MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Digestive and Liver Disease' source. Sat, 20 Mar 2010 14:19:11 +0100 http://www.medworm.com/index.php?rid=3344265&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000678%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344265 Tue, 09 Mar 2010 14:34:09 +0100 3344265 http://www.medworm.com/index.php?rid=3344272&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000460%2Fabstract%3Frss%3Dyes Hepatitis C is a world pandemic with more than 175 million people affected world wide. As a leading cause of cirrhosis and hepatocellular carcinoma it is a major health problem. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344272 Tue, 02 Mar 2010 00:00:00 +0100 3344272 http://www.medworm.com/index.php?rid=3344271&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000459%2Fabstract%3Frss%3Dyes We report the evidence-based Italian Association for the Study of Liver guidelines for the appropriate diagnosis and management of patients with nonalcoholic fatty liver disease in clinical practice and its related research agenda.The prevalence of nonalcoholic fatty liver disease varies according to age, gender and ethnicity. In the general population, the prevalence of nonalcoholic fatty liver disease is about 25% and the incidence is of two new cases/100 people/year. 2–3% of individuals in the general population will suffer from nonalcoholic steatohepatitis. Uncomplicated steatosis will usually follow a benign course. Individuals with nonalcoholic steatohepatitis, however, have a reduced life expectancy, mainly owing to vascular diseases and liver-related causes. Moreover, steatosis h... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344271 Mon, 22 Feb 2010 00:00:00 +0100 3344271 http://www.medworm.com/index.php?rid=3344266&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000198%2Fabstract%3Frss%3Dyes It is my great pleasure to present in this issue of Digestive and Liver Disease, Part I of the 2010 Mini-Symposium on Cholangiocyte Pathophysiology, for which I have gladly accepted the role of Guest Editor. For this collection of articles, the Editorial Board has invited an impressive line-up of renowned international experts to write comprehensive and up-to-date reviews on a wide range of topics centered on cholangiocyte proliferation, differentiation, and mechanisms of disease. To all the dedicated Authors whose efforts made this series possible I would like to extend the gratitude of the Editorial Board, and congratulate them for the outstanding quality of their manuscripts. I am confident that these articles will benefit both researchers and clinicians alike, and I look forward to enr... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344266 Mon, 22 Feb 2010 00:00:00 +0100 3344266 http://www.medworm.com/index.php?rid=3344267&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000095%2Fabstract%3Frss%3Dyes Abstract: Cholangiocytes are the epithelial cells that line the biliary tree; they are the target of chronic diseases termed cholangiopathies, which represent a daily challenge for clinicians, since definitive medical treatments are not available yet.It is generally accepted that the progression of injury in the course of cholangiopathies, and promotion and progression of cholangiocarcinoma are at least in part due to the failure of the cholangiocytes’ mechanisms of adaptation to injury.Recently, several studies on the pathophysiology of the biliary epithelium have shed some light on the mechanisms that govern cholangiocyte response to injury. These studies provide novel information to help interpret some of the clinical aspects of cholangiopathies and cholangiocarcinoma; the purpose of ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344267 Thu, 18 Feb 2010 00:00:00 +0100 3344267 http://www.medworm.com/index.php?rid=3344268&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000125%2Fabstract%3Frss%3Dyes Abstract: Bile duct epithelial cells (i.e., cholangiocytes), which line the intrahepatic biliary epithelium, are the target cells in a number of human cholestatic liver diseases (termed cholangiopathies). Cholangiocyte proliferation and death is present in virtually all human cholangiopathies. A number of recent studies have provided insights into the key mechanisms that regulate the proliferation and function of cholangiocytes during the pathogenesis of cholestatic liver diseases. In our review, we have summarised the most important of these recent studies over the past 3 years with a focus on those performed in the animal model of extrahepatic bile duct ligation. In the first part of the review, we provide relevant background on the biliary ductal system. We then proceed with a general d... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344268 Mon, 15 Feb 2010 00:00:00 +0100 3344268 http://www.medworm.com/index.php?rid=3268231&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086581000023X%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268231 Sat, 13 Feb 2010 14:18:01 +0100 3268231 http://www.medworm.com/index.php?rid=3344273&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000411%2Fabstract%3Frss%3Dyes Colonoscopy is currently regarded as the “gold standard” for diagnosing diseases of colon and rectum; it also plays a key role in colorectal cancer screening, as either a primary approach in average-risk subjects or a second level test in asymptomatic individuals with positive faecal occult test or abnormal findings at CT colonography. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344273 Mon, 08 Feb 2010 00:00:00 +0100 3344273 http://www.medworm.com/index.php?rid=3344270&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000101%2Fabstract%3Frss%3Dyes Abstract: Polycystic liver diseases (PCLDs) are genetic disorders with heterogeneous etiologies and a range of phenotypic presentations. PCLD exhibits both autosomal or recessive dominant pattern of inheritance and is characterized by the progressive development of multiple cysts, isolated or associated with polycystic kidney disease, that appear more extensive in women. Cholangiocytes have primary cilia, functionally important organelles (act as mechanosensors) that are involved in both normal developmental and pathological processes. The absence of polycystin-1, 2, and fibrocystin/polyductin, normally localized to primary cilia, represent a potential mechanism leading to cyst formation, associated with increased cell proliferation and apoptosis, enhanced fluid secretion, abnormal cell–... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344270 Mon, 08 Feb 2010 00:00:00 +0100 3344270 http://www.medworm.com/index.php?rid=3268235&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000046%2Fabstract%3Frss%3Dyes Digestive endocrine tumours (dETs) are relatively rare neoplasms occurring in 2.5–5 cases/100,000 persons . They are usually considered as a heterogeneous disease, in terms of both biological and clinical features. Disease behaviour and patients’ prognosis are affected by several risk factors, such as the primary tumour site, the presence and the spread of metastases, the proliferative activity assessed by Ki67 . The expression of somatostatin receptors (sstr) has also been reported to be a factor related with prognosis, with patients expressing sstr2 and sstr5 experiencing a better outcome . This latter feature not only is a prognostic factor, but also plays a crucial role for the management of patients with dETs. In fact, the presence of sstr is the rational basis for treatment with ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268235 Mon, 01 Feb 2010 00:00:00 +0100 3268235 http://www.medworm.com/index.php?rid=3268234&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809004472%2Fabstract%3Frss%3Dyes Coeliac disease (CD) is a permanent intolerance to ingested gluten in genetically predisposed individuals presenting HLA DQ2 or DQ8 haplotype, with a prevalence of 1 to 100–200 individuals. The pathophysiological grounds of CD are thought to be of autoimmune origin, and there is ample evidence showing a strong relationship with other autoimmune disorders such as diabetes mellitus type 1, autoimmune thyroiditis and other conditions . Moreover, in recent years case reports and case series have suggested the possibility of an association between CD and inflammatory bowel diseases (IBDs) . In this issue of Digestive and Liver Disease Casella et al. assessed the prevalence of CD in a large series of Italian patients with IBD, and found a low (0.5%) result, lower than in the general population... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268234 Mon, 01 Feb 2010 00:00:00 +0100 3268234 http://www.medworm.com/index.php?rid=3344269&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865810000034%2Fabstract%3Frss%3Dyes Abstract: Cholangiocarcinoma is commonly considered a rare cancer. However, if we consider the hepato-biliary system a single entity, cancers of the gallbladder, intra-hepatic and extra-hepatic biliary tree altogether represent approximately 30% of the total with incidence rates close to that of hepatocellular carcinoma, which is the third most common cause of cancer-related death worldwide. In addition, cholangiocarcinoma is characterized by a very poor prognosis and virtually no response to chemotherapeutics; radical surgery, the only effective treatment, is not frequently applicable because late diagnosis. Biomarkers for screening programs and for follow-up of categories at risk are under investigation, however, currently none of the proposed markers has reached clinical application. Fo... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344269 Mon, 25 Jan 2010 00:00:00 +0100 3344269 http://www.medworm.com/index.php?rid=3177294&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809004770%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177294 Sat, 16 Jan 2010 14:16:20 +0100 3177294 http://www.medworm.com/index.php?rid=3116854&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809004514%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116854 Thu, 24 Dec 2009 14:14:20 +0100 3116854 http://www.medworm.com/index.php?rid=3116873&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809004435%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116873 Mon, 14 Dec 2009 00:00:00 +0100 3116873 http://www.medworm.com/index.php?rid=3116858&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809004290%2Fabstract%3Frss%3Dyes Colonoscopy with removal and pathologic assessment of all polyps is frequently performed in patients at risk for colorectal cancer. Surveillance intervals are then determined based on quantity and size of adenomatous polyps. While colonoscopy serves as the current gold standard for colon cancer prevention and diagnosis, there is an inherent miss rate with the procedure. For example, 5% of patients diagnosed with colorectal cancer had a recent colonoscopy that failed to detect the malignancy . Additionally, tandem colonoscopy studies have shown an adenoma miss rate of 2.1% for adenomas >10mm, 13% for adenomas 5–10mm, and 26% for adenomas of 1–5mm . Several factors have been shown to contribute to miss rates including poor bowel preparation, failure to reach the lesion, flat or depressed... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116858 Wed, 02 Dec 2009 00:00:00 +0100 3116858 http://www.medworm.com/index.php?rid=3116857&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809004289%2Fabstract%3Frss%3Dyes Colorectal cancer (CRC) is a public health problem in most developed countries. It is potentially curable in its early stages, but a relevant proportion of patients still presents with or ultimately develops metastatic disease. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116857 Wed, 02 Dec 2009 00:00:00 +0100 3116857 http://www.medworm.com/index.php?rid=3268242&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002771%2Fabstract%3Frss%3Dyes Conclusion: Using a fibrinogen-thrombin-collagen sponge patch may reduce bile leaks from the cut surface of the liver during adult right lobe split liver transplants. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268242 Fri, 13 Nov 2009 00:00:00 +0100 3268242 http://www.medworm.com/index.php?rid=2964892&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003995%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964892 Fri, 06 Nov 2009 14:15:40 +0100 2964892 http://www.medworm.com/index.php?rid=3344282&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900396X%2Fabstract%3Frss%3Dyes The corresponding author regrets that author D. Atasoy's name was incorrectly spelled in the original article. The complete and corrected list of authors are given. