MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Endocrine' source. Wed, 08 Feb 2012 15:08:55 +0100 http://www.medworm.com/index.php?rid=5667747&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcmu3728q7874x475%2F The objective of this study is to identify the genetic defects in a Chinese family with autosomal dominant familial neurohypophyseal diabetes insipidus. Complete physical examination, fluid deprivation, and DDAVP tests were performed in three affected and three healthy members of the family. Genomic DNA was extracted from leukocytes of venous blood of these individuals for polymerase chain reaction amplification and direct sequencing of all three coding exons of arginine vasopressin–neurophysin II (AVP–NPII) gene. Seven members of this family were suspected to have symptomatic vasopressin-deficient diabetes insipidus. The water deprivation test in all the patients confirmed the diagnosis of vasopressin-deficient diabetes insipidus, with the pedigree demonstrating an autosomal domi... Endocrine journals http://www.medworm.com/rss/comments.php?id=5667747 Fri, 03 Feb 2012 17:11:41 +0100 5667747 http://www.medworm.com/index.php?rid=5667748&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fev477761314k753w%2F Abstract  Both stiffness and strength of bones are thought to be controlled by the “bone mechanostat”. Its natural stimuli would be the strains of bone tissue (sensed by osteocytes) that are induced by both gravitational forces (body weight) and contraction of regional muscles. Body weight and muscle mass increase with age. Biomechanical performance of load-bearing bones must adapt to these growth-induced changes. Hypophysectomy in the rat slows the rate of body growth. With time, a great difference in body size is established between a hypophysectomized rat and its age-matched control, which makes it difficult to establish the real effect of pituitary ablation on bone biomechanics. The purpose of the present investigation was to compare mid-shaft femoral mechanical pro... Endocrine journals http://www.medworm.com/rss/comments.php?id=5667748 Fri, 03 Feb 2012 07:21:23 +0100 5667748 http://www.medworm.com/index.php?rid=5667749&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd685770367050345%2F Abstract  RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the steroidal regulation of uterine RECK is lacking. To address this gap in our knowledge, we examined steroidal regulation and cellular expression of Reck mRNA and protein within the mouse uterus in vivo. Uterine Reck mRNA and protein were decreased by estrogen, while progesterone alone had no effect. The estrogen-induced down regulation could be partially blocked by progesterone. RECK was localized primarily to luminal and glandular epithelial cells and the ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5667749 Thu, 02 Feb 2012 18:15:13 +0100 5667749 http://www.medworm.com/index.php?rid=5667750&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F42h7847pt0566553%2F Abstract  The serum aldosterone concentration (SAC)/plasma renin activity (PRA) ratio (ARR) is considered a useful screening test in the differential diagnosis of essential hypertension (EH) and primary aldosteronism (PA). The purpose of this study is to investigate the effect of age on ARR and compare the screening accuracy of ARR plus elevated SAC for PA screening in different age groups. Thirty-nine patients with PA, 274 patients with EH, and 153 healthy volunteers were recruited. Blood was sampled for SAC and PRA measuring under keeping upright posture for 1 h. Levels of SAC, PRA, and ARR were compared at different ages range for the respective three groups of subjects. The screening accuracy of ARR plus elevated SAC was compared in different age groups and PA pati... Endocrine journals http://www.medworm.com/rss/comments.php?id=5667750 Thu, 02 Feb 2012 18:15:12 +0100 5667750 http://www.medworm.com/index.php?rid=5660416&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc77j2rp648480608%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-012-9610-6Authors Shirin Hasani-Ranjbar, Endocrinology and Metabolism Research Institute, Shariati Hospital, Tehran University of Medical Sciences, 5th Floor, North Kargar Ave, 14114 Tehran, IranMahsa M. Amoli, Endocrinology and Metabolism Research Institute, Shariati Hospital, Tehran University of Medical Sciences, 5th Floor, North Kargar Ave, 14114 Tehran, Iran Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5660416 Tue, 31 Jan 2012 07:10:33 +0100 5660416 http://www.medworm.com/index.php?rid=5660417&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk17g307xn7898678%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-012-9615-1Authors Antonia García-Martín, Bone Metabolic Unit, Endocrinology Division, Hospital Universitario San Cecilio, Av. Dr. Olóriz 16, 18012 Granada, SpainRebeca Reyes-García, Bone Metabolic Unit, Endocrinology Division, Hospital Universitario San Cecilio, Av. Dr. Olóriz 16, 18012 Granada, SpainMariela Varsavsky, Bone Metabolic Unit, Endocrinology Division, Hospital Universitario San Cecilio, Av. Dr. Olóriz 16, 18012 Granada, SpainManuel Muñoz-Torres, Bone Metabolic Unit, Endocrinology Division, Hospital Universitario San Cecilio, Av. Dr. Olóriz 16, 18012 Granada, Spain Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5660417 Tue, 31 Jan 2012 07:10:32 +0100 5660417 http://www.medworm.com/index.php?rid=5648821&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F88404871t13013q0%2F Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s12020-012-9608-0Authors Marcello D. Bronstein, Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, SP, Brazil Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5648821 Sat, 28 Jan 2012 16:52:20 +0100 5648821 http://www.medworm.com/index.php?rid=5638943&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk695t2352h501115%2F Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s12020-012-9607-1Authors Maria Laura Tanda, Department of Clinical & Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Viale Borri, 57, 21100 Varese, ItalyEliana Piantanida, Department of Clinical & Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Viale Borri, 57, 21100 Varese, ItalyLuigi Bartalena, Department of Clinical & Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, Viale Borri, 57, 21100 Varese, Italy Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5638943 Tue, 24 Jan 2012 12:27:10 +0100 5638943 http://www.medworm.com/index.php?rid=5638945&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61h8244548274551%2F Abstract  Adiponectin gene polymorphisms have been implicated in polycystic ovary syndrome (PCOS) development. However, results from previous studies were inconsistent and inconclusive. To shed some light on the relationship of two adiponectin gene polymorphisms, T45G and G276T, with PCOS, we conducted the current meta-analysis. PubMed was used for searching all eligible studies up to September 30, 2011. Odds ratio (OR) with the corresponding 95% confidence interval (CI) was adopted to evaluate the strength of the associations. In total, ten case–control studies involving 2,821 participants were included in the meta-analysis. Results showed that the T45G polymorphism was not associated with PCOS for allelic contrast (OR = 1.10, 95%CI: 0.83–1.44, P = 0... Endocrine journals http://www.medworm.com/rss/comments.php?id=5638945 Tue, 24 Jan 2012 07:35:26 +0100 5638945 http://www.medworm.com/index.php?rid=5638944&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe65414jhg27872pq%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s12020-012-9592-4Authors Ezio Ghigo, Department of Medicine, University of Turin, Turin, Italy Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5638944 Tue, 24 Jan 2012 07:35:26 +0100 5638944 http://www.medworm.com/index.php?rid=5638946&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm736528764180g1v%2F Abstract  The purpose of this article is to evaluate the variability and reproducibility of late night salivary cortisol (LNSC) using electrochemiluminescence immunoassay (ECLIA) and compare the accuracy of one or two samples in diagnosis of Cushing’s syndrome (CS). We prospectively included 64 healthy volunteers (HV), 35 patients with clinically suspected CS (S), and 26 patients with confirmed CS. Nine patients in the CS group had 24-h urinary free cortisol (UFC) less than two times the upper limit of normal (mild CS). UFC and two consecutive LNSC (LNSC1, LNSC2) were collected at home. All patients in the S group had normal UFC and low-dose dexamethasone suppression test. No differences were found between the HV and S groups in UFC, LNSC1, and LNSC2. Intra-individual var... Endocrine journals http://www.medworm.com/rss/comments.php?id=5638946 Tue, 24 Jan 2012 07:35:25 +0100 5638946 http://www.medworm.com/index.php?rid=5620677&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb122x128t636rh45%2F Abstract  Thyroid hormones increase energy expenditure and bone turnover in vivo. To study whether 3,3′,5-triiodo-l-thyronine (T3) stimulates the uptake of glucose in osteoblastic cells, PyMS (a cell line derived from rat bone) cells were kept in serum-free culture medium and treated with T3. We measured [1-14C]-2-deoxy-d-glucose (2DG) uptake and looked for expression of the high-affinity glucose transporters GLUT1 and GLUT3 by northern and western analysis. T3 did not influence the cell number but slightly (1.3-fold) increased the protein content of the cell cultures. 2DG uptake was low in serum-deprived cell cultures and was increased by T3 (up to 2.5-fold at 1 nmol l−1 after 4 days) in a dose- and time-dependent manner. Triiodothyronine at 1 nmol&nbs... Endocrine journals http://www.medworm.com/rss/comments.php?id=5620677 Thu, 19 Jan 2012 07:01:10 +0100 5620677 http://www.medworm.com/index.php?rid=5620678&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg615228rv8p58748%2F The objectives of this study is to evaluate the efficacy and safety of alogliptin versus very low fat/calorie traditional Japanese diet (non-inferiority trial) as an initial therapy for newly diagnosed, drug naïve subjects with type 2 diabetes (T2DM). Study design was prospective, randomized, non-double-blind, controlled trial. The study was conducted at outpatient units of municipal hospital. Patients were newly diagnosed, drug naïve patients who visited the outpatient units. The patients randomly received 12.5–25 mg/day alogliptin (n = 25) or severe low calorie traditional Japanese diet (n = 26). The procedure of this trial was assessed by the consolidated standards of reporting trials statement. The primary end point was the change of HbA1c at 3 mo... Endocrine journals http://www.medworm.com/rss/comments.php?id=5620678 Tue, 17 Jan 2012 07:11:28 +0100 5620678 http://www.medworm.com/index.php?rid=5620679&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F004g21261191l104%2F Abstract  Corticotropin-releasing hormone (CRH) has been implicated to be involved in the development of dendrites in brain. In the present study, we examined the effect of CRH on dendrite outgrowth in primary cultured hippocampal neurons and defined the specific CRH receptor subtype involved. Treatment of neurons with increasing concentration of CRH resulted in an increase in the total dendritic branch length (TDBL) of neurons compared with untreated neurons over 2–4 days period of treatment. These effects can be reversed by the specific CRH-R1 antagonist antalarmin but not by the CRH-R2 antagonist astressin 2B. Treatment of neurons with urocortin II, the exclusive CRH-R2 agonist, significantly decreased TDBL of the cultured neurons. These effects can be reversed by... Endocrine journals http://www.medworm.com/rss/comments.php?id=5620679 Tue, 17 Jan 2012 07:11:25 +0100 5620679 http://www.medworm.com/index.php?rid=5609636&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F96t5v36061135638%2F Abstract  Inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) is considered as a major predictor of cardiovascular events. Apolipoprotein B (ApoB) directly reflects the number of plasma atherogenic lipoproteins, and may play a major role in vascular inflammation. We aimed to assess whether an association between ApoB and hsCRP exists and, furthermore, to examine whether ApoB is more predictive of the inflammatory status than other cardiovascular risk factors. This was a cross-sectional study, with 511 apparently healthy adult subjects enrolled. Waist circumference (WC), body mass index (BMI), and blood pressure (BP) were measured. Plasma glucose levels, hsCRP, lipid profile, and insulin were collected after 10–14 h fasting. From the lowest to the highe... Endocrine journals http://www.medworm.com/rss/comments.php?id=5609636 Sat, 14 Jan 2012 16:41:31 +0100 5609636 http://www.medworm.com/index.php?rid=5609637&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg5j40060g7371214%2F Abstract  It has been suggested that association between hypothyroidism with dyslipidemia might be present already at the stage of normal thyroid function through altered insulin sensitivity. We analyzed the role of insulin sensitivity as a mediator of thyroid-induced lipid changes in euthyroid type 1 diabetic patients. Study included 304 patients with type 1 diabetes and normal thyroid function. Insulin sensitivity was measured with estimated glucose disposal rate calculated using the equation: eGDR = 24.31 − (12.22 × WHR) − (3.29 × HT) − (0.57 × HbA1c); WHR = waist-to-hip ratio, HT = hypertension. TSH, FT4, FT3, and serum lipids were measured. Correlations and multiple linear ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5609637 Sat, 14 Jan 2012 16:41:30 +0100 5609637 http://www.medworm.com/index.php?rid=5609638&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7w45152514372643%2F Content Type Journal ArticleCategory Research LetterPages 1-3DOI 10.1007/s12020-012-9604-4Authors Rafael Timon, Department of Physical Education and Sport, Sport Science Faculty, University of Extremadura, Av de la Universidad s/n, 10003 Cáceres, SpainGuillermo Olcina, Department of Physical Education and Sport, Sport Science Faculty, University of Extremadura, Av de la Universidad s/n, 10003 Cáceres, SpainPablo Tomas-Carus, Department of Sport and Health, University of Evora, Evora, PortugalArmando Raimundo, Department of Sport and Health, University of Evora, Evora, PortugalJuan I. Maynar, Department of Analytical Chemistry, School of Sciences, University of Extremadura, Badajoz, SpainMarcos Maynar, Department of Physiology, Sport Science Faculty, University of Extremadura, Cácere... Endocrine journals http://www.medworm.com/rss/comments.php?id=5609638 Sat, 14 Jan 2012 16:41:27 +0100 5609638 http://www.medworm.com/index.php?rid=5609639&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw00287w650731836%2F Abstract  Obstructive sleep apnea (OSA) and 25-hydroxyvitamin-D3 (25-OH-D) deficiency are two separate disorders associating with obesity, inflammation, and impaired glucose metabolism. We aimed to investigate the vitamin D status of OSA patients regarding to potential links between lower vitamin D levels and abnormal glucose metabolism, which is one of the main adverse outcomes of OSA. Study group is composed of 190 non-diabetic subjects who were suspected of having OSA. Subjects undergone polysomnography and were grouped due to apnea−hypopnea indices (AHI) as controls (AHI < 5, n = 47), mild OSA (5 ≤ AHI < 15, n = 46), moderate OSA (15 ≤ AHI < 30, n = 47), and severe OSA (AHI&nbsp... Endocrine journals http://www.medworm.com/rss/comments.php?id=5609639 Sat, 14 Jan 2012 06:55:32 +0100 5609639 http://www.medworm.com/index.php?rid=5598402&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc00k85507346u570%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-012-9602-6Authors Ewa Matuszczak, Medical University of Bialystok, Białystok, PolandAdam Hermanowicz, Medical University of Bialystok, Białystok, PolandWojciech Debek, Medical University of Bialystok, Białystok, Poland Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5598402 Fri, 13 Jan 2012 16:50:54 +0100 5598402 http://www.medworm.com/index.php?rid=5598403&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpqj36628532k5723%2F In this study, we analyzed the effects of thalidomide on adipogenesis and found that adipocyte differentiation from preadipocytes in the orbital region was enhanced, which was demonstrated by enhanced expression of peroxisome proliferator activated receptor γ (PPARγ), ap2, and thyroid-stimulating hormone receptor (TSHR). The expression of inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin 6 (IL-6) was also increased in GO. Thalidomide dose-dependently inhibited adipogenesis of 3T3-L1 preadipocytes and orbital fibroblasts from GO patients. Along with the inhibited adipogenesis, the expression of TSHR, TNFα, and IL-6 was also down-regulated. We discovered that the mechanism for thalidomide inhibiting adipogenesis was the down-regulation of PPARγ, rather than C/... Endocrine journals http://www.medworm.com/rss/comments.php?id=5598403 Wed, 11 Jan 2012 17:53:03 +0100 5598403 http://www.medworm.com/index.php?rid=5598404&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx52tv15082418580%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-012-9601-7Authors