MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Early Human Development' source. Thu, 09 Feb 2012 17:49:15 +0100 http://www.medworm.com/index.php?rid=5542270&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002325%2Fabstract%3Frss%3Dyes Conclusions: In this study population, there was a high prevalence of BD in patients with permanent CH. Thyroid agenesis was the main etiological cause of CH in patients with associated congenital malformations. The high prevalence of CH+BD underlines the need for a comprehensive clinical diagnostic approach of the patients with CH. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542270 Mon, 26 Dec 2011 10:48:08 +0100 5542270 http://www.medworm.com/index.php?rid=5542269&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002192%2Fabstract%3Frss%3Dyes Conclusions: A preterm infant formula with an addition of probiotics leads to a rapid growth of LGG in the gut of bottle fed infants, but does not decrease the amount of pathogenic organisms, nor increase weight gain during enteral feeding, or decrease length of hospital stay. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542269 Mon, 26 Dec 2011 10:48:08 +0100 5542269 http://www.medworm.com/index.php?rid=5542268&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002180%2Fabstract%3Frss%3Dyes Conclusions: This study demonstrates that the 75th percentile of our TcB nomogram is able to exclude any subsequent severe hyperbilirubinaemia from 48h of life ahead. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542268 Mon, 26 Dec 2011 10:48:08 +0100 5542268 http://www.medworm.com/index.php?rid=5542267&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002179%2Fabstract%3Frss%3Dyes Conclusion: Parenting stress in mothers of preterm infants during early infancy does not appear to be greater than that in mothers of infants born at term. For both groups of mothers, depression symptoms, marital satisfaction and infant temperament were independent risk factors for high levels of parenting stress. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542267 Mon, 26 Dec 2011 10:48:08 +0100 5542267 http://www.medworm.com/index.php?rid=5542266&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002167%2Fabstract%3Frss%3Dyes Abstract: Background: It continues to be a challenge for clinicians to identify preterm infants likely to experience subsequent neurodevelopmental deficits. The Test of Infant Motor Performance (TIMP) and the assessment of spontaneous general movements (GMs) are the only reliable diagnostic and predictive tools for the functionality of the developing nervous system, if applied before term.Aim: To determine to what extent singular preterm assessments of motor performance can predict the neurodevelopmental outcome in 14-month olds.Methods: Thirty-seven preterm infants born (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542266 Mon, 26 Dec 2011 10:48:08 +0100 5542266 http://www.medworm.com/index.php?rid=5542265&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002155%2Fabstract%3Frss%3Dyes Abstract: Background: Neonatal seizures may persist despite treatment with multiple anti-epileptic drugs (AEDs).Objective: To determine in term-born infants with seizures that required two or more AEDs, whether treatment efficacy and/or the underlying disorder were related to neurological outcome.Design/methods: We included 82 children (born 1998–2006) treated for neonatal seizures. We recorded mortality, aetiology of seizures, the number of AEDs required, achievement of seizure control, and amplitude-integrated-EEG (aEEG) background patterns. Follow-up consisted of an age-adequate neurological examination. Surviving children were classified as normal, having mild neurological abnormalities, or cerebral palsy (CP).Results: Forty-seven infants (57%) had status epilepticus. The number of A... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542265 Mon, 26 Dec 2011 10:48:08 +0100 5542265 http://www.medworm.com/index.php?rid=5542264&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002143%2Fabstract%3Frss%3Dyes Conclusion: We found early-onset sepsis and episodes of hypocarbia within the first days of life being independently associated with PVL.Highlights: ► Besides preterm premature rupture of the membranes and chorioamnionitis early-onset sepsis remains an additional risk factor fort he development of cystic PVL. ► The association between hypocarbia and PVL is stringent. However, the individual risk assessment is difficult in clinical routine. ► Neurodevelopmental follow-up of infants with cystic PVL reveals adverse neurological outcome in the majority of infants. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542264 Mon, 26 Dec 2011 10:48:08 +0100 5542264 http://www.medworm.com/index.php?rid=5542263&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002131%2Fabstract%3Frss%3Dyes Abstract: Background: To assess pain or stress in newborn infants submitted to intensive care is important but difficult, as different observational pain scales are not always reliable in premature infants. As an indicator of pain, skin conductance (SC) measurements have detected increased sweating in newborn infants >28 gestational age (GA) submitted to heel lancing.Objective: To measure SC during heel lancing and routine care in newborn infants, born at 22 to 27 GA, with special relation to postnatal age (PNA).Methods: In six infants (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542263 Mon, 26 Dec 2011 10:48:08 +0100 5542263 http://www.medworm.com/index.php?rid=5542262&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003525%2Fabstract%3Frss%3Dyes Abstract: Fetal intervention encompasses a range of procedures on the fetus with congenital structural anomalies, whilst still on the placental circulation. The concept of fetal surgery was conceived in order to prevent fetal or early postnatal death, or to prevent permanent irreversible organ damage. The benefit of these procedures has to be balanced with risks to both the mother and the fetus. Open fetal surgery, more commonly conducted in North American centres, involves open surgery to the uterus in order to operate on the fetus. Fetal intervention centres in Europe more commonly use minimally invasive fetoscopic surgery. This paper elaborates on the various strategies used in dealing with anomalies of different organ systems of the fetus. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542262 Mon, 26 Dec 2011 10:48:08 +0100 5542262 http://www.medworm.com/index.php?rid=5542261&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003501%2Fabstract%3Frss%3Dyes Abstract: Foetal counselling is best achieved by a multidisciplinary team that can favourably influence the perinatal management of prenatally diagnosed anomalies and provide this information to prospective parents. Prenatal diagnosis has remarkably improved our understanding of surgically correctable congenital malformations. It has allowed us to influence the delivery of the baby, offer prenatal surgical management and discuss the options of termination of pregnancy for seriously handicapping or lethal conditions. Antenatal diagnosis has also defined an in utero mortality for some lesions such as diaphragmatic hernia and sacrococcygeal teratoma so that true outcomes can be measured. The limitation of in-utero diagnosis cannot be ignored. The aim of prenatal counselling is to provide info... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542261 Mon, 26 Dec 2011 10:48:08 +0100 5542261 http://www.medworm.com/index.php?rid=5542260&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003495%2Fabstract%3Frss%3Dyes Abstract: Up to 3% of UK pregnancies will be affected by congenital abnormality. Prenatal diagnosis allows the parents to make informed decisions about their pregnancy, healthcare professionals to optimise the antenatal care and families prepare for the birth of the baby. There are many techniques employed which range from the non-invasive ultrasonography to the highly invasive amniocentesis. This review explores the methods currently available in the UK as well as considering the newer minimally-invasive technologies available including cell-free fetal DNA and pre-implantation genetic diagnosis. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542260 Mon, 26 Dec 2011 10:48:08 +0100 5542260 http://www.medworm.com/index.php?rid=5542259&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003513%2Fabstract%3Frss%3Dyes Despite improvements in perinatal care serious birth defects still account for 20% of all deaths in the newborn period and an even greater percentage of serious morbidity later in infancy and childhood. The major causes of congenital malformation are chromosomal abnormalities, mutant genes, multifactorial disorders and teratogenic agents. Prenatal diagnosis has remarkably improved our understanding of congenital structural anomalies, however the diagnosis and management of these complex fetal anomalies, require a multidisciplinary team encompassing obstetricians, neonatologists, geneticists, paediatricians, paediatric surgeons and occasional other specialist with expertise to deal with all the maternal and fetal complexities. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542259 Mon, 26 Dec 2011 10:48:08 +0100 5542259 http://www.medworm.com/index.php?rid=5542258&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003653%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5542258 Mon, 26 Dec 2011 10:48:08 +0100 5542258 http://www.medworm.com/index.php?rid=5428188&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100212X%2Fabstract%3Frss%3Dyes Conclusions: Binge drinking once a week during pregnancy week 0–6 had stronger predictive power of difficult temperament and sleeping problems during infancy, than other covariates. The findings support advising women to avoid binge drinking when planning pregnancy.Highlights: ► Weekly binge drinking in very early pregnancy increase the chance of infant difficult temperament. ► Weekly binge drinking in very early pregnancy increase the chance of infant sleeping problems. ► Early binge drinking was a stronger predictor than maternal depression and infant birth weight. ► Infant temperament may be a precursor for later problems associated with fetal alcohol exposure. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428188 Sun, 20 Nov 2011 11:06:30 +0100 5428188 http://www.medworm.com/index.php?rid=5428187&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002118%2Fabstract%3Frss%3Dyes Abstract: Background: Late-onset sepsis is a relatively common complication particularly of preterm birth that affects approximately a quarter of very low birth weight infants.Aim: We aimed to determine the motor, cognitive, and behavioural outcome at school age of preterm children with late-onset sepsis compared to matched controls.Study design and subjects: A prospective case–control study that included preterm infants (gestational age (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428187 Sun, 20 Nov 2011 11:06:30 +0100 5428187 http://www.medworm.com/index.php?rid=5428186&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002106%2Fabstract%3Frss%3Dyes Conclusions: Exposure to stressful events during pregnancy influences birth outcomes independently of other factors. Exposure timing, newborn sex, and the type of stressor influence the effects observed. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428186 Sun, 20 Nov 2011 11:06:30 +0100 5428186 http://www.medworm.com/index.php?rid=5428185&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100209X%2Fabstract%3Frss%3Dyes Conclusion: Maternal stress is an important correlate of behavior problems for children with hearing loss and should be considered by Early Intervention providers. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428185 Sun, 20 Nov 2011 11:06:30 +0100 5428185 http://www.medworm.com/index.php?rid=5428184&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002088%2Fabstract%3Frss%3Dyes I read with great interest the article by Bishop N . The author in the treatment part of osteogenesis imperfecta (OI) has described that, studies reported so far have focused on the use of pamidronate given intravenously. The author has not described about the recent reports of use of zoledronate in treatment of different types of OI. Though the reported experience of bisphosphonates (BPs) use in OI relates primarily to the use of pamidronate (one to three intravenous infusions every 2–3months), zoledronate is a third generation BP having higher potency and affinity than pamidronate (up to 1000 times for bone) resulting in longer duration of action that lasts for 6–12months. Zoledronate is emerging as a newer therapy for children with OI, if we discuss some recent studies. (Source: Ear... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428184 Sun, 20 Nov 2011 11:06:30 +0100 5428184 http://www.medworm.com/index.php?rid=5428183&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002076%2Fabstract%3Frss%3Dyes This study assesses the usefulness of the ATNAT in the prediction of developmental problems at two years of corrected age (CA) in infants born between 29 and 37 weeks of gestation.Method: Inclusion criteria were: gestational age between 290/7 and 366/7 weeks inclusively, birth weight below 2500g and minimal 24-hour stay in the Neonatal Intensive Care Unit of Sainte-Justine Hospital. A sample of 147 was prospectively recruited and assessed at two ages: at term with the ATNAT and at 24months CA with Bayley Scales of Infant Development–II.Results: No major impairment such as cerebral palsy and no neurosensory impairment were observed. Developmental delay defined by an index (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428183 Sun, 20 Nov 2011 11:06:30 +0100 5428183 http://www.medworm.com/index.php?rid=5428182&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002064%2Fabstract%3Frss%3Dyes Abstract: Background: Early iron supplementation in women with sufficient reserves could provoke iron excess resulting in haemoconcentration and low infant birth weight (IBW).Aim: To clarify the influence of early iron supplementation on maternal iron status and the IBW, taking into account pre-pregnancy iron deposits.Study design: Longitudinal, prospective study.Subjects: Healthy women volunteers (n=82) intending to become pregnant.Outcome measures: Women were grouped as a function of their pre-pregnancy (low or present) iron stores (serum ferritin (SF) (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428182 Sun, 20 Nov 2011 11:06:30 +0100 5428182 http://www.medworm.com/index.php?rid=5428181&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002052%2Fabstract%3Frss%3Dyes Conclusion: The quality of lifestyle prior to conception is critical: prenatal counselling needs to be undertaken prior to conception. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428181 Sun, 20 Nov 2011 11:06:30 +0100 5428181 http://www.medworm.com/index.php?rid=5428180&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002040%2Fabstract%3Frss%3Dyes Abstract: Thymosin beta 10 (Tβ10) is a member of beta-thymosins (Tβs), a family of low molecular mass peptides abundant in many cell types. In previous studies, Tβs have been shown to play essential roles in many cellular functions, including cytokinesis, migration and endocytosis. Recently, Tβ10 has been found in high quantities in the saliva of human newborns, while it disappeared in the adults. On the basis of these data, it seemed of some interest to study the influence of Tβ10 during the development of the human salivary glands. To this end, we analyzed, using immunocytochemistry, the expression of Tβ10 in samples of the major and minor salivary glands obtained, at autopsy, from 2 human fetuses and 4 newborns, ranging from 13 up to 33weeks of gestation. Tβ10 immunoreactivity wa... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428180 Sun, 20 Nov 2011 11:06:30 +0100 5428180 http://www.medworm.com/index.php?rid=5428179&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002039%2Fabstract%3Frss%3Dyes Discussion: Sodium alginate doesn't reduce the total number of AOP nor GOR-related apnoeas. On the other hand, it reduces acid GOR features, while it had no effect on non-acid GOR indexes. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428179 Sun, 20 Nov 2011 11:06:30 +0100 5428179 http://www.medworm.com/index.php?rid=5428178&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002027%2Fabstract%3Frss%3Dyes Conclusion: The prevalence of motor delay in the studied sample was high, suggesting that biological and ambient conditions of risk present in CF contribute to early motor deficits. Thus, the observation of the motor development in these patients is important for planning an adequate intervention. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428178 Sun, 20 Nov 2011 11:06:30 +0100 5428178 http://www.medworm.com/index.php?rid=5428177&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003422%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5428177 Sun, 20 Nov 2011 11:06:30 +0100 5428177 http://www.medworm.com/index.php?rid=5375668&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100274X%2Fabstract%3Frss%3Dyes Abstract: Drug development is crucial to improving the care given to neonates through new and existing medicines. Pressure from regulatory agencies has improved the way in which pharmaceutical companies work with neonates. This provides new opportunities for the neonatal community. This paper describes the issues that arise during the development of new drugs and considers how the contemporary approach to new drugs can inform research on existing drugs. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375668 Tue, 01 Nov 2011 04:00:00 +0100 5375668 http://www.medworm.com/index.php?rid=5375667&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002763%2Fabstract%3Frss%3Dyes Abstract: Son preference remains common in countries from East Asia through South Asia to the Middle East and North Africa. Where sex selective technology and abortion are readily available, such as in China, South Korea and India, this has led to a marked excess in male births. Worst excesses are seen in parts of rural China where there are 140 male births for every 100 female. This leads to large numbers of unmarriageable men. Concerns about the consequences centre around the propensity to aggression and violence of these men with increased levels of crime and antisocial behaviour, threatening societal stability and security. But recent studies do not support these assumptions, but rather suggest that these men are marginalised, lonely, withdrawn and prone to psychological problems. Meas... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375667 Tue, 01 Nov 2011 04:00:00 +0100 5375667 http://www.medworm.com/index.php?rid=5375666&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002775%2Fabstract%3Frss%3Dyes This article reviews the evolution of the current treatment strategies in congenital diaphragmatic hernia and its future directions. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375666 Tue, 01 Nov 2011 04:00:00 +0100 5375666 http://www.medworm.com/index.php?rid=5375665&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002799%2Fabstract%3Frss%3Dyes Abstract: Delivery room (DR-) management has a great potential to optimise quality of long term outcome in extremely preterm infants. However, a new conceptual framework that focuses on an individualised ‘support of transition’ rather than on ‘resuscitation’ is necessary.Video-recordings of DR-management represent a valuable tool to improve care. Recording combined with a structured feed-back should be introduced in step-wise approach in clinical routine.To describe the postnatal condition of groups of infants or to compare interventions in a research setting, a numerical score – representing the sum of several objective findings – is required. The conventional Apgar-Score has severe limitations that restrict its applicability. The Specified-Apgar allows an assessment of infant... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375665 Tue, 01 Nov 2011 04:00:00 +0100 5375665 http://www.medworm.com/index.php?rid=5375664&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002787%2Fabstract%3Frss%3Dyes Abstract: Alterations of the intrauterine and neonatal environment may predispose for disorders and diseases throughout later life (perinatal programming). Especially, hormones and nutrients are dose-dependent organizers of the developing organism. Studies in offspring of diabetic mothers (ODM) have paradigmatically contributed to the perception of this developmental principle and our understanding of causal mechanisms. Fetal and neonatal hyperinsulinism in consequence of materno-fetal hyperglycaemia is the pathognomic feature in ODM. Epidemiological, clinical, as well as experimental data indicate that both insulin and glucose, when occurring in elevated concentrations during perinatal life, may epigenetically program a predisposition for obesity and diabetes later on. Similar may occur d... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375664 Tue, 01 Nov 2011 04:00:00 +0100 5375664 http://www.medworm.com/index.php?rid=5375663&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002805%2Fabstract%3Frss%3Dyes Abstract: Without security, adequate healthcare is not possible. Armed conflicts continue to be waged with pregnant women and girls, babies and children affected most. Most countries in conflict are poorly resourced and their mortality and morbidity statistics so much higher than rich countries that nothing short of a global revolution to create equity is going to solve the problem. When the arms trade is added in and analysed the maternal and child mortality rates for those countries exporting most of these killing machines is so much lower than the countries in which they are used that we have an ethical issue that must be addressed by health professionals. Armed conflict is probably the most serious global public health challenge and two solutions are proposed. Health professionals have... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375663 Tue, 01 Nov 2011 04:00:00 +0100 5375663 http://www.medworm.com/index.php?rid=5375662&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002829%2Fabstract%3Frss%3Dyes Abstract: Inequalities in child health are of major concern to policymakers, public health specialists and clinicians. This review of studies within the context of the Generation R study illustrates that inequalities in population health, at least partly, originate in pregnancy and early childhood. The review shows inequalities with regard to the health of the pregnant mother, with regard to the growth of the fetus, with regard to birth outcomes, and with regard to health indicators in early childhood. These results are shown with regard to both biological/somatic outcomes, as well as with regard to psychosocial outcomes and healthy lifestyles. Both socioeconomic inequalities and ethnic inequalities in health are present. Although some inequalities can be explained by known determinants, r... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375662 Tue, 01 Nov 2011 04:00:00 +0100 5375662 http://www.medworm.com/index.php?rid=5375661&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002817%2Fabstract%3Frss%3Dyes Abstract: CMV is the most common congenital infection in newborns worldwide. Congenital CMV causes sensorineural hearing loss in a significant proportion of infected newborns, while the majority of newborns are asymptomatic. In the last three years there have been significant advances in the diagnosis and treatment of congenital CMV. We have developed practical evidence based guidelines for the management of congenital CMV. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375661 Tue, 01 Nov 2011 04:00:00 +0100 5375661 http://www.medworm.com/index.php?rid=5375660&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002751%2Fabstract%3Frss%3Dyes Abstract: Public health recommendations should be based on the best available scientific evidence, and this necessitates careful appraisal of the available data and management of scientific uncertainty. This paper discusses the difficulties in collecting and interpreting scientific data on infant feeding, in particular the fact that since it is not feasible to randomise healthy infants to be breast or formula-fed, the majority of available data come from observational studies with associated methodological limitations. The scientific evidence available to underpin recommendations for breastfeeding and for 6months exclusive breastfeeding are presented in the context of these limitations, noting disagreement between expert groups considering the same scientific data. Finally, the use of scie... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375660 Tue, 01 Nov 2011 04:00:00 +0100 5375660 http://www.medworm.com/index.php?rid=5375659&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003057%2Fabstract%3Frss%3Dyes Abstract: Neonatologists and paediatricians have a crucial role working with mothers at the most nutritionally challenged point in their lives and that of their infants. This position of responsibility is particularly important in tackling the re-emerging problem of hypovitaminosis D. In this overview the role of vitamin D, its contribution to pathology in those to whom we provide a service and possible actions will be considered. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375659 Tue, 01 Nov 2011 04:00:00 +0100 5375659 http://www.medworm.com/index.php?rid=5375658&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211003112%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5375658 Tue, 01 Nov 2011 04:00:00 +0100 5375658 http://www.medworm.com/index.php?rid=5246451&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002015%2Fabstract%3Frss%3Dyes Conclusion: Children born at 32 to 36weeks' gestational age do not experience an overall lower HR-QoL at 2 to 5years of age. CPAP results in lower HRQoL scores for lung problems. The overall occurrence of behavioral and emotional problems does not differ from the general term-born pediatric population. Several subitems need further attention. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246451 Fri, 23 Sep 2011 11:36:22 +0100 5246451 http://www.medworm.com/index.php?rid=5246450&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002003%2Fabstract%3Frss%3Dyes Conclusions: These qEEG norms are highly useful as an aid to visual interpretation and for the study of pathology further evolution as well as for assessment of infants showing brain risk factors. To our knowledge this is the first normative qEEG study for the initial year of life with such large sample and validation-group. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246450 Fri, 23 Sep 2011 11:36:22 +0100 5246450 http://www.medworm.com/index.php?rid=5246449&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100199X%2Fabstract%3Frss%3Dyes This article reviews new information available on the molecular pathogenesis of ROP which may result in novel treatments for ROP; it does not discuss the well-known role of oxygen in the development of ROP. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246449 Fri, 23 Sep 2011 11:36:22 +0100 5246449 http://www.medworm.com/index.php?rid=5246448&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001988%2Fabstract%3Frss%3Dyes Abstract: Background: In asphyxiated term and near-term infants, therapeutic hypothermia increases survival without neurologic morbidity, and extending this new treatment to preterm infants is being debated.Aims: To investigate the association of low pH and base excess (BE) at birth or admission, as used as entry criteria in cooling trials, and evolving brain damage in preterm infants.Study design and measurements: Rates of death and neurodevelopmental impairment at 12 and 20months corrected age were assessed in a cohort of 1137 preterm infants with a gestational age (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246448 Fri, 23 Sep 2011 11:36:22 +0100 5246448 http://www.medworm.com/index.php?rid=5246447&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001903%2Fabstract%3Frss%3Dyes Conclusions: Use of the French ASQ in a research cohort appears feasible as response rates were high. Moreover, known links between child development measured by ASQ and birth and social characteristics were observed. However, further French studies are needed to understand differences observed in 12-month ASQ gross motor scores compared with US norms. For research purposes, further analysis of the ASQ in innovative, quantitative approaches, is needed. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246447 Fri, 23 Sep 2011 11:36:22 +0100 5246447 http://www.medworm.com/index.php?rid=5246446&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001897%2Fabstract%3Frss%3Dyes Abstract: Poor fetal growth is associated with decrements in muscle strength likely due to changes during myogenesis. We investigated the association of poor fetal growth with muscle strength, fatigue resistance, and the response to training in the isolated quadriceps femoris. Females (20.6years) born to term but below the 10th percentile of ponderal index (PI)-for-gestational-age (LOWPI, n=14) were compared to controls (HIGHPI, n=14), before and after an 8-week training. Muscle strength was assessed as grip-strength and as the maximal isometric voluntary contraction (MVC) of the quadriceps femoris. Muscle fatigue was assessed during knee extension exercise. Body composition and the maximal oxygen consumption (VO2max) were also measured. Controlling for fat free mass (FFM), LOWPI versus HI... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246446 Fri, 23 Sep 2011 11:36:22 +0100 5246446 http://www.medworm.com/index.php?rid=5246445&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001873%2Fabstract%3Frss%3Dyes In this study, we aimed to investigate the value of serum I-FABP in early diagnosis and predicting severity of NEC.Methods: This prospective study was conducted between April 2009 and November 2009. The preterm infants with suspected NEC were included in the study. These infants were divided into two groups according to their final diagnoses; Group 1: Stage 1 NEC and Group 2: Stages 2–3 NEC (Group 2a: Stage 2 NEC, Group 2b: Stage 3 NEC). Healthy preterms were assigned to control group (Group 3). Serial blood samples were obtained from the patients at symptom onset, 24h and 72h later. One blood sample was taken from the controls. Serum I-FABP levels were compared among the groups.Results: Initial serum I-FABP concentrations were 324.0±165.8pg/ml, 764.7±465.1pg/ml, and 360.2±439.5pg/ml ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246445 Fri, 23 Sep 2011 11:36:22 +0100 5246445 http://www.medworm.com/index.php?rid=5246444&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001861%2Fabstract%3Frss%3Dyes Abstract: Aims: This retrospective, population based study was designed to investigate risk factors for development of retinopathy of prematurity (ROP) and their possible interrelationships, in neonates of gestational age (GA) grade 2: 6). Logistic regression analysis showed ROP to be strongly associated with GA, odds ratio (OR) 2.1, confidence interval (CI) 1.3–3.3, p (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246444 Fri, 23 Sep 2011 11:36:22 +0100 5246444 http://www.medworm.com/index.php?rid=5246443&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100185X%2Fabstract%3Frss%3Dyes Abstract: Objective: To determine the pattern and predictors of growth velocity in early infancy in a resource-poor setting.Methods: Weight velocity between birth and first postnatal visit was determined in a cohort of preterm and full-term infants in Lagos, Nigeria using three mathematical methods reported in the literature. Maternal and infant factors predictive of weight velocity were identified by multiple linear regression analysis.Results: Overall, 658 infants were enrolled with mean gestational age of 37.7±2.0weeks, birthweight of 3.2±0.6kg and median age of 45 (interquartile range: 42–48) days at follow-up. Offspring of older and HIV-positive mothers had significantly lower mean weight velocities while male infants and those with low birthweight and fetal growth restriction had... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246443 Fri, 23 Sep 2011 11:36:21 +0100 5246443 http://www.medworm.com/index.php?rid=5246442&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002878%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5246442 Fri, 23 Sep 2011 11:36:21 +0100 5246442 http://www.medworm.com/index.php?rid=5217754&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001848%2Fabstract%3Frss%3Dyes Abstract: Background: Infant mortality is an important indicator of the health and wellness of a society. Multiple risk factors for infant mortality have been identified and investigated; however, the influence of prior pregnancy experience on subsequent infant mortality is under-researched.Aims: To examine the association between stillbirth in the first pregnancy and risk for infant mortality in the second pregnancy in a large population-based dataset.Study design: Population-based, retrospective cohort studySubjects: Missouri maternally linked cohort data files were utilized from 1989 through 2005. Analyses were restricted to women who had two singleton pregnancies during the study period.Outcome measures: The exposure was stillbirth in the first pregnancy, while the primary outcome was ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217754 Thu, 01 Sep 2011 04:00:00 +0100 5217754 http://www.medworm.com/index.php?rid=5217753&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001836%2Fabstract%3Frss%3Dyes Conclusions: We were not able to exactly reproduce the generally very good results. In our clinical setting now videos are evaluated by at least two trained therapists and the results are discussed, if necessary, to reach a consensus. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217753 Thu, 01 Sep 2011 04:00:00 +0100 5217753 http://www.medworm.com/index.php?rid=5217752&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001885%2Fabstract%3Frss%3Dyes The objective of this review was to provide a critical overview of our current understanding on the neurocognitive, neuromotor, and neurobehavioral development in congenital diaphragmatic hernia (CDH) patients, focusing on three interrelated clinical issues: (1) comprehensive outcome studies, (2) characterization of important predictors of adverse outcome, and (3) the pathophysiological mechanism contributing to neurodevelopmental disabilities in infants with CDH. Improved survival for CDH has led to an increasing focus on longer-term outcomes. Neurodevelopmental dysfunction has been recognized as the most common and potentially most disabling outcome of CDH and its treatment. While increased neuromotor dysfunction is a common problem during infancy, behavioral problems, hearing impairment... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217752 Thu, 01 Sep 2011 04:00:00 +0100 5217752 http://www.medworm.com/index.php?rid=5217751&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002465%2Fabstract%3Frss%3Dyes Abstract: In isolated congenital diaphragmatic hernia, lung size and/or the position of the liver are predictive of neonatal outcome. Percutaneous Fetal Endoscopic Tracheal Occlusion (FETO) by a balloon can be undertaken to prompt lung growth in the worst cases. The feasibility and safety of FETO is no longer at stake, and it is associated with an apparent increase in neonatal survival. The gestational age at birth, the pre-existing lung size, the ability to remove the balloon prior to birth, and the lung response are predicting outcome. The most frequent complication is preterm premature rupture of the membranes, and as a consequence preterm delivery, which also complicates balloon removal. We have set up a randomized trial for the formal evaluation of FETO in Europe, including criteria f... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217751 Thu, 01 Sep 2011 04:00:00 +0100 5217751 http://www.medworm.com/index.php?rid=5217750&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002313%2Fabstract%3Frss%3Dyes Abstract: Congenital lung lesions, mostly congenital cystic adenomatoid malformations (CCAMs) and bronchopulmonary sequestrations (BPSs), are uncommon disorders. Prenatal intervention in severely affected (hydropic) fetuses has drastically improved perinatal survival. Not much is known, however, on the short-term and long-term respiratory and neurodevelopmental outcome. Several small case series have been reported and suggest an increased incidence of neonatal morbidity, mainly associated with prematurity and respiratory failure at birth. Overall, neonatal mortality and morbidity after prenatal interventions for CCAM seems to be worse than for BPS. This review focuses on the neonatal outcome after prenatal intervention for congenital lung lesions and summarizes the results reported in the ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217750 Thu, 01 Sep 2011 04:00:00 +0100 5217750 http://www.medworm.com/index.php?rid=5217749&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002271%2Fabstract%3Frss%3Dyes Abstract: Congenital lower urinary tract obstruction (LUTO) is a heterogeneous group of pathologies, the most common being posterior urethral valves (PUV) or urethral atresia. The bladder neck obstruction in utero leads to a spectrum of disease including mild oligohydramnios with normal renal function to a picture of severe oligohydramnios associated with chronic obstructive macro/microcystic renal parenchymal disease leading to chronic renal impairment. These anomalies may be isolated or complex; the latter being associated with other structural or chromosomal abnormalities. If isolated, the congenital bladder neck obstruction may be amenable to in-utero therapy. In a significant proportion of babies affected by LUTO there is severe oligohydramnios (occurring before 20weeks gestation) and... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217749 Thu, 01 Sep 2011 04:00:00 +0100 5217749 http://www.medworm.com/index.php?rid=5217748&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002301%2Fabstract%3Frss%3Dyes Abstract: Monochorionic (MC) twins are at risk for several disorders, including twin–twin transfusion syndrome (TTTS), Twin Reverse Arterial Perfusion (TRAP) and selective intrauterine growth restriction (sIUGR). Several fetal interventions, such as serial amnioreduction (AR), fetoscopic laser coagulation of placental anastomoses (FLC) and selective feticide have lead to improved perinatal morbidity and mortality rates. Nevertheless, the rate of cerebral lesions in MC twins after fetal therapy appears to be high. Follow-up studies show a high incidence of cerebral palsy (CP) and neurodevelopmental impairment (NDI). We performed a systematic review on the long-term neurodevelopmental outcome in MC twins with TTTS following AR and FLC and MC twins following selective feticide of the co-twi... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217748 Thu, 01 Sep 2011 04:00:00 +0100 5217748 http://www.medworm.com/index.php?rid=5217747&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002295%2Fabstract%3Frss%3Dyes Abstract: Twin–twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies associated with high perinatal mortality and morbidity rates. Management in TTTS is a major challenge for obstetricians and neonatologists. Twins which are often born prematurely and may suffer from typical conditions associated with prematurity. In addition, surviving twins with TTTS are at increased risk for other complications including neurological, cardiovascular, renal and hematologic morbidity. Rare complications such as hypoxic–ischemic lesions to limbs or intestines and amniotic band syndrome have also been reported in TTTS survivors.This review focuses on the neonatal and pediatric mortality and morbidity in TTTS survivors, with special emphasis on the long-term neurodev... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217747 Thu, 01 Sep 2011 04:00:00 +0100 5217747 http://www.medworm.com/index.php?rid=5217746&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100226X%2Fabstract%3Frss%3Dyes Abstract: The long-term neurodevelopmental outcome of children born after intrauterine blood transfusion (IUT) for red cell alloimmunization is considered favorable. Severe hydrops has been identified as a strong predictor for neurodevelopmental impairment. However, the long-term outcome of survivors of IUT for congenital Parvovirus B19 infection and fetomaternal hemorrhage is not well known. Limitations of the follow-up studies to date are small sample size, lack of controls, unclear criteria for impairment and lack of standardized developmental tests. Future research should take into account more subtle impairments, since cognitive functioning (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217746 Thu, 01 Sep 2011 04:00:00 +0100 5217746 http://www.medworm.com/index.php?rid=5217745&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002337%2Fabstract%3Frss%3Dyes Abstract: Treatment of severe anemia with intrauterine red cell transfusions in fetuses with red cell alloimmunization has led to a dramatic increase in perinatal survival. Due to this increased survival focus is nowadays shifting towards improving postnatal treatment options. Phototherapy, exchange transfusions and intravenous immunoglobulin are used to treat hyperbilirubinemia and prevent kernicterus. Postnatal treatment of anemia consists of top-up transfusions, supplements to support erythropoiesis such as folic acid and iron, and occasionally erythropoietin treatment. In addition to anemia, other hematological complications such as thrombocytopenia, coagulation disturbances, leucopenia and iron overload have been reported. This review focuses on the hematological morbidity in neonates... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217745 Thu, 01 Sep 2011 04:00:00 +0100 5217745 http://www.medworm.com/index.php?rid=5217744&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002283%2Fabstract%3Frss%3Dyes Advances in ultrasound techniques and screening programs have resulted in timely detection of an increasing number of fetal diseases, some of which may benefit from fetal surgical intervention. The most commonly performed invasive fetal treatments are intrauterine blood transfusion (IUT) for severe fetal anemia and fetoscopic laser coagulation of vascular anastomoses in the placenta of monochorionic twins with twin-to-twin transfusion syndrome (TTTS) . Ultrasound-guided insertion of a thoraco-amniotic shunt is increasingly advocated as treatment in hydropic fetuses with primary hydrothoraces and/or space-occupying congenital lung lesions, such as congenital cystic adenomatoid malformations (CCAM) , and vesico-amniotic shunting is available as intervention in congenital lower urinary tract ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217744 Thu, 01 Sep 2011 04:00:00 +0100 5217744 http://www.medworm.com/index.php?rid=5217743&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002581%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5217743 Thu, 01 Sep 2011 04:00:00 +0100 5217743 http://www.medworm.com/index.php?rid=5048395&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001824%2Fabstract%3Frss%3Dyes Abstract: Introduction: The macronutrient concentrations of human milk could be influenced by the various processes used in human milk bank.Aims: To determine the effect of various process (Holder pasteurization, freezing and thawing and feeding method) on the macronutrient concentration of human milk.Methods: The samples of donated fresh human milk were studied before and after each process (Holder pasteurization, freezing and thawing and feeding method) until their delivery to newborn infants. Fifty-seven raw human milk samples were analyzed in the first step (pasteurization) and 228 in the offer step. Repeated measurements of protein, fat and lactose amounts were made in samples of human milk using an Infrared analyzer. The influence of repeated processes on the mean concentration of ma... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048395 Fri, 22 Jul 2011 00:02:29 +0100 5048395 http://www.medworm.com/index.php?rid=5048394&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001812%2Fabstract%3Frss%3Dyes Abstract: Despite advances in diagnosis and management, non-immune hydrops fetalis (NIHF) has a high mortality rate. Perinatal survival depends on the underlying disorder and the gestational age at diagnosis. As prognostic information is limited, this study acquired data regarding the neurological development of perinatal survivors.We performed a retrospective chart review of 214 cases in which NIHF was diagnosed antenatally. We recorded maternal demographic characteristics and interventions and their effectiveness, as well as the short-term outcome (survival) and long-term outcome including developmental quotients. Among the affected fetuses, 91 (42.5%) survived the perinatal period. Fetuses with chylothorax, chyloascites, or meconium peritonitis, and those in whom therapy was effective, ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048394 Fri, 22 Jul 2011 00:02:29 +0100 5048394 http://www.medworm.com/index.php?rid=5048393&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001800%2Fabstract%3Frss%3Dyes Conclusions: Exposure to antenatal maternal anxiety is associated with children's problem behaviour, with different outcome patterns for both sexes. Nevertheless, effect sizes in this study were small. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048393 Fri, 22 Jul 2011 00:02:29 +0100 5048393 http://www.medworm.com/index.php?rid=5048392&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001794%2Fabstract%3Frss%3Dyes Conclusion: Although exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048392 Fri, 22 Jul 2011 00:02:29 +0100 5048392 http://www.medworm.com/index.php?rid=5048391&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001782%2Fabstract%3Frss%3Dyes Abstract: Background and aim: To establish, using echocardiography, color-flow Doppler and tissue doppler imaging (TDI), physiological values of systolic/diastolic indexes in healthy term/pre-term newborns, and to identify how different degrees of maturity influence morpho-functional cardiac alterations during the transitional period.Study design and subjects: 33 term newborns (M=19, F=14; gestational ages: 37th–41st week), and 20 pre-term infants (M=11, F=9; gestational ages: 31st–36th week) admitted to our department were studied. All infants underwent to clinical and Doppler ultrasound evaluations, carried out by the third to fourth day. Investigations included: M-mode echocardiography, color-flow Doppler and TDI.Outcome measures and results: Term and preterm neonates differed for: ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048391 Fri, 22 Jul 2011 00:02:29 +0100 5048391 http://www.medworm.com/index.php?rid=5048390&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100171X%2Fabstract%3Frss%3Dyes Abstract: Background: The identification of growth-restricted neonates is hampered by the lack of an appropriate diagnostic tool.Aim: To determine the value of combining diagnostic markers in detecting growth-restricted neonates.Methods: A set of anthropometric indices, nutritional status and placental weight were assessed in the study population soon after birth. Insulin-like growth factor I (IGF-I) and its binding protein 3 (IGFBP-3) were assayed in cord blood. Babies having low values (≤25th centile for gestational age) in 0, 1 or more of four anthropometric indices were classified as Group250, Group251 and Group252, respectively. For statistical evaluation the Mann–Whitney test and a multiple regression analysis were performed.Results: One hundred-eighty (180) singleton babies of o... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048390 Fri, 22 Jul 2011 00:02:29 +0100 5048390 http://www.medworm.com/index.php?rid=5048389&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100168X%2Fabstract%3Frss%3Dyes Conclusions: The technique that was developed and validated proved capable of measuring temporal parameters of sucking in breastfeeding newborns. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048389 Fri, 22 Jul 2011 00:02:28 +0100 5048389 http://www.medworm.com/index.php?rid=5048388&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001678%2Fabstract%3Frss%3Dyes Abstract: Background: Since the early 90s a striking rise in deformational plagiocephaly (DP) has been reported, and a causal link between the “back to sleep” position recommended to reduce the risk of sudden infant death syndrome. Recent data suggested that supine position is a risk factor only when combined with other environmental factorsObjective: To evaluate the impact of early intervention in the newborn environment on the prevalence of DP at 4months of life.Methods: A multicentric, prospective, controlled study in healthy term neonates. Within 72h of birth, all parents received the usual recommendations for positioning their infants to prevent sudden infant death syndrome. In the Intervention group, recommendations were also given to encourage spontaneous and unhindered physical... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048388 Fri, 22 Jul 2011 00:02:28 +0100 5048388 http://www.medworm.com/index.php?rid=5048387&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001666%2Fabstract%3Frss%3Dyes Conclusion: Children born after preeclampsia may show effects of a negative impact on the heart already at the age of 5 to 8years. The numbers of examined children were, however, limited. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048387 Fri, 22 Jul 2011 00:02:28 +0100 5048387 http://www.medworm.com/index.php?rid=5048386&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001654%2Fabstract%3Frss%3Dyes Conclusions: Duct ectasia should be entertained in small infants and children presenting with both small and large peri-areolar breast masses and/or bleeding. The occurrence of the disease in infants suggests that mammary duct ectasia may represent a developmental anomaly in the paediatric population. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048386 Fri, 22 Jul 2011 00:02:27 +0100 5048386 http://www.medworm.com/index.php?rid=5048385&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001642%2Fabstract%3Frss%3Dyes Conclusion: There was no standardized care for jaundiced preterm infants in the Netherlands. In addition to the internationally used guideline for (near) term infants, a novel “consensus based” guideline for preterm infants with a gestational age of less than 35weeks has been developed and implemented in the Netherlands. This guideline is approved and recommended by the Dutch Society of Pediatrics. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048385 Fri, 22 Jul 2011 00:02:26 +0100 5048385 http://www.medworm.com/index.php?rid=5048384&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001630%2Fabstract%3Frss%3Dyes Abstract: Background: Sepsis is associated with an increased production of oxidant species and a decrease in endogenous antioxidant defenses. Mortality is high, especially when endotoxins are involved, e.g., in infants with Gram-negative sepsis. Yet, chronic as well as acute unconjugated hyperbilirubinemia has been shown to protect against endotoxin-induced shock in vivo in rats and in mice. We hypothesized that hyperbilirubinemia in infants with Gram-negative sepsis improves survival and/or mitigates the inflammatory response.Objective: To assess the relationships between serum bilirubin concentrations on the one hand, and leukocyte count, C-reactive protein and survival on the other hand, in infants with Gram-negative sepsis.Methods: Retrospectively, we retrieved clinical and biochemical... Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048384 Fri, 22 Jul 2011 00:02:26 +0100 5048384 http://www.medworm.com/index.php?rid=5048383&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211002210%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=5048383 Fri, 22 Jul 2011 00:02:26 +0100 5048383 http://www.medworm.com/index.php?rid=4920110&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001605%2Fabstract%3Frss%3Dyes Abstract: The intestinal microbiota in the breast-fed infant is considered as ideally healthy. We assessed the microbiota of breast-fed full-term neonates from two different Spanish locations. Statistically significant geographical differences for different bacterial groups were found, underlining the need to consider and define geographical-related effects on microbiota. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920110 Sat, 11 Jun 2011 02:49:26 +0100 4920110 http://www.medworm.com/index.php?rid=4920109&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001708%2Fabstract%3Frss%3Dyes We read with interest the article by Perrone et al. regarding the association of free-radical related diseases (FRDs) and biochemical markers of oxidative stress (OS) in infantile cord blood , testing the hypothesis that the levels of OS markers in cord blood might predict the onset of FRDs including retinopathy of prematurity (ROP). The authors noted that this study was of inadequate power to define the relative increase risk for each FRD, although globally the risk was increased with elevated cord blood levels of OS markers. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920109 Sat, 11 Jun 2011 02:49:26 +0100 4920109 http://www.medworm.com/index.php?rid=4920108&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001691%2Fabstract%3Frss%3Dyes Abstract: Background: Extremely low birth weight (ELBW) infants are at risk of impaired postnatal growth. Impaired postnatal growth has been reported to be associated with delayed cognitive and motor development.Aims: To describe postnatal growth patterns of appropriate and small for gestational age (AGA and SGA) ELBW children in relation to their cognitive and motor outcome at age 5.5.Study design: Retrospective cohort study.Subjects: One hundred one children with a BW≤750g, born between 1996 and 2005 in the University Hospital Utrecht, The Netherlands.Outcome measures: Height (Ht), weight (Wt), occipital–frontal circumference (OFC) at birth, 15months and 2years corrected age and 3.5 and 5.5years.Cognitive and motor outcome at 5.5years of age, classified as normal (Z-score ≥−1), m... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920108 Sat, 11 Jun 2011 02:49:26 +0100 4920108 http://www.medworm.com/index.php?rid=4920107&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001629%2Fabstract%3Frss%3Dyes Conclusions: Preterm children with DCD have difficulty with visual processing tasks. Praxis or motor planning poses a particular challenge for them. Motor dysfunction in extremely preterm children was related to poorer visual processing and motor planning and may relate to a cognitive processing problem. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920107 Sat, 11 Jun 2011 02:49:25 +0100 4920107 http://www.medworm.com/index.php?rid=4920106&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001617%2Fabstract%3Frss%3Dyes Conclusions: Our analysis validates the models behind our new approaches, and our results confirm the presence of cardio-respiratory coupling in early stages of development, particularly during periods of mild mechanosensory intervention, thus encouraging further application of our approach. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920106 Sat, 11 Jun 2011 02:49:25 +0100 4920106 http://www.medworm.com/index.php?rid=4920105&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001538%2Fabstract%3Frss%3Dyes Abstract: Breathing movements are one of the earliest fetal motor behaviors to emerge and are a hallmark of fetal well-being. Fetal respiratory sinus arrhythmia (RSA) has been documented but efforts to quantify the influence of breathing on heart rate (HR) and heart rate variability (HRV) are difficult due to the episodic nature of fetal breathing activity. We used a dedicated fetal biomagnetometer to acquire the magnetocardiogram (MCG) between 36 and 38weeks gestational age (GA). We identified and characterized a waveform observed in the raw data and independent component decomposition that we attribute to fetal diaphragmatic movements during breathing episodes. RSA and increased high frequency power in a time-frequency analysis of the IBI time-series was observed during fetal breathing p... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920105 Sat, 11 Jun 2011 02:49:24 +0100 4920105 http://www.medworm.com/index.php?rid=4920104&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001526%2Fabstract%3Frss%3Dyes Abstract: Aim: To evaluate the impact of endothelial progenitor cells (EPCs), a subset of committed circulatory stem cells, on the development of bronchopulmonary dysplasia (BPD) and other short term outcomes in a cohort of extremely premature newborns.Methods: Progenitor cells were quantified by flow cytometry at birth in 36 neonates born (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920104 Sat, 11 Jun 2011 02:49:24 +0100 4920104 http://www.medworm.com/index.php?rid=4920103&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001484%2Fabstract%3Frss%3Dyes Abstract: Background: Asthma during pregnancy may compromise the well-being of the fetus and potentially impact an infant's birth weight via different mechanisms.Aims: 1) To assess the influence of asthma during pregnancy on the incidence of LBW outcomes in white non-Hispanic (WNH) and black non-Hispanic (BNH) women. 2) To identify other risk factors that affect low birth weight (LBW) (birth weight (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920103 Sat, 11 Jun 2011 02:49:23 +0100 4920103 http://www.medworm.com/index.php?rid=4920102&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100082X%2Fabstract%3Frss%3Dyes Conclusion: At 6–10weeks' gestation there are sonographically detectable differences between euploid and trisomic embryos. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920102 Sat, 11 Jun 2011 02:49:23 +0100 4920102 http://www.medworm.com/index.php?rid=4920101&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001927%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4920101 Sat, 11 Jun 2011 02:49:23 +0100 4920101 http://www.medworm.com/index.php?rid=4812073&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001514%2Fabstract%3Frss%3Dyes Provost and Tremblay studied the apolipoprotein A-I (apoA-I), apoA-II, apoC-II, apoH and lipoprotein lipase (LPL) expression in the human fetal lung and determined that these four apolipoprotein genes present a narrow peak of elevated expression in the developing lung during 32–35weeks' gestation period, along with the observation that apoC-II and LPL showed a temporal and geographical correlation with surfactant lipid synthesis in preparation for birth . It is possible that this may contribute to the decrease in the incidence of respiratory distress syndrome (RDS) on late gestation. These results were very interesting to us, because we studied the distribution of triglyceide (TG) in the cord blood of preterm neonates . (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812073 Thu, 12 May 2011 05:44:12 +0100 4812073 http://www.medworm.com/index.php?rid=4812072&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001460%2Fabstract%3Frss%3Dyes Abstract: Background: Hypertensive disorders in pregnancy account for increased perinatal morbidity and mortality when compared to uneventful gestations.Aims: To analyze perinatal outcome of pregnancies complicated by different kinds of hypertension to uncomplicated pregnancies in a series of Italian women and to compare our data with series from other countries.Study design: The sample was divided into four groups of hypertensive women: chronic hypertension (CH), gestational hypertension (GH), preeclampsia (PE), and chronic hypertension complicated by preeclampsia (CHPE). One thousand normal pregnancies served as controls.Subjects: Neonatal features of the offspring of 965 Italian women with hypertension in pregnancy were evaluated.Measures: Gestational age, birthweight and the rate of sm... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812072 Thu, 12 May 2011 05:44:11 +0100 4812072 http://www.medworm.com/index.php?rid=4812071&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001472%2Fabstract%3Frss%3Dyes Abstract: Background: Cytokines and chemokines during perinatal period may involve the neurological development of newborns.Aims: We investigated the association of circulating chemokines during neonatal period with the outcome of premature infants.Study design: The prospective study enrolled 29 very low birth weight ( (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812071 Thu, 12 May 2011 05:44:11 +0100 4812071 http://www.medworm.com/index.php?rid=4812070&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001502%2Fabstract%3Frss%3Dyes Abstract: Background: Controversy exists regarding association of high levels of proinflammatory cytokines, neonatal morbidities and poor neurodevelopment outcome in very low birth weight infants.Objective: To determine association between severity of early inflammatory response and neurodevelopment outcome in high risk very low birth weight infants.Methods: Sixty-two very preterm infants with high risk for early-onset sepsis were followed up to 24months corrected age. Blood sample was collected for IL-6, IL-8, IL-10, IL-1β, and TNF-α analysis. Neurodevelopment outcome by Bayley Scales of Infant Development II was assessed at 22 to 24months. Magnetic Resonance Image was performed at least once during the first 12months.Results: In 24 (38.7%) MDI was (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812070 Thu, 12 May 2011 05:44:11 +0100 4812070 http://www.medworm.com/index.php?rid=4812069&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001496%2Fabstract%3Frss%3Dyes Conclusions: For families with very preterm children, parental mental health symptoms and child neurodevelopmental disability may identify families at risk of greater stress and burden who may benefit from additional support. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812069 Thu, 12 May 2011 05:44:11 +0100 4812069 http://www.medworm.com/index.php?rid=4812068&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001447%2Fabstract%3Frss%3Dyes Conclusions: Subcortical leucomalacia results from fluid accumulation and not necrosis. Predisposition to fluid accumulation may be age-related and due to impairment of fluid handling pathways which remain immature in this age group. Potential mechanisms are discussed. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812068 Thu, 12 May 2011 05:44:11 +0100 4812068 http://www.medworm.com/index.php?rid=4812067&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001459%2Fabstract%3Frss%3Dyes Abstract: Background: Leptin is involved in the regulation of food intake and energy expenditure and is therefore important for growth and brain development. Analytical methods used for leptin measurement in human milk differ widely in the literature and yield varying results.Aims: To compare different preparation methods for the analysis of leptin in human milk and to investigate the leptin levels in colostrum and mature human milk from mothers of preterm or term infants.Methods: Mothers delivering a preterm (n=37) or a term infant (n=40) were recruited for a prospective study and were ask to collect breast milk on the 3rd and 28th day of lactation. Leptin, protein and fat concentrations were analysed. Clinical data of mother and child were recorded prospectively.Results: Skim milk was mo... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812067 Thu, 12 May 2011 05:44:10 +0100 4812067 http://www.medworm.com/index.php?rid=4812066&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001423%2Fabstract%3Frss%3Dyes Conclusions: Our data show that elevated plasma maternal testosterone levels: (1) causes low birth weight followed by catch-up growth and hypertension in female offspring and (2) alters endothelium-dependent vascular responses. The endothelial dysfunction is associated with decreased activity/expression of eNOS. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812066 Thu, 12 May 2011 05:44:10 +0100 4812066 http://www.medworm.com/index.php?rid=4812065&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001435%2Fabstract%3Frss%3Dyes Conclusions: During the first two days and day 8 after birth cerebral oxygen saturation is lower and oxygen extraction higher in preterm infants following prenatal tobacco exposure. Our data suggest that prenatal tobacco exposure may have an effect on cerebral oxygenation of the infant. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812065 Thu, 12 May 2011 05:44:10 +0100 4812065 http://www.medworm.com/index.php?rid=4812064&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001356%2Fabstract%3Frss%3Dyes Conclusions: The knowledge of risk factor profiles may permit the development of strategies to prevent heavy colonization and subsequent invasive disease in high risk infants. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812064 Thu, 12 May 2011 05:44:09 +0100 4812064 http://www.medworm.com/index.php?rid=4812063&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001733%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4812063 Thu, 12 May 2011 05:44:09 +0100 4812063 http://www.medworm.com/index.php?rid=4722995&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001344%2Fabstract%3Frss%3Dyes Abstract: Background: The neonatal acute physiology score, SNAP-II, reflects the severity of illness in newborns. In term newborns, amplitude integrated EEG (aEEG), is depressed following asphyxia. In preterm infants aEEG is discontinuous, and therefore more difficult to assess compared to term infants.Aims: Our first aim was to investigate whether assessing aEEG amplitudes by calculating amplitude centiles was consistent with assessment by pattern recognition. Our second aim was to investigate whether the aEEGs of preterm infants were influenced by SNAP-II.Study Design and Subjects: We recorded aEEGs in 38 infants with a mean gestational age of 29.7weeks (26.0–31.8weeks) during the first five days of life. The mean recording time was 130min. The aEEGs were assessed by pattern recognitio... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722995 Mon, 18 Apr 2011 15:01:35 +0100 4722995 http://www.medworm.com/index.php?rid=4722994&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001332%2Fabstract%3Frss%3Dyes Conclusion: The trend in mortality is worrisome but does not contraindicate an aggressive approach to the clinically significant PDA that has bidirectional flow at the time of the echocardiogram. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722994 Mon, 18 Apr 2011 15:01:35 +0100 4722994 http://www.medworm.com/index.php?rid=4722993&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001320%2Fabstract%3Frss%3Dyes Conclusions: Maternal trait anxiety, depressive symptoms and stress had little negative influence on infant cognitive development. In fact, moderate psychosocial distress may slightly accelerate motor development in particular, and some aspects of language. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722993 Mon, 18 Apr 2011 15:01:34 +0100 4722993 http://www.medworm.com/index.php?rid=4722992&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001319%2Fabstract%3Frss%3Dyes Conclusions: Umbilical cord length is independently related to the outcome of ECV, whereas umbilical coiling index is not. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722992 Mon, 18 Apr 2011 15:01:34 +0100 4722992 http://www.medworm.com/index.php?rid=4722991&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001290%2Fabstract%3Frss%3Dyes This study investigated whether growth in head circumference was concordant with growth in body length.Subjects: Forty infants (16 males) were followed between the ages of 2days and 21months for durations ranging from 4 to 21months (2616 measurements).Study design: Longitudinal anthropometric measurements were assessed weekly (n=12), semi-weekly (n=24) and daily (n=4) during home visits. Individual head circumference growth was investigated for the presence of saltatory patterns. Coincident analysis tested the null hypothesis that head growth was randomly coupled to length growth.Results: Head circumference growth during infancy is saltatory (p (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722991 Mon, 18 Apr 2011 15:01:34 +0100 4722991 http://www.medworm.com/index.php?rid=4722990&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001307%2Fabstract%3Frss%3Dyes Abstract: Background: An inverse relationship exists between the rates of maternal smoking during pregnancy and children's cognitive abilities. The effect of maternal cessation of smoking before pregnancy on child's cognitive development is less clear.Aims: To study whether maternal cessation of smoking before pregnancy is associated with children's cognitive abilities.Study design and subjects: The original cohort included all 1535 live-born infants admitted to the neonatal wards during 1year and 658 randomly recruited non-admitted infants. The present study sample comprised 1019 (68.2%) children of the original sample born at term and free of any major impairment followed up to 56months.Outcome measures: Child's general reasoning, visual–motor integration, verbal competence, and langua... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722990 Mon, 18 Apr 2011 15:01:33 +0100 4722990 http://www.medworm.com/index.php?rid=4722989&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000831%2Fabstract%3Frss%3Dyes Abstract: Testosterone was assayed in the saliva of 32 female and 42 male 3–5month old infants, and the lengths of their finger segments between flexion creases were measured. While expected sex differences were identified in the finger measures, these sex differences were not correlated with salivary testosterone in either sex. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722989 Mon, 18 Apr 2011 15:01:33 +0100 4722989 http://www.medworm.com/index.php?rid=4722988&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000818%2Fabstract%3Frss%3Dyes Abstract: Background: Few cUS studies of cerebral measurements are available for normal term infants. Normative data is important for evaluating cerebral structure size in symptomatic term infants and assessing preterm brain growth by term age.Objectives: To (i) make linear measurements using cranial ultrasound (cUS) for major cerebral structures and intracranial spaces in normal newborn term infants, (ii) correlate these measurements with gestational age (GA), birth weight (BW), head circumference (HC), gender and within one infant (iii) examine inter/intra-observer variation, and (iv) compare these data with those currently available.Design, setting and patients: Linear cUS measurements of major cerebral structures were made in well term-born Ugandan infants at Mulago University Hospital... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722988 Mon, 18 Apr 2011 15:01:33 +0100 4722988 http://www.medworm.com/index.php?rid=4722987&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000788%2Fabstract%3Frss%3Dyes Abstract: Aims: Hypoxic Ischaemic Encephalopathy (HIE) causes characteristic changes of the electroencephalogram (EEG), and a raised Nucleated Red Blood Cell (NRBC) count compared to controls. We wished to examine whether combining these markers could improve their ability to predict HIE severity in the first 24h.Methods: Term infants with HIE were recruited. NRBC count and continuous multi-channel EEG were recorded within the first 24h. Neurological assessment was carried out at 24months. A control population with NRBC counts in the first 24h was recruited.Results: 44 infants with HIE and 43 control infants were recruited. Of the HIE population 39 completed a 2year follow-up. The median NRBC count differed significantly between the controls and those with HIE (3/100 WBC [range of 0–11] ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722987 Mon, 18 Apr 2011 15:01:33 +0100 4722987 http://www.medworm.com/index.php?rid=4722986&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100079X%2Fabstract%3Frss%3Dyes Conclusions: OCT measurements show that intrautero exposure to tobacco smoke interferes with the development of the optic nerve. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722986 Mon, 18 Apr 2011 15:01:32 +0100 4722986 http://www.medworm.com/index.php?rid=4722985&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000806%2Fabstract%3Frss%3Dyes Abstract: Background: To evaluate if concentrations of inflammation-related proteins were elevated in early postnatal blood specimens of preterm newborns who two years later had a small head.Methods: We measured 25 proteins in blood collected on days 1, 7, and 14 from 839 infants born before the 28th week of gestation and whose head circumference was measured at birth and near 24-months post-term equivalent. We excluded children whose birth head circumference was at or below the third centile. A protein concentration was considered elevated if it was in the highest quartile for gestational age and the day the specimen was obtained.Findings: When proteins were evaluated individually, elevated concentrations of SAA on day 1 and five proteins on day 14, IL-6, TNF-R2, IL-8, MCP-1, and ICAM-1 w... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722985 Mon, 18 Apr 2011 15:01:32 +0100 4722985 http://www.medworm.com/index.php?rid=4722984&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211001551%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4722984 Mon, 18 Apr 2011 15:01:32 +0100 4722984 http://www.medworm.com/index.php?rid=4641778&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000727%2Fabstract%3Frss%3Dyes Abstract: Late preterm infants are a vulnerable population susceptible to early breastfeeding failure and lactation-associated morbidities. We have found that late preterm gestation has a negative effect on mothers' psychological profiles in the puerperium, with the resulting levels of anxiety, depression, and psychological distress correlating negatively with their early lactation performance. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641778 Mon, 28 Mar 2011 17:10:55 +0100 4641778 http://www.medworm.com/index.php?rid=4641777&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000776%2Fabstract%3Frss%3Dyes Conclusions: Elevated NRBCs and FTV were associated with higher illness severity during the first 24h after birth in preterm infants. Ascending intrauterine infection was not associated with high illness severity. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641777 Mon, 28 Mar 2011 17:10:54 +0100 4641777 http://www.medworm.com/index.php?rid=4641776&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000740%2Fabstract%3Frss%3Dyes Conclusions: First evidence is provided for an early nutritional origin in excessive infant crying. A low maternal vitamin B-12 status during pregnancy could, in theory, affect infant crying behavior through two potential mechanisms: the methionine–homocysteine metabolism and/or the maturation of the sleep–wake rhythm. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641776 Mon, 28 Mar 2011 17:10:54 +0100 4641776 http://www.medworm.com/index.php?rid=4641775&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000715%2Fabstract%3Frss%3Dyes The objective of the study is to determine whether the qualitative assessment of fidgety movements will predict the neurological outcome of very low birth weight and extremely low birth weight infants admitted to Tygerberg Children's Hospital (TCH), Cape Town, South Africa.Methodology: A prospective descriptive study was conducted using Prechtl's method of qualitative assessment of fidgety movements at three months corrected age (CA). The study sample consisted of 115 infants, with a birth weight of ≤1250g each. At 12months CA, the infants' final motor outcome was classified as normal, abnormal or suspect according to assessments undertaken in line with those of Amiel-Tison and Gosselin, the Peabody Developmental Motor Scale and the Alberta Infant Motor Scale (AIMS).Results: A significan... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641775 Mon, 28 Mar 2011 17:10:54 +0100 4641775 http://www.medworm.com/index.php?rid=4641774&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000703%2Fabstract%3Frss%3Dyes Abstract: Aim: To study the predictive value of a developmental assessment at 2years corrected age (CA) for schooling at age 8 in children born very preterm and free of disability or delay; to identify other factors associated with schooling in this population.Methods: 244 children born before 33weeks in 1997, part of the population-based EPIPAGE cohort study, free of disability or delay, had their developmental quotient (DQ) evaluated with the Brunet-Lezine scale at 2years CA. The mental processing composite (MPC) score was evaluated at age 5 with the K-ABC battery. Data on schooling were obtained at age 8 by postal questionnaire. Schooling was considered appropriate if the child was attending age-appropriate grade level in a regular classroom environment without support at school.Results... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641774 Mon, 28 Mar 2011 17:10:54 +0100 4641774 http://www.medworm.com/index.php?rid=4641773&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000697%2Fabstract%3Frss%3Dyes Conclusions: The mainly blind subjects managed to overcome Fraiberg's “conceptual problem” — i.e., they acquired the ability to attribute an external object with identity and substance even when it manifested its presence through sound only — and thus developed the ability to reach an object presented through sound. Instead, most of the blind children with multiple disabilities presented poor performances on the “reach on sound” protocol and were unable, before 36months of age, to develop the strategies needed to resolve Fraiberg's “conceptual problem”. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641773 Mon, 28 Mar 2011 17:10:54 +0100 4641773 http://www.medworm.com/index.php?rid=4641772&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000685%2Fabstract%3Frss%3Dyes Conclusion: New mothers need to express their feelings about their babies, as hospital staff observation of mother–infant interactions is not sufficiently reliable for assessing the attachment process. The self-report MIBS is a useful tool for detecting difficulties in early mother–infant bonding. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641772 Mon, 28 Mar 2011 17:10:54 +0100 4641772 http://www.medworm.com/index.php?rid=4641771&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000673%2Fabstract%3Frss%3Dyes Abstract: Background: Higher parenting stress in mothers of children born very preterm may be in part a response to poorer neurobehavioral development, reflecting realistic concerns in addition to adaptation to the trauma of preterm delivery. To our knowledge, there are few longitudinal studies of parenting stress that have addressed child cognitive competence.Aims: To examine parenting stress in preterm and full-term children at 8 and 18months corrected chronological age (CCA), in relation to child cognitive development and behavior.Subjects: Participants were N=152 children (98 preterm born ≤32weeks gestation, and 54 full-term) seen at 8 and 18months CCA, and the primary caregiver parent.Study design/Outcome measures: The Parenting Stress Index questionnaire was completed by a parent, ... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641771 Mon, 28 Mar 2011 17:10:53 +0100 4641771 http://www.medworm.com/index.php?rid=4641770&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000661%2Fabstract%3Frss%3Dyes Abstract: Language delay is a well documented problem that occurs on a higher rate in preterm children compared to full term children. Preverbal social skills, such as the ability to share attention to an object with another person (i.e., triadic interaction), are suggested to reflect part of the processes through which children learn language. This longitudinal study examined preverbal and verbal skills in 25 preterm and 35 full term children in order to investigate if birth status affects language development through the proposed mediating processes of preverbal dyadic and triadic skills. Dyadic initiatives during the still-face episode were assessed at 6months. Triadic responsiveness (gaze following) was examined at 9 and 14months. Triadic initiatives (joint attention and behavioral req... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641770 Mon, 28 Mar 2011 17:10:53 +0100 4641770 http://www.medworm.com/index.php?rid=4641769&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100065X%2Fabstract%3Frss%3Dyes Conclusions: Normalized low and normalized high frequency power of fetal heart rate variability is associated with fetal scalp blood pH. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641769 Mon, 28 Mar 2011 17:10:53 +0100 4641769 http://www.medworm.com/index.php?rid=4641768&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000594%2Fabstract%3Frss%3Dyes Abstract: Background: The role of chorioamnionitis in neurodevelopment of preterm infants is not fully understood.Aim: To examine the association between different indicators of intrauterine inflammation (clinical chorioamnionitis, histological chorioamnionitis and funisitis) and neurodevelopmental impairment in very preterm infants.Methods: Preterm infants with a birth weight of (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641768 Mon, 28 Mar 2011 17:10:53 +0100 4641768 http://www.medworm.com/index.php?rid=4641767&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000582%2Fabstract%3Frss%3Dyes Abstract: Background: Preterm children are at risk for behavior problems. Studies examining contributions of intellectual and environmental factors to behavior outcomes in preterm children are mixed.Aims: (1) To identify the nature of maladaptive behaviors in preterm children age 9 to 16years born across the spectrum of gestational age and birth weight (BW). (2) To examine contributions of BW as a biological factor, socioeconomic status as an environmental factor, and intelligence quotient (IQ) as indicative of intellectual ability to behavior outcomes.Method: Using the Child Behavior Checklist, parent reports of behavior for 63 preterm children (gestational age 24 to (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641767 Mon, 28 Mar 2011 17:10:53 +0100 4641767 http://www.medworm.com/index.php?rid=4641766&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000570%2Fabstract%3Frss%3Dyes Conclusions: This three-dimensional volumetric approach is a necessary complement to studies that are performed in the sagittal plane and are based on the identification of landmarks. The geometric morphometric method used by authors permitted to obtain original informations on the growth kinetics and bone tridimensional movements of the human fetal skull base. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641766 Mon, 28 Mar 2011 17:10:53 +0100 4641766 http://www.medworm.com/index.php?rid=4641765&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100137X%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4641765 Mon, 28 Mar 2011 17:10:53 +0100 4641765 http://www.medworm.com/index.php?rid=4590471&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000600%2Fabstract%3Frss%3Dyes Abstract: Background: The quality of spontaneous general movements (GMs), assessed in the individual infant, has emerged as one of the most reliable and valid predictors especially of severe neurological impairments.Aims: To implement a more detailed assessment of GMs and co-existing movements and postural patterns in a rehabilitation clinic, and to examine to what extend is the optimality of movements and postures of infants aged 3 to 5months related to perinatal events and the neurological outcome.Study design: Prospective study of 41 infants (15 boys and 26 girls; 11 infants born preterm) admitted to the Department of Paediatric Neurology and Rehabilitation of the St. Joseph's Hospital in Kyoto (Japan).Outcome measures: Clinical, neurological and psychological status at age 5.Results: M... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590471 Tue, 01 Mar 2011 00:00:00 +0100 4590471 http://www.medworm.com/index.php?rid=4590470&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000612%2Fabstract%3Frss%3Dyes Conclusions: These results suggest that dietary supplementation of DHA during the first year of life leads to enhanced cognitive development at 18months of age. DHA concentration of 0.32% is adequate to improve cognitive function; higher concentrations did not confer additional benefit. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590470 Tue, 01 Mar 2011 00:00:00 +0100 4590470 http://www.medworm.com/index.php?rid=4590469&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821000719X%2Fabstract%3Frss%3Dyes Conclusions: We demonstrated that the upper-margin amplitude of aEEG in infants with cPVL was significantly higher than that in the control infants at 6–13days after birth. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590469 Tue, 01 Mar 2011 00:00:00 +0100 4590469 http://www.medworm.com/index.php?rid=4590468&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007206%2Fabstract%3Frss%3Dyes Conclusions: The observation of similar anomalies of the autonomic nervous and the cardiac conduction systems in both unexplained perinatal deaths and SIDS indicates their common congenital nature. Therefore, the definitions of these deaths, currently nosographically distinct, should be unified. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590468 Tue, 01 Mar 2011 00:00:00 +0100 4590468 http://www.medworm.com/index.php?rid=4590467&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007218%2Fabstract%3Frss%3Dyes Abstract: Objective: To determine the better approach for weaning preterm infants from nasal continuous positive airway pressure (NCPAP) with or without transitioning to nasal cannula (NC).Design/methods: This is a randomized, open label, controlled trial. Preterm infants born at ≥28weeks gestation who were clinically stable on NCPAP of 5cm H2O with FiO2 (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590467 Tue, 01 Mar 2011 00:00:00 +0100 4590467 http://www.medworm.com/index.php?rid=4590466&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007188%2Fabstract%3Frss%3Dyes Conclusions: VAS dilated the foetal pupil. Sonographic assessment of the foetal pupil provided important insights in the development of foetal neurological functions. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590466 Tue, 01 Mar 2011 00:00:00 +0100 4590466 http://www.medworm.com/index.php?rid=4590465&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007164%2Fabstract%3Frss%3Dyes Abstract: Background: Studies have suggested that different non-glucose sugars and sugar alcohols play a role in placental and fetal metabolism. However, the role of fructose in the fetal and newborn metabolism is unclear and studies are scarce.Aim: Our objective was to investigate the presence of fructose in umbilical cord blood in full-term gestation and its relationship with maternal and 48-hour-old- newborn blood concentrations, to evaluate fructose production by the fetus and newborn infant.Methods: Blood fructose and glucose concentrations were determined by HPLC in 26 paired samples of maternal blood, umbilical cord vein, and peripheral newborn blood at 48h after birth. ANOVA, the Friedman Analysis of Variance on Ranks and the Pearson correlation with p (Source: Early Human Developm... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590465 Tue, 01 Mar 2011 00:00:00 +0100 4590465 http://www.medworm.com/index.php?rid=4590464&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007139%2Fabstract%3Frss%3Dyes Abstract: Background: Extremely low birth weight (ELBW) infants are at risk of cognitive impairment and follow-up is therefore of major importance. The age at which their neurodevelopmental outcome (NDO) can reliably be predicted differs in the literature.Aims: To describe NDO at 2, 3.5 and 5.5years in an ELBW cohort. To examine the value of NDO at 2years corrected age (CA) for prediction of NDO at 3.5 and 5.5years.Study design: A retrospective cross-sectional and longitudinal cohort study.Subjects: 101 children with a BW≤750g, born between 1996 and 2005, who survived NICU admission and were included in a follow-up program.Outcome measures: NDO, measured with different tests for general development and intelligence, depending on age of assessment and classified as normal (Z-score≥−1)... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590464 Tue, 01 Mar 2011 00:00:00 +0100 4590464 http://www.medworm.com/index.php?rid=4590463&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007140%2Fabstract%3Frss%3Dyes Abstract: Background: Several studies have reported the development of various aspects of visual function in infancy and early childhood in both preterm and term-born infants, but only a few studies have focused on the predictive power of neonatal visual findings in infants with brain lesions.Aims: To explore visual findings at term age, and at 3 and 12months corrected age in preterm infants (gestational age (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590463 Tue, 01 Mar 2011 00:00:00 +0100 4590463 http://www.medworm.com/index.php?rid=4590462&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007152%2Fabstract%3Frss%3Dyes This study aims to investigate the association between disparities in parental age and increased risk factor for common mental disorders in the progenies during adulthood.Methodology: The Malaysian Mental Health Survey (MMHS) was analysed for this study. Respondents were asked to estimate the age of their parents at their birth. Presence of common mental disorders (CMD) was determined by referring to the diagnosis given by the Clinical Interview Schedule-Revised (CIS-R) instrument in the Programmed Questionnaire System (PROQSY) format. The association between parental age disparities and CMD was studied using logistic regression.Result: Fifty three percent (n=1972) of the MMHS respondents (N=3666) knew the age of both parents and were included in the study. Three percent (n=53) had signifi... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590462 Tue, 01 Mar 2011 00:00:00 +0100 4590462 http://www.medworm.com/index.php?rid=4590461&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007176%2Fabstract%3Frss%3Dyes In conclusion, iron deficiency during pregnancy is related to the neonate's general autonomous response, motor performance and self regulation capabilities. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590461 Tue, 01 Mar 2011 00:00:00 +0100 4590461 http://www.medworm.com/index.php?rid=4590460&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007127%2Fabstract%3Frss%3Dyes Abstract: Stress in early life negatively influences growth quality through perturbations in body composition including increased fat mass. At term (40weeks) preterm infants have greater fat mass and abdominal visceral adipose tissue than term-born infants. Mechanical-tactile stimulation (MTS) attenuates the stress response in preterm infants and rodents. We tested the hypothesis that MTS, administered during an established model of neonatal stress, would decrease stress-driven adiposity and prevent associated metabolic imbalances in rat pups. Pups received one of three treatments from postnatal days 5 to P9: Neonatal Stress (Stress; n=20) = painful stimulus and hypoxic/hyperoxic challenge during 60min of maternal separation; MTS (n=20) = neonatal stress+10min of MTS; or Control (n=20). Bo... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590460 Tue, 01 Mar 2011 00:00:00 +0100 4590460 http://www.medworm.com/index.php?rid=4590459&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007097%2Fabstract%3Frss%3Dyes Conclusions: Earlier SSC beginning within 5min post birth and longer SSC continuing for more than 60min within 120min post birth are beneficial for stability of cardiopulmonary dynamics and the reduction of infant stress during the early period post birth. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590459 Tue, 01 Mar 2011 00:00:00 +0100 4590459 http://www.medworm.com/index.php?rid=4590458&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378211000855%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4590458 Tue, 01 Mar 2011 00:00:00 +0100 4590458 http://www.medworm.com/index.php?rid=4404990&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006912%2Fabstract%3Frss%3Dyes Abstract: A sub-analysis was conducted of data from a study of prolonged use of sucrose for hospitalized infants (N=50 infants) during heel lancing. Results showed that pain responses differed when opioid analgesics were administered concomitantly with sucrose (n=79 pain assessments), than when sucrose was administered alone (n=364 pain assessments). (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404990 Thu, 27 Jan 2011 23:18:24 +0100 4404990 http://www.medworm.com/index.php?rid=4404989&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006870%2Fabstract%3Frss%3Dyes Abstract: We measured circulating ADMA concentrations in a group of very premature newborns at birth and during the first week of life.ADMA levels resulted significantly higher in infants born to mothers with histologic chorioamnionitis than in infants delivered for other maternal or fetal indications, both at birth and through the first week of life.We speculate that ADMA might be involved in the complex biological events associated with fetal exposure to chorioamnionitis. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404989 Thu, 27 Jan 2011 23:18:24 +0100 4404989 http://www.medworm.com/index.php?rid=4404988&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007103%2Fabstract%3Frss%3Dyes Conclusions: Six-year-old VLBW children even with normal early development are still at risk of deficits in “planning”, “cognitive flexibility” and “nonverbal working memory” while the preterm factors, both gestation age and birth weight, were important covariant factors. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404988 Thu, 27 Jan 2011 23:18:24 +0100 4404988 http://www.medworm.com/index.php?rid=4404987&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210007115%2Fabstract%3Frss%3Dyes Conclusions: These data add a new specific aspect to the ‘fetal programming hypothesis’ and are the first to confirm the speculative data from retrospective studies. Baseline cortisol does not seem to be the ‘hormonal mediator’ of this association. Therefore, cortisol stress reactivity or other neuroendocrine mechanisms should be assessed in future studies. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404987 Thu, 27 Jan 2011 23:18:23 +0100 4404987 http://www.medworm.com/index.php?rid=4404986&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006948%2Fabstract%3Frss%3Dyes Conclusions: This study indicates that the fetus might participate in maternal relaxation and suggests that GI is superior to PMR. This could especially be true for women who tend to direct their attention to body sensations such as abdominal activity. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404986 Thu, 27 Jan 2011 23:18:22 +0100 4404986 http://www.medworm.com/index.php?rid=4404985&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006936%2Fabstract%3Frss%3Dyes Conclusions: Finding greater risk of cognitive deficit in those NICU-admitted due to clinical instability or birth weight (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404985 Thu, 27 Jan 2011 23:18:22 +0100 4404985 http://www.medworm.com/index.php?rid=4404984&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006900%2Fabstract%3Frss%3Dyes Abstract: Aim: The effect of selective head cooling on cerebral blood flow (CBF) and cerebral metabolism rate (CMR) was investigated in newborn piglets.Methods: Seven days old newborn piglets were randomly assigned to one of the following three groups: Selective head cooling in normal piglets (n=4), selective head cooling after HI (n=6) and normal temperature after HI (n=6). CBF was measured with color microspheres. Cerebral oxygenation metabolism rate (CMRO2), Cerebral glucose consumption (CMRGlu) and Cerebral lactate production (CMRlac) were calculated.Result: In normal piglets, CBF, CMRO2 and CMRglu were significantly decreased at both 35°C (P (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404984 Thu, 27 Jan 2011 23:18:22 +0100 4404984 http://www.medworm.com/index.php?rid=4404983&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006882%2Fabstract%3Frss%3Dyes Conclusions: The co-occurrence of TORCH congenital infection in infants with SGA is rare. Routine TORCH screening in neonates with isolated SGA does not seem warranted and should be limited to CMV urine cultures. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404983 Thu, 27 Jan 2011 23:18:21 +0100 4404983 http://www.medworm.com/index.php?rid=4404982&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006894%2Fabstract%3Frss%3Dyes Conclusion: Our findings suggest that genetically determined differences in cortisol exposure affect cardiovascular development in early life. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404982 Thu, 27 Jan 2011 23:18:21 +0100 4404982 http://www.medworm.com/index.php?rid=4404981&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006924%2Fabstract%3Frss%3Dyes Conclusion: AERP alterations suggest that perinatal cerebral insults affect cortical auditory processing. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404981 Thu, 27 Jan 2011 23:18:20 +0100 4404981 http://www.medworm.com/index.php?rid=4404980&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006754%2Fabstract%3Frss%3Dyes Conclusions: Mortality rate is low in patients with fetal SVT and AF but high in patients with AVB. Related morbidity includes WPW-syndrome and congenital cardiac anomalies. Electrocardiographic screening is recommended in all fetal SVT cases before adolescence since WPW-syndrome may occur later in life. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404980 Thu, 27 Jan 2011 23:18:20 +0100 4404980 http://www.medworm.com/index.php?rid=4404979&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006766%2Fabstract%3Frss%3Dyes Abstract: Background: The umbilical cord and vitelline duct are of vital importance to the fetus, but they are rarely the subject of first trimester two-dimensional (2D) ultrasound evaluation due to the complexity of their shape and morphology. Virtual reality (VR) allows efficient visualisation and measurement of complex structures like the umbilical cord and vitelline duct.Aim: To measure normal first trimester human growth of the umbilical cord length (UCL) and vitelline duct length (VDL) using a VR system; and to correlate both measurements with the gestational age (GA) and crown-rump length (CRL) and the VDL with the yolk sac volume (YSV).Study design: Prospective cohort study. Serial three-dimensional (3D) ultrasound measurements were performed from six to 14weeks GA, resulting in 12... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404979 Thu, 27 Jan 2011 23:18:19 +0100 4404979 http://www.medworm.com/index.php?rid=4404978&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821000232X%2Fabstract%3Frss%3Dyes Abstract: Introduction: Intrauterine growth restriction (IUGR) is a significant cause of both short- and long-term morbidity and mortality. IUGR secondary to placental dysfunction is correlated with telomere shortening. Telomerase is an enzyme complex that elongates telomeres. One of its components is encoded by the telomerase RNA component gene (TERC), which serves as the RNA template for the addition of telomeric repeats. We hypothesized decreased TERC gene copy number in IUGR placentas as part of the mechanism of telomere shortening in placental dysfunction.Methods: We estimated the gene copy number of the TERC gene at 3q26 by applying FISH to trophoblasts of placental biopsies from five pregnancies with IUGR caused by placental insufficiency and compared them to placentas from five ges... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404978 Thu, 27 Jan 2011 23:18:19 +0100 4404978 http://www.medworm.com/index.php?rid=4404977&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006869%2Fabstract%3Frss%3Dyes Abstract: Newborn infants, especially preterm infants, have an immature immune system, which is not capable to actively protect against vaccine-preventable infections. Therefore, the newborn is dependent on transplacental transport of Immunoglobulin G (IgG), an active, FcRn receptor mediated process. Fetal IgG rises from approximately 10% of the maternal concentration at 17–22weeks of gestation to 50% at 28–32weeks of gestation. If transplacental acquired IgG is lower in preterm than in term infants, preterm infants are especially at risk for these vaccine-preventable diseases.The aim of this study was to review the transplacental transfer of IgG against vaccine-preventable diseases (measles, rubella, varicella-zoster, mumps, Haemophilus influenza type B, diphtheria, tetanus, pertussis... Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404977 Thu, 27 Jan 2011 23:18:18 +0100 4404977 http://www.medworm.com/index.php?rid=4404976&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS037837821100003X%2Fabstract%3Frss%3Dyes (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4404976 Thu, 27 Jan 2011 23:18:18 +0100 4404976 http://www.medworm.com/index.php?rid=4293137&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006729%2Fabstract%3Frss%3Dyes Conclusions: Preterm preschoolers with average cognition capability are at risk of defect in visual–spatial perception, especially when they are confronted with more complicated information. PRVEP may provide an objective and convenient measurement in detecting the problem of visual perception in children. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4293137 Wed, 29 Dec 2010 02:53:04 +0100 4293137 http://www.medworm.com/index.php?rid=4293136&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006730%2Fabstract%3Frss%3Dyes Conclusion: In view of the neurodevelopment of the infants, it seems that the most efficient obstetric strategy for improving prognosis of premature infants should be targeted to prolong the pregnancy period as long as the reassuring fetal status and maternal stable health condition are being confirmed. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4293136 Wed, 29 Dec 2010 02:53:03 +0100 4293136 http://www.medworm.com/index.php?rid=4293135&cid=s_35527_69_f&fid=35527&url=http%3A%2F%2Fwww.earlyhumandevelopment.com%2Farticle%2FPIIS0378378210006705%2Fabstract%3Frss%3Dyes Conclusions: Current care and treatment of pregnant women with type 1 diabetes result in cardiovascular and metabolic outcome in the offspring at 6–8years of age that is comparable to that in children of non-diabetic women. Further follow-up should substantiate these results at later age. (Source: Early Human Development) Early Human Development journals http://www.medworm.com/rss/comments.php?id=4293135 Wed, 29 Dec 2010 02:53:03 +0100 4293135