MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Endokrynologia Polska' source. Sun, 05 Feb 2012 15:01:35 +0100 http://www.medworm.com/index.php?rid=5478264&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22120181%26dopt%3DAbstract Authors: Kos-Kudła B PMID: 22120181 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478264 Wed, 07 Dec 2011 15:12:02 +0100 5478264 http://www.medworm.com/index.php?rid=5478261&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144214%26dopt%3DAbstract Conclusions: This study did not confirm that VDR polymorphism can modulate therapeutic outcome of FHA girls subjected to the hormonal treatment. Nonetheless, this study confirmed the effectiveness of EP therapy in the simultaneous treatment of menstrual disorders and the normalisation of bone mineral density in FHA patients. (Pol J Endocrinol 2011; 62 (6): 492-498). PMID: 22144214 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478261 Wed, 07 Dec 2011 15:12:02 +0100 5478261 http://www.medworm.com/index.php?rid=5478260&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144215%26dopt%3DAbstract Conclusion: This study demonstrates that weight reduction after successful lifestyle intervention results in improvements of blood inflammatory markers in obese children and adolescents. (Pol J Endocrinol 2011; 62 (6): 499-505). PMID: 22144215 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478260 Wed, 07 Dec 2011 15:12:02 +0100 5478260 http://www.medworm.com/index.php?rid=5478259&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144216%26dopt%3DAbstract Conclusion: Our study confirms that obesity is a risk factor for vitamin D deficiency. Hypovitaminosis D, common in obese adolescents at risk for type 2 diabetes (older age, puberty, acanthosis nigricans) is associated with worse insulin resistance. (Pol J Endocrinol 2011; 62 (6): 506-511). PMID: 22144216 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478259 Wed, 07 Dec 2011 15:12:02 +0100 5478259 http://www.medworm.com/index.php?rid=5478258&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144217%26dopt%3DAbstract Conclusion: This study shows that LA is a safe, effective, and well-tolerated procedure despite the hormonal activity of the removed lesions. Minimal invasive surgery may be recommended as the 'gold standard' in the treatment of both functioning and non-functioning benign tumours of the adrenal gland. (Pol J Endocrinol 2011; 62 (6): 512-516). PMID: 22144217 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478258 Wed, 07 Dec 2011 15:12:02 +0100 5478258 http://www.medworm.com/index.php?rid=5478257&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144218%26dopt%3DAbstract Conclusions: Among patients treated with interferon due to CVH type C, there is a risk of the development of ATI or the exacerbation of an existing one. There is no significant difference in ATI presentation in relation to the type of IFN-α used for treatment. (Pol J Endocrinol 2011; 62 (6): 517-522). PMID: 22144218 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478257 Wed, 07 Dec 2011 15:12:02 +0100 5478257 http://www.medworm.com/index.php?rid=5478256&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144219%26dopt%3DAbstract Conclusions: Hyperthyroidism and hypothyroidism induce changes of the plasma concentration of NT-pro-BNP. Although both exogenous L-thyroxine and antithyroid drugs restored thyroid function, only the former drug changed plasma NT-pro-BNP content. The thyrometabolic state of a patient should always be taken into consideration when NT-pro-BNP is assessed as a marker of cardiac dysfunction. (Pol J Endocrinol 2011; 62 (6): 523-528). PMID: 22144219 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478256 Wed, 07 Dec 2011 15:12:02 +0100 5478256 http://www.medworm.com/index.php?rid=5478255&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144220%26dopt%3DAbstract Conclusions: MaPRL is not a significant clinical problem in the studied population. However, in patients with hyperprolactinaemia, especially non-organic, screening for macroprolactinaemia should be performed. The effectiveness of the precipitation and ultrafiltration methods for detecting MaPRL is comparable in functional hyperprolactinaemia, but the usefulness of ultrafiltration in patients with pituitary adenoma requires further examination. (Pol J Endocrinol 2011; 62 (6): 529-536). PMID: 22144220 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478255 Wed, 07 Dec 2011 15:12:02 +0100 5478255 http://www.medworm.com/index.php?rid=5478254&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144221%26dopt%3DAbstract Effects of oestrogen deficiency on bone mineralisation in girls during "adolescent crisis". Endokrynol Pol. 2011;62(6):538-46 Authors: Sowińska-Przepiera E, Andrysiak-Mamos E, Jarząbek-Bielecka G, Friebe Z, Syrenicz A Abstract Puberty is a critical bone mineralisation period, and peak bone mass attained by adolescent girls is one of the most significant predictive factors for postmenopausal osteoporosis. Adolescent girls' peak bone mass depends on genetic factors as well as on general condition, nutritional status and body mass; lifestyle is also important, along with physical exercise and the use of prescription drugs. Additionally, hormones, including oestrogens, play an important role during pubertal accumulation of bone mass. Therefore, oestrogen deficiency during pub... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478254 Wed, 07 Dec 2011 15:12:02 +0100 5478254 http://www.medworm.com/index.php?rid=5478253&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144222%26dopt%3DAbstract This article presents a case of late MEN 2B diagnosis despite the presence of clinical symptoms suggestive of Multiple Endocrine Neoplasia observed from early childhood. (Pol J Endocrinol 2011; 62 (6): 548-553). PMID: 22144222 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478253 Wed, 07 Dec 2011 15:12:02 +0100 5478253 http://www.medworm.com/index.php?rid=5478252&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144223%26dopt%3DAbstract Authors: Malicka J, Swirska J, Nowakowski A Abstract In the majority of cases, acromegaly is sporadic. However, it can also occur in a familial setting as a component of MEN-1, MEN-4, Carney complex (CNC) or as the extremely rare syndrome of isolated familial somatotropinoma (IFS), the latter belonging to familial isolated pituitary adenomas (FIPA). The diagnosis of IFS is based on the recognition of acromegaly/gigantism in at least two family members, given that the family is not affected by MEN-1, MEN-4 or CNC. The authors present a case study of two sisters: a 56 year-old patient (case no. 1) and a 61 year-old patient (case no. 2). In both sisters, acromegaly was recognised in the course of pituitary macroadenoma. Neither of the sisters showed features of MEN-1, MEN-4 or Carney... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478252 Wed, 07 Dec 2011 15:12:02 +0100 5478252 http://www.medworm.com/index.php?rid=5478251&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144224%26dopt%3DAbstract This article presents the role of the hypothalamus in reproduction, the definition of hypogonadotropic hypogonadism (HH), and the causes of acquired and syndromic HH and idiopathic HH (IHH). The authors present a short review of major causes of acquired HH, but most of the causes of IHH will not be discussed because they do not fall within the scope of the article. More attention is devoted to idiopathic HH, especially the genetic basis of IHH. Also presented in the article are clinical criteria of CHARGE syndrome. Later, the article discusses the clinical presentation, establishing the diagnosis, and management of IHH. The article ends with a brief overview of nutritional hypothalamic dysfunction and athletic amenorrhea. (Pol J Endocrinol 2011; 62 (6): 560-567). PMID: 22144224 [PubMed... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5478251 Wed, 07 Dec 2011 15:12:02 +0100 5478251 http://www.medworm.com/index.php?rid=5427037&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069098%26dopt%3DAbstract Conclusion: Dopamine D2 receptors are revealed by means of immunohistochemistry in the majority of NET. They exhibit cytoplasmic and/or nuclear localisations, the latter being possibly linked to a higher grade of malignancy, and are often co-expressed with somatostatin receptors (mostly with subtypes1 and 5). (Pol J Endocrinol 2011; 62 (5): 388-391). PMID: 22069098 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427037 Sun, 20 Nov 2011 03:42:05 +0100 5427037 http://www.medworm.com/index.php?rid=5427036&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069099%26dopt%3DAbstract Conclusions: NETs (90)Y-DOTATATE therapy results in symptomatic relief and tumour mass reduction. The mild critical organ toxicity does not limit the PRRT of NETs. (Pol J Endocrinol 2011; 62 (5): 392-400). PMID: 22069099 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427036 Sun, 20 Nov 2011 03:42:05 +0100 5427036 http://www.medworm.com/index.php?rid=5427035&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069100%26dopt%3DAbstract Conclusions: The level of IGF-1 prior to surgery and prior to SSLAR treatment is a better predictor of the treatment outcome than hGH. Octreotide LAR was most effective over the first 12 months of treatment. No further significant decrease of hGH or IGF-1 levels was observed past this period. (Pol J Endocrinol 2011; 62 (5): 401-408). PMID: 22069100 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427035 Sun, 20 Nov 2011 03:42:05 +0100 5427035 http://www.medworm.com/index.php?rid=5427034&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069101%26dopt%3DAbstract Conclusions: Hyperthyroidism is associated with a tendency toward hypercoagulation and hyperfibrinolysis. The changes observed in plasma fibrinogen and D-dimers levels are reversible. Fibrinogen level decreases within reference range and D-dimers level decreases almost to the upper reference range. They depend on severity and autoimmunity of the underlying thyroid disease and may be modified by restoring euthyroidism. (Pol J Endocrinol 2011; 62 (5): 409-415). PMID: 22069101 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427034 Sun, 20 Nov 2011 03:42:05 +0100 5427034 http://www.medworm.com/index.php?rid=5427033&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069102%26dopt%3DAbstract Conclusion: Less than one third of pregnant women participated in the thyroid function screening. Place of living, education level, and age were the main factors influencing the attendance rate. (Pol J Endocrinol 2011; 62 (5): 416-420). PMID: 22069102 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427033 Sun, 20 Nov 2011 03:42:05 +0100 5427033 http://www.medworm.com/index.php?rid=5427032&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069103%26dopt%3DAbstract Conclusion: Thyroid autoimmunity may have some effects on hyperlipidaemia and abdominal obesity independent of thyroid function. (Pol J Endocrinol 2011; 62 (5): 421-428). PMID: 22069103 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427032 Sun, 20 Nov 2011 03:42:05 +0100 5427032 http://www.medworm.com/index.php?rid=5427031&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069104%26dopt%3DAbstract Conclusion: Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients. (Pol J Endocrinol 2011; 62 (5): 429-435). PMID: 22069104 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427031 Sun, 20 Nov 2011 03:42:05 +0100 5427031 http://www.medworm.com/index.php?rid=5427030&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069105%26dopt%3DAbstract Conclusions: Interactions between HLA and 5'VNTR genotype are not of multiplicative character. Class I homozygosity at 5'VNTR is a significant risk factor of T1DM and acts independently from HLA haplotype in determining the actual risk of diabetes in children. (Pol J Endocrinol 2011; 62 (5): 436-442). PMID: 22069105 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427030 Sun, 20 Nov 2011 03:42:05 +0100 5427030 http://www.medworm.com/index.php?rid=5427029&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069106%26dopt%3DAbstract Authors: Kajdaniuk D, Marek B, Borgiel-Marek H, Kos-Kudła B Abstract Angiogenesis is an important component of many physiological processes, such as the female sexual cycle, placenta formation, the processes of growth and differentiation of tissues, and reparative processes including wound healing, fracture repair, and liver regeneration. The formation of new blood vessels during angiogenesis and vasculogenesis allows the growth and functioning of multicellular organisms. Pathological angiogenesis most commonly occurs in ischaemic, inflammatory and neoplastic diseases. Conditions in the pathogenesis of which angiogenesis plays an important role are sometimes labelled angiogenic diseases. To date, a number of pro-and anti-angiogenic factors have been defined. VEGF is the only speci... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427029 Sun, 20 Nov 2011 03:42:05 +0100 5427029 http://www.medworm.com/index.php?rid=5427028&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069107%26dopt%3DAbstract Authors: Kajdaniuk D, Marek B, Foltyn W, Kos-Kudła B Abstract Endocrine glands are well vascularised and the structure of their vessels facilitates the exchange of various substances, including hormones. These glands are a frequent experimental model in research on VEGF and angiogenesis. VEGF participates in the pathogenesis of diabetes. Diabetic nephropathy is in essence a microvascular disease that develops as a result of a confluence of haemodynamic and metabolic perturbations. Diabetic retinopathy is the commonest microvascular complication of diabetes mellitus and is the leading cause of blindness. In diabetic retinopathy, ischaemic states, and hence tissue hypoxia and angiogenesis, take place. The participation of angiogenesis and VEGF in the pathogenesis of neoplastic disea... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427028 Sun, 20 Nov 2011 03:42:05 +0100 5427028 http://www.medworm.com/index.php?rid=5427027&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069108%26dopt%3DAbstract We report the case of an 82 year-old man with diabetes mellitus type 2 and a history of steroid treatment who presented with severe odynophagia and dysphagia associated with fever, chills, sore throat and right ear pain. Based on the clinical picture, radiological studies, thyroid cytology, blood and thyroid aspirate culture, suppurative thyroiditis caused by Salmonella enteritidis was diagnosed. The patient was successfully treated with antibiotics and surgical drainage. (Pol J Endocrinol 2011; 62 (5): 466-470). PMID: 22069108 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427027 Sun, 20 Nov 2011 03:42:05 +0100 5427027 http://www.medworm.com/index.php?rid=5427026&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22069109%26dopt%3DAbstract This article provides a review of the current literature on osteoporosis after transplantation, and the treatment options for this serious illness. (Pol J Endocrinol 2011; 62 (5): 472-485). PMID: 22069109 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5427026 Sun, 20 Nov 2011 03:42:05 +0100 5427026 http://www.medworm.com/index.php?rid=5180183&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879467%26dopt%3DAbstract Conclusions: Comparative analysis of examined parameters of FRAX between people with and without fractures showed considerable differences only in age and AR-10 m.o.fx. This doubled in people with previous fractures (ca. 18% vs. 9%) and AR-10 h.fx. (ca. 5% vs. 2.5%). The "middle" area between the average population risks (AR-10 m.o.fx. 11% and AR-10 h.fx. 3%) and the risks in patients with fractures (AR-10 m.o.fx. 18% and AR-10 h.fx. 9%) could work as an indicator: below those values the risk is low and no treatment is required; above those values, the risk is high, and intervention is necessary; the middle area implies a BMD examination and reassessment of the fracture risk. (Pol J Endocrinol 2011; 62 (4): 290-298). PMID: 21879467 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180183 Thu, 01 Sep 2011 20:00:04 +0100 5180183 http://www.medworm.com/index.php?rid=5180182&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879468%26dopt%3DAbstract Conclusions: The results of our study suggest that interleukin-6 plays a considerable role in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in oestrogen-deficient women. (Pol J Endocrinol 2011; 62 (4): 299-302). PMID: 21879468 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180182 Thu, 01 Sep 2011 20:00:04 +0100 5180182 http://www.medworm.com/index.php?rid=5180181&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879469%26dopt%3DAbstract Conclusions: CLT cases should be evaluated more carefully in terms of malignancy. If a nodule is detected on thyroiditis, the minimal surgical intervention should be lobectomy. Total thyroidectomy should be considered as preferable to subtotal thyroidectomy because of its many advantages such as controlling thyroiditis, removing the probability of reoperation, and hormonal stability. (Pol J Endocrinol 2011; 62 (4): 303-308). PMID: 21879469 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180181 Thu, 01 Sep 2011 20:00:04 +0100 5180181 http://www.medworm.com/index.php?rid=5180180&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879470%26dopt%3DAbstract Conclusions: The promotion of iodine supplementation to pregnant women should be augmented at each level of contact with medical staff. Medical staff should be reminded about such promotion at each level of medical care and training (general practitioner, obstetrics/gynaecology specialist, endocrinologist, postgraduate training). (Pol J Endocrinol 2011; 62 (4): 309-315). PMID: 21879470 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180180 Thu, 01 Sep 2011 20:00:04 +0100 5180180 http://www.medworm.com/index.php?rid=5180179&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879471%26dopt%3DAbstract Conclusions: Determining MetS or HTGW helps identify those with increased cardiovascular risk. (Pol J Endocrinol 2011; 62 (4): 316-323). PMID: 21879471 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180179 Thu, 01 Sep 2011 20:00:04 +0100 5180179 http://www.medworm.com/index.php?rid=5180178&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879472%26dopt%3DAbstract Conclusion: These results indicate that systolic and diastolic BP are as strong as MAP in predicting progression to diabetes. Increased BP may help identify FDRs of patients with type 2 diabetes at high risk for diabetes who are candidates for BP control. (Pol J Endocrinol 2011; 62 (4): 324-330). PMID: 21879472 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180178 Thu, 01 Sep 2011 20:00:04 +0100 5180178 http://www.medworm.com/index.php?rid=5180177&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879473%26dopt%3DAbstract Conclusions: The results presented in this paper suggest that higher 11betaHSD1 gene expression in the WAT is associated with higher body and adipose tissue mass. Moreover, our results suggest that oestradiol can modulate 11-beta-HSD1 gene expression in the WAT of rats. (Pol J Endocrinol 2011; 62 (4): 331-334). PMID: 21879473 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180177 Thu, 01 Sep 2011 20:00:04 +0100 5180177 http://www.medworm.com/index.php?rid=5180176&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879474%26dopt%3DAbstract Authors: Kosowicz J, Baumann-Antczak A, Zamysłowska H, Sowiński J Abstract In recent years we have performed more than 1,000 radioimmunoassays of ghrelin and obestatin. In these assays, we have encountered several technological obstacles. Another difficulty was the enormous discrepancy of plasma ghrelin results published by different authors. The aim of this article is to comment on these problems. Not all peptides of the hypothalamus and intestines are present in blood circulation. Several neuropeptides do not cross the blood-brain barrier, and several gastrointestinal peptides are present in extremely low concentrations in the blood. That requires time-consuming and laborious extraction. In these procedures, considerable amounts of peptides may be lost. In addition, these pepti... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180176 Thu, 01 Sep 2011 20:00:04 +0100 5180176 http://www.medworm.com/index.php?rid=5180175&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879475%26dopt%3DAbstract Authors: Sworczak K, Wiśniewski P Abstract Although vitamin deficiencies are uncommon in Poland or other developed countries, many patients take vitamin supplements. Despite the widespread availability of vitamins and the universal belief that vitamins offer health benefits, few publications have addressed their role in the prevention and treatment of thyroid diseases. There is some evidence to suggest that the administration of vitamins with anti-oxidant properties in patients with hyperthyroidism can decrease the severity of clinical symptoms, and that vitamin D supplementation can have a beneficial effect on the bone system for these patients. It has also been suggested that patients with autoimmune thyroid diseases should be periodically screened for vitamin B12 deficiency. Th... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180175 Thu, 01 Sep 2011 20:00:04 +0100 5180175 http://www.medworm.com/index.php?rid=5180174&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879476%26dopt%3DAbstract We report two cases of primary hyperparathyroidism in children diagnosed at the Department of Endocrinology and Diabetes (EU and D) in the Children's Hospital (ChH), Kielce. The clinical course of the disease in these cases was fundamentally dissimilar, which confirms the observation that this rare endocrinopathy in children presents various clinical profiles, leading to diagnostic difficulties. In the first case, the severe course of PHPT was observed with signs suggesting a hypercalcemic crisis. In the second case, the patient was in a good condition with a mild hypercalcemia and symptoms limited to the skeleton, due to early identification of the disease. We believe these cases indicate the significant role of calcemia determination as a screening test in the diagnosis of PHPT, includin... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180174 Thu, 01 Sep 2011 20:00:04 +0100 5180174 http://www.medworm.com/index.php?rid=5180173&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879477%26dopt%3DAbstract We report the case of a female patient with Riedel's thyroiditis displaying clinical, laboratory and radiological traits of both diseases. A 44 year-old Caucasian female was diagnosed with hypothyroidism. A fine-needle aspiration biopsy was performed; the findings were suggestive of an exacerbated chronic inflammatory process. However, a small lymphocyte-derived malignancy could not be ruled out with certainty, and so the patient was referred for elective thyroidectomy. The microscopic features of both specimens did not meet the criteria of Hashimoto's thyroiditis. The immunohistochemical studies revealed few scattered B lymphocytes (CD20 positive) and numerous scattered T lymphocytes (CD3 positive). Finally, Riedel's thyroiditis with an intense inflammatory infiltrate composed of lymphocy... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180173 Thu, 01 Sep 2011 20:00:04 +0100 5180173 http://www.medworm.com/index.php?rid=5180172&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879478%26dopt%3DAbstract We report a type 1 diabetic patient with a liver abscess mimicking metastatic liver disease who was successfully treated with percutaneous drainage and antibiotic administration; culture from blood was positive for Yersinia enterocolitica, but drainage material from the liver abscess did not yield a positive result for Yersinia enterocolitica. Although the prognosis is not good in such cases, with high mortality rates, our patient recovered from the disease with appropriate treatment. (Pol J Endocrinol 2011; 62 (4): 357-360). PMID: 21879478 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180172 Thu, 01 Sep 2011 20:00:04 +0100 5180172 http://www.medworm.com/index.php?rid=5180171&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21879479%26dopt%3DAbstract Authors: Hubalewska-Dydejczyk A, Lewiński A, Milewicz A, Radowicki S, Poręba R, Karbownik-Lewińska M, Kostecka-Matyja M, Trofimiuk-Müldner M, Pach D, Zygmunt A Abstract The management of thyroid disorders during pregnancy is one of the most frequently disputed problems in modern endocrinology. It is widely known that thyroid dysfunction may result in subfertility, and, if inadequately treated during pregnancy, may cause obstetrical complications and influence fetal development. The 2007 Endocrine Society Practice Guideline endorsed with the participation of the Latino America Thyroid Association, the American Thyroid Association, the Asia and Oceania Thyroid Association and the European Thyroid Association, greatly contributed towards uniformity of the management of thyroid dis... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5180171 Thu, 01 Sep 2011 20:00:04 +0100 5180171 http://www.medworm.com/index.php?rid=5012245&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717402%26dopt%3DAbstract Conclusions: Since 5% of our Graves' disease patients developed severe GO following radioiodine treatment, an association between radioiodine therapy and severe ophthalmopathy cannot be excluded. IL-6 and IL-2 concentrations remained elevated after glucocorticoid therapy. (Pol J Endocrinol 2011; 62 (3): 214-219). PMID: 21717402 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012245 Tue, 12 Jul 2011 13:00:02 +0100 5012245 http://www.medworm.com/index.php?rid=5012244&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717403%26dopt%3DAbstract Conclusions: Hypothyroidism decreases the level of erythrocytes oxidation/reduction balance by diminishing oxidative lipids damage and by decreasing the activity of antioxidative enzymes, but not by changes in the level of antioxidant vitamins. (Pol J Endocrinol 2011; 62 (3): 220-223). PMID: 21717403 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012244 Tue, 12 Jul 2011 13:00:02 +0100 5012244 http://www.medworm.com/index.php?rid=5012243&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717404%26dopt%3DAbstract Conclusions: FISH analysis is a convenient screening technique, but in the presented family it failed to detect the deletion. Therefore, in the face of a distinctive manifestation of KS, a subsequent molecular assay should be introduced. The MLPA is a useful technique for differential diagnosis in patients with HH combined with smell impairment. (Pol J Endocrinol 2011; 62 (3): 224-229). PMID: 21717404 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012243 Tue, 12 Jul 2011 13:00:02 +0100 5012243 http://www.medworm.com/index.php?rid=5012242&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717405%26dopt%3DAbstract Conclusions: Analysing the clinical picture of the examined population of patients with NPKN enabled us to specify symptoms of disease which were significant for diagnosis, and which helped differentiate NPKN from other endocrinopathies involving hyperandrogenism, including in particular PCOS. Taking everything into consideration, non-standard hypertrophy of the adrenal cortex is a rare cause of hyperandrogenism in women of procreative age. Intense hirsutism and features of virilisation presenting as hypertrophy of the clitoris predominate in the clinical picture of non-standard hypertrophy of the adrenal cortex. The laboratory confirmation of diagnosis of NPKN constitutes the analysis of the 17-OHP level in blood in the ACTH stimulation test. The analyses of free testosterone and its unbo... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012242 Tue, 12 Jul 2011 13:00:02 +0100 5012242 http://www.medworm.com/index.php?rid=5012241&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717406%26dopt%3DAbstract Conclusion: The Rotterdam prevalence estimates were double those obtained with the NIH criteria. This study can be used for international comparisons because it was conducted on a representative sample of females using different criteria for the definition of PCOS. (Pol J Endocrinol 2011; 62 (3): 238-242). PMID: 21717406 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012241 Tue, 12 Jul 2011 13:00:02 +0100 5012241 http://www.medworm.com/index.php?rid=5012240&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717407%26dopt%3DAbstract Conclusions: Elevated levels of vWF:Ag and E selectin in PCOS women suggest endothelial dysfunction in this group of patients. Glucose and triglyceride are significant factors affecting endothelial function in PCOS. (Pol J Endocrinol 2011; 62 (3): 243-248). PMID: 21717407 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012240 Tue, 12 Jul 2011 13:00:02 +0100 5012240 http://www.medworm.com/index.php?rid=5012239&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717408%26dopt%3DAbstract Conclusion: This study shows that although in this area with a high humidity climate, seasonal variation of vitamin D is statistically significant, the prevalence of Vitamin D insufficiency is as high in summer as in winter. (Pol J Endocrinol 2011; 62 (3): 249-251). PMID: 21717408 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012239 Tue, 12 Jul 2011 13:00:02 +0100 5012239 http://www.medworm.com/index.php?rid=5012238&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717409%26dopt%3DAbstract Conclusions: The study indicates that melatonin supplementation maintains the liver glycogen levels that decrease in acute swimming exercise, while induced diabetes prevents this maintenance effect in rats. (Pol J Endocrinol 2011; 62 (3): 252-255). PMID: 21717409 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012238 Tue, 12 Jul 2011 13:00:02 +0100 5012238 http://www.medworm.com/index.php?rid=5012237&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717410%26dopt%3DAbstract Authors: Tucholski K, Otto-Buczkowska E The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with adipose tissue mass. Leptin was first described as acting on the satiety centre in the hypothalamus through specific receptors (ob-R) to restrict food intake and enhance energy expenditure. Leptin plays a crucial role in the maintenance of body weight and glucose homeostasis hrough central and peripheral pathways, including regulation of insulin secretion by pancreatic b cells. Leptin may also directly affect the metabolism and function of peripheral tissues. Leptin has been implicated in causing peripheral insulin resistance by attenuating insulin action, and perhaps insulin signalling, in various insulin-responsive cell types. Research has demonstrat... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012237 Tue, 12 Jul 2011 13:00:02 +0100 5012237 http://www.medworm.com/index.php?rid=5012236&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717411%26dopt%3DAbstract Authors: Fichna P, Fichna M, Zurawek M, Nowak J Hypogonadotropic hypogonadism (HH) is characterised by delayed puberty and infertility. Congenital HH comprises Kallmann syndrome with hypo-/anosmia and idiopathic HH (IHH). The genetic origin remains unknown in most cases, but the defective GnRH receptor gene (GNRHR) accounts for a considerable proportion of IHH. Here we describe a pair of siblings diagnosed with IHH. Aged 17 years, the boy was referred because of short stature (162 cm) and overweight (62.5 kg). He presented no signs of puberty, bone age of 14.5 years and insulin resistance. His sister, aged 16 years, also displayed delayed puberty. She was 166 cm tall and weighed 52 kg; her bone age was 12.5 years. Pelvic ultrasonography showed an infantile uterus and fibrous ovaries. I... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012236 Tue, 12 Jul 2011 13:00:02 +0100 5012236 http://www.medworm.com/index.php?rid=5012235&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717412%26dopt%3DAbstract We report a case of Carney Complex that was referred for adrenalectomy. The procedure was uneventful and the patient was well at discharge. The adrenal pathology showed numerous black nodules measuring less than 2mm in diameter. This feature was pathognomonic of primary pigmented nodular adrenocortical disease. (Pol J Endocrinol 2011; 62 (3): 268-270). PMID: 21717412 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012235 Tue, 12 Jul 2011 13:00:02 +0100 5012235 http://www.medworm.com/index.php?rid=5012234&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717413%26dopt%3DAbstract Authors: Mert M, Kocabay G Without treatment, Cushing's disease has significant morbidity and mortality. Where a surgical approach may not be feasible, or is refused by the patient, medical therapy becomes the only option. In this case report, we discuss the effects of two years of ketoconazole treatment on diabetes regulation and insulin resistance in a patient reluctant to agree to surgery. A 62 year-old female patient with uncontrolled type 2 diabetes mellitus was investigated. Cushing's disease was confirmed by the results of high urine free cortisol level and dexamethasone suppression tests. We discuss the effects of two years of 600 mg/day ketoconazole treatment on diabetes regulation and insulin resistance in a patient with Cushing's disease reluctant to agree to surgery. This c... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012234 Tue, 12 Jul 2011 13:00:02 +0100 5012234 http://www.medworm.com/index.php?rid=5012233&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717414%26dopt%3DAbstract Authors: Rybicka M, Krysiak R, Okopień B Morning hyperglycaemia in diabetic subjects may be caused by the dawn phenomenon, or the Somogyi effect, or poor glycaemic control. The dawn phenomenon occurs when endogenous insulin secretion decreases or when the effect of the exogenous insulin administered to the patient the day before disappears, together with a physiological increase in insulin-antagonistic hormones. The Somogyi effect is present in the case of excessive amounts of exogenous insulin. The dawn phenomenon is more common than the Somogyi effect. To diagnose these phenomena, it is useful to measure plasma glucose levels for several nights between 3 a.m. and 5 a.m. or use a continuous glucose monitoring system. Although their treatment differs, the best way of preventing both t... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012233 Tue, 12 Jul 2011 13:00:02 +0100 5012233 http://www.medworm.com/index.php?rid=5012232&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717415%26dopt%3DAbstract Authors: Uzun G, Mutluoglu M, Uz O PMID: 21717415 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=5012232 Tue, 12 Jul 2011 13:00:02 +0100 5012232 http://www.medworm.com/index.php?rid=4768651&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528471%26dopt%3DAbstract Conclusions: Our study results show that both BMI Z-score and OGTT stimulated hyperinsulinaemia are good predictors of MS occurrence in obese children and adolescents. The risk of dyslipidaemia and hypertension increase significantly with hyperinsulinaemia and insulin resistance, with low HDL cholesterol being the most affected. (Pol J Endocrinol 2011; 62 (2): 102-108). PMID: 21528471 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768651 Tue, 01 Mar 2011 00:00:00 +0100 4768651 http://www.medworm.com/index.php?rid=4768650&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528472%26dopt%3DAbstract Conclusions: The significant decrease of body weight after vertical banded gastroplasty, as well as improvement of the main metabolic syndrome parameters and some adipocytokine blood levels, indicate the use of bariatric surgery as a valuable method of treating morbidly obese patients. (Pol J Endocrinol 2011; 62 (2): 109-119). PMID: 21528472 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768650 Tue, 01 Mar 2011 00:00:00 +0100 4768650 http://www.medworm.com/index.php?rid=4768649&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528473%26dopt%3DAbstract Conclusions: Women with PCOS have higher baseline and GnRH-stimulated LH concentrations. GnRH stimulation results in an increase in LH/FSH ratio in women with PCOS. Therefore we postulate that this phenomenon might be potentially useful as an additional tool in the diagnosis of PCOS. (Pol J Endocrinol 2011; 62 (2): 120-128). PMID: 21528473 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768649 Tue, 01 Mar 2011 00:00:00 +0100 4768649 http://www.medworm.com/index.php?rid=4768648&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528474%26dopt%3DAbstract Conclusions: Siblings of women with PCOS are predisposed to hormonal abnormalities typical of PCOS. The symptom of premature balding under the age of 30 in brothers of women with PCOS should not be considered as a male PCOS equivalent. (Pol J Endocrinol 2011; 62 (2): 129-133). PMID: 21528474 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768648 Tue, 01 Mar 2011 00:00:00 +0100 4768648 http://www.medworm.com/index.php?rid=4768647&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528475%26dopt%3DAbstract Conclusion: In the present case-control study, certain environmental risk factors were associated with the development of T1DM. (Pol J Endocrinol 2011; 62 (2): 134-137). PMID: 21528475 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768647 Tue, 01 Mar 2011 00:00:00 +0100 4768647 http://www.medworm.com/index.php?rid=4768646&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528476%26dopt%3DAbstract Conclusions: This study confirms the involvement of the auditory organ in type 1 diabetes mellitus. To determine the prognostic and predictive values of this finding, and methods of possible prevention of hearing loss, further prospective observations are required. (Pol J Endocrinol 2011; 62 (2): 138-144). PMID: 21528476 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768646 Tue, 01 Mar 2011 00:00:00 +0100 4768646 http://www.medworm.com/index.php?rid=4768645&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528477%26dopt%3DAbstract Conclusions: 1. It is not possible to determine unequivocally the causative factors for the growth in the incidence of thyroid cancer in Olsztyn province. 