Shoujiang Huang, Children’s Hospital Zhejiang University School of Medicine, Hangzhou, ChinaJinfa Tou, Children’s Hospital Zhejiang University School of Medicine, Hangzhou, China Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5598404 Tue, 10 Jan 2012 16:49:30 +0100 5598404 http://www.medworm.com/index.php?rid=5572592&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft554776r3l332102%2F Abstract  Congenital adrenal hyperplasia (CAH) is a group of disorders affecting adrenal steroid synthesis. The most common form, 21-hydroxylase deficiency, leads to decreased production of cortisol and aldosterone with increased androgen secretion. In classic CAH glucocorticoid treatment can be life-saving, and provides symptom control, but must be given in an unphysiological manner with the risk of negative long-term outcomes. A late diagnosis or a severe phenotype or genotype has also a negative impact. These factors can result in impaired quality of life (QoL), increased cardiometabolic risk, short stature, osteoporosis and fractures, benign tumors, decreased fertility, and vocal problems. The prognosis has improved during the last decades, thanks to better clinical man... Endocrine journals http://www.medworm.com/rss/comments.php?id=5572592 Fri, 06 Jan 2012 16:44:53 +0100 5572592 http://www.medworm.com/index.php?rid=5572591&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4263462174054644%2F Abstract  The purpose of this study was to determine low-grade inflammation associated with obesity that is mediated partially by TNF-α, an adipocytokine which stimulates sphingomyelinase activity in adipocytes. Circulating ceramide (Cer) and sphingosine 1-phosphate (S1P) are elevated in genetically obese (ob/ob) mice. We aimed to determine whether serum sphingolipid concentrations correlate with measures of obesity, insulin resistance, and lipid profiles in overweight versus lean adolescents. This cross-sectional study recruited 30 healthy overweight (body mass index, BMI ≥ 85%) and 15 lean (BMI 10–84%) adolescents. Anthropometric measurements and fasting blood samples were collected at one clinic visit. Serum glucose, insulin, and fasting lipid profiles were... Endocrine journals http://www.medworm.com/rss/comments.php?id=5572591 Fri, 06 Jan 2012 16:44:53 +0100 5572591 http://www.medworm.com/index.php?rid=5560779&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp330886u64466876%2F Abstract  This research aimed to analyze the clinical data of various etiologies of hypertension in patients hospitalized in the Endocrinology Division. The differences between essential and secondary hypertension were examined to provide a basis for clinical differential diagnosis. The data from all the inpatients with hypertension of unknown origin admitted in the Endocrinology Division of the First Affiliated Hospital of the Zhejiang University School of Medicine from January 2001 to May 2011 were reviewed. The patients were classified into either essential or secondary hypertensive groups. The differentiating parameters of these forms of hypertension were analyzed using the one-factor and multi-factor logistic regression analysis. A total of 1,001 cases were selected in... Endocrine journals http://www.medworm.com/rss/comments.php?id=5560779 Mon, 02 Jan 2012 16:47:51 +0100 5560779 http://www.medworm.com/index.php?rid=5560778&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F00j6t323m224xm47%2F Abstract  To investigate the adrenal effect of a phytosterol (PS) additive, 80 male Japanese quail were divided into four sub-groups and fed 0, 40, 400, and 4,000 ppm of PS, respectively, for 21 days. Subsequently, 50% of the birds from each dosage group were subjected to a 6-day adrenal function test, whereby they were injected with long-lasting adrenocorticotropin (ACTH). The remaining quail in each PS dosage group were raised under normal conditions. The groups receiving 400 and 4000 ppm PS exhibited decreased serum levels of LDL-cholesterol with and without ACTH stimulation (P < 0.01). No amount of dose of PS changed serum corticosterone (CORT) under normal conditions (P > 0.05). Enhancement of CORT was observed on the 2nd and the ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5560778 Mon, 02 Jan 2012 16:47:51 +0100 5560778 http://www.medworm.com/index.php?rid=5560780&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F07p653425731245h%2F Abstract  Type 1 (D1) and 2 (D2) iodothyronine deiodinases are selenocysteine-containing enzymes that catalyze the deiodination of T4 to T3 in the thyroid and in peripheral tissues. Despite their importance to the plasma T3 pool in human beings, there are few studies about their behavior in human thyroids. In order to better understand iodothyronine deiodinase regulation in the thyroid gland, we studied thyroid tissue samples from follicular adenoma (AD, n = 5), toxic diffuse goiter (TDG, n = 6), nontoxic multinodular goiter (NMG, n = 40), papillary thyroid carcinoma (PTC, n = 8), and surrounding normal tissues (NT, n = 7) from 36 patients submitted to elective thyroidectomy. D1 and D2 activities were determined by quantificati... Endocrine journals http://www.medworm.com/rss/comments.php?id=5560780 Fri, 30 Dec 2011 06:49:40 +0100 5560780 http://www.medworm.com/index.php?rid=5552794&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh978088657555w16%2F Abstract  To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 ± 8.3 vs. 9.6 ± 5.9 ng/ml, P = 0.001) and nesfatin-1 levels were found lower (5.5 ± 8.1 vs. 8.1 ± 23.9 ng/ml, P = 0.001)... Endocrine journals http://www.medworm.com/rss/comments.php?id=5552794 Tue, 27 Dec 2011 17:00:57 +0100 5552794 http://www.medworm.com/index.php?rid=5552795&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk860k36105h87250%2F In this study, we therefore aimed to evaluate whether a well-established cardiovascular risk factor, the Apolipoprotein E (Apo E) genotype, contributes to increased risk of cardiovascular complications in subjects with acromegaly. A total of 102 unrelated acromegaly subjects were prospectively included into this case–control association study and constituted our study group. The study group was comparable by age and gender with 200 unrelated healthy subjects constituting our control group. Genomic DNA was isolated from the peripheral blood leukocytes of all subjects and Apo E genotype (codon 112/158) was assessed by melting temperature analyses after using a real-time PCR protocol. The Apolipoprotein E4 allele was found at a significantly higher frequency in the study group when co... Endocrine journals http://www.medworm.com/rss/comments.php?id=5552795 Mon, 26 Dec 2011 16:47:09 +0100 5552795 http://www.medworm.com/index.php?rid=5544890&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyv3h307748441u02%2F Abstract  Age-related co-morbidities including osteoporosis are relevant in patients responding to combination antiretroviral therapy (cART). Vertebral fractures are common osteoporotic fractures and their diagnosis is useful for managing at-risk individuals. However, there are few data from HIV-infected patients. Therefore, the aim of this study was to determine the prevalence of and factors associated with vertebral fractures in a population of HIV-infected males. A cross-sectional study of 160 HIV-infected patients with available chest X-rays was conducted from 1998 to 2010. One hundred and sixty-three males with comparable age and with no history of HIV infection were recruited as controls. Semi-quantitative evaluation of vertebral heights in lateral chest X-rays and qu... Endocrine journals http://www.medworm.com/rss/comments.php?id=5544890 Sat, 24 Dec 2011 16:45:29 +0100 5544890 http://www.medworm.com/index.php?rid=5544891&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F41r2744227840m81%2F Abstract  Chronic obstructive pulmonary disease (COPD) is known to be a systemic inflammatory disease which affects the function of many organs, and the low bone mineral density (BMD) may be the result of systemic inflammation. The aim of the present study was to explore the association of BMD with systemic inflammation in patients with clinically stable COPD. BMD and inflammatory markers, including C-reactive protein, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), were determined in all the recruited patients with clinically stable COPD. The patients were classified according to T scores, and the relationship between BMD with markers of systemic inflammation and that with other osteoporosis risk factors was assessed. There were no differences in age, femal... Endocrine journals http://www.medworm.com/rss/comments.php?id=5544891 Fri, 23 Dec 2011 16:53:51 +0100 5544891 http://www.medworm.com/index.php?rid=5544892&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk372h4j5m87n168w%2F Abstract  The aim of this study is to investigate the associations between E-cadherin gene (CDH1) polymorphisms and papillary thyroid carcinoma (PTC) risk predisposition. We undertook a case–control study to analyze three CDH1 polymorphisms (+54T>C, −160C>A, and −347G→GA) in an Han Chinese population, by extraction of genomic DNA from the peripheral blood of 98 patients with PTC and 176 control participants, and performed CDH1 genotyping using DNA sequencing. The obtained results indicated that overall, no statistically significant association was observed in +54T>C. Nevertheless, −347G→GA genotype was at increased risk of PTC (P = 0.001; odds ratio (OR) = 2.12, CI 95%:1.24–3.34). Furthermore, −347GA/GA genotype thyroid cancers we... Endocrine journals http://www.medworm.com/rss/comments.php?id=5544892 Thu, 22 Dec 2011 12:51:14 +0100 5544892 http://www.medworm.com/index.php?rid=5538456&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn71374k140q255pj%2F Abstract  Hyperprolactinemia is the most common abnormality of the hypothalamic–pituitary axis. The aim of this study was to investigate the clinical and radiological features of patients with macroprolactinemia. The study population consisted of patients with elevated serum prolactin (PRL) concentrations who presented to our Endocrinology outpatient clinic. Detection of macroprolactin (macroPRL) was performed using the polyethylene glycol precipitation method. Patients in which macroPRL made up more than 60% of total PRL levels were stratified into the macroPRL group, while the remaining patients were placed in the monomeric prolactin (monoPRL) group. A total of 337 patients were enrolled with a mean age of 33.8 ± 10.8 (16–66) years and a male/female ratio o... Endocrine journals http://www.medworm.com/rss/comments.php?id=5538456 Tue, 20 Dec 2011 16:46:56 +0100 5538456 http://www.medworm.com/index.php?rid=5525604&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F41h487702k66385p%2F In this study, we evaluated the relationship between this novel C5L2 SNP and development of type 2 diabetes mellitus (T2DM) in the Chinese Han population. A case–control study examining Chinese Han T2DM patients (n = 554) and healthy controls (n = 648) was performed to investigate the role of the 698C>T (P233L) C5L2 polymorphism. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to determine expression of this SNP. Heterozygote carriers of the 698CT C5L2 genotype were more frequent among T2DM patients (13.5%) than controls (3.2%; P < 0.001). The frequency of 698CT heterozygote carriers was significantly higher in women (12.8%) than in male subjects (5.7%, P < 0.001). The odds ratio (OR) of T... Endocrine journals http://www.medworm.com/rss/comments.php?id=5525604 Sat, 17 Dec 2011 16:43:31 +0100 5525604 http://www.medworm.com/index.php?rid=5525605&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl410w3468h4hx788%2F Abstract  To summarize promising areas of investigation in osteoporosis and to stimulate further research in this area, as discussed in a recent international conference. Over the recent years, there has been an improvement in the knowledge of molecular pathways involved in bone formation and resorption with the development of new drugs to treat osteoporosis. Intact parathyroid hormone, teriparatide, and anti-sclerostin monoclonal antibody are anabolic drugs, whereas denosumab and odanacatib are anti-resorptive drugs with more reversible effects as compared to bisphosphonates. Anabolic and anti-resorptive agents have different effects on bone, and research in this area includes the efficacy of combination and sequential therapies with them. New insights in the molecular pat... Endocrine journals http://www.medworm.com/rss/comments.php?id=5525605 Sat, 17 Dec 2011 06:45:13 +0100 5525605 http://www.medworm.com/index.php?rid=5515814&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0k3666719511656k%2F Abstract  The protective effects of TGF-β have been documented in various autoimmune diseases, mostly in organ-specific autoimmunity including type 1 diabetes mellitus (T1DM). However, TGF-β also plays a role as a pro-inflammatory mediator by induction of Th17 cytokine production. IL-23 also plays a key role in differentiation of Th17 cells, which are implicated in pathogenesis of autoimmune conditions including T1DM. The aim of this study was to investigate and compare the difference in the level of TGF-β1 and IL-23 gene expression in unstimulated peripheral blood mononuclear cells (PBMCs) of patients with different forms of diabetes compared with normal healthy controls subjects. Patients with T1DM were grouped as early-onset T1DM (N = 20) with age at diagnosi... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515814 Fri, 16 Dec 2011 17:28:51 +0100 5515814 http://www.medworm.com/index.php?rid=5515815&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F46621845u22v7ur7%2F Content Type Journal ArticleCategory Book ReviewPages 1-1DOI 10.1007/s12020-011-9546-2Authors Ezio Ghigo, Department of Medicine, University of Turin, Turin, Italy Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5515815 Thu, 15 Dec 2011 16:50:52 +0100 5515815 http://www.medworm.com/index.php?rid=5515816&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft74u45l2771104k7%2F Abstract  The aim of the study was to determine the association between birthweight, maternal medical history and acne, hirsutism, and menstrual disorder symptoms in Turkish adolescent population. Self-administered questionnaires were distributed to all volunteer female students at 15 secondary schools. The subjects’ body mass index, birthweight, age at menarche, pattern of menstrual cycle, and presence of acne or hirsutism problems were recorded. Maternal obstetric parameters, menstrual cycle, presence of acne or hirsutism at present and at adolescent period were also asked. The impact of birthweight and maternal history on acne, hirsutism, and menstrual disorder symptoms was evaluated. The results of the study showed that after exclusion of subjects born prematurely, to... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515816 Thu, 15 Dec 2011 16:50:51 +0100 5515816 http://www.medworm.com/index.php?rid=5515817&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh534372m2371v573%2F Abstract  Awareness of the need for prevention of glucocorticoid-induced fractures is growing, but glucocorticoid administration is often overlooked as the most common cause of nontraumatic osteonecrosis. Glucocorticoid-induced osteonecrosis develops in 9–40% of patients receiving long-term therapy although it may also occur with short-term exposure to high doses, after intra-articular injection, and without glucocorticoid-induced osteoporosis. The name, osteonecrosis, is misleading because the primary histopathological lesion is osteocyte apoptosis. Apoptotic osteocytes persist because they are anatomically unavailable for phagocytosis and, with glucocorticoid excess, decreased bone remodeling retards their replacement. Glucocorticoid-induced osteocyte apoptosis, a cumul... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515817 Thu, 15 Dec 2011 06:43:07 +0100 5515817 http://www.medworm.com/index.php?rid=5515818&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F671634142t327787%2F Abstract  Protein hormones from the anterior pituitary gland have well-established endocrine roles in their peripheral target glands. It is, however, now known that these proteins are also produced within many of their target tissues, in which they act as local autocrine or paracrine factors, with physiological and/or pathophysiological significance. This emerging concept is the focus of this brief review. Content Type Journal ArticleCategory ReviewPages 1-12DOI 10.1007/s12020-011-9557-zAuthors S. Harvey, Department of Physiology, University of Alberta, Edmonton, AB T6G 2H7, CanadaC. Arámburo, Departmento de Neurobiología Celular Y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional, Autónoma de Mexico, Querétaro, Qro 76230, MexicoE. J. S... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515818 Wed, 14 Dec 2011 16:40:42 +0100 5515818 http://www.medworm.com/index.php?rid=5515820&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl312430062310023%2F We report two adult male siblings of Jewish origin with late onset GS, who presented in their fifth decade of life with muscle weakness, hypokalemia, hypomagnesaemia, and metabolic alkalosis. Rapid clinical and biochemical improvement was achieved by replacement therapy with potassium and magnesium. Content Type Journal ArticleCategory Mini ReviewPages 1-5DOI 10.1007/s12020-011-9556-0Authors Farid Nakhoul, Nephrology & Hypertension Division, Faculty of Medicine, Baruch-Padeh Poryia Medical Center, Lower Galilee, IsraelNakhoul Nakhoul, Nephrology & Hypertension Division, Faculty of Medicine, Baruch-Padeh Poryia Medical Center, Lower Galilee, IsraelEvgenia Dorman, Laboratory of Molecular Medicine, Technion-Haifa, IsraelLiron Berger, Laboratory of Molecular Medicine, Technion-Haifa, ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515820 Wed, 14 Dec 2011 16:40:41 +0100 5515820 http://www.medworm.com/index.php?rid=5515819&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd144338v35171784%2F Abstract  The findings in hyperthyroid patients with Graves’ orbitopathy (GO) of antibodies against antigens shared between the thyroid and orbit, such as the TSH-receptor (TRAb) and a novel protein G2s (G2sAb), suggested a possible common therapeutic strategy. However, the gold therapeutic standard for hyperthyrodism in these patients remains still unsettled and is mainly based on personal experience. Studies on the effect of total thyroidectomy (TT) alone or followed by radioiodine ablation (RAI) of thyroid remnants showed often conflicting results. This longitudinal study was aimed at evaluating the influence of TT alone or followed by post-surgical RAI with respect to methimazole treatment on the activity and severity of GO in patients with hyperthyroidism and GO. Six... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515819 Wed, 14 Dec 2011 16:40:41 +0100 5515819 http://www.medworm.com/index.php?rid=5515822&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk1t5026855341504%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-011-9581-zAuthors Hutan Ashrafian, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM-Building, Praed Street, London, W2 1NY UK Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5515822 Wed, 14 Dec 2011 16:40:40 +0100 5515822 http://www.medworm.com/index.php?rid=5515821&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcml0v8n477444710%2F In this study, we investigate the mRNA expressions of Nav channel subtypes mediated differentially by the ERs in the DRGs of wild-type (WT) and estrogen receptor knockout (αERKO and βERKO) mice. By means of quantitative real-time PCR, we found that the expressions of Nav1.1, Nav1.7, Nav1.8, and Nav1.9 subtypes were elevated in αERKO and βERKO mice, whereas Nav1.6 mRNA decreased in αERKO, but not in βERKO mice. The mRNA expressions of Nav subtypes were increased in E2-treated WT ovariectomized animals. We also found that E2-regulation of Nav1.1 and Nav1.9 mRNA expressions is dependent on ERα, ERβ, and another ER, whereas E2-regulation of Nav1.8 appears to be in an ERβ-dependent manner. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s12020-011-9... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515821 Wed, 14 Dec 2011 16:40:40 +0100 5515821 http://www.medworm.com/index.php?rid=5515823&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F530407153u6n84n4%2F Abstract  Erythropoietin (Epo) is the principal regulator of erythropoiesis by inhibiting apoptosis and by stimulating the proliferation and differentiation of erythroid precursor cells. However, Epo also performs extra-erythropoietic actions of which the neuroprotective effects are among the most relevant. Apart from kidney and liver, Epo is also produced by the brain and the retina. In addition, Epo receptor (Epo-R) expression has also been found in the brain and in the retina, thus suggesting an autocrine/paracrine action which seems essential for the physiological homeostasis of both brain and retina. In this review, we will give an overview of the current concepts of the physiology of Epo and will focus on its role in the retina in both normal conditions and in the set... Endocrine journals http://www.medworm.com/rss/comments.php?id=5515823 Tue, 13 Dec 2011 17:06:27 +0100 5515823 http://www.medworm.com/index.php?rid=5487654&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft52286rg6293787x%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s12020-011-9571-1Authors Rajeshwary Ghosh, Sinha Institute of Medical Science and Technology, 288, Kendua, Main Road, Garia, Calcutta, 700 084 IndiaSoumendra K. Karmohapatra, Sinha Institute of Medical Science and Technology, 288, Kendua, Main Road, Garia, Calcutta, 700 084 IndiaGorachand Bhattacharya, Calcutta National Medical College and Hospital, Calcutta, 700014 IndiaA. Kumar Sinha, Sinha Institute of Medical Science and Technology, 288, Kendua, Main Road, Garia, Calcutta, 700 084 India Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5487654 Tue, 06 Dec 2011 19:09:43 +0100 5487654 http://www.medworm.com/index.php?rid=5487655&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7g8651t2g3311048%2F Abstract  The autonomic nerve fibres converge to the testis along two major pathways, the superior spermatic nerve (SSN) and the inferior spermatic nerve (ISN). The object of this work was to evaluate whether the addition of noradrenaline (NA) in the ganglionic compartment of two ex vivo systems: superior mesenteric ganglion (SMG)–SSN–testis, inferior mesenteric ganglion (IMG)–ISN–testis modulate androstenedione (A2), NA and nitrite release and to determine whether there are secretory differences between the right and the left testis. Each gonad with its respective ganglion was transferred into a cuvette with two compartments and incubated in a Dubnoff metabolic shaker. The testis incubation liquids were collected and analysed for NA by HPLC, A2 by RIA and nitrites b... Endocrine journals http://www.medworm.com/rss/comments.php?id=5487655 Tue, 06 Dec 2011 17:03:08 +0100 5487655 http://www.medworm.com/index.php?rid=5487656&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn584157428305p4t%2F Abstract  The cardinal features of Turner syndrome (TS) are short stature, congenital abnormalities, infertility due to gonadal dysgenesis, with sex hormone insufficiency ensuing from premature ovarian failure, which is involved in lack of proper development of secondary sex characteristics and the frequent osteoporosis seen in Turner syndrome. But sex hormone insufficiency is also involved in the increased cardiovascular risk, state of physical fitness, insulin resistance, body composition, and may play a role in the increased incidence of autoimmunity. Severe morbidity and mortality affects females with Turner syndrome. Recent research emphasizes the need for proper sex hormone replacement therapy (HRT) during the entire lifespan of females with TS and new hypotheses conc... Endocrine journals http://www.medworm.com/rss/comments.php?id=5487656 Tue, 06 Dec 2011 17:03:07 +0100 5487656 http://www.medworm.com/index.php?rid=5477103&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft304l364106472l0%2F Abstract  Vaspin (visceral adipose tissue-derived serpin; serpinA12) was originally identified as an adipokine, which is predominantly secreted from visceral adipose tissue in Otsuka Long-Evans Tokushima fatty (OLETF), an animal model of obesity and type 2 diabetes. Consistent with that higher vaspin serum concentrations and increased vaspin mRNA expression in human adipose tissue were found to be associated with obesity, insulin resistance, and type 2 diabetes in humans. However, the mechanisms how vaspin secretion may be linked to deterioration of glucose metabolism and insulin sensitivity are not entirely understood. Vaspin serum concentrations show a food intake-related diurnal variation. Vaspin is also expressed in the skin, hypothalamus, pancreatic islets, and stomach... Endocrine journals http://www.medworm.com/rss/comments.php?id=5477103 Fri, 02 Dec 2011 17:14:48 +0100 5477103 http://www.medworm.com/index.php?rid=5477104&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F33746r81532g261x%2F Abstract  HIV-infected patients on highly active antiretroviral therapy (HAART) have increased prevalence of a number of chronic metabolic disorders of multifactorial but unclear etiology. These include disorders of lipid metabolism with or without lipodystrophy, insulin resistance, and an increased prevalence of impaired glucose tolerance, diabetes mellitus, and cardiometabolic syndrome. While much attention has been focused on the lipid and cardiovascular disorders, few investigations have attempted to characterize the prevalence, incidence, etiology, mechanisms, and management of glycemic disorders in HIV patients. In this review, we have focused specifically on a comprehensive assessment of dysglycemia in the context of HIV infection and HAART. Content Type Journal ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5477104 Thu, 01 Dec 2011 19:20:48 +0100 5477104 http://www.medworm.com/index.php?rid=5469479&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl87210g1524m7516%2F Abstract  Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are relatively rare and heterogenous malignancies. Recent advances in histopathological classification according to the anatomical site of origin, proliferation rate, and extend of the disease have created a valid and powerful tool for the prognostic stratification of GEP-NETs. Chromogranin A is still the best available marker used for the biochemical confirmation of these tumors, but new more sensitive markers are urgently required. Although scintigraphy with 111In-octreotide has widely been applied for the localization and staging of GEP-NETs, newer imaging modalities based on the functional characteristics of these tumors are evolving aiming not only to facilitate the diagnosis but also prognosis and evalu... Endocrine journals http://www.medworm.com/rss/comments.php?id=5469479 Tue, 29 Nov 2011 22:21:57 +0100 5469479 http://www.medworm.com/index.php?rid=5469478&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv43895g77p156j57%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s12020-011-9567-xAuthors J. P. Brito, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USAE. Singh, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USAA. Basu, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5469478 Tue, 29 Nov 2011 22:21:57 +0100 5469478 http://www.medworm.com/index.php?rid=5458568&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg2n010836q0534j6%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-011-9566-yAuthors Maria Gueorguiev, Department of Endocrinology, St Bartholomew’s Hospital, London, EC1A 7BE UKAshley B. Grossman, Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, EC1M 6BQ UK Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5458568 Mon, 28 Nov 2011 16:51:31 +0100 5458568 http://www.medworm.com/index.php?rid=5441623&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5387k750wj84664%2F This study demonstrates that the level of lipids such as TG, HDL-C, HDL2, Apo AI, and Apo B, maybe regulated partly by genetic factors and their haplotype within the Apo11q gene cluster. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s12020-011-9526-6Authors Maryam S. Daneshpour, Obesity Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, P.O. Box 19195-4763, Tehran, I.R. IranBita Faam, Obesity Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, P.O. Box 19195-4763, Tehran, I.R. IranMohamad Ali Mansournia, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, I.R. IranMehdi Hedaya... Endocrine journals http://www.medworm.com/rss/comments.php?id=5441623 Mon, 21 Nov 2011 18:08:58 +0100 5441623 http://www.medworm.com/index.php?rid=5432241&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8t752413h1577504%2F This study investigated the effect of Mfn2 at an early stage of DN. Mfn2 was overexpressed by adenovirus-mediated gene transfer in streptozotocin-induced diabetic rats. Clinical parameters (proteinuria, albumin/creatinine ratio), pathological changes, ultra-microstructural changes in nephrons, expression of collagen IV and phosph-p38, ROS production, mitochondrial function, and apoptosis were evaluated and compared with diabetic rats expressing control levels of Mfn2. Endogenous Mfn2 expression decreased with time in DN. Compared to the blank transfection control group, overexpression of Mfn2 decreased kidney weight relative to body weight, reduced proteinuria and ACR, and improved pathological changes typical of the diabetic kidney, like enlargement of glomeruli, accumulation of EC... Endocrine journals http://www.medworm.com/rss/comments.php?id=5432241 Fri, 18 Nov 2011 06:58:56 +0100 5432241 http://www.medworm.com/index.php?rid=5432242&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp512110016g74511%2F Content Type Journal ArticleCategory Research LetterPages 1-4DOI 10.1007/s12020-011-9558-yAuthors Vito Guarnieri, Medical Genetics Unit, IRCCS “Casa Sollievo della Sofferenza” Hospital, Viale Padre Pio, 71013 San Giovanni Rotondo, FG, ItalyFilomena Baorda, Medical Genetics Unit, IRCCS “Casa Sollievo della Sofferenza” Hospital, Viale Padre Pio, 71013 San Giovanni Rotondo, FG, ItalyClaudia Battista, Endocrinology, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, FG, ItalyMichele Bisceglia, Pathology, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, FG, ItalyTeresa Balsamo, Laboratory of Oncology, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, FG, ItalyElisa Gruppioni, Oncologic Institute “F. Addarii... Endocrine journals http://www.medworm.com/rss/comments.php?id=5432242 Fri, 18 Nov 2011 06:58:55 +0100 5432242 http://www.medworm.com/index.php?rid=5409208&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr3813674766w716n%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-011-9564-0Authors Domenico Meringolo, Unità Operativa Semplice Dipartimentale di Endocrinologia, Ospedale di Bentivoglio, AUSL-BO, Bentivoglio, BolognaDavide Bianchi, Unità Operativa Semplice Dipartimentale di Endocrinologia, Ospedale di Bentivoglio, AUSL-BO, Bentivoglio, BolognaCarmelo Capula, Dipartimento di Medicina Sperimentale e Clinica, University of Catanzaro Magna Græcia, Viale Europa, Località Germaneto, 88100 Catanzaro, ItalyGiuseppe Costante, Dipartimento di Medicina Sperimentale e Clinica, University of Catanzaro Magna Græcia, Viale Europa, Località Germaneto, 88100 Catanzaro, Italy Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5409208 Mon, 14 Nov 2011 16:56:29 +0100 5409208 http://www.medworm.com/index.php?rid=5409209&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg071173443553l80%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-011-9561-3Authors Gülay Koçak, Department of Nephrology, Ankara Education and Research Hospital, Ankara, TurkeyErdem Koçak, Department of Gastroenterology, Ankara Education and Research Hospital, Keklikpınarı mahallesi, 240 sokak, Duru apartmanı, 8/6, Dikmen, Çankaya, Ankara, TurkeyAlper Azak, Department of Nephrology, Ankara Education and Research Hospital, Ankara, TurkeyHatice Ünverdi, Department of Pathology, School of Medicine, Ankara University, Ankara, Turkey Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5409209 Mon, 14 Nov 2011 16:56:28 +0100 5409209 http://www.medworm.com/index.php?rid=5409210&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp38750r201148048%2F Content Type Journal ArticleCategory Research LetterPages 1-3DOI 10.1007/s12020-011-9563-1Authors Michelle Y. Abshire, Center for Research in Reproduction and Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USASusan K. Blank, Center for Research in Reproduction and Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USASandhya Chhabra, Center for Research in Reproduction and Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USAChristopher R. McCartney, Center for Research in Reproduction and Division of Endocrinology, Department of Internal Medicine, University of ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5409210 Sat, 12 Nov 2011 16:54:44 +0100 5409210 http://www.medworm.com/index.php?rid=5409211&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm2820504236r4uj7%2F In conclusion GH treatment had beneficial effects on the abnormal body composition without serious adverse events making it a logic treatment option in adults with PWS. Content Type Journal ArticleCategory ReviewPages 1-9DOI 10.1007/s12020-011-9560-4Authors Rasmus Sode-Carlsen, Department of Paediatrics, Centre for Rare Diseases, Aarhus University Hospital Skejby, 8200 Aarhus N, DenmarkStense Farholt, Department of Paediatrics, Centre for Rare Diseases, Aarhus University Hospital Skejby, 8200 Aarhus N, DenmarkKai Fr. Rabben, Frambu, 1400 Siggerud, NorwayJens Bollerslev, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, NorwayThomas Schreiner, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, University of Oslo, Osl... Endocrine journals http://www.medworm.com/rss/comments.php?id=5409211 Fri, 11 Nov 2011 16:45:20 +0100 5409211 http://www.medworm.com/index.php?rid=5388184&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpw760707826118u5%2F The objective of this study was to test whether moderate food restriction affects serum leptin concentrations during the first half of pregnancy. We found that restriction to 50% of ad libitum consumption levels resulted in a significant decrease