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344282 Mon, 02 Nov 2009 00:00:00 +0100 3344282 http://www.medworm.com/index.php?rid=3177299&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002412%2Fabstract%3Frss%3Dyes Abstract: Moxifloxacin has been used in the first-line treatment of Helicobacter pylori infection. The optimal dosage and duration have not been assessed.Aim: To evaluate the effectiveness of moxifloxacin, amoxicillin and esomeprazole in four regimens, in previously untreated patients infected by H. pylori.Methods and patients: Patients were randomly assigned to: esomeprazole 20mg b.i.d., amoxicillin 1g b.i.d., and one of each of the four following dosages of moxifloxacin: moxifloxacin 400mg b.i.d. for 10 days (EAM800×10), moxifloxacin 400mg b.i.d. for 7 days (EAM800×7), moxifloxacin 400mg b.i.d. for 5 days (EAM800×5), moxifloxacin 400mg o.i.d. for 10 days (EAM400×10). Eradication was assessed by the Urea Breath Test (UBT) 2 months following the end of therapy.Results: Ninety-four, 102... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177299 Wed, 21 Oct 2009 00:00:00 +0100 3177299 http://www.medworm.com/index.php?rid=3177306&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003661%2Fabstract%3Frss%3Dyes Conclusions: After an episode of acute necrotizing pancreatitis treated without surgery, the endocrine and exocrine function is not frequently impaired after long-term follow-up. Reduction in exocrine function is transient and complete recovery is achieved in all patients within a few years. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177306 Fri, 16 Oct 2009 00:00:00 +0100 3177306 http://www.medworm.com/index.php?rid=2964893&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003934%2Fabstract%3Frss%3Dyes When in mid 2008 I took over the role of Editor-in-Chief of Digestive and Liver Disease and started working to create the new editorial team, I was well aware that one year was too short a time for the new editorial policy to have an impact on the Journal. Whether a difference is indeed visible and whether it has been for the better may be debated among our readers, however I believe it is still too early to draw conclusions. The year 2009, which is coming to a close, has been for myself and for the whole editorial staff a year of study, investigation and training, in which we have focused on what we believe should be the fundamental features of Digestive and Liver Disease in order to provide a continually improving service to science. Here I would like to share with our readers a few thou... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964893 Thu, 15 Oct 2009 00:00:00 +0100 2964893 http://www.medworm.com/index.php?rid=3268245&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003302%2Fabstract%3Frss%3Dyes Conclusions: Immunohistochemistry revealed that somatostatin receptors were highly expressed in both primary and metastatic gastro-entero-pancreatic endocrine tumours with heterogeneous staining distribution. It proved to be a reliable technique even in small tumour samples. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268245 Mon, 12 Oct 2009 00:00:00 +0100 3268245 http://www.medworm.com/index.php?rid=2873599&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003776%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873599 Fri, 09 Oct 2009 09:29:44 +0100 2873599 http://www.medworm.com/index.php?rid=3344276&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003673%2Fabstract%3Frss%3Dyes Abstract: Background: Fibrosis in liver transplant recipients with recurrent HCV is fast, yet, different patterns of progression are recognized.Aims: To investigate histological findings associated with maintenance ribavirin monotherapy in patients with recurrent HCV transplanted ≥4 years earlier.Methods: 14 recipients at high risk of progression (fibrosis progression rate >0.33 units/year and/or persistently elevated ALT) were assigned to receive ribavirin for 3 years. 11 patients at lower risk of progression (FPR ≤0.33 units/year and normal ALT) as controls. Biopsies were obtained yearly since transplant and 7 consecutive biopsies were evaluated.Results: Improved necroinflammation (reduction ≥2 grading) was observed in 7 treated with ribavirin and 3 untreated patients, while 1 and ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344276 Fri, 09 Oct 2009 00:00:00 +0100 3344276 http://www.medworm.com/index.php?rid=3177296&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003624%2Fabstract%3Frss%3Dyes This article briefly reviews clinical aspects of autoimmune pancreatitis with a focus on its diagnostic imaging and management. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177296 Mon, 05 Oct 2009 00:00:00 +0100 3177296 http://www.medworm.com/index.php?rid=3268236&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003612%2Fabstract%3Frss%3Dyes Conclusions: Overall we found a lower risk of celiac disease in our cohort of inflammatory bowel disease patients than in the general population; prevalence of celiac disease was higher in patients with ulcerative colitis than in those with Crohn's disease. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268236 Mon, 28 Sep 2009 00:00:00 +0100 3268236 http://www.medworm.com/index.php?rid=3268233&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003375%2Fabstract%3Frss%3Dyes Abstract: This review article aims to discuss the aetiology, pathophysiology, clinical presentation, diagnostic workup and management of portal vein thrombosis, either as a primary vascular liver disease in adults and children, or as a complication of liver cirrhosis. In addition, indications and limits of anticoagulant therapy are discussed in detail. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268233 Tue, 22 Sep 2009 00:00:00 +0100 3268233 http://www.medworm.com/index.php?rid=3177295&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003351%2Fabstract%3Frss%3Dyes This article reports the recommendations for the treatment of hepatitis C virus infection on an individual basis, drafted by experts of three scientific societies. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177295 Mon, 14 Sep 2009 00:00:00 +0100 3177295 http://www.medworm.com/index.php?rid=2779996&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003405%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2779996 Thu, 10 Sep 2009 16:32:12 +0100 2779996 http://www.medworm.com/index.php?rid=2964896&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003296%2Fabstract%3Frss%3Dyes Abstract: The irritable bowel syndrome (IBS) is a chronic abdominal symptom complex that is heterogeneous in terms of its clinical presentation and underlying pathophysiology and pathogenesis. It is now established that enteric infection can trigger the syndrome in at least a subset of patients. In addition, there is growing evidence of low grade inflammation and immune activation in the distal bowel of some IBS patients. These observations now prompt the question as to what maintains gut dysfunction in these patients. The intestinal microbiota influences a broad array of host organs that include the gut and the brain, and is an important determinant of normal function in these systems. Disruption of the delicate balance between the host and its intestinal microbiota (termed dysbiosis) res... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964896 Wed, 09 Sep 2009 00:00:00 +0100 2964896 http://www.medworm.com/index.php?rid=2964895&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002989%2Fabstract%3Frss%3Dyes Abstract: Gastrointestinal infection is ubiquitous worldwide though the pattern of infection varies widely. Poor hygiene and lack of piped water is associated with a high incidence of childhood infection, both viral and bacterial. However in developed countries bacterial infection is commoner in young adults. Studies of bacterial infections in developed countries suggest 75% of adults fully recover, however around 25% have long lasting changes in bowel habit and a smaller number develop the irritable bowel syndrome (IBS). Whether the incidence is similar in developing countries is unknown. Post-infective IBS (PI-IBS) shares many features with unselected IBS but by having a defined onset allows better definition of risk factors. These are in order of importance: severity of initial illness,... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964895 Tue, 01 Sep 2009 00:00:00 +0100 2964895 http://www.medworm.com/index.php?rid=3344281&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003259%2Fabstract%3Frss%3Dyes Non-invasive evaluation of recurrent hepatitis C in liver transplanted patients is an unmet clinical need. While protocol liver biopsy (LB) is still the standard of care, it could be potentially avoided in patients with mild/stable hepatitis, by monitoring routine blood chemistries combined with transient elastography (TE) . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344281 Wed, 26 Aug 2009 00:00:00 +0100 3344281 http://www.medworm.com/index.php?rid=3344278&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003041%2Fabstract%3Frss%3Dyes Sir, I read with great interest the Commentary by Kreek et al. regarding the treatment of chronic hepatitis C in recovering opiate addicts . In their Commentary, the authors detail the American and Italian perspectives in this field and state that the Belfiori et al. study is the first published Italian experience of treating chronic hepatitis C in the SerT setting. I would like to point out that, as cited by Belfiori et al., in 2007 we reported the efficacy of a multidisciplinary standardised management model for chronic hepatitis C in 53 drug addicts in the SerT setting in Italy . Although Belfiori and co-workers reported a slightly lower sustained virological response (50%) than we obtained (58.6%), their conclusions essentially confirm our data. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344278 Wed, 26 Aug 2009 00:00:00 +0100 3344278 http://www.medworm.com/index.php?rid=2964894&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003028%2Fabstract%3Frss%3Dyes Symptoms of the irritable bowel syndrome (IBS) occur in the absence of underlying structural or biochemical abnormalities within or outside the gut. Although widely accepted, this definition reflects uncertainty on the actual nature of the symptoms and does not satisfy patients. Nonetheless, the future is likely to be brighter since research in the field of IBS is fast moving and cellular, molecular and microbiological mechanisms are being identified and recognised as significant players in the complex pathophysiology of IBS. These recent steps forward in the understanding of IBS pathophysiology represent a unique opportunity to speed up the process of drug development and help manage one of the most common disorders of the humankind. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964894 Wed, 26 Aug 2009 00:00:00 +0100 2964894 http://www.medworm.com/index.php?rid=3344279&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003260%2Fabstract%3Frss%3Dyes The authors of the commentary published in the April 2009 issue of Digestive and Liver Disease by no means wish to diminish the relevance of the study by Guadagnino et al., who investigated treatment of chronic hepatitis C in former drug addicts receiving agonist or antagonist therapy in 6 Italian drug treatment centres during 2002–2003 . In their study population 56.6% of patients was infected by HCV genotype 3, and was treated with pegylated interferon alpha plus ribavirin for 24 weeks, while the remainder was infected with genotype 1 or 4, and was treated for 48 weeks, as per current guidelines. The overall rate of sustained virological response was similar to that reported in registration trials (58.6%), even though their genotype distribution was more favourable; however the reporte... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344279 Tue, 25 Aug 2009 00:00:00 +0100 3344279 http://www.medworm.com/index.php?rid=2779999&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002990%2Fabstract%3Frss%3Dyes The treatment of hepatocellular carcinoma (HCC) has witnessed major changes over the last 5 years. Until the early 2000s, HCC was a malignancy typically diagnosed at an advanced stage with a few therapeutic options: after the failure of a locoregional treatment there was no effective systemic therapy other than supportive care . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2779999 Mon, 24 Aug 2009 23:00:00 +0100 2779999 http://www.medworm.com/index.php?rid=3344280&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900293X%2Fabstract%3Frss%3Dyes Gastrointestinal metastases are rare because the gastrointestinal tract is seldom a metastatic site from other types of cancer. Among these, melanoma and breast cancer are the most common . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344280 Fri, 21 Aug 2009 00:00:00 +0100 3344280 http://www.medworm.com/index.php?rid=3268239&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002904%2Fabstract%3Frss%3Dyes Conclusions: In unselected outpatients referred for colonoscopy, a single measurement of faecal calprotectin is not sufficiently accurate to identify those with significant colorectal disease. However, a normal result can help rule out organic disease among patients with diarrhoea and those with abdominal pain and/or constipation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268239 Thu, 20 Aug 2009 00:00:00 +0100 3268239 http://www.medworm.com/index.php?rid=3268232&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003247%2Fabstract%3Frss%3Dyes Abstract: This review deals with the combined approach of endoscopic ultrasound and endobronchial ultrasound for lung cancer staging. The review provides an overview for the gastroenterologist who performs endosonography with regard to the current evidence supporting the use of endoscopic ultrasound and endobronchial ultrasound in clinical practice. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268232 Wed, 19 Aug 2009 00:00:00 +0100 3268232 http://www.medworm.com/index.php?rid=2873600&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900303X%2Fabstract%3Frss%3Dyes It is a great pleasure for us to introduce this series of six reviews on the Irritable Bowel Syndrome (IBS), an intriguing syndrome affecting millions of patients throughout the world and representing a major daily workload for general practitioners and specialists alike. The term mini symposium is definitely an understatement to indicate this collection of elegant, comprehensive, provocative state-of-the-art papers proposed by the major experts in the field to cover all the relevant aspects of IBS. Their efforts are certainly timely, since research has been speeding up in the recent past and it is difficult, even for those of us actively involved in this area of Gastroenterology, to keep track of the all the relevant results appearing in the literature. (Source: Digestive and Liver Diseas... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873600 Sun, 16 Aug 2009 23:00:00 +0100 2873600 http://www.medworm.com/index.php?rid=2686166&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003077%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2686166 Tue, 11 Aug 2009 10:30:30 +0100 2686166 http://www.medworm.com/index.php?rid=3116856&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002928%2Fabstract%3Frss%3Dyes This article focuses on the utility and recent advances of endoscopic ultrasound in the diagnostic evaluation pancreaticobiliary disorders and analyses the data of well established interventional procedures such as celiac plexus neurolysis and pseudocyst drainage. Moreover, the more innovative procedures, such endoscopic ultrasound-guided biliary and pancreatic ducts access and drainage and the experimental use of direct endoscopic ultrasound-guided therapy of both solid and cystic pancreatic lesions will also be reviewed. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116856 Mon, 10 Aug 2009 00:00:00 +0100 3116856 http://www.medworm.com/index.php?rid=3116855&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002941%2Fabstract%3Frss%3Dyes Conclusions: If generalized to the entire Cochrane Database of Systematic Reviews, these characteristics may largely explain why physicians undervalue the Cochrane reviews as a source of evidence for clinical decision-making. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116855 Mon, 10 Aug 2009 00:00:00 +0100 3116855 http://www.medworm.com/index.php?rid=2964897&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809003004%2Fabstract%3Frss%3Dyes Abstract: Irritable bowel syndrome is a functional gastrointestinal disorder affecting up to 3–15% of the general population in western countries. It is characterised by unexplained abdominal pain, discomfort, and bloating in association with altered bowel habits. The pathophysiology of irritable bowel syndrome is multifactorial involving disturbances of the brain–gut axis. The pathophysiology provides the rationale for pharmacotherapy: abnormal gastrointestinal motor functions, visceral hypersensitivity, psychosocial factors, autonomic dysfunction, and mucosal immune activation. Understanding the mechanisms, and their mediators or modulators including neurotransmitters and receptors have led to several therapeutic approaches including agents acting on the serotonin receptor or seroton... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964897 Mon, 10 Aug 2009 00:00:00 +0100 2964897 http://www.medworm.com/index.php?rid=2873603&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002977%2Fabstract%3Frss%3Dyes Abstract: The pathophysiology of IBS is complex and still incompletely known. Both central and peripheral factors are thought to contribute to the symptoms of IBS, including psychosocial factors, abnormal GI motility and secretion, and visceral hypersensitivity. In this review the involvement of peripheral factors in the pathophysiology in IBS is reviewed. Altered GI motility is commonly found in this patient group, even though a specific motor pattern has been hard to find. Colonic transit has been found to be of relevance for the bowel habit of the patient. Abnormal gas handling within the gut is also commonly seen, and seems to be one, but not the only factor responsive for bloating. There is also limited evidence supporting the presence of abnormal GI secretion in IBS, but its relevanc... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873603 Sun, 09 Aug 2009 23:00:00 +0100 2873603 http://www.medworm.com/index.php?rid=2873602&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002953%2Fabstract%3Frss%3Dyes Abstract: There is increasing evidence for a key role of psychological processes and their central nervous system substrates in functional gastrointestinal disorders, although the exact nature of the relationship remains only partially understood. However, progress in this key area of psychosomatic medicine is rapidly being made. In this review article, we will give an overview of recent advances in understanding the complex mechanisms by which psychological processes and functional gastrointestinal disorder symptoms reciprocally influence each other. Various lines of evidence from different branches of biomedical and psychological science will be discussed, particularly epidemiology, patho- and psychophysiology and functional brain imaging, focusing on the most recent and novel findings. ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873602 Sun, 09 Aug 2009 23:00:00 +0100 2873602 http://www.medworm.com/index.php?rid=2873601&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002965%2Fabstract%3Frss%3Dyes Abstract: Symptoms consistent with the irritable bowel syndrome are remarkably frequent around the world. Irritable bowel syndrome prevalence ranges from 2.1% to 22%, depending on criteria used. Women are more frequently affected than men, but the reasons remain obscure; irritable bowel syndrome occurs in all age groups but there appears to be a modest decline in prevalence with advancing age again for unknown reasons. The incidence of irritable bowel syndrome per year has been estimated at approximately 1.5% in community subjects; annually only 0.2% of population will be diagnosed with irritable bowel syndrome. The natural history of irritable bowel syndrome is characterized by symptomatic flare ups and by a high rate of transition to other functional gastrointestinal diseases over the lo... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873601 Sun, 09 Aug 2009 23:00:00 +0100 2873601 http://www.medworm.com/index.php?rid=3268238&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002898%2Fabstract%3Frss%3Dyes Conclusion: 18F-FDG PET/CT has a low sensitivity for detecting adenomas. However, because of the specificity and PPV of the technique for neoplastic colorectal lesions, the presence of a focal colorectal FDG uptake justifies the patient undergoing colonoscopy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268238 Thu, 30 Jul 2009 00:00:00 +0100 3268238 http://www.medworm.com/index.php?rid=3268237&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002862%2Fabstract%3Frss%3Dyes Conclusions: The IL-1β-511 mutation can be associated with complex disease behaviour in Italian Crohn's disease patients. The IL-1RN*2 mutation may play a role in Northern European people with inflammatory bowel disease. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268237 Thu, 30 Jul 2009 00:00:00 +0100 3268237 http://www.medworm.com/index.php?rid=3177300&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002783%2Fabstract%3Frss%3Dyes Abstract: Background & aims: In a group of children with suspected pulmonary aspiration, we aimed to describe the type and physical characteristics of gastro-oesophageal reflux (GOR) episodes, and to determine their correlation with the lipid-laden macrophage (LLM) content in bronchoalveolar lavage (BAL).Patients and methods: Twenty-one children with a diagnosis of bronchial asthma, recurrent lung consolidations and recurrent laryngotracheitis underwent 24-h multichannel intraluminal impedance and pH (MII-pH) monitoring, fibreoptic bronchoscopy and BAL. The following parameters were evaluated: total number of reflux episodes, number of acid reflux [AR; pH4], height of reflux episodes, LLM content and percentage of neutrophils in the BAL.Results: The number of NAR episodes and the number of... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177300 Thu, 30 Jul 2009 00:00:00 +0100 3177300 http://www.medworm.com/index.php?rid=2780000&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002825%2Fabstract%3Frss%3Dyes Gastroesophageal varices are present in approximately 50% of patients with cirrhosis and bleeding from these is the most common lethal complication of cirrhosis . Cirrhotic patients without varices can develop them at a rate of 8% per year, and the ones with small varices can develop large varices at a similar rate . Among these, variceal hemorrhage occurs at a yearly rate of 5–15%, with most important risk factors for bleeding being the size of varices, decompensated cirrhosis (Child B/C) and the endoscopic presence of red wale marks . The current guidelines by the American Association for the Study of Liver Diseases (AASLD) recommend combination of pharmacological therapy (somatostatin or its analogues octreotide and vapreotide; terlipressin) and endoscopic therapy (endoscopic variceal... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2780000 Wed, 29 Jul 2009 23:00:00 +0100 2780000 http://www.medworm.com/index.php?rid=3268244&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002801%2Fabstract%3Frss%3Dyes Abstract: Background: Hypocaeruloplasminaemia can lead to tissue iron storage in Wilson's disease and the possibility of iron overload in long-term overtreated patients should be considered. The HFE gene encodes a protein that is intimately involved in intestinal iron absorption.Aims: The aim of this study was to determine the prevalence of the HFE gene mutation, its role in iron metabolism of Wilson's disease patients and the interplay of therapy in copper and iron homeostasis.Methods: The records of 32 patients with Wilson's disease were reviewed for iron and copper indices, HFE gene mutations and liver biopsy.Results: Twenty-six patients were negative for HFE gene mutations and did not present significant alterations of iron metabolism. The HFE mutation was significantly associated with... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268244 Wed, 29 Jul 2009 00:00:00 +0100 3268244 http://www.medworm.com/index.php?rid=3177309&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002916%2Fabstract%3Frss%3Dyes We have read the interesting comments from Elli et al. in the letter regarding our article “Optical coherence tomography in pediatric patients: a feasible technique for diagnosing celiac disease in children with villous atrophy” . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177309 Wed, 29 Jul 2009 00:00:00 +0100 3177309 http://www.medworm.com/index.php?rid=3344274&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002552%2Fabstract%3Frss%3Dyes Conclusion: In H. pylori infected patients allergic to penicillin, the generally recommended first-line treatment with omeprazole, clarithromycin and metronidazole has low efficacy for curing the infection. On the other hand, a levofloxacin-containing regimen (together with omeprazole and clarithromycin) represents an encouraging second-line alternative in the presence of penicillin allergy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344274 Mon, 27 Jul 2009 00:00:00 +0100 3344274 http://www.medworm.com/index.php?rid=3268243&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002813%2Fabstract%3Frss%3Dyes Conclusions: The simplified criteria may be useless for the diagnosis of patients with atypical features, especially patients with histological acute hepatitis. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268243 Mon, 27 Jul 2009 00:00:00 +0100 3268243 http://www.medworm.com/index.php?rid=3116866&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002540%2Fabstract%3Frss%3Dyes Abstract: Background: Depending on underlying aetiopathogenetic factors human gallstones contain various amounts of cholesterol, non-cholesterol sterols and bile acids, which have remained unexplored in paediatric gallstone patients.Aims: To evaluate sterol and bile acids compositions of paediatric gallstones.Patients and methods: Study group included 21 consecutively cholecystectomised children. Gas–liquid chromatography was used to quantitate gallstone sterols and bile acids. Results were compared to adult gallstones (n=194).Results: Cholesterol stones (n=9) had higher proportions of cholestenol and lathosterol, but lower those of lanosterol and phytosterols than pigment stones (n=12) (p (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116866 Mon, 27 Jul 2009 00:00:00 +0100 3116866 http://www.medworm.com/index.php?rid=3177305&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002564%2Fabstract%3Frss%3Dyes Abstract: Background and aims: Drug-induced liver injury (DILI) is the most common cause of death from acute liver failure, and accounts for approximately 13% of cases of acute liver failure in the United States. The clinical presentation of DILI covers a wide spectrum, from asymptomatic liver test abnormalities to symptomatic acute liver disease, prolonged jaundice and disability, or overt acute or subacute liver failure. The aim of our study was to evaluate the number of DILI cases admitted to our Unit and to identify the drugs responsible. Thus, we reviewed all clinical records of patients with DILI admitted to our Unit from 1996 to 2006.Patients and methods: A database was constructed, reporting demographic, clinical features at onset, laboratory results, suspected drugs and follow-up.... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177305 Wed, 22 Jul 2009 00:00:00 +0100 3177305 http://www.medworm.com/index.php?rid=3268248&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002394%2Fabstract%3Frss%3Dyes Bactibilia refers to infection of the bile. The infection increases in the presence of gallstones or biliary obstruction. There are very few reports on the prevalence of biliary infection in south Indian patients with gallstone disease, where mixed/pigment gallstones continue to dominate. The present study aimed at identifying the spectrum of biliary infection in patients with gall stones undergoing elective cholecystectomy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268248 Thu, 16 Jul 2009 00:00:00 +0100 3268248 http://www.medworm.com/index.php?rid=2686170&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002527%2Fabstract%3Frss%3Dyes A constant epidemiologic characteristic of hepatocellular carcinoma (HCC) worldwide is its striking prevalence in males, with a male/female ratio averaging 2:1 to 7:1, the latter proportion being more often found in HBV-positive cases. The unbalanced relationship with gender is not limited to incidence, prognosis being better in females, both in terms of spontaneous survival or survival after resection. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2686170 Wed, 15 Jul 2009 23:00:00 +0100 2686170 http://www.medworm.com/index.php?rid=2964909&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900228X%2Fabstract%3Frss%3Dyes We read with interest the paper by Norman et al. reporting the presence of primary biliary cirrhosis (PBC)-specific autoantibodies in 8/52 (15%) cases with systemic sclerosis (SSc). Among them, seven were positive for antibodies against disease-specific mitochondrial antigens and one for the sp100 nuclear body antigen. Anti-mitochondrial antibody (AMA) testing was performed by a commercially available ELISA (INOVA Diagnostics) using as antigen a hybrid preparation designated as MIT3 because it contains the three major mitochondrial autoepitopes, namely the E2 subunits of the pyruvate dehydrogenase complex (PDC), branched chain oxo-acid dehydrogenase complex (BCOADC) and the oxoglutarate dehydrogenase complex (OGDC) . Antibody reactivity to sp100, the major target antigen of the multiple nu... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964909 Wed, 15 Jul 2009 00:00:00 +0100 2964909 http://www.medworm.com/index.php?rid=3177304&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002515%2Fabstract%3Frss%3Dyes This study compared the predictive accuracy of these models for acute decompensated hepatitis.Methods: We investigated the outcome of 182 patients with acute decompensated hepatitis.Results: Twenty (11%) patients died at 3 months. The MELD-Na and MELDNa both had significantly higher area under the receiver operating characteristic curve (AUC) in comparison to MELD (MELD-Na: 0.908, MELDNa: 0.895, MELD: 0.823, p=0.004 and 0.001, respectively). Among 96 patients without specific antiviral treatment, the MELD-Na and MELDNa consistently had significantly higher AUC than the MELD (MELD-Na: 0.901, MELDNa: 0.882, MELD: 0.810, p=0.008 and 0.004, respectively). Three independent indicators, pre-existing cirrhosis (odds ratio [OR]: 5.67, 95% confidence interval [CI]: 1.72–18.7), serum albumin (Sour... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177304 Mon, 13 Jul 2009 00:00:00 +0100 3177304 http://www.medworm.com/index.php?rid=3177302&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002503%2Fabstract%3Frss%3Dyes Abstract: Background: Submucosal lifting of lesions prior to endoscopic resection is crucial to reduce complications and improve the technical feasibility of the procedure.Aim: To compare a self-assembled hydro-jet system vs. standard needle injection for tissue elevation prior to endoscopic resection of colorectal lesions.Methods: Randomised study performed at a single tertiary care institution. Consecutive patients with colonoscopic diagnosis of sessile polyps or non-polypoid lesions >5mm or laterally spreading tumours. Outcome measures: successful elevation, time to proper elevation, completeness of excision, cautery damage, and general histological diagnostic quality (blinded pathologic assessment).Results: 79 patients were randomised to hydro-jet (40 patients, group A) and needle (39 ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177302 Mon, 13 Jul 2009 00:00:00 +0100 3177302 http://www.medworm.com/index.php?rid=2585887&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900259X%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2585887 Fri, 10 Jul 2009 10:59:09 +0100 2585887 http://www.medworm.com/index.php?rid=3268250&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002497%2Fabstract%3Frss%3Dyes Thrombocytopenia is a common finding in cirrhotic patients with chronic hepatitis C (CHC), being reported in as many as 76% , and usually being related to splenic sequestration of platelets and inadequate thrombopoietin synthesis by advanced liver disease, and less often to an extrahepatic manifestation of CHC. The current standard treatment of CHC is pegylated interferon (PEG-IFN) with ribavirin. PEG-IFN can also induce the adverse effect of thrombocytopenia, which has been found in 6% of CHC patients , and is largely ascribed to a direct inhibition of cytoplasmic maturation of megakaryocytes and platelet production and peripheral immune destruction. Treatment with PEG-IFN-α2a is associated with a higher risk of developing thrombocytopenia than with PEG-IFN-α2b . The median platelet cou... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268250 Fri, 10 Jul 2009 00:00:00 +0100 3268250 http://www.medworm.com/index.php?rid=3268246&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900245X%2Fabstract%3Frss%3Dyes Conclusions: Novel viscous or hypertonic solutions for submucosal injection, perform better than normal saline and equally well as sodium hyaluronate in porcine stomachs in vitro. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268246 Fri, 10 Jul 2009 00:00:00 +0100 3268246 http://www.medworm.com/index.php?rid=3177311&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002424%2Fabstract%3Frss%3Dyes We read with interest the paper on a multicenter survey of chronic pancreatitis in Italy by Frulloni et al. that appeared in the April 2009 issue of Digestive and Liver Disease . It is an interesting work that describes the clinical characteristics of this disease on a vast series of patients from various Italian centers. The authors, however, neglect to mention that a prior such study was done, by me and my coworkers in 1977 , and their findings should be discussed also in relation to our previous data . Our study of chronic pancreatitis in Italy , widely cited in the literature, also involved patients from cities throughout Italy, and reported the etiological, clinical and histopathological features of this disease in precise detail; it is also the only Italian paper describing chronic a... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177311 Wed, 08 Jul 2009 00:00:00 +0100 3177311 http://www.medworm.com/index.php?rid=2964910&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002461%2Fabstract%3Frss%3Dyes We thank Drs. Mytilinaiou and Bogdanos for their comments on our study . We understand and share their concern with the consequences of obtaining positive MIT3 test results for patients without apparent PBC. Of the 7 systemic sclerosis (SSc) patients with positive MIT3 results in our cohort, 3 had borderline positive values (25.6, 25.8, 26.7, pos≥25 units) and the remaining 4 had moderate (81.0, 84.1, 84.1 units) to strong reactivity (126.1 units). Examination of the moderate to strong positive MIT3 sera by IFA on HEp-2 substrates showed an AMA pattern of reactivity for the one strong MIT3 positive sera, weak AMA reactivity for 2 of the moderate MIT3 positive sera, and AMA-like (but not clearly AMA) reactivity for 1 moderate MIT3 specimen. Two of the borderline positive specimens showed ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964910 Wed, 08 Jul 2009 00:00:00 +0100 2964910 http://www.medworm.com/index.php?rid=2780001&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001121%2Fabstract%3Frss%3Dyes Conclusions: The route of conduit transposition did not affect the outcome. However, an individualized approach depending upon the operative findings, radicality of the procedure, and perceived need for postoperative adjuvant therapy may be useful. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2780001 Tue, 07 Jul 2009 23:00:00 +0100 2780001 http://www.medworm.com/index.php?rid=2780016&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002229%2Fabstract%3Frss%3Dyes The Publisher regrets that an error occurred in the spelling of the author's name “L. Bellis” in the original abstract on Page A59. The corrected name and complete abstract appears below:SURVIVIN-IGM IMMUNO COMPLEX: A NOVEL CANDIDATE BIOMARKER OF CIRRHOSIS TO MONITOR PATIENTS PROGRESSION TOWARDS HEPATOCELLULAR CARCINOMAC. Matteuccia,b, R. Sorrentinoa,b, G.M. Ettorrec, L. Bellisd, A. Antenuccie, L. Beneducef, R. Santoroc, G. Vennareccic, J. Zuinf, P. Pierimarchia, C. Puotid, G. Rasia (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2780016 Sun, 05 Jul 2009 23:00:00 +0100 2780016 http://www.medworm.com/index.php?rid=2686169&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002448%2Fabstract%3Frss%3Dyes Coeliac disease (CD) is a gluten-sensitive enteropathy occurring in genetically predisposed individuals and characterised by chronic inflammation of the small intestinal mucosa that gradually leads to villous atrophy. It typically results in malabsorption of most nutrients, but its clinical expression is highly variable . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2686169 Thu, 02 Jul 2009 23:00:00 +0100 2686169 http://www.medworm.com/index.php?rid=3268251&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002473%2Fabstract%3Frss%3Dyes With great interest we read the articles about the diagnostic use of CA19-9 as a screening marker for malignant disease in the May issue of the Journal. We were especially intrigued by the findings of elevated CA19-9 levels in a large cohort of asymptomatic patients . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268251 Thu, 02 Jul 2009 00:00:00 +0100 3268251 http://www.medworm.com/index.php?rid=3268249&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002485%2Fabstract%3Frss%3Dyes Portal hypertensive enteropathy (PHE) constitutes a therapeutic challenge in 5–11% of patients with portal hypertension (PH) and chronic active bleeding . However, recent advances in the physiopathology of intestinal microvascular disturbances in animal models of PH , allow us to speculate on whether a pharmacologically mediated regression of PHE lesions in humans is possible. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268249 Thu, 02 Jul 2009 00:00:00 +0100 3268249 http://www.medworm.com/index.php?rid=3177308&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002382%2Fabstract%3Frss%3Dyes We have read with great interest the article recently published by Masci et al. . The authors describe the use of Optical Coherence Tomography (OCT) technique in the diagnosis of celiac disease (CD) and conclude that OCT is helpful to diagnose CD and avoids duodenal biopsies. However, some questions arise from the study design and the presented data. First of all, it is not clear how CD diagnosis has been made; in fact, it seems that 11 patients without villous atrophy are classified as celiacs, but their Marsh-Oberhuber grading is not reported. Moreover, as Table 1 shows the correlation between OCT patterns and histology, it appears a result not a method. In Table 2 patients with OCT pattern 1 are 12 whereas in the text they are 10 confounding percentages and statistical analysis. Further... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177308 Thu, 02 Jul 2009 00:00:00 +0100 3177308 http://www.medworm.com/index.php?rid=3177298&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002400%2Fabstract%3Frss%3Dyes Conclusions: The capacity for H2S synthesis varies throughout the rodent gastrointestinal tract, as does the distribution and contribution of the two key enzymes. Investigation of additional enzymatic sources of H2S and the development of more selective inhibitors are suggested. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177298 Thu, 02 Jul 2009 00:00:00 +0100 3177298 http://www.medworm.com/index.php?rid=3116867&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002308%2Fabstract%3Frss%3Dyes We report two cases of extremely rare spinal cord injuries after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. The patients had sensory loss below the T9 or T10 dermatomes and paraparesis or paraplegia within 6–8h after transcatheter arterial chemoembolization. One patient sustained paraplegia until death 2 months after transcatheter arterial chemoembolization and the other patient recovered almost completely 2 months after transcatheter arterial chemoembolization. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116867 Tue, 23 Jun 2009 00:00:00 +0100 3116867 http://www.medworm.com/index.php?rid=3268240&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002291%2Fabstract%3Frss%3Dyes Conclusions: ABS as a novel haemostatic agent could have a potential benefit in controlling bleeding from GI tumours. Prospective controlled studies are needed to help establish its efficacy, and perhaps offer a comparison to conventional haemostatic interventions. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268240 Mon, 22 Jun 2009 00:00:00 +0100 3268240 http://www.medworm.com/index.php?rid=3177303&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002369%2Fabstract%3Frss%3Dyes Abstract: There is little information on the long-term effect of liver transplantation (LT) on cardiac autonomic dysfunction in cirrhotic patients. We compared cardiac autonomic function before and in the long-term after LT. In a transversal study, we investigated 30 cirrhotics awaiting LT, 15 clinically stable patients 2–6 years after LT and 27 healthy controls. Seven cirrhotic patients were studied before LT, and 6, 12 and 33 months after LT, in a prospective fashion. Cardiac autonomic function was measured by heart rate variability (HRV) analysis during 24-h electrocardiogram recording. In the transversal study, patients with cirrhosis as compared to healthy controls had significantly reduced standard deviation of normal-to-normal RR intervals (SDNN) (p (Source: Digestive and Liver Di... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177303 Mon, 22 Jun 2009 00:00:00 +0100 3177303 http://www.medworm.com/index.php?rid=2585889&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002436%2Fabstract%3Frss%3Dyes Inflammatory bowel disease (IBD) is a chronic relapsing and remitting digestive disorder that includes both Crohn's disease and ulcerative colitis. The underlying cause of IBD remains unclear but is thought to involve an inherent defect in the innate immune system, possibly a breach in epithelial barrier function, which disrupts the delicate homeostatic balance achieved between commensal bacteria residing in the gut and immunosurveillance mechanisms of the mucosal immune system. The result is an overly aggressive adaptive immune response against the commensal flora or other antigens that involves massive recruitment of leukocytes into the affected intestinal tissues, inflammation, and tissue damage. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2585889 Sun, 21 Jun 2009 23:00:00 +0100 2585889 http://www.medworm.com/index.php?rid=3177310&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002370%2Fabstract%3Frss%3Dyes We report the first case of Dieulafoy's lesion occurring in the upper esophagus. The lesion caused massive upper GI bleed, and was diagnosed and treated successfully by endoscopy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177310 Thu, 18 Jun 2009 00:00:00 +0100 3177310 http://www.medworm.com/index.php?rid=3116861&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002060%2Fabstract%3Frss%3Dyes Abstract: Objective: Shigella dysenteriae Type 1 dysentery is a major cause of morbidity and mortality in children from less developed and developing countries. The present study explores the hypothesis that lactobacilli protect the host cell during S. dysenteriae Type 1 infection and its mechanism of action.Methods: Caco-2 cells incubated for 1h with Lactobacillus rhamnosus or Lactobacillus acidophilus at the multiplicity of infection of 100, either alone or in combination followed by addition of Shigella at the same multiplicity of infection for 5h served as treatment groups. Cells incubated with Shigella without lactobacilli addition served as infected cells. At the end of experimental period, cells were processed suitably to enumerate adherent and internalized Shigella. Reverse transcr... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116861 Wed, 17 Jun 2009 00:00:00 +0100 3116861 http://www.medworm.com/index.php?rid=3116872&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002266%2Fabstract%3Frss%3Dyes Dysphagia in the elderly is a common clinical problem which may be caused by many benign or malignant disorders . Barium-contrast oesophagography can identify many anatomic causes of dysphagia, and especially extrinsic compression which may be due to a neighbouring mass or vascular aetiology . A massive thoracic aortic aneurysm, severe atherosclerosis of the thoracic aorta or elongation of the aorta may cause Dysphagia aortica which refers to compression of the oesophagus by the aorta . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116872 Wed, 10 Jun 2009 00:00:00 +0100 3116872 http://www.medworm.com/index.php?rid=3116869&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002278%2Fabstract%3Frss%3Dyes The clinical utility of percutaneous liver biopsy is well recognized as it can yield invaluable information regarding staging and grading of liver disease, efficacy of various therapies and can aid in the diagnosis of complicated cases. As complications from this procedure are often rare, 60% occurring within 2h and 96% within 24h, it is generally performed on an outpatient basis and thought to be safe . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116869 Wed, 10 Jun 2009 00:00:00 +0100 3116869 http://www.medworm.com/index.php?rid=3344275&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002230%2Fabstract%3Frss%3Dyes Conclusions: Predictive anatomical factors for potentially difficult endoscopic colonoscopy can be defined by CT colonography. Looping occurs frequently during routine colonoscopy but hindered caecal intubation in only one case. Short-term fluoroscopy is extremely helpful to guide straightening and ancillary manoeuvres and should be used selectively in patients with looping during conventional colonoscopy. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3344275 Mon, 08 Jun 2009 00:00:00 +0100 3344275 http://www.medworm.com/index.php?rid=3268241&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002242%2Fabstract%3Frss%3Dyes Conclusions: An intestinal permeability evaluation in patients with chronic liver diseases might clarify the significance of intestinal permeability in the pathophysiology of both the progression of liver damage, and the occurrence of complications that accompany liver cirrhosis. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3268241 Mon, 08 Jun 2009 00:00:00 +0100 3268241 http://www.medworm.com/index.php?rid=2779998&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002217%2Fabstract%3Frss%3Dyes In conclusion, several scoring systems have been described for organ allocation, but today, none is definitely able to overcome the limitations of the Child–Turcotte–Pugh and model for end-stage liver disease systems. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2779998 Sun, 07 Jun 2009 23:00:00 +0100 2779998 http://www.medworm.com/index.php?rid=2460096&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001789%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2460096 Sun, 07 Jun 2009 20:20:19 +0100 2460096 http://www.medworm.com/index.php?rid=3116862&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002175%2Fabstract%3Frss%3Dyes Conclusions: Melatonin and Trolox reduce oxidative stress induced by lipopolysaccharide and ameliorate the effect of lipopolysaccharide on duodenal contractility. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116862 Fri, 05 Jun 2009 00:00:00 +0100 3116862 http://www.medworm.com/index.php?rid=2964904&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002114%2Fabstract%3Frss%3Dyes Conclusion: Circulating endothelial progenitor cells are increased in patients with portal hypertension±hepatocellular carcinoma. The negative correlation of endothelial progenitor cells with hepatic venous pressure gradient suggests a protective role of endothelial progenitor cells in liver cirrhosis whilst vascular endothelial growth factor is associated with high hepatic venous pressure gradient. In contrast, increased endothelial progenitor cells in hepatocellular carcinoma rather reflect tumour specific endothelial progenitor cells mobilisation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964904 Fri, 05 Jun 2009 00:00:00 +0100 2964904 http://www.medworm.com/index.php?rid=3177301&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002102%2Fabstract%3Frss%3Dyes Conclusions: For inappropriate EGD, the very low likelihood of cancer argues against endoscopic referral, whereas the low specificity substantially reduces the predictive value of an appropriate indication for both cancer and relevant endoscopic findings. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177301 Thu, 04 Jun 2009 00:00:00 +0100 3177301 http://www.medworm.com/index.php?rid=3116865&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002205%2Fabstract%3Frss%3Dyes Conclusions: Tumours after liver transplantation are associated with lower long-term survival, confirming that cancer is a major cause of late mortality in liver transplantation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116865 Thu, 04 Jun 2009 00:00:00 +0100 3116865 http://www.medworm.com/index.php?rid=3116859&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002084%2Fabstract%3Frss%3Dyes Conclusion: Our study shows a heterogeneous expression of COX-2 and iNOS in colorectal cancer. The up-regulation of COX-2 at the IF parallels an increase in vessel density and VEGF/VEGFR-2 expression, thus supporting the hypothesis that the tumor periphery is the most aggressive portion of a colorectal tumor. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116859 Thu, 04 Jun 2009 00:00:00 +0100 3116859 http://www.medworm.com/index.php?rid=2686173&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006361%2Fabstract%3Frss%3Dyes Abstract: Background: Vitamin C in gastric juice and in vitro has been shown to inhibit the growth of Helicobacter pylori (H. pylori).Aims: The purpose of this study was to investigate the effect of addition of vitamin C to eradication regimen on H. pylori eradication rate.Patients: This randomised controlled clinical trial was conducted on 312 patients with H. pylori infection who had referred to the Taleghani Research Center of Gastroenterology and Liver Disease.Methods: Patients were randomly divided into two groups. Group A patients (162 patients) received amoxicillin 1g and metronidazole 500mg b.i.d., bismuth 240mg b.i.d. and omeprazole 40mg q.i.d. in two divided doses. Patients in group B (150 patients) received the same regimen plus 500mg vitamin C per day. All patients received the... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2686173 Tue, 02 Jun 2009 23:00:00 +0100 2686173 http://www.medworm.com/index.php?rid=2873604&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002187%2Fabstract%3Frss%3Dyes Abstract: Background and aim: Segmental colitis associated with diverticula (SCAD) has recently drawn a particular attention in the field of rare forms of colitis because of some peculiarities suggesting both its autonomy as a clinical entity and a resemblance with the most relevant forms of inflammatory bowel diseases (IBD). Aim of this review was to report the state of art on this topic.Methods: Epidemiological, clinical, endoscopic/histological and diagnostic features are described. Moreover, from both the pathogenetic and therapeutic point of view, new relevant information is highlighted regarding the possible role of tumour necrosis factor alpha (TNF-alpha) in mucosal inflammation.Results: SCAD would appear as a rare autonomous clinical entity distinctive of old age, although it is st... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873604 Mon, 01 Jun 2009 23:00:00 +0100 2873604 http://www.medworm.com/index.php?rid=2585890&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002254%2Fabstract%3Frss%3Dyes Gamma-glutamyltransferase (GGT) is an enzyme present in cell membranes of many tissues, especially those concerned in secretory or absorptive processes. Increased serum GGT has been regarded as a biomarker of hepato-biliary disease and of alcohol consumption, but its serum activity is affected by several factors such as drugs, age, sex, and body weight . People with high serum GGT levels have higher mortality from all causes, liver disease, cancer, and diabetes, partly because of the association between GGT and other risk factors, and partly because GGT is an independent predictor of risk . Recent population-based epidemiological studies have shown a strong association of serum GGT activity with obesity, physical inactivity, hypertension, dyslipidemia, and hyperinsulinemia. In subjects wit... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2585890 Thu, 28 May 2009 23:00:00 +0100 2585890 http://www.medworm.com/index.php?rid=2964903&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001753%2Fabstract%3Frss%3Dyes Conclusion: The regulatory data regarding kava hepatotoxicity is selective and of low quality, not supportive of the regulatory proposed causality; but instead, is an explanation of the overall causality discussions of kava hepatotoxicity. We are proposing that the regulatory agency reports data in full length and reevaluates causality. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964903 Thu, 28 May 2009 00:00:00 +0100 2964903 http://www.medworm.com/index.php?rid=3177297&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002059%2Fabstract%3Frss%3Dyes Abstract: Background: It is unclear whether questionnaires and diary cards, which are widely used to collect data on bowel habits, provide analogous information.Aims: We verified the concordance between the data provided by a daily diary and a retrospective questionnaire.Methods: A 4-week diary (DIARY) concerning bowel habits was compiled by 221 subjects. They were also asked to fill out a questionnaire on their bowel habits before (BEF) and after (AFT) the diary period.Results: Concerning bowel movements, no significant difference was detected in the concordance between BEF and DIARY (ρ: 0.80), AFT and DIARY (ρ: 0.84), or BEF and AFT (ρ: 0.84).The mean concordance in the other defecation-related parameters between BEF and DIARY (K: 0.62) and between DIARY and AFT (K: 0.63) were both si... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3177297 Wed, 27 May 2009 00:00:00 +0100 3177297 http://www.medworm.com/index.php?rid=3116870&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002199%2Fabstract%3Frss%3Dyes We have read with interest the papers of Kim et al. and Ventrucci et al. together with the editorial of Barugola et al. . We completely agree with the conclusions drawn by all the authors and we would add the experience of the Sant’Orsola-Malpighi Hospital (Bologna, Italy) on this topic. We have concluded the first phase of a project on pancreatic neoplasia named NeoPan collecting clinical data of patients with suspicion of pancreatic cancer in order to validate a diagnostic and therapeutic flow-chart for managing these patients according to a multidisciplinary approach. Serum CA 19-9 was determined in 72 cases (median: 71.5U/μL; interquartile range: 18–597U/μL) out of the 143 patients enrolled from March 2005 to May 2006. CA 19-9 was higher than the upper reference limit (37U/μL) i... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116870 Wed, 27 May 2009 00:00:00 +0100 3116870 http://www.medworm.com/index.php?rid=3116864&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002072%2Fabstract%3Frss%3Dyes Conclusions: In line with previous results, zone 3 necrosis is a histological characteristic of autoimmune hepatitis with acute presentation. Autoimmune hepatitis with acute presentation includes not only histological acute hepatitis but also acute exacerbation of pre-existing chronic disease. On the other hand, Japanese patients with acute presentation may also have different clinical features from Caucasian patients. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116864 Wed, 27 May 2009 00:00:00 +0100 3116864 http://www.medworm.com/index.php?rid=3116863&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001960%2Fabstract%3Frss%3Dyes Abstract: Background: The EPKi system (Pentax, Japan) enables resolution above HDTV. Aim of the study was to test the efficacy of HD+ alone and with the new post-processing digital filter i-Scan or chromoendoscopy (Methylene blue 0.1%) in screening for colorectal cancer. We focused on lesions less than 5mm as a surrogate marker for the optical possibilities of the EPKi system.Methods: The last 30cm of the colon in a screening population were inspected with HD+ alone, in combination with i-Scan (2:1 randomisation) and subsequently with chromoendoscopy.All lesions were characterized and targeted biopsies were performed.Results: i-Scan augmented in 69 patients the identification of lesions from 176 to 335 (p (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116863 Wed, 27 May 2009 00:00:00 +0100 3116863 http://www.medworm.com/index.php?rid=3116860&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001959%2Fabstract%3Frss%3Dyes Conclusions: Conventional histological examination as the golden standard in coeliac disease diagnosis is questionable. Serum and especially intestinal TG2-targeted autoantibodies seem promising in future coeliac disease diagnostics. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116860 Wed, 27 May 2009 00:00:00 +0100 3116860 http://www.medworm.com/index.php?rid=2964902&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002126%2Fabstract%3Frss%3Dyes Abstract: Objective: We tested whether gastro-oesophageal pressure gradient is augmented in sliding hiatal hernia and the yield of oesophageal manometry in diagnosing sliding hiatal hernia.Methods: Patients with equivalent body mass index were categorised according to manometry and endoscopy in groups: (1) no sliding hiatal hernia (n=147); (2) sliding hiatal hernia solely at endoscopy (n=46); and (3) sliding hiatal hernia at manometry (n=22). The yield of manometry was assessed taking endoscopy as referential.Results: Gastro-oesophageal pressure gradient was similar between groups both at inspiration (13.3±5.7mmHg vs. 13.6±5.4mmHg vs. 12.6±4.4mmHg; P=0.874) or expiration (5.1±3.8mmHg vs. 5.2±3.6mmHg vs. 5.1±3.7mmHg; P=0.767). Group 3 patients were older than those of groups 1 and 2 (... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964902 Wed, 27 May 2009 00:00:00 +0100 2964902 http://www.medworm.com/index.php?rid=2964900&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001972%2Fabstract%3Frss%3Dyes Conclusion: Gastric cancer exosomes promoted tumour cell proliferation, at least in part, by activation of PI3K/Akt and mitogen-activated protein kinase/extracellular-regulated protein kinase pathways. The decreased expression of Casitas B-lineage lymphoma proteins might have contributed to the activation of Akt and extracellular-regulated protein kinase. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964900 Wed, 27 May 2009 00:00:00 +0100 2964900 http://www.medworm.com/index.php?rid=3116871&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002096%2Fabstract%3Frss%3Dyes I read with interest the recent publication by Katsinelos et al. on examination of the laryngopharyngeal area during routine upper gastrointestinal (GI) endoscopy . Despite the overall low yield, they highlighted an important aspect of upper GI endoscopy examination that is commonly neglected. They also showed it can be done in most cases without causing additional discomfort to the patient. However, there is another area that deserves attention. The proximal portion of the esophagus, just beyond the upper esophageal sphincter is the other commonly neglected area. Abnormal or pathological findings are uncommon but may account for patients’ symptoms. Cervical inlet patch (CIP) is probably the most commonly encountered abnormality in this area with incidence ranging from 0.29 to 10% in end... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=3116871 Mon, 25 May 2009 00:00:00 +0100 3116871 http://www.medworm.com/index.php?rid=2964898&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001741%2Fabstract%3Frss%3Dyes Abstract: The fibrogenic evolution of chronic viral hepatitis B and C towards cirrhosis represents a key issue in clinical Hepatology whose monitoring still relies on liver biopsy and consequent histopathological staging. In the last decade, non-invasive methodologies have been proposed to predict the presence of fibrosis in chronic liver disease. Most of these methods are based on algorithms, including biochemical parameters, which have demonstrated an acceptable diagnostic accuracy towards the two extremities of the fibrogenetic process. The introduction of transient elastography has represented a further advancement in clinical Hepatology and it seems that the combination of different non-invasive methodologies will provide an improvement in the clinical management of disease progressio... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964898 Mon, 25 May 2009 00:00:00 +0100 2964898 http://www.medworm.com/index.php?rid=2873612&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001194%2Fabstract%3Frss%3Dyes Hepatitis B reactivation in lymphoma patients who are isolated anti-HBc carriers is a severe and potentially fatal complication of chemotherapy or chemo-immune therapy. Conventional chemotherapy for lymphoma has been documented to cause hepatitis B virus (HBV) related liver disease in HBsAg negative patients with occult HBV infection, but HBV reactivation has been increasingly reported after combined Rituximab (a monoclonal antibody against CD20) and multiagent chemotherapy for B-cell lymphomas. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873612 Sun, 24 May 2009 23:00:00 +0100 2873612 http://www.medworm.com/index.php?rid=2964901&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001522%2Fabstract%3Frss%3Dyes Conclusions: Our study shows that the recently recommended short-interval 1-year surveillance colonoscopy following colorectal cancer resection is a clinically efficient and cost-effective strategy in terms of cancer detection and cancer-specific death prevention. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964901 Fri, 22 May 2009 00:00:00 +0100 2964901 http://www.medworm.com/index.php?rid=2873608&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001480%2Fabstract%3Frss%3Dyes Abstract: Background: Cystic fibrosis is the most common lethal recessive disorder among Caucasians. Over 1500 mutations have been identified in cystic fibrosis transmembrane conductance regulator disease-gene so far. A large variability of the clinical phenotype has been observed both in cystic fibrosis patients bearing the same genotype, and in affected sibpairs. Thus, genes inherited independently from cystic fibrosis transmembrane conductance regulator could modulate the clinical expression of cystic fibrosis.Methods: We analysed some putative modifier genes of liver cystic fibrosis phenotype (serpin 1, hemochromatosis, transferrin receptor 2, ferroportin 1, mannose binding lectin and adenosine triphospate-binding cassette subfamily B member 4) in 108 unrelated cystic fibrosis patients... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873608 Wed, 20 May 2009 23:00:00 +0100 2873608 http://www.medworm.com/index.php?rid=2873607&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001509%2Fabstract%3Frss%3Dyes Conclusion: These data suggest that ancillary manoeuvres are used frequently but are not necessarily predictive of successful caecal intubation. Additional data from prospective, randomised studies are needed to address the overall utility and optimal application of individual manoeuvres. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873607 Wed, 20 May 2009 23:00:00 +0100 2873607 http://www.medworm.com/index.php?rid=2490029&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809002047%2Fabstract%3Frss%3Dyes In 1992 “Le Lymphome Imaginaire” satirized the emerging fascination with gastric lymphomas . For a brief time, inspired by Isaacson's brilliant discovery of a direct connection between Helicobacter pylori and B-cell lymphomas of the mucosa-associated lymphoid tissue , monoclonality became the equivalent of Argan's imaginary symptoms. Countless MALT lymphomas were diagnosed and promptly cured by molecular cowboys who found clones in the most innocent of lymphoid follicles and shot them dead with triple therapies. Texas metaphors entered the therapeutic parlance – the only good Helicobacter is a dead one – and a sense of omnipotence pervaded the humblest practitioner who, armed with two antibiotics and an acid suppressant could now succeed where oncologists had failed. Hopes to conqu... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2490029 Thu, 14 May 2009 23:00:00 +0100 2490029 http://www.medworm.com/index.php?rid=2585904&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001443%2Fabstract%3Frss%3Dyes The author regrets that an error occurred in the spelling of the second author's name, W. Van Laer. The correction is made to the authors’ listing above. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2585904 Wed, 13 May 2009 23:00:00 +0100 2585904 http://www.medworm.com/index.php?rid=2873606&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001200%2Fabstract%3Frss%3Dyes Conclusion: The use of sedation and physiologic monitoring in Greece is now standard practice during endoscopy. Benzodiazepines, either alone or combined with an opioid, are used by the majority of endoscopists, while propofol is used in selected cases, mainly in the presence of an anaesthesiologist. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873606 Sun, 03 May 2009 23:00:00 +0100 2873606 http://www.medworm.com/index.php?rid=2780003&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001492%2Fabstract%3Frss%3Dyes Abstract: Background: In secondary care, irritable bowel syndrome (IBS) is frequently associated with non-colonic symptoms including lethargy, backache and chest pains which can result in inappropriate referral to different specialities with the condition remaining unrecognised. This could also be a problem in the elderly where comorbidity is common, especially as irritable bowel syndrome is usually associated with a younger age group.Methods: A survey of 230 consecutive patients (aged 65–94) attending an elderly care clinic examining referral patterns, irritable bowel syndrome symptoms, duration of disease, non-colonic symptomatology and previous investigation.Results: 211 of 230 (92%) patients completed the questionnaire with 46 (22%) having symptoms suggestive of irritable bowel syndr... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2780003 Sun, 03 May 2009 23:00:00 +0100 2780003 http://www.medworm.com/index.php?rid=2490030&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900173X%2Fabstract%3Frss%3Dyes In recent years, the developments in the treatment of chronic hepatitis C afforded a dramatic increase in its efficacy. The registration of pegylated interferons (Peg-IFN) and ribavirin following large registrative trials has been followed by a number of studies aimed at optimising doses and duration. As a result, a sustained virological response (SVR) can be achieved in >50% of the patients with genotype 1 and >80% of those with genotype 2–3 . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2490030 Sun, 03 May 2009 23:00:00 +0100 2490030 http://www.medworm.com/index.php?rid=2384023&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006701%2Fabstract%3Frss%3Dyes Format: Hardcover book. Purpose: To offer comprehensive, up-to-date coverage of the use of endoscopy in the prevention, diagnosis and management of cancer. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384023 Sun, 03 May 2009 20:47:33 +0100 2384023 http://www.medworm.com/index.php?rid=2384022&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006993%2Fabstract%3Frss%3Dyes Villous adenomas of the appendix are uncommon and rarely diagnosed during routine colonoscopy. Less than 60 cases of appendiceal villous adenomas are described worldwide and a reported frequency of 0.06% in appendectomy specimens. There are no specific symptoms for these neoplasms and clinical presentation is often acute appendicitis. The malignant potential of appendiceal adenomas is not well documented but has been assumed to be the same to those in other parts of the colon and rectum. Malignant in situ changes are reported in 63% cases . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384022 Sun, 03 May 2009 20:47:32 +0100 2384022 http://www.medworm.com/index.php?rid=2384021&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006956%2Fabstract%3Frss%3Dyes I read with interest the paper about a case of severe hemolytic anemia and fatal hepatic failure associated with prolonged nimesulide use , considering that apparently only one case of this association has previously published . In fact, spontaneous reports of adverse drug events are helpful warning signals of rare toxicities. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384021 Sun, 03 May 2009 20:47:32 +0100 2384021 http://www.medworm.com/index.php?rid=2384020&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865807006718%2Fabstract%3Frss%3Dyes Abstract: The association between gastric carcinoma and lymphoma is rare. Confocal laser endomicroscopy is a new diagnostic tool that allows the identification of cellular and vascular architecture during endoscopy. This is the first report of an in vivo early gastric carcinoma diagnosis by confocal laser endomicroscopy in a patient successfully treated for a primary gastric diffuse large-B-cell lymphoma. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384020 Sun, 03 May 2009 20:47:31 +0100 2384020 http://www.medworm.com/index.php?rid=2384019&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808004337%2Fabstract%3Frss%3Dyes An 81-year-old presented with a 5-day history of increasing abdominal pain, distension, and vomiting. Her bowels were not active for 2 days, but she was passing flatus. Laboratory examination showed a haemoglobin of 9.7g/dL (≤14g/dL), haematocrit of 29.7% (≥41%), leucocytes of 13.6/nl (≤10.0/nl), creatinine of 3.7mg/dL (≤1.1mg/dL). (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384019 Sun, 03 May 2009 20:47:30 +0100 2384019 http://www.medworm.com/index.php?rid=2384018&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808002569%2Fabstract%3Frss%3Dyes Conclusions: Short-term nasobiliary drainage should be considered in patients with cholestatic acute viral hepatitis with intractable pruritus and cough for symptomatic relief. It may help in faster recovery in these patients. However, a larger randomized controlled study is warranted. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384018 Sun, 03 May 2009 20:47:26 +0100 2384018 http://www.medworm.com/index.php?rid=2384017&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808007044%2Fabstract%3Frss%3Dyes Conclusion: The CLIP system provided the best prognostic stratification in the present cohort of HCC patients who were mainly at late stages. However, early detection of HCCs has become more common in Taiwan in recent years, which has led to the predominance of early-stage HCC patients. Therefore, modified TNM-based JIS combined AFP may now be the most applicable system in recent years. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384017 Sun, 03 May 2009 20:47:23 +0100 2384017 http://www.medworm.com/index.php?rid=2384016&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006646%2Fabstract%3Frss%3Dyes Conclusions: Our data fail to demonstrate the influence of IL-10 promoter gene polymorphisms on the response to combination therapy in Taiwanese chronic hepatitis C patients. The impact of genetic variations in IL-10 haplotype on the response to anti-HCV treatment among different ethnic populations deserves further examination. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384016 Sun, 03 May 2009 20:47:01 +0100 2384016 http://www.medworm.com/index.php?rid=2384015&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006713%2Fabstract%3Frss%3Dyes Abstract: Background: The pro-inflammatory cytokine IL-18 and its activator Caspase-1 are involved in acute liver failure and acute-on-chronic-liver-failure. In acute liver failure and acute-on-chronic-liver-failure, the MARS system has been used to support liver function. Enhancement of IL-18, as seen in other extracorporeal-support systems like hemodialysis might thus have mitigated beneficial effects of the MARS system in acute hepatic failure.Patients and methods: We measured serum concentrations of IL-18 and Caspase-1 in 10 patients with acute liver failure and 10 patients suffering from acute-on-chronic-liver-failure, who were all treated with MARS. Thirteen patients suffering from chronic hepatic failure and 15 healthy individuals served as controls. Data are given as mean with 95% ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384015 Sun, 03 May 2009 20:46:57 +0100 2384015 http://www.medworm.com/index.php?rid=2384014&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006919%2Fabstract%3Frss%3Dyes Abstract: Background: Although partial splenic embolization (PSE) has been widely used for treatment of leucocytopaenia and thrombocytopaenia in cirrhosis, only few studies on the correlation between splenic infarction rate and long-term outcome of partial splenic embolization have been reported so far.Aim: To evaluate long-term results of partial splenic embolization with different infarction rates in cirrhotic patients with hypersplenism.Methods: Sixty-two consecutive patients with hypersplenism in cirrhosis received partial splenic embolization. According to the splenic infarction rate after partial splenic embolization, the patients were divided into three groups: more than 70% in group A (n=12), 50–70% in group B (n=34), and less than 50% in group C (n=16). The post-partial splenic ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384014 Sun, 03 May 2009 20:46:53 +0100 2384014 http://www.medworm.com/index.php?rid=2384013&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006312%2Fabstract%3Frss%3Dyes Conclusions: The OTSC system is a new endoscopic tool for compression of large tissue areas and its indications are nonvaricose bleedings difficult to control and lesions or perforations of the GI tract. The initial clinical use of this clipping device proved to be efficient and effective. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384013 Sun, 03 May 2009 20:46:51 +0100 2384013 http://www.medworm.com/index.php?rid=2384012&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006907%2Fabstract%3Frss%3Dyes Conclusions: Esomeprazole counteracts the detrimental action of indomethacin on ulcer repair through both acid-dependent and acid-independent effects. The acid-independent actions are related to decrease in tissue oxidation and apoptosis and to enhancement of nuclear factor-kB activation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384012 Sun, 03 May 2009 20:46:47 +0100 2384012 http://www.medworm.com/index.php?rid=2384011&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580800635X%2Fabstract%3Frss%3Dyes Conclusion: This study has confirmed this half-ED therapy is beneficial for patients with Crohn’s disease. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384011 Sun, 03 May 2009 20:46:45 +0100 2384011 http://www.medworm.com/index.php?rid=2384010&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808006300%2Fabstract%3Frss%3Dyes Conclusion: Our data show a significant effect of the CTLA4 CT60G allele at the homozygous state on the risk of developing AITD in children with CD and suggest that the reported association of the CTLA4 CT60 A/G polymorphism with CD is limited to the subgroup of patients who are or will be complicated with AITD. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384010 Sun, 03 May 2009 20:46:41 +0100 2384010 http://www.medworm.com/index.php?rid=2384009&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001182%2Fabstract%3Frss%3Dyes A suitable prognostic assessment is of paramount importance for the correct management of any progressive and eventually lethal disease. In fact, an outcome prediction, based on the presenting features of the disease, allows physicians: (1) to assess, in phase I and phase II studies, if a treatment can improve the expected natural course of the illness (when no established treatment is currently available) or if the tested intervention promises to be better than the usual treatment (when the prognostication also takes into account the effect of established treatments); (2) to allocate patients with an equivalent baseline prognosis to each group of phase III clinical trials; (3) last but not least, to provide correct information to patients and relatives at the time of diagnosis and treatme... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384009 Sun, 03 May 2009 20:46:39 +0100 2384009 http://www.medworm.com/index.php?rid=2384008&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865808007020%2Fabstract%3Frss%3Dyes Abstract: Hyperbilirubinemia is a common laboratory finding in clinical practice, being found in several haematological and liver diseases as well as in familial conditions (5–10% in Western countries). Although most of the familial forms of hyperbilirubinemia are classically viewed as benign conditions, they have gained an increased interest in the last few years since recent data have indicated that subjects with an impaired bilirubin metabolism may have an increased susceptibility to drug toxicity. The authors briefly review the main steps of bilirubin metabolism, with a special emphasis on the emerging concepts on the molecular mechanisms of regulation by nuclear receptors (NRs) and genetic factors. Then the different forms of isolated hyperbilirubinemia occurring in both adults and ... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384008 Sun, 03 May 2009 20:46:36 +0100 2384008 http://www.medworm.com/index.php?rid=2384007&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001558%2Fabstract%3Frss%3Dyes (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2384007 Sun, 03 May 2009 20:46:36 +0100 2384007 http://www.medworm.com/index.php?rid=2964908&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001431%2Fabstract%3Frss%3Dyes A 69-year-old male with diverticulosis presented to our ER in hemodynamically stable condition with a 2-day history of malaise, epigastric pain, and fever (39.6°C). Physical exam revealed a moderately distended abdomen with mildly tender hepatomegaly. Leukocytosis (16,400μl−1) with 21% bands, and elevated liver function tests (total bilirubin, 2.2mg/dl; aspartate transaminase, 124IU/l; alanine transaminase, 242IU/l) and serum lipase (283U/l) were noted on lab tests. The patient was immediately started on broad-spectrum antibiotics empirically. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964908 Thu, 30 Apr 2009 00:00:00 +0100 2964908 http://www.medworm.com/index.php?rid=2964905&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001455%2Fabstract%3Frss%3Dyes Abstract: Background: Type 1 sphincter of Oddi dysfunction is a clinical entity characterised by biliary-type pain, elevated liver biochemical tests, and common bile duct dilation. Sphincter fibrosis is a common finding in this type of dysfunction and may require in some cases a differential diagnosis with a malignant intra-papillary disease. Optical coherence tomography permits high-resolution, real-time imaging of the sphincter of Oddi microstructure by a probe inserted into the common bile duct through an ERCP catheter. No data exist on the evaluation of sphincter of Oddi fibrosis by optical coherence tomography during ERCP in vivo.Objective: To assess the feasibility of optical coherence tomography investigation of the sphincter of Oddi structure and assess its potential for diagnosing... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964905 Wed, 29 Apr 2009 00:00:00 +0100 2964905 http://www.medworm.com/index.php?rid=2964899&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001479%2Fabstract%3Frss%3Dyes Conclusions: Our data indicate that over-activated Notch-1 significantly protects BGC-823 cells from TNFα-induced apoptosis, and this effect is mediated, at least in part, by decreasing activation of caspase-3 independent of NF-κB. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2964899 Wed, 29 Apr 2009 00:00:00 +0100 2964899 http://www.medworm.com/index.php?rid=2873609&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001418%2Fabstract%3Frss%3Dyes Abstract: Background: Environmental and genetic factors play a role in the pathogenesis and natural history of non-alcoholic fatty liver disease (NAFLD).Methods: In 114 subjects with NAFLD we report the prevalence and correlation with clinical parameters of three polymorphisms: interleukin-6 (−174G/C), plasma cell differentiation antigen (K121Q) and microsomal transfer protein (−493G/T).In 59 biopsied patients with NAFLD the polymorphisms were also related to histological features.Results: IL-6 −174C variant was more prevalent (p (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2873609 Tue, 28 Apr 2009 23:00:00 +0100 2873609 http://www.medworm.com/index.php?rid=2780006&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001467%2Fabstract%3Frss%3Dyes Abstract: Background and aims: Although cyclosporin A has been reported to be effective in the treatment of severe ulcerative colitis, factors predicting its therapeutic efficacy remain unclear. Technical progress in endoscopic ultrasonography has improved visualisation of the structure of the colon wall. Here, to assess the value of endoscopic ultrasonography in predicting the response to cyclosporin A treatment, we evaluated the therapeutic effect of cyclosporin A by determining the pre- and post-cyclosporin A thickness of the mucosal layer in the rectum using endoscopic ultrasonography with an ultrasonic catheter probe.Patients and methods: Fifteen ulcerative colitis patients who did not respond to high-doses of corticosteroids were treated with cyclosporin A by continuous intravenous i... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2780006 Tue, 28 Apr 2009 23:00:00 +0100 2780006 http://www.medworm.com/index.php?rid=2686183&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900142X%2Fabstract%3Frss%3Dyes More than 40 years ago, the hydrogen breath test (H2 BT) was proposed as a simple test to diagnose lactose malabsorption and some methodological aspects are still debated. One important point is carbohydrate load: while a 50g dose, the amount of lactose in 1l of milk, seems excessive, there is agreement that a 20–25g dose, or even less , is a more physiological load. Nevertheless, in commenting on our results, Schirru et al. raise an objection diametrically opposite this trend: an increased load induces a better agreement between H2 BT and the genetic test. However, an even more important aspect is solution concentration and the induction of an osmotic effect and accelerated transit. Our group previously showed that administration of several sorbitol solutions at increasing concentration... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2686183 Tue, 28 Apr 2009 23:00:00 +0100 2686183 http://www.medworm.com/index.php?rid=2490028&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809001510%2Fabstract%3Frss%3Dyes Abstract: Hepatic progenitor cells are bi-potential stem cells residing in human and animal livers that are able to differentiate towards the hepatocytic and the cholangiocytic lineages. In adult livers, hepatic progenitor cells are quiescent stem cells with a low proliferating rate, representing a reserve compartment that is activated only when the mature epithelial cells of the liver are continuously damaged or inhibited in their replication, or in cases of severe cell loss.Hepatic progenitor cell activation has been described in various acute and chronic liver diseases. Their niche is composed by numerous cells such as Hepatic Stellate Cells, endothelial cells, hepatocytes, cholangiocytes, Kupffer cells, pit cells and inflammatory cells. All these cells, numerous hormones and growth fac... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2490028 Tue, 28 Apr 2009 23:00:00 +0100 2490028 http://www.medworm.com/index.php?rid=2780002&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900111X%2Fabstract%3Frss%3Dyes Conclusion: The 4G variant of the PAI-I gene may predispose to miscarriage a subset of celiac women; these data should be verified on larger populations. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2780002 Wed, 22 Apr 2009 23:00:00 +0100 2780002 http://www.medworm.com/index.php?rid=2686172&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000425%2Fabstract%3Frss%3Dyes Conclusion: Optical coherence tomography could be a helpful diagnostic tool in children with mild or marked villous atrophy for diagnosing celiac disease during upper gastrointestinal (GI) endoscopy, avoiding biopsies. However, duodenal biopsies are mandatory if the optical coherence tomography shows normal villous morphology in patients with positive antibodies. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2686172 Tue, 21 Apr 2009 23:00:00 +0100 2686172 http://www.medworm.com/index.php?rid=2350635&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000887%2Fabstract%3Frss%3Dyes Background and aims. Hypoxia, very common in malignant solid tumours, can induce epithelial-to-mesenchymal transition (EMT) in human cancer cells. Poorly invasive HepG2 cells have been experimentally manipulated to investigate relationships between moderate hypoxia, EMT, invasiveness and expression of Serpin-B3 (formerly known as Squamous Cell Carcinoma Antigen), a serin protease inhibitor able to induce apoptosis resistance and involved in EMT and cell proliferation. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350635 Tue, 21 Apr 2009 08:49:00 +0100 2350635 http://www.medworm.com/index.php?rid=2350634&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000875%2Fabstract%3Frss%3Dyes Background. The sodium/iodide symporter (NIS or SLC5A5) is a membrane glycoprotein that mediates active iodide uptake into normal thyroid follicular cells. A functional NIS is also overexpressed in breast cancers, in lactating mammary glands and fibroadenomas, in bile duct cells and in 50% of human cholangiocarcinomas (CCA). In other tissues and cancers, including normal and neoplastic keratynocytes, some CCAs and 10% of hepatocellular carcinomas (HCCs), NIS accumulates in the cytoplasm and does not transport iodide. In a rat liver cancer models NIS expression was closely associated with early steps of liver carcinogenesis. The function of cytoplasmic NIS and its role in cell transformation is, however, not known. NIS expression is controlled at the transcriptional level by both thyroid sp... Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350634 Tue, 21 Apr 2009 08:48:59 +0100 2350634 http://www.medworm.com/index.php?rid=2350633&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000863%2Fabstract%3Frss%3Dyes Background. Expression of the p53-paralog DNp73 oncogene increases progressively in chronic hepatitis, cirrhosis and HCC and greatly contributes to the chemoresistant phenotype of HCC cells. DNp73 isoforms do not activate transcription and do not induce apoptosis but act as dominant negative inhibitors of both p53 and TAp73. DNp73s are expressed from the intragenic P2p73 promoter and we have recently shown that its activity is positively regulated in hepatocytes by beta-catenin and p65/NFkB. In silico analisys of the P2p73 promoter indicates that it contains two conserved ISRE elements. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350633 Tue, 21 Apr 2009 08:48:59 +0100 2350633 http://www.medworm.com/index.php?rid=2350632&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000851%2Fabstract%3Frss%3Dyes Background. The strategy of therapy for primary liver cancer (HCC) is based on both functional and morfological classification, and is an open field of research. Recently the ability of MELD-Na score has been proposed as useful index for prediction the probability of survival in HCC. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350632 Tue, 21 Apr 2009 08:48:59 +0100 2350632 http://www.medworm.com/index.php?rid=2350631&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS159086580900084X%2Fabstract%3Frss%3Dyes Background. The characteristic of the lymphocitic infiltrate has been shown to be predictive of the outcome in patients with hepatocellular carcinoma (HCC). Aim. The main objective was to test the prognostic predictive value of phenotypic characteristics of circulating lymphocytes and mRNA expression of T-cell related molecules within resected tumor and non-tumor tissue from patients with HCC. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350631 Tue, 21 Apr 2009 08:48:58 +0100 2350631 http://www.medworm.com/index.php?rid=2350630&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000838%2Fabstract%3Frss%3Dyes Background. The decision process allocating a specific organ from a cadaveric or a living donor to a particular liver transplantation (LT) recipient is strongly influenced by ethical issues. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350630 Tue, 21 Apr 2009 08:48:58 +0100 2350630 http://www.medworm.com/index.php?rid=2350629&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000826%2Fabstract%3Frss%3Dyes Introduction. Liver transplantation (LT) is considered the optimal treatment for hepatocellular carcinoma (HCC). Since LT based on the Milan criteria (MC) has been shown to provide good disease-free survival, to excellent long-term survival and a low incidence of recurrence. We have analyzed individual tumor characteristics applying the new score “up-to-seven criteria” . (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350629 Tue, 21 Apr 2009 08:48:56 +0100 2350629 http://www.medworm.com/index.php?rid=2350628&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000814%2Fabstract%3Frss%3Dyes Background/Aims. In patients with a large hepatocellular carcinoma (LHCC: tumor diameter larger than 3cm), surgical treatment is the only potentially radical surgery. Tumor grade is the main predictor of post-surgical HCC recurrence, but preoperative biopsy has shown a poor diagnostic sensibility, especially in patients with LHCC. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350628 Tue, 21 Apr 2009 08:48:56 +0100 2350628 http://www.medworm.com/index.php?rid=2350627&cid=s_35515_17_f&fid=35515&url=http%3A%2F%2Fwww.dldjournalonline.com%2Farticle%2FPIIS1590865809000802%2Fabstract%3Frss%3Dyes Background and AIm. The assessment of serum levels of SCCA-IgM or AFP-IgM immune complexes may improve diagnosis of HCC and may also predict the progression of cirrhosis to HCC. Simulation studies on multiple diagnostic assays of cancer biomarkers suggest to combine biomarkers by linear logistic regression in order to optimize diagnostic accuracy. Aim of the study was to evaluate the diagnostic accuracy improvement in HCC by SCCA-IgM and AFP-IgM combination in sera of HCC and cirrhotic patients. (Source: Digestive and Liver Disease) Digestive and Liver Disease journals http://www.medworm.com/rss/comments.php?id=2350627 Tue, 21 Apr 2009 08:48:55 +0100 2350627