2. It appears that one of the environmental factors causing the increase is overconsumption of cruciferous vegetables. (Pol J Endocrinol 2011; 62 (2): 145-150). PMID: 21528477 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768645 Tue, 01 Mar 2011 00:00:00 +0100 4768645 http://www.medworm.com/index.php?rid=4768644&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528478%26dopt%3DAbstract Conclusions: Our results show that AngII can modulate tyrosine kinase activity in breast tumour cell lines. (Pol J Endocrinol 2011; 62 (2): 151-157). PMID: 21528478 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768644 Tue, 01 Mar 2011 00:00:00 +0100 4768644 http://www.medworm.com/index.php?rid=4768643&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528479%26dopt%3DAbstract Authors: Piekiełko-Witkowska A, Nauman A Alternative splicing of pre-mRNA is a process in which noncoding regions of primary transcript are removed and coding regions are joined in different manners to produce mRNA molecules of different sequences. Alternative splicing affects nearly all human genes and is a key source of diversity of proteins coded by a relatively small number of genes. Since alternative splicing is of crucial importance for the proper functioning of cells, including those involved in hormonal signalling, aberrations of alternative splicing can lead to disruption of cellular mechanisms and in consequence result in serious endocrine pathologies. Disturbances of alternative splicing include mutations of consensus splice regulatory sites and improprieties in the action ... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768643 Tue, 01 Mar 2011 00:00:00 +0100 4768643 http://www.medworm.com/index.php?rid=4768642&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528480%26dopt%3DAbstract Authors: Kuziemski K, Specjalski K, Jassem E Elevated levels of serum glucose have deleterious effects on the walls of blood vessels, leading to microangiopathy. Such a destructive process involves also pulmonary circulation, where it is referred to as diabetic pulmonary microangiopathy. This hypothesis has been confirmed in histopathologic examinations of pulmonary parenchyma, as well as in pulmonary function tests. However, so far there have been no clinical implications of these findings. Another phenomenon requiring further discussion involves diabetics with clinically silent respiratory dysfunction. That may result from significant vascular and ventilation reserves that compensate for partial loss of pulmonary parenchyma in the course of diabetes. In this review, we present an ove... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768642 Tue, 01 Mar 2011 00:00:00 +0100 4768642 http://www.medworm.com/index.php?rid=4768641&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528481%26dopt%3DAbstract We present the case of a 53 year-old female with Wernicke's encephalopathy caused by chronic malnutrition, surgical operation, as well as thyrotoxicosis. She received treatment with intravenous thiamine administration and also anti-thyroid treatment which caused satisfactory regression of her neurological symptoms. (Pol J Endocrinol 2011; 62 (2): 178-180). PMID: 21528481 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768641 Tue, 01 Mar 2011 00:00:00 +0100 4768641 http://www.medworm.com/index.php?rid=4768640&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528482%26dopt%3DAbstract Authors: Bednarek-Tupikowska G, Kubicka E, Sicińska-Werner T, Kazimierczak A, Winowski J, Tupikowska M, Janczyszyn M, Bolanowski M Cushing's syndrome (also known as hypercortisolemia) is rare in pregnant women due to the menstrual disturbances and infertility in women with hypercortisolism. A diagnosis of pathological hypercortisolism in pregnant women is often difficult as some symptoms of the disease may be associated with a complicated pregnancy. Hypercortisolemia leads to serious complications for mother and foetus, and is associated with premature labour and high foetal mortality. Hormonal and radiological diagnostics in pregnancy are limited. The results of hormonal measurements and dynamic tests are difficult to interpret due to the physiological changes in the hypothalamo-pitu... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768640 Tue, 01 Mar 2011 00:00:00 +0100 4768640 http://www.medworm.com/index.php?rid=4768639&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528483%26dopt%3DAbstract We present the case of a female patient with virilising adrenocortical carcinoma treated surgically who conceived during adjuvant treatment with mitotane. We discuss the frequently erroneous routine treatment with oral hormonal contraception without thorough differential diagnosis in female patients with oligo-/amenorrhea and subsequent delay in the proper diagnosis of adrenocortical carcinoma. (Pol J Endocrinol 2011; 62 (2): 186-188). PMID: 21528483 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768639 Tue, 01 Mar 2011 00:00:00 +0100 4768639 http://www.medworm.com/index.php?rid=4768638&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528484%26dopt%3DAbstract Authors: Derkacz M, Chmiel-Perzyńska I, Nowakowski A Gynecomastia is a benign, abnormal, growth of the male breast gland which can occur unilaterally or bilaterally, resulting from a proliferation of glandular, fibrous and adipose tissue. Gynecomastia is characterised by the presence of soft, 2-4 cm in diameter, usually discusshaped enlargement of tissues under the nipple. It is estimated that this pathology occurs in 32-65% of men over the age of 17. Gynecomastia is a psychosocial problem and may lead to a perceived lowering of quality of life. The main cause of gynecomastia is a loss of equilibrium between oestrogens and androgens. Increased sensitivity for oestrogens of the breast gland, or local factors (e.g. an excessive synthesis of oestrogens in breast tissues or changes in oes... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768638 Tue, 01 Mar 2011 00:00:00 +0100 4768638 http://www.medworm.com/index.php?rid=4768637&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528485%26dopt%3DAbstract Authors: Szybiński Z, Breda J In June 2010, the WHO Regional Office for Europe, in co-operation with the WHO Collaborating Centre for Nutrition at the Department of Endocrinology, Jagiellonian University, Collegium Medicum, organized in Krakow the 1(st) Conference of the WHO European Collaborating Centres for Nutrition. Taking part were representatives of the WHO Regional Office for Europe Nutrition, Dr Joao Breda (Programme Manager - Nutrition, Physical Activity and Obesity Programme) and representatives of the WHO Collaborating Centres for Nutrition from Denmark, Greece, Holland, the UK and Poland, as well as representatives of co-operating institutes from Portugal, Switzerland and the UK. The main objective of the meeting was to discuss the ongoing work of each Collaborating Centre... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768637 Tue, 01 Mar 2011 00:00:00 +0100 4768637 http://www.medworm.com/index.php?rid=4768636&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528486%26dopt%3DAbstract Authors: PMID: 21528486 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4768636 Tue, 01 Mar 2011 00:00:00 +0100 4768636 http://www.medworm.com/index.php?rid=4543401&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365571%26dopt%3DAbstract Conclusion: Fracture risk in post-stroke subjects may be increased due to disturbed skeletal and functional status. Reduction of the time interval between stroke and standing up improved wrist densitometric results. (Pol J Endocrinol 2011; 62 (1): 2-7). PMID: 21365571 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543401 Sat, 01 Jan 2011 00:00:00 +0100 4543401 http://www.medworm.com/index.php?rid=4543400&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365572%26dopt%3DAbstract Conclusions: Our study confirmed the utility of densitometric screening using forearm SXA measurements. These measurements discriminated clearly between pre- and post-menopausal subjects. Densitometric results correlated negatively with age and age at menopause, but positively with anthropometric indices related to body and skeletal size. Age was the greatest factor in terms of impact on bone loss. (Pol J Endocrinol 2011; 62 (1): 8-13). PMID: 21365572 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543400 Sat, 01 Jan 2011 00:00:00 +0100 4543400 http://www.medworm.com/index.php?rid=4543399&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365573%26dopt%3DAbstract Conclusions: A substantial proportion of persistent bisphosphonate-treated patients switch treatment from one alendronate to another. The most frequent reasons for that kind of switching are the occurrence of an adverse event and the high cost of treatment. (Pol J Endocrinol 2011; 62 (1): 14-17). PMID: 21365573 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543399 Sat, 01 Jan 2011 00:00:00 +0100 4543399 http://www.medworm.com/index.php?rid=4543398&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365574%26dopt%3DAbstract Conclusions: Prolonged concomitant treatment with high-doses of salmon calcitonin partially reverses glucocorticoid-induced depression of rat growth plate. (Pol J Endocrinol 2011; 62 (1): 18-23). PMID: 21365574 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543398 Sat, 01 Jan 2011 00:00:00 +0100 4543398 http://www.medworm.com/index.php?rid=4543397&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365575%26dopt%3DAbstract Conclusions: The obtained results indicate that better adherence to alendronate 70 therapy, administered once a week, depends on more frequent monitoring of treated patients. (Pol J Endocrinol 2011; 62 (1): 24-29). PMID: 21365575 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543397 Sat, 01 Jan 2011 00:00:00 +0100 4543397 http://www.medworm.com/index.php?rid=4543396&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365576%26dopt%3DAbstract Conclusions: 1. The FRAX calculator does not always consider the history of low-energy fractures as a criterion sufficient for therapy implementation. 2. Designing a FRAX calculator specifically for the Polish population would be advisable. (Pol J Endocrinol 2011; 62 (1): 30-36). PMID: 21365576 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543396 Sat, 01 Jan 2011 00:00:00 +0100 4543396 http://www.medworm.com/index.php?rid=4543395&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365577%26dopt%3DAbstract Authors: Sewerynek E Steroid-induced osteoporosis is a textbook example of the secondary type of this medical condition. Glucocorticosteroids suppress bone formation by their direct and indirect effect on osteoblasts, osteoclasts and osteocytes, increasing their resorption and, eventually, leading to negative bone balance. A clinical problem arises regarding the fact that approximately 50% of patients on chronic steroid therapy undergo asymptomatic bone fractures. The treatment mode includes minimising the dose of administered steroids, encouraging an improved lifestyle and supplementation with adequate calcium and vitamin D3 doses. Bisphosphonates are a group of medical agents used both to prevent and treat steroid-induced osteoporosis, although new therapies have also become availabl... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543395 Sat, 01 Jan 2011 00:00:00 +0100 4543395 http://www.medworm.com/index.php?rid=4543394&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365578%26dopt%3DAbstract Authors: Horst-Sikorska W, Ignaszak-Szczepaniak M Anorexia nervosa (AN) has in recent years become considerably more common. The disease primarily affects girls and young women, and also boys and young men. AN is a risk factor for secondary osteoporosis. AN-related metabolic disturbances lead to diminished bone quality and increased risk of fractures. The consequences of low energy fractures are the main causes of death in women with AN. Hormonal disturbances (e.g. hypoestrogenism, increased levels of ghrelin and Y peptide, changes in leptin and endocannabinoid levels), as well as the mechanisms involved in bone resorption (RANK/RANKL/OPG), are considered to be of great importance for anorectic bone quality. The risk of osteoporotic, non-vertebral fractures in AN patients is significan... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543394 Sat, 01 Jan 2011 00:00:00 +0100 4543394 http://www.medworm.com/index.php?rid=4543393&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365579%26dopt%3DAbstract Authors: Pluskiewicz W Loss of bone mineral density and fractures in patients after stroke are among the most serious health complications. Regarding serious post-stroke impediments, significantly contributing to elevated fracture incidence are falls. An increasing number of subjects after stroke have been observed and better understanding of the nature of skeletal changes might improve the efficacy of their management. The most important issues in post-stroke patients include an evaluation of bone loss magnitude, the occurrence of falls, fracture incidence and prevention procedures. An early start of pharmacological treatment plus exercise are recommended procedures in the early post-stroke stages, in order to diminish as much as possible subsequent bone loss, the direct consequences ... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543393 Sat, 01 Jan 2011 00:00:00 +0100 4543393 http://www.medworm.com/index.php?rid=4543392&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365580%26dopt%3DAbstract Authors: Sewerynek E, Stuss M Osteoporosis is a chronic disease of the osseous system characterised by decreased strength of bone tissue, which in turn leads to increased fracture risk. It has been demonstrated that osteoporosis affects more than 30% of women after the menopause (WHO, 1994). However, the disease is also observed in men. The primary goals of osteoporosis therapy include prevention of low-energy fractures and general improvement of quality of life. Any patient with diagnosed osteoporosis requires, besides prevention, the application of proper treatment. Of the available therapeutic options, the best are bisphosphonates, medical agents with well identified properties, therapeutic efficacy, and safety which has been confirmed in many clinical studies. Therefore, they are r... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543392 Sat, 01 Jan 2011 00:00:00 +0100 4543392 http://www.medworm.com/index.php?rid=4543391&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365581%26dopt%3DAbstract Authors: Horst-Sikorska W, Wawrzyniak A In developed societies, the post-menopausal period covers approximately one third of a woman's life. The deficit of oestrogens observed during the post-menopausal period significantly affects the course of many metabolic processes, causing a number of diseases and in consequence diminishing quality of life. Among others, bones belong to oestrogen-dependent tissues. The deficit of the protective influence of oestrogens compromises the dynamic balance of the bone transformation process towards resorption, thus reducing bone mass and quality, while increasing the risk of low-energy fractures. In recent years, differing views on the application of oestrogen/gestagen therapy have reached the level of controversy. The results of numerous clinical studi... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543391 Sat, 01 Jan 2011 00:00:00 +0100 4543391 http://www.medworm.com/index.php?rid=4543390&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365582%26dopt%3DAbstract Authors: Przedlacki J Strontium ranelate is one of the first-line agents with proven anti-fracture activity used in the therapy of post-menopausal osteoporosis. Its mechanism of action makes it, however, different from other drugs, since it simultaneously stimulates two reverse processes: bone formation and bone resorption. The action of the agent depends on various mechanisms, including the activation of calcium receptors, localised on osteoblasts and osteoclasts, and on the influence on the OPG/RANKL system. The drug effectively prevents spinal, hip and extravertebral fractures. The agent's anti-fracture efficacy within the spine does not depend on the patient's age, or on base BMD values, or on the concentration of bone metabolism markers. As to the anti-fracture efficacy in the hip... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543390 Sat, 01 Jan 2011 00:00:00 +0100 4543390 http://www.medworm.com/index.php?rid=4543389&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365583%26dopt%3DAbstract Authors: Misiorowski W Most medical agents currently applied in osteoporosis therapy act by inhibiting bone resorption and reducing bone remodelling, i.e. they inhibit the process of bone mass loss by suppressing bone resorption processes. These drugs provide an ideal therapeutic option to prevent osteoporosis progression. They however have a rather limited usefulness when the disease has already reached its advanced stages with distinctive bone architecture lesions. The fracture risk reduction rate, achieved in the course of anti-resorptive therapy, is insufficient for patients with severe osteoporosis to stop the downward spiral of their quality of life (QoL) with a simultaneously increasing threat of premature death. The activity of the N-terminal fragment of 1-34 human parathormone... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543389 Sat, 01 Jan 2011 00:00:00 +0100 4543389 http://www.medworm.com/index.php?rid=4543388&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365584%26dopt%3DAbstract Authors: Franek E Denosumab is the international name of a human, monoclonal antibody approved for the treatment of osteoporosis. This antibody is associated with RANK ligand (RANKL), inactivating it. In consequence, the formation and survival of osteoclasts are suppressed, leading to their apoptosis. All this results in lower bone resorption, while bone mineral density (BMD) increases. Denosumab also reduces the risk of vertebral and non-vertebral fractures. This agent is similarly effective in various stages of renal function impairment; it does not impair fracture healing processes nor contribute to atherosclerosis progression in patients with high cardiovascular risks. Following an analysis of adverse effects, performed in the FREEDOM study (in which it was demonstrated that the in... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543388 Sat, 01 Jan 2011 00:00:00 +0100 4543388 http://www.medworm.com/index.php?rid=4543387&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365585%26dopt%3DAbstract Authors: Czerwiński E There have been many reports published in recent years on atypical subtrochanteric fractures after long-term bisphosphonates therapy. In a description of a few series of cases, fractures of typical clinical course and radiological image have been documented. These fractures are estimated as very rare (2.3 per 10,000 patient-years). It is suggested that a subsequent use of steroids or proton pump inhibitors with bisphosphonates may increase the risk of fracture occurrence. (Pol J Endocrinol 2011; 62 (1): 84-87). PMID: 21365585 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543387 Sat, 01 Jan 2011 00:00:00 +0100 4543387 http://www.medworm.com/index.php?rid=4543386&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365586%26dopt%3DAbstract Authors: Drozdzowska B This review looks at osteonecrosis in the stomatognathic system (mainly the jaws). Osteonecrosis of the jaw (ONJ) is a rare but serious clinical condition. It affects patients treated with bisphosphonates, and also with denosumab, mainly in oncological doses. In osteoporosis, it is a problem of relatively small significance. Article presents a thorough review of this phenomenon, including its definition, pathogenesis, risk factors, prevention and treatment methods, and its incidence rate. (Pol J Endocrinol 2011; 62 (1): 88-92). PMID: 21365586 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543386 Sat, 01 Jan 2011 00:00:00 +0100 4543386 http://www.medworm.com/index.php?rid=4543385&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365587%26dopt%3DAbstract Authors: Sewerynek E, Stuss M Osteoporosis is a growing problem in an ageing society. It affects women of post-menopausal age, as well as elderly subjects of both sexes, often with dysfunction of the cardiovascular system or with an increased risk of circulation disorders. It has been found that the mortality rate of subjects with osteoporosis is comparable to that of patients suffering from such diseases as obturative pulmonary disease or myocardial ischaemia. Bisphosphonates are the most thoroughly studied group of drugs prescribed for the treatment of osteoporosis. Their administration is, however, associated with a risk of adverse symptoms, which can occur as gastro-intestinal tract disturbances, muscular-osseous pains, mandible necrosis, atypical fractures and other symptoms. Rece... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543385 Sat, 01 Jan 2011 00:00:00 +0100 4543385 http://www.medworm.com/index.php?rid=4543384&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21365588%26dopt%3DAbstract Authors: PMID: 21365588 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4543384 Sat, 01 Jan 2011 00:00:00 +0100 4543384 http://www.medworm.com/index.php?rid=4140736&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049469%26dopt%3DAbstract Authors: Jarząb B, Sporny S, Lange D, Włoch J, Lewiński A PMID: 21049469 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140736 Sun, 07 Nov 2010 22:20:07 +0100 4140736 http://www.medworm.com/index.php?rid=4140735&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049470%26dopt%3DAbstract Authors: Jarząb B, Słowińska-Klencka D PMID: 21049470 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140735 Sun, 07 Nov 2010 22:20:07 +0100 4140735 http://www.medworm.com/index.php?rid=4140754&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049451%26dopt%3DAbstract Conclusions: Our preliminary results do support the use of MIBI-Tc99m in the evaluation of indeterminate thyroid nodules. To validate the hypothesis that MIBI-Tc(99m) may be used to exclude malignancy in lesions indeterminate by FNAB we propose to use SPECT-CT derived images and standardized evaluation criteria. (Pol J Endocrinol 2010; 61 (5): 422-426). PMID: 21049451 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140754 Wed, 01 Sep 2010 00:00:00 +0100 4140754 http://www.medworm.com/index.php?rid=4140753&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049452%26dopt%3DAbstract Conclusions: Follicular tumour diagnosed by fine needle aspiration biopsy in patients after treatment for other cancers, especially renal clear cell carcinoma, should alert the surgeon to the possibility that it could be a metastasis of this cancer to the thyroid gland. (Pol J Endocrinol 2010; 61 (5): 427-429). PMID: 21049452 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140753 Wed, 01 Sep 2010 00:00:00 +0100 4140753 http://www.medworm.com/index.php?rid=4140752&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049453%26dopt%3DAbstract Conclusions: Procalcitonin has a similar distribution of values as calcitonin and may be used for evaluation of MTC status in some situations when accurate CT estimation is not achievable. (Pol J Endocrinol 2010; 61 (5): 430-436). PMID: 21049453 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140752 Wed, 01 Sep 2010 00:00:00 +0100 4140752 http://www.medworm.com/index.php?rid=4140751&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049454%26dopt%3DAbstract Conclusions: 1. It cannot be stated that the Chernobyl disaster had any influence on the incidence rate of thyroid carcinoma in the province of Olsztyn. 