in serum leptin concentrations in both pregnant and non-pregnant female mice. There was no significant difference in serum leptin concentrations between non-pregnant females and at pregnancy day 11.5 when fed ad libitum. However, there was a difference in the source of leptin during pregnancy, with greater production in visceral fat in pregnant mice, and greater production in subcutaneous fat in non-pregnant mice. Leptin concentrations were dependent on time of day and time of sampling relative to feeding, particularly in restricted mice. T... Endocrine journals http://www.medworm.com/rss/comments.php?id=5388184 Mon, 31 Oct 2011 16:51:54 +0100 5388184 http://www.medworm.com/index.php?rid=5388183&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy01061kr1x17v64k%2F In this study, the gene expression of adrenomedullin (Adm) in the peripheral tissues which include lung, adrenal, kidney, and heart during development was investigated in the rat. The preproadrenomedullin (preproAdm) mRNA and mRNAs of its related receptor components, calcitonin receptor-like receptor (Crlr), and receptor activity-modifying proteins (Ramp1, 2 and 3) of the lung, adrenal, kidney, and heart were measured by real-time RT-PCR and the ADM peptide measured by radioimmunoassay in 1-, 7-, 21-day-old rats and the adult rats. From day 1 to 21, preproAdm mRNA levels increased with age in the lung, the kidney, and the heart but decreased with age in the adrenal. ADM levels, however, increased with age in the lung but decreased with age in the kidney, the adrenal, and the heart. The ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5388183 Mon, 31 Oct 2011 16:51:54 +0100 5388183 http://www.medworm.com/index.php?rid=5388182&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0p52318304705736%2F Abstract  Primary aldosteronism is now thought to be the commonest potentially curable and specifically treatable form of hypertension. The detection of primary aldosteronism is of utmost importance not only because it provides an opportunity for a targeted treatment, but also because it has been demonstrated that patients with primary aldosteronism are more prone to cardiovascular events and target organ damage than essential hypertensives. Normalization of blood pressure and hypokalemia should not be the only goal of treatment. Normalization of circulating aldosterone or mineralocorticoid blockade is necessary to prevent aldosterone-induced tissue damage that occurs independent of blood pressure. This review will focus on the current understanding and comprehensive manage... Endocrine journals http://www.medworm.com/rss/comments.php?id=5388182 Mon, 31 Oct 2011 16:51:54 +0100 5388182 http://www.medworm.com/index.php?rid=5388185&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5384412840522j0%2F This study will investigate whether serum chemerin levels are associated with coronary artery disease (CAD) independently of other cardiovascular risk factors. This study included a total of 430 subjects (239 with CAD and 191 with non-CAD) who underwent coronary angiography. Anthropometric measurements were performed and chemerin, glucose, lipid profiles, and other biochemical characteristics were measured. The severity of coronary atherosclerosis was estimated by the total number of diseased vessels and Gensini score. Serum chemerin levels were significantly higher in the CAD group than in the non-CAD group (P = 0.011). The odds ratios (95% CI) of CAD across increasing quartiles of serum chemerin were 1.04 (0.61–1.78), 1.08 (0.63–1.83), and 1.87 (1.07–3.24), (P ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5388185 Mon, 31 Oct 2011 16:51:52 +0100 5388185 http://www.medworm.com/index.php?rid=5388186&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F25j4076535r64271%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12020-011-9549-zAuthors Masanori Yoshida, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounenn-cho, Nakagawa-ku, Nagoya, 454-8502 JapanHiroshi Umeda, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounenn-cho, Nakagawa-ku, Nagoya, 454-8502 JapanShintaro Iwama, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounenn-cho, Nakagawa-ku, Nagoya, 454-8502 JapanSeiko Nakayama, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounenn-cho, Nakagawa-ku, Nagoya, 454-8502 JapanMisaki Miyata, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounenn-cho, Nakagawa-ku, Nagoya, 454-8502 Jap... Endocrine journals http://www.medworm.com/rss/comments.php?id=5388186 Sun, 30 Oct 2011 05:37:37 +0100 5388186 http://www.medworm.com/index.php?rid=5361536&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F14gg422232172617%2F Abstract  The aim of this study was to measure the serum AMH (anti-Mullerian hormone) concentrations in a group of boys with or without cryptorchidism, evaluation of karyotypes, testicular position, morphology, and major length of the undescended testes. Fifty boys who were 1–4 years old (median = 2.4 years) with unilateral cryptorchidism were evaluated. All of them underwent orchidopexy in 2010. Prior to the procedure, all of the subjects had undergone karyotyping to exclude chromosomal abnormalities. Fifty healthy boys within the same age range (median = 2.1 years) admitted for planned inguinal hernia repair in 2010, served as controls. Blood samples were collected, while obtaining blood for standard laboratory tests routinely performed... Endocrine journals http://www.medworm.com/rss/comments.php?id=5361536 Sat, 29 Oct 2011 05:47:57 +0100 5361536 http://www.medworm.com/index.php?rid=5361538&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F155h012x011gl2t8%2F Abstract  Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-secreting tumors which arise from the adrenal glands or sympathetic neuronal tissue. Malignant transformation of these tumors occurs in a significant proportion and may therefore lower overall survival rates. In patients with PPGLs it is impossible to identify malignant disease without the presence of metastatic disease, something which can occur as long as 20 years after initial surgery. Early identification of malignant disease would necessitate a more aggressive treatment approach, something which may result in better disease outcome. We have therefore reviewed possible predictors of malignancy and current developments in order to help clinicians to swiftly assess malignant potential in patient... Endocrine journals http://www.medworm.com/rss/comments.php?id=5361538 Fri, 28 Oct 2011 16:57:36 +0100 5361538 http://www.medworm.com/index.php?rid=5361537&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F93vg6541u001194u%2F Abstract  In recent years, there has been growing interest in the potential use of combination therapy in the management of osteoporosis in postmenopausal women. Possible regimens include sequential or combined use of anti-resorptive drugs or combinations of anabolic and anti-resorptive agents, given concurrently or in sequence. Combined therapy with anti-resorptive drugs usually produces greater increases in bone mineral density (BMD) than monotherapy but there is no evidence that this results in greater anti-fracture efficacy. The use of bisphosphonates before strontium ranelate or PTH peptides blunts the BMD response. Combined PTH and anti-resorptive therapy results in more rapid gains in spine BMD and a greater increase in hip BMD than PTH monotherapy in the first year ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5361537 Fri, 28 Oct 2011 16:57:36 +0100 5361537 http://www.medworm.com/index.php?rid=5315200&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff027r32q631wn4k8%2F Abstract  The brain is a target for organizational and activational effects of oestrogens synthesized de novo or transported from the peripheral organs. A neuroprotective role of oestrogens has been documented in a variety of vertebrates. In the present study in the catfish Heteropneustes fossilis, we have demonstrated that estradiol-17β (E2), the major circulating oestrogen at low dosages (0.05 and 0.1 μg/g body weight of fish for 3 days) stimulated hypothalamic tyrosine hydroxylase (TH) activity, and countered the negative effects of ovariectomy (3-week) or α-methylparatyrosine (α-MPT: 250 μg/g body weight, a competitive inhibitor of TH). In contrast, high dosages of E2 (1 and 2 μg/g body weight of fish for 3 days) were inhibitory and further ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5315200 Wed, 12 Oct 2011 16:33:58 +0100 5315200 http://www.medworm.com/index.php?rid=5315202&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F80m3np804484162q%2F Abstract  Neuropathy and peripheral artery disease represent the main pathophysiological conditions underlying diabetic foot. Several studies showed that Lipoprotein(a)—Lp(a)—and homocysteine (Hcy) can be associated with diabetic complications, but their relationship with diabetic foot is unclear. Aim of this study was to investigate whether Lp(a) and Hcy were associated with diabetic foot ulcerations, classified according to the presence of peripheral artery disease (PAD) or neuropathy. From among consecutive type 2 diabetic attending at the Diabetic Foot Clinic 27 subjects with vascular diabetic foot (VDF), 43 with neuropathic diabetic foot (NDF) and 52 controls without foot ulceration, neuropathy, and PAD were enrolled. Both Lp(a) (26.1 ± 22.7 vs. 14.9&nbsp... Endocrine journals http://www.medworm.com/rss/comments.php?id=5315202 Tue, 11 Oct 2011 05:48:08 +0100 5315202 http://www.medworm.com/index.php?rid=5315201&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9493532381330322%2F This study was performed to ascertain whether a relationship exists between thyroid function and blood pressure in school-aged Chinese subjects without overt thyroid disease. A cross-sectional survey of 880 subjects (541 females and 339 males) aged 7–18 years in Bengbu, Anhui province was conducted. The investigation, which was based on a stratified random cluster sampling method, included a questionnaire and measurements of blood pressure, height, and body weight. Fasting blood samples were taken for measurements of thyroid-stimulating hormone (TSH), free 3,5,3′-triiodothyronine (FT3) and free thyroxine (FT4). Serum TSH and FT3 were positively correlated with systolic and diastolic blood pressure Z scores (SBP-Z and DBP-Z) even after adjusting for body mass index (BMI) (P&nbs... Endocrine journals http://www.medworm.com/rss/comments.php?id=5315201 Tue, 11 Oct 2011 05:48:08 +0100 5315201 http://www.medworm.com/index.php?rid=5315203&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff7p02556282626x3%2F Abstract  Hypothalamic–pituitary–adrenal (HPA) axis control may be impaired in type 2 diabetes (T2DM). Glucocorticoids increase consumption of low quality foods high in calories, sugar, and fat. We explored the relationship between cortisol levels, poor blood glucose control, and food quality choice in T2DM. Twenty-seven healthy controls were age-, gender- and education-matched to 27 T2DM participants. Standard clinical blood tests and cortisol values were measured from fasting blood samples. Participants recorded all consumed food and drink items in a consecutive 3-day food diary. Diaries were analyzed for “high quality” and “low quality” foods using a standardized method with high reliability (0.97 and 0.86, respectively). Controlling for education, body mass ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5315203 Sun, 09 Oct 2011 05:36:38 +0100 5315203 http://www.medworm.com/index.php?rid=5315204&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw6l0h43504mp55v5%2F In conclusion, the findings of this study indicate that the intense resistance exercise can lead to changes in blood concentrations of IGF-1 system components which are observable in blood circulation over time and the amounts of changes depend on subjects’ fitness levels and exercise variables. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s12020-011-9537-3Authors Shirin Hasani-Ranjbar, Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences, 5th Floor, Shariati Hospital, North Kargar Ave., 14114 Tehran, IranEhsan Soleymani Far, Physical Education & Sport Sciences, Tarbiat Moallem University, Tehran, IranRamin Heshmat, Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences, 5th Floor, Shariat... Endocrine journals http://www.medworm.com/rss/comments.php?id=5315204 Sat, 08 Oct 2011 15:44:20 +0100 5315204 http://www.medworm.com/index.php?rid=5297476&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5rlu3v5143q10310%2F Abstract  The optimal treatment strategy in a goiter patient depends—among other factors—on goiter size, the degree of cosmetic or compressive symptoms, the age of the patient, the impact on the upper airways, the wish to maintain normal thyroid function, the ability of the thyroid gland to take up 131I, and the possibility of thyroid malignancy. When treatment is warranted in a patient with benign goiter, the choice usually stands between surgery and 131I-therapy. Focal destructive treatment, by ethanol sclerotherapy or interstitial laser photocoagulation, may be considered in patients with a solitary benign nodule. If thyroid hyperfunction due to nodular autonomy is the dominant problem, life-long anti-thyroid drug treatment may be relevant in elderly individuals. With... Endocrine journals http://www.medworm.com/rss/comments.php?id=5297476 Wed, 05 Oct 2011 05:50:25 +0100 5297476 http://www.medworm.com/index.php?rid=5286313&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh201124214511r11%2F Abstract  In vitro and animals models have shown follicle-stimulating hormone (FSH) effects on osteoclastic function, and FSH levels seem to influence bone loss independently of estrogen concentrations in humans. Our aim was to evaluate the role of serum FSH measurement in the assessment of bone resorption in postmenopausal women. We conducted a cross-sectional study including 92 postmenopausal healthy women aged 56.2 (3.6) and 7.2 (4) years since menopause. Serum FSH, luteinizing hormone (LH), estradiol (E2) and bone turnover markers as osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured. We analyzed the relationship between serum levels of gonadotropins, E2, and bone turnover markers. Serum levels of OC and CTX were positively related to FSH... Endocrine journals http://www.medworm.com/rss/comments.php?id=5286313 Sat, 01 Oct 2011 05:48:56 +0100 5286313 http://www.medworm.com/index.php?rid=5286312&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F23m477t0634q326x%2F Abstract  The prevalence of obesity in children has increased in developed countries in the last decades. It is associated with alterations in glucose metabolism that may be present in childhood. To assess the frequency of glucose metabolism alterations and insulin resistance and their possible determinants in a sample of obese children from Valladolid (Spain), we retrospectively studied 100 obese children and adolescents (11.59 ± 2.73 years). Anthropometric measures, biochemical parameters, and oral glucose tolerance test (OGTT) were performed. Insulin resistance was evaluated with fasting insulin, HOMA index, and insulin values in OGTT. Impaired glucose tolerance was found in 15% of the sample, and was the most frequent of glucose metabolism alterations. I... Endocrine journals http://www.medworm.com/rss/comments.php?id=5286312 Sat, 01 Oct 2011 05:48:56 +0100 5286312 http://www.medworm.com/index.php?rid=5286314&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1845712719752512%2F In this study, we aimed to compare macroprolactinemic patients (group I) with the true hyperprolactinemic patients (group II) for the presence of pituitary adenoma. We investigated 161 patients with hyperprolactinemia, whose magnetic resonance imaging records of the pituitary were taken. All patients were questioned for irregular menses, infertility and examined for galactorrhea. Patients were screened for macroprolactinemia by polyethylene glycol precipitation, and a recovery of ≤40% and normal monomeric PRL level was taken as an indication of significant macroprolactinemia. Of 161 patients with hyperprolactinemia, 60 (37.26%) had macroprolactinemia. PRL levels of group II were lower than those of group I (P = 0.011), although monomeric PRL levels of group II were higher... Endocrine journals http://www.medworm.com/rss/comments.php?id=5286314 Fri, 30 Sep 2011 06:23:32 +0100 5286314 http://www.medworm.com/index.php?rid=5286315&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft6371jx36w632653%2F Abstract  Thyroid hormone secretion suppresses the expression of thyroid stimulating hormone (TSH), both of which are strictly controlled by a negative feedback loop between the hypothalamus-pituitary and thyroid. Pituitary resistance to thyroid hormone (PRTH) is defined as resistance to the action of thyroid hormone that is more severe in the pituitary than at the peripheral tissue level. Although the molecular basis of PRTH is not well understood, the clinical issue mainly involves imbalance between the hypothalamus-pituitary and peripheral thyroid hormone responsivity, which may induce peripheral thyrotoxic phenomena. Here, we review the pathogenesis and molecular aspects of PRTH, present a single case with