 22 Aug 2011 04:00:00 +0100 5238863 http://www.medworm.com/index.php?rid=5525958&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002817%2Fabstract%3Frss%3Dyes In this study, authors employed, both in Doppler endoscopic ultrasound and Dopper transabdominal ultrasound, measurement of Peak Systolic Velocity (PSV) in celiac artery and superior mesenteric artery as single parameter for the detection of chronic mesenteric ischaemia. We would add that, beside PSV, another Doppler parameter could be considered: End-Diastolic Velocity (EDV) appears comparable or superior to PSV in identify significant arteriography-detected stenosis, and is not influenced by an hyperdynamic circulation as for PSV . In the study of Almansa et al., Doppler endoscopic ultrasound (assessed by means of PSV) presented a specificity of 84% in detecting chronic mesenteric ischaemia; this figure could be even more appealing employing EDV. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525958 Fri, 19 Aug 2011 04:00:00 +0100 5525958 http://www.medworm.com/index.php?rid=5525957&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002568%2Fabstract%3Frss%3Dyes A 72-year old woman underwent a video-laparo duodeno-jejunal resection with a gastro-jejunal anastomosis for adenocarcinoma of the fourth duodenal portion. Because of hyperpyrexia and fluid material in abdominal drainages, the patient underwent abdominal Computed Tomography that revealed a 4cm×5cm peri-anastomotic fluid collection. An esophagogastroduodenoscopy (EGD) showed a leak of 1cm in diameter, promptly treated by endoscopic positioning of a 10mm traumatic over-the-scope clip (OTSC) following unsuccessful positioning of endoclips (reusable Olympus EZ Clip system). A naso-jejunal tube was additionally placed and i.v. antibiotic therapy was administered. After 7 days, a second endoscopy revealed the persistence of the anastomotic leak with the OTSC partially detached. Failure of OTSC ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525957 Fri, 19 Aug 2011 04:00:00 +0100 5525957 http://www.medworm.com/index.php?rid=5388469&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002805%2Fabstract%3Frss%3Dyes Conclusions: Patients with biliary neuroendocrine tumour showed extremely different clinical outcomes according to histopathologic subtypes by World Health Organization 2010 classification. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388469 Fri, 19 Aug 2011 04:00:00 +0100 5388469 http://www.medworm.com/index.php?rid=5209943&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001575%2Fabstract%3Frss%3Dyes A 78-year-old male peasant experienced intermittent melena for 2 years. Routine blood tests from a local hospital showed a haemoglobin (Hb) level of 7.5g/dL, indicating severe anaemia. Neither upper gastrointestinal (GI) endoscopy nor colonoscopy identified bleeding points. He subsequently underwent double-balloon enteroscopy in our department, which was negative. On admission, his vital signs were stable and physical examination showed no abnormalities except pale conjunctivae. Faecal occult blood test was positive and complete blood count showed Hb 7.0g/dL, mean corpuscular volume 64.7fL (88.3–98.0fL). Serum electrolytes, liver and renal function tests were all in normal ranges, tumour markers were negative. The patient was from a geographical area known for hookworm epidemics; as the ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209943 Thu, 18 Aug 2011 04:00:00 +0100 5209943 http://www.medworm.com/index.php?rid=5388472&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002611%2Fabstract%3Frss%3Dyes Conclusions: Omega-3 treatment significantly reduces experimental hepatic steatosis and associated pathophysiological features, resulting in significantly reduced IR injury following PHx. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388472 Tue, 16 Aug 2011 04:00:00 +0100 5388472 http://www.medworm.com/index.php?rid=5209923&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100257X%2Fabstract%3Frss%3Dyes Gastro-oesophageal reflux disease (GORD) is highly prevalent in western countries. The main clinical manifestations are represented by heartburn and regurgitation and they are commonly used for the diagnosis of GORD, although their accuracy is far from optimal . The above symptoms can occur during the daytime and also throughout the nocturnal period. In the past, the progressively widespread use of 24-h oesophageal pH-metry showed that the majority of reflux events belong to the post-prandial periods, whilst they are much less frequent during the night time . This temporal distribution of abnormal reflux episodes provided the rationale to explain, at least in part, the benefit of proton pump inhibitors (PPIs) in patients with GORD. In fact, these drugs are more effective during the daytime... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209923 Thu, 11 Aug 2011 04:00:00 +0100 5209923 http://www.medworm.com/index.php?rid=5388476&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002593%2Fabstract%3Frss%3Dyes Conclusion: Our data provide novel mutual relationships amongst cyclin E1–E2–E2F1 and indicate their role in sustaining hepatocellular carcinoma cell proliferation/migration, validating the concept of an anti-cyclin E1–E2–E2F1 therapeutic approach for hepatocellular carcinoma. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388476 Wed, 10 Aug 2011 04:00:00 +0100 5388476 http://www.medworm.com/index.php?rid=5388471&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002544%2Fabstract%3Frss%3Dyes Conclusion: Genetic barrier and reverse transcriptase/HBV surface antigen overlapping can synergistically influence hepatitis B virus drug-resistance/immune-escape development. The different immune-escape potential of specific hepatitis B virus genotypes could have important clinical consequences in terms of disease progression, vaccine strategies and correct HBV surface antigen detection. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388471 Wed, 10 Aug 2011 04:00:00 +0100 5388471 http://www.medworm.com/index.php?rid=5238859&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002532%2Fabstract%3Frss%3Dyes Conclusion: The FOLFIRI regimen, as first-line chemotherapy, achieved stabilisation in most patients whose tumours had been progressing and was well-tolerated. It could be an alternative therapy for advanced well-differentiated endocrine carcinomas of the pancreas. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238859 Wed, 10 Aug 2011 04:00:00 +0100 5238859 http://www.medworm.com/index.php?rid=5238857&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002118%2Fabstract%3Frss%3Dyes Abstract: Background/Aims: Colonoscopy has been proven a valuable tool in preventing colorectal cancer in controlled studies; we conducted a longitudinal confirmation study in everyday clinical practice.Methods: In a retrospective study, we monitored the outcome of patients with a total colonoscopy at our hospital between 1994 and 2007. We analysed the data of in-house follow-up colonoscopies, a national person registry and the morphological tumour registry centralizing all histopathological data at a national level. Patients with a particular colorectal cancer risk were excluded.Results: 8950 patients were included in our study. 2032 (22.7%) patients had at least one colorectal adenoma at index colonoscopy. Adenoma prevalence was significantly higher in men than in women (27.9% vs. 17.4%,... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238857 Wed, 10 Aug 2011 04:00:00 +0100 5238857 http://www.medworm.com/index.php?rid=5238850&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002581%2Fabstract%3Frss%3Dyes Conclusions: Our data suggest that FCGR2A, JAK2 or HNF4A variants play a role in the pathogenesis of ulcerative colitis in Koreans. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238850 Wed, 10 Aug 2011 04:00:00 +0100 5238850 http://www.medworm.com/index.php?rid=5388480&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001708%2Fabstract%3Frss%3Dyes We read with interest the review article by Huang et al. discussing on the role of the endocannabinoid (EC) system in liver diseases. Particularly, this review summarizes the recent insights gained into the pathophysiological processes associated with both acute and chronic liver diseases as well as the complications of end stage liver disease, including liver cancer. However, in this stimulating review cholangiopathies were not discussed. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388480 Thu, 04 Aug 2011 04:00:00 +0100 5388480 http://www.medworm.com/index.php?rid=5080610&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002647%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080610 Mon, 01 Aug 2011 16:28:21 +0100 5080610 http://www.medworm.com/index.php?rid=5238858&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002301%2Fabstract%3Frss%3Dyes Conclusions: The results of this study suggest that lipiodol transarterial chemoembolisation with anthracycline and amiodarone was safe but did not increase survival compared with lipiodol transarterial chemoembolisation with anthracycline alone in patients with hepatocellular carcinoma. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238858 Fri, 29 Jul 2011 04:00:00 +0100 5238858 http://www.medworm.com/index.php?rid=5388475&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002337%2Fabstract%3Frss%3Dyes Conclusion: Despite more restricted access to curative treatments, survival of elderly patients with hepatocellular carcinoma is comparable to that of younger patients. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388475 Thu, 28 Jul 2011 04:00:00 +0100 5388475 http://www.medworm.com/index.php?rid=5238856&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002313%2Fabstract%3Frss%3Dyes Conclusion: Patient survival after liver transplantation was influenced by low income, low educational level, and lack of access to quality health care. Prospective clinical studies are necessary to fully identify the impact of socioeconomic status on long-term health outcomes, and to propose an evidence-based guide to clinical intervention. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238856 Thu, 28 Jul 2011 04:00:00 +0100 5238856 http://www.medworm.com/index.php?rid=5238855&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002258%2Fabstract%3Frss%3Dyes Abstract: Background: The performance of transient elastography in primary biliary cirrhosis has yet to be fully established.Aim: To assess: (1) the performance of transient elastography in identifying significant fibrosis in primary biliary cirrhosis by comparison with surrogate markers (AST platelet ratio index (APRI), FIB-4, Fibroindex, Forns, aspartate aminotransferase/alanine aminotransferase ratio); (2) the correlation between liver stiffness and Mayo score prognostic index.Methods: One hundred and twenty patients with primary biliary cirrhosis were consecutively enrolled. The performance of each marker and of liver stiffness was compared with histological staging and METAVIR at time of liver biopsy.Results: The area under receiver operating characteristic (ROC) of liver stiffness we... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238855 Mon, 25 Jul 2011 04:00:00 +0100 5238855 http://www.medworm.com/index.php?rid=5080612&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002325%2Fabstract%3Frss%3Dyes Diabetes mellitus is one of the most prevalent chronic disorders worldwide. The World Health Organization estimates that there were 171 million people in the world with diabetes in the year 2000, with an estimated projected increase to 366 million by 2030. Diabetes is associated with reduced life expectancy, significant morbidity due to microvascular complications, increased risk of macrovascular complications (ischaemic heart disease, stroke and peripheral vascular disease), and diminished quality of life . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080612 Sun, 24 Jul 2011 23:00:00 +0100 5080612 http://www.medworm.com/index.php?rid=5080611&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002295%2Fabstract%3Frss%3Dyes For most people the strongest barrier against making the decision to undergo colonoscopy is the burden of cleaning the bowel and the fear of feeling pain during the procedure . Completeness of colonoscopy up to the caecum and the careful examination of the entire large bowel are the most important quality indicators of colonoscopy . Cleanliness of the bowel and patient sedation are prerequisites to perform an effective examination, to avoid missing significant neoplastic lesions . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080611 Sun, 24 Jul 2011 23:00:00 +0100 5080611 http://www.medworm.com/index.php?rid=5583198&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002283%2Fabstract%3Frss%3Dyes Conclusions: KB9520 induced apoptosis in cholangiocarcinoma by selectively acting on oestrogen receptor-β, suggesting that oestrogen receptor-β selective agonists may be a novel and effective therapeutic option for the medical treatment of intrahepatic cholangiocarcinoma. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5583198 Fri, 22 Jul 2011 04:00:00 +0100 5583198 http://www.medworm.com/index.php?rid=5388481&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002271%2Fabstract%3Frss%3Dyes Lactic acidosis (LA) may be observed in cirrhotics hepatitis B virus (HBV) patients with impaired liver function during Entecavir (ETV) treatment and Model for End stage Liver Disease (MELD) score has been suggested to directly correlate with LA development . However some recent studies reported a high efficacy and safety of ETV in decompensated cirrhosis. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388481 Fri, 22 Jul 2011 04:00:00 +0100 5388481 http://www.medworm.com/index.php?rid=5238865&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100226X%2Fabstract%3Frss%3Dyes We report possibly the first case of rectal GIST treated by Transanal Endoscopic Microsurgery (TEM) in combination with neoadjuvant therapy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238865 Fri, 22 Jul 2011 04:00:00 +0100 5238865 http://www.medworm.com/index.php?rid=5040706&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100051X%2Fabstract%3Frss%3Dyes Abstract: Background: The management of colorectal polyps (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5040706 Wed, 20 Jul 2011 18:00:45 +0100 5040706 http://www.medworm.com/index.php?rid=5040699&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002374%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5040699 Wed, 20 Jul 2011 18:00:44 +0100 5040699 http://www.medworm.com/index.php?rid=5525956&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002234%2Fabstract%3Frss%3Dyes Isolated small bowel tuberculosis (SBTB) is rare and it is difficult to confirm the diagnosis. Its symptoms are nonspecific and vague, and the endoscopic approach to the SB has been problematic. Moreover, distinguishing Crohn's disease from SBTB in areas that are endemic for TB is challenging . Yet the characteristic appearance of isolated SBTB has not been reported. We experienced a case of isolated SBTB that was diagnosed by CE and we report here on our findings. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525956 Wed, 20 Jul 2011 04:00:00 +0100 5525956 http://www.medworm.com/index.php?rid=5238861&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002131%2Fabstract%3Frss%3Dyes We report a case of gastrointestinal haemorrhage due to the extrusion of an intra variceal coil in a patient treated with sorafenib. Coil extrusions have already been reported after arterial embolization .A transjugular intrahepatic portosystemic shunt was performed in June 2007 as a preventive treatment for gastric variceal haemorrhage in a 49-year-old woman with alcoholic and hepatitis C cirrhosis. During this procedure a voluminous left gastric varice was embolized with two coils. A sorafenib treatment was begun in April 2009 for multifocal hepatocellular carcinoma, with a thrombosis of the intrahepatic stent. In October 2009 the patient was admitted for melaena and hematemesis. Upper gastrointestinal endoscopy showed grade III esophageal varices and a partial coil extrusion from gastri... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238861 Mon, 18 Jul 2011 04:00:00 +0100 5238861 http://www.medworm.com/index.php?rid=5238862&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002076%2Fabstract%3Frss%3Dyes We read with great interest the recent leading article on the characteristics of donor–recipient liver transplant matching recently performed in Italy published in the journal . We thank all the authors for the immense job performed. Although the positive effect on the outcome of balancing donor and recipient risk factors is well known , this is the first attempt to prospectively investigate on a national basis how donor and recipient factors are currently combined and how their interaction affects graft and patient survivals. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238862 Fri, 15 Jul 2011 04:00:00 +0100 5238862 http://www.medworm.com/index.php?rid=5238860&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002167%2Fabstract%3Frss%3Dyes Conclusion: These study results suggest that a previous anti-VEGF therapy decrease cetuximab efficiency. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238860 Fri, 15 Jul 2011 04:00:00 +0100 5238860 http://www.medworm.com/index.php?rid=5080613&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002246%2Fabstract%3Frss%3Dyes Autoimmune pancreatitis (AIP) is a well-defined clinical entity pathologically different from all the other forms of chronic pancreatitis. Since its first description, the concept of the disease has greatly changed over time. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080613 Thu, 14 Jul 2011 23:00:00 +0100 5080613 http://www.medworm.com/index.php?rid=5525964&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002210%2Fabstract%3Frss%3Dyes A 20-year-old man was admitted for acute abdominal pain and vomiting. He had no past medical history. Physical examination found right iliac fossa guarding. Haemoglobin level was 7.8g/dL. Computed tomography scan () depicted a characteristic target lesion indicating intestinal intussusceptions, and an intraluminal hypodense mass containing fluid. Laparotomy confirmed the intussusceptions; a polypoid mass was found at palpation of the ileum at the intussusception site. Because of the suspicion of neoplasia, an en-bloc ileocolic resection was performed rather than a simple reduction of the intussusception. At the opening of the specimen, an 8cm inverted, ecchymosed and ulcerated Meckel's diverticulum () was found. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525964 Wed, 13 Jul 2011 04:00:00 +0100 5525964 http://www.medworm.com/index.php?rid=5525963&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002209%2Fabstract%3Frss%3Dyes A 63-year-old woman was admitted to the emergency department with diffuse abdominal pain, distention, nausea, and vomiting. Physical examination revealed hyperactive bowel sounds, mild diffuse abdominal distention, and tenderness. Abdominal radiography showed a dilated small bowel with multiple air-fluid levels. The patient underwent an exploratory operation, where we discovered that the tip of the inflamed appendix had attached to the antimesenteric side of the ileum and had caused internal herniation (Fig. 1). As a result, obstruction and ischemic changes had developed at the herniated segments of the small bowel (Fig. 2). A dilatation was noted at the proximal segments of the ileum. The tip of the appendix was gently decomposed manually from the antimesenteric side, which eliminated the... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525963 Wed, 13 Jul 2011 04:00:00 +0100 5525963 http://www.medworm.com/index.php?rid=5388479&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002192%2Fabstract%3Frss%3Dyes A 46-year-old man was referred to our Institution for severe Crohn's colitis following azathioprine withdrawal. Symptoms and C-reactive protein levels moderately improved after a five-day course of methylprednisolone (0.8mg/kg/day). Abdominal magnetic resonance imaging showed colonic inflammation. Colonoscopy was performed and confirmed the presence of colonic lesions from Crohn's disease. Colonoscopy confirmed radiological findings with severe lesions mainly in the ascending colon, and the absence of colonic stricture. Routine chest radiography was performed on the next day and showed a large, round, air-filled image in the right hypochondrium (Fig. 1A), without any other abnormal finding. Computed tomography ruled out intestinal perforation, and confirmed a massive (12cm) expansion of th... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388479 Wed, 13 Jul 2011 04:00:00 +0100 5388479 http://www.medworm.com/index.php?rid=5238864&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002179%2Fabstract%3Frss%3Dyes We report a case of a 59-year-old woman who presented a possible IgG4-associated autoimmune hepatitis trigged by liver injury due to ciprofloxacin. Although the patient was an adult female with a clinical course evocative of an autoimmune disease, the diagnosis was initially not obvious due to normal serum gammaglobulin level. This patient was seen for jaundice, asthenia and pruritus. Symptoms started few days after the end of ciprofloxacin treatment (1000mg/day for 6 days) given for a urinary tract infection. She had no personal or family medical history; she denied drinking alcohol or taking other medications; there were no clinical signs of cirrhosis. Prothrombin time was normal, total bilirubin was moderately increased whilst signs of marked cytolysis were present (). Infections with h... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238864 Wed, 13 Jul 2011 04:00:00 +0100 5238864 http://www.medworm.com/index.php?rid=5209942&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002222%2Fabstract%3Frss%3Dyes We read with interest the letter by Grattagliano et al. in which the authors question the interpretation of the results of a previous randomized study, in which we showed a disappointing uptake of colorectal cancer (CRC) screening with guaiac-based faecal testing and especially colonoscopy, when the study population was directly invited by General Practitioners (GPs) . In detail, Grattagliano et al. suggested that the GPs involved in the study could have underperformed because of lack of training or established collaboration with other health professionals. Although we cannot completely rule out such a possibility, it should be clarified that every effort to minimize such a bias was undertaken in the study . In particular, all the involved GPs attended a pre-study course in which both gene... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209942 Wed, 13 Jul 2011 04:00:00 +0100 5209942 http://www.medworm.com/index.php?rid=5209929&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002180%2Fabstract%3Frss%3Dyes Abstract: Aim: To evaluate the prevalence of sleep disturbances in French patients with gastro-oesophageal reflux disease and the impact of gastro-oesophageal reflux disease treatment on sleep.Methods: A registry was compiled of all gastro-oesophageal reflux disease patients seen during a 2-week period by 1983 French primary care physicians. Data from the first two patients with nocturnal gastro-oesophageal reflux disease symptoms and gastro-oesophageal reflux disease-related sleep disturbances seen by each physician were derived from physician questionnaires and medical records. These patients completed a questionnaire during the initial consultation and after 1-month treatment.Results: A total of 33,391 patients were included in the study: physician questionnaires were available for 3269... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209929 Wed, 13 Jul 2011 04:00:00 +0100 5209929 http://www.medworm.com/index.php?rid=5238854&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002155%2Fabstract%3Frss%3Dyes Conclusions: This unblinded, randomized, pilot study suggests that treatment with half doses of albumin is effective in the prevention of paracentesis-induced circulatory dysfunction and its related clinical complications in cirrhotic patients with tense ascites treated by large volume paracentesis. If confirmed, these results could support a significant costs reduction in the management of ascites in cirrhotic patients. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238854 Mon, 11 Jul 2011 04:00:00 +0100 5238854 http://www.medworm.com/index.php?rid=5209935&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100209X%2Fabstract%3Frss%3Dyes Conclusion: The portal flow modulation induced by splenectomy or splenic transposition was effective in limiting early damage after extended liver resection. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209935 Fri, 08 Jul 2011 04:00:00 +0100 5209935 http://www.medworm.com/index.php?rid=5388483&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002106%2Fabstract%3Frss%3Dyes An 80-year-old man with a history of diabetes mellitus and hypertension, presented with worsening generalized pruritic eruption on his trunk and extremities for 2 weeks. Physical examination revealed widespread erythematoscaly plaques involving 80–90% of the total body surface (). There was no history of atopy or past liver disease. The patient had been treated with oral antihistamines and topical corticosteroid with slight improvement. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388483 Wed, 06 Jul 2011 04:00:00 +0100 5388483 http://www.medworm.com/index.php?rid=5388482&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002143%2Fabstract%3Frss%3Dyes A 65 year-old male was diagnosed with B-cell lymphoma in the head of the pancreas in 2001. Also in 2001, he underwent Tornado coil embolization of a right hepatic lobe pseudoaneurysm. In 2002, he received CHOP, Rituxan, and radiation, with complete response. In July 2010, he presented with one week of abdominal pain and jaundice. On admission, bilirubin was 11.4mg/dL (9.4mg/dL direct), and alkaline phosphatase 632U/L. Computed tomography scan of the abdomen was negative for recurrent lymphoma, but revealed migration of previously placed Tornado coils into the common bile duct. During ERCP, purulent bile consistent with cholangitis was draining through a patent sphincterotomy. Cholangiogram revealed two, serpentine, metallic coils in the mid common bile duct (). The coils were successfully ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388482 Wed, 06 Jul 2011 04:00:00 +0100 5388482 http://www.medworm.com/index.php?rid=5238867&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002064%2Fabstract%3Frss%3Dyes A 56-year-old male with hepatitis B virus-related cirrhosis underwent liver transplantation. At transplantation the arterial inflow to the liver graft was achieved using an iliac artery conduit anastomosed to the infrarenal aorta and to the hepatic artery (HA) of the graft. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238867 Wed, 06 Jul 2011 04:00:00 +0100 5238867 http://www.medworm.com/index.php?rid=5238852&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100212X%2Fabstract%3Frss%3Dyes Conclusion: EUS-FNA using 22-gauge needle distinguished benign from malignant pancreatic mass with >90% of accuracy, regardless of the location. Hence, it was helpful for the clinical diagnosis of AIP, however not providing satisfactory samples for the histological diagnosis of AIP. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238852 Wed, 06 Jul 2011 04:00:00 +0100 5238852 http://www.medworm.com/index.php?rid=5209931&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002015%2Fabstract%3Frss%3Dyes Abstract: Background: Repeated attempts at cannulating the papilla of Vater and “needle-knife” precut sphincterotomy are independent risk factors for post-ERCP pancreatitis. Whether precut alone or repeated attempts at cannulation is the culprit factor in the development of post-ERCP pancreatitis remains controversial.Aim: To retrospectively assess the role of precutting and multiple cannulation in the occurrence of post-ERCP pancreatitis in a consecutive series of patients with bile stone disease.Methods: 2004 patients who had undergone endoscopic retrograde cholangio-pancreatography over a 9-year period for bile stones were evaluated. Pancreatitis rate was assessed in relation to the number of cannulation attempts ( (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209931 Wed, 06 Jul 2011 04:00:00 +0100 5209931 http://www.medworm.com/index.php?rid=5209928&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002088%2Fabstract%3Frss%3Dyes Conclusion: Continent ileostomy carries a significant risk of non-severe complications. In selected patients, it represents a valuable alternative to an end ileostomy, in particular when restorative proctocolectomy has failed. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209928 Thu, 30 Jun 2011 04:00:00 +0100 5209928 http://www.medworm.com/index.php?rid=5209941&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002039%2Fabstract%3Frss%3Dyes We read with interest the article by Perri et al. dealing with different approaches to improve the adherence to colonoscopy within the colorectal cancer (CRC) screening. We were greatly astonished to read, in the introduction, that “the main reason for the low acceptance of CRC screening in Italy seems to be related to the lack of screening recommendations given by general practitioners (GPs)”. These conclusions were based on the questionable interpretation of the results of a recent study aimed to compare screening programmes (colonoscopy vs FOBT). The authors conclude that (i) the great variability in colonoscopy compliance was likely due to the different degree of GPs convincement in regard to the utility of colonoscopy for screening, and that (ii) a 30% attendance rate represents t... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209941 Mon, 27 Jun 2011 04:00:00 +0100 5209941 http://www.medworm.com/index.php?rid=5209940&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002027%2Fabstract%3Frss%3Dyes We have greatly appreciated the comments of Savarino et al. They very nicely commented that esophageal multichannel impedance-pH has greatly improved the current knowledge of the complex pathophysiology of GERD. We cannot agree more. Likewise, we strongly believe that this new technology represents an important breakthrough that has allowed a more focused management of patients, especially those with non-erosive esophagitis. What we also would like to point out is that parallel improvement of this technology has allowed us, like nothing before, to better comprehend the presentation of those classes of patients for which non-erosive esophagitis, functional heartburn, and gastroesophageal reflux disease with acid, non-acid or weakly acid reflux represent a wide spectrum of complex pathology ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209940 Thu, 23 Jun 2011 04:00:00 +0100 5209940 http://www.medworm.com/index.php?rid=5209933&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002003%2Fabstract%3Frss%3Dyes Conclusions: In a large PSC population, a high prevalence of concomitant immune-mediated diseases was found. IBD occurred more often in early-acquired PSC, and the other immune-mediated diseases more often in later-acquired PSC. No effect on outcome was found for non-IBD immune mediated disease. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209933 Thu, 23 Jun 2011 04:00:00 +0100 5209933 http://www.medworm.com/index.php?rid=5040700&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002040%2Fabstract%3Frss%3Dyes Digestive cancer accounts for a quarter of all cancers and considerable knowledge of the particular features of these disorders is required for correct treatment. Digestive oncology (DO) is a major field of activity for hepato-gastroenterologists (HGE), who are involved at all stages, from screening to diagnosis, follow-up, tumour evaluation and palliative treatment. HGE have also recently been recruited to multidisciplinary teams, due to their considerable competence in the management of digestive cancers. Overall DO accounts for more than 50% of all admissions to most gastroenterology (GI) departments. In Belgium, France and Germany, HGE with specific, recognized competence are allowed to administer chemotherapy and targeted therapies. In these countries, such competence is considered to... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5040700 Wed, 22 Jun 2011 23:00:00 +0100 5040700 http://www.medworm.com/index.php?rid=5525942&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100168X%2Fabstract%3Frss%3Dyes Abstract: Whilst the current treatment of achalasia is well understood, the management of other oesophageal disorders is still debated, as these are rare and the literature on their clinical presentation and management is scarce. The following review describes the clinical presentation of oesophageal motility disorders, gives an overview of their diagnosis in light of the new advances in oesophageal motility testing, and provides an evidence-based approach to their management with different forms of treatment (medical, endoscopic, and minimally invasive). (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5525942 Wed, 22 Jun 2011 04:00:00 +0100 5525942 http://www.medworm.com/index.php?rid=5238853&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001678%2Fabstract%3Frss%3Dyes Abstract: Background: The aetiological factors of hepatocellular carcinoma may vary over time.Aims: The study assessed the potential impact of the aetiological factors on the effectiveness of surveillance in real-world patients.Methods: Multicentre, cross-sectional study enrolling consecutive hepatocellular carcinoma cases during a six month period.Results: 1733 cases (1311 prevalent and 422 incident) were recruited (mean age 68.6 years; 46.1% cases over 70 years; 73.9% males; 95.3% with cirrhosis); 63.0% were hepatitis C virus positive and 23.7% were virus negative. Amongst incident HCCs, 34.5% were single ≤3cm and 54.4% met the Milan criteria; 61.6% were diagnosed during surveillance; virus negative patients showed the lowest rate of surveillance (51.0%). Surveillance was an independen... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238853 Mon, 20 Jun 2011 04:00:00 +0100 5238853 http://www.medworm.com/index.php?rid=5209934&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001605%2Fabstract%3Frss%3Dyes Conclusions: In chronic hepatitis C, selective expansion of peripheral T-regs in patients with normal aminotransferases and advanced disease suggests that, though a continual low level inflammation does not prevent liver disease progression, once cirrhosis has developed it may represent an attempt to prevent immuno-mediated decompensation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209934 Mon, 20 Jun 2011 04:00:00 +0100 5209934 http://www.medworm.com/index.php?rid=5209932&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001666%2Fabstract%3Frss%3Dyes Conclusions: Pancreatic cysts are associated with cysts in other abdominal organs in 54.8% patients. The prevalence of serous cysts was not higher amongst individuals with multiple organ cysts compared to those with only pancreatic cysts. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209932 Fri, 17 Jun 2011 04:00:00 +0100 5209932 http://www.medworm.com/index.php?rid=5080635&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001563%2Fabstract%3Frss%3Dyes A 35-year-old male patient was admitted for mild abdominal pain. He had no history of operation, medication, or any injury. Physical examination and laboratory results were normal. Portal vein (PV) Doppler ultrasound showed a shunt between middle hepatic vein (HV) and left branch of PV. Angiography of magnetic resonance imaging of the liver revealed aneurysms and shunts between left PV and middle HV (Fig. 1). Three shunts were seen between segment 2 and segment 3 branches of the left PV and the left HV (Fig. 2). This case was compatible with third type that defines a connection between peripheral portal and hepatic veins through an aneurysm . Minimal hepatic encephalopathy is excluded by psychometric tests including trailmaking tests and Wechsler Adult Intelligence Scale. Plasma ammonia le... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080635 Wed, 15 Jun 2011 23:00:00 +0100 5080635 http://www.medworm.com/index.php?rid=5209930&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001733%2Fabstract%3Frss%3Dyes Abstract: Aim: Prospective evaluation of the new 0.025in. Visiglide® guidewire to facilitate endoscopic retrograde cholangiopancreaticography using the Olympus V-scope.Materials and methods: Interventional endoscopic retrograde cholangiopancreaticography was performed in 9 patients with the Olympus V-scope and the 0.025in. Visiglide® guidewire (VS group), whilst 9 other patients underwent endoscopic retrograde cholangiopancreaticography with a conventional Olympus duodenoscope using 0.035in. conventional guidewires (controls). Exchange time of accessories, X-ray time, dose and endoscopic retrograde cholangiopancreaticography examination time were investigated.Results: The VS group showed a significantly lower exchange time of endoscopic retrograde cholangiopancreaticography accessories (... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209930 Wed, 15 Jun 2011 04:00:00 +0100 5209930 http://www.medworm.com/index.php?rid=5238866&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581100171X%2Fabstract%3Frss%3Dyes Many small rectal neuroendocrine tumours (NET) are excised at endoscopy without prior knowledge of their metastatic potential. Although main risk factors for lymph node metastases are tumour size, invasion of the muscularis propria and lymphovascular infiltration, lesions smaller than 10mm can also metastasize. A 63-year-old woman was referred to our hospital reporting evacuation difficulties. Colonoscopy revealed a submucosal nodule smaller than 1cm at the lower rectum. The histological diagnosis of the biopsy specimen was NET G1 (WHO 2010). Endorectal ultrasonography demonstrated a 7-mm hypoechoic lesion on the submucosal layer (, arrow) with one swollen lymph node close to the lesion (, arrowhead). Thoracic and abdominal CT detected no distant metastasis. After submucosal injection of m... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5238866 Mon, 13 Jun 2011 04:00:00 +0100 5238866 http://www.medworm.com/index.php?rid=5040702&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811002052%2Fabstract%3Frss%3Dyes A famous quotation of Denis Waitley says, “Never become so much of an expert that you stop gaining expertise. View life as a continuous learning experience”. In the last few years, there has been a notion that the majority of clinical questions regarding the every day practice of endoscopic ultrasound (EUS) have been resolved. Fabbri et al. in their interesting manuscript published in this issue of Digestive and Liver Disease refuted that notion. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5040702 Sun, 12 Jun 2011 23:00:00 +0100 5040702 http://www.medworm.com/index.php?rid=5040701&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001691%2Fabstract%3Frss%3Dyes Coeliac disease (CD) is an autoimmune disorder triggered by the ingestion of gluten-containing grains in genetically susceptible individuals. It is currently recognized that CD can manifest with a wide range of clinical presentations, including the typical malabsorption syndrome (chronic diarrhoea, weight loss, abdominal distension) and a spectrum of symptoms potentially affecting any organ or body system . The burden of illness related to CD is doubtless higher than previously thought and there is growing interest on the social dimension of this condition. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5040701 Sun, 12 Jun 2011 23:00:00 +0100 5040701 http://www.medworm.com/index.php?rid=5209939&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001721%2Fabstract%3Frss%3Dyes We read with great interest the review article by Weber et al. on current applications of new methodologies in gastroesophageal reflux testing. The authors assessed almost all the available literature published in this field after the advent of wireless capsule pH and impedance-pH monitoring and discussed the clinical applicability, advantages and limits of these new techniques. In particular, they reported that the major advantage of impedance-pH testing relies in the detection of weakly acidic reflux (WAR), that allows clinicians to identify more patients whose reflux is responsible for their symptoms and quoted several investigations, mainly performed in Gastro-oesophageal Reflux Disease (GORD) patients without endoscopic assessment, in order to support their conclusions . However, we b... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209939 Fri, 10 Jun 2011 04:00:00 +0100 5209939 http://www.medworm.com/index.php?rid=5209945&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001642%2Fabstract%3Frss%3Dyes A 64-year-old man was referred for recurrent episodes of melena. He was taking low dose aspirin for ischaemic heart disease and he had history of a small facial melanoma resected five years earlier, without any further follow up. Gastroscopy and colonoscopy were unrevealing. Capsule endoscopy (Pill cam SB 2; Given Imaging, Yoqneam, Israel) disclosed a bleeding polypoid lesion with diffuse prominent villi with whitish discoloured tips at the proximal jejunum (a). The patient underwent single port laparoscopy and the involved jejunal portion was resected. Dissection of the specimen revealed a hard, semi-circumferential, ulcerated, polypoid lesion, 10cm×5cm in size (b). Histopathology (a, Haematoxylin & eosin staining, ×20) with immunohistochemistry for Melan A (b, ×400), a melanoma specif... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209945 Mon, 06 Jun 2011 04:00:00 +0100 5209945 http://www.medworm.com/index.php?rid=5209944&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001599%2Fabstract%3Frss%3Dyes A 28-year-old man presented with massive gastrointestinal haemorrhage and hypovolemic shock. His haemoglobin level dropped to 5g/dl over a six-hour period. Emergency upper endoscopy to the second part of the duodenum showed no abnormalities. Digital subtraction visceral angiography was performed. Superior mesenteric arteriography revealed bleeding from a marginal branch of the ileocolic artery (Fig. 1A, arrow) that supplied the distal ileum, consistent with small bowel angiodysplasia. Superselective mesenteric embolization with gelatin sponges was performed (Fig. 1B, arrow). (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209944 Mon, 06 Jun 2011 04:00:00 +0100 5209944 http://www.medworm.com/index.php?rid=5209937&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001617%2Fabstract%3Frss%3Dyes Abstract: Aim: To evaluate the characteristics of postoperative relapse, predictive factors and time to relapse after curative surgery for well-differentiated neuroendocrine tumours of the ileum, without hepatic or other distant metastases.Methods: Clinical data of patients entered into the Groupe d’étude des Tumeurs Endocrines database were collected and analysed retrospectively to identify factors predictive of relapse.Results: Among 100 patients followed for a median of 56.5 (range 1–290) months, 42 relapsed after a median follow-up of 57.5 (range 6–176) months, with liver lesions in 27 (64.3%). Median disease-free survival (Kaplan–Meier) was 88 months (95% confidence interval 72–115). Disease-free survival was shorter for emergency surgery patients (p (Source: Digestive and ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209937 Mon, 06 Jun 2011 04:00:00 +0100 5209937 http://www.medworm.com/index.php?rid=5209927&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001654%2Fabstract%3Frss%3Dyes Conclusions: AGA-positivity is often persistent. Overt coeliac disease is seldom found behind persistent AGA-positivity, but this characteristic is associated with mucosal inflammation and gastrointestinal symptoms at least in HLA-positive individuals. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209927 Mon, 06 Jun 2011 04:00:00 +0100 5209927 http://www.medworm.com/index.php?rid=5080632&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001629%2Fabstract%3Frss%3Dyes In conclusion, we report a fatal case of gastric bleeding during sorafenib treatment for HCC recurrence after liver transplantation. Although more data are needed, the concern of gastrointestinal bleeding should be weighted during sorafenib therapy for HCC recurrence after OLT. Sorafenib treatment should be stopped if there is evidence of digestive bleeding. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080632 Sun, 05 Jun 2011 23:00:00 +0100 5080632 http://www.medworm.com/index.php?rid=5080631&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001630%2Fabstract%3Frss%3Dyes We report here a case of ALA rupture into the stomach, leading to formation of hepatogastric fistula which was successfully managed conservatively. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080631 Sun, 05 Jun 2011 23:00:00 +0100 5080631 http://www.medworm.com/index.php?rid=5080624&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001526%2Fabstract%3Frss%3Dyes Conclusions: Use of sedation has become a standard practise during GI endoscopy in Italy. Pattern varies for each type of procedure. Pulse oximetry is the most employed system of monitoring. Administration of propofol is still directed by anaesthesiologists. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080624 Sun, 05 Jun 2011 23:00:00 +0100 5080624 http://www.medworm.com/index.php?rid=4878040&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001927%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=4878040 Mon, 30 May 2011 17:11:36 +0100 4878040 http://www.medworm.com/index.php?rid=5388464&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001484%2Fabstract%3Frss%3Dyes Abstract: A number of guidelines on the management of gastro-intestinal stromal tumours (GISTs) have been published, mostly based on expert consensus. However, these guidelines have generally failed to address the specific problem of GISTs of limited size (i.e. those measuring a few centimetres in diameter) with which gastroenterologists are increasingly confronted. The aim of the present work was to draw up proposals for the diagnosis and treatment of GISTs measuring less than 5cm in diameter. For this purpose, a number of practical questions were put to a panel of French experts. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5388464 Mon, 30 May 2011 04:00:00 +0100 5388464 http://www.medworm.com/index.php?rid=5209938&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001587%2Fabstract%3Frss%3Dyes A 55-year-old man presented to our hospital with gastrointestinal bleeding. Standard oesophagogastroduodenoscopy and colonoscopy were performed, but the source of bleeding could not be identified. Contrast enhanced CT was performed and an intussusception was suspected in the small bowel. Meckel scan result was negative. Virtual enteroscopy (VE) was then performed to check for the presence of a leading lesion. The depicted small bowel is shown in 3D overview (Fig. 1a) and dissection view (Fig. 1b). The small bowel was 543cm long on VE. An 8cm long pedunculated polypoid lesion was found in the ileum 130cm from the ileocecal valve (asterisk in Fig. 1b). The stalk and the head are indicated by arrow and arrowhead, respectively (Fig. 1c and d). According to the results of VE, retrograde single ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209938 Mon, 30 May 2011 04:00:00 +0100 5209938 http://www.medworm.com/index.php?rid=5209926&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001277%2Fabstract%3Frss%3Dyes Abstract: Background: Literature suggests early post-percutaneous endoscopic gastrostomy (PEG) feeding is as safe as delayed feeding. No consensus exists regarding feeding initiation after PEG placement. We performed a national survey to assess current practice regarding feeding initiation after PEG placement as well as clinical and practitioner based factors associated with early or delayed feeding.Methods: A survey assessing feeding initiation in general ward and intensive care unit patients, current literature knowledge, motility agent use, number of PEG placed per year, along with physician demographics was emailed to 5256 gastroenterologists. Statistical analysis was done using SAS software (V.9).Results: 28% of gastroenterologists responded. Amongst respondents, 59% were private cons... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209926 Mon, 30 May 2011 04:00:00 +0100 5209926 http://www.medworm.com/index.php?rid=5080630&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001551%2Fabstract%3Frss%3Dyes We report herein a case of intra- and retroperitoneal endoscopic rectal perforation associated with bilateral pneumothorax, successfully treated medically. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080630 Sun, 29 May 2011 23:00:00 +0100 5080630 http://www.medworm.com/index.php?rid=5080629&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001502%2Fabstract%3Frss%3Dyes We report a case of hepatotoxicity related to the use of Lycium barbarum (Goji), which has not been reported before. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080629 Sun, 29 May 2011 23:00:00 +0100 5080629 http://www.medworm.com/index.php?rid=5080628&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001514%2Fabstract%3Frss%3Dyes A previously healthy 40-year-old man presented to our hospital with a 1-month history of epigastric pain and anorexia. He denied fever, weight loss, skin rash or lymphadenopathy. His past medical history was unremarkable. Physical examination was normal except for epigastric tenderness. Laboratory work-up was normal, including haemoglobin levels (12.5g/dl). Upper endoscopy showed an irregularly ulcerated, nodular, edematous and friable mass from the mid body to antrum of the stomach (A). A biopsy specimen showed moderate to severe active chronic gastritis with a dense lympho-plasmacytic infiltrate in the gastric mucosa, but no evidence of malignancy. Serological tests for syphilis revealed the rapid-plasma-reagin (RPR) and the Treponema pallidum (TP) haemagglutination assay (TPHA) were bot... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5080628 Sun, 29 May 2011 23:00:00 +0100 5080628 http://www.medworm.com/index.php?rid=5209936&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865811001496%2Fabstract%3Frss%3Dyes Conclusion: Ninety-seven percent of gastric metastasis from breast cancers are derived from invasive lobular carcinoma. Seventy-nine percent of these are HER+ and comparison with the original histopathological slides of primary breast carcinoma should be performed to differentiate gastric metastasis from primary gastric carcinoma. Peritoneal carcinomatosis accompanied gastric metastasis in almost half the cases in this series and treatment was generally chemotherapy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=5209936 Fri, 27 May 2011 04:00:00 +0100 5209936