2. Iodine prophylaxis using Lugol's solution could have an influence on lack of significant increase of the thyroid carcinoma incidence rate in the age group 1-18 years. (Pol J Endocrinol 2010; 61 (5): 437-442). PMID: 21049454 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140751 Wed, 01 Sep 2010 00:00:00 +0100 4140751 http://www.medworm.com/index.php?rid=4140750&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049455%26dopt%3DAbstract Conclusions: 1. The highest percentage of complete remission was observed in patients with lymph nodes but without distant metastases (group I). 2. In the case of the presence of distant metastases there was no statistically significant difference in the percentage of complete remission between patients with or without the presence of metastases in lymph nodes. (Pol J Endocrinol 2010; 61 (5): 443-445). PMID: 21049455 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140750 Wed, 01 Sep 2010 00:00:00 +0100 4140750 http://www.medworm.com/index.php?rid=4140749&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049456%26dopt%3DAbstract Conclusions: Focal lesions near the hyoid bone, revealed in patients operated previously for benign goitre, are not related to increased risk of thyroid neoplasm, and their enlargement does not imply their malignancy. (Pol J Endocrinol 2010; 61 (5): 448-453). PMID: 21049456 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140749 Wed, 01 Sep 2010 00:00:00 +0100 4140749 http://www.medworm.com/index.php?rid=4140748&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049457%26dopt%3DAbstract Conclusions: Malignant thyroid lesions in patients after RT due to benign thyroid diseases are seldom detected. However, periodical clinical and ultrasonographic evaluation is recommended. (Pol J Endocrinol 2010; 61 (5): 454-457). PMID: 21049457 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140748 Wed, 01 Sep 2010 00:00:00 +0100 4140748 http://www.medworm.com/index.php?rid=4140747&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049458%26dopt%3DAbstract Conclusions: Urinary iodine concentrations in differentiated thyroid cancer patients treated with L-thyroxine vary in a wide range and do not show a clear relation with L-thyroxine dose. (Pol J Endocrinol 2010; 61 (5): 458-461). PMID: 21049458 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140747 Wed, 01 Sep 2010 00:00:00 +0100 4140747 http://www.medworm.com/index.php?rid=4140746&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049459%26dopt%3DAbstract Conclusions: Although many studies document BRAF mutation as a prognostic factor in PTC our results underline that it is too early to consider it as a routine clinical predictive factor. (Pol J Endocrinol 2010; 61 (5): 462-466). PMID: 21049459 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140746 Wed, 01 Sep 2010 00:00:00 +0100 4140746 http://www.medworm.com/index.php?rid=4140745&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049460%26dopt%3DAbstract Conclusions: Poorly differentiated thyroid carcinoma is still a challenge both for pathologists and clinicians. Infrequent prevalence, more aggressive course, and poorer prognosis constitute major problems for the clinicians. (Pol J Endocrinol 2010; 61 (5): 467-473). PMID: 21049460 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140745 Wed, 01 Sep 2010 00:00:00 +0100 4140745 http://www.medworm.com/index.php?rid=4140744&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049461%26dopt%3DAbstract Conclusions: rhTSH may be safely used for (131)I thyroid remnant ablation in low-risk DTC patients. (Pol J Endocrinol 2010; 61 (5): 474-479). PMID: 21049461 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140744 Wed, 01 Sep 2010 00:00:00 +0100 4140744 http://www.medworm.com/index.php?rid=4140743&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049462%26dopt%3DAbstract Conclusions: 1. In 2008 the contribution of papillary histotype to all thyroid cancer patients (87%) was significantly higher than in 1999. 2. The percentage of DTC patients diagnosed with pT1 disease was significantly higher in 2008. (Pol J Endocrinol 2010; 61 (5): 480-484). PMID: 21049462 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140743 Wed, 01 Sep 2010 00:00:00 +0100 4140743 http://www.medworm.com/index.php?rid=4140742&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049463%26dopt%3DAbstract Authors: Kula D, Kalemba M, Jurecka-Lubieniecka B, Puch Z, Kowalska M, Tyszkiewicz T, Kowal M, Handkiewicz-Junak D Approximately 5% of differentiated thyroid cancers are hereditary. Hereditary non-medullary thyroid cancer may occur as a minor component of familial cancer syndromes (e.g. familial adenomatous polyposis) or as a primary feature (familial non-medullary thyroid cancer [FNMTC]). Among FNMTC, PTC is the most common. Although a hereditary predisposition to non-medullary thyroid cancer is well established, the susceptibility genes are poorly known. Up to now, by linkage analysis using microsatellite markers, several putative loci have been described - 1q21, 6q22, 8p23.1-p22, and 8q24; however, validation studies have been unsuccessful. In the present review we discuss the resul... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140742 Wed, 01 Sep 2010 00:00:00 +0100 4140742 http://www.medworm.com/index.php?rid=4140741&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049464%26dopt%3DAbstract We present this case to document no adverse effects of therapy with sorafenib in a patient with brain DTC metastases. Sorafenib therapy was only short-term, but no progression occurred in this time. (Pol J Endocrinol 2010; 61 (5): 492-496). PMID: 21049464 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140741 Wed, 01 Sep 2010 00:00:00 +0100 4140741 http://www.medworm.com/index.php?rid=4140740&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049465%26dopt%3DAbstract Conclusions: Disseminated thyroid cancer in a patient with pituitary insufficiency may be successfully treated by rhTSH-supported (131)I treatment. (Pol J Endocrinol 2010; 61 (5): 497-501). PMID: 21049465 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140740 Wed, 01 Sep 2010 00:00:00 +0100 4140740 http://www.medworm.com/index.php?rid=4140739&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049466%26dopt%3DAbstract Authors: Lizis-Kolus K, Kowalska A, Kozak-Klonowska B, Siołek M, Słuszniak J, Lubiński J, Cybulski C The CHEK2 gene encodes the CHK2 protein, which is kinase involved in DNA repair processes. By activating a lot of cell substrates, it can regulate the cell cycle, demonstrates suppressive effects, and participates in the senescence and apoptosis processes. Mutations in the CHEK2 gene are associated with increased risk of numerous cancers. The case described herein is that of a woman with a missense mutation that results in the substitution of isoleucine for threonine at position 157. This variant of the mutation doubles the risk of papillary thyroid carcinoma two times and causes up to 9% of these cancer. It is also associated with a two-fold increased risk of cancers of the kidney (... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140739 Wed, 01 Sep 2010 00:00:00 +0100 4140739 http://www.medworm.com/index.php?rid=4140738&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049467%26dopt%3DAbstract Conclusions: On the basis of the presented cases we conclude that PET-CT scan with somatostatin analogue labelled with gallium ((68)Ga-DOTA-TATE PET-CT) may be useful in the diagnostic imaging of patients with disseminated MTC. (Pol J Endocrinol 2010; 61 (5): 507-511). PMID: 21049467 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140738 Wed, 01 Sep 2010 00:00:00 +0100 4140738 http://www.medworm.com/index.php?rid=4140737&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049468%26dopt%3DAbstract Conclusions: 1. Fine needle aspiration biopsy of the thyroid gland should obligatorily be performed in patients with breast cancer and nodular goitre, even without any clinical data of metastatic disease. 2. The clinical context of cytological findings is of critical value. 3. In patients with breast cancer accompanied by multinodular goitre, we recommend that more punctures be performed during FNAB than is routinely done. (Pol J Endocrinol 2010; 61 (5): 512-515). PMID: 21049468 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140737 Wed, 01 Sep 2010 00:00:00 +0100 4140737 http://www.medworm.com/index.php?rid=4140734&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21049471%26dopt%3DAbstract IV Conference "Thyroid cancer" Zakopane, 20-22 May 2010. Endokrynol Pol. 2010 Sep-Oct;61(5):576-644 Authors: PMID: 21049471 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=4140734 Wed, 01 Sep 2010 00:00:00 +0100 4140734 http://www.medworm.com/index.php?rid=3727346&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602299%26dopt%3DAbstract Conclusions: In patients with acromegaly, the incidence rate of type 2 diabetes is 3-4-times higher than in the rest of the population and increases with age, especially after the age of 60. (Pol J Endocrinol 2010; 61 (3): 260-263). PMID: 20602299 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727346 Tue, 06 Jul 2010 22:00:04 +0100 3727346 http://www.medworm.com/index.php?rid=3727345&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602300%26dopt%3DAbstract Conclusions: 1. Surgical treatment of secondary or tertiary hyperparathyroidism requires close cooperation between the surgeon, nephrologist, internist, and anaesthesiologist. 2. Successful results of the treatment, including minimum cardiovascular complications, can only be obtained in integrated cooperation with a dialysis centre (Pol J Endocrinol 2010; 61 (3): 264-268). PMID: 20602300 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727345 Tue, 06 Jul 2010 22:00:04 +0100 3727345 http://www.medworm.com/index.php?rid=3727344&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602301%26dopt%3DAbstract Conclusions: GLUT4 overexpression in subjects with positive family history of type 2 diabetes mellitus suggests that cellular glucose transport disturbances occur prior to hyperglycaemia. Determination of GLUT4 expression appears to be a possibly useful method of early detection in individuals at high risk of diabetes. (Pol J Endocrinol 2010; 61 (3): 269-274). PMID: 20602301 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727344 Tue, 06 Jul 2010 22:00:04 +0100 3727344 http://www.medworm.com/index.php?rid=3727343&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602302%26dopt%3DAbstract Conclusions: HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT. (Pol J Endocrinol 2010; 61 (3): 275-279). PMID: 20602302 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727343 Tue, 06 Jul 2010 22:00:04 +0100 3727343 http://www.medworm.com/index.php?rid=3727342&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602303%26dopt%3DAbstract Conclusions: Our results indicate that perindopril is superior to enalapril when it comes to affecting the hormonal function of human adipose tissue. This suggests that tissue-type angiotensin-converting enzyme inhibitors are a better treatment option for normotensive individuals with CAD than plasma-type ones. (Pol J Endocrinol 2010; 61 (3): 280-286). PMID: 20602303 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727342 Tue, 06 Jul 2010 22:00:04 +0100 3727342 http://www.medworm.com/index.php?rid=3727341&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602304%26dopt%3DAbstract Conclusions: The prevalence of goiter is still high in Isfahan schoolchildren. It seems that zinc status is not involved in the high prevalence of goiter in this region. The role of other possible goitrogens should be investigated in Isfahan. (Pol J Endocrinol 2010; 61 (3): 287-290). PMID: 20602304 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727341 Tue, 06 Jul 2010 22:00:04 +0100 3727341 http://www.medworm.com/index.php?rid=3727340&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602305%26dopt%3DAbstract Authors: Czech A, Tatoń J, Piątkiewicz P The current world epidemic of type 2 diabetes mellitus results from two general groups of causative factors. One is the influence of strong pathogenetic environmental pressures - also described as negative civilizational influence - on the very large subpopulation, assessed at 30% of the total world population, which is genetically predisposed to react to this external stress with the symptoms of type 2 diabetes mellitus. Such a pathogenetic reaction is based on the appearance of cellular and organ resistance to insulin. A second factor involves the beta cells of the pancreatic islets and their dysfunction. For these reasons, studies on the aetiology of insulin resistance have significance, both theoretical and practical. There are many bi... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727340 Tue, 06 Jul 2010 22:00:04 +0100 3727340 http://www.medworm.com/index.php?rid=3727339&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602306%26dopt%3DAbstract Authors: Tatoń J, Piątkiewicz P, Czech A The normalization of cellular glucose assimilation is the basic aim of metabolic therapy in type 2 diabetes mellitus (T2DM). It requires parallel changes in the process of cellular glucose transport (CGT). This review presents the pathophysiological and clinical outlines of CGT. Sequentially, the advances in the mechanisms and classification of CGT and their physiological and molecular base are described. The role of CGT pathogenetic significance in diabetes mellitus is stressed. Finally, the opinion is expressed that the CGT study is a potentially important approach to clinical interpretation of glucose metabolism disturbances and their pharmacotherapy. (Pol J Endocrinol 2010; 61 (3): 303-310). PMID: 20602306 [PubMed - as supplied by ... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727339 Tue, 06 Jul 2010 22:00:04 +0100 3727339 http://www.medworm.com/index.php?rid=3727338&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602307%26dopt%3DAbstract Authors: Witek P, Zgliczyński W, Zieliński G, Jeske W Cushing's disease is related to a significant increase in mortality due to chronic hypercortisolaemia complications. It is known that 50% of non-treated subjects die within 5 years. Transsphenoidal selective adenomectomy is the treatment of choice. The incidence of relapses, even following a successful surgical procedure, is high and reaches 20-25% during the 5-year follow-up period. The authors discuss the case of a patient, currently aged 60, after repeat pituitary surgery, with progressive cardiovascular complications, in whom persistent Cushing's disease was diagnosed. The diagnosis was determined despite normal plasma ACTH, serum cortisol levels, and 17-OHCS concentrations in daily urine. There was also a lack of obvious ... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727338 Tue, 06 Jul 2010 22:00:04 +0100 3727338 http://www.medworm.com/index.php?rid=3727337&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602308%26dopt%3DAbstract We report an 8-year-old proband with severe motor and intellectual disability presenting a variety of dysmorphic features such as microcephaly, prominent glabella (ridged metopic suture) and congenital distal limb contractures. As well as panhypopituitary insufficiency, brain defects, e.g. agenesis of corpus callosum, colpocephaly, and pachygyria as well as strabismus and tracheo-laryngeal hypoplasia, were diagnosed. Genetic examination revealed a normal karyotype and excluded Wolf-Hirschhorn syndrome and subtelomeric deletions. Chitayat-Hall syndrome was diagnosed based on clinical traits. (Pol J Endocrinol 2010; 61 (3): 318-321). PMID: 20602308 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727337 Tue, 06 Jul 2010 22:00:04 +0100 3727337 http://www.medworm.com/index.php?rid=3727336&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602309%26dopt%3DAbstract Authors: Hubalewska-Dydejczyk A, Trofimiuk M, Sowa-Staszczak A, Gilis-Januszewska A, Baczyńska E, Szybiński P, Anielski R, Matłok M, Bonicki W, Kunikowska J Neuroendocrine tumours (NETs) arising from dispersed endocrine system may originate from almost every location, although they are most commonly found in the gastrointestinal tract and respiratory system. NETs are considered as particularly rare if they constitute less than 1% of all neuroendocrine tumours. The aim of the paper is to present ten rare NETs from the database of the Endocrinology Department of the Jagiellonian University, Medical College: 4 NETs of the ampulla of Vater, 2 of the gallbladder, and 1 of the ovary, sphenoid sinus, Meckel's diverticulum, and epiglottis. The clinical presentation of such tumours and... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727336 Tue, 06 Jul 2010 22:00:04 +0100 3727336 http://www.medworm.com/index.php?rid=3727335&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20602310%26dopt%3DAbstract Authors: Ruchała M, Szczepanek E The introduction of sonographic imaging has revolutionized the diagnostics of thyroid pathologies. Nowadays, thyroid ultrasound examination has become an essential part of routine thyroid gland evaluation. Although one of the greatest advantages of this examination lies in its simplicity, it requires a solid theoretical background, as well as a lot of experience for the examiner to become fluent in adequate interpretation of its results. The aim of this summary is to present a review of the most important aspects of both the technique and interpretation of thyroid ultrasound pictures with regard to the most common difficulties a thyroid sonographer may come across in everyday practice. (Pol J Endocrinol 2010; 61 (3): 330-344). PMID: 20602310 [Pub... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3727335 Tue, 06 Jul 2010 22:00:04 +0100 3727335 http://www.medworm.com/index.php?rid=3567074&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464701%26dopt%3DAbstract Conclusions: The results of this study may suggest the beneficial impact of a low-calorie diet on the slowing down of inflammatory processes. The observed negative correlation between the concentrations of adiponectin and inflammatory cytokines may confirm the anti-inflammatory activity of this adipokine. (Pol J Endocrinol 2010; 61 (2): 160-168). PMID: 20464701 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567074 Mon, 01 Mar 2010 00:00:00 +0100 3567074 http://www.medworm.com/index.php?rid=3567073&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464702%26dopt%3DAbstract Conclusions: We found elevated levels of visfatin in obese subjects, which did not correlate with the majority of anthropometric parameters with the exception of WHR (negative correlation). This correlation may suggest that elevated visfatin levels are associated with the distribution of adipose tissue characteristic of gynoid rather than visceral obesity. In the group of obese subjects, visfatin levels decreased with age and glycated haemoglobin levels. (Pol J Endocrinol 2010; 61 (2): 169-173). PMID: 20464702 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567073 Mon, 01 Mar 2010 00:00:00 +0100 3567073 http://www.medworm.com/index.php?rid=3567072&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464703%26dopt%3DAbstract Conclusions: Depression in obese women does not seem to be related to the plasma levels of ghrelin and PYY. (Pol J Endocrinol 2010; 61 (2): 174-177). PMID: 20464703 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567072 Mon, 01 Mar 2010 00:00:00 +0100 3567072 http://www.medworm.com/index.php?rid=3567071&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464704%26dopt%3DAbstract Conclusions: It seems that cytoplasmic localization of SSTR5, SSTR2A, and SSTR2B is connected with enhanced GH inhibition after octreotide administration. It is possible that this somatostatin analogue alters the localization of subtypes SSTR2A and SSTR2B through the receptor internalization. As a consequence, the SSTR-immunopositivity in cell cytoplasm is increased. The cytoplasmic but not the membranous localization is connected with the higher responsiveness to the octreotide in somatotropinomas. (Pol J Endocrinol 2010; 61 (2): 178-181). PMID: 20464704 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567071 Mon, 01 Mar 2010 00:00:00 +0100 3567071 http://www.medworm.com/index.php?rid=3567070&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464705%26dopt%3DAbstract Conclusions: Peripheral blood lymphocytes may become an interesting model system to study the effects of insulin on cellular glucose transport. Flow cytometry is suitable for this investigation and may be used as a method to estimate the influence of insulin on GLUTprotein translocation and the dynamics of glucose uptake by lymphocytes. (Pol J Endocrinol 2010; 61 (2): 182-187). PMID: 20464705 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567070 Mon, 01 Mar 2010 00:00:00 +0100 3567070 http://www.medworm.com/index.php?rid=3567069&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464706%26dopt%3DAbstract Conclusions: The prevalence of thyroid nodule by sonography is still high despite relatively normal urinary iodine in this population. (Pol J Endocrinol 2010; 61 (2): 188-191). PMID: 20464706 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567069 Mon, 01 Mar 2010 00:00:00 +0100 3567069 http://www.medworm.com/index.php?rid=3567068&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464707%26dopt%3DAbstract Authors: Boguszewski CL, Paz-Filho G, Velloso LA Human body weight is maintained at a fairly stable level regardless of changes in energy intake and energy expenditure. Compensatory mechanisms within the central nervous system (CNS), which regulate food intake and energy expenditure, are triggered by other central and peripheral signals. Peripherally, the main sources of those signals are the adipose tissue, gastrointestinal tract, and pancreas. The main signal originating from the adipose tissue is leptin, which promotes the activation of anorexigenic pathways in the CNS. Similarly, the central action of insulin also reduces food intake and stimulates catabolic pathways. The gastrointestinal tract contributes with several peptides that influence food intake, such as ghrelin, glucagon-... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567068 Mon, 01 Mar 2010 00:00:00 +0100 3567068 http://www.medworm.com/index.php?rid=3567067&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464708%26dopt%3DAbstract Authors: Lenarcik A, Bidzińska-Speichert B Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorder in premenopausal women and is frequently accompanied by the presence of cardiovascular risk factors. It has also been recognized that PCOS women are characterized by cardiopulmonary impairment. Reduced cardiopulmonary functional capacity and the autonomic dysfunction associated with abnormal heart rate recovery might be responsible for the increased cardiovascular risk in patients with PCOS. Exercise training has beneficial effects on cardiopulmonary functional capacity and reduces the risk of cardiovascular disease in PCOS women. (Pol J Endocrinol 2010; 61 (2): 207-209). PMID: 20464708 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567067 Mon, 01 Mar 2010 00:00:00 +0100 3567067 http://www.medworm.com/index.php?rid=3567066&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464709%26dopt%3DAbstract Conclusions: Careful screening for MEN 1 is important in young patients with pituitary tumours. Regular follow up is crucial even after surgical treatment. The presented patient developed gradual enlargement of insulinomas and reoccurrence of hyperparathyroidism as well. (Pol J Endocrinol 2010; 61 (2): 212-216). PMID: 20464709 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567066 Mon, 01 Mar 2010 00:00:00 +0100 3567066 http://www.medworm.com/index.php?rid=3567065&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464710%26dopt%3DAbstract Authors: Skałba P, Cygal A, Gierzyńska Z A case of POF in a 31-year-old woman with karyotype 47,XXX. The aim of the study was to discuss a case of POF in a 31-year-old patient with polysomy 47,XXX. The described karyotype is not usually associated with this characteristic physical phenotype. In some rare cases, menstrual disorders, sterility, secondary amenorrhoea, premature menopause, and low intelligence are found. Our observations revealed the necessity for cytogenetic examination in all women at reproductive age with symptoms of premature ovarian failure. According to the data found in literature, patients with POF and karyotype disorders belong to the risk group of premature death, mostly for cardiological reasons. Raising patient awareness about the risk may have a positive... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567065 Mon, 01 Mar 2010 00:00:00 +0100 3567065 http://www.medworm.com/index.php?rid=3567064&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464711%26dopt%3DAbstract Authors: Wall JR, Lahooti H Thyroid associated ophthalmopathy, or thyroid eye disease (TED), is a complex inflammatory disorder of the eye that, as its name implies, is usually associated with thyroid disease. Clinical observation supports the existence of three main TED subtypes, namely ocular myopathy, congestive myopathy, and mixed congestive and myopathic ophthalmopathy. Although the precise pathophysiology of TED remains unclear, it is likely to reflect an autoimmune reaction involving sensitised T lymphocytes and autoantibodies directed against a specific orbital or thyroid-and-orbital shared antigen(s). One well-studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSHR), which is also expressed in the orbital fibroblast and preadipocyte. Most pa... Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567064 Mon, 01 Mar 2010 00:00:00 +0100 3567064 http://www.medworm.com/index.php?rid=3567063&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464712%26dopt%3DAbstract Authors: Adequate vitamin D intake and its status are important not only for bone health and Ca-P metabolism, but for optimal function of many organs and tissues throughout the body. Due to documented changes in dietary habits and physical activity levels, both observed in growing children and adults, the prevalence of vitamin D insufficiency is continuously increasing. National consultants and experts in the field have established some Polish recommendations for prophylactic vitamin D supplementation in infants, toddlers, children, and adolescents as well as in adults, including pregnant and lactating women basing on a review of current literature. (Pol J Endocrinol 2010; 61 (2): 228-232). PMID: 20464712 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567063 Mon, 01 Mar 2010 00:00:00 +0100 3567063 http://www.medworm.com/index.php?rid=3567062&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464713%26dopt%3DAbstract 4(th) Poland-wide Scientific Conference "Progress in diagnosis and treatment of neuroendocrine tumors". Wisła - Hotel Stok, 16 April 2010 Program. Endokrynol Pol. 2010 Mar-Apr;61(2):234-8 Authors: PMID: 20464713 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567062 Mon, 01 Mar 2010 00:00:00 +0100 3567062 http://www.medworm.com/index.php?rid=3567061&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20464714%26dopt%3DAbstract Authors: PMID: 20464714 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3567061 Mon, 01 Mar 2010 00:00:00 +0100 3567061 http://www.medworm.com/index.php?rid=3338771&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205097%26dopt%3DAbstract Conclusions: The most common indication for primary screening was the presence of incidentally found adrenal mass. The quotient of plasma aldosterone concentration/plasma renin activity at whichever cut-off point is not effective enough for the selection of patients for further diagnostics or its cessation. (Pol J Endocrinol 2010; 61 (1): 2-5). PMID: 20205097 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338771 Fri, 01 Jan 2010 00:00:00 +0100 3338771 http://www.medworm.com/index.php?rid=3338770&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205098%26dopt%3DAbstract Conclusions: The study indicates that endogenous TSH stimulation plays a role in the regulation of endostatin secretion. Although median serum endostatin levels are higher in patients with distant metastases than in patients with remission, its clinical usefulness is limited due to the overlapping data between the study groups. (Pol J Endocrinol 2010; 61 (1): 7-12). PMID: 20205098 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338770 Fri, 01 Jan 2010 00:00:00 +0100 3338770 http://www.medworm.com/index.php?rid=3338769&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205099%26dopt%3DAbstract Conclusion: It can be concluded that one year of LT(4) treatment of adolescent girls with euthyroid diffuse goiter does not have a negative impact on their bone remodelling and metabolism. (Pol J Endocrinol 2010; 61 (1): 14-19). PMID: 20205099 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338769 Fri, 01 Jan 2010 00:00:00 +0100 3338769 http://www.medworm.com/index.php?rid=3338768&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205100%26dopt%3DAbstract Conclusions: 1. Our data do not support the major role of ghrelin in blood pressure regulation in obesity. 2. An increase of plasma ghrelin concentration after treatment with cilazapril was observed. (Pol J Endocrinol 2010; 61 (1): 21-27). PMID: 20205100 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338768 Fri, 01 Jan 2010 00:00:00 +0100 3338768 http://www.medworm.com/index.php?rid=3338767&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205101%26dopt%3DAbstract Conclusions: From our retrospective study, we suggest an overall increase of tumour incidence in acromegalic patients. Prospective multicentre studies are required to resolve the significance of this observation. In our study group, the number of malignant neoplasms was significantly higher in patients with long-lasting uncontrolled disease (over 5 years), compared to patients with controlled disease. (Pol J Endocrinol 2010; 61 (1): 29-34). PMID: 20205101 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338767 Fri, 01 Jan 2010 00:00:00 +0100 3338767 http://www.medworm.com/index.php?rid=3338766&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205102%26dopt%3DAbstract Conclusions: A decreased concentration of adiponectin in obese people is an early predictor of metabolic syndrome. A low adiponectin level could be a marker of high risk of cardiovascular disease in obese patients. (Pol J Endocrinol 2010; 61 (1): 36-41). PMID: 20205102 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338766 Fri, 01 Jan 2010 00:00:00 +0100 3338766 http://www.medworm.com/index.php?rid=3338765&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205103%26dopt%3DAbstract Conclusions: The results of our study show that genetic predisposition is frequent in chromaffin tissue tumours, which indicates that DNA analysis is necessary in every case, also because of possible atypical clinical presentation. (Pol J Endocrinol 2010; 61 (1): 43-48). PMID: 20205103 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338765 Fri, 01 Jan 2010 00:00:00 +0100 3338765 http://www.medworm.com/index.php?rid=3338764&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205104%26dopt%3DAbstract Conclusions: On the basis of the conducted studies it can be concluded that the greater FGF-21 concentration observed in the examined group of patients with type 2 diabetes may result from a compensatory reaction to metabolic disturbances or tissue resistance to this cytokine. The negative correlation between FGF-21 and eGFR suggests renal elimination of the examined compound. (Pol J Endocrinol 2010; 61 (1): 50-54). PMID: 20205104 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338764 Fri, 01 Jan 2010 00:00:00 +0100 3338764 http://www.medworm.com/index.php?rid=3338763&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205105%26dopt%3DAbstract Conclusions: The present results indicate the necessity of careful analysis of administered drugs in hyperthyroid patients while qualifying them to (131)I therapy. The initial concentration of TSH has no effect on the efficacy of radioiodine therapy in cases where absorbed doses are regarded to be ablative. (Pol J Endocrinol 2010; 61 (1): 56-61). PMID: 20205105 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338763 Fri, 01 Jan 2010 00:00:00 +0100 3338763 http://www.medworm.com/index.php?rid=3338762&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205106%26dopt%3DAbstract Conclusions: Plurihormonality is a frequent phenomenon in both hormonally active and clinically non-functioning pituitary adenomas. It also seems to predict a higher risk of tumour recurrence. (Pol J Endocrinol 2010; 61 (1): 63-66). PMID: 20205106 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338762 Fri, 01 Jan 2010 00:00:00 +0100 3338762 http://www.medworm.com/index.php?rid=3338761&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205107%26dopt%3DAbstract Conclusions: Indications for surgery were recommended in 20% of patients with bilateral AI, most frequently for adenomas, nodular hyperplasia, and oncological pathologies, with a good prognosis in the non-malignant group. (Pol J Endocrinol 2010; 61 (1): 69-73). PMID: 20205107 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338761 Fri, 01 Jan 2010 00:00:00 +0100 3338761 http://www.medworm.com/index.php?rid=3338760&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205108%26dopt%3DAbstract Conclusions: The basal and reactive CGT is significantly decreased in lymphocytes of persons with T2DM before the introduction of therapy. Effective therapy with diet and sulfonylurea normalizes both types of CGT - basal and reactive. It is related to the near normalization of GLUT4 expression in the studied cells. This phenomenon may be used as a new marker for diabetes mellitus pharmacotherapy. (Pol J Endocrinol 2010; 61 (1): 75-81). PMID: 20205108 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338760 Fri, 01 Jan 2010 00:00:00 +0100 3338760 http://www.medworm.com/index.php?rid=3338759&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205109%26dopt%3DAbstract Conclusions: Fibrinogen plays an important role as a cardiovascular risk factor in acromegaly, irrespective of the cure of the disease. The role of CRP as a cardiovascular risk factor in patients with uncontrolled acromegaly should be better explained in future studies. (Pol J Endocrinol 2010; 61 (1): 83-88). PMID: 20205109 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338759 Fri, 01 Jan 2010 00:00:00 +0100 3338759 http://www.medworm.com/index.php?rid=3338758&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205110%26dopt%3DAbstract Conclusions: The temperamental characteristics and personal traits of patients with Addison's disease seem not to be useful in stressful events, and psychological support can be helpful in the effective therapy of these patients. (Pol J Endocrinol 2010; 61 (1): 90-92). PMID: 20205110 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338758 Fri, 01 Jan 2010 00:00:00 +0100 3338758 http://www.medworm.com/index.php?rid=3338757&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205111%26dopt%3DAbstract Conclusions: This study shows that LA is a safe, effective, and well-tolerated procedure. It may be recommended as a "gold standard" surgery in a case of benign functioning or non-functioning adrenal tumours with diameter less than 8 cm. (Pol J Endocrinol 2010; 61 (1): 94-101). PMID: 20205111 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338757 Fri, 01 Jan 2010 00:00:00 +0100 3338757 http://www.medworm.com/index.php?rid=3338756&cid=s_38197_15_f&fid=38197&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205112%26dopt%3DAbstract Conclusions: 1. Pituitary-adrenal axis hyperactivity is observed in patients with clinically active epilepsy, independently of the frequency of seizures and duration of the disease. 2. Changes in endogenous opioid system activity are related to the clinical activity of epilepsy - beta-endorphin concentrations are connected with frequency of seizures and duration of the disease and leu-enkephalin concentrations with duration of the disease. 3. Endogenous opioid peptides might take part in the neurochemical mechanism of human epilepsy. (Pol J Endocrinol 2010; 61 (1): 103-110). PMID: 20205112 [PubMed - in process] (Source: Endokrynologia Polska) Endokrynologia Polska journals http://www.medworm.com/rss/comments.php?id=3338756 Fri, 01 Jan 2010 00:00:00 +0100 3338756