inappropriate TSH secretion suffering from thyrotoxicosis treate... Endocrine journals http://www.medworm.com/rss/comments.php?id=5286315 Thu, 29 Sep 2011 06:07:24 +0100 5286315 http://www.medworm.com/index.php?rid=5261455&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqr6370r836106426%2F Abstract  Both fasting and postprandial hypertriglyceridemia have been identified as risk markers for cardiovascular disease. High-sensitivity C-reactive protein (hs-CRP), known to independently predict future cardiovascular disease, has also been reported to be a direct participant in the progression of atherosclerosis. We evaluated whether or not fasting and/or postprandial hypertriglyceridemia influence hs-CRP of men with normal glucose tolerance. According to the triglyceride (TG) level, measured before and 1 and 2 h after a meal tolerance test, subjects were classified into a normotriglyceridemic (NTG) group (n = 86), a postprandial hypertriglyceridemia (PHTG) group (n = 50), or a fasting hypertriglyceridemia (FHTG) group (n = 53). Hs-C... Endocrine journals http://www.medworm.com/rss/comments.php?id=5261455 Sat, 24 Sep 2011 05:43:24 +0100 5261455 http://www.medworm.com/index.php?rid=5261454&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq753043213351237%2F Abstract  Globular adiponectin (gAd) has anti-atherogenic effects on the vascular wall. Intermittent hyperglycemia induces endothelial cells (ECs) injury but the physiological factors that may protect against ECs damage are largely unknown. In the present study, we investigated the effect of gAd on ECs dysfunction induced by intermittent high glucose. The gAd significantly attenuated intermittent high glucose-induced apoptosis and oxidative stress in human umbilical vein endothelial cells. This was achieved by decreasing caspase-3 and 3-nitrotyrosine protein expression, increasing nitric oxide (NO) secretion and phosphorylation of Akt, AMPK, and endothelial nitric oxide synthase protein expression. Pretreatment with a phosphatidylinositol 3’ kinase (PI3K) inhibitor, LY294... Endocrine journals http://www.medworm.com/rss/comments.php?id=5261454 Sat, 24 Sep 2011 05:43:24 +0100 5261454 http://www.medworm.com/index.php?rid=5238594&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj557170q372173t5%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s12020-011-9533-7Authors Ana Chiesa, División Endocrinología, Hospital de Niños ‘‘Ricardo, Gutiérrez’’, Centro de Investigaciones Endocrinológicas, CEDIE-CONICET, Gallo 1330, 1425 Buenos Aires, ArgentinaMaria Cecilia Olcese, Laboratorio de Biología Molecular, Cátedra de Genética y Biología Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, ArgentinaPatricia Papendieck, División Endocrinología, Hospital de Niños ‘‘Ricardo, Gutiérrez’’, Centro de Investigaciones Endocrinológicas, CEDIE-CONICET, Gallo 1330, 1425 Buenos Aires, ArgentinaAlicia Martinez, División Endocrinología, Hospital de Niños ‘‘Ricardo, Gutiérrez’’, Centro de Investigacion... Endocrine journals http://www.medworm.com/rss/comments.php?id=5238594 Sat, 17 Sep 2011 17:07:17 +0100 5238594 http://www.medworm.com/index.php?rid=5226862&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1l253u24m2lr6r6%2F Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s12020-011-9534-6Authors Paul Valensi, Department of Endocrinology-Diabetology-Nutrition AP-HP, Jean Verdier Hospital, Paris-Nord University, CRNH-IdF, Bondy, France Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=5226862 Fri, 16 Sep 2011 16:51:34 +0100 5226862 http://www.medworm.com/index.php?rid=5209648&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff581583588h65341%2F Abstract  Galanin is a neuropeptide widely distributed in the central and peripheral nervous systems. Although its role in non-neural cells is poorly understood, it is known that during inflammation, the dermis layer of the skin produces and releases galanin. The aim of this report is to study the expression of galanin in granulation tissue. After inducing inflammation by cotton thread implantation, galanin-like immunoreactivity (galanin-LI) in plasma reached a maximum on the third day. Galanin-LI was observed in fibroblast-like cells occurring close to collagen fibers in developing granulation tissue. Furthermore, galanin receptor subtypes 1 and 2 (GALR1 and GALR2)-expressing cells were observed around microvessels and were found to produce desmin. Galanin was injected alo... Endocrine journals http://www.medworm.com/rss/comments.php?id=5209648 Mon, 05 Sep 2011 16:13:47 +0100 5209648 http://www.medworm.com/index.php?rid=5209647&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp23g5k1155p062k8%2F Abstract  Non-alcoholic fatty liver disease (NAFLD) is usually a silent disease that occurs in a very high proportion of people with features of the metabolic syndrome, including overweight, insulin resistance and type 2 diabetes. Because obesity and type 2 diabetes are now extremely common in Westernised societies, it is likely that the prevalence of NAFLD increases markedly in the future. Although previously it was thought that NAFLD was harmless, it is now recognised that NAFLD can be a progressive liver condition that increases risk of cirrhosis, end-stage liver disease and hepatocellular carcinoma. Additionally, liver fat accumulation causes insulin resistance and increases risk of type 2 diabetes. Increasing evidence now shows NAFLD is a risk factor for cardiovascular... Endocrine journals http://www.medworm.com/rss/comments.php?id=5209647 Mon, 05 Sep 2011 16:13:47 +0100 5209647 http://www.medworm.com/index.php?rid=5184673&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F01614w22478h5l32%2F Abstract  The TALLYHO/JngJ (TH) mouse is a novel polygenic model of type 2 diabetes and exhibits obesity, hyperglycemia (males), hyperinsulinemia, hyperlipidemia, and enlarged pancreatic islets. Since the kidney is damaged by hyperglycemia in other animal models, the present study aimed to determine the kidney phenotype of TH mice using immunoblot and histological analyses of the kidneys of 6-week-old (prediabetic) and 16-week-old TH mice. Interestingly, even 6-week-old male TH mice showed significant increases in kidney weight, compared to C57BL/B6 (B6) mice. Cuboidal parietal epithelium was observed in the Bowman’s capsule in male TH mice at the prediabetic age. Water accumulated inside the kidneys of male TH mice in an age-dependent manner, but not in B6 mice. Since Sw... Endocrine journals http://www.medworm.com/rss/comments.php?id=5184673 Tue, 30 Aug 2011 15:57:19 +0100 5184673 http://www.medworm.com/index.php?rid=5184674&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnk74v80858747667%2F In this study, 17βHSD2 expression level and enzymatic activity, and estrogen receptor α and β expression levels, were measured in endothelial cell cultures from umbilical arteries (HUAEC) and vein (HUVEC) using real-time quantitative PCR, western blot, and radiolabeled steroids. 17βHSD2-specific activities were also measured in proximal and distal segments of freshly isolated umbilical cord arteries and vein. 17βHSD2 mRNA level and activity were higher in HUAEC than in HUVEC. Activity was higher in umbilical arteries than in the umbilical vein. In arteries, enzymatic activity was higher near the placenta, suggesting a gradient of expression. No difference was found in ERα expression, whereas ERβ was expressed at a higher level in HUAEC than in HUVEC. Expression profiles of est... Endocrine journals http://www.medworm.com/rss/comments.php?id=5184674 Mon, 29 Aug 2011 15:58:50 +0100 5184674 http://www.medworm.com/index.php?rid=5176087&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9007402714878h38%2F In this report, using whole cell patch-clamp recordings, we assessed the acute action of ghrelin on voltage-activated Ca2+ currents in GH3 rat somatotrope cell line. Ca2+ currents were divided into three types (T, N, and L) through two different holding potentials (−80 and −40 mV) and specific L-type channel blocker (nifedipine, NFD). We demonstrated that ghrelin significantly and reversibly decreases all three types of Ca2+ currents in GH3 cells through GHS receptors on the cell membrane and down-stream signaling systems. With different signal pathway inhibitors, we observed that ghrelin-induced reduction in voltage-gated Ca2+ currents in GH3 cells was mediated by a protein kinase G-dependent pathways. As ghrelin also stimulates Ca2+ release and prolongs the membrane depolari... Endocrine journals http://www.medworm.com/rss/comments.php?id=5176087 Sat, 27 Aug 2011 05:55:44 +0100 5176087 http://www.medworm.com/index.php?rid=5170759&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1mh5g811416g257%2F Abstract  Parathyroid hormone (PTH) plays a critical role in calcium and phosphorus metabolism. Interestingly, in two forms of hyperparathyroidism (excessive amount of PTH in the serum), the metabolic disturbances in patients with chronic kidney disease (CKD) significantly differ from those with primary hyperparathyroidism (PHP). Since an intuitive understanding of these PTH-linked regulatory mechanisms are hardly possible, we developed a mathematical model using clinical data (1586 CKD and 40 PHP patients). The model was composed of a set of ordinary differential equations, in which the regulatory mechanism of PTH together with other key factors such as 1,25-Dihydroxyvitamin D (1,25(OH)2D) and calcium was described in the tissues including bone, the kidney, the serum, and t... Endocrine journals http://www.medworm.com/rss/comments.php?id=5170759 Fri, 26 Aug 2011 16:16:36 +0100 5170759 http://www.medworm.com/index.php?rid=5170760&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flr5743t626075822%2F Abstract  The process of homo- and/or heterodimerization of G-protein coupled receptors (GPCRs) and receptor tyrosine kinase (RTK) families are crucial for implicating the fundamental properties of receptor proteins including receptor expression, trafficking, and desensitization as well as signal transduction. The members of GPCR and RTK family constitute largest cell surface receptor proteins and regulate physiological functions of cells in response to external and internal stimuli. Notably, GPCRs and RTKs play major role in regulation of several key cellular functions which are associated with several pathological conditions including cancer biology, neurodegenerative and cardiovascular diseases. The focus of this review is to highlight the recent findings on the possible... Endocrine journals http://www.medworm.com/rss/comments.php?id=5170760 Fri, 26 Aug 2011 05:48:59 +0100 5170760 http://www.medworm.com/index.php?rid=5170761&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk56l477494r35107%2F Abstract  Approximately two-thirds of neuroendocrine tumours (NET) occur in the gastrointestinal tract and over 60% present with metastases. With greater insight into molecular pathways involved in tumour progression, opportunities are presented for the use of targeted therapies in NET. Although a wide array of targeted agents has been investigated, only a handful has emerged as forerunners from recent clinical trials. This literature review focuses on the use of anti-angiogenic monoclonal antibody bevacizumab, as well as small molecule inhibitors sunitinib and everolimus. Content Type Journal ArticleCategory Mini ReviewPages 1-6DOI 10.1007/s12020-011-9513-yAuthors Kein-Leong Yim, Gastrointestinal Cancer and Lymphoma Research Unit, The Royal Marsden NHS Foundation Trus... Endocrine journals http://www.medworm.com/rss/comments.php?id=5170761 Fri, 26 Aug 2011 05:48:57 +0100 5170761 http://www.medworm.com/index.php?rid=5170762&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy012508r501t24l8%2F Abstract  Resistance to thyroid hormone (RTH) is characterized by elevated levels of thyroid hormones, normal or slightly increased TSH levels respondent to TRH, resistance to thyroid hormone administration, and variable clinical expression. To describe the diverse clinical and biochemical findings of six children from five unrelated families with molecular diagnosis of RTH (0.5–12.7 years) and their follow-up (3–20 years). All RTH patients and 4 affected parents’ harbored mutations in exons 9 or 10 of the thyroid receptor β gene: p.M313T (de novo), pN331D, p.L341P, p.L346F, and p.P453L. At consultation 5/6 had goiter, 4/6 tachycardia, and 3/5 learning disabilities. Median hormone levels were: T4 257.4 nmol/l (NR: 77.2–180.2); FreeT4 39.9 pmol/(N... Endocrine journals http://www.medworm.com/rss/comments.php?id=5170762 Thu, 25 Aug 2011 15:52:50 +0100 5170762 http://www.medworm.com/index.php?rid=5162820&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxuq6j01v6u027x3k%2F This study was to investigate whether the common polymorphisms of CD40 and CTLA4 genes confer susceptibility to AITD in the Chinese population. A set of unrelated subjects including 303 GD patients, 208 HT patients, and 215 matched healthy controls were recruited. SNPs were genotyped by the method of PCR-RFLP. (1) As for CD40 C/T-1 SNP, only a significant difference was found in allele frequencies between GD and control groups (P = 0.033). (2) On the part of CTLA-4 A/G49 SNP, significant differences were found in genotype and allele frequencies between GD and control groups (P = 7.0 × 10−5 and P = 0.002, respectively), and similar results were found between HT and control groups (P = 0.015 and P = 0.003, respectively). (3) Th... Endocrine journals http://www.medworm.com/rss/comments.php?id=5162820 Wed, 24 Aug 2011 16:06:05 +0100 5162820 http://www.medworm.com/index.php?rid=5162822&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk7727p8427828211%2F We report a 22-year-old female initially diagnosed at age 12 with familial hypopituitarism due to PROP1 mutation, who presented with coma and respiratory arrest (acute hyponatremia). She was urgently treated in Intensive Care Unit of Emergency Center with hypertonic saline and stress doses of hydrocortisone, which resulted in the fast increase of plasma osmolality resulting in the osmotic demyelination syndrome. Simultaneously and incidentally on computed tomography scan a large sellar and suprasellar mass were reported as possible Rathke’s cleft cyst or craniopharyngioma. Once the patient was stable, ACTH deficiency was documented. She remained replaced with hydrocortisone and subsequently underwent transphenoidal surgery. The removed sellar content revealed no pituitary adenoma ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5162822 Wed, 24 Aug 2011 07:19:34 +0100 5162822 http://www.medworm.com/index.php?rid=5162821&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4513465526431468%2F Content Type Journal ArticleCategory Research LetterPages 1-3DOI 10.1007/s12020-011-9525-7Authors D. Russo, Department of Pharmacobiological Sciences, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, ItalyG. Costante, Department of Clinical and Experimental Medicine, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, ItalyR. Bruno, Hospital of Tinchi-Pisticci, 75100 Matera, ItalyM. Sponziello, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, 00161 Rome, ItalyG. Tamburrano, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, 00161 Rome, ItalyM. Dima, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, 00161 Rome, ItalyR. Sacco, Department of ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5162821 Wed, 24 Aug 2011 07:19:34 +0100 5162821 http://www.medworm.com/index.php?rid=5162823&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy05g44w34vgv4247%2F This study first shows that ED can improve the effectiveness in discriminating diabetic men to screen for asymptomatic CAD, when it is added to the list of RFs of the current screening guidelines. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s12020-011-9523-9Authors Carmine Gazzaruso, Internal Medicine, Diabetes, Endocrine-Metabolic Diseases and Cardiovascular Prevention Unit and the Centre for Applied Clinical Research (Ce.R.C.A.), Clinical Institute “Beato Matteo”, Corso Pavia 84, Vigevano, 27029 Pavia, ItalyAdriana Coppola, Internal Medicine, Diabetes, Endocrine-Metabolic Diseases and Cardiovascular Prevention Unit and the Centre for Applied Clinical Research (Ce.R.C.A.), Clinical Institute “Beato Matteo”, Corso Pavia 84, Vigevano, 27029 Pav... Endocrine journals http://www.medworm.com/rss/comments.php?id=5162823 Tue, 23 Aug 2011 05:57:29 +0100 5162823 http://www.medworm.com/index.php?rid=5162824&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl9r2427361rk75g5%2F Abstract  Results from investigations of human genomics which utilize intact tissue biopsy specimens maybe compromised due to a host of uncontrolled variables including cellular heterogeneity of a sample collected under diverse conditions, then processed and stored using different protocols. To determine the cellular origin and assess relationships of mRNA expression of two genes reported to be co-expressed in human breast carcinoma (estrogen receptor-α, ESR1 and X-box binding protein 1, XBP1), gene expression analyses were performed with intact tissue sections and compared with those of laser capture microdissection (LCM)-procured carcinoma and stromal cells from serial sections of the same tissue. Frozen sections of human breast carcinomas were first evaluated for struct... Endocrine journals http://www.medworm.com/rss/comments.php?id=5162824 Sun, 21 Aug 2011 05:37:00 +0100 5162824 http://www.medworm.com/index.php?rid=5162825&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmxh021070268w336%2F Abstract  Roux-en-Y gastric bypass surgery (GBP) results in 30–40% sustained weight loss and improved type 2 diabetes in up to 80% of patients. The relative contribution of the gut neuroendocrine changes after GBP versus the weight loss has not been fully elucidated. There are clear differences between weight loss by GBP and by dietary intervention or gastric banding. One of them is the enhanced post-prandial release of incretin hormones and the recovery of the incretin effect on insulin secretion after GBP, not seen after diet-induced weight loss. The favorable changes in incretin hormones after GBP result in recovery of the early phase insulin secretion and lower post-prandial glucose levels during oral glucose administration. The enhanced incretin response may be relat... Endocrine journals http://www.medworm.com/rss/comments.php?id=5162825 Fri, 19 Aug 2011 06:40:02 +0100 5162825 http://www.medworm.com/index.php?rid=5132656&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm60390277l03u510%2F Abstract  Type 2 diabetes mellitus (T2DM) is a major health priority globally, having achieved pandemic status in the twenty-first century. Several gastrointestinal procedures that were primarily designed to treat morbid obesity result in dramatic remission of diabetes. Studies in experimental rodent models and humans have shown that the glycemic benefits of surgery are at least in part weight-independent and extend to non-morbidly obese subjects with T2DM. Bariatric procedures differ in their ability to ameliorate type 2 diabetes, with intestinal bypass procedures being more effective than purely restrictive procedures. Several studies have demonstrated that the benefits of bariatric surgery extend beyond amelioration of hyperglycemia and include improvement in other cardio... Endocrine journals http://www.medworm.com/rss/comments.php?id=5132656 Sat, 13 Aug 2011 06:12:56 +0100 5132656 http://www.medworm.com/index.php?rid=5132657&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr55252n043144034%2F Abstract  Hearing loss has commonly been reported in association with thyroid disorders and during treatment with propylthiouracil. The relationship between hyperthyroidism and the auditory system has not been previously investigated. The aim of this cross-sectional, case–control study was to investigate hearing loss in patients with Graves’ disease (GD). The study population consisted of patients with newly diagnosed GD and healthy controls. Pure tone audiometry at frequencies of 250, 500, 1000, 2000, 4000 and 8000 Hz, along with immittance measures including tympanometry and acoustic reflex tests, were performed in all participants. Twenty-two GD patients and 22 healthy controls consented to inclusion in the study. The differences between groups with regards to a... Endocrine journals http://www.medworm.com/rss/comments.php?id=5132657 Thu, 11 Aug 2011 06:56:04 +0100 5132657 http://www.medworm.com/index.php?rid=5110275&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61q56164043876u3%2F Abstract  N-terminal propeptide of type I procollagen (PINP) is a marker of newly formed type I collagen. However, its role in hypophosphatemic rickets/osteomalacia has not yet been established. Metabolic bone markers were examined in patients with oncogenic osteomalacia (OOM) and X-linked hypophosphatemic rickets (XLH), and in healthy controls. OOM and XLH patients were found to have hypophosphatemia secondary to elevated levels of serum fibroblast growth factor 23 (FGF-23). OOM patients had reduced levels of 1,25-dihydroxy vitamin D (1,25D) compared with XLH patients and healthy controls, despite attenuation of the reduction in these levels in the XLH patients secondary to active vitamin D supplementation. In contrast to patients with XLH, OOM patients showed a significant... Endocrine journals http://www.medworm.com/rss/comments.php?id=5110275 Sat, 06 Aug 2011 05:53:43 +0100 5110275 http://www.medworm.com/index.php?rid=5080505&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F006m107087301838%2F The objective of this study was to determine whether elevated ALT and NAFLD were useful for early and definitive determination of IR and to compare their coexistence with conventional risk factors in young Han males. Anthropometric and metabolic measurements were assessed in 216 young Han males (19.3 ± 0.8 years). NAFLD was diagnosed using ultrasonography, and the homeostasis model assessment of insulin resistance (HOMA-IR) served as an index of IR. Subjects in the fourth HOMA-IR quartile had a significantly higher frequency of abdominal obesity, elevated blood pressure and ALT, and NAFLD compared to subjects in quartiles 1–3 (P < 0.05). Using multivariate logistic regression analysis, risk of IR increased by 2.33-fold (95% CI: 1.00–5.42, P = ... Endocrine journals http://www.medworm.com/rss/comments.php?id=5080505 Wed, 27 Jul 2011 18:47:22 +0100 5080505 http://www.medworm.com/index.php?rid=5080507&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb7215v3162114323%2F Abstract  Recent publications suggest the utility of temozolomide (TMZ) in the management of aggressive pituitary adenomas and carcinomas, resistant to conventional treatments. The response to TMZ is inversely correlated with tumoral expression of O-6 methylguanine DNA methyl transferase (MGMT). Therefore, we aimed to assess MGMT immunoexpression in pure GH-secreting pituitary adenomas, in an effort to predict the likelihood of response to TMZ, and to correlate MGMT immunoexpression with Ki-67 LI and cytokeratin (CK) distribution pattern. Our material consisted of 36 GH-secreting pituitary adenomas (21 female,15 male, mean age 42.5 ± 10.5), operated at our center between 2003 and 2010. Immunostaining for MGMT, Ki-67, and CK was performed using avidin–biotin-pero... Endocrine journals http://www.medworm.com/rss/comments.php?id=5080507 Wed, 27 Jul 2011 05:49:16 +0100 5080507 http://www.medworm.com/index.php?rid=5080506&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc5477407487h2035%2F Abstract  To report 12 cases of pregnancy-associated fulminant type 1 diabetes mellitus (PF) found in China from 2003 to 2010. The clinical and biochemical characteristics of these cases with PF were compared with a group of cases of child-bearing age with fulminant type 1 diabetes that was not associated with pregnancy (NPF). The clinical and biochemical characteristics of 12 PF cases were analyzed retrospectively and then compared with those characteristics of 20 NPF cases in China. The difference between Chinese and Japanese PF cases was investigated. The mean values of the characteristics from PF and NPF cases in China, including postprandial serum C-peptide concentration, plasma glucose concentration, and serum chloride were different. Compared to the 22 PF cases in Ja... Endocrine journals http://www.medworm.com/rss/comments.php?id=5080506 Wed, 27 Jul 2011 05:49:16 +0100 5080506 http://www.medworm.com/index.php?rid=5064146&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F961866k715k0p587%2F In conclusion, these results suggest that tubular damage is common in short-term T2DM patients. Urinary NGAL may be a promising early marker for monitoring renal impairment in short-term T2DM patients. Content Type Journal ArticlePages 1-7DOI 10.1007/s12020-011-9509-7Authors Wen-jin Fu, Department of Laboratory, Affiliated Houjie Hospital, Guangdong Medical College, Dongguan, 523945 Guangdong, ChinaShi-long Xiong, Department of Laboratory Medicine Centre, Southern Medical University, Guangzhou, 510515 Guangdong, ChinaYao-gao Fang, Department of Laboratory, Affiliated Houjie Hospital, Guangdong Medical College, Dongguan, 523945 Guangdong, ChinaShu Wen, Department of Obstetrics and Gynecology, Molecular and Human Genetics, Baylor College of Medicine, Houston, 77030 TX, USAMei-lian C... Endocrine journals http://www.medworm.com/rss/comments.php?id=5064146 Thu, 21 Jul 2011 18:09:15 +0100 5064146 http://www.medworm.com/index.php?rid=4999715&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr62888q4u0h04708%2F Abstract  Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated form of apelin-13. Apelin and APJ are expressed in the central nervous system, particularly in the hypothalamus and in many peripheral tissues. Apelin has been shown to be involved in the regulation of cardiovascular and fluid homeostasis, food intake, cell proliferation, and angiogenesis. In addition to be an ubiquitous peptide, apelin is also produced and secreted by adipocytes and thus considered as an adipokine. This has opened a new field of investigation establishing a link between apelin and metabolic disorders (obesity, type 2 diabetes, etc.) which is the focus of the present review... Endocrine journals http://www.medworm.com/rss/comments.php?id=4999715 Sat, 02 Jul 2011 05:43:51 +0100 4999715 http://www.medworm.com/index.php?rid=4999716&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F127v7033rq74765w%2F Abstract  Wolfram syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness), is a neurodegenerative disease with autosomal recessive inheritance with incomplete penetrance. DIDMOAD is a very rare disease with an estimated prevalence of 1 in 770,000 and it is believed to occur in 1 of 150 patients with juvenile-onset insulin-dependent diabetes mellitus. Additionally, WS may also present with different endocrine and metabolic abnormalities such as anterior and posterior pituitary gland dysfunction. This mini-review summarizes the variable presentation of WS and the need of screening for other metabolic and hormonal abnormalities, coexisting in this rare syndrome. Content Type Journal ArticlePages 1-4DOI 10.1007/s12020-011-950... Endocrine journals http://www.medworm.com/rss/comments.php?id=4999716 Sat, 02 Jul 2011 05:43:50 +0100 4999716 http://www.medworm.com/index.php?rid=4999717&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F75122ww2q251g892%2F Abstract  Accumulating evidence has suggested that transforming growth factor-beta 1 (TGF-β1) is a functional candidate for diabetic nephropathy (DN). However, association studies investigating the relationship of TGF-β1 gene T869C polymorphism and DN generate inconsistent results. To comprehensively clarify this issue, we performed a meta-analysis to evaluate the impact of the polymorphism on DN. We searched studies from PubMed and China National Knowledge Infrastructure (CNKI) through March 2011. Pooled ORs were calculated under allelic/additive/dominant/recessive/over-dominant genetic models. Nine studies with 1776 cases and 1740 controls were included. Our results indicated that C allele of T869C conferred a significantly increased risk of DN compared with T allele (OR... Endocrine journals http://www.medworm.com/rss/comments.php?id=4999717 Fri, 01 Jul 2011 17:43:30 +0100 4999717 http://www.medworm.com/index.php?rid=4999718&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flj72p632368v8023%2F This study analyzes the body composition of young adult women with Turner syndrome (TS) either treated or not treated with recombinant human growth hormone (rhGH) and compares them with a group of healthy women. Fifty-two non-treated TS patients (23.0 ± 5.8 years), 30 treated with rhGH (21.5 ± 1.5 years), and 133 healthy young adult women (22.9 ± 3.2 years) were evaluated regarding height (H) and weight, body mass index (BMI), brachial perimeter and tricipital cutaneous fold (fat and lean areas at the arm), sitting height (SRH = sitting height/H × 100), leg length (leg/H), waist and hip circumferences (waist/hip), and bioimpedance (percentages of water, lean mass, and fat mass). Age at start of rhGH therapy varied fr... Endocrine journals http://www.medworm.com/rss/comments.php?id=4999718 Fri, 01 Jul 2011 05:43:18 +0100 4999718 http://www.medworm.com/index.php?rid=4999719&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu6w0257tx8803229%2F We describe three patients showing unusual clinical presentations like trigeminal-neuralgia, skew deviation, hypomania associated with HE. The purpose of this article is to describe the patients with unusual clinical pictures of HE, something that has not been reported in elsewhere in medical literature. Content Type Journal ArticlePages 1-2DOI 10.1007/s12020-011-9506-xAuthors Yesim Yetimalar Beckmann, Neurology Department, Atatürk Training and Research Hospital, İzmir, TurkeyDilek Top, Neurology Department, Atatürk Training and Research Hospital, İzmir, TurkeyTamer Yiğit, Psychiatry Department, Atatürk Training and Research Hospital, İzmir, Turkey Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=4999719 Fri, 01 Jul 2011 05:43:17 +0100 4999719 http://www.medworm.com/index.php?rid=4999720&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkt1243377p604076%2F Abstract  Increased expression of adipocyte fatty acid binding protein (FABP4) is associated with type 2 diabetic, high triglycerides, increased lipid peroxidation, and inflammation markers. To study the expression of FABP4 mRNA in granulosa cells of patients with polycystic ovary syndrome (PCOS) and the impact of testosterone, insulin, and PPARγ agonist rosiglitazone on granulosa cells (GCs), and to investigate the relationship of serum FABP4 levels with clinical characteristics in patients with PCOS. The expression of FABP4 mRNA in GCs of patients with PCOS and normal controls were assayed by RT-PCR. We assessed the level of FABP4 mRNA after treatment with testosterone, insulin, and rosiglitazone in GCs from normal controls. Serum FABP4 were assayed from 96 patients with... Endocrine journals http://www.medworm.com/rss/comments.php?id=4999720 Fri, 01 Jul 2011 05:43:16 +0100 4999720 http://www.medworm.com/index.php?rid=4978105&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx437q56572416972%2F In conclusion, these results suggest that angiogenesis of human ACC maybe mediated by these proteins and they could represent selective targets for the molecularly targeted treatments of ACC. Content Type Journal ArticlePages 1-7DOI 10.1007/s12020-011-9502-1Authors Yun-ze Xu, Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No. 197, Ruijin Er Road, Shanghai, 200025 ChinaYu Zhu, Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No. 197, Ruijin Er Road, Shanghai, 200025 ChinaZhou-jun Shen, Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No. 197, Ruijin Er Road, Shanghai, 200025 ChinaJia-yan Sheng, Department of Urology, Ruijin Hospital, School of Medicine, Shangh... Endocrine journals http://www.medworm.com/rss/comments.php?id=4978105 Sat, 25 Jun 2011 05:42:24 +0100 4978105 http://www.medworm.com/index.php?rid=4970952&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbgx6646852628192%2F Abstract  Congenic BB rat strains carrying a SHR segment (D4Got41-Tacr1; 60.5–122.8 Mb; BB.4S) or a WOKW segment (D4Got41-Fabp1; 60.5–104.6 Mb; BB.4W) of chromosome 4 within the BB/OK background develop facets of the metabolic syndrome when compared with their parental BB/OK rats. To narrow down potential genes involved in the pathophysiology of metabolic syndrome, gene expression studies in adipose tissues of BB/OK, BB.4S, and BB.4W rats were initiated. Total RNA of subcutaneous and epididymal adipose tissue of BB/OK (n = 10), congenic BB.4S (n = 8), and BB.4W (n = 9) males at an age of 4 weeks was isolated. The mRNA expression of 92 genes involved in obesity, insulin resistance and other metabolic traits was measured by RT-P... Endocrine journals http://www.medworm.com/rss/comments.php?id=4970952 Fri, 24 Jun 2011 05:45:06 +0100 4970952 http://www.medworm.com/index.php?rid=4970953&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7711034180706633%2F Abstract  In 1994, 21 Belarus children presenting papillary thyroid cancer (PTC) diagnosed after the Chernobyl disaster, and already submitted to subtotal surgery, underwent thyroid re-operation and post-operative radioiodine (131I) therapy. All were re-evaluated after a 15-year follow-up, to evaluate the results of partial versus total thyroidectomy. Nineteen out of 21 children (mean age 9.2 years) had previously undergone a lobectomy. All cases underwent re-operation in 1994. Histology revealed a PTC in the residual lobe in three cases, three had lymph node metastases. After surgery, 20 patients underwent 131I therapy. The post-131I whole body scan was negative in seven cases, showed neck node metastases in five, lung metastases in three, multiple associated metastase... Endocrine journals http://www.medworm.com/rss/comments.php?id=4970953 Thu, 23 Jun 2011 06:12:10 +0100 4970953 http://www.medworm.com/index.php?rid=4970954&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd1n454421650w76h%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s12020-011-9494-xAuthors Melika Chihaoui, Department of Endocrinology, La Rabta Hospital, Tunis, TunisiaRania Hmaissi, Department of Endocrinology, La Rabta Hospital, Tunis, TunisiaMohamed Abid, Department of Endocrinology, Hedi Chaker Hospital, Sfax, TunisiaLarbi Chaieb, Department of Endocrinology, Farhat Hached Hospital, Sousse, TunisiaNéjib Ben Abdallah, Department of Endocrinology, Charles Nicolle Hospital, Tunis, TunisiaAbdeljelil Zaouche, Department of Surgery, Charles Nicolle Hospital, Tunis, TunisiaHabib Houman, Department of Internal Medicine, La Rabta Hospital, Tunis, TunisiaLilia Rokbani, Department of Internal Medicine, Habib Thameur Hospital, Tunis, TunisiaHedia Slimane, Department of Endocrinology, La Rabta Hospital, Tuni... Endocrine journals http://www.medworm.com/rss/comments.php?id=4970954 Tue, 21 Jun 2011 18:01:05 +0100 4970954 http://www.medworm.com/index.php?rid=4970955&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl43763540884028p%2F The objective was to establish a method to achieve the complete removal of tumors on the basis of the results of high-resolution magnetic resonance imaging (MRI), inferior petrosal sinus sampling (IPSS), and a surgical resection technique using frozen biopsy. Eighteen patients who underwent transsphenoidal surgery from 2004 to 2010 were included. High-resolution MRI and IPSS, multiple-staged resection, and tumor tissue identification in frozen sections (surgical and histological identification, SHI) were performed. All patients achieved surgical remission, as confirmed by 24 h urinary free cortisol excretion tests. Visible microlesions were identified on the initial MRI in 11 patients (61%). The SHI findings agreed with the MRI findings in 10 of the 11 patients (90.9%) and with ... Endocrine journals http://www.medworm.com/rss/comments.php?id=4970955 Tue, 21 Jun 2011 18:01:04 +0100 4970955 http://www.medworm.com/index.php?rid=4946820&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbjq14261w81q0w68%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s12020-011-9498-6Authors Eric J. Epstein, Division of Endocrinology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USAJing Chao, PGY-2, Internal Medicine Residency, Montefiore Medical Center, Bronx, USAChristian Keller, Montefiore Medical Center, Bronx, USAAntonio Cajigas, Montefiore Medical Center, Bronx, USA Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=4946820 Fri, 17 Jun 2011 10:56:01 +0100 4946820 http://www.medworm.com/index.php?rid=4946821&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F623u7vw34248q012%2F Abstract  To describe the coexistence of mutations of both the multiple endocrine neoplasia type 1 (MEN1) and type 2 (MEN2) genes in a large Italian family and evaluate if it could be associated with more aggressive clinical manifestations of the two syndromes. Blood samples were obtained for genetic and biochemical analyses. The RET gene exons (8, 10, 11, 13, 14, 15, 16, 18) and the MEN1 coding regions, including the exon–intron boundaries, were amplified by PCR and directly sequenced. We identified two germline mutations in the proband: the first one, K666M, located at the exon 11 of RET proto-oncogene and the second one, IVS4+1G>T, located in the MEN1 gene. The functional characterization of IVS4+1G>T variation, located in the splicing donor site of exon 4 of MEN1 ge... Endocrine journals http://www.medworm.com/rss/comments.php?id=4946821 Thu, 16 Jun 2011 05:49:57 +0100 4946821 http://www.medworm.com/index.php?rid=4904620&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1p6m206551q1360%2F Abstract  It remains elusive what factors induce growth without growth hormone (GWGH) in children after neurosurgery of brain tumors. Growth velocity and endocrinological data were compared between the patients with and without GWGH. We experienced three patients with GWGH (median, 12 years; 2 germinoma and 1 craniopharyngioma; three females; group 1) and 11 patients without (12 years; 8 craniopharyngioma, 2 germinoma and 1 medulloblastoma; 7 males; group 2) after neurosurgery. All patients in group 2 received GH replacement therapy. Growth velocity and endocrinological data were compared. Median height velocity was normal in group 1 (5.5 cm/year), but low in group 2 (2.2 cm/year), which improved after GH replacement therapy (7.0 cm/year). Median serum insuli... Endocrine journals http://www.medworm.com/rss/comments.php?id=4904620 Fri, 03 Jun 2011 05:56:15 +0100 4904620 http://www.medworm.com/index.php?rid=4904621&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fplw25781017406w0%2F Abstract  The key question answered by this study is whether it is possible to deliver a pharmacokinetic and pharmacodynamic duration of antidiuretic action long enough to ensure adequate antidiuresis with two daily administrations of desmopressin in patients with central diabetes insipidus (CDI). We studied the efficacy and safety of desmopressin i.v. in 13 CDI patients using two 3-way crossover designs, in the doses 30, 60, 125 ng, and 125, 250 and 500 ng. Duration of action, minimum output rate, max osmolality and average osmolality during action (AUC osmolality) were measured every 30 min for the first 2 h during the infusion, and then every hour or every second hour until the urine output rate was greater than 2 ml/kg/30 min. The duration o... Endocrine journals http://www.medworm.com/rss/comments.php?id=4904621 Mon, 30 May 2011 16:49:13 +0100 4904621 http://www.medworm.com/index.php?rid=4904622&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4800vu44057274u%2F Abstract  Vitamin D-dependent rickets type 1 (VDDR-I) is caused by mutation in CYP27B1. The glycine residue at codon 102 is not conserved between human (G102) and rodent (S102). G102E mutation results in 80% reduction in its enzymatic activity but PolyPhen predicts benign change. It is not known whether G102S has any damaging effect on 1α-hydroxylase activity. We investigated the effect of CYP27B1 G102S on its enzymatic activity and compared mutation prediction accuracy for all known CYP27B1 mutations among three free online protein prediction programs: PolyPhen, PolyPhen-2, and PSIPRED. G102S has no damaging effect on 1α-hydroxylase activity. G102D retained 30% enzymatic activity. All three programs correctly predicted damaging change for G102D. PolyPhen predicted benign c... Endocrine journals http://www.medworm.com/rss/comments.php?id=4904622 Sat, 21 May 2011 23:22:16 +0100 4904622 http://www.medworm.com/index.php?rid=4854717&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5795081066q4lv9%2F Abstract  Aberrant receptors have been implicated in the pathogenesis of several types of adrenal tumours. So far the presence of aberrant receptors has been investigated in patients with massively enlarged adrenals due to ACTH-independent macronodular adrenal hyperplasia (AIMAH) and unilateral adrenal adenomas associated with overt or subclinical Cushing’s syndrome. The likelihood of aberrant responses in patients presenting with bilateral adrenal incidentalomas (BI) presenting as discrete solitary bilateral adenomas has not been thoroughly addressed. This is an observational cross-sectional prospective study conducted in a secondary/tertiary care centre. We studied 33 patients; 28 with incidentally discovered bilateral discrete adrenal adenomas and five with massive bil... Endocrine journals http://www.medworm.com/rss/comments.php?id=4854717 Fri, 20 May 2011 05:55:11 +0100 4854717 http://www.medworm.com/index.php?rid=4854716&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F31v5ur235m6256x4%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s12020-011-9491-0Authors Koichiro Ogawa, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounen-cho, Nakagawa-ku, Nagoya, 454-8502 JapanMasanori Yoshida, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounen-cho, Nakagawa-ku, Nagoya, 454-8502 JapanYoshitaka Hayashi, Research Institute of Environmental Medicine, Nagoya University School of Medicine, Nagoya, JapanYoshiharu Murata, Research Institute of Environmental Medicine, Nagoya University School of Medicine, Nagoya, JapanMisaki Miyata, Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, 4-66 Shounen-cho, Nakagawa-ku, Nagoya, 454-8502 JapanYutaka Oiso, Department of Endocrinology and Diabetes, Nagoya University Sch... Endocrine journals http://www.medworm.com/rss/comments.php?id=4854716 Fri, 20 May 2011 05:55:11 +0100 4854716 http://www.medworm.com/index.php?rid=4854718&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq4161326vu276u54%2F This study was to evaluate the association between ADIPOQ gene variants and type 2 diabetes mellitus (T2DM). TaqMan® assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal control subjects (n = 1,107). Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs7649121AT and rs7649121AT/TT, compared with the AA genotype, were associated with a significantly decreased risk of T2DM [Adjusted OR (95% CI) = 0.79(0.66–0.95), 0.80(0.67–0.96), respectively]. In stratified analysis, rs2241767AG genotype increased the risk of T2DM in obesity group [Adjusted OR (95% CI) = 1.32(1.03–1.69)]. Patients with genotype AG/GG of rs2241767 had lower levels of serum adiponectin than those with the genotype AA ... Endocrine journals http://www.medworm.com/rss/comments.php?id=4854718 Thu, 19 May 2011 05:49:39 +0100 4854718 http://www.medworm.com/index.php?rid=4854719&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft5u0283163317517%2F In conclusion, this study suggests that diabetes mellitus may be associated with an increased prevalence of vertebral fractures in males with acromegaly. However, this effect seems to be relatively attenuated in the presence of persistent GH hypersecretion. Content Type Journal ArticlePages 1-7DOI 10.1007/s12020-011-9486-xAuthors Gherardo Mazziotti, Department of Medical and Surgical Sciences University of Brescia, Endocrine Service, Montichiari Hospital, Brescia, ItalyMonica Gola, Department of Medical and Surgical Sciences University of Brescia, Endocrine Service, Montichiari Hospital, Brescia, ItalyAntonio Bianchi, Department of Endocrinology, Pituitary Unit, Catholic University of Rome, 00168 Rome, ItalyTeresa Porcelli, Department of Medical and Surgical Sciences University of... Endocrine journals http://www.medworm.com/rss/comments.php?id=4854719 Wed, 18 May 2011 21:24:26 +0100 4854719 http://www.medworm.com/index.php?rid=4832341&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq230341242514175%2F Abstract  The prevalence of adrenal incidentaloma has increased with the increasing use of imaging techniques. While majority are benign adenoma, a small but significant minority may be primary adrenal carcinoma or have endocrine hyper secretion. Existing guidance suggests that excess catecholamine and cortisol secretion should be ruled out in all cases and excess aldosterone secretion should be ruled out in hypertensive patients. Repeat evaluation after a period of time is also suggested. We have reviewed the management of adrenal incidentaloma in a large district general hospital in the North West of England. Content Type Journal ArticlePages 1-3DOI 10.1007/s12020-011-9487-9Authors S. Bujawansa, Endocrine Unit, Wirral University Teaching Hospital Foundation Trust, Ar... Endocrine journals http://www.medworm.com/rss/comments.php?id=4832341 Thu, 12 May 2011 19:27:27 +0100 4832341 http://www.medworm.com/index.php?rid=4806659&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0kt9070l8rm5u098%2F Abstract  Insulin resistance is getting important in the course of type 1 diabetes mellitus. Visceral fat depot is associated with insulin resistance and assessment of epicardial fat thickness is a way of measuring visceral fat. The aim of the study was to measure epicardial adipose tissue (EAT) thickness and to determine its relationship with waist-hip-ratio (WHR) and estimated glucose disposal rate (eGDR) in adult type 1 diabetic patients. Thirty-six type 1 diabetic patients (aged 31 ± 8 years; Female/Male: 22/14) and 43 age, gender and BMI matched healthy controls were included. Fasting blood glucose (FBG), hemoglobin A1c, and lipid profiles were measured. Waist-hip-ratio (WHR) was calculated. Daily insulin dose/kg of patients were recorded and eGDR of al... Endocrine journals http://www.medworm.com/rss/comments.php?id=4806659 Sat, 07 May 2011 15:45:23 +0100 4806659 http://www.medworm.com/index.php?rid=4806660&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff6h7026386307525%2F Abstract  Iron liver excess is associated to biochemical and histological liver perturbations. Our aim was to know even if fresh garlic consumption can remediate these problems. Three groups of rats were utilized: control group A, iron overload group B and garlic and iron overload group C. Important morphological and biochemical modifications were obtained in group B rats comparatively to control group A. Indeed, body and liver weights and liver iron contents increased, respectively, by 12.5 ± 0.06%; 17 ± 0.25% and 35 ± 0.11% comparatively to controls. Radical cation scavenging ability in liver cytosol of group B rats was significantly low (54 ± 0,1%) in comparison to group A. Garlic consumption allowed the group C to achieve an in... Endocrine journals http://www.medworm.com/rss/comments.php?id=4806660 Sat, 07 May 2011 15:45:22 +0100 4806660 http://www.medworm.com/index.php?rid=4806661&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgp01431034065754%2F In conclusion, higher serum testosterone levels and Zn levels were associated with EE, and low scores of signs/symptoms of CMS were associated with higher Zn and nitric oxide levels. Content Type Journal ArticlePages 1-9DOI 10.1007/s12020-011-9482-1Authors Gustavo F. Gonzales, Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, PeruVilma Tapia, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, PeruManuel Gasco, Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, PeruJulio Rubio, Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lim... Endocrine journals http://www.medworm.com/rss/comments.php?id=4806661 Fri, 06 May 2011 16:25:01 +0100 4806661 http://www.medworm.com/index.php?rid=4806662&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft8147k7p5x4k3370%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s12020-011-9484-zAuthors Edvina Gregoric, Department of Nuclear Medicine, Hospital Izola, Izola, SloveniaJurji Avramovic Gregoric, Master of Childhood, Adolescent and Women’s Endocrine Health, Università di Messina, 98125 Messina, ItalyFabrizio Guarneri, Istituto di Dermatologia, Università di Messina, 98125 Messina, ItalySalvatore Benvenga, Master of Childhood, Adolescent and Women’s Endocrine Health, Università di Messina, 98125 Messina, Italy Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=4806662 Fri, 06 May 2011 05:53:37 +0100 4806662 http://www.medworm.com/index.php?rid=4806663&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr43k688867n1467v%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12020-011-9480-3Authors Tsung-Ying Ho, Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital at Linkou, No. 5, Fu-Hsing St., Kwei-Shan, Taoyuan, Taiwan, ROCMiaw-Jene Liou, The Section of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, TaiwanKun-Ju Lin, Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital at Linkou, No. 5, Fu-Hsing St., Kwei-Shan, Taoyuan, Taiwan, ROCTzu-Chen Yen, Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital at Linkou, No. 5, Fu-Hsing St., Kwei-Shan, Taoyuan, Taiwan, ROC Journal EndocrineOnline ISSN 1559-0100Print ISSN ... Endocrine journals http://www.medworm.com/rss/comments.php?id=4806663 Fri, 06 May 2011 05:53:35 +0100 4806663 http://www.medworm.com/index.php?rid=4806664&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F843200512206632x%2F Abstract  Sloan-Kettering virus gene product (Ski) is an unique nuclear pro-oncoprotein and belongs to the ski/sno proto-oncogene family. Ski plays multiple roles in a variety of cell types, it can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. Ski/SnoN are important transcription regulators of the transforming growth factor-β (TGF-β) superfamily and function mainly through heterodimers. Since TGF-β superfamily are key regulators of follicle development and it has been previously shown that SnoN is also vital to follicle development, this research was conducted to clarify the relationship between Ski expression and mouse follicular development, in ovaries of neonatal and gonadotropin-induced immature mice by immunoh... Endocrine journals http://www.medworm.com/rss/comments.php?id=4806664 Thu, 05 May 2011 05:43:43 +0100 4806664 http://www.medworm.com/index.php?rid=4790609&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1j785pkl18803273%2F Abstract  While oestrogen is recognized to play a key role in regulating growth, particularly in relation to epiphyseal fusion, the mechanisms that mediate its effects are still unclear. We utilized an in vitro model of chondrogenesis, the RCJ3.1C5.18 cell line, to explore the effect of oestrogen on this process. We demonstrated the presence of oestrogen receptors (ER) α and β in these cells, with increased abundance of both receptor sub-types evident as the cells differentiated. ERα localized to the nucleus, suggesting it was signalling by genomic pathways, while ERβ was seen predominantly in the cytoplasm, suggesting it may be utilizing non-genomic signalling. While exogenous oestrogen had no effect on proliferation or differentiation, we found some evidence for the e... Endocrine journals http://www.medworm.com/rss/comments.php?id=4790609 Wed, 04 May 2011 05:44:09 +0100 4790609 http://www.medworm.com/index.php?rid=4790608&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9k148061763t45x8%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s12020-011-9481-2Authors M. Zouhair Atassi, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USAPhilip R. Deitiker, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=4790608 Wed, 04 May 2011 05:44:09 +0100 4790608 http://www.medworm.com/index.php?rid=4806665&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq75735km73210773%2F Abstract  Since the clinical implementation of fine needle aspiration cytology (FNAC) to diagnose thyroid carcinoma, few patients remain misdiagnosed and little is known about their clinical outcomes. An observational retrospective study was carried out to analyse prognostic factors and follow-up of patients with differentiated thyroid carcinoma (DTC) not disclosed by FNAC before surgery, compared to a control group. From October 2003 to July 2010, 308 patients underwent surgery as treatment for nodular goitre and 53 had DTC. Cases were 12 subjects with DTC and benign (n = 7) or nondiagnostic (n = 5) FNAC. Controls were 39 subjects with DTC and suspicious (n = 19) or malignant (n = 20) FNAC. Prognostic factors, recurrence and survival r... Endocrine journals http://www.medworm.com/rss/comments.php?id=4806665 Wed, 04 May 2011 05:44:08 +0100 4806665 http://www.medworm.com/index.php?rid=4790610&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8g7805706p5r60u7%2F Abstract  Gender, age adjusted, population based reference ranges are necessary to use insulin-like growth factor 1 (IGF-1) as a diagnostic marker or for therapeutic monitoring in growth hormone (GH) related diseases. The aim of the present study was to describe the serum IGF-1 distribution and to calculate age and gender specific reference values for Caucasian adult population. A representative sample of 1002 male and 1039 female, totally 2041 participants aged above 18 years old was examined. The subjects suffering from diabetes mellitus, renal diseases, liver diseases, cancer, or diseases of pituitary gland were excluded by medical history, physical examination, and laboratory tests. The subjects were not using any drug that could affect IGF-1 levels. Body mass inde... Endocrine journals http://www.medworm.com/rss/comments.php?id=4790610 Tue, 03 May 2011 05:45:32 +0100 4790610 http://www.medworm.com/index.php?rid=4783169&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb409647374242577%2F Abstract  The number of pregnancies complicated by type 2 diabetes mellitus (T2DM) is growing; however, their clinical characteristics remain incomplete. We aimed to assess clinical characteristics, glycemic control, and selected pregnancy outcomes in pregestational T2DM from Poland and to compare them with those of T1DM. We analyzed 415 consecutive singleton pregnancies; among them, there were 70 women with T2DM and 345 with T1DM. As compared to T1DM patients, women with T2DM were older (mean age 33.1 years vs. 27.8, respectively), heavier before pregnancy (mean BMI 30.8 kg/m² vs. 23.9), and had a shorter duration of diabetes (mean 3.3 years vs. 11.4); ( P < 0.0001 for all comparisons). The gestational age at the first visit was higher in T2DM (... Endocrine journals http://www.medworm.com/rss/comments.php?id=4783169 Fri, 29 Apr 2011 05:43:11 +0100 4783169 http://www.medworm.com/index.php?rid=4783170&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg2l15114656407m1%2F Abstract  The aim of this article is to prospectively investigate the association of the liver enzyme γ-glutamyltransferase (GGT) with the development of diabetes and impaired glucose regulation (IGR) in a Chinese population. Seven hundred and sixty normoglycaemic subjects aged 40 years or older randomly selected from an urban community of Shanghai received a baseline investigation in May 2005. The participants were invited to receive a standard 75-g oral glucose tolerance test (OGTT) in November 2008. Incident diabetes and IGR were determined according to the 1999 WHO criteria. Serum GGT levels were significantly associated with incident diabetes or combined diabetes and IGR prospectively. After extensive adjustment, the diabetes risk was significantly increased with... Endocrine journals http://www.medworm.com/rss/comments.php?id=4783170 Wed, 27 Apr 2011 05:47:37 +0100 4783170 http://www.medworm.com/index.php?rid=4768804&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4mh2313h5r72561h%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s12020-011-9474-1Authors Hershel Raff, Endocrine Research Laboratory, Aurora St. Luke’s Medical Center, 2801 W KK River Pky Suite 245, Milwaukee, WI 53215, USASandra L. Ettema, Division of Otolaryngology/Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USADaniel C. Eastwood, Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI 53226, USAB. Tucker Woodson, Division of Sleep Medicine, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA Journal EndocrineOnline ISSN 1559-0100Print ISSN 1355-008X (Source: Endocrine) Endocrine journals http://www.medworm.com/rss/comments.php?id=4768804 Mon, 25 Apr 2011 16:44:29 +0100 4768804 http://www.medworm.com/index.php?rid=4768805&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb71211h057744l56%2F Abstract  Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho&nb... Endocrine journals http://www.medworm.com/rss/comments.php?id=4768805 Mon, 25 Apr 2011 16:44:27 +0100 4768805 http://www.medworm.com/index.php?rid=4748996&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F020555233061gg24%2F Abstract  Our objective is to outline the utility of adrenal venous sampling (AVS) with measurements of metanephrine to normetanephrine ratios for diagnostic localization of phaeochromocytoma in a patient with normal plasma levels of catecholamines. A 53-year-old-woman was referred for evaluation of recurrent pheochromocytoma following a right adrenalectomy 14 years earlier. Diagnosis of recurrent disease was established from elevations in plasma metanephrines with normal levels of catecholamines. Magnetic resonance imaging indicated two 1–2 cm masses in the right surgical bed and another 1-1.5 cm mass in the left adrenal. These masses were negative on 123I-metaiodobenzylguanidine scintigraphy. There was no evidence of a hereditary syndrome. We, therefore, c... Endocrine journals http://www.medworm.com/rss/comments.php?id=4748996 Thu, 21 Apr 2011 06:22:21 +0100 4748996 http://www.medworm.com/index.php?rid=4745291&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy571850491v47j52%2F In this study, we observed marked improvement in endothelial functions after L-T4 therapy in SH patients. We suggest that thyroid hormone replacement therapy may help to prevent atherosclerosis in this group of patients. Content Type Journal ArticlePages 1-5DOI 10.1007/s12020-011-9465-2Authors Fatma Alibaz Oner, Internal Medicine Department, Istanbul Education and Research Hospital, Istanbul, TurkeySelen Yurdakul, Cardiology Division, Istanbul Florence Nightingale Hospital, Istanbul, TurkeyEnder Oner, Coronary Intensive Care Unit, Istanbul Education and Research Hospital, Istanbul, TurkeyAyse Kubat Uzum, Endocrinology and Metabolism Department, Istanbul Education and Research Hospital, Istanbul, TurkeyMecdi Erguney, Internal Medicine Department, Istanbul Education and Research Hosp... Endocrine journals http://www.medworm.com/rss/comments.php?id=4745291 Wed, 20 Apr 2011 06:02:51 +0100 4745291 http://www.medworm.com/index.php?rid=4745290&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F087121571k7654w0%2F This study included 5,877 subjects with no previous history of thyroid malignancy referred to our PET/CT center (1,596 for cancer screening and 4,281 for primary staging or restaging purposes) from June 2006 to April 2009. All of the patients had at least 12 months of follow-up or were censored on the date of the last follow-up. The disease status was analyzed for correlation with the maximum standardized uptake value (SUVmax). Receiver operating characteristics (ROC) curves were constructed to determine the optimal cutoff values for SUVmax. In the screening group (n = 1,596), 55 patients (4%) had thyroid FDG uptake. Twenty-two subjects were referred for cytological or histological assessment and 4 (18%) were diagnosed with thyroid carcinoma. In the primary staging/res... Endocrine journals http://www.medworm.com/rss/comments.php?id=4745290 Wed, 20 Apr 2011 06:02:51 +0100 4745290 http://www.medworm.com/index.php?rid=4745292&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkh27m12u8uvp4r2u%2F In this study, we analyzed the expression of NIS in mouse, rat and human normal testis in different stages of development. By using a quantitative RT-PCR, Western blot and immunohistochemical analysis, NIS mRNA and protein were measured in both fetal and adult testicular tissues. NIS transcript was detected in both fetal and adult testis, although its expression levels were approximately 10-fold less than in thyroid gland. Western blot analysis and immunohistochemistry showed the presence of NIS protein in germinal and Leydig cells, but not in Sertoli cells with prevalent expression in the cytosol compartment of the cells. Our study demonstrates that NIS transcript and protein are expressed in normal testis. Further studies will demonstrate whether it may act as the transporter of ra... Endocrine journals http://www.medworm.com/rss/comments.php?id=4745292 Sat, 16 Apr 2011 05:51:14 +0100 4745292 http://www.medworm.com/index.php?rid=4745294&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj70h5v6200t585w9%2F This study aimed to investigate the value of repeat ultrasound-guided fine-needle aspiration (FNAC-US) in benign thyroid nodules and determine the ultrasound (US) predictors of malignancy in this group of nodules. The authors studied 35 of 143 nodules with initially benign cytological result who underwent serial re-biopsy (FNAC-US). By means of surgery, malignancy histology results were confirmed in 10 (28.5%) cases (G1) versus 25 (71.5%) benign nodules (G2). The clinical, lab, scintigraphyc, and US features were compared between the two groups to predict malignancy in thyroid nodules with initially benign cytological result. The cytological finding of 28/35 nodules were change to indeterminate cytology (Bethesda system category III or IV) at second and/or ≥third cytological study.... Endocrine journals http://www.medworm.com/rss/comments.php?id=4745294 Sat, 16 Apr 2011 05:51:13 +0100 4745294 http://www.medworm.com/index.php?rid=4745293&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft604758328523382%2F In conclusion, plasma asymmetric dimethylarginine level was higher in cases with abnormal glucose challenge test but normal OGTT as well as in gestational diabetics, compared to pregnant women with normal glucose tolerance. The elevated ADMA level in pregnant women with carbohydrate intolerance may possibly be due to elevated insulin level. Content Type Journal ArticlePages 1-6DOI 10.1007/s12020-011-9461-6Authors Ayse Cikim Sertkaya, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Inonu University, Malatya, 44315 TurkeyAyse Kafkasli, Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, TurkeyIlgin Turkcuoglu, Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, T... Endocrine journals http://www.medworm.com/rss/comments.php?id=4745293 Sat, 16 Apr 2011 05:51:13 +0100 4745293 http://www.medworm.com/index.php?rid=4745295&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F235l9738124731p5%2F This study confirmed clustering of established metabolic syndrome components and revealed additional associated cardiovascular disease risk factors, including lifestyle factors, exercise and total cholesterol, which should be targeted in prevention efforts. Content Type Journal ArticlePages 1-9DOI 10.1007/s12020-011-9466-1Authors Chung-Huang Tsai, Department of Family Medicine, Cheng Ching Hospital, No. 118, sec. 3, Chung-Kang Road, Taichung, 40764 Taiwan, ROCTsai-Chung Li, Graduate Institute of Biostatistics & Chinese Medicine Science, China Medical University & Hospital, No. 91, Hsueh-Shih Road, Taichung, 40402 Taiwan, ROCCheng-Chieh Lin, Department of Family Medicine, China Medical University & Hospital, No. 91, Hsueh-Shih Road, Taichung, 40402 Taiwan, ROCHsin-Sheng Tsay, Gradu... Endocrine journals http://www.medworm.com/rss/comments.php?id=4745295 Sat, 16 Apr 2011 05:51:12 +0100 4745295 http://www.medworm.com/index.php?rid=4726082&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu5584w136231108g%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12020-011-9464-3Authors Lola Weiss, Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital Ein Kerem, Hebrew University, Jerusalem, IsraelSteve Bernstein, QualTek Molecular Laboratories, Santa Barbara, CA, USARichard Jones, NextGen Sciences Ltd., Ann Arbor, MI, USARavi Amunugama, NextGen Sciences Ltd., Ann Arbor, MI, USADavid Krizman, Expression Pathology, Inc., Gaithersburg, MD, USALellean JeBailey, GeneGo Inc., St. Joseph, MI, USAOsnat Almogi-Hazan, Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital Ein Kerem, Hebrew University, Jerusalem, IsraelZhanna Yekhtin, Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University ... Endocrine journals http://www.medworm.com/rss/comments.php?id=4726082 Tue, 12 Apr 2011 06:54:44 +0100 4726082 http://www.medworm.com/index.php?rid=4726081&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl331111336l86657%2F Abstract  The renin–angiotensin system (RAS) is reportedly involved in chronic diabetic complications such as diabetic nephropathy, but changes of the RAS in diabetic skin remain unknown. The aim of this study was to investigate the expression of angiotensin (Ang) II and its type 1 (AT1) and type 2 (AT2) receptors in diabetic skin tissues, and explore the relationship between the local RAS and pathological changes of diabetic skin. Our results showed that thinning of epidermis, degeneration of collagen, fracture of dermal layer, and atrophy/disappearance of subcutaneous fat were observed in diabetic skin. The expression level of AngII was increased in diabetic skin tissues compared to that in controls. mRNA and protein expression of AT1 receptor were also increased while ... Endocrine journals http://www.medworm.com/rss/comments.php?id=4726081 Tue, 12 Apr 2011 06:54:44 +0100 4726081 http://www.medworm.com/index.php?rid=4726083&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32103mwl6q6gg8g1%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12020-011-9463-4Authors M. Haase, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, GermanyM. Anlauf, Department of Pathology, University Hospital Duesseldorf, Duesseldorf, GermanyM. Schott, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, GermanyS. Schinner, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, GermanyE. Kaminsky, Praxis für Humangenetik-Altona, Hamburg, GermanyW. A. Scherbaum, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, GermanyHolg... Endocrine journals http://www.medworm.com/rss/comments.php?id=4726083 Tue, 12 Apr 2011 06:54:43 +0100 4726083 http://www.medworm.com/index.php?rid=4710636&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn587703245462041%2F Abstract  Data on osteoporotic fractures in hyperprolactinemia are limited. An increased prevalence of radiological vertebral fractures was recently observed in women with prolactin (PRL)-secreting adenoma, whereas it is unknown whether this observation may reflect a more general increased risk of fractures in this disease and whether the prevalence of fractures in males is affected by gonadal status. Thirty-two males (median age 47 years, range: 22–79) with PRL-secreting pituitary adenoma (10 with microadenoma and 22 with macroadenoma) and 64 control males, with normal PRL values and with comparable age to patients with hyperprolactinemia, were evaluated for vertebral fractures by a morphometric approach and for bone mineral density (BMD) by a dual-energy X-ray abso... Endocrine journals http://www.medworm.com/rss/comments.php?id=4710636 Sat, 09 Apr 2011 15:48:52 +0100 4710636 http://www.medworm.com/index.php?rid=4687009&cid=s_35957_15_f&fid=35957&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq73055836346k524%2F We examined the role of allopregnanolone on in vitro LHRH and glutamate release from mediobasal hypothalamus and anterior preoptic area of ovariectomized rats with estrogen and progesterone replacement. Moreover, we evaluated whether the neurosteroid might act through modulation of NMDA receptors. Allopregnanolone induced an increase in LHRH release. This effect was reversed when the NMDA receptors were blocked by the NMDA antagonist 2-amino-7-phosphonoheptanoic acid (AP-7) indicating that this neurosteroid would interact with NMDA receptors. Moreover allopregnanolone induced an augment in K+ evoked [3H]-glutamate release from mediobasal hypothalamus-anterior preoptic area explants and this effect was also reversed when NMDA receptors were blocked with AP-7. These results suggest an ... Endocrine journals http://www.medworm.com/rss/comments.php?id=4687009 Thu, 31 Mar 2011 17:36:22 +